VGAM
MCID: VNF001
MIFTS: 27

Vein of Galen Aneurysm (VGAM)

Categories: Cardiovascular diseases, Fetal diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Vein of Galen Aneurysm

MalaCards integrated aliases for Vein of Galen Aneurysm:

Name: Vein of Galen Aneurysm 53 59 73
Vein of Galen Arteriovenous Malformations 59
Ectasia or Varix of the Vein of Galen 53
Vein of Galen Aneurysm Malformation 53
Galenic Arteriovenous Malformation 53
Galen Vein Aneurysm 53
Vgam 53

Characteristics:

Orphanet epidemiological data:

59
vein of galen aneurysm
Inheritance: Not applicable; Age of onset: Antenatal,Infancy,Neonatal;

Classifications:



External Ids:

Orphanet 59 ORPHA1053
MESH via Orphanet 45 C536535
ICD10 via Orphanet 34 Q28.2
UMLS via Orphanet 74 C0431420
SNOMED-CT via HPO 69 432119003 85659009
UMLS 73 C0431420

Summaries for Vein of Galen Aneurysm

NIH Rare Diseases : 53 Vein of Galen aneurysm is a rare form of arteriovenous malformation in which the embryonic precursor to the vein of Galen, a vein at the base of the brain, dilates causing too much blood to rush to the heart. This can lead to rapid heart failure. Other features may include increased head circumference resulting from hydrocephalus, unusually prominent veins on the face and scalp, developmental delay, persistent headache, and other neurological findings.  Vein of Galen aneurysm is often recognized on an ultrasound late in pregnancy. In other cases, it is diagnosed after birth. Although the exact cause remains unknown, this condition appears to result from a defect in early fetal development. Treatment is aimed at decreasing the blood flow through the malformation while maximizing the blood supply to the brain. Minimally invasive surgical techniques are preferred, such as endovascular embolization.

MalaCards based summary : Vein of Galen Aneurysm, also known as vein of galen arteriovenous malformations, is related to thrombosis and congestive heart failure. An important gene associated with Vein of Galen Aneurysm is EPHB4 (EPH Receptor B4). Affiliated tissues include heart, brain and pineal, and related phenotypes are abnormality of the cerebral vasculature and peripheral arteriovenous fistula

Related Diseases for Vein of Galen Aneurysm

Diseases related to Vein of Galen Aneurysm via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 17)
# Related Disease Score Top Affiliating Genes
1 thrombosis 10.3
2 congestive heart failure 10.3
3 hydrocephalus 10.2
4 aortic coarctation 10.1
5 coarctation of aorta 10.0
6 galactosemia 10.0
7 parkes weber syndrome 10.0
8 pulmonary hypertension 10.0
9 spastic diplegia 10.0
10 arteriovenous malformation 10.0
11 aseptic meningitis 10.0
12 exophthalmos 10.0
13 meningitis 10.0
14 hemoglobinemia 10.0
15 weber syndrome 10.0
16 tremor 10.0
17 headache 10.0

Graphical network of the top 20 diseases related to Vein of Galen Aneurysm:



Diseases related to Vein of Galen Aneurysm

Symptoms & Phenotypes for Vein of Galen Aneurysm

Human phenotypes related to Vein of Galen Aneurysm:

59 32
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 abnormality of the cerebral vasculature 59 32 hallmark (90%) Very frequent (99-80%) HP:0100659
2 peripheral arteriovenous fistula 59 32 frequent (33%) Frequent (79-30%) HP:0100784
3 aneurysm 59 Frequent (79-30%)
4 dilatation 32 frequent (33%) HP:0002617

Drugs & Therapeutics for Vein of Galen Aneurysm

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety of Apollo Micro Catheter in Pediatric Patients Completed NCT02085278 Not Applicable

Search NIH Clinical Center for Vein of Galen Aneurysm

Genetic Tests for Vein of Galen Aneurysm

Anatomical Context for Vein of Galen Aneurysm

MalaCards organs/tissues related to Vein of Galen Aneurysm:

41
Heart, Brain, Pineal

Publications for Vein of Galen Aneurysm

Articles related to Vein of Galen Aneurysm:

(show all 50)
# Title Authors Year
1
EP02.09: Early and uncommon prenatal diagnosis of vein of Galen aneurysm. ( 27645455 )
2016
2
Pure word deafness after resection of a Vein of Galen aneurysm and arteriovenous malformation: report of a case. ( 24956543 )
2014
3
Teaching neuroimages: vein of Galen aneurysm mimicking pineal mass in a young adult. ( 23713094 )
2013
4
Endovascular management of vein of galen aneurysm malformation: A series of two case reports. ( 21977085 )
2011
5
Confirmation of T1-bright vein of Galen aneurysm spontaneous thrombosis by subtraction magnetic resonance venography: a case report. ( 19626473 )
2009
6
Prenatal magnetic resonance imaging of vein of Galen aneurysm associated with congestive heart failure. ( 19067899 )
2008
7
Vein of Galen aneurysm in an adult: case report. ( 17057899 )
2006
8
Vein of Galen aneurysm complicated with pulmonary hypertension: report of one newborn case. ( 17016967 )
2006
9
Vein of Galen aneurysm: antenatal diagnosis: a case report. ( 16304858 )
2005
10
Vein of Galen aneurysm: anatomical study of an adult autopsy case. ( 15300864 )
2004
11
Vein of Galen aneurysm malformation (VGAM): closing the management loop. ( 15055912 )
2004
12
Spectrum of clinical presentations of vein of galen aneurysm. ( 15163883 )
2004
13
Hemodynamic analysis of an adult vein of Galen aneurysm malformation by use of 3D image-based computational fluid dynamics. ( 12812929 )
2003
14
Prenatal diagnosis of a vein of galen aneurysm. ( 12566774 )
2003
15
Surgical treatment of the thrombosed vein of galen aneurysm. ( 12376772 )
2002
16
Disseminated coagulopathy associated with transtorcular embolization of vein of Galen aneurysm in a neonate. ( 10685204 )
1999
17
Secondary vein of galen aneurysm : MR and MR angiographic demonstration. ( 29542655 )
1996
18
Special imaging casebook. Vein of Galen aneurysm. ( 8817440 )
1996
19
Prenatal diagnosis and prognosis of a vein of Galen aneurysm assessed by pulsed and color Doppler sonography. ( 8705421 )
1996
20
Prenatal sonographic diagnosis of a vein of Galen aneurysm: relevance of associated malformations for timing and mode of delivery. ( 8590193 )
1995
21
A vein of Galen aneurysm with an abnormal drain system: MRI findings. ( 7491195 )
1995
22
Vein of Galen aneurysm: MRI with a fast gradient refocusing pulse sequence. ( 8332410 )
1993
23
Color Doppler sonography as a primary diagnostic tool in the diagnosis of vein of Galen aneurysm in a critically ill neonate. ( 7904055 )
1993
24
Prenatal magnetic resonance imaging detection of a vein of Galen aneurysm. ( 8306350 )
1993
25
The increase in plethysmographic amplitude due to the clipping of the vein of Galen aneurysm. ( 8346849 )
1993
26
Pathologic findings in a patient with a vein of Galen aneurysm treated by staged endovascular embolization. ( 8481943 )
1993
27
Early diagnosis of a vein of Galen aneurysm: report of a case. ( 1363216 )
1992
28
Vein of Galen aneurysm presenting in middle age. ( 1449674 )
1992
29
Case report: in utero diagnosis of a vein of Galen aneurysm using colour flow Doppler. ( 1959310 )
1991
30
Vein of Galen aneurysm and hydrocephalus. ( 1794114 )
1991
31
Vein of Galen aneurysm. ( 2228099 )
1990
32
Vein of Galen aneurysm presenting with recurrent aseptic meningitis and subsequent spontaneous thrombosis. ( 2330533 )
1990
33
Successful surgical and anesthetic management of vein of Galen aneurysm in a neonate in congestive heart failure. ( 3380281 )
1988
34
Anesthetic management of hemodynamic changes during vein of Galen aneurysm clipping. ( 3195776 )
1988
35
Vein of Galen aneurysm associated with dural AVM and straight sinus thrombosis. Case report. ( 3339446 )
1988
36
Hemoglobinemia and renal failure from an intracerebral hematoma simulating a vein of Galen aneurysm. ( 3614590 )
1987
37
Spontaneous thrombosis of a vein of Galen aneurysm. ( 3120540 )
1987
38
Vascular steal associated with vein of Galen aneurysm. ( 6544380 )
1984
39
In utero diagnosis of a vein of Galen aneurysm by ultrasound. ( 6399929 )
1984
40
Vein of Galen aneurysm. ( 6619087 )
1983
41
Diagnosis of a vein of Galen aneurysm by ultrasound. ( 6811625 )
1982
42
Thrombosed vein of Galen aneurysm. ( 7070623 )
1982
43
Unusual manifestation of vein of Galen aneurysm. ( 6810676 )
1982
44
Turner's syndrome and vein of Galen aneurysm--a previously unreported association. ( 7349577 )
1981
45
Vein of Galen aneurysm - diagnosis by real-time ultrasound. ( 7328101 )
1981
46
Hydrocephalus associated with arterio-venous malformation - the vein of Galen aneurysm. ( 551620 )
1979
47
Vein of Galen aneurysm: successful excision of a completely thrombosed aneurysm in an infant. ( 4810450 )
1974
48
Vein of Galen aneurysm. ( 4722476 )
1973
49
Pneumoencephalographic findings in a case of vein of Galen aneurysm. ( 5117054 )
1971
50
Excision of thrombosed vein of Galen aneurysm in an infant. Case report. ( 5304310 )
1968

Variations for Vein of Galen Aneurysm

Expression for Vein of Galen Aneurysm

Search GEO for disease gene expression data for Vein of Galen Aneurysm.

Pathways for Vein of Galen Aneurysm

GO Terms for Vein of Galen Aneurysm

Sources for Vein of Galen Aneurysm

3 CDC
7 CNVD
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10 dbSNP
11 DGIdb
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32 HPO
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34 ICD10 via Orphanet
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49 NCI
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51 NDF-RT
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58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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