MCID: VNZ002
MIFTS: 45

Venezuelan Equine Encephalitis

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Venezuelan Equine Encephalitis

MalaCards integrated aliases for Venezuelan Equine Encephalitis:

Name: Venezuelan Equine Encephalitis 12 20 15 17
Venezuelan Equine Fever 12 32
Encephalomyelitis, Venezuelan Equine 44
Venezuelan Equine Encephalomyelitis 70
Encephalitis Venezuelan Equine 54

Classifications:



External Ids:

Disease Ontology 12 DOID:9584
ICD9CM 34 066.2
MeSH 44 D004685
NCIt 50 C35121
SNOMED-CT 67 89990001
ICD10 32 A92.2
UMLS 70 C0014078

Summaries for Venezuelan Equine Encephalitis

Disease Ontology : 12 A viral infectious disease that results in inflammation located in brain of horses and humans, has material basis in Venezuelan equine encephalitis virus, which is transmitted by Culex mosquitoes. The infection has symptom fever, has symptom chills, has symptom malaise, has symptom severe headache, has symptom photophobia, and has symptom myalgia in the legs and lumbosacral region.

MalaCards based summary : Venezuelan Equine Encephalitis, also known as venezuelan equine fever, is related to encephalitis and tick-borne encephalitis, and has symptoms including photophobia, fever and chills. An important gene associated with Venezuelan Equine Encephalitis is RPSA (Ribosomal Protein SA), and among its related pathways/superpathways are Innate Immune System and TGF-Beta Pathway. The drugs Aluminum sulfate and Aluminum hydroxide have been mentioned in the context of this disorder. Affiliated tissues include brain of horses, t cells and pancreas, and related phenotypes are Reduced mammosphere formation and mortality/aging

Related Diseases for Venezuelan Equine Encephalitis

Diseases related to Venezuelan Equine Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 148)
# Related Disease Score Top Affiliating Genes
1 encephalitis 31.1 XPO1 RPSA PPP1CA IFNB1 DDX3X DDX1
2 tick-borne encephalitis 30.4 IFNB1 IFNA1 CXCL10
3 stomatitis 30.4 IFNG IFNB1 IFNA1
4 ebola hemorrhagic fever 30.1 IFNB1 IFNA1 CXCL10
5 lyme disease 30.1 IRF7 IFNB1 IFNA1
6 vaccinia 29.8 STAT2 STAT1 IRF7 IFNB1 IFNA1
7 viral encephalitis 29.7 IFNB1 IFNA1 CXCL10 CCL2
8 human immunodeficiency virus type 1 29.6 STAT1 IFNG CXCL10 CCL2
9 yellow fever 29.6 STAT1 IRF7 IFNB1 CXCL10 CCL2
10 retinal detachment 29.3 IFNG CXCL10 CCL2
11 severe acute respiratory syndrome 29.2 IFNG IFNB1 IFNA1 CXCL10 CCL2
12 herpes simplex 29.2 STAT2 STAT1 IRF7 IFNB1 IFNA1
13 japanese encephalitis 29.0 STAT2 STAT1 IFNB1 IFNA1 CXCL10 CCL2
14 immune deficiency disease 28.5 XPO1 STAT1 IRF1 IFNG IFNB1 IFNA1
15 mumps 28.2 STAT2 STAT1 IRF1 IFNG IFNB1 IFNA1
16 viral infectious disease 27.7 STAT2 STAT1 IRF7 IRF1 IFNG IFNB1
17 western equine encephalitis 10.7
18 eastern equine encephalitis 10.7
19 chikungunya 10.6
20 meningoencephalitis 10.5
21 st. louis encephalitis 10.5
22 disease by infectious agent 10.5
23 lymphopenia 10.4
24 dengue virus 10.4
25 rift valley fever 10.4
26 coccidioidomycosis 10.4
27 mouth disease 10.4
28 glioma susceptibility 1 10.3
29 west nile virus 10.3
30 malignant astrocytoma 10.3
31 oral erosive lichen 10.2 IFNB1 IFNA1
32 middle east respiratory syndrome 10.2
33 anthrax disease 10.2
34 neuroblastoma 10.2
35 rubella 10.2
36 cytokine deficiency 10.2
37 parainfluenza virus type 3 10.2 IFNB1 IFNA1
38 respiratory syncytial virus infectious disease 10.1 IRF1 IFNB1
39 retinoblastoma 10.1
40 hydrops fetalis, nonimmune 10.1
41 ocular motor apraxia 10.1
42 fragile x syndrome 10.1
43 cataract 26, multiple types 10.1
44 lymphatic malformation 7 10.1
45 helix syndrome 10.1
46 foodborne botulism 10.1
47 exanthem 10.1
48 porencephaly 10.1
49 hydrocephalus 10.1
50 amnestic disorder 10.1

