MCID: VNS003
MIFTS: 54

Venous Insufficiency

Categories: Blood diseases, Cardiovascular diseases

Aliases & Classifications for Venous Insufficiency

MalaCards integrated aliases for Venous Insufficiency:

Name: Venous Insufficiency 12 29 44 15 73
Peripheral Venous Insufficiency 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10128
ICD9CM 35 459.81
MeSH 44 D014689
NCIt 50 C127822
SNOMED-CT 68 20696009
ICD10 33 I87.2
UMLS 73 C0042485

Summaries for Venous Insufficiency

Disease Ontology : 12 A vein disease that is characterized by impaired flow of blood through the veins.

MalaCards based summary : Venous Insufficiency, also known as peripheral venous insufficiency, is related to chronic venous insufficiency and lipodermatosclerosis. An important gene associated with Venous Insufficiency is PLAT (Plasminogen Activator, Tissue Type), and among its related pathways/superpathways are Innate Immune System and Integrin Pathway. The drugs Hesperidin and Polidocanol have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and bone, and related phenotypes are cardiovascular system and homeostasis/metabolism

Related Diseases for Venous Insufficiency

Diseases in the Venous Insufficiency family:

Chronic Venous Insufficiency

Diseases related to Venous Insufficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 211)
# Related Disease Score Top Affiliating Genes
1 chronic venous insufficiency 32.7 VCAM1 TIMP1 SERPINE1 SELP SELL PLAT
2 lipodermatosclerosis 32.3 PLAT MMP1
3 post-thrombotic syndrome 32.2 F2 ICAM1 SERPINE1
4 multiple sclerosis 30.7 ICAM1 ITGA4 MMP9 TIMP1 VCAM1
5 varicose veins 30.0 VWF TIMP1 MMP9 MMP1 F2
6 thrombophlebitis 29.9 F2 PLAT SERPINE1
7 vein disease 29.9 F2 PLAT SERPINE1
8 chronic venous leg ulcers 29.9 ITGA4 TIMP1
9 thrombosis 29.8 VWF SERPINE1 SELP PLAT F2
10 thrombophilia due to thrombin defect 29.8 VWF SERPINE1 PLAT F2
11 arteriosclerosis obliterans 29.5 ICAM1 SELP VCAM1
12 thrombophilia 29.4 F2 SERPINE1 VWF
13 pulmonary disease, chronic obstructive 29.1 CRP MMP1 MMP9 TIMP1
14 vasculitis 29.0 VWF VCAM1 SELL ICAM1 CRP
15 diabetes mellitus, noninsulin-dependent 28.8 CRP PLAT SERPINE1 VCAM1 VWF
16 arteriosclerosis 28.7 VCAM1 SERPINE1 SELP MMP9 ICAM1 CRP
17 peripheral vascular disease 28.7 VWF VCAM1 SERPINE1 SELP PLAT F2
18 systemic lupus erythematosus 28.6 VWF VCAM1 ICAM1 F2 CRP
19 vascular disease 28.5 VWF VCAM1 SERPINE1 SELP PLAT MMP9
20 heart disease 28.5 VWF SERPINE1 SELP PLAT ICAM1 F2
21 fibrinolytic defect 10.3 PLAT SERPINE1
22 plasminogen activator inhibitor-1 deficiency 10.3 PLAT SERPINE1
23 argentine hemorrhagic fever 10.3 PLAT SERPINE1
24 central serous chorioretinopathy 10.3 PLAT SERPINE1
25 intracranial embolism 10.2 F2 PLAT
26 cryptogenic cirrhosis 10.2 F2 SERPINE1
27 toxicodendron dermatitis 10.2 ICAM1 SELL
28 marantic endocarditis 10.2 PLAT F2
29 acute cor pulmonale 10.2 SERPINE1 PLAT
30 amaurosis fugax 10.2 MMP9 SERPINE1
31 autoimmune inner ear disease 10.2 MMP9 TIMP1
32 plummer's disease 10.2 SELL ICAM1
33 hydrocele 10.1 ITGA4 ICAM1
34 pediatric multiple sclerosis 10.1 MMP9 ITGA4
35 livedoid vasculitis 10.1 SERPINE1 F2
36 carotid artery thrombosis 10.1 PLAT SELP SERPINE1
37 peliosis hepatis 10.1 F2 ITGA4 SELL
38 disseminated intravascular coagulation 10.1 F2 PLAT SERPINE1
39 fungal keratitis 10.1 MMP9 TIMP1
40 lymphocytic vasculitis 10.1 ICAM1 VCAM1
41 cortical thymoma 10.1 ICAM1 VCAM1
42 conjunctival nevus 10.1 TIMP1 MMP9
43 cryptogenic organizing pneumonia 10.1 TIMP1 MMP9
44 shwartzman phenomenon 10.1 ICAM1 VCAM1
45 conjunctivochalasis 10.1 TIMP1 MMP1
46 malignant otitis externa 10.1 CRP F2
47 arthus reaction 10.1 SELL ICAM1
48 portal vein thrombosis 10.1 F2 SELP SERPINE1
49 cardiac rupture 10.1 PLAT CRP
50 chronic thromboembolic pulmonary hypertension 10.1 CRP F2

