VGAM
MCID: VNF001
MIFTS: 21

Vein of Galen Aneurysm (VGAM)

Categories: Cardiovascular diseases, Fetal diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Vein of Galen Aneurysm

MalaCards integrated aliases for Vein of Galen Aneurysm:

Name: Vein of Galen Aneurysm 53 72
Ectasia or Varix of the Vein of Galen 53
Vein of Galen Aneurysm Malformation 53
Galenic Arteriovenous Malformation 53
Galen Vein Aneurysm 53
Vgam 53

Classifications:



External Ids:

UMLS 72 C0431420

Summaries for Vein of Galen Aneurysm

NIH Rare Diseases : 53 Vein of Galen aneurysm is a rare form of arteriovenous malformation in which the embryonic precursor to the vein of Galen, a vein at the base of the brain, dilates causing too much blood to rush to the heart. This can lead to rapid heart failure. Other features may include increased head circumference resulting from hydrocephalus, unusually prominent veins on the face and scalp, developmental delay, persistent headache, and other neurological findings. Vein of Galen aneurysm is often recognized on an ultrasound late in pregnancy. In other cases, it is diagnosed after birth. Although the exact cause remains unknown, this condition appears to result from a defect in early fetal development. Treatment is aimed at decreasing the blood flow through the malformation while maximizing the blood supply to the brain. Minimally invasive surgical techniques are preferred, such as endovascular embolization.

MalaCards based summary : Vein of Galen Aneurysm, also known as ectasia or varix of the vein of galen, is related to capillary malformation-arteriovenous malformation 2 and capillary malformation-arteriovenous malformation 1. Affiliated tissues include heart, brain and pineal.

Related Diseases for Vein of Galen Aneurysm

Diseases related to Vein of Galen Aneurysm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Related Disease Score Top Affiliating Genes
1 capillary malformation-arteriovenous malformation 2 12.4
2 capillary malformation-arteriovenous malformation 1 11.8
3 aneurysm 10.9
4 arteriovenous malformation 10.7
5 hydrocephalus 10.7
6 congenital hydrocephalus 10.7
7 congestive heart failure 10.6
8 thrombosis 10.4
9 pulmonary hypertension 10.3
10 hydrocephalus, congenital, 1 10.3
11 hereditary hemorrhagic telangiectasia 10.3
12 telangiectasis 10.3
13 exophthalmos 10.3
14 thrombophilia due to thrombin defect 10.2
15 varicose veins 10.2
16 cyanosis, transient neonatal 10.2
17 heart disease 10.2
18 fetal edema 10.2
19 hydrops fetalis 10.2
20 lactic acidosis 10.1
21 patent ductus arteriosus 1 10.1
22 periventricular leukomalacia 10.1
23 heart septal defect 10.1
24 atrial heart septal defect 10.1
25 cerebral palsy 10.1
26 aortic coarctation 10.1
27 hemangioendothelioma 10.1
28 precocious puberty 10.1
29 cerebral malformation 10.1
30 dural sinus malformation 10.1
31 coarctation of aorta 10.0
32 neurofibromatosis, type iv, of riccardi 10.0
33 galactosemia 10.0
34 hydrops fetalis, nonimmune 10.0
35 ocular motor apraxia 10.0
36 branchiootic syndrome 1 10.0
37 porencephaly 10.0
38 spastic diplegia 10.0
39 placenta praevia 10.0
40 respiratory failure 10.0
41 visual epilepsy 10.0
42 aseptic meningitis 10.0
43 leiomyoma 10.0
44 patent foramen ovale 10.0
45 obstructive hydrocephalus 10.0
46 vascular disease 10.0
47 calcinosis 10.0
48 dysostosis 10.0
49 encephalomalacia 10.0
50 acute kidney failure 10.0

Graphical network of the top 20 diseases related to Vein of Galen Aneurysm:



Diseases related to Vein of Galen Aneurysm

Symptoms & Phenotypes for Vein of Galen Aneurysm

Drugs & Therapeutics for Vein of Galen Aneurysm

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Endovascular Management of Pediatric Intracranial Arteriovenous Shunts Not yet recruiting NCT03950258

Search NIH Clinical Center for Vein of Galen Aneurysm

Genetic Tests for Vein of Galen Aneurysm

Anatomical Context for Vein of Galen Aneurysm

MalaCards organs/tissues related to Vein of Galen Aneurysm:

41
Heart, Brain, Pineal, Fetal Brain

Publications for Vein of Galen Aneurysm

Articles related to Vein of Galen Aneurysm:

(show top 50) (show all 204)
# Title Authors PMID Year
1
Susceptibility weighted imaging in infants with staged embolization of vein of Galen aneurysmal malformations. 38
30423378 2019
2
Outcome of vein of Galen malformation presenting in the neonatal period. 38
31122925 2019
3
Endovascular Management of Vein of Galen Aneurysmal Malformations: A Retrospective Analysis over a 15-Year Period. 38
31308867 2019
4
Occlusion of a mural type vein of Galen malformation in a 10-month-old boy with three Woven EndoBridge (WEB 17) and two coils. 38
30988102 2019
5
Ethical Considerations in Multiple Pregnancy: Preterm Delivery in the Setting of Discordant Fetal Anomaly. 38
31023394 2019
6
Vein of Galen aneurismal malformations - clinical characteristics, treatment and presentation: Three cases report. 38
31024957 2019
7
Vein of Galen Aneurysmal Malformation: Advances in Management and Endovascular treatment. 38
29860355 2019
8
Outcome of Neonates with Vein of Galen Malformation Presenting with Severe Heart Failure: A Case Series. 38
29991070 2019
9
Pediatric encephalic ultrasonography: the essentials. 38
30552663 2018
10
Nationwide survey of pediatric intracranial arteriovenous shunts in Japan: Japanese Pediatric Arteriovenous Shunts Study (JPAS). 38
30052118 2018
11
Choroidal Type of Vein of Galen Aneurysmal Malformation in Adult Patient with Unusual Presentation of Orthostatic Headache. 38
29682048 2018
12
Adjuvant Coil Assisted Glue Embolization of Vein of Galen Aneurysmal Malformation in Pediatric Patients. 38
29535897 2018
13
Imaging Characteristics of Dural Arteriovenous Fistulas Involving the Vein of Galen: A Comprehensive Review. 38
29657906 2018
14
Repair of Sinus Venosus Defect and Anomalous Pulmonary Veins Associated With Vein of Galen Malformation. 38
29793383 2018
15
A Severe Case of Aneurysmal Malformation of the Vein of Galen, Cardiac Failure and Intrauterine Fetal Death. 38
30622760 2018
16
Diagnosis of Vein of Galen aneurysmal malformation using fetal MRI. 38
27689921 2017
17
Superselective transvenous embolization with Onyx and n-BCA for vein of Galen aneurysmal malformations with restricted transarterial access: safety, efficacy, and technical aspects. 38
28689342 2017
18
Vein of Galen aneurysmal malformation (VGAM) in the fetus: retrospective analysis of perinatal prognostic indicators in a two-center series of 49 cases. 38
27514305 2017
19
Antenatal diagnosis and prognostic factors of aneurysmal malformation of the vein of Galen: A case report and literature review. 38
28746188 2017
20
Periprocedural Management of Vein of Galen Aneurysmal Malformation Patients: An 11-Year Experience. 38
28928561 2017
21
The natural progression of VGAMs and the need for urgent medical attention: a systematic review and meta-analysis. 38
27091749 2017
22
Endovascular treatment of pediatric intracranial arteriovenous shunt. 38
27601322 2017
23
Pseudofeeders on fetal magnetic resonance imaging predict outcome in vein of Galen malformations. 38
28076893 2017
24
Endovascular treatment of vein of Galen aneurysmal malformation using rapid ventricular pacing: A case report. 38
27837112 2017
25
Vein of Galen aneurysmal malformation-clinical and angiographic spectrum with management perspective: an institutional experience. 38