Graphical network of the top 20 diseases related to Venezuelan Equine Encephalitis:



Diseases related to Venezuelan Equine Encephalitis

Symptoms & Phenotypes for Venezuelan Equine Encephalitis

Symptoms:

12
  • photophobia
  • fever
  • chills
  • malaise
  • severe headache
  • myalgia in the legs

GenomeRNAi Phenotypes related to Venezuelan Equine Encephalitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 CCL2 DDX1 KPNB1 PPP1CA RPSA STAT1

MGI Mouse Phenotypes related to Venezuelan Equine Encephalitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.44 CXCL10 DDX1 DDX3X IFNG IRF1 IRF7

Drugs & Therapeutics for Venezuelan Equine Encephalitis

Drugs for Venezuelan Equine Encephalitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aluminum sulfate Approved Phase 1 10043-01-3
2
Aluminum hydroxide Approved, Investigational Phase 1 21645-51-2
3 Gastrointestinal Agents Phase 1
4 Adjuvants, Immunologic Phase 1
5 Antacids Phase 1
6 Anti-Ulcer Agents Phase 1
7 Anti-Bacterial Agents Phase 1
8 Anti-Infective Agents Phase 1
9 Pharmaceutical Solutions Phase 1
10 Immunologic Factors Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase 2 Open-Label, Safety and Immunogenicity Study of a Single Dose of Venezuelan Equine Encephalomyelitis Vaccine, Live, Attenuated, Dried, TC-83, NDBR-102, as Primary Immunization in Healthy Adults At Risk for Exposure to Virulent Venezuelan Equine Encephalomyelitis Virus Active, not recruiting NCT00582504 Phase 2
2 A Phase 2 Open-Label, Safety and Immunogenicity Study of Venezuelan Equine Encephalomyelitis Vaccine, Inactivated, Dried, C-84, TSI-GSD 205 When Used as a Booster After TC-83 Primary Immunization in Healthy Adults At-Risk for Exposure to Virulent Venezuelan Equine Encephalomyelitis Virus Active, not recruiting NCT00582088 Phase 2
3 Phase 2 Open-Label Safety and Immunogenicity Study of the Venezuelan Equine Encephalomyelitis (VEE) Vaccine, Live Attenuated, Dried, TC-83, NDBR 102, Lot 4, Run 3, as Primary Vaccination in Healthy Adult Subjects at Risk of Exposure to VEE Virus Active, not recruiting NCT03051386 Phase 2
4 Phase 2 Open-Label Safety and Immunogenicity Study of the Venezuelan Equine Encephalomyelitis (VEE) Vaccine, Inactivated, Dried, C-84, TSI-GSD 205, Lot 7, Run 1, as Booster Vaccination in Adult Subjects at Risk of Exposure to VEE Virus Not yet recruiting NCT03531242 Phase 2
5 A Phase I, Randomized, Observer-blind, Placebo Controlled Study to Assess the Safety, Reactogenicity, and Immunogenicity of a Venezuelan Equine Encephalitis DNA Vaccine Candidate Administered Intramuscularly or Intradermally by Electroporation to Healthy Adults Completed NCT01984983 Phase 1
6 A Phase 1 Open Label, Dose-Escalation Clinical Trial to Evaluate the Safety and Immunogenicity of a Trivalent Virus-Like Particle (VLP) Encephalitis Vaccine, VRC-WEVVLP073-00-VP, in Healthy Adults Completed NCT03879603 Phase 1
7 A Phase 1 Trial to Evaluate the Safety, Immunogenicity, and Reactogenicity of Heterologous and Homologous Chimpanzee Adenovirus and Self-Amplifying mRNA Prime-Boost Prophylactic Vaccines Against SARS-CoV-2 in Healthy Adults Recruiting NCT04776317 Phase 1
8 A Phase 1 Dose Escalation Study to Assess the Safety and Immunogenicity of a Monovalent Virus-Like Particle (VLP) Venezuelan Equine Encephalitis Vaccine in Healthy Adults Active, not recruiting NCT03776994 Phase 1
9 Safety, Tolerability and Immunogenicity of the Venezuelan Equine Encephalitis (VEE) Attenuated Live-Virus Vaccine VEE IA/B V3526 in VEE-Naive Healthy Volunteers After Single Dose Subcutaneous Administration Withdrawn NCT00109304 Phase 1

