MCID: VNS003
MIFTS: 54

Venous Insufficiency

Categories: Blood diseases, Cardiovascular diseases

Aliases & Classifications for Venous Insufficiency

MalaCards integrated aliases for Venous Insufficiency:

Name: Venous Insufficiency 12 29 44 15 70 32
Peripheral Venous Insufficiency 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10128
ICD9CM 34 459.81
MeSH 44 D014689
NCIt 50 C127822
SNOMED-CT 67 20696009
ICD10 32 I87.2
UMLS 70 C0042485

Summaries for Venous Insufficiency

Disease Ontology : 12 A vein disease that is characterized by impaired flow of blood through the veins.

MalaCards based summary : Venous Insufficiency, also known as peripheral venous insufficiency, is related to lipodermatosclerosis and post-thrombotic syndrome. An important gene associated with Venous Insufficiency is F2 (Coagulation Factor II, Thrombin), and among its related pathways/superpathways are Innate Immune System and Integrin Pathway. The drugs Hesperidin and Epinephrine have been mentioned in the context of this disorder. Affiliated tissues include skin, endothelial and brain, and related phenotypes are cardiovascular system and homeostasis/metabolism

Related Diseases for Venous Insufficiency

Diseases in the Venous Insufficiency family:

Chronic Venous Insufficiency

Diseases related to Venous Insufficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 526)
# Related Disease Score Top Affiliating Genes
1 lipodermatosclerosis 31.9 VEGFA PLAT MMP1
2 post-thrombotic syndrome 31.0 VCAM1 SERPINE1 ICAM1 F5 F2
3 telangiectasis 30.7 VEGFA NDP ELN
4 relapsing-remitting multiple sclerosis 30.2 TIMP1 MMP9 ITGA4 ICAM1
5 hemorrhoid 30.1 MMP9 F2 CRP
6 chronic venous insufficiency 30.1 VEGFA VCAM1 TIMP1 SERPINE1 SELP SELL
7 chronic ulcer of skin 29.9 VEGFA MMP9 MMP1 CRP
8 papilledema 29.9 VEGFA F2 CRP
9 infective endocarditis 29.9 SERPINE1 F2 CRP
10 exanthem 29.8 VEGFA F2 CRP
11 retinal vascular disease 29.8 VEGFA NDP MTHFR ICAM1
12 purpura 29.8 VWF F2 CRP
13 portal hypertension 29.8 VWF VEGFA F2 ELN
14 sickle cell disease 29.7 VWF VCAM1 SELP SELL
15 arteriosclerosis obliterans 29.7 VCAM1 SELP ICAM1
16 thrombophlebitis 29.7 VWF SERPINE1 PLAT MTHFR F5 F2
17 arachnoiditis 29.7 IL1A CRP
18 microvascular complications of diabetes 5 29.6 VEGFA VCAM1 SERPINE1 ICAM1
19 thrombophilia due to thrombin defect 29.6 VWF SERPINE1 PLAT MTHFR F5 F2
20 intracranial hypertension 29.6 SERPINE1 MTHFR F5 F2
21 sleep apnea 29.6 VEGFA VCAM1 SERPINE1 ICAM1 CRP
22 contact dermatitis 29.5 VCAM1 SELL IL1A ICAM1
23 sudden sensorineural hearing loss 29.5 MTHFR F5 F2
24 brain edema 29.5 VEGFA PLAT MMP9 CRP
25 arteries, anomalies of 29.5 VEGFA VCAM1 SERPINE1 ICAM1 CRP
26 buerger disease 29.5 VEGFA VCAM1 ICAM1 CRP
27 hemangioma 29.5 VWF VEGFA MMP9 F2
28 atrial fibrillation 29.4 VWF SELP PLAT F2 CRP
29 pyoderma 29.4 MMP9 MMP1 CRP
30 peripheral artery disease 29.3 VWF VEGFA VCAM1 SELP ICAM1 CRP
31 thrombosis 29.3 VWF SERPINE1 SELP PLAU PLAT MTHFR
32 body mass index quantitative trait locus 11 29.3 VEGFA VCAM1 SERPINE1 SELL ICAM1 CRP
33 tetralogy of fallot 29.3 VEGFA MTHFR MMP9 ELN CRP
34 retinal vein occlusion 29.2 VEGFA SERPINE1 MTHFR F5 F2
35 intermittent claudication 29.2 VWF VEGFA SERPINE1 SELP F2 CRP
36 amaurosis fugax 29.2 SERPINE1 MTHFR MMP9 F5
37 primary progressive multiple sclerosis 29.2 VCAM1 TIMP1 SELL MMP9 ITGA4 ICAM1
38 thrombophilia 29.2 VWF SERPINE1 SELP PLAT MTHFR F5
39 pulmonary embolism 29.2 VWF SERPINE1 PLAU PLAT MTHFR F5
40 varicose veins 29.1 VWF VEGFA TIMP1 PLAT MTHFR MMP9
41 osteoarthritis 29.1 TIMP1 MMP9 MMP1 IL1A CRP
42 vasculitis 29.1 VWF VCAM1 SELP SELL ITGA4 ICAM1
43 skin disease 29.1 VEGFA SELL MMP1 IL1A ICAM1 ELN
44 pulmonary disease, chronic obstructive 29.0 TIMP1 MMP9 MMP1 ELN CRP
45 endocarditis 29.0 VCAM1 SERPINE1 PLAT IL1A F2 CRP
46 hydronephrosis 29.0 VWF VEGFA TIMP1 MMP9 ICAM1 CRP
47 central retinal vein occlusion 28.9 VWF VEGFA PLAT MTHFR F5 F2
48 deficiency anemia 28.9 TIMP1 SELP F5 F2 CRP
49 pulmonary hypertension 28.9 VWF VEGFA TIMP1 SERPINE1 SELP PLAT
50 homocysteinemia 28.6 VWF VCAM1 SERPINE1 MTHFR F5 F2