Comorbidity relations with Venous Insufficiency via Phenotypic Disease Network (PDN): (show all 23)


Acute Cystitis Aortic Valve Disease 1
Bronchitis Chronic Kidney Failure
Chronic Myocardial Ischemia Chronic Pulmonary Heart Disease
Decubitus Ulcer Deficiency Anemia
Familial Atrial Fibrillation Femoral Vein Thrombophlebitis
Generalized Atherosclerosis Heart Disease
Hypertension, Essential Hypothyroidism
Iron Deficiency Anemia Ischemic Heart Disease
Mitral Valve Disease Osteoporosis
Peripheral Vascular Disease Post-Thrombotic Syndrome
Protein-Energy Malnutrition Schizophreniform Disorder
Tinea Pedis

Graphical network of the top 20 diseases related to Venous Insufficiency:



Diseases related to Venous Insufficiency

Symptoms & Phenotypes for Venous Insufficiency

MGI Mouse Phenotypes related to Venous Insufficiency:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.23 CRP F2 ICAM1 ITGA4 MMP9 PLAT
2 homeostasis/metabolism MP:0005376 10.15 CRP F2 ICAM1 MMP1 MMP9 PLAT
3 hematopoietic system MP:0005397 10.14 F2 ICAM1 ITGA4 MMP9 PLAT SELL
4 immune system MP:0005387 10.13 CRP F2 ICAM1 ITGA4 MMP1 MMP9
5 growth/size/body region MP:0005378 10.09 F2 ICAM1 MMP9 PLAT SELL SELP
6 mortality/aging MP:0010768 9.85 F2 ICAM1 ITGA4 MMP9 PLAT SELP
7 integument MP:0010771 9.8 F2 ICAM1 MMP9 PLAT SELL SELP
8 neoplasm MP:0002006 9.43 ICAM1 MMP1 MMP9 SELL SERPINE1 TIMP1
9 respiratory system MP:0005388 9.17 F2 MMP9 PLAT SELL SELP SERPINE1