Search NIH Clinical Center for Venezuelan Equine Encephalitis

Cochrane evidence based reviews: encephalomyelitis, venezuelan equine

Genetic Tests for Venezuelan Equine Encephalitis

Anatomical Context for Venezuelan Equine Encephalitis

The Foundational Model of Anatomy Ontology organs/tissues related to Venezuelan Equine Encephalitis:

19
Brain Of Horses

MalaCards organs/tissues related to Venezuelan Equine Encephalitis:

40
T Cells, Pancreas, Prostate, Whole Blood, Lymph Node, Bone Marrow, Bone

Publications for Venezuelan Equine Encephalitis

Articles related to Venezuelan Equine Encephalitis:

(show top 50) (show all 975)
# Title Authors PMID Year
1
C-terminal fragment of human laminin-binding protein contains a receptor domain for venezuelan equine encephalitis and tick-borne encephalitis viruses. 61 54
19961413 2009
2
Toll-like receptor 4 mediates blood-brain barrier permeability and disease in C3H mice during Venezuelan equine encephalitis virus infection. 61
33487119 2021
3
Venezuelan Equine Encephalitis Complex Alphavirus in Bats, French Guiana. 61
33756099 2021
4
A comprehensive review on the antiviral activities of chalcones. 61
33232192 2021
5
Proteomic Discovery of VEEV E2-Host Partner Interactions Identifies GRP78 Inhibitor HA15 as a Potential Therapeutic for Alphavirus Infections. 61
33801554 2021
6
The transcriptional landscape of Venezuelan equine encephalitis virus (TC-83) infection. 61
33788849 2021
7
Resveratrol Inhibits Venezuelan Equine Encephalitis Virus Infection by Interfering with the AKT/GSK Pathway. 61
33673026 2021
8
The Alphaviral Capsid Protein Inhibits IRAK1-Dependent TLR Signaling. 61
33673546 2021
9
Antivirals that target the host IMPα/β1-virus interface. 61
33439253 2021
10
The broad spectrum host-directed agent ivermectin as an antiviral for SARS-CoV-2 ? 61
33341233 2021
11
Stabilization of a Broadly Neutralizing Anti-Chikungunya Virus Single Domain Antibody. 61
33585527 2021
12
Alphavirus-Based Antigen Preparation. 61
32959241 2021
13
Endemic and Epidemic Human Alphavirus Infections in Eastern Panama: An Analysis of Population-Based Cross-Sectional Surveys. 61
33124532 2020
14
BIKE regulates dengue virus infection and is a cellular target for broad-spectrum antivirals. 61
33137362 2020
15
An Environmental Niche Model to Estimate the Potential Presence of Venezuelan Equine Encephalitis Virus in Costa Rica. 61
33396763 2020
16
Novel NMR Assignment Strategy Reveals Structural Heterogeneity in Solution of the nsP3 HVD Domain of Venezuelan Equine Encephalitis Virus. 61
33321815 2020
17
LDLRAD3 is a receptor for Venezuelan equine encephalitis virus. 61
33208938 2020
18
Synthetic Host Defense Peptides Inhibit Venezuelan Equine Encephalitis Virus Replication and the Associated Inflammatory Response. 61
33293592 2020
19
Vinyl Sulfone-Based Inhibitors of Nonstructural Protein 2 Block the Replication of Venezuelan Equine Encephalitis Virus. 61
33214821 2020
20
Serosurvey of Eastern, Western, and Venezuelan Equine Encephalitis Viruses in Wild Boars (Sus scrofa), Hunting Dogs, and Hunters of Brazil. 61
32644885 2020
21
Controlling the Switch from Neurogenesis to Pluripotency during Marmoset Monkey Somatic Cell Reprogramming with Self-Replicating mRNAs and Small Molecules. 61
33167468 2020
22
Optimized Approaches for the Induction of Putative Canine Induced Pluripotent Stem Cells from Old Fibroblasts Using Synthetic RNAs. 61
33050577 2020
23
Producing physicochemical property consensus alphavirus protein antigens for broad spectrum vaccine design. 61
32800880 2020
24
Mutations on VEEV nsP1 relate RNA capping efficiency to ribavirin susceptibility. 61
