MCID: VNS003
MIFTS: 54

Venous Insufficiency

Categories: Blood diseases, Cardiovascular diseases

Aliases & Classifications for Venous Insufficiency

MalaCards integrated aliases for Venous Insufficiency:

Name: Venous Insufficiency 12 30 45 15 74
Peripheral Venous Insufficiency 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10128
ICD9CM 36 459.81
MeSH 45 D014689
NCIt 51 C127822
SNOMED-CT 69 20696009
ICD10 34 I87.2
UMLS 74 C0042485

Summaries for Venous Insufficiency

Disease Ontology : 12 A vein disease that is characterized by impaired flow of blood through the veins.

MalaCards based summary : Venous Insufficiency, also known as peripheral venous insufficiency, is related to lipodermatosclerosis and post-thrombotic syndrome. An important gene associated with Venous Insufficiency is PLAT (Plasminogen Activator, Tissue Type), and among its related pathways/superpathways are Innate Immune System and Integrin Pathway. The drugs Hesperidin and Sodium Tetradecyl Sulfate have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and bone, and related phenotypes are cardiovascular system and homeostasis/metabolism

Related Diseases for Venous Insufficiency

Diseases in the Venous Insufficiency family:

Chronic Venous Insufficiency

Diseases related to Venous Insufficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 214)
# Related Disease Score Top Affiliating Genes
1 lipodermatosclerosis 32.4 MMP1 PLAT
2 post-thrombotic syndrome 32.3 F2 ICAM1 SERPINE1
3 chronic venous insufficiency 32.1 ICAM1 ITGA4 MMP1 MMP9 PLAT SELL
4 multiple sclerosis 30.7 ICAM1 ITGA4 MMP9 VCAM1
5 thrombophlebitis 30.1 F2 PLAT SERPINE1
6 vein disease 30.1 F2 PLAT SERPINE1
7 thrombophilia due to thrombin defect 29.8 F2 PLAT SERPINE1 VWF
8 varicose veins 29.8 F2 MMP1 MMP9 TIMP1 VWF
9 thrombosis 29.8 F2 PLAT SELP SERPINE1 VWF
10 thrombophilia 29.6 F2 SERPINE1 VWF
11 arteriosclerosis obliterans 29.5 ICAM1 SELP VCAM1
12 pulmonary disease, chronic obstructive 28.7 CRP MMP1 MMP9 TIMP1
13 vasculitis 28.6 CRP ICAM1 SELL VCAM1 VWF
14 systemic lupus erythematosus 28.2 CRP F2 ICAM1 VCAM1 VWF
15 arteriosclerosis 28.2 CRP ICAM1 MMP9 SELP SERPINE1 VCAM1
16 peripheral vascular disease 28.1 CRP F2 PLAT SELP SERPINE1 VCAM1
17 heart disease 27.9 CRP F2 ICAM1 PLAT SELP SERPINE1
18 vascular disease 27.8 CRP F2 MMP9 PLAT SELP SERPINE1
19 fibrinolytic defect 10.4 PLAT SERPINE1
20 plasminogen activator inhibitor-1 deficiency 10.4 PLAT SERPINE1
21 argentine hemorrhagic fever 10.4 PLAT SERPINE1
22 central serous chorioretinopathy 10.4 PLAT SERPINE1
23 intracranial embolism 10.4 F2 PLAT
24 cryptogenic cirrhosis 10.3 F2 SERPINE1
25 toxicodendron dermatitis 10.3 ICAM1 SELL
26 marantic endocarditis 10.3 F2 PLAT
27 acute cor pulmonale 10.3 PLAT SERPINE1
28 amaurosis fugax 10.3 MMP9 SERPINE1
29 livedoid vasculitis 10.3 F2 SERPINE1
30 plummer's disease 10.3 ICAM1 SELL
31 autoimmune inner ear disease 10.3 MMP9 TIMP1
32 chronic eosinophilic pneumonia 10.3 ICAM1 ITGA4
33 pediatric multiple sclerosis 10.2 ITGA4 MMP9
34 carotid artery thrombosis 10.2 PLAT SELP SERPINE1
35 peliosis hepatis 10.2 F2 ITGA4 SELL
36 disseminated intravascular coagulation 10.2 F2 PLAT SERPINE1
37 fungal keratitis 10.2 MMP9 TIMP1
38 lymphocytic vasculitis 10.2 ICAM1 VCAM1
39 hydrocele 10.2 ICAM1 ITGA4
40 cryptogenic organizing pneumonia 10.2 MMP9 TIMP1
41 cortical thymoma 10.2 ICAM1 VCAM1
42 conjunctival nevus 10.2 MMP9 TIMP1
43 shwartzman phenomenon 10.2 ICAM1 VCAM1
44 arthus reaction 10.2 ICAM1 SELL
45 conjunctivochalasis 10.2 MMP1 TIMP1
46 portal vein thrombosis 10.2 F2 SELP SERPINE1
47 acute pulmonary heart disease 10.2 PLAT SERPINE1
48 retinal vascular occlusion 10.2 F2 SELP
49 brachydactyly, type e2 10.2 ICAM1 VCAM1
50 active peptic ulcer disease 10.1 F2 VWF