Drugs & Therapeutics for Venous Insufficiency

Drugs for Venous Insufficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 128)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hesperidin Approved, Investigational Phase 4,Phase 3 520-26-3 53477767
2
Polidocanol Approved Phase 4,Phase 3 9002-92-0
3
Sodium Tetradecyl Sulfate Approved, Investigational Phase 4,Phase 2,Not Applicable 1191-50-0, 139-88-8 5248 14492
4
Glucosamine Approved, Investigational Phase 4,Early Phase 1 3416-24-8 439213
5
Racepinephrine Approved Phase 4 329-65-7 838
6
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
7
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
8
Rivaroxaban Approved Phase 4,Not Applicable 366789-02-8
9
Serine Approved, Nutraceutical Phase 4,Not Applicable 56-45-1 5951
10
Troxerutin Investigational Phase 4,Not Applicable 7085-55-4 5486699
11
Coumarin Experimental Phase 4 91-64-5 323
12 Anesthetics Phase 4,Not Applicable
13 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
14 Anesthetics, Local Phase 4,Not Applicable
15 Anticoagulants Phase 4,Phase 3,Phase 2,Not Applicable
16 Heparinoids Phase 4
17 Salicylates Phase 4,Phase 1,Phase 2
18 Aminaftone Phase 4
19 Coagulants Phase 4,Phase 3,Not Applicable
20 Hemostatics Phase 4,Phase 3,Not Applicable
21 Anti-Inflammatory Agents Phase 4,Not Applicable
22 Fibrinolytic Agents Phase 4,Phase 3,Not Applicable
23 Anti-Asthmatic Agents Phase 4
24 Neurotransmitter Agents Phase 4
25 Adrenergic beta-Agonists Phase 4
26 Anti-Arrhythmia Agents Phase 4
27 Adrenergic Agents Phase 4
28 Diuretics, Potassium Sparing Phase 4
29 Epinephryl borate Phase 4
30 Mydriatics Phase 4
31 Adrenergic alpha-Agonists Phase 4
32 Sympathomimetics Phase 4
33 Adrenergic Agonists Phase 4
34 Peripheral Nervous System Agents Phase 4
35 Sodium Channel Blockers Phase 4
36 Respiratory System Agents Phase 4
37 Central Nervous System Depressants Phase 4,Not Applicable
38 Autonomic Agents Phase 4
39 Bronchodilator Agents Phase 4
40 Vasoconstrictor Agents Phase 4
41 Serine Proteinase Inhibitors Phase 4,Not Applicable
42 Antithrombin III Phase 4,Not Applicable
43 HIV Protease Inhibitors Phase 4,Not Applicable
44 Antithrombins Phase 4,Not Applicable
45 Factor Xa Inhibitors Phase 4,Not Applicable
46
protease inhibitors Phase 4,Not Applicable
47 Glucuronyl glucosamine glycan sulfate Phase 4
48 Hypoglycemic Agents Phase 4
49 Lipid Regulating Agents Phase 4
50 Hypolipidemic Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 231)
# Name Status NCT ID Phase Drugs
1 Clinical Non-inferiority Study Between Diosmin 600mg & Diosmin + Hesperidin in Symptomatic Chronic Venous Insufficiency Completed NCT03471910 Phase 4 Diosmin;Diosmin / Hesperidin
2 Efficacy and Safety of the Use of Venocur Triplex® in Patients With Chronic Venous Insufficiency Completed NCT00835822 Phase 4 Venocur Triplex®;placebo
3 Tolerability of Antistax® in Patients Suffering From Chronic Venous Insufficiency (CVI) Completed NCT02184234 Phase 4 Antistax film coated tablets
4 Efficacy and Safety of Coumarin and Troxerutin in the Symptomatic Treatment of Chronic Venous Insufficiency Completed NCT01848210 Phase 4 Coumarin/troxerutin;Placebo
5 Efficacy and Safety of Esarin Gel in Chronic Venous Insufficiency and Varicose Veins Completed NCT02346058 Phase 4 Esarin Gel
6 Iliac Vein Stenting in Advanced Chronic Venous Insufficiency Completed NCT02149212 Phase 4 Phlebotonic
7 Practicability of Gliding Aids for Medical Compression Stockings Completed NCT01432795 Phase 4
8 Radiofrequency Ablation vs Laser Ablation of the Incompetent Greater Saphenous Vein Completed NCT02236338 Phase 4
9 Radiofrequency Ablation vs. Laser Ablation of the Incompetent Small Saphenous Vein Completed NCT02248740 Phase 4
10 Neuromuscular Electrical Therapy in Venous Ulcers Completed NCT01372020 Phase 4
11 SocknLeg - a User Friendly Medical Compression Study of a Modified Application of a Medical Device Completed NCT02621632 Phase 4
12 The Fate Of Calf Perforators After Endovenous Laser Ablation Of Saphenous Veins Completed NCT01458795 Phase 4
13 A Pilot Trial of the Use of ReCell® Autologous Cell Harvesting Device for Venous Leg Ulcers Completed NCT01743053 Phase 4
14 Polidocanol Versus Glucose Treatment of Telangiectasia Trial Completed NCT02657252 Phase 4 Glucose;Polidocanol with Glucose
15 Study Protocol Comparing Polidocanol Versus Hypertonic Glucose for Treatment of Reticular Veins Completed NCT02054325 Phase 4 Polidocanol with Glucose;Glucose
16 ClosureFAST vs. Laser Ablation for the Treatment of GSV Disease: A Multicenter, Single-Blinded, Randomized Study. Completed NCT00509392 Phase 4
17 Laser Ablation Versus Mechanochemical Ablation Trial Recruiting NCT02627846 Phase 4 Lidocaine with 1:200,000 epinephrine solution;Lidocaine with 1:200,000 epinephrine solution;Sodium Bicarbonate;Sodium Tetradecyl Sulphate