26880722 2017
26
Galen Vein Aneurysm- Challenge for Treatment. 38
29318190 2017
27
Complex Alterations of Intracranial 4-Dimensional Hemodynamics in Vein of Galen Aneurysmal Malformations During Staged Endovascular Embolization. 38
29506111 2016
28
Endovascular management of a vein of Galen aneurysmal malformation in an infant with challenging femoral arterial access. 38
27058455 2016
29
Is jugular bulb stenosis in vein of Galen aneurysmal malformation associated with bony remodeling of the jugular foramina? 38
27035549 2016
30
Vein of Galen Aneurysmal Malformation in Monozygotic Twin. 38
27102351 2016
31
Sonographic Diagnosis of Fetal Adrenal Hemorrhage Complicating a Vein of Galen Aneurysmal Malformation. 38
26966627 2016
32
Antenatal diagnosis of aneurysmal malformation of the vein of Galen. 38
26643190 2015
33
Vein of Galen Arteriovenous Malformation in a Neonate. 38
26473426 2015
34
Intracranial pial fistulas in pediatric population. Clinical features and treatment modalities. 38
26054329 2015
35
Distinctive neck swelling in a patient with a vein of Galen arteriovenous malformation. 38
26191108 2015
36
Vein of galen aneurysmal malformation: prognostic markers depicted on fetal MRI. 38
25924177 2015
37
Neurocognitive improvements following endovascular repair of vein of Galen malformation in a child. 38
25479575 2015
38
Vein of Galen arteriovenous malformation mimicking coarctation of the aorta. 38
25368688 2014
39
Pure word deafness after resection of a Vein of Galen aneurysm and arteriovenous malformation: report of a case. 38
24956543 2014
40
The use of adenosine in the treatment of a high-flow vein of Galen malformation in an adult. 38
24491583 2014
41
Definitive treatment of vein of Galen aneurysmal malformation with stereotactic radiosurgery. 38
23870021 2014
42
ACVRL1 gene variant in a patient with vein of Galen aneurysmal malformation. 38
27625857 2013
43
Unexpected silent infarctions after embolization of cerebral arteriovenous malformations and fistulas. A diffusion-weighted magnetic resonance imaging study. 38
23693045 2013
44
Teaching neuroimages: vein of Galen aneurysm mimicking pineal mass in a young adult. 38
23713094 2013
45
Role of 3D power Doppler sonography in early prenatal diagnosis of Galen vein aneurysm. 38
24592100 2013
46
Estimated cardiac output and cardiovascular profile score in fetuses with high cardiac output lesions. 38
23001941 2013
47
The significance of 3D power Doppler in prenatal diagnosis and the evaluation of the anatomical structure of vein of Galen aneurysmatic malformation: case report. 38
23971266 2013
48
Hidden mortality of prenatally diagnosed vein of Galen aneurysmal malformation: retrospective study and review of the literature. 38
22605540 2012
49
Superior vena cava flow and management of neonates with vein of Galen malformation. 38
22933093 2012
50
Systolic heart murmur as first manifestation of high output heart failure due to the vein of galen malformation. 38
23021358 2012

Variations for Vein of Galen Aneurysm

Expression for Vein of Galen Aneurysm

Search GEO for disease gene expression data for Vein of Galen Aneurysm.

Pathways for Vein of Galen Aneurysm

GO Terms for Vein of Galen Aneurysm

Sources for Vein of Galen Aneurysm

3 CDC
7 CNVD
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10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
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31 HMDB
32 HPO
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34 ICD10 via Orphanet
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44 MeSH
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49 NCI
50 NCIt
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54 NINDS
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58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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