Comorbidity relations with Venous Insufficiency via Phenotypic Disease Network (PDN): (show all 21)


Acute Cystitis Aortic Valve Disease 1
Bronchitis Chronic Kidney Disease
Chronic Pulmonary Heart Disease Decubitus Ulcer
Deficiency Anemia Familial Atrial Fibrillation
Femoral Vein Thrombophlebitis Generalized Atherosclerosis
Heart Disease Hypertension, Essential
Hypothyroidism Iron Deficiency Anemia
Mitral Valve Disease Osteoporosis
Peripheral Vascular Disease Post-Thrombotic Syndrome
Protein-Energy Malnutrition Schizophreniform Disorder
Tinea Pedis

Graphical network of the top 20 diseases related to Venous Insufficiency:



Diseases related to Venous Insufficiency

Symptoms & Phenotypes for Venous Insufficiency

MGI Mouse Phenotypes related to Venous Insufficiency:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.42 CRP F2 F5 ICAM1 IL1A ITGA4
2 homeostasis/metabolism MP:0005376 10.36 CRP F2 F5 ICAM1 IL1A MMP1
3 immune system MP:0005387 10.31 CRP F2 ICAM1 IL1A ITGA4 MMP1
4 growth/size/body region MP:0005378 10.29 F2 F5 ICAM1 MMP9 MTHFR PLAT
5 hematopoietic system MP:0005397 10.27 ICAM1 IL1A ITGA4 MMP9 PLAT PLAU
6 mortality/aging MP:0010768 10.2 F2 F5 ICAM1 ITGA4 MMP9 MTHFR
7 integument MP:0010771 10.15 F2 F5 ICAM1 IL1A MMP9 MTHFR
8 neoplasm MP:0002006 9.91 ICAM1 IL1A MMP1 MMP9 PLAU SELL
9 reproductive system MP:0005389 9.85 F2 MMP9 MTHFR NDP PLAT PLAU
10 respiratory system MP:0005388 9.61 F2 MMP9 PLAT PLAU SELL SELP
11 skeleton MP:0005390 9.32 F2 MMP9 MTHFR NDP PLAT PLAU

Drugs & Therapeutics for Venous Insufficiency

Drugs for Venous Insufficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 76)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hesperidin Approved, Investigational Phase 4 520-26-3 53477767
2
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
3
Racepinephrine Approved Phase 4 329-65-7 838
4
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
5
Coumarin Experimental Phase 4 91-64-5 323
6
Troxerutin Investigational Phase 4 7085-55-4 5486699
7 Anticoagulants Phase 4
8 Hemostatics Phase 4
9 Salicylates Phase 4
10 Heparinoids Phase 4
11 Coagulants Phase 4
12 Aminaftone Phase 4
13 Adrenergic alpha-Agonists Phase 4
14 Vasoconstrictor Agents Phase 4
15 Adrenergic beta-Agonists Phase 4
16 Respiratory System Agents Phase 4
17 Anti-Asthmatic Agents Phase 4
18 Epinephryl borate Phase 4
19 Sympathomimetics Phase 4
20 Adrenergic Agents Phase 4
21 Mydriatics Phase 4
22 Neurotransmitter Agents Phase 4
23 Adrenergic Agonists Phase 4
24 Bronchodilator Agents Phase 4
25 Anesthetics, Local Phase 4
26 Sodium Channel Blockers Phase 4
27 Anti-Arrhythmia Agents Phase 4
28 Diuretics, Potassium Sparing Phase 4
29
Polidocanol Approved Phase 3 9002-92-0
30
carbamide peroxide Approved Phase 2, Phase 3 124-43-6
31
Thrombin Approved, Investigational Phase 3
32 Tin Fluorides Phase 3
33 Grape Approved Phase 2
34
Methyl salicylate Approved, Vet_approved Phase 1, Phase 2 119-36-8 4133
35
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 2 65-23-6 1054
36
Horse chestnut Experimental Phase 2
37
Quercetin Experimental, Investigational Phase 2 117-39-5 5280343
38 Vitamin B Complex Phase 2
39 Vitamin B 6 Phase 2
40 Protective Agents Phase 2
41 Antioxidants Phase 2
42 Antirheumatic Agents Phase 1, Phase 2
43
Pyridoxal Experimental, Nutraceutical Phase 2 66-72-8 1050
44
Silicon Approved, Investigational 7440-21-3 4082203
45
Ticlopidine Approved 55142-85-3 5472
46
Pentoxifylline Approved, Investigational 6493-05-6 4740
47
Aspirin Approved, Vet_approved 50-78-2 2244
48
Chlorhexidine Approved, Vet_approved 55-56-1 2713 9552079
49
Nimesulide Approved, Investigational, Withdrawn 51803-78-2 4495
50
Copper Approved, Investigational 7440-50-8 27099

