MCID: VNZ002
MIFTS: 47

Venezuelan Equine Encephalitis

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Venezuelan Equine Encephalitis

MalaCards integrated aliases for Venezuelan Equine Encephalitis:

Name: Venezuelan Equine Encephalitis 12 53 15
Encephalomyelitis, Venezuelan Equine 44
Venezuelan Equine Encephalomyelitis 73
Encephalitis Venezuelan Equine 55
Venezuelan Equine Fever 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9584
ICD10 33 A92.2
ICD9CM 35 066.2
MeSH 44 D004685
NCIt 50 C35121
UMLS 73 C0014078

Summaries for Venezuelan Equine Encephalitis

Disease Ontology : 12 A viral infectious disease that results in inflammation located in brain of horses and humans, has material basis in Venezuelan equine encephalitis virus, which is transmitted by Culex mosquitoes. The infection has symptom fever, has symptom chills, has symptom malaise, has symptom severe headache, has symptom photophobia, and has symptom myalgia in the legs and lumbosacral region.

MalaCards based summary : Venezuelan Equine Encephalitis, also known as encephalomyelitis, venezuelan equine, is related to japanese encephalitis and encephalitis, and has symptoms including fever, chills and malaise. An important gene associated with Venezuelan Equine Encephalitis is RPSA (Ribosomal Protein SA), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Vaccines and Mitogens have been mentioned in the context of this disorder. Affiliated tissues include brain of horses, brain and t cells, and related phenotypes are hematopoietic system and neoplasm

Related Diseases for Venezuelan Equine Encephalitis

Graphical network of the top 20 diseases related to Venezuelan Equine Encephalitis:



Diseases related to Venezuelan Equine Encephalitis

Symptoms & Phenotypes for Venezuelan Equine Encephalitis

Symptoms:

12
  • fever
  • chills
  • malaise
  • severe headache
  • photophobia
  • myalgia in the legs

MGI Mouse Phenotypes related to Venezuelan Equine Encephalitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.43 IFNB1 IRF1 IRF7 LGALS3 RPSA STAT1
2 neoplasm MP:0002006 9.02 IFNB1 IRF1 LGALS3 SAT1 STAT1

Drugs & Therapeutics for Venezuelan Equine Encephalitis

Drugs for Venezuelan Equine Encephalitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 2,Phase 1
2 Mitogens Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety and Immunogenicity of Venezuelan Equine Encephalomyelitis Vaccine (VEE C-84) as a Booster to VEE TC-83 Active, not recruiting NCT00582088 Phase 2
2 Safety and Immunogenicity Study of the Venezuelan Equine Encephalomyelitis Vaccine Enrolling by invitation NCT00582504 Phase 2
3 Safety and Immunogenicity Study of Venezuelan Equine Encephalomyelitis (VEE) Vaccine as Booster Vaccine in Adults Not yet recruiting NCT03531242 Phase 2
4 Safety and Immunogenicity of Venezuelan Equine Encephalomyelitis Vaccine in Healthy Adults Not yet recruiting NCT03051386 Phase 2
5 Study of a DNA-based Venezuelan Equine Encephalitis Virus DNA Vaccine Administered by Electroporation in Healthy Volunteers Completed NCT01984983 Phase 1
6 A Phase I Study To Evaluate The Antitumor Activity And Safety Of AVX901 Completed NCT01526473 Phase 1
7 Safety, Tolerability and Immunogenicity of the Venezuelan Equine Encephalitis (VEE) Attenuated Live-Virus Vaccine Withdrawn NCT00109304 Phase 1

Search NIH Clinical Center for Venezuelan Equine Encephalitis

Cochrane evidence based reviews: encephalomyelitis, venezuelan equine

Genetic Tests for Venezuelan Equine Encephalitis

Anatomical Context for Venezuelan Equine Encephalitis

The Foundational Model of Anatomy Ontology organs/tissues related to Venezuelan Equine Encephalitis:

19
Brain Of Horses

MalaCards organs/tissues related to Venezuelan Equine Encephalitis:

41
Brain, T Cells, Myeloid, Testes, Olfactory Bulb, Pancreas, Spleen

Publications for Venezuelan Equine Encephalitis

Articles related to Venezuelan Equine Encephalitis:

(show top 50) (show all 444)
# Title Authors Year
1
Development of a Broadly Accessible Venezuelan Equine Encephalitis Virus Replicon Particle Vaccine Platform. ( 29540599 )
2018
2
Protein Phosphatase 1I+ Interacts with Venezuelan Equine Encephalitis Virus Capsid Protein and Regulates Viral Replication through Modulation of Capsid Phosphorylation. ( 29769351 )
2018
3
Low-fidelity Venezuelan equine encephalitis virus polymerase mutants to improve live-attenuated vaccine safety and efficacy. ( 29593882 )
2018
4
Evaluation of the inactivation of Venezuelan equine encephalitis virus by several common methods. ( 29407211 )
2018
5
Identification of novel antivirals inhibiting recognition of Venezuelan equine encephalitis virus capsid protein by the Importin I+/I^1 heterodimer through high-throughput screening. ( 29337164 )
2018
6
Potential Sympatric Vectors and Mammalian Hosts of Venezuelan Equine Encephalitis Virus in Southern Mexico. ( 28384059 )
2017
7
An immunoinformatics-derived DNA vaccine encoding human class II T cell epitopes of Ebola virus, Sudan virus, and Venezuelan equine encephalitis virus is immunogenic in HLA transgenic mice. ( 28575582 )
2017
8
Live, Attenuated Venezuelan Equine Encephalitis Virus Vaccine (TC83) Causes Persistent Brain Infection in Mice with Non-functional I+I^ T-Cells. ( 28184218 )
2017
9
Antibody Preparations from Human Transchromosomic Cows Exhibit Prophylactic and Therapeutic Efficacy against Venezuelan Equine Encephalitis Virus. ( 28468884 )
2017
10
Ablation of Programmed -1 Ribosomal Frameshifting in Venezuelan Equine Encephalitis Virus Results in Attenuated Neuropathogenicity. ( 27852852 )
2017
11
Mutation of Asn-475 in the Venezuelan Equine Encephalitis Virus nsP2 Cysteine Protease Leads to a Self-Inhibited State. ( 29064679 )
2017
12
Novel inhibitors targeting Venezuelan equine encephalitis virus capsid protein identified using In Silico Structure-Based-Drug-Design. ( 29255256 )
2017
13
Altered mitochondrial dynamics as a consequence of Venezuelan Equine Encephalitis Virus infection. ( 28075229 )
2017
14
Differential host gene responses from infection with neurovirulent and partially-neurovirulent strains of Venezuelan equine encephalitis virus. ( 28446152 )
2017
15
Evolution and spread of Venezuelan equine encephalitis complex alphavirus in the Americas. ( 28771475 )
2017
16
Venezuelan Equine Encephalitis Virus Capsid-The Clever Caper. ( 28961161 )
2017
17
Venezuelan equine encephalitis: How likely are we to see the next epidemic? ( 28242351 )
2017
18
Development of high-throughput and high sensitivity capillary gel electrophoresis platform method for Western, Eastern, and Venezuelan equine encephalitis (WEVEE) virus like particles (VLPs) purity determination and characterization. ( 28842921 )
2017
19
Human transcriptome response to immunization with live-attenuated Venezuelan equine encephalitis virus vaccine (TC-83): Analysis of whole blood. ( 27870591 )
2016
20
Epidemiology of Emergent Madariaga Encephalitis in a Region with Endemic Venezuelan Equine Encephalitis: Initial Host Studies and Human Cross-Sectional Study in Darien, Panama. ( 27101567 )
2016
21
Effect of Holding Conditions on the Detection of Chikungunya and Venezuelan Equine Encephalitis Viruses in Mosquito Pools. ( 27105216 )
2016
22
Kinetic, Mutational, and Structural Studies of the Venezuelan Equine Encephalitis Virus Nonstructural Protein 2 Cysteine Protease. ( 27030368 )
2016
23
Bibliometric assessment of global research on Venezuelan Equine Encephalitis: A latent threat for the Americas. ( 27640115 )
2016
24
1,5-Iodonaphthyl azide-inactivated V3526 protects against aerosol challenge with virulent venezuelan equine encephalitis virus. ( 27129427 )