18 Study of Foam Sclerotherapy Versus Ambulatory Phlebectomy Recruiting NCT03416413 Phase 4 Foam sclerotherapy
19 Rivaroxaban With Diosmine in Long-term Treatment of DVT Active, not recruiting NCT03413618 Phase 4 Rivaroxaban;Diosmin
20 Study of Antiinflammatory Effects of Detralex (Daflon) Enrolling by invitation NCT01654016 Phase 4 Detralex
21 Prospective Evaluation of the QoL of Patients With PTS Who Receive Compression Therapy and Sulodexide Terminated NCT02512601 Phase 4 Sulodexide
22 RCT Comparing Standard Cannula Delivered FS, UGFS and ClariVein® in the Management of SVI Withdrawn NCT02010437 Phase 4 Sodium Tetradecyl Sulphate (STS)
23 Study to Evaluate the Efficacy and Tolerability of Venaflon Use in Reducing the Symptoms Caused by Chronic Venous Insufficiency When Compared With Daflon Unknown status NCT01477281 Phase 3 Daflon;Venaflon (Diosmin and Hesperidin)
24 Study to Assess the Efficacy and Safety of Endolex Forte VErsus Diosmin and Hesperidin in Reducing VeNous Insufficiency Unknown status NCT02927483 Phase 3
25 Efficacy and Tolerability of the Use of Varicell Compared With Daflon Unknown status NCT01321619 Phase 3 Daflon;Varicell placebo
26 Comparative Efficacy of Two Preparations of the Association Diosmin (450 mg) + Hesperidin (50 mg) in the Treatment of Chronic Venous Insufficiency (CVI) Unknown status NCT01110512 Phase 3 Flavonid;Daflon
27 Safety and Efficacy Study of ICXP007 With Compression Bandaging for the Treatment of Non-Infected Venous Leg Ulcers Unknown status NCT00232973 Phase 3 ICXP007
28 Treatment Trial for Post-Thrombotic Syndrome Unknown status NCT00633971 Phase 3
29 Efficacy and Tolerability of Antistax® in Male and Female Patients Suffering From Chronic Venous Insufficiency Completed NCT02191254 Phase 3 Antistax®;Placebo
30 Assess the Efficacy and Tolerability of Antistax Film-coated Tablets in Patients With Chronic Venous Insufficiency Completed NCT00855179 Phase 3 Red vine leaf extract (AS 195);Placebo
31 Crenobalneotherapy in the Treatment of Chronic Venous Insufficiency Completed NCT01956318 Phase 3
32 Efficacy and Tolerability CVI (A 12-week, Double-blind, Randomised, Placebo-controlled, Multicentre Trial (CVI) Completed NCT00292435 Phase 3 Read vine leaf extract (AS 195)
33 The Influence of Compression Stockings on Skin's Barrier Function at Patients With Chronic Venous Disease Completed NCT00196443 Phase 2, Phase 3
34 THERMES ET VEINES: Spa for Prevention of Leg Ulcers Completed NCT00838500 Phase 3 Immediate spa treatment;Late spa treatment
35 Efficacy on Volume Reduction and Tolerance of Progressiv' Medical Compressive Therapy (MCT) V0322 BC in Patients With Chronic Venous Oedema Completed NCT01402921 Phase 3
36 Clinical Study of BNS003 on Swelling in Legs Due to Venous Reflux Completed NCT02211898 Phase 3 BNS003
37 ESGVS: Sclerotherapy With Lauromacrogol Completed NCT00348764 Phase 3 lauromacrogol
38 Evaluation of Long-Term Sequelae After Thrombophlebitis, i.e. Deep Venous Thrombosis of the Lower Extremities Completed NCT00628576 Phase 3 unfractionated heparin;Tinzaparin (Leo)
39 Polidocanol Endovenous Microfoam (PEM) Versus Vehicle for the Treatment of Saphenofemoral Junction (SFJ) Incompetence Completed NCT01231373 Phase 3 polidocanol injectable foam, 0.125%;polidocanol injectable foam, 0.5%;polidocanol injectable foam, 1.0%;Vehicle
40 Efficacy and Safety Study of Polidocanol Injectable Foam for the Treatment of Saphenofemoral Junction (SFJ) Incompetence Completed NCT01072877 Phase 3 Polidocanol injectable foam (PEM);Placebo Vehicle
41 Study Investigating the Safety and Efficacy of HP802-247 in the Treatment of Venous Leg Ulcers >12 cm2 to ≤ 36 cm2 Completed NCT01737762 Phase 3
42 Acute Venous Thrombosis: Thrombus Removal With Adjunctive Catheter-Directed Thrombolysis Completed NCT00790335 Phase 3 Recombinant tissue plasminogen activator (rt-PA)
43 Full-Leg vs Below-Knee Elastic Stockings for Prevention of the Post-Thrombotic Syndrome Completed NCT00426075 Phase 3
44 The SOX Trial: Compression Stockings to Prevent the Post-Thrombotic Syndrome Completed NCT00143598 Phase 3
45 Evaluation of a Venous-Return Assist Device (Venowave) to Treat Post-Thrombotic Syndrome: A Randomized Controlled Trial Completed NCT00182208 Phase 3
46 PRP ULCERAS: Clinical Trial Phase III Active, not recruiting NCT02213952 Phase 3 Platelet-Rich Plasma
47 EVENT: Hydrotherapy and Deep Venous Thrombosis Terminated NCT00348907 Phase 3 thermal cure;late thermal cure
48 Safety and Efficacy Trial of HP802-247 in the Treatment of Chronic Venous Leg Ulcers Terminated NCT01853384 Phase 3
49 Clinical Effectiveness of Topical Autologous Platelet Gel for the Treatment of Venous Ulcers Withdrawn NCT00273234 Phase 3
50 Pediatric High-Risk Deep Venous Thrombosis Lytic Outcomes Trial Withdrawn NCT02767232 Phase 3 Recombinant tissue plasminogen activator (rt-PA);Standard Anticoagulation Therapy

Search NIH Clinical Center for Venous Insufficiency

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: venous insufficiency

Genetic Tests for Venous Insufficiency

Genetic tests related to Venous Insufficiency:

# Genetic test Affiliating Genes
1 Venous Insufficiency 29

Anatomical Context for Venous Insufficiency

MalaCards organs/tissues related to Venous Insufficiency:

41
Skin, Testes, Bone, Endothelial, Brain, Heart, Lymph Node

Publications for Venous Insufficiency

Articles related to Venous Insufficiency:

(show top 50) (show all 1097)
# Title Authors Year
1
Retrograde administration of ultrasound-guided endovenous microfoam chemical ablation for the treatment of superficial venous insufficiency. ( 29909854 )
2018
2
Experience of Using Shear Wave Elastography Imaging in Superficial Venous Insufficiency of the Lower Extremity. ( 29634667 )
2018
3
Thermal and Nonthermal Endovenous Ablation Options for Treatment of Superficial Venous Insufficiency. ( 29502779 )
2018
4
The influence of exercise on ulcer healing in patients with chronic venous insufficiency. ( 29368880 )
2018
5
A retrospective study of a new n-butyl-2-cyanoacrylate glue ablation catheter incorporated with application guiding light for the treatment of venous insufficiency: Twelve-month results. ( 29642798 )
2018
6
Systematic review and meta-analysis of endovascular and surgical revascularization for patients with chronic lower extremity venous insufficiency and varicose veins. ( 29421005 )
2018
7
Chronic Cerebro-Spinal Venous Insufficiency in Multiple Sclerosis: Is It the End? ( 29629362 )
2018
8
Endovenous Thermal Ablation of Recurrent Varicose Veins due to Residual Great Saphenous Venous Insufficiency After Saphenous Venous Surgery: A Comparative Study. ( 29781902 )
2018
9
Varicose Veins and Lower Extremity Venous Insufficiency. ( 29628617 )
2018
10
US budget impact of increased payer adoption of the Flexitouch advanced pneumatic compression device in lymphedema patients with advanced chronic venous insufficiency and multiple infections. ( 29975564 )
2018
11
Plasma concentration of selected biochemical markers of endothelial dysfunction in women with various severity of chronic venous insufficiency (CVI)-A pilot study. ( 29377939 )
2018
12
Efficacy of subcutaneous lidocaine injection in venous insufficiency: a prospective, randomized, controlled study, and new treatment protocol. ( 29950758 )
2018
13
Iliac vein stenosis is an underdiagnosed cause of pelvic venous insufficiency. ( 29292119 )
2018
14
Suppressed networks of inflammatory mediators characterize chronic venous insufficiency. ( 29439934 )
2018
15
Venous insufficiency: Differences in the content of trace elements. A preliminary report. ( 29616754 )
2018
16
Chronic cerebrospinal venous insufficiency, chlamydia and multiple sclerosis. ( 30200825 )
2018
17
Response to "Chronic cerebrospinal venous insufficiency, chlamydia and multiple sclerosis": CCSVI, Chlamydia pneumoniae and multiple sclerosis clarification. ( 30217137 )
2018
18
Frequency and Significance of Perforating Venous Insufficiency in Patients with Chronic Venous Insufficiency of Lower Extremity. ( 30002576 )
2018
19
Implication of the PI3K/Akt/mTOR Pathway in the Process of Incompetent Valves in Patients with Chronic Venous Insufficiency and the Relationship with Aging. ( 30057669 )
2018
20
Chronic venous insufficiency: a new concept to understand pathophysiology at the microvascular level - a pilot study. ( 30067139 )
2018
21
Correlation of obesity & comorbid conditions with chronic venous insufficiency: Results of a single-centre study. ( 30082571 )
2018
22
Validation of a Gravitational Model to Study Local Endogenous Biomarkers in Chronic Venous Insufficiency. ( 30181065 )
2018
23
Influence of Diosmin Treatment on the Level of Oxidative Stress Markers in Patients with Chronic Venous Insufficiency. ( 30228853 )
2018
24
Chronic venous insufficiency and varicose veins of the lower extremities. ( 30360023 )
2018
25
Acroangiodermatitis of Mali (Pseudo-Kaposi Sarcoma) Associated with Chronic Venous Insufficiency and Obesity: A Case Report. ( 30457563 )
2018
26
An Osteopathic Approach to Stasis Dermatitis and Chronic Venous Insufficiency. ( 30476998 )
2018
27
Duplex ultrasound findings and clinical classification of lower extremity chronic venous insufficiency in a Thai population. ( 30477978 )
2018
28
Dystrophic Calcifications in Chronic Venous Insufficiency. ( 30551796 )
2018
29
Impact of copper compression stockings on venous insufficiency and lipodermatosclerosis: A randomised controlled trial. ( 30149775 )
2018
30
A case of lipomembranous panniculitis with a dramatic response to the treatment of venous insufficiency. ( 29991978 )
2018
31
Placentas from women with pregnancy-associated venous insufficiency show villi damage with evidence of hypoxic cellular stress. ( 29626597 )
2018
32
Carboxytherapy: Controls the inflammation and enhances the production of fibronectin on wound healing under venous insufficiency. ( 30467979 )
2018
33
Noninvasive vascular occlusion with HIFU for venous insufficiency treatment: preclinical feasibility experience in rabbits. ( 30523945 )
2018
34
Ultrasound-guided foam sclerotherapy for severe chronic venous insufficiency. ( 29019582 )
2017
35
Case of chronic venous insufficiency-associated Kaposi's sarcoma in a Japanese patient. ( 28771851 )
2017
36
Genetic predisposition for chronic venous insufficiency in several genes for matrix metalloproteinases (MMP-2, MMP-9, MMP-12) and their inhibitor TIMP-2. ( 28662285 )
2017
37
Increased inflammatory status in chronic venous insufficiency patients. ( 28592220 )
2017
38
Advanced Chronic Venous Insufficiency. ( 28024458 )
2017
39
Quantification of early cutaneous manifestations of chronic venous insufficiency by automated analysis of photographic images: Feasibility and technical considerations. ( 28403688 )
2017
40
Changing Medicare Utilization of Minimally Invasive Procedures for the Treatment of Chronic Venous Insufficiency. ( 28396193 )
2017
41
Chronic Venous Insufficiency: a Frequently Underdiagnosed and Undertreated Pathology. ( 28878840 )
2017
42
A failure of preoperative duplex imaging to diagnose a lower extremity venous aneurysm in a patient with severe chronic venous insufficiency. ( 28255445 )
2017
43
Treatment of incompetent perforators in recurrent venous insufficiency with adhesive embolization and sclerotherapy. ( 28956508 )
2017
44
TGF-I^1 in Vascular Wall Pathology: Unraveling Chronic Venous Insufficiency Pathophysiology. ( 29186866 )
2017
45
A Systematic Review and Meta-analysis of Exercise Intervention for the Treatment of Calf Muscle Pump Impairment in Individuals with Chronic Venous Insufficiency. ( 28873064 )
2017
46
Venous ultrasonography findings and clinical correlations in 104 Thai patients with chronic venous insufficiency of the legs. ( 28503700 )
2017
47
Chronic venous insufficiency - a review of pathophysiology, diagnosis, and treatment. ( 28485865 )
2017
48
Remodelling of collagen fibres in the placentas of women with venous insufficiency during pregnancy. ( 29171654 )
2017
49
Differentiation of functional venous insufficiency and leg lymphedema complicated by functional venous insufficiency using subcutaneous tissue ultrasonography. ( 27987622 )
2017
50
Efficiency of a New Combined Laser Therapy in Patients With Trophic Ulcers of Lower Extremities and Chronic Venous Insufficiency. ( 29123633 )
2017

Variations for Venous Insufficiency

Expression for Venous Insufficiency

Search GEO for disease gene expression data for Venous Insufficiency.

Pathways for Venous Insufficiency

Pathways related to Venous Insufficiency according to GeneCards Suite gene sharing:

(show all 36)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.87 CRP ICAM1 ITGA4 MMP1 MMP9 SELL
2
Show member pathways
13.27 F2 ICAM1 ITGA4 MMP1 MMP9 SERPINE1
3
Show member pathways
13.21 ICAM1 MMP1 MMP9 TIMP1 VCAM1 VWF
4
Show member pathways
12.69 F2 ITGA4 MMP1 PLAT SELL SELP
5
Show member pathways
12.53 ICAM1 ITGA4 MMP9 VCAM1
6
Show member pathways
12.46 ICAM1 ITGA4 MMP1 MMP9 SERPINE1 TIMP1
7
Show member pathways
12.23 CRP F2 ICAM1 PLAT SERPINE1
8
Show member pathways
12.11 F2 ITGA4 MMP1 SELL SELP
9
Show member pathways
12.09 F2 ICAM1 ITGA4 MMP1 MMP9 VCAM1
10
Show member pathways
12.08 F2 PLAT SERPINE1 VWF
11
Show member pathways
12.03 ICAM1 ITGA4 VCAM1 VWF
12 11.99 F2 PLAT SERPINE1 VWF
13 11.98 ICAM1 MMP9 PLAT VCAM1
14 11.96 ICAM1 ITGA4 SELL VCAM1
15 11.96 ICAM1 ITGA4 SELL SELP VCAM1
16
Show member pathways
11.93 F2 MMP9 PLAT
17 11.9 ICAM1 MMP9 SELP
18 11.86 ICAM1 MMP9 VCAM1
19 11.86 ICAM1 ITGA4 MMP9 SERPINE1 VCAM1
20 11.79 ICAM1 SERPINE1 VCAM1
21
Show member pathways
11.78 MMP1 MMP9 TIMP1
22 11.78 ICAM1 MMP1 MMP9 TIMP1 VCAM1
23 11.73 MMP9 TIMP1 VWF
24
Show member pathways
11.58 ICAM1 MMP1 MMP9 VCAM1
25 11.46 ICAM1 SELP VCAM1
26 11.42 ICAM1 MMP9 PLAT SELP
27 11.4 ICAM1 ITGA4 VCAM1
28 11.33 MMP1 MMP9 SELL
29 11.03 MMP9 PLAT
30 10.99 F2 MMP1
31 10.94 MMP1 TIMP1
32 10.89 MMP1 MMP9
33 10.85 ICAM1 VCAM1
34 10.85 F2 ICAM1 MMP9 TIMP1
35 10.81 MMP1 MMP9 PLAT SERPINE1 TIMP1
36 10.75 PLAT SERPINE1

GO Terms for Venous Insufficiency

Cellular components related to Venous Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.92 CRP F2 MMP1 MMP9 PLAT SERPINE1
2 cell surface GO:0009986 9.8 ICAM1 ITGA4 PLAT SELL VCAM1
3 extracellular matrix GO:0031012 9.73 MMP1 MMP9 TIMP1 VWF
4 external side of plasma membrane GO:0009897 9.65 F2 ICAM1 SELL SELP VCAM1
5 extracellular exosome GO:0070062 9.61 F2 ICAM1 ITGA4 MMP9 PLAT SERPINE1
6 collagen-containing extracellular matrix GO:0062023 9.55 ICAM1 MMP9 PLAT SERPINE1 VWF
7 platelet alpha granule lumen GO:0031093 9.54 SERPINE1 TIMP1 VWF
8 extracellular space GO:0005615 9.28 CRP F2 ICAM1 MMP9 PLAT SELP

Biological processes related to Venous Insufficiency according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.88 ICAM1 ITGA4 SELL SELP VCAM1 VWF
2 regulation of immune response GO:0050776 9.8 ICAM1 ITGA4 SELL VCAM1
3 response to hypoxia GO:0001666 9.77 ICAM1 PLAT VCAM1
4 cytokine-mediated signaling pathway GO:0019221 9.77 ICAM1 MMP1 MMP9 TIMP1 VCAM1
5 response to lipopolysaccharide GO:0032496 9.76 ICAM1 SELP VCAM1
6 platelet degranulation GO:0002576 9.73 SELP SERPINE1 TIMP1 VWF
7 extracellular matrix disassembly GO:0022617 9.69 MMP1 MMP9 TIMP1
8 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.63 ICAM1 SELP VCAM1
9 extracellular matrix organization GO:0030198 9.63 ICAM1 ITGA4 MMP9 SERPINE1 VCAM1 VWF
10 negative regulation of proteolysis GO:0045861 9.58 F2 PLAT
11 calcium-mediated signaling using intracellular calcium source GO:0035584 9.57 SELP VCAM1
12 blood coagulation, intrinsic pathway GO:0007597 9.56 F2 VWF
13 leukocyte cell-cell adhesion GO:0007159 9.56 ICAM1 ITGA4 SELP VCAM1
14 positive regulation of blood coagulation GO:0030194 9.55 F2 SERPINE1
15 positive regulation of leukocyte migration GO:0002687 9.54 ITGA4 SELP
16 negative regulation of fibrinolysis GO:0051918 9.52 F2 SERPINE1
17 fibrinolysis GO:0042730 9.5 F2 PLAT SERPINE1
18 membrane to membrane docking GO:0022614 9.48 ICAM1 VCAM1
19 leukocyte migration GO:0050900 9.43 ICAM1 ITGA4 MMP1 MMP9 SELL SELP
20 leukocyte tethering or rolling GO:0050901 8.92 ITGA4 SELL SELP VCAM1

Molecular functions related to Venous Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 9.58 F2 SELL SELP
2 serine-type endopeptidase activity GO:0004252 9.56 F2 MMP1 MMP9 PLAT
3 integrin binding GO:0005178 9.54 ICAM1 VCAM1 VWF
4 cell adhesion molecule binding GO:0050839 9.33 ITGA4 SELL VCAM1
5 oligosaccharide binding GO:0070492 9.32 SELL SELP
6 glycosphingolipid binding GO:0043208 8.96 SELL SELP
7 protease binding GO:0002020 8.92 SELL SERPINE1 TIMP1 VWF

Sources for Venous Insufficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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