Interventional clinical trials:

(show top 50) (show all 173)
# Name Status NCT ID Phase Drugs
1 The Fate Of Calf Perforators After Endovenous Laser Ablation Of Saphenous Veins Completed NCT01458795 Phase 4
2 Evaluation of Efficacy and Safety of the Fixed-dose Combination of Coumarin and Troxerutin (Venalot®) Versus Placebo in the Symptomatic Treatment of Chronic Venous Insufficiency - VENACT Completed NCT01848210 Phase 4 Coumarin/troxerutin;Placebo
3 Evaluate the Efficacy and Safety of Esarin Gel in the Treatment of Chronic Venous Insufficiency or Varicose Vein Combine With Superficial Vein Thrombophlebitis in Outpatient Completed NCT02346058 Phase 4 Esarin Gel
4 Gliding Aids for Medical Compression Stockings - Practicability in Elderly Patients With Chronic Venous Insufficiency Completed NCT01432795 Phase 4
5 Radiofrequency Ablation vs Laser Ablation of the Incompetent Greater Saphenous Vein: A Prospective Randomized Trial Completed NCT02236338 Phase 4
6 Multicenter, Prospective, Randomized, Double-Blind Study to Assess the Therapeutic Efficacy and Safety of the Use of Venocur Triplex® in Patients With Chronic Venous Insufficiency Completed NCT00835822 Phase 4 Venocur Triplex®;placebo
7 Study of Antiinflammatory Effects of Detralex (Daflon) in Patients With Chronic Venous Disease Completed NCT01654016 Phase 4 Detralex
8 SocknLeg - a User Friendly Medical Compression Study of a Modified Application of a Medical Device Completed NCT02621632 Phase 4
9 The Effect of Neuromuscular Electrical Therapy on Pain in Patients With Venous Ulcers: a Controlled Clinical Trial Completed NCT01372020 Phase 4
10 Clinical Non-inferiority Study Between Diosmin 600 mg Tablets and Diosmin 900 mg + Hesperidin 100 mg Tablets in Symptomatic Chronic Venous Insufficiency After 6 Months of Treatment: Single-blind, Randomized, Parallel Group Study Completed NCT03471910 Phase 4 Diosmin;Diosmin / Hesperidin
11 A 6-week, Open, Multicentre Safety Trial to Evaluate the Tolerability Profile of Antistax® Film Coated Tablets (Extr. Vitis Viniferae Siccum), 360 mg/Day Per os, in Male and Female Patients Suffering From Chronic Venous Insufficiency Completed NCT02184234 Phase 4 Antistax film coated tablets
12 Randomized Double-blind Trial Between Clinical and Endovascular Treatment in Patients With Advanced Chronic Venous Insufficiency and Iliac Venous Obstruction Completed NCT02149212 Phase 4 Phlebotonic
13 A Randomised Clinical Trial Comparing Endovenous Laser Ablation and Mechanochemical Ablation (ClariVein®) in the Management of Superficial Venous Insufficiency Active, not recruiting NCT02627846 Phase 4 Lidocaine with 1:200,000 epinephrine solution;Lidocaine with 1:200,000 epinephrine solution;Sodium Bicarbonate;Sodium Tetradecyl Sulphate
14 Radiofrequency Ablation vs. Laser Ablation of the Incompetent Small Saphenous Vein: A Prospective Randomized Trial Terminated NCT02248740 Phase 4
15 A Randomised Clinical Trial Comparing Standard Cannula Delivered Foam Sclerotherapy, Catheter Directed Foam Sclerotherapy and ClariVein® Mechanochemical Ablation in the Management of Superficial Venous Insufficiency. Withdrawn NCT02010437 Phase 4 Sodium Tetradecyl Sulphate (STS)
16 A Clinical Multicenter, Phase III, Prospective, Randomized, Double-blind, Comparative Study to Evaluate the Efficacy and Tolerability of Venaflon Use in Reducing the Symptoms Caused by Chronic Venous Insufficiency When Compared With Daflon Unknown status NCT01477281 Phase 3 Daflon;Venaflon (Diosmin and Hesperidin)
17 Comparative Efficacy of Two Preparations of the Association Diosmin (450 mg) + Hesperidin (50 mg) in the Treatment of Chronic Venous Insufficiency (CVI) Unknown status NCT01110512 Phase 3 Flavonid;Daflon
