MCID: VNZ002
MIFTS: 44

Venezuelan Equine Encephalitis

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Venezuelan Equine Encephalitis

MalaCards integrated aliases for Venezuelan Equine Encephalitis:

Name: Venezuelan Equine Encephalitis 12 54 15 17
Encephalomyelitis, Venezuelan Equine 45
Venezuelan Equine Encephalomyelitis 74
Encephalitis Venezuelan Equine 56
Venezuelan Equine Fever 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9584
ICD9CM 36 066.2
MeSH 45 D004685
NCIt 51 C35121
SNOMED-CT 69 89990001
ICD10 34 A92.2
UMLS 74 C0014078

Summaries for Venezuelan Equine Encephalitis

Disease Ontology : 12 A viral infectious disease that results in inflammation located in brain of horses and humans, has material basis in Venezuelan equine encephalitis virus, which is transmitted by Culex mosquitoes. The infection has symptom fever, has symptom chills, has symptom malaise, has symptom severe headache, has symptom photophobia, and has symptom myalgia in the legs and lumbosacral region.

MalaCards based summary : Venezuelan Equine Encephalitis, also known as encephalomyelitis, venezuelan equine, is related to influenza and encephalitis, and has symptoms including photophobia, fever and chills. An important gene associated with Venezuelan Equine Encephalitis is RPSA (Ribosomal Protein SA), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Interferon gamma signaling. The drugs Immunologic Factors and Vaccines have been mentioned in the context of this disorder. Affiliated tissues include brain, t cells and kidney.

Related Diseases for Venezuelan Equine Encephalitis

Diseases related to Venezuelan Equine Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 25)
# Related Disease Score Top Affiliating Genes
1 influenza 29.6 IFNB1 IRF7 XPO1
2 encephalitis 11.4
3 vaccinia 10.4
4 chikungunya 10.3
5 tick-borne encephalitis 10.3
6 eastern equine encephalitis 10.3
7 st. louis encephalitis 10.2
8 anthrax disease 10.2
9 human immunodeficiency virus type 1 10.1
10 mumps 10.1
11 western equine encephalitis 10.1
12 japanese encephalitis 10.1
13 lyme disease 10.1
14 rift valley fever 10.1
15 coccidioidomycosis 10.1
16 mouth disease 10.1
17 ebola hemorrhagic fever 10.1
18 herpes simplex 10.1
19 cowpox 10.1
20 stomatitis 10.1
21 yellow fever 10.1
22 respiratory syncytial virus infectious disease 9.9 IFNB1 IRF1
23 breast abscess 9.9 IFNB1 XPO1
24 noonan syndrome 3 9.8 DDX3X IFNB1
25 viral infectious disease 9.6 IFNB1 IRF1 IRF7

Graphical network of the top 20 diseases related to Venezuelan Equine Encephalitis:



Diseases related to Venezuelan Equine Encephalitis

Symptoms & Phenotypes for Venezuelan Equine Encephalitis

Symptoms:

12
  • photophobia
  • fever
  • chills
  • malaise
  • severe headache
  • myalgia in the legs

Drugs & Therapeutics for Venezuelan Equine Encephalitis

Drugs for Venezuelan Equine Encephalitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunologic Factors Phase 2,Phase 1
2 Vaccines Phase 2,Phase 1
3
Aluminum hydroxide Approved, Investigational Phase 1 21645-51-2
4
Aluminum sulfate Approved Phase 1 10043-01-3
5 Mitogens Phase 1
6 Gastrointestinal Agents Phase 1
7 Antacids Phase 1
8 Anti-Ulcer Agents Phase 1
9 Adjuvants, Immunologic Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety and Immunogenicity of Venezuelan Equine Encephalomyelitis Vaccine in Healthy Adults Recruiting NCT03051386 Phase 2
2 Safety and Immunogenicity of Venezuelan Equine Encephalomyelitis Vaccine (VEE C-84) as a Booster to VEE TC-83 Active, not recruiting NCT00582088 Phase 2
3 Safety and Immunogenicity Study of the Venezuelan Equine Encephalomyelitis Vaccine Enrolling by invitation NCT00582504 Phase 2
4 Safety and Immunogenicity Study of Venezuelan Equine Encephalomyelitis (VEE) Vaccine as Booster Vaccine in Adults Not yet recruiting NCT03531242 Phase 2
5 Study of a DNA-based Venezuelan Equine Encephalitis Virus DNA Vaccine Administered by Electroporation in Healthy Volunteers Completed NCT01984983 Phase 1
6 A Phase I Study To Evaluate The Antitumor Activity And Safety Of AVX901 Completed NCT01526473 Phase 1
7 Venezuelan Equine Encephalitis Monovalent Virus-Like Particle Vaccine Recruiting NCT03776994 Phase 1
8 VRC 313: A Trivalent Virus-like Particle (VLP) Encephalitis Vaccine (WEVEE) in Healthy Adults Recruiting NCT03879603 Phase 1
9 Safety, Tolerability and Immunogenicity of the Venezuelan Equine Encephalitis (VEE) Attenuated Live-Virus Vaccine Withdrawn NCT00109304 Phase 1

Search NIH Clinical Center for Venezuelan Equine Encephalitis

Cochrane evidence based reviews: encephalomyelitis, venezuelan equine

Genetic Tests for Venezuelan Equine Encephalitis

Anatomical Context for Venezuelan Equine Encephalitis

MalaCards organs/tissues related to Venezuelan Equine Encephalitis:

42
Brain, T Cells, Kidney, Testes, Spleen, Pancreas, Whole Blood

The Foundational Model of Anatomy Ontology organs/tissues related to Venezuelan Equine Encephalitis:

20
Brain Of Horses

Publications for Venezuelan Equine Encephalitis

Articles related to Venezuelan Equine Encephalitis:

(show top 50) (show all 458)
# Title Authors Year
1
Novel DNA-launched Venezuelan equine encephalitis virus vaccine with rearranged genome. ( 31072736 )
2019
2
Human cathelicidin peptide LL-37 as a therapeutic antiviral targeting Venezuelan equine encephalitis virus infections. ( 30738837 )
2019
3
Proteolytic cleavage of host proteins by the Group IV viral proteases of Venezuelan equine encephalitis virus and Zika virus. ( 30742841 )
2019
4
Self-Amplifying RNA Vaccines for Venezuelan Equine Encephalitis Virus Induce Robust Protective Immunogenicity in Mice. ( 30770173 )
2019
5
Current Understanding of the Molecular Basis of Venezuelan Equine Encephalitis Virus Pathogenesis and Vaccine Development. ( 30781656 )
2019
6
Novel RU486 (mifepristone) analogues with increased activity against Venezuelan Equine Encephalitis Virus but reduced progesterone receptor antagonistic activity. ( 30796232 )
2019
7
Approved drugs screening against the nsP1 capping enzyme of Venezuelan equine encephalitis virus using an immuno-based assay. ( 30639438 )
2019
8
Eco-epidemiology of the Venezuelan equine encephalitis virus in bats of Córdoba and Sucre, Colombia. ( 30578748 )
2018
9
Venezuelan Equine Encephalitis Virus Capsid Implicated in Infection-Induced Cell Cycle Delay in vitro. ( 30631316 )
2018
10
Author Correction: Novel inhibitors targeting Venezuelan equine encephalitis virus capsid protein identified using In Silico Structure-Based-Drug-Design. ( 30177745 )
2018
11
The genetic adjuvant IL-12 enhances the protective efficacy of a DNA vaccine for Venezuelan equine encephalitis virus delivered by intramuscular injection in mice. ( 30268913 )
2018
12
Comparison of Aerosol- and Percutaneous-acquired Venezuelan Equine Encephalitis in Humans and Nonhuman Primates for Suitability in Predicting Clinical Efficacy under the Animal Rule. ( 30282570 )
2018
13
Repurposed FDA-Approved drug sorafenib reduces replication of Venezuelan equine encephalitis virus and other alphaviruses. ( 29981794 )
2018
14
Protein Phosphatase 1α Interacts with Venezuelan Equine Encephalitis Virus Capsid Protein and Regulates Viral Replication through Modulation of Capsid Phosphorylation. ( 29769351 )
2018
15
Low-fidelity Venezuelan equine encephalitis virus polymerase mutants to improve live-attenuated vaccine safety and efficacy. ( 29593882 )
2018
16
Evaluation of the inactivation of Venezuelan equine encephalitis virus by several common methods. ( 29407211 )
2018
17
Development of a Broadly Accessible Venezuelan Equine Encephalitis Virus Replicon Particle Vaccine Platform. ( 29540599 )
2018
18
Identification of novel antivirals inhibiting recognition of Venezuelan equine encephalitis virus capsid protein by the Importin α/β1 heterodimer through high-throughput screening. ( 29337164 )
2018
19
Novel inhibitors targeting Venezuelan equine encephalitis virus capsid protein identified using In Silico Structure-Based-Drug-Design. ( 29255256 )
2017
20
Mutation of Asn-475 in the Venezuelan Equine Encephalitis Virus nsP2 Cysteine Protease Leads to a Self-Inhibited State. ( 29064679 )
2017
21
Development of high-throughput and high sensitivity capillary gel electrophoresis platform method for Western, Eastern, and Venezuelan equine encephalitis (WEVEE) virus like particles (VLPs) purity determination and characterization. ( 28842921 )
2017
22
Venezuelan Equine Encephalitis Virus Capsid-The Clever Caper. ( 28961161 )
2017
23
Evolution and spread of Venezuelan equine encephalitis complex alphavirus in the Americas. ( 28771475 )
2017
24
Differential host gene responses from infection with neurovirulent and partially-neurovirulent strains of Venezuelan equine encephalitis virus. ( 28446152 )
2017
25
Antibody Preparations from Human Transchromosomic Cows Exhibit Prophylactic and Therapeutic Efficacy against Venezuelan Equine Encephalitis Virus. ( 28468884 )
2017
26
An immunoinformatics-derived DNA vaccine encoding human class II T cell epitopes of Ebola virus, Sudan virus, and Venezuelan equine encephalitis virus is immunogenic in HLA transgenic mice. ( 28575582 )
2017
27
Venezuelan equine encephalitis: How likely are we to see the next epidemic? ( 28242351 )
2017
28
Potential Sympatric Vectors and Mammalian Hosts of Venezuelan Equine Encephalitis Virus in Southern Mexico. ( 28384059 )
2017
29
Altered mitochondrial dynamics as a consequence of Venezuelan Equine encephalitis virus infection. ( 28075229 )
2017
30
Live, Attenuated Venezuelan Equine Encephalitis Virus Vaccine (TC83) Causes Persistent Brain Infection in Mice with Non-functional αβ T-Cells. ( 28184218 )
2017
31
Mayaro, Oropouche and Venezuelan Equine Encephalitis viruses: Following in the footsteps of Zika? ( 27826073 )
2017
32
Ablation of Programmed -1 Ribosomal Frameshifting in Venezuelan Equine Encephalitis Virus Results in Attenuated Neuropathogenicity. ( 27852852 )
2017
33
Human transcriptome response to immunization with live-attenuated Venezuelan equine encephalitis virus vaccine (TC-83): Analysis of whole blood. ( 27870591 )
2017
34
Bibliometric assessment of global research on Venezuelan Equine Encephalitis: A latent threat for the Americas. ( 27640115 )
2017
35
Effect of Holding Conditions on the Detection of Chikungunya and Venezuelan Equine Encephalitis Viruses in Mosquito Pools. ( 27105216 )
2016
36
A Quantitative Real-Time RT-PCR Assay for the Detection of Venezuelan equine encephalitis virus Utilizing a Universal Alphavirus Control RNA. ( 28042576 )
2016
37
A Phase 1 clinical trial of a DNA vaccine for Venezuelan equine encephalitis delivered by intramuscular or intradermal electroporation. ( 27206386 )
2016
38
A novel cell-based assay to measure activity of Venezuelan equine encephalitis virus nsP2 protease. ( 27261892 )
2016
39
Host translation shutoff mediated by non-structural protein 2 is a critical factor in the antiviral state resistance of Venezuelan equine encephalitis virus. ( 27318152 )
2016
40
Engineered Mesenchymal Cells Improve Passive Immune Protection Against Lethal Venezuelan Equine Encephalitis Virus Exposure. ( 27334491 )
2016
41
Kinetic, Mutational, and Structural Studies of the Venezuelan Equine Encephalitis Virus Nonstructural Protein 2 Cysteine Protease. ( 27030368 )
2016
42
Characterization of Genetic Variability of Venezuelan Equine Encephalitis Viruses. ( 27054586 )
2016
43
Epidemiology of Emergent Madariaga Encephalitis in a Region with Endemic Venezuelan Equine Encephalitis: Initial Host Studies and Human Cross-Sectional Study in Darien, Panama. ( 27101567 )
2016
44
Venezuelan equine encephalitis virus non-structural protein 3 (nsP3) interacts with RNA helicases DDX1 and DDX3 in infected cells. ( 27105836 )
2016
45
1,5-Iodonaphthyl azide-inactivated V3526 protects against aerosol challenge with virulent venezuelan equine encephalitis virus. ( 27129427 )
2016
46
Venezuelan Equine Encephalitis Virus Induces Apoptosis through the Unfolded Protein Response Activation of EGR1. ( 26792742 )
2016
47
The SD1 Subdomain of Venezuelan Equine Encephalitis Virus Capsid Protein Plays a Critical Role in Nucleocapsid and Particle Assembly. ( 26656680 )
2016
48
Complete coding sequences of eastern equine encephalitis virus and venezuelan equine encephalitis virus strains isolated from human cases. ( 25908124 )
2015
49
Melatonin decreases brain apoptosis, oxidative stress, and CD200 expression and increased survival rate in mice infected by Venezuelan equine encephalitis virus. ( 27503577 )
2015
50
mRNA Capping by Venezuelan Equine Encephalitis Virus nsP1: Functional Characterization and Implications for Antiviral Research. ( 26041283 )
2015

Variations for Venezuelan Equine Encephalitis

Expression for Venezuelan Equine Encephalitis

Search GEO for disease gene expression data for Venezuelan Equine Encephalitis.

Pathways for Venezuelan Equine Encephalitis

GO Terms for Venezuelan Equine Encephalitis

Cellular components related to Venezuelan Equine Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.17 DDX3X IL32 IRF1 IRF7 RPSA SAT1
2 cytosolic small ribosomal subunit GO:0022627 8.96 DDX3X RPSA

Biological processes related to Venezuelan Equine Encephalitis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.8 DDX3X IFNB1 IRF1 IRF7
2 viral process GO:0016032 9.67 DDX3X IRF7 RPSA XPO1
3 defense response to virus GO:0051607 9.61 IFNB1 IRF1 IRF7
4 ribosome biogenesis GO:0042254 9.51 DDX3X XPO1
5 response to virus GO:0009615 9.5 DDX3X IFNB1 IRF7
6 interferon-gamma-mediated signaling pathway GO:0060333 9.48 IRF1 IRF7
7 positive regulation of type I interferon production GO:0032481 9.46 IRF1 IRF7
8 cellular response to interferon-beta GO:0035458 9.4 IFNB1 IRF1
9 type I interferon signaling pathway GO:0060337 9.33 IFNB1 IRF1 IRF7
10 regulation of adaptive immune response GO:0002819 9.26 IRF1 IRF7
11 regulation of MyD88-dependent toll-like receptor signaling pathway GO:0034124 8.96 IRF1 IRF7
12 positive regulation of interferon-beta production GO:0032728 8.8 DDX3X IRF1 IRF7

Sources for Venezuelan Equine Encephalitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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