MCID: VNS003
MIFTS: 54

Venous Insufficiency

Categories: Cardiovascular diseases

Aliases & Classifications for Venous Insufficiency

MalaCards integrated aliases for Venous Insufficiency:

Name: Venous Insufficiency 12 29 44 15 73
Peripheral Venous Insufficiency 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10128
ICD9CM 35 459.81
MeSH 44 D014689
SNOMED-CT 68 20696009
ICD10 33 I87.2
UMLS 73 C0042485

Summaries for Venous Insufficiency

Disease Ontology : 12 A vein disease that is characterized by impaired flow of blood through the veins.

MalaCards based summary : Venous Insufficiency, also known as peripheral venous insufficiency, is related to lipodermatosclerosis and post-thrombotic syndrome. An important gene associated with Venous Insufficiency is PLAT (Plasminogen Activator, Tissue Type), and among its related pathways/superpathways are Innate Immune System and Integrin Pathway. The drugs Lidocaine and Polidocanol have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and testes, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 76 Venous insufficiency can refer... more...

Related Diseases for Venous Insufficiency

Diseases in the Venous Insufficiency family:

Chronic Venous Insufficiency

Diseases related to Venous Insufficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 203)
# Related Disease Score Top Affiliating Genes
1 lipodermatosclerosis 32.5 MMP1 PLAT
2 post-thrombotic syndrome 32.4 F2 ICAM1 SERPINE1
3 chronic venous leg ulcers 30.1 ITGA4 MMP9 TIMP1
4 thrombophlebitis 30.1 F2 PLAT SERPINE1
5 buerger disease 30.1 F2 SERPINE1
6 multiple sclerosis 29.7 ICAM1 ITGA4 MMP9 TIMP1 VCAM1
7 chronic venous insufficiency 29.6 ICAM1 ITGA4 MMP1 MMP9 PLAT SELL
8 thrombophilia due to thrombin defect 29.5 F2 PLAT SERPINE1 VWF
9 arteriosclerosis obliterans 29.3 ICAM1 SELP VCAM1
10 thrombosis 29.1 F2 PLAT SELP SERPINE1 VWF
11 thrombophilia 29.0 F2 PLAT SERPINE1 VWF
12 peripheral artery disease 28.8 CRP SELP VCAM1
13 varicose veins 28.7 F2 MMP1 MMP9 TIMP1 VWF
14 pulmonary disease, chronic obstructive 27.9 CRP MMP1 MMP9 TIMP1
15 vasculitis 26.9 CRP ICAM1 SELL VCAM1 VWF
16 arteriosclerosis 26.6 CRP ICAM1 MMP9 SELP SERPINE1 VCAM1
17 peripheral vascular disease 26.0 CRP F2 PLAT SELP SERPINE1 VCAM1
18 arteries, anomalies of 24.7 CRP F2 ICAM1 MMP9 PLAT SELP
19 vascular disease 24.4 CRP F2 ICAM1 MMP9 PLAT SELP
20 fibrinolytic defect 10.9 PLAT SERPINE1
21 plasminogen activator inhibitor-1 deficiency 10.8 PLAT SERPINE1
22 argentine hemorrhagic fever 10.8 PLAT SERPINE1
23 central serous chorioretinopathy 10.8 PLAT SERPINE1
24 coronary restenosis 10.8 ITGA4 PLAT
25 livedoid vasculopathy 10.7 F2 SERPINE1
26 intracranial embolism 10.7 F2 PLAT
27 cryptogenic cirrhosis 10.7 F2 SERPINE1
28 toxicodendron dermatitis 10.6 ICAM1 SELL
29 amaurosis fugax 10.6 MMP9 SERPINE1
30 retinal artery occlusion 10.6 F2 SERPINE1
31 autoimmune inner ear disease 10.6 MMP9 TIMP1
32 marantic endocarditis 10.6 F2 PLAT
33 acute cor pulmonale 10.6 PLAT SERPINE1
34 diabetic foot ulcers 10.6 MMP9 TIMP1
35 plummer's disease 10.6 ICAM1 SELL
36 basilar artery occlusion 10.6 F2 PLAT
37 pediatric multiple sclerosis 10.6 ITGA4 MMP9
38 cryptogenic organizing pneumonia 10.5 MMP9 TIMP1
39 conjunctival nevus 10.5 MMP9 TIMP1
40 ischemic colitis 10.5 F2 MMP9
41 microcystic meningioma 10.5 MMP9 TIMP1
42 carotid artery thrombosis 10.5 PLAT SELP SERPINE1
43 disseminated intravascular coagulation 10.5 F2 PLAT SERPINE1
44 peliosis hepatis 10.5 F2 ITGA4 SELL
45 arthus reaction 10.4 ICAM1 SELL
46 conjunctivochalasis 10.4 MMP1 TIMP1
47 lymphocytic vasculitis 10.4 ICAM1 VCAM1
48 cortical thymoma 10.4 ICAM1 VCAM1
49 portal vein thrombosis 10.4 F2 SELP SERPINE1
50 antiphospholipid syndrome 10.4 F2 PLAT SELP

Comorbidity relations with Venous Insufficiency via Phenotypic Disease Network (PDN): (show all 23)


Acute Cystitis Aortic Valve Disease 1
Bronchitis Chronic Kidney Failure
Chronic Myocardial Ischemia Chronic Pulmonary Heart Disease
Decubitus Ulcer Deficiency Anemia
Familial Atrial Fibrillation Femoral Vein Thrombophlebitis
Generalized Atherosclerosis Heart Disease
Hypertension, Essential Hypothyroidism
Iron Deficiency Anemia Ischemic Heart Disease
Mitral Valve Disease Osteoporosis
Peripheral Vascular Disease Post-Thrombotic Syndrome
Protein-Energy Malnutrition Schizophreniform Disorder
Tinea Pedis

Graphical network of the top 20 diseases related to Venous Insufficiency:



Diseases related to Venous Insufficiency

Symptoms & Phenotypes for Venous Insufficiency

MGI Mouse Phenotypes related to Venous Insufficiency:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.23 PLAT ICAM1 SELL ITGA4 SELP MMP9
2 homeostasis/metabolism MP:0005376 10.15 PLAT ICAM1 SELL MMP1 SELP MMP9
3 hematopoietic system MP:0005397 10.14 PLAT ICAM1 SELL ITGA4 SELP MMP9
4 immune system MP:0005387 10.13 ICAM1 SELL ITGA4 SELP MMP1 MMP9
5 growth/size/body region MP:0005378 10.09 F2 PLAT ICAM1 SELL MMP9 SERPINE1
6 mortality/aging MP:0010768 9.85 F2 PLAT ICAM1 ITGA4 MMP9 SERPINE1
7 integument MP:0010771 9.8 F2 PLAT ICAM1 SELL MMP9 SERPINE1
8 neoplasm MP:0002006 9.43 ICAM1 SELL MMP1 MMP9 SERPINE1 TIMP1
9 respiratory system MP:0005388 9.17 F2 PLAT SELL SELP MMP9 TIMP1

Drugs & Therapeutics for Venous Insufficiency

Drugs for Venous Insufficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 129)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 4,Not Applicable 137-58-6 3676
2
Polidocanol Approved Phase 4,Phase 3 9002-92-0
3
Sodium Tetradecyl Sulfate Approved, Investigational Phase 4,Phase 2,Not Applicable 1191-50-0, 139-88-8 14492 5248
4
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
5
Racepinephrine Approved Phase 4 329-65-7 838
6
Rivaroxaban Approved Phase 4 366789-02-8
7
Glucosamine Approved, Investigational, Nutraceutical Phase 4,Early Phase 1 3416-24-8 439213
8
Serine Approved, Nutraceutical Phase 4 56-45-1 5951
9
Troxerutin Investigational Phase 4,Not Applicable 7085-55-4 5486699
10 Anesthetics Phase 4,Not Applicable
11 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
12 Anesthetics, Local Phase 4,Not Applicable
13 Anti-Arrhythmia Agents Phase 4,Not Applicable
14 Central Nervous System Depressants Phase 4,Not Applicable
15 Diuretics, Potassium Sparing Phase 4,Not Applicable
16 Peripheral Nervous System Agents Phase 4,Phase 2,Not Applicable
17 Sodium Channel Blockers Phase 4,Not Applicable
18 Anticoagulants Phase 4,Phase 3,Not Applicable
19 Heparinoids Phase 4
20 Salicylates Phase 4,Phase 1,Phase 2
21 Aminaftone Phase 4
22 Coagulants Phase 4,Phase 3,Not Applicable
23 Hemostatics Phase 4,Phase 3,Not Applicable
24 Anti-Inflammatory Agents Phase 4,Not Applicable
25 Fibrinolytic Agents Phase 4,Phase 3,Not Applicable
26 Adrenergic Agents Phase 4
27 Adrenergic Agonists Phase 4
28 Adrenergic alpha-Agonists Phase 4
29 Adrenergic beta-Agonists Phase 4
30 Anti-Asthmatic Agents Phase 4,Phase 2
31 Autonomic Agents Phase 4,Phase 2
32 Bronchodilator Agents Phase 4,Phase 2
33 Epinephryl borate Phase 4
34 Mydriatics Phase 4
35 Neurotransmitter Agents Phase 4,Phase 2
36 Respiratory System Agents Phase 4,Phase 2
37 Vasoconstrictor Agents Phase 4
38 Antithrombin III Phase 4
39 Antithrombins Phase 4
40 Factor Xa Inhibitors Phase 4
41 HIV Protease Inhibitors Phase 4
42
protease inhibitors Phase 4
43 Serine Proteinase Inhibitors Phase 4
44 Antimetabolites Phase 4
45 Glucuronyl glucosamine glycan sulfate Phase 4
46 Hypoglycemic Agents Phase 4
47 Hypolipidemic Agents Phase 4
48 Lipid Regulating Agents Phase 4
49 Calamus Nutraceutical Phase 4,Not Applicable
50
Coumarin Experimental, Nutraceutical Phase 4 91-64-5 323

Interventional clinical trials:

(show top 50) (show all 250)
# Name Status NCT ID Phase Drugs
1 Clinical Evaluation of the SNaP Wound Care System Unknown status NCT01113658 Phase 4
2 Clinical Non-inferiority Study Between Diosmin 600mg & Diosmin + Hesperidin in Symptomatic Chronic Venous Insufficiency Completed NCT03471910 Phase 4 Diosmin;Diosmin / Hesperidin
3 Efficacy and Safety of the Use of Venocur Triplex® in Patients With Chronic Venous Insufficiency Completed NCT00835822 Phase 4 Venocur Triplex®;placebo
4 Tolerability of Antistax® in Patients Suffering From Chronic Venous Insufficiency (CVI) Completed NCT02184234 Phase 4 Antistax film coated tablets
5 Efficacy and Safety of Coumarin and Troxerutin in the Symptomatic Treatment of Chronic Venous Insufficiency Completed NCT01848210 Phase 4 Coumarin/troxerutin;Placebo
6 Efficacy and Safety of Esarin Gel in Chronic Venous Insufficiency and Varicose Veins Completed NCT02346058 Phase 4 Esarin Gel
7 Iliac Vein Stenting in Advanced Chronic Venous Insufficiency Completed NCT02149212 Phase 4 Phlebotonic
8 Practicability of Gliding Aids for Medical Compression Stockings Completed NCT01432795 Phase 4
9 Radiofrequency Ablation vs Laser Ablation of the Incompetent Greater Saphenous Vein Completed NCT02236338 Phase 4
10 Radiofrequency Ablation vs. Laser Ablation of the Incompetent Small Saphenous Vein Completed NCT02248740 Phase 4
11 Neuromuscular Electrical Therapy in Venous Ulcers Completed NCT01372020 Phase 4
12 SocknLeg - a User Friendly Medical Compression Study of a Modified Application of a Medical Device Completed NCT02621632 Phase 4
13 The Fate Of Calf Perforators After Endovenous Laser Ablation Of Saphenous Veins Completed NCT01458795 Phase 4
14 A Pilot Trial of the Use of ReCell® Autologous Cell Harvesting Device for Venous Leg Ulcers Completed NCT01743053 Phase 4
15 Polidocanol Versus Glucose Treatment of Telangiectasia Trial Completed NCT02657252 Phase 4 Glucose;Polidocanol with Glucose
16 Study Protocol Comparing Polidocanol Versus Hypertonic Glucose for Treatment of Reticular Veins Completed NCT02054325 Phase 4 Polidocanol with Glucose;Glucose
17 ClosureFAST vs. Laser Ablation for the Treatment of GSV Disease: A Multicenter, Single-Blinded, Randomized Study. Completed NCT00509392 Phase 4
18 Wound Fluid Protease Levels During Use of Novel Wound Dressing Completed NCT01567150 Phase 4
19 OASIS Wound Matrix (Oasis) Mechanism of Action Completed NCT00570141 Phase 4
20 Laser Ablation Versus Mechanochemical Ablation Trial Recruiting NCT02627846 Phase 4 Lidocaine with 1:200,000 epinephrine solution;Lidocaine with 1:200,000 epinephrine solution;Sodium Bicarbonate;Sodium Tetradecyl Sulphate
21 Rivaroxaban With Diosmine in Long-term Treatment of DVT Recruiting NCT03413618 Phase 4 Rivaroxaban;Diosmin
22 Study of Foam Sclerotherapy Versus Ambulatory Phlebectomy Recruiting NCT03416413 Phase 4 Foam sclerotherapy
23 Study of Antiinflammatory Effects of Detralex (Daflon) Enrolling by invitation NCT01654016 Phase 4 Detralex
24 Prospective Evaluation of the QoL of Patients With PTS Who Receive Compression Therapy and Sulodexide Terminated NCT02512601 Phase 4 Sulodexide
25 Flexitouch Compression System for Venous Stasis Ulcer Terminated NCT00534937 Phase 4
26 RCT Comparing Standard Cannula Delivered FS, UGFS and ClariVein® in the Management of SVI Withdrawn NCT02010437 Phase 4 Sodium Tetradecyl Sulphate (STS)
27 Study to Evaluate the Efficacy and Tolerability of Venaflon Use in Reducing the Symptoms Caused by Chronic Venous Insufficiency When Compared With Daflon Unknown status NCT01477281 Phase 3 Daflon;Venaflon (Diosmin and Hesperidin)
28 Efficacy and Tolerability of the Use of Varicell Compared With Daflon Unknown status NCT01321619 Phase 3 Daflon;Varicell placebo
29 Comparative Efficacy of Two Preparations of the Association Diosmin (450 mg) + Hesperidin (50 mg) in the Treatment of Chronic Venous Insufficiency (CVI) Unknown status NCT01110512 Phase 3 Flavonid;Daflon
30 Safety and Efficacy Study of ICXP007 With Compression Bandaging for the Treatment of Non-Infected Venous Leg Ulcers Unknown status NCT00232973 Phase 3 ICXP007
31 Treatment Trial for Post-Thrombotic Syndrome Unknown status NCT00633971 Phase 3
32 Efficacy and Tolerability of Antistax® in Male and Female Patients Suffering From Chronic Venous Insufficiency Completed NCT02191254 Phase 3 Antistax®;Placebo
33 Assess the Efficacy and Tolerability of Antistax Film-coated Tablets in Patients With Chronic Venous Insufficiency Completed NCT00855179 Phase 3 Red vine leaf extract (AS 195);Placebo
34 Crenobalneotherapy in the Treatment of Chronic Venous Insufficiency Completed NCT01956318 Phase 3
35 Efficacy and Tolerability CVI (A 12-week, Double-blind, Randomised, Placebo-controlled, Multicentre Trial (CVI) Completed NCT00292435 Phase 3 Read vine leaf extract (AS 195)
36 The Influence of Compression Stockings on Skin's Barrier Function at Patients With Chronic Venous Disease Completed NCT00196443 Phase 2, Phase 3
37 THERMES ET VEINES: Spa for Prevention of Leg Ulcers Completed NCT00838500 Phase 3 Immediate spa treatment;Late spa treatment
38 Efficacy on Volume Reduction and Tolerance of Progressiv' Medical Compressive Therapy (MCT) V0322 BC in Patients With Chronic Venous Oedema Completed NCT01402921 Phase 3
39 Clinical Study of BNS003 on Swelling in Legs Due to Venous Reflux Completed NCT02211898 Phase 3 BNS003
40 ESGVS: Sclerotherapy With Lauromacrogol Completed NCT00348764 Phase 3 lauromacrogol
41 Evaluation of Long-Term Sequelae After Thrombophlebitis, i.e. Deep Venous Thrombosis of the Lower Extremities Completed NCT00628576 Phase 3 unfractionated heparin;Tinzaparin (Leo)
42 Polidocanol Endovenous Microfoam (PEM) Versus Vehicle for the Treatment of Saphenofemoral Junction (SFJ) Incompetence Completed NCT01231373 Phase 3 polidocanol injectable foam, 0.125%;polidocanol injectable foam, 0.5%;polidocanol injectable foam, 1.0%;Vehicle
43 Efficacy and Safety Study of Polidocanol Injectable Foam for the Treatment of Saphenofemoral Junction (SFJ) Incompetence Completed NCT01072877 Phase 3 Polidocanol injectable foam (PEM);Placebo Vehicle
44 Study Investigating the Safety and Efficacy of HP802-247 in the Treatment of Venous Leg Ulcers >12 cm2 to ≤ 36 cm2 Completed NCT01737762 Phase 3
45 Acute Venous Thrombosis: Thrombus Removal With Adjunctive Catheter-Directed Thrombolysis Completed NCT00790335 Phase 3 Recombinant tissue plasminogen activator (rt-PA)
46 Full-Leg vs Below-Knee Elastic Stockings for Prevention of the Post-Thrombotic Syndrome Completed NCT00426075 Phase 3
47 The SOX Trial: Compression Stockings to Prevent the Post-Thrombotic Syndrome Completed NCT00143598 Phase 3
48 Evaluation of a Venous-Return Assist Device (Venowave) to Treat Post-Thrombotic Syndrome: A Randomized Controlled Trial Completed NCT00182208 Phase 3
49 PRP ULCERAS: Clinical Trial Phase III Active, not recruiting NCT02213952 Phase 3 Platelet-Rich Plasma
50 Study to Assess the Efficacy and Safety of Endolex Forte VErsus Diosmin and Hesperidin in Reducing VeNous Insufficiency Not yet recruiting NCT02927483 Phase 3

Search NIH Clinical Center for Venous Insufficiency

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: venous insufficiency

Genetic Tests for Venous Insufficiency

Genetic tests related to Venous Insufficiency:

# Genetic test Affiliating Genes
1 Venous Insufficiency 29

Anatomical Context for Venous Insufficiency

MalaCards organs/tissues related to Venous Insufficiency:

41
Skin, Bone, Testes, Endothelial, Brain, Heart, Placenta

Publications for Venous Insufficiency

Articles related to Venous Insufficiency:

(show top 50) (show all 675)
# Title Authors Year
1
Retrograde administration of ultrasound-guided endovenous microfoam chemical ablation for the treatment of superficial venous insufficiency. ( 29909854 )
2018
2
Experience of Using Shear Wave Elastography Imaging in Superficial Venous Insufficiency of the Lower Extremity. ( 29634667 )
2018
3
Thermal and Nonthermal Endovenous Ablation Options for Treatment of Superficial Venous Insufficiency. ( 29502779 )
2018
4
The influence of exercise on ulcer healing in patients with chronic venous insufficiency. ( 29368880 )
2018
5
A retrospective study of a new n-butyl-2-cyanoacrylate glue ablation catheter incorporated with application guiding light for the treatment of venous insufficiency: Twelve-month results. ( 29642798 )
2018
6
Systematic review and meta-analysis of endovascular and surgical revascularization for patients with chronic lower extremity venous insufficiency and varicose veins. ( 29421005 )
2018
7
Chronic Cerebro-Spinal Venous Insufficiency in Multiple Sclerosis: Is It the End? ( 29629362 )
2018
8
Endovenous Thermal Ablation of Recurrent Varicose Veins due to Residual Great Saphenous Venous Insufficiency After Saphenous Venous Surgery: A Comparative Study. ( 29781902 )
2018
9
Varicose Veins and Lower Extremity Venous Insufficiency. ( 29628617 )
2018
10
US budget impact of increased payer adoption of the Flexitouch advanced pneumatic compression device in lymphedema patients with advanced chronic venous insufficiency and multiple infections. ( 29975564 )
2018
11
Plasma concentration of selected biochemical markers of endothelial dysfunction in women with various severity of chronic venous insufficiency (CVI)-A pilot study. ( 29377939 )
2018
12
Efficacy of subcutaneous lidocaine injection in venous insufficiency: a prospective, randomized, controlled study, and new treatment protocol. ( 29950758 )
2018
13
Iliac vein stenosis is an underdiagnosed cause of pelvic venous insufficiency. ( 29292119 )
2018
14
Suppressed networks of inflammatory mediators characterize chronic venous insufficiency. ( 29439934 )
2018
15
Venous insufficiency: Differences in the content of trace elements. A preliminary report. ( 29616754 )
2018
16
Placentas from women with pregnancy-associated venous insufficiency show villi damage with evidence of hypoxic cellular stress. ( 29626597 )
2018
17
Ultrasound-guided foam sclerotherapy for severe chronic venous insufficiency. ( 29019582 )
2017
18
Case of chronic venous insufficiency-associated Kaposi's sarcoma in a Japanese patient. ( 28771851 )
2017
19
Genetic predisposition for chronic venous insufficiency in several genes for matrix metalloproteinases (MMP-2, MMP-9, MMP-12) and their inhibitor TIMP-2. ( 28662285 )
2017
20
Increased inflammatory status in chronic venous insufficiency patients. ( 28592220 )
2017
21
Advanced Chronic Venous Insufficiency. ( 28024458 )
2017
22
Quantification of early cutaneous manifestations of chronic venous insufficiency by automated analysis of photographic images: Feasibility and technical considerations. ( 28403688 )
2017
23
Changing Medicare Utilization of Minimally Invasive Procedures for the Treatment of Chronic Venous Insufficiency. ( 28396193 )
2017
24
Chronic Venous Insufficiency: a Frequently Underdiagnosed and Undertreated Pathology. ( 28878840 )
2017
25
A failure of preoperative duplex imaging to diagnose a lower extremity venous aneurysm in a patient with severe chronic venous insufficiency. ( 28255445 )
2017
26
Treatment of incompetent perforators in recurrent venous insufficiency with adhesive embolization and sclerotherapy. ( 28956508 )
2017
27
TGF-I^1 in Vascular Wall Pathology: Unraveling Chronic Venous Insufficiency Pathophysiology. ( 29186866 )
2017
28
A Systematic Review and Meta-analysis of Exercise Intervention for the Treatment of Calf Muscle Pump Impairment in Individuals with Chronic Venous Insufficiency. ( 28873064 )
2017
29
Venous ultrasonography findings and clinical correlations in 104 Thai patients with chronic venous insufficiency of the legs. ( 28503700 )
2017
30
Chronic venous insufficiency - a review of pathophysiology, diagnosis, and treatment. ( 28485865 )
2017
31
Remodelling of collagen fibres in the placentas of women with venous insufficiency during pregnancy. ( 29171654 )
2017
32
Differentiation of functional venous insufficiency and leg lymphedema complicated by functional venous insufficiency using subcutaneous tissue ultrasonography. ( 27987622 )
2017
33
Efficiency of a New Combined Laser Therapy in Patients With Trophic Ulcers of Lower Extremities and Chronic Venous Insufