MCID: VNZ002
MIFTS: 48

Venezuelan Equine Encephalitis

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Venezuelan Equine Encephalitis

MalaCards integrated aliases for Venezuelan Equine Encephalitis:

Name: Venezuelan Equine Encephalitis 12 54 15 17
Encephalomyelitis, Venezuelan Equine 45
Venezuelan Equine Encephalomyelitis 74
Encephalitis Venezuelan Equine 56
Venezuelan Equine Fever 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9584
ICD9CM 36 066.2
MeSH 45 D004685
NCIt 51 C35121
SNOMED-CT 69 89990001
ICD10 34 A92.2
UMLS 74 C0014078

Summaries for Venezuelan Equine Encephalitis

Disease Ontology : 12 A viral infectious disease that results in inflammation located in brain of horses and humans, has material basis in Venezuelan equine encephalitis virus, which is transmitted by Culex mosquitoes. The infection has symptom fever, has symptom chills, has symptom malaise, has symptom severe headache, has symptom photophobia, and has symptom myalgia in the legs and lumbosacral region.

MalaCards based summary : Venezuelan Equine Encephalitis, also known as encephalomyelitis, venezuelan equine, is related to japanese encephalitis and encephalitis, and has symptoms including photophobia, fever and chills. An important gene associated with Venezuelan Equine Encephalitis is RPSA (Ribosomal Protein SA), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Vaccines and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include brain, t cells and kidney, and related phenotypes are hematopoietic system and neoplasm

Related Diseases for Venezuelan Equine Encephalitis

Graphical network of the top 20 diseases related to Venezuelan Equine Encephalitis:



Diseases related to Venezuelan Equine Encephalitis

Symptoms & Phenotypes for Venezuelan Equine Encephalitis

Symptoms:

12
  • photophobia
  • fever
  • chills
  • malaise
  • severe headache
  • myalgia in the legs

MGI Mouse Phenotypes related to Venezuelan Equine Encephalitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.43 IFNB1 IRF1 IRF7 LGALS3 RPSA STAT1
2 neoplasm MP:0002006 9.02 IFNB1 IRF1 LGALS3 SAT1 STAT1

Drugs & Therapeutics for Venezuelan Equine Encephalitis

Drugs for Venezuelan Equine Encephalitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 2,Phase 1
2 Immunologic Factors Phase 2,Phase 1
3
Aluminum hydroxide Approved, Investigational Phase 1 21645-51-2
4
Aluminum sulfate Approved Phase 1 10043-01-3
5 Mitogens Phase 1
6 Antacids Phase 1
7 Gastrointestinal Agents Phase 1
8 Anti-Ulcer Agents Phase 1
9 Adjuvants, Immunologic Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety and Immunogenicity of Venezuelan Equine Encephalomyelitis Vaccine in Healthy Adults Recruiting NCT03051386 Phase 2
2 Safety and Immunogenicity of Venezuelan Equine Encephalomyelitis Vaccine (VEE C-84) as a Booster to VEE TC-83 Active, not recruiting NCT00582088 Phase 2
3 Safety and Immunogenicity Study of the Venezuelan Equine Encephalomyelitis Vaccine Enrolling by invitation NCT00582504 Phase 2
4 Safety and Immunogenicity Study of Venezuelan Equine Encephalomyelitis (VEE) Vaccine as Booster Vaccine in Adults Not yet recruiting NCT03531242 Phase 2
5 Study of a DNA-based Venezuelan Equine Encephalitis Virus DNA Vaccine Administered by Electroporation in Healthy Volunteers Completed NCT01984983 Phase 1
6 A Phase I Study To Evaluate The Antitumor Activity And Safety Of AVX901 Completed NCT01526473 Phase 1
7 Venezuelan Equine Encephalitis Monovalent Virus-Like Particle Vaccine Recruiting NCT03776994 Phase 1
8 VRC 313: A Trivalent Virus-like Particle (VLP) Encephalitis Vaccine (WEVEE) in Healthy Adults Recruiting NCT03879603 Phase 1
9 Safety, Tolerability and Immunogenicity of the Venezuelan Equine Encephalitis (VEE) Attenuated Live-Virus Vaccine Withdrawn NCT00109304 Phase 1

Search NIH Clinical Center for Venezuelan Equine Encephalitis

Cochrane evidence based reviews: encephalomyelitis, venezuelan equine

Genetic Tests for Venezuelan Equine Encephalitis

Anatomical Context for Venezuelan Equine Encephalitis

MalaCards organs/tissues related to Venezuelan Equine Encephalitis:

42
Brain, T Cells, Kidney, Testes, Spleen, Pancreas, Whole Blood

The Foundational Model of Anatomy Ontology organs/tissues related to Venezuelan Equine Encephalitis:

20
Brain Of Horses

Publications for Venezuelan Equine Encephalitis

Articles related to Venezuelan Equine Encephalitis:

(show top 50) (show all 457)
# Title Authors Year
1
Novel RU486 (mifepristone) analogues with increased activity against Venezuelan Equine Encephalitis Virus but reduced progesterone receptor antagonistic activity. ( 30796232 )
2019
2
Approved drugs screening against the nsP1 capping enzyme of Venezuelan equine encephalitis virus using an immuno-based assay. ( 30639438 )
2019
3
Human cathelicidin peptide LL-37 as a therapeutic antiviral targeting Venezuelan equine encephalitis virus infections. ( 30738837 )
2019
4
Proteolytic cleavage of host proteins by the Group IV viral proteases of Venezuelan equine encephalitis virus and zika virus. ( 30742841 )
2019
5
Self-Amplifying RNA Vaccines for Venezuelan Equine Encephalitis Virus Induce Robust Protective Immunogenicity in Mice. ( 30770173 )
2019
6
Current Understanding of the Molecular Basis of Venezuelan Equine Encephalitis Virus Pathogenesis and Vaccine Development. ( 30781656 )
2019
7
Development of a Broadly Accessible Venezuelan Equine Encephalitis Virus Replicon Particle Vaccine Platform. ( 29540599 )
2018
8
Protein Phosphatase 1I+ Interacts with Venezuelan Equine Encephalitis Virus Capsid Protein and Regulates Viral Replication through Modulation of Capsid Phosphorylation. ( 29769351 )
2018
9
Low-fidelity Venezuelan equine encephalitis virus polymerase mutants to improve live-attenuated vaccine safety and efficacy. ( 29593882 )
2018
10
Evaluation of the inactivation of Venezuelan equine encephalitis virus by several common methods. ( 29407211 )
2018
11
Identification of novel antivirals inhibiting recognition of Venezuelan equine encephalitis virus capsid protein by the Importin I+/I^1 heterodimer through high-throughput screening. ( 29337164 )
2018
12
Venezuelan Equine Encephalitis Virus Capsid Implicated in Infection-Induced Cell Cycle Delay in vitro. ( 30631316 )
2018
13
Eco-epidemiology of the Venezuelan equine encephalitis virus in bats of Córdoba and Sucre, Colombia. ( 30578748 )
2018
14
The genetic adjuvant IL-12 enhances the protective efficacy of a DNA vaccine for Venezuelan equine encephalitis virus delivered by intramuscular injection in mice. ( 30268913 )
2018
15
Comparison of Aerosol- and Percutaneous-acquired Venezuelan Equine Encephalitis in Humans and Nonhuman Primates for Suitability in Predicting Clinical Efficacy under the Animal Rule. ( 30282570 )
2018
16
Author Correction: Novel inhibitors targeting Venezuelan equine encephalitis virus capsid protein identified using In Silico Structure-Based-Drug-Design. ( 30177745 )
2018
17
Repurposed FDA-Approved drug sorafenib reduces replication of Venezuelan equine encephalitis virus and other alphaviruses. ( 29981794 )
2018
18
Potential Sympatric Vectors and Mammalian Hosts of Venezuelan Equine Encephalitis Virus in Southern Mexico. ( 28384059 )
2017
19
An immunoinformatics-derived DNA vaccine encoding human class II T cell epitopes of Ebola virus, Sudan virus, and Venezuelan equine encephalitis virus is immunogenic in HLA transgenic mice. ( 28575582 )
2017
20
Live, Attenuated Venezuelan Equine Encephalitis Virus Vaccine (TC83) Causes Persistent Brain Infection in Mice with Non-functional I+I^ T-Cells. ( 28184218 )
2017
21
Antibody Preparations from Human Transchromosomic Cows Exhibit Prophylactic and Therapeutic Efficacy against Venezuelan Equine Encephalitis Virus. ( 28468884 )
2017
22
Ablation of Programmed -1 Ribosomal Frameshifting in Venezuelan Equine Encephalitis Virus Results in Attenuated Neuropathogenicity. ( 27852852 )
2017
23
Mutation of Asn-475 in the Venezuelan Equine Encephalitis Virus nsP2 Cysteine Protease Leads to a Self-Inhibited State. ( 29064679 )
2017
24
Novel inhibitors targeting Venezuelan equine encephalitis virus capsid protein identified using In Silico Structure-Based-Drug-Design. ( 29255256 )
2017
25
Altered mitochondrial dynamics as a consequence of Venezuelan Equine Encephalitis Virus infection. ( 28075229 )
2017
26
Differential host gene responses from infection with neurovirulent and partially-neurovirulent strains of Venezuelan equine encephalitis virus. ( 28446152 )
2017
27
Evolution and spread of Venezuelan equine encephalitis complex alphavirus in the Americas. ( 28771475 )
2017
28
Venezuelan Equine Encephalitis Virus Capsid-The Clever Caper. ( 28961161 )
2017
29
Venezuelan equine encephalitis: How likely are we to see the next epidemic? ( 28242351 )
2017
30
Development of high-throughput and high sensitivity capillary gel electrophoresis platform method for Western, Eastern, and Venezuelan equine encephalitis (WEVEE) virus like particles (VLPs) purity determination and characterization. ( 28842921 )
2017
31
Human transcriptome response to immunization with live-attenuated Venezuelan equine encephalitis virus vaccine (TC-83): Analysis of whole blood. ( 27870591 )
2016
32
Epidemiology of Emergent Madariaga Encephalitis in a Region with Endemic Venezuelan Equine Encephalitis: Initial Host Studies and Human Cross-Sectional Study in Darien, Panama. ( 27101567 )
2016
33
Effect of Holding Conditions on the Detection of Chikungunya and Venezuelan Equine Encephalitis Viruses in Mosquito Pools. ( 27105216 )
2016
34
Kinetic, Mutational, and Structural Studies of the Venezuelan Equine Encephalitis Virus Nonstructural Protein 2 Cysteine Protease. ( 27030368 )
2016
35
Bibliometric assessment of global research on Venezuelan Equine Encephalitis: A latent threat for the Americas. ( 27640115 )
2016
36
1,5-Iodonaphthyl azide-inactivated V3526 protects against aerosol challenge with virulent venezuelan equine encephalitis virus. ( 27129427 )
2016
37
Host translation shutoff mediated by non-structural protein 2 is a critical factor in the antiviral state resistance of Venezuelan equine encephalitis virus. ( 27318152 )
2016
38
Venezuelan equine encephalitis virus non-structural protein 3 (nsP3) interacts with RNA helicases DDX1 and DDX3 in infected cells. ( 27105836 )
2016
39
A Phase 1 clinical trial of a DNA vaccine for Venezuelan equine encephalitis delivered by intramuscular or intradermal electroporation. ( 27206386 )
2016
40
The SD1 Subdomain of Venezuelan Equine Encephalitis Virus Capsid Protein Plays a Critical Role in Nucleocapsid and Particle Assembly. ( 26656680 )
2016
41
A novel cell-based assay to measure activity of Venezuelan equine encephalitis virus nsP2 protease. ( 27261892 )
2016
42
Engineered Mesenchymal Cells Improve Passive Immune Protection Against Lethal Venezuelan Equine Encephalitis Virus Exposure. ( 27334491 )
2016
43
Venezuelan Equine Encephalitis Virus Induces Apoptosis through the Unfolded Protein Response Activation of EGR1. ( 26792742 )
2016
44
Characterization of Genetic Variability of Venezuelan Equine Encephalitis Viruses. ( 27054586 )
2016
45
A Quantitative Real-Time RT-PCR Assay for the Detection of Venezuelan equine encephalitis virus Utilizing a Universal Alphavirus Control RNA. ( 28042576 )
2016
46
Mayaro, Oropouche and Venezuelan Equine Encephalitis viruses: Following in the footsteps of Zika? ( 27826073 )
2016
47
Genetic diversity of Venezuelan alphaviruses and circulation of a Venezuelan equine encephalitis virus subtype IAB strain during an interepizootic period. ( 25940191 )
2015
48
Demographics of natural oral infection of mosquitos by venezuelan equine encephalitis virus. ( 25589654 )
2015
49
IRES-Containing VEEV Vaccine Protects Cynomolgus Macaques from IE Venezuelan Equine Encephalitis Virus Aerosol Challenge. ( 26020513 )
2015
50
Complete coding sequences of eastern equine encephalitis virus and venezuelan equine encephalitis virus strains isolated from human cases. ( 25908124 )
2015

Variations for Venezuelan Equine Encephalitis

Expression for Venezuelan Equine Encephalitis

Search GEO for disease gene expression data for Venezuelan Equine Encephalitis.

Pathways for Venezuelan Equine Encephalitis

Pathways related to Venezuelan Equine Encephalitis according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.58 IFNB1 IL32 IRF1 IRF7 LGALS3 STAT1
2
Show member pathways
12.94 IFNB1 IL32 IRF1 IRF7 STAT1
3
Show member pathways
12.38 IFNB1 IRF1 IRF7
4 11.97 IRF1 IRF7 LGALS3 STAT1
5
Show member pathways
11.8 IFNB1 IRF1 STAT1
6
Show member pathways
11.77 IFNB1 IRF1 IRF7 STAT1
7
Show member pathways
11.75 IFNB1 IRF1 IRF7 STAT1
8 11.74 IFNB1 IRF1 IRF7
9 11.52 IFNB1 IRF1 IRF7
10 11.44 IRF1 STAT1
11 11.38 IFNB1 IRF7
12 11.3 LGALS3 STAT1
13
Show member pathways
10.82 IRF7 STAT1
14 10.37 IFNB1 IRF1 STAT1

GO Terms for Venezuelan Equine Encephalitis

Biological processes related to Venezuelan Equine Encephalitis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.8 IFNB1 IRF1 IRF7 STAT1
2 viral process GO:0016032 9.7 IRF7 RPSA STAT1
3 cytokine-mediated signaling pathway GO:0019221 9.65 IFNB1 IL32 STAT1
4 defense response to virus GO:0051607 9.56 IFNB1 IRF1 IRF7 STAT1
5 epithelial cell differentiation GO:0030855 9.51 LGALS3 RPSA
6 interferon-gamma-mediated signaling pathway GO:0060333 9.5 IRF1 IRF7 STAT1
7 positive regulation of type I interferon production GO:0032481 9.46 IRF1 IRF7
8 positive regulation of interferon-beta production GO:0032728 9.43 IRF1 IRF7
9 positive regulation of interferon-alpha production GO:0032727 9.4 IRF7 STAT1
10 regulation of adaptive immune response GO:0002819 9.37 IRF1 IRF7
11 regulation of MyD88-dependent toll-like receptor signaling pathway GO:0034124 9.16 IRF1 IRF7
12 cellular response to interferon-beta GO:0035458 9.13 IFNB1 IRF1 STAT1
13 type I interferon signaling pathway GO:0060337 8.92 IFNB1 IRF1 IRF7 STAT1

Molecular functions related to Venezuelan Equine Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.13 IRF1 IRF7 STAT1
2 laminin binding GO:0043236 8.62 LGALS3 RPSA

Sources for Venezuelan Equine Encephalitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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