32750467 2020
25
Specificity Studies of the Venezuelan Equine Encephalitis Virus Non-Structural Protein 2 Protease Using Recombinant Fluorescent Substrates. 61
33081394 2020
26
Emergence and Magnitude of ML336 Resistance in Venezuelan Equine Encephalitis Virus Depend on the Microenvironment. 61
32878897 2020
27
Venezuelan Equine Encephalitis Virus nsP3 Phosphorylation Can Be Mediated by IKKβ Kinase Activity and Abrogation of Phosphorylation Inhibits Negative-Strand Synthesis. 61
32933112 2020
28
Clinical and Serological Findings of Madariaga and Venezuelan Equine Encephalitis Viral Infections: A Follow-up Study 5 Years After an Outbreak in Panama. 61
33005697 2020
29
Rationally Attenuated Vaccines for Venezuelan Equine Encephalitis Protect Against Epidemic Strains with a Single Dose. 61
32887313 2020
30
Antiviral Strategies against Arthritogenic Alphaviruses. 61
32906603 2020
31
A small molecule inhibitor of MyD88 exhibits broad spectrum antiviral activity by up regulation of type I interferon. 61
32621945 2020
32
Ivermectin: a systematic review from antiviral effects to COVID-19 complementary regimen. 61
32533071 2020
33
Ivermectin as a Broad-Spectrum Host-Directed Antiviral: The Real Deal? 61
32942671 2020
34
National Seroprevalence and Risk Factors for Eastern Equine Encephalitis and Venezuelan Equine Encephalitis in Costa Rica. 61
32797803 2020
35
Laboratory transmission potential of British mosquitoes for equine arboviruses. 61
32787904 2020
36
Glucosamine-NISV delivers antibody across the blood-brain barrier: Optimization for treatment of encephalitic viruses. 61
32512014 2020
37
Complete genomic sequences of Venezuelan equine encephalitis virus subtype IIID isolates from mosquitoes. 61
32417973 2020
38
Letter to the Editor: Venezuelan Equine Encephalitis virus 1B Invasion and Epidemic Control-South Texas, 1971. 61
32580287 2020
39
Nanoplasmid Vectors Co-expressing Innate Immune Agonists Enhance DNA Vaccines for Venezuelan Equine Encephalitis Virus and Ebola Virus. 61
32296729 2020
40
A novel rabies vaccine based on infectious propagating particles derived from hybrid VEEV-Rabies replicon. 61
32512518 2020
41
A Low Fidelity Virus Shows Increased Recombination during the Removal of an Alphavirus Reporter Gene. 61
32575413 2020
42
Measuring Alphavirus Fidelity Using Non-Infectious Virus Particles. 61
32429270 2020
43
Venezuelan equine encephalitis virus: the problem is not over for tropical America. 61
32429942 2020
44
Venezuelan equine encephalitis vaccine with rearranged genome resists reversion and protects non-human primates from viremia after aerosol challenge. 61
32085953 2020
45
Evaluation of altered environmental conditions as a decontamination approach for nonspore-forming biological agents. 61
31782200 2020
46
Bivalent Junin & Machupo experimental vaccine based on alphavirus RNA replicon vector. 61
32111526 2020
47
Advanced Safety and Genetic Stability in Mice of a Novel DNA-Launched Venezuelan Equine Encephalitis Virus Vaccine with Rearranged Structural Genes. 61
32121666 2020
48
Molecular and cellular evidence of natural Venezuelan equine encephalitis virus infection in frugivorous bats in Colombia. 61
32367955 2020
49
A new inactivation method to facilitate cryo-EM of enveloped, RNA viruses requiring high containment: A case study using Venezuelan Equine Encephalitis Virus (VEEV). 61
31786314 2020
50
Protein Kinase C subtype δ interacts with Venezuelan equine encephalitis virus capsid protein and regulates viral RNA binding through modulation of capsid phosphorylation. 61
32150585 2020

Variations for Venezuelan Equine Encephalitis

Expression for Venezuelan Equine Encephalitis

Search GEO for disease gene expression data for Venezuelan Equine Encephalitis.

Pathways for Venezuelan Equine Encephalitis

Pathways related to Venezuelan Equine Encephalitis according to GeneCards Suite gene sharing:

(show all 35)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.93 STAT2 STAT1 KPNB1 KPNA2 KPNA1 IRF7
2
Show member pathways
13.47 STAT2 STAT1 KPNA1 IRF1 IFNG IFNB1
3
Show member pathways
13.14 STAT2 STAT1 IRF7 IFNG IFNB1 IFNA1
4
Show member pathways
13.14 STAT2 STAT1 KPNB1 KPNA2 KPNA1 IRF7
5
Show member pathways
12.89 STAT2 STAT1 IRF1 IFNB1 IFNA1
6
Show member pathways
12.87 STAT2 STAT1 IRF7 IFNB1 IFNA1 CCL2
7 12.7 STAT2 STAT1 PPP1CA IRF7 IFNG IFNB1
8
Show member pathways
12.68 XPO1 RPSA KPNB1 KPNA2 KPNA1
9
Show member pathways
12.48 IRF7 IRF1 IFNG IFNB1 IFNA1 DDX3X
10
Show member pathways
12.46 IRF7 IFNB1 IFNA1 CXCL10
11 12.44 STAT2 STAT1 IRF7 IRF1 IFNG IFNA1
12
Show member pathways
12.41 XPO1 STAT2 STAT1 KPNA2 KPNA1 IRF7
13
Show member pathways
12.35 STAT2 STAT1 IFNG IFNB1 IFNA1
14 12.21 STAT2 STAT1 IRF7 IFNB1 IFNA1 CCL2
15
Show member pathways
12.21 STAT2 STAT1 IRF7 IRF1 IFNG IFNB1
16
Show member pathways
12.18 STAT2 STAT1 IFNG IFNB1 IFNA1
17 12.17 STAT1 IFNG IFNB1 IFNA1
18
Show member pathways
12.15 STAT1 IRF1 IFNG IFNB1 CXCL10
19 12.11 IRF7 IRF1 IFNB1 IFNA1
20 11.93 IRF1 IFNB1 CXCL10 CCL2
21 11.91 IFNG CXCL10 CCL2
22 11.9 IRF7 IRF1 IFNG IFNB1
23 11.87 STAT2 STAT1 IFNG IFNB1 IFNA1
24
Show member pathways
11.81 STAT2 STAT1 KPNB1 KPNA2 KPNA1 IRF7
25 11.8 KPNB1 KPNA2 KPNA1
26
Show member pathways
11.79 STAT1 IRF1 IFNG
27 11.73 STAT1 IRF1 IFNG
28
Show member pathways
11.69 STAT2 STAT1 IFNG
29 11.51 XPO1 KPNB1 KPNA2
30 11.32 STAT1 KPNB1 KPNA2
31 11.2 STAT2 STAT1 IRF1 IFNG IFNB1 CXCL10
32
Show member pathways
11.11 STAT2 STAT1 IRF7
33 10.94 KPNB1 KPNA2
34 10.94 STAT1 CCL2
35 10.85 XPO1 KPNB1 KPNA2 KPNA1