Comorbidity relations with Venous Insufficiency via Phenotypic Disease Network (PDN): (show all 23)


Acute Cystitis Aortic Valve Disease 1
Bronchitis Chronic Kidney Failure
Chronic Myocardial Ischemia Chronic Pulmonary Heart Disease
Decubitus Ulcer Deficiency Anemia
Familial Atrial Fibrillation Femoral Vein Thrombophlebitis
Generalized Atherosclerosis Heart Disease
Hypertension, Essential Hypothyroidism
Iron Deficiency Anemia Ischemic Heart Disease
Mitral Valve Disease Osteoporosis
Peripheral Vascular Disease Post-Thrombotic Syndrome
Protein-Energy Malnutrition Schizophreniform Disorder
Tinea Pedis

Graphical network of the top 20 diseases related to Venous Insufficiency:



Diseases related to Venous Insufficiency

Symptoms & Phenotypes for Venous Insufficiency

MGI Mouse Phenotypes related to Venous Insufficiency:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.23 CRP F2 ICAM1 ITGA4 MMP9 PLAT
2 homeostasis/metabolism MP:0005376 10.15 CRP F2 ICAM1 MMP1 MMP9 PLAT
3 hematopoietic system MP:0005397 10.14 F2 ICAM1 ITGA4 MMP9 PLAT SELL
4 immune system MP:0005387 10.13 CRP F2 ICAM1 ITGA4 MMP1 MMP9
5 growth/size/body region MP:0005378 10.09 F2 ICAM1 MMP9 PLAT SELL SELP
6 mortality/aging MP:0010768 9.85 F2 ICAM1 ITGA4 MMP9 PLAT SELP
7 integument MP:0010771 9.8 F2 ICAM1 MMP9 PLAT SELL SELP
8 neoplasm MP:0002006 9.43 ICAM1 MMP1 MMP9 SELL SERPINE1 TIMP1
9 respiratory system MP:0005388 9.17 F2 MMP9 PLAT SELL SELP SERPINE1