18 Study Clinical, Multicenter,Phase III,Prospective,Randomized,Comparative Double Blind/Double-dummy to Assess the Efficacy and Tolerability of the Use of Varicell in Reducing the Symptoms Caused by Chronic Venous Insufficiency and Hemorrhoidal Syndrome When Compared With Daflon Unknown status NCT01321619 Phase 3 Daflon;Varicell placebo
19 A Comparative Study to Assess the Efficacy and Safety of Endolex Forte vs Diosmin and Hesperidin in Reducing the symptomatoLogy of Patients With ChronIc VeNous Insufficiency Between Functional Classes CEAP 1-4, During a Period of 6 Months Unknown status NCT02927483 Phase 3
20 A Prospective, Multi-Centre, Double Blind, Randomized, Placebo Controlled Trial to Evaluate the Safety and Efficacy of ICXP007 in a Phase III Trial With Four-Layer Therapeutic Compression, for the Treatment of Non-Infected Skin Leg Ulcers, Due to Venous-Insufficiency Unknown status NCT00232973 Phase 3 ICXP007
21 A Phase 3 Randomized, Double Blind, Vehicle Controlled Study Investigating the Safety and Efficacy of HP802-247 in the Treatment of Venous Leg Ulcers >12 cm2 to ≤ 36 cm2 Completed NCT01737762 Phase 3
22 Efficacy on Volume Reduction and Tolerance of Progressiv' Medical Compressive Therapy (MCT) V0322 BC in Patients With Chronic Venous Oedema. International, Multicentric, Randomised, Controlled, Double Blind Study, in Two Parallel Groups v0322 bc Versus Placebo Completed NCT01402921 Phase 3
23 Treatment of Greater Saphenous Vein (GSV) Insufficiency Using Echo-Guided Sclerotherapy With Lauromacrogol 400 Foam -Comparative Study of 3% Versus 1% Concentration. Completed NCT00348764 Phase 3 lauromacrogol
24 A 12-week, Double-blind, Randomised, Placebo-controlled, Multicentre Trial to Evaluate Efficacy and Tolerability of Antistax Film-coated Tablets, 360 mg/Day Orally, in Male and Female Patients Suffering From Chronic Venous Insufficiency. Completed NCT00292435 Phase 3 Read vine leaf extract (AS 195)
25 Prospective, Randomized and Explorative Controlled Study About Influences of Compression Stockings on Skin's Barrier Function at Patients With Chronic Venous Insufficiency Completed NCT00196443 Phase 2, Phase 3
26 A 12-week, Double-blind, Randomised, Placebo-controlled, Multicentre Trial to Evaluate Efficacy and Tolerability of Antistax® Film Coated Tablets, 360 mg/Day Orally, in Male and Female Patients Suffering From Chronic Venous Insufficiency Completed NCT02191254 Phase 3 Antistax®;Placebo
27 Evaluation of the Efficacy of Spa Treatment for Prevention of Leg Ulcers in Advanced Chronic Venous Insufficiency. Completed NCT00838500 Phase 3 Immediate spa treatment;Late spa treatment
28 A 12-week, Double-blind, Randomised, Placebo-controlled, Multicentre Trial to Evaluate Efficacy and Tolerability of Antistax® Film Coated Tablets, 720 mg/Day Orally, in Male and Female Patients Suffering From Chronic Venous Insufficiency Completed NCT00855179 Phase 3 Red vine leaf extract (AS 195);Placebo
29 Clinical Study of BNS003 on Swelling Due to Disorder of Leg Venous Reflux Completed NCT02211898 Phase 3 BNS003
30 Crenobalneotherapy in the Treatment of Chronic Venous Insufficiency. A Randomized Clinical Trial. Completed NCT01956318 Phase 3
31 A Phase 3 Randomized Safety and Efficacy Trial of HP802-247 in the Treatment of Chronic Venous Leg Ulcers (EU) Terminated NCT01853384 Phase 3
32 Clinical Evaluation of the Safety and Effectiveness of Topical Autologous Platelet Gel (APG) for the Treatment of Lower Extremity Chronic Venous Insufficiency Ulcers. A Multicenter, Randomized, Controlled Clinical Trial Withdrawn NCT00273234 Phase 3
33 Endovenous Treatment of the Saphenous Vein With Biolitec 1470nm Laser Versus Vnus Closure Fast Unknown status NCT01972633 Phase 1, Phase 2
34 An Open-label, Non-randomized, Phase I/II Study of Allogeneic Human Umbilical Cord Tissue-Derived Mesenchymal Stem Cells (UC-MSC) and Liberation Therapy (When Associated With Chronic Cerebrovascular Venous Insufficiency) in Patients With Relapsing Remitting Multiple Sclerosis (RRMS) Unknown status NCT02587715 Phase 1, Phase 2
35 Endovascular Correction of Chronic Cerebrospinal Venous Insufficiency (CCSVI) and Evaluation of Influence of These Treatments on the Symptoms of Multiple Sclerosis Completed NCT01264848 Phase 1, Phase 2
36 A Randomized, Double-Blind, Placebo-Controlled, Dose-Response Study of the Safety and Efficacy of Thymosin Beta 4 in the Treatment of Patients With Venous Stasis Ulcers Completed NCT00832091 Phase 2 Thymosin Beta 4;Placebo
37 Assessment of Lymphatic Structure and Function Pre- and Post- Treatment and During Recovery in Head and Neck Cancer Patients Using NIR Fluorescence Lymphatic Imaging Completed NCT02946021 Phase 1, Phase 2 NIRFLI with ICG
38 The Efficacy of Red Vine Leaf Extract, Butcher's Broom, Horse Chestnut and Vitamin B6 on the Quality of Life in Females With Chronic Venous Insufficiency Completed NCT02498327 Phase 2
39 The Efficacy of Red Vine Leaf Extract, Butcher's Broom, Horse Chestnut and Vitamin B6 in the Treatment of Symptoms Associated With Chronic Venous Insufficiency Completed NCT02483962 Phase 2
40 Physical Conditioning in Management of Chronic Venous Insufficiency Completed NCT00013273 Phase 2
41 Evaluation of DermStream(tm) - an Irrigation Product for Chronic Wound Management Completed NCT00310752 Phase 1, Phase 2
42 The Ability of Antistax® to Improve Chronic Venous Insufficiency (CVI) I and II in Male and Female Patients: a Dose Response Study Completed NCT02191280 Phase 2 Antistax®, low dose;Antistax®, high dose;Placebo
43 A 17 Week, Randomised, Double-blind, Placebo Controlled Cross-over Trial to Evaluate the Efficacy of Antistax® Film Coated Tablets (Extr. Vitis Vinifera Siccum), 360 mg/Day p.o. in Improving Microcirculation of the Skin in the Leg of Male and Female Patients Suffering From Chronic Venous Insufficiency Completed NCT02191163 Phase 2 Antistax®;Placebo
44 A Phase II Randomized Study to Evaluate the Safety of the Compression Test Device Using Intermittent Pneumatic Compression Mode in Subjects With Venous Insufficiency and Oedema Completed NCT00732823 Phase 2
45 Phase I/II Interventional Clinical Trial of Balloon Venoplasty for Chronic Cerebrospinal Venous Insufficiency in Multiple Sclerosis Patients Completed NCT01864941 Phase 1, Phase 2
46 Preventing Venous Leg Ulcers With Cryotherapy: A Randomized Clinical Trial Completed NCT01509599 Phase 1, Phase 2
47 Monitoring and Managing Newly Healed Chronic Leg and Foot Ulcer Skin Temperature: A Cooling Intervention (MUSTCOOL) to Prevent Ulcer Recurrence Completed NCT02626156 Phase 2
48 A Phase 2, Randomized, Double-Blind, Vehicle-Controlled, Proof-of-Concept Study to Evaluate the Efficacy, Safety, and Local Tolerability of Crisaborole Ointment, 2%, in Adult Participants With Stasis Dermatitis Without Active Skin Ulceration Recruiting NCT04091087 Phase 2 crisaborole ointment
49 A Prospective, Randomized, Controlled, Multi-Center, Double Blind Study of ClariVein RES for Treatment of Venous Insufficiency Associated With Incompetent Saphenous Veins Due to Superficial Venous Reflux Recruiting NCT03311269 Phase 2 Sodium Tetradecyl Sulfate 1% Injection;Sodium Tetradecyl Sulfate 3% Injection
50 Efficacy of TR 987, Beta-1,3-1,6-D-glucan, in the Treatment of Chronic Venous Insufficiency Ulcers: a Two-arm, Double-blind, Placebo-controlled, Randomized Controlled Trial. Active, not recruiting NCT03154619 Phase 2 0.1% TR 987;Placebo gel

Search NIH Clinical Center for Venous Insufficiency

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Gotu Kola Extract
GOTU KOLA LIQUID

Cochrane evidence based reviews: venous insufficiency

Genetic Tests for Venous Insufficiency

Genetic tests related to Venous Insufficiency:

# Genetic test Affiliating Genes
1 Venous Insufficiency 29

Anatomical Context for Venous Insufficiency

MalaCards organs/tissues related to Venous Insufficiency:

40
Skin, Endothelial, Brain, Heart, Breast, Bone, Liver

Publications for Venous Insufficiency

Articles related to Venous Insufficiency:

(show top 50) (show all 4974)
# Title Authors PMID Year
1
Endovascular and medical therapy of May-Thurner syndrome: Case series and scoping literature review. 61
33752850 2021
2
Therapeutic potential of flavonoids in the treatment of chronic venous insufficiency. 61
33278582 2021
3
Protective effects of luteolin on the venous endothelium. 61
33469821 2021
4
Transmural pressure for conceptualisation of chronic venous insufficiency management. 61
33270505 2021
5
Private Payers' Varicose Vein Policies Are Inaccurate, Disparate, and Not Evidenced Based Which Mandates a Proposal for a Reasonable and Responsible Policy for the Treatment of Venous Disease. 61
33684590 2021
6
Wound cleansing for treating venous leg ulcers. 61
33734426 2021
7
In Response to Chronic Cerebrospinal Venous Insufficiency and Meniere's Disease: Interventional Versus Medical Therapy. 61
32579708 2021
8
In Reference to Chronic Cerebrospinal Venous Insufficiency and Meniere's Disease: Interventional Versus Medical Therapy. 61
32374415 2021
9
Regarding Chronic Cerebrospinal Venous Insufficiency and Meniere's Disease: Interventional Versus Medical Therapy. 61
32579709 2021
10
Clinical outcome of short-term compression after sclerotherapy for telangiectatic varicose veins. 61
32502730 2021
11
Time-Restricted Salutary Effects of Blood Flow Restoration on Venous Thrombosis and Vein Wall Injury in Mouse and Human Subjects. 61
33445952 2021
12
Petrosal Vein Involvement in Neurovascular Conflict in Trigeminal Neuralgia: Surgical Technique and Clinical Outcomes. 61
33377154 2021
13
Evaluation of physical activity level and exercise capacity in patients with varicose veins and chronic venous insufficiency. 61
33745365 2021
14
Early results of an Asian prospective multicenter VenaSeal real-world postmarket evaluation to investigate the efficacy and safety of cyanoacrylate endovenous ablation for varicose veins. 61
32387378 2021
15
A Case Report on Treatment of Nonhealing Leg Ulcer: Do Not Forget the Underlying Disease. 61
33745332 2021
16
Presentation patterns in women with pelvic venous disorders differ based on age of presentation. 61
32869695 2021
17
[Bacterial acute non necrosing cellulitis (erysipelas) in adult]. 61
33176944 2021
18
Sex differences in hospitalized adult patients with cellulitis: A prospective, multicenter study. 61
33508477 2021
19
Venous insufficiency, lymphocutaneous fistula, and use of autologous blood. 61
33665533 2021
20
Cavernous Venous Insufficiency: An Underestimated Vascular Disease Causing Erectile Dysfunction Resistant to Medical Treatment. 61
33127242 2021
21
Pelvic venous insufficiency secondary to iliac vein stenosis and ovarian vein reflux treated with iliac vein stenting alone. 61
33746048 2021
22
Validation of a Swedish version of a short patient-reported outcome measure for superficial venous insufficiency. 61
32736096 2021
23
Association between vein diameters, reflux characteristics, and clinical severity in patients with chronic venous insufficiency in Northwest China. 61
32730997 2021
24
Defining the human and health care costs of chronic venous insufficiency. 61
33757637 2021
25
Management of Lower Extremity Pain from Chronic Venous Insufficiency: A Comprehensive Review. 61
33704678 2021
26
Utility of high-frequency ultrasound in assessing cutaneous edema in venous ulcer patients. 61
33764579 2021
27
Prospective comparative study evaluating the role of flavonoids after endovenous thermal ablation. 61
33752526 2021
28
Use of Sponge-Foam Inserts in Compression Bandaging of Non-Healing Venous Leg Ulcers. 61
33786099 2021
29
Mechanochemical ablation for great and small saphenous veins insufficiency in patients with type III shunt. 61
32847473 2021
30
Limitations to self-management of adjustable compression wraps in the elderly: results of a prospective cohort study. 61
33739073 2021
31
Post-thrombotic syndrome - a position paper from European Society of Vascular Medicine. 61
33720757 2021
32
Clinical characteristics, inflammation and coagulation status in patients with immunological disease-related chronic cerebrospinal venous insufficiency. 61
33708863 2021
33
Hemodynamic and Radiological Classification of Ovarian Veins System Insufficiency. 61
33567554 2021
34
Endovenous radiofrequency for chronic superficial venous insufficiency: Clinical outcomes and impact in quality of life. 61
33546819 2021
35
Two-Year Follow-Up after Endovenous Closure with Short-Chain Cyanoacrylate versus Laser Ablation in Venous Insufficiency. 61
33562190 2021
36
A New Method Involving Percutaneous Application in the Treatment of Deep Venous Insufficiency: An Experimental Study With Internal Compression Therapy in a Porcine Model. 61
33078694 2021
37
Imaging findings of pelvic venous insufficiency in patients with postural orthostatic tachycardia syndrome. 61
32757696 2021
38
Association between lower extremity venous insufficiency and duration of atrial fibrillation. 61
33601963 2021
39
Quality of life outcomes for patients undergoing venous stenting for chronic deep venous disease. 61
33540137 2021
40
Performance of two clinical scales to assess quality of life in patients with post-thrombotic syndrome. 61
33548557 2021
41
[Long-term healing of a therapy-refractory venous leg ulcer after crural fasciectomy and split skin graft transplantation]. 61
32720166 2021
42
Clinical and hemodynamic outcome of morbidly obese patients with severe chronic venous insufficiency with and without bariatric surgery: A comparative study. 61
33540136 2021
43
Pelvic Congestion Syndrome. 61
33541587 2021
44
Prevalence and characteristics of older people with pressure ulcers and legs ulcers, in nursing homes in Barcelona. 61
33485786 2021
45
Efficacy of Human Recombinant Epidermal Growth Factors vs Conventional Therapy for the Treatment of Chronic Venous Ulcers: A Retrospective Case Series. 61
33591927 2021
46
Internal valvuloplasty combined with sleeve wrapping in the treatment of severe deep venous incompetence: A case report. 61
33530885 2021
47
Predictors for readmission due to cellulitis among Japanese patients. 61
33523517 2021
48
Effect of Pre-Procedure Clopidogrel With Iliac Vein Stenting in Non-Thrombotic Vein Lesions. 61
33602039 2021
49
Comparative efficacy and life quality effects of surgical stripping, radiofrequency ablation, and cyanoacrylate embolization in patients undergoing treatment for great saphenous vein insufficiency. 61
32741257 2021
50
Transabdominal duplex ultrasound and intravascular ultrasound planimetry measures of common iliac vein stenosis are significantly correlated in a symptomatic population. 61
33548556 2021

Variations for Venous Insufficiency

Expression for Venous Insufficiency

Search GEO for disease gene expression data for Venous Insufficiency.

Pathways for Venous Insufficiency

Pathways related to Venous Insufficiency according to GeneCards Suite gene sharing:

(show all 40)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.01 VWF VEGFA VCAM1 TIMP1 SELL PLAU
2
Show member pathways
13.38 VEGFA VCAM1 SERPINE1 PLAU MMP9 MMP1
3
Show member pathways
13.34 VWF VEGFA VCAM1 TIMP1 MMP9 MMP1
4
Show member pathways
13.01 VWF VEGFA TIMP1 SERPINE1 SELP SELL
5
Show member pathways
12.65 VEGFA VCAM1 MMP9 ITGA4 ICAM1
6
Show member pathways
12.62 VCAM1 TIMP1 SERPINE1 MMP9 MMP1 ITGA4
7
Show member pathways
12.37 VEGFA VCAM1 PLAU ICAM1
8
Show member pathways
12.3 SERPINE1 PLAT MTHFR ICAM1 F2 CRP
9
Show member pathways
12.29 VEGFA TIMP1 SERPINE1 MMP1
10
Show member pathways
12.24 SELP SELL MMP1 ITGA4 F2
11
Show member pathways
12.14 VWF VCAM1 ITGA4 ICAM1
12
Show member pathways
12.14 VWF SERPINE1 PLAU PLAT F5 F2
13 12.13 VCAM1 SELP SELL ITGA4 ICAM1
14 12.07 VCAM1 SELL ITGA4 ICAM1
15 12.07 VWF SERPINE1 PLAU PLAT F5 F2
16 12.04 VCAM1 SERPINE1 MMP9 ITGA4 ICAM1
17 12.02 VEGFA VCAM1 PLAT MMP9 IL1A ICAM1
18 12 SELP MMP9 IL1A ICAM1
19 11.94 SERPINE1 PLAU PLAT IL1A
20 11.91 VEGFA VCAM1 SERPINE1 IL1A ICAM1
21 11.87 VEGFA MMP1 IL1A ICAM1
22 11.81 VWF TIMP1 MMP9
23 11.72 VEGFA MMP9 MMP1
24 11.7 VEGFA PLAU PLAT MMP9
25 11.68 TIMP1 PLAU MMP9 ELN
26 11.67 VCAM1 ITGA4 ICAM1
27 11.54 VCAM1 SELP ICAM1
28
Show member pathways
11.53 VEGFA VCAM1 MMP9 MMP1 IL1A ICAM1
29 11.52 TIMP1 IL1A ICAM1
30 11.52 VEGFA PLAU PLAT
31 11.47 VCAM1 ITGA4 ICAM1
32 11.42 SELL MMP9 MMP1 ELN
33 11.4 SELP PLAU PLAT MMP9 ICAM1
34 11.34 PLAU MMP9 MMP1
35
Show member pathways
11.27 VEGFA TIMP1 CRP
36 11.22 TIMP1 SERPINE1 PLAU PLAT MMP9 MMP1
37 11.22 VEGFA VCAM1 TIMP1 MMP9 MMP1 IL1A
38 11.18 TIMP1 MMP9 ICAM1 F2
39 11.05 VEGFA TIMP1 MMP1
40 10.86 SERPINE1 PLAU PLAT

GO Terms for Venous Insufficiency

Cellular components related to Venous Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 10.1 VWF VCAM1 TIMP1 SERPINE1 PLAU PLAT
2 cell surface GO:0009986 9.91 VEGFA VCAM1 PLAU PLAT NDP ITGA4
3 extracellular matrix GO:0031012 9.8 VWF VEGFA TIMP1 NDP MMP9 MMP1
4 extracellular region GO:0005576 9.8 VWF VEGFA TIMP1 SERPINE1 PLAU PLAT
5 collagen-containing extracellular matrix GO:0062023 9.76 VWF SERPINE1 PLAT NDP MMP9 ICAM1
6 platelet alpha granule lumen GO:0031093 9.72 VWF VEGFA TIMP1 SERPINE1 F5
7 extracellular space GO:0005615 9.5 VWF VEGFA VCAM1 TIMP1 SERPINE1 SELP

Biological processes related to Venous Insufficiency according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 10.05 VWF VCAM1 SELP SELL ITGA4 ICAM1
2 cellular protein metabolic process GO:0044267 9.91 TIMP1 MMP1 F5 F2
3 regulation of immune response GO:0050776 9.91 VCAM1 SELL ITGA4 ICAM1
4 blood coagulation GO:0007596 9.91 VWF PLAU PLAT F5 F2
5 cytokine-mediated signaling pathway GO:0019221 9.91 VEGFA VCAM1 TIMP1 MMP9 MMP1 IL1A
6 response to hypoxia GO:0001666 9.88 VEGFA VCAM1 PLAU PLAT MTHFR ICAM1
7 hemostasis GO:0007599 9.78 VWF PLAU F5 F2
8 extracellular matrix disassembly GO:0022617 9.77 TIMP1 MMP9 MMP1
9 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.74 VCAM1 SELP ICAM1
10 leukocyte cell-cell adhesion GO:0007159 9.73 VCAM1 SELP ITGA4 ICAM1
11 cellular response to amyloid-beta GO:1904646 9.71 VCAM1 ITGA4 ICAM1
12 positive regulation of leukocyte migration GO:0002687 9.67 VEGFA SELP ITGA4
13 cellular response to UV-A GO:0071492 9.63 TIMP1 MMP9 MMP1
14 platelet degranulation GO:0002576 9.63 VWF VEGFA TIMP1 SERPINE1 SELP F5
15 plasminogen activation GO:0031639 9.62 PLAU PLAT
16 negative regulation of fibrinolysis GO:0051918 9.62 SERPINE1 F2
17 leukocyte tethering or rolling GO:0050901 9.62 VCAM1 SELP SELL ITGA4
18 positive regulation of leukocyte tethering or rolling GO:1903238 9.59 SELP ITGA4
19 smooth muscle cell migration GO:0014909 9.58 PLAU PLAT
20 membrane to membrane docking GO:0022614 9.56 VCAM1 ICAM1
21 fibrinolysis GO:0042730 9.56 SERPINE1 PLAU PLAT F2
22 connective tissue replacement involved in inflammatory response wound healing GO:0002248 9.55 TIMP1 IL1A
23 cell-cell adhesion in response to extracellular stimulus GO:0140039 9.52 VCAM1 ITGA4
24 leukocyte migration GO:0050900 9.5 SELP SELL MMP9 MMP1 ITGA4 ICAM1
25 extracellular matrix organization GO:0030198 9.23 VWF VCAM1 SERPINE1 MMP9 MMP1 ITGA4

Molecular functions related to Venous Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.83 PLAU PLAT MMP9 MMP1 F2
2 cytokine activity GO:0005125 9.67 VEGFA TIMP1 NDP IL1A
3 heparin binding GO:0008201 9.62 VEGFA SELP SELL F2
4 integrin binding GO:0005178 9.46 VWF VCAM1 ITGA4 ICAM1
5 oligosaccharide binding GO:0070492 9.4 SELP SELL
6 glycosphingolipid binding GO:0043208 9.26 SELP SELL
7 protease binding GO:0002020 9.26 VWF TIMP1 SERPINE1 SELL
8 serine-type endopeptidase activity GO:0004252 9.02 PLAU PLAT MMP9 MMP1 F2

Sources for Venous Insufficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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