GO Terms for Venezuelan Equine Encephalitis

Cellular components related to Venezuelan Equine Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.93 XPO1 STAT2 STAT1 RPSA PPP1CA KPNB1
2 nucleoplasm GO:0005654 9.73 XPO1 STAT2 STAT1 RPSA PPP1CA KPNB1
3 cytoplasmic stress granule GO:0010494 9.43 KPNB1 DDX3X DDX1
4 host cell GO:0043657 8.92 XPO1 KPNB1 KPNA2 KPNA1

Biological processes related to Venezuelan Equine Encephalitis according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.12 STAT1 IRF7 IRF1 IFNB1 DDX3X CXCL10
2 cell surface receptor signaling pathway GO:0007166 9.93 IFNG IFNB1 CXCL10 CCL2
3 cytokine-mediated signaling pathway GO:0019221 9.88 STAT2 STAT1 IFNB1 IFNA1 CXCL10 CCL2
4 defense response GO:0006952 9.83 STAT2 STAT1 IFNB1 IFNA1 CXCL10
5 protein import into nucleus GO:0006606 9.8 KPNB1 KPNA2 KPNA1
6 interferon-gamma-mediated signaling pathway GO:0060333 9.78 STAT1 IRF7 IRF1 IFNG
7 intracellular transport of virus GO:0075733 9.76 XPO1 KPNB1 KPNA1
8 humoral immune response GO:0006959 9.76 IFNG IFNB1 IFNA1 CCL2
9 positive regulation of interferon-beta production GO:0032728 9.75 IRF7 IRF1 DDX3X
10 response to exogenous dsRNA GO:0043330 9.74 IFNB1 IFNA1 DDX1
11 response to virus GO:0009615 9.73 IRF7 IFNG IFNB1 DDX3X DDX1 CXCL10
12 positive regulation of interferon-alpha production GO:0032727 9.72 STAT1 IRF7 DDX3X
13 cellular response to interferon-beta GO:0035458 9.71 STAT1 IRF1 IFNB1
14 positive regulation of peptidyl-serine phosphorylation of STAT protein GO:0033141 9.7 IFNG IFNB1 IFNA1
15 viral process GO:0016032 9.7 XPO1 STAT2 STAT1 RPSA PPP1CA KPNB1
16 NLS-bearing protein import into nucleus GO:0006607 9.69 KPNB1 KPNA2 KPNA1
17 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.67 STAT1 IFNG CCL2
18 natural killer cell activation involved in immune response GO:0002323 9.65 IFNB1 IFNA1
19 apoptotic DNA fragmentation GO:0006309 9.64 KPNB1 KPNA1
20 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.63 STAT1 IFNG
21 type I interferon signaling pathway GO:0060337 9.63 STAT2 STAT1 IRF7 IRF1 IFNB1 IFNA1
22 postsynapse to nucleus signaling pathway GO:0099527 9.62 KPNA2 KPNA1
23 JAK-STAT cascade GO:0007259 9.62 STAT2 STAT1 IFNG CCL2
24 regulation of adaptive immune response GO:0002819 9.61 IRF7 IRF1
25 positive regulation of NMDA glutamate receptor activity GO:1904783 9.61 IFNG CCL2
26 protein localization to cytoplasmic stress granule GO:1903608 9.6 DDX3X DDX1
27 regulation of DNA recombination GO:0000018 9.59 KPNA2 KPNA1
28 regulation of MyD88-dependent toll-like receptor signaling pathway GO:0034124 9.56 IRF7 IRF1
29 modulation by virus of host process GO:0019054 9.54 KPNB1 KPNA2 KPNA1
30 defense response to virus GO:0051607 9.28 STAT2 STAT1 IRF7 IRF1 IFNG IFNB1

Molecular functions related to Venezuelan Equine Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.19 XPO1 STAT2 STAT1 RPSA PPP1CA KPNB1
2 Ran GTPase binding GO:0008536 9.37 XPO1 KPNB1
3 cytokine activity GO:0005125 9.35 IFNG IFNB1 IFNA1 CXCL10 CCL2
4 nuclear localization sequence binding GO:0008139 9.33 KPNB1 KPNA2 KPNA1
5 type I interferon receptor binding GO:0005132 9.32 IFNB1 IFNA1
6 nuclear import signal receptor activity GO:0061608 8.8 KPNB1 KPNA2 KPNA1

Sources for Venezuelan Equine Encephalitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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