2016
25
Host translation shutoff mediated by non-structural protein 2 is a critical factor in the antiviral state resistance of Venezuelan equine encephalitis virus. ( 27318152 )
2016
26
Venezuelan equine encephalitis virus non-structural protein 3 (nsP3) interacts with RNA helicases DDX1 and DDX3 in infected cells. ( 27105836 )
2016
27
A Phase 1 clinical trial of a DNA vaccine for Venezuelan equine encephalitis delivered by intramuscular or intradermal electroporation. ( 27206386 )
2016
28
The SD1 Subdomain of Venezuelan Equine Encephalitis Virus Capsid Protein Plays a Critical Role in Nucleocapsid and Particle Assembly. ( 26656680 )
2016
29
A novel cell-based assay to measure activity of Venezuelan equine encephalitis virus nsP2 protease. ( 27261892 )
2016
30
Engineered Mesenchymal Cells Improve Passive Immune Protection Against Lethal Venezuelan Equine Encephalitis Virus Exposure. ( 27334491 )
2016
31
Venezuelan Equine Encephalitis Virus Induces Apoptosis through the Unfolded Protein Response Activation of EGR1. ( 26792742 )
2016
32
Characterization of Genetic Variability of Venezuelan Equine Encephalitis Viruses. ( 27054586 )
2016
33
A Quantitative Real-Time RT-PCR Assay for the Detection of Venezuelan equine encephalitis virus Utilizing a Universal Alphavirus Control RNA. ( 28042576 )
2016
34
Mayaro, Oropouche and Venezuelan Equine Encephalitis viruses: Following in the footsteps of Zika? ( 27826073 )
2016
35
Genetic diversity of Venezuelan alphaviruses and circulation of a Venezuelan equine encephalitis virus subtype IAB strain during an interepizootic period. ( 25940191 )
2015
36
Demographics of natural oral infection of mosquitos by venezuelan equine encephalitis virus. ( 25589654 )
2015
37
IRES-Containing VEEV Vaccine Protects Cynomolgus Macaques from IE Venezuelan Equine Encephalitis Virus Aerosol Challenge. ( 26020513 )
2015
38
Complete coding sequences of eastern equine encephalitis virus and venezuelan equine encephalitis virus strains isolated from human cases. ( 25908124 )
2015
39
The ubiquitin proteasome system plays a role in venezuelan equine encephalitis virus infection. ( 25927990 )
2015
40
Melatonin decreases brain apoptosis, oxidative stress, and CD200 expression and increased survival rate in mice infected by Venezuelan equine encephalitis virus. ( 27503577 )
2015
41
Melatonin, minocycline and ascorbic acid reduce oxidative stress and viral titers and increase survival rate in experimental Venezuelan equine encephalitis. ( 26168898 )
2015
42
Correction: IRES-Containing VEEV Vaccine Protects Cynomolgus Macaques from IE Venezuelan Equine Encephalitis Virus Aerosol Challenge. ( 26107877 )
2015
43
mRNA Capping by Venezuelan Equine Encephalitis Virus nsP1: Functional Characterization and Implications for Antiviral Research. ( 26041283 )
2015
44
Role of angiotensin II in experimental Venezuelan equine encephalitis in rats. ( 26156105 )
2015
45
Structural and biophysical analysis of sequence insertions in the Venezuelan Equine Encephalitis Virus macro domain. ( 25725151 )
2015
46
Development of (E)-2-((1,4-Dimethylpiperazin-2-ylidene)amino)-5-nitro-N-phenylbenzamide, ML336: Novel 2-Amidinophenylbenzamides as Potent Inhibitors of Venezuelan Equine Encephalitis Virus. ( 25244572 )
2014
47
Discovery of a novel compound with anti-venezuelan equine encephalitis virus activity that targets the nonstructural protein 2. ( 24967809 )
2014
48
Venezuelan equine encephalitis virus variants lacking transcription inhibitory functions demonstrate highly attenuated phenotype. ( 25320296 )
2014
49
Small molecule inhibitors of Ago2 decrease Venezuelan equine encephalitis virus replication. ( 25448087 )
2014
50
NMR study of non-structural proteins-part II: (1)H, (13)C, (15)N backbone and side-chain resonance assignment of macro domain from Venezuelan equine encephalitis virus (VEEV). ( 25291978 )
2014

Variations for Venezuelan Equine Encephalitis

Expression for Venezuelan Equine Encephalitis

Search GEO for disease gene expression data for Venezuelan Equine Encephalitis.

Pathways for Venezuelan Equine Encephalitis

Pathways related to Venezuelan Equine Encephalitis according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.62 IFNB1 IL32 IRF1 IRF7 LGALS3 STAT1
2
Show member pathways
12.96 IFNB1 IL32 IRF1 IRF7 STAT1
3
Show member pathways
12.41 IFNB1 IRF1 IRF7
4
Show member pathways
12.19 IFNB1 IRF7 STAT1
5 12.14 IRF1 IRF7 LGALS3 STAT1
6
Show member pathways
12.05 IFNB1 IRF1 IRF7 STAT1
7
Show member pathways
12.05 IFNB1 IRF1 IRF7 STAT1
8
Show member pathways
11.83 IFNB1 IRF1 STAT1
9 11.78 IFNB1 IRF1 IRF7
10 11.57 IFNB1 IRF1 IRF7
11
Show member pathways
11.49 IRF1 STAT1
12 11.45 IRF1 STAT1
13 11.41 IFNB1 IRF7
14 11.33 LGALS3 STAT1
15 11.04 IFNB1 IRF1 IRF7 STAT1
16
Show member pathways
10.84 IRF7 STAT1
17 10.7 IFNB1 IRF1 STAT1

GO Terms for Venezuelan Equine Encephalitis

Biological processes related to Venezuelan Equine Encephalitis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.81 IFNB1 IRF1 IRF7 STAT1
2 viral process GO:0016032 9.7 IRF7 RPSA STAT1
3 cytokine-mediated signaling pathway GO:0019221 9.65 IFNB1 IL32 STAT1
4 defense response to virus GO:0051607 9.56 IFNB1 IRF1 IRF7 STAT1
5 interferon-gamma-mediated signaling pathway GO:0060333 9.5 IRF1 IRF7 STAT1
6 positive regulation of type I interferon production GO:0032481 9.49 IRF1 IRF7
7 regulation of type I interferon-mediated signaling pathway GO:0060338 9.46 IFNB1 STAT1
8 positive regulation of interferon-beta production GO:0032728 9.43 IRF1 IRF7
9 positive regulation of interferon-alpha production GO:0032727 9.4 IRF7 STAT1
10 regulation of adaptive immune response GO:0002819 9.37 IRF1 IRF7
11 regulation of MyD88-dependent toll-like receptor signaling pathway GO:0034124 9.16 IRF1 IRF7
12 cellular response to interferon-beta GO:0035458 9.13 IFNB1 IRF1 STAT1
13 type I interferon signaling pathway GO:0060337 8.92 IFNB1 IRF1 IRF7 STAT1

Molecular functions related to Venezuelan Equine Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 9.16 IRF7 STAT1
2 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000982 8.96 IRF7 STAT1
3 laminin binding GO:0043236 8.62 LGALS3 RPSA

Sources for Venezuelan Equine Encephalitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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