Drugs & Therapeutics for Venous Insufficiency

Drugs for Venous Insufficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 133)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hesperidin Approved, Investigational Phase 4,Phase 3 520-26-3 53477767
2
Sodium Tetradecyl Sulfate Approved, Investigational Phase 4,Phase 2,Not Applicable 1191-50-0, 139-88-8 14492 5248
3
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
4
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
5
Racepinephrine Approved Phase 4 329-65-7 838
6
Polidocanol Approved Phase 4,Phase 3 9002-92-0
7
Rivaroxaban Approved Phase 4,Not Applicable 366789-02-8
8
Glucosamine Approved, Investigational Phase 4,Early Phase 1 3416-24-8 439213
9
Serine Approved, Nutraceutical Phase 4,Not Applicable 56-45-1 5951
10
Troxerutin Investigational Phase 4,Not Applicable 7085-55-4 5486699
11
Coumarin Experimental Phase 4 91-64-5 323
12 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
13 Anesthetics Phase 4,Not Applicable
14 Anesthetics, Local Phase 4,Not Applicable
15 Anticoagulants Phase 4,Phase 3,Phase 2,Not Applicable
16 Salicylates Phase 4,Phase 1,Phase 2
17 Heparinoids Phase 4
18 Calamus Phase 4
19 Sclerosing Solutions Phase 4,Phase 3,Phase 2,Not Applicable
20 Aminaftone Phase 4
21 Coagulants Phase 4,Phase 3
22 Hemostatics Phase 4,Phase 3
23 Sympathomimetics Phase 4
24 Neurotransmitter Agents Phase 4
25 Vasoconstrictor Agents Phase 4
26 Adrenergic Agonists Phase 4
27 Anti-Arrhythmia Agents Phase 4
28 Anti-Asthmatic Agents Phase 4
29 Autonomic Agents Phase 4
30 Sodium Channel Blockers Phase 4
31 Adrenergic beta-Agonists Phase 4
32 Central Nervous System Depressants Phase 4,Not Applicable
33 Peripheral Nervous System Agents Phase 4
34 Mydriatics Phase 4
35 Diuretics, Potassium Sparing Phase 4
36 Adrenergic alpha-Agonists Phase 4
37 Epinephryl borate Phase 4
38 Bronchodilator Agents Phase 4
39 Adrenergic Agents Phase 4
40 Respiratory System Agents Phase 4
41 Anti-Inflammatory Agents Phase 4,Not Applicable
42
protease inhibitors Phase 4,Not Applicable
43 Antithrombins Phase 4,Not Applicable
44 HIV Protease Inhibitors Phase 4,Not Applicable
45 Antithrombin III Phase 4,Not Applicable
46 Factor Xa Inhibitors Phase 4,Not Applicable
47 Serine Proteinase Inhibitors Phase 4,Not Applicable
48 Antimetabolites Phase 4
49 Hypolipidemic Agents Phase 4
50 Fibrinolytic Agents Phase 4,Phase 3,Not Applicable

Interventional clinical trials:

(show top 50) (show all 238)
# Name Status NCT ID Phase Drugs
1 Clinical Non-inferiority Study Between Diosmin 600mg & Diosmin + Hesperidin in Symptomatic Chronic Venous Insufficiency Completed NCT03471910 Phase 4 Diosmin;Diosmin / Hesperidin
2 Efficacy and Safety of the Use of Venocur Triplex® in Patients With Chronic Venous Insufficiency Completed NCT00835822 Phase 4 Venocur Triplex®;placebo
3 Tolerability of Antistax® in Patients Suffering From Chronic Venous Insufficiency (CVI) Completed NCT02184234 Phase 4 Antistax film coated tablets
4 Efficacy and Safety of Coumarin and Troxerutin in the Symptomatic Treatment of Chronic Venous Insufficiency Completed NCT01848210 Phase 4 Coumarin/troxerutin;Placebo
5 Efficacy and Safety of Esarin Gel in Chronic Venous Insufficiency and Varicose Veins Completed NCT02346058 Phase 4 Esarin Gel
6 RCT Comparing Standard Cannula Delivered FS, UGFS and ClariVein® in the Management of SVI Withdrawn NCT02010437 Phase 4 Sodium Tetradecyl Sulphate (STS)
7 Iliac Vein Stenting in Advanced Chronic Venous Insufficiency Completed NCT02149212 Phase 4 Phlebotonic
8 Practicability of Gliding Aids for Medical Compression Stockings Completed NCT01432795 Phase 4
9 Radiofrequency Ablation vs Laser Ablation of the Incompetent Greater Saphenous Vein Completed NCT02236338 Phase 4
10 Radiofrequency Ablation vs. Laser Ablation of the Incompetent Small Saphenous Vein Terminated NCT02248740 Phase 4
11 Neuromuscular Electrical Therapy in Venous Ulcers Completed NCT01372020 Phase 4
12 Laser Ablation Versus Mechanochemical Ablation Trial Recruiting NCT02627846 Phase 4 Lidocaine with 1:200,000 epinephrine solution;Lidocaine with 1:200,000 epinephrine solution;Sodium Bicarbonate;Sodium Tetradecyl Sulphate
13 SocknLeg - a User Friendly Medical Compression Study of a Modified Application of a Medical Device Completed NCT02621632 Phase 4
14 The Fate Of Calf Perforators After Endovenous Laser Ablation Of Saphenous Veins Completed NCT01458795 Phase 4
15 Study of Antiinflammatory Effects of Detralex (Daflon) Enrolling by invitation NCT01654016 Phase 4 Detralex
16 A Pilot Trial of the Use of ReCell® Autologous Cell Harvesting Device for Venous Leg Ulcers Completed NCT01743053 Phase 4
17 Polidocanol Versus Glucose Treatment of Telangiectasia Trial Completed NCT02657252 Phase 4 Glucose;Polidocanol with Glucose
18 Study Protocol Comparing Polidocanol Versus Hypertonic Glucose for Treatment of Reticular Veins Completed NCT02054325 Phase 4 Polidocanol with Glucose;Glucose
19 ClosureFAST vs. Laser Ablation for the Treatment of GSV Disease: A Multicenter, Single-Blinded, Randomized Study. Completed NCT00509392 Phase 4
20 Rivaroxaban With Diosmine in Long-term Treatment of DVT Active, not recruiting NCT03413618 Phase 4 Rivaroxaban;Diosmin
21 Study of Foam Sclerotherapy Versus Ambulatory Phlebectomy Recruiting NCT03416413 Phase 4 Foam sclerotherapy
22 Prospective Evaluation of the QoL of Patients With PTS Who Receive Compression Therapy and Sulodexide Terminated NCT02512601 Phase 4 Sulodexide
23 Study to Evaluate the Efficacy and Tolerability of Venaflon Use in Reducing the Symptoms Caused by Chronic Venous Insufficiency When Compared With Daflon Unknown status NCT01477281 Phase 3 Daflon;Venaflon (Diosmin and Hesperidin)
24 Study to Assess the Efficacy and Safety of Endolex Forte VErsus Diosmin and Hesperidin in Reducing VeNous Insufficiency Unknown status NCT02927483 Phase 3
25 Efficacy and Tolerability of the Use of Varicell Compared With Daflon Unknown status NCT01321619 Phase 3 Daflon;Varicell placebo
26 Comparative Efficacy of Two Preparations of the Association Diosmin (450 mg) + Hesperidin (50 mg) in the Treatment of Chronic Venous Insufficiency (CVI) Unknown status NCT01110512 Phase 3 Flavonid;Daflon
27 Safety and Efficacy Study of ICXP007 With Compression Bandaging for the Treatment of Non-Infected Venous Leg Ulcers Unknown status NCT00232973 Phase 3 ICXP007
28 PRP ULCERAS: Clinical Trial Phase III Unknown status NCT02213952 Phase 3 Platelet-Rich Plasma
29 Treatment Trial for Post-Thrombotic Syndrome Unknown status NCT00633971 Phase 3
30 Efficacy and Tolerability of Antistax® in Male and Female Patients Suffering From Chronic Venous Insufficiency Completed NCT02191254 Phase 3 Antistax®;Placebo
31 Assess the Efficacy and Tolerability of Antistax Film-coated Tablets in Patients With Chronic Venous Insufficiency Completed NCT00855179 Phase 3 Red vine leaf extract (AS 195);Placebo
32 Crenobalneotherapy in the Treatment of Chronic Venous Insufficiency Completed NCT01956318 Phase 3
33 Efficacy and Tolerability CVI (A 12-week, Double-blind, Randomised, Placebo-controlled, Multicentre Trial (CVI) Completed NCT00292435 Phase 3 Read vine leaf extract (AS 195)
34 The Influence of Compression Stockings on Skin's Barrier Function at Patients With Chronic Venous Disease Completed NCT00196443 Phase 2, Phase 3
35 THERMES ET VEINES: Spa for Prevention of Leg Ulcers Completed NCT00838500 Phase 3 Immediate spa treatment;Late spa treatment
36 Efficacy on Volume Reduction and Tolerance of Progressiv' Medical Compressive Therapy (MCT) V0322 BC in Patients With Chronic Venous Oedema Completed NCT01402921 Phase 3
37 Clinical Study of BNS003 on Swelling in Legs Due to Venous Reflux Completed NCT02211898 Phase 3 BNS003
38 ESGVS: Sclerotherapy With Lauromacrogol Completed NCT00348764 Phase 3 lauromacrogol
39 Clinical Effectiveness of Topical Autologous Platelet Gel for the Treatment of Venous Ulcers Withdrawn NCT00273234 Phase 3
40 Evaluation of Long-Term Sequelae After Thrombophlebitis, i.e. Deep Venous Thrombosis of the Lower Extremities Completed NCT00628576 Phase 3 unfractionated heparin;Tinzaparin (Leo)
41 Polidocanol Endovenous Microfoam (PEM) Versus Vehicle for the Treatment of Saphenofemoral Junction (SFJ) Incompetence Completed NCT01231373 Phase 3 polidocanol injectable foam, 0.125%;polidocanol injectable foam, 0.5%;polidocanol injectable foam, 1.0%;Vehicle
42 Efficacy and Safety Study of Polidocanol Injectable Foam for the Treatment of Saphenofemoral Junction (SFJ) Incompetence Completed NCT01072877 Phase 3 Polidocanol injectable foam (PEM);Placebo Vehicle
43 The MUFFIN-PTS Trial Not yet recruiting NCT03833024 Phase 3 Micronized Purified Flavonoid Fraction;Placebo
44 EVENT: Hydrotherapy and Deep Venous Thrombosis Terminated NCT00348907 Phase 3 thermal cure;late thermal cure
45 Safety and Efficacy Trial of HP802-247 in the Treatment of Chronic Venous Leg Ulcers Terminated NCT01853384 Phase 3
46 Study Investigating the Safety and Efficacy of HP802-247 in the Treatment of Venous Leg Ulcers >12 cm2 to ≤ 36 cm2 Completed NCT01737762 Phase 3
47 Acute Venous Thrombosis: Thrombus Removal With Adjunctive Catheter-Directed Thrombolysis Completed NCT00790335 Phase 3 Recombinant tissue plasminogen activator (rt-PA)
48 Full-Leg vs Below-Knee Elastic Stockings for Prevention of the Post-Thrombotic Syndrome Completed NCT00426075 Phase 3
49 Pediatric High-Risk Deep Venous Thrombosis Lytic Outcomes Trial Withdrawn NCT02767232 Phase 3 Recombinant tissue plasminogen activator (rt-PA);Standard Anticoagulation Therapy
50 The SOX Trial: Compression Stockings to Prevent the Post-Thrombotic Syndrome Completed NCT00143598 Phase 3

Search NIH Clinical Center for Venous Insufficiency

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: venous insufficiency

Genetic Tests for Venous Insufficiency

Genetic tests related to Venous Insufficiency:

# Genetic test Affiliating Genes
1 Venous Insufficiency 30

Anatomical Context for Venous Insufficiency

MalaCards organs/tissues related to Venous Insufficiency:

42
Skin, Testes, Bone, Brain, Endothelial, Monocytes, Placenta

Publications for Venous Insufficiency

Articles related to Venous Insufficiency:

(show top 50) (show all 1181)
# Title Authors Year
1
Dystrophic Calcifications in Chronic Venous Insufficiency. ( 30551796 )
2019
2
Protocol for a longitudinal cohort study: determination of risk factors for the development of first venous leg ulcer in people with chronic venous insufficiency, the VEINS (venous insufficiency in South Florida) cohort. ( 30610020 )
2019
3
Endovenous cyanoacrylate glue to treat varicose veins and chronic venous insufficiency-Experience gained from our first 100+ truncal venous ablations in a multi-ethnic Asian population using the Medtronic VenaSeal™ Closure System. ( 30691376 )
2019
4
Prevalence, risk factors, and evaluation of iliocaval obstruction in advanced chronic venous insufficiency. ( 30765330 )
2019
5
Commentary on "A Wearable Compression Device Normalises Calf Muscle Pump Function in Chronic Venous Insufficiency by Applying Appropriate Pressures for Each Postural Position". ( 30777601 )
2019
6
Ultrasound-based topographic analysis of tributary vein connection with the saphenous vein during ambulatory conservative hemodynamic correction of chronic venous insufficiency. ( 30777672 )
2019
7
Effects of preventive use of compression stockings for elderly with chronic venous insufficiency and swollen legs: a systematic review and meta-analysis. ( 30845919 )
2019
8
Chronic Venous Insufficiency and Dystrophic Subcutaneous Calcification. ( 30896399 )
2019
9
"Waiting for Science to Catch up with Practice": an examination of 10-year YouTube trends in discussions of chronic cerebral spinal venous insufficiency treatment for multiple sclerosis. ( 30913949 )
2019
10
Evaluation of hemorrhoidal disease and lower extremity venous insufficiency in primary adult varicocele: A prospective controlled study. ( 30836835 )
2019
11
Comparison of Four Haemodynamic Tests that Quantify Superficial Venous Insufficiency. ( 30898493 )
2019
12
A pilot study of venous flow augmentation using a novel mechanical graded intermittent sequential compression device for venous insufficiency. ( 30612969 )
2019
13
Regarding "Retrograde administration of ultrasound-guided endovenous microfoam chemical ablation for the treatment of superficial venous insufficiency". ( 30771837 )
2019
14
Current Therapeutic Interventions in Lower Extremity Venous Insufficiency: a Comprehensive Review. ( 30830460 )
2019
15
A near-infrared spectroscopy-assisted test discriminates patients with peripheral arterial disease and venous insufficiency with changes of foot oxygenation following light elastic compression therapy. ( 30838936 )
2019
16
MR venography using time-resolved imaging in interventional management of pelvic venous insufficiency. ( 30847564 )
2019
17
Retrograde administration of ultrasound-guided endovenous microfoam chemical ablation for the treatment of superficial venous insufficiency. ( 29909854 )
2018
18
Experience of Using Shear Wave Elastography Imaging in Superficial Venous Insufficiency of the Lower Extremity. ( 29634667 )
2018
19
Thermal and Nonthermal Endovenous Ablation Options for Treatment of Superficial Venous Insufficiency. ( 29502779 )
2018
20
The influence of exercise on ulcer healing in patients with chronic venous insufficiency. ( 29368880 )
2018
21
A retrospective study of a new n-butyl-2-cyanoacrylate glue ablation catheter incorporated with application guiding light for the treatment of venous insufficiency: Twelve-month results. ( 29642798 )
2018
22
Systematic review and meta-analysis of endovascular and surgical revascularization for patients with chronic lower extremity venous insufficiency and varicose veins. ( 29421005 )
2018
23
Chronic Cerebro-Spinal Venous Insufficiency in Multiple Sclerosis: Is It the End? ( 29629362 )
2018
24
Endovenous Thermal Ablation of Recurrent Varicose Veins due to Residual Great Saphenous Venous Insufficiency After Saphenous Venous Surgery: A Comparative Study. ( 29781902 )
2018
25
Varicose Veins and Lower Extremity Venous Insufficiency. ( 29628617 )
2018
26
US budget impact of increased payer adoption of the Flexitouch advanced pneumatic compression device in lymphedema patients with advanced chronic venous insufficiency and multiple infections. ( 29975564 )
2018
27
Plasma concentration of selected biochemical markers of endothelial dysfunction in women with various severity of chronic venous insufficiency (CVI)-A pilot study. ( 29377939 )
2018
28
Efficacy of subcutaneous lidocaine injection in venous insufficiency: a prospective, randomized, controlled study, and new treatment protocol. ( 29950758 )
2018
29
Iliac vein stenosis is an underdiagnosed cause of pelvic venous insufficiency. ( 29292119 )
2018
30
Suppressed networks of inflammatory mediators characterize chronic venous insufficiency. ( 29439934 )
2018
31
Venous insufficiency: Differences in the content of trace elements. A preliminary report. ( 29616754 )
2018
32
Placentas from women with pregnancy-associated venous insufficiency show villi damage with evidence of hypoxic cellular stress. ( 29626597 )
2018
33
Implication of the PI3K/Akt/mTOR Pathway in the Process of Incompetent Valves in Patients with Chronic Venous Insufficiency and the Relationship with Aging. ( 30057669 )
2018
34
Chronic cerebrospinal venous insufficiency, chlamydia and multiple sclerosis. ( 30200825 )
2018
35
Response to "Chronic cerebrospinal venous insufficiency, chlamydia and multiple sclerosis": CCSVI, Chlamydia pneumoniae and multiple sclerosis clarification. ( 30217137 )
2018
36
Frequency and Significance of Perforating Venous Insufficiency in Patients with Chronic Venous Insufficiency of Lower Extremity. ( 30002576 )
2018
37
Chronic venous insufficiency: a new concept to understand pathophysiology at the microvascular level - a pilot study. ( 30067139 )
2018
38
Correlation of obesity & comorbid conditions with chronic venous insufficiency: Results of a single-centre study. ( 30082571 )
2018
39
Validation of a Gravitational Model to Study Local Endogenous Biomarkers in Chronic Venous Insufficiency. ( 30181065 )
2018
40
Influence of Diosmin Treatment on the Level of Oxidative Stress Markers in Patients with Chronic Venous Insufficiency. ( 30228853 )
2018
41
Chronic venous insufficiency and varicose veins of the lower extremities. ( 30360023 )
2018
42
Acroangiodermatitis of Mali (Pseudo-Kaposi Sarcoma) Associated with Chronic Venous Insufficiency and Obesity: A Case Report. ( 30457563 )
2018
43
An Osteopathic Approach to Stasis Dermatitis and Chronic Venous Insufficiency. ( 30476998 )
2018
44
Duplex ultrasound findings and clinical classification of lower extremity chronic venous insufficiency in a Thai population. ( 30477978 )
2018
45
An Automatic Classification Method on Chronic Venous Insufficiency Images. ( 30560945 )
2018
46
LivRelief varicose veins cream in the treatment of chronic venous insufficiency of the lower limbs: A 6-week single arm pilot study. ( 30596677 )
2018
47
Evaluation of Arterial Stiffness Using Pulse Wave Velocity and Augmentation Index in Patients with Chronic Venous Insufficiency. ( 30631600 )
2018
48
Impact of copper compression stockings on venous insufficiency and lipodermatosclerosis: A randomised controlled trial. ( 30149775 )
2018
49
A case of lipomembranous panniculitis with a dramatic response to the treatment of venous insufficiency. ( 29991978 )
2018
50
Carboxytherapy: Controls the inflammation and enhances the production of fibronectin on wound healing under venous insufficiency. ( 30467979 )
2018

Variations for Venous Insufficiency

Expression for Venous Insufficiency

Search GEO for disease gene expression data for Venous Insufficiency.

Pathways for Venous Insufficiency

Pathways related to Venous Insufficiency according to GeneCards Suite gene sharing:

(show all 36)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.87 CRP ICAM1 ITGA4 MMP1 MMP9 SELL
2
Show member pathways
13.27 F2 ICAM1 ITGA4 MMP1 MMP9 SERPINE1
3
Show member pathways
13.21 ICAM1 MMP1 MMP9 TIMP1 VCAM1 VWF
4
Show member pathways
12.69 F2 ITGA4 MMP1 PLAT SELL SELP
5
Show member pathways
12.53 ICAM1 ITGA4 MMP9 VCAM1
6
Show member pathways
12.45 ICAM1 ITGA4 MMP1 MMP9 SERPINE1 TIMP1
7
Show member pathways
12.23 CRP F2 ICAM1 PLAT SERPINE1
8
Show member pathways
12.11 F2 ITGA4 MMP1 SELL SELP
9
Show member pathways
12.09 F2 ICAM1 ITGA4 MMP1 MMP9 VCAM1
10
Show member pathways
12.08 F2 PLAT SERPINE1 VWF
11
Show member pathways
12.03 ICAM1 ITGA4 VCAM1 VWF
12 11.99 F2 PLAT SERPINE1 VWF
13 11.98 ICAM1 MMP9 PLAT VCAM1
14 11.96 ICAM1 ITGA4 SELL VCAM1
15 11.96 ICAM1 ITGA4 SELL SELP VCAM1
16
Show member pathways
11.93 F2 MMP9 PLAT
17 11.9 ICAM1 MMP9 SELP
18 11.86 ICAM1 MMP9 VCAM1
19 11.86 ICAM1 ITGA4 MMP9 SERPINE1 VCAM1
20 11.79 ICAM1 SERPINE1 VCAM1
21
Show member pathways
11.78 MMP1 MMP9 TIMP1
22 11.78 ICAM1 MMP1 MMP9 TIMP1 VCAM1
23 11.73 MMP9 TIMP1 VWF
24
Show member pathways
11.58 ICAM1 MMP1 MMP9 VCAM1
25 11.46 ICAM1 SELP VCAM1
26 11.42 ICAM1 MMP9 PLAT SELP
27 11.4 ICAM1 ITGA4 VCAM1
28 11.33 MMP1 MMP9 SELL
29 11.03 MMP9 PLAT
30 10.99 F2 MMP1
31 10.94 MMP1 TIMP1
32 10.89 MMP1 MMP9
33 10.85 ICAM1 VCAM1
34 10.85 F2 ICAM1 MMP9 TIMP1
35 10.81 MMP1 MMP9 PLAT SERPINE1 TIMP1
36 10.75 PLAT SERPINE1

GO Terms for Venous Insufficiency

Cellular components related to Venous Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.92 CRP F2 MMP1 MMP9 PLAT SERPINE1
2 cell surface GO:0009986 9.8 ICAM1 ITGA4 PLAT SELL VCAM1
3 external side of plasma membrane GO:0009897 9.65 F2 ICAM1 SELL SELP VCAM1
4 extracellular matrix GO:0031012 9.61 MMP1 MMP9 TIMP1
5 extracellular exosome GO:0070062 9.61 F2 ICAM1 ITGA4 MMP9 PLAT SERPINE1
6 collagen-containing extracellular matrix GO:0062023 9.55 ICAM1 MMP9 PLAT SERPINE1 VWF
7 platelet alpha granule lumen GO:0031093 9.54 SERPINE1 TIMP1 VWF
8 extracellular space GO:0005615 9.28 CRP F2 ICAM1 MMP9 PLAT SELP

Biological processes related to Venous Insufficiency according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.88 ICAM1 ITGA4 SELL SELP VCAM1 VWF
2 regulation of immune response GO:0050776 9.8 ICAM1 ITGA4 SELL VCAM1
3 response to hypoxia GO:0001666 9.77 ICAM1 PLAT VCAM1
4 cytokine-mediated signaling pathway GO:0019221 9.77 ICAM1 MMP1 MMP9 TIMP1 VCAM1
5 response to lipopolysaccharide GO:0032496 9.76 ICAM1 SELP VCAM1
6 platelet degranulation GO:0002576 9.73 SELP SERPINE1 TIMP1 VWF
7 extracellular matrix disassembly GO:0022617 9.69 MMP1 MMP9 TIMP1
8 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.63 ICAM1 SELP VCAM1
9 extracellular matrix organization GO:0030198 9.63 ICAM1 ITGA4 MMP9 SERPINE1 VCAM1 VWF
10 endodermal cell differentiation GO:0035987 9.6 ITGA4 MMP9
11 negative regulation of proteolysis GO:0045861 9.58 F2 PLAT
12 calcium-mediated signaling using intracellular calcium source GO:0035584 9.57 SELP VCAM1
13 blood coagulation, intrinsic pathway GO:0007597 9.56 F2 VWF
14 leukocyte cell-cell adhesion GO:0007159 9.56 ICAM1 ITGA4 SELP VCAM1
15 positive regulation of blood coagulation GO:0030194 9.55 F2 SERPINE1
16 positive regulation of leukocyte migration GO:0002687 9.54 ITGA4 SELP
17 negative regulation of fibrinolysis GO:0051918 9.52 F2 SERPINE1
18 fibrinolysis GO:0042730 9.5 F2 PLAT SERPINE1
19 membrane to membrane docking GO:0022614 9.48 ICAM1 VCAM1
20 leukocyte migration GO:0050900 9.43 ICAM1 ITGA4 MMP1 MMP9 SELL SELP
21 leukocyte tethering or rolling GO:0050901 8.92 ITGA4 SELL SELP VCAM1

Molecular functions related to Venous Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 9.58 F2 SELL SELP
2 serine-type endopeptidase activity GO:0004252 9.56 F2 MMP1 MMP9 PLAT
3 integrin binding GO:0005178 9.54 ICAM1 VCAM1 VWF
4 cell adhesion molecule binding GO:0050839 9.33 ITGA4 SELL VCAM1
5 oligosaccharide binding GO:0070492 9.32 SELL SELP
6 glycosphingolipid binding GO:0043208 8.96 SELL SELP
7 protease binding GO:0002020 8.92 SELL SERPINE1 TIMP1 VWF

Sources for Venous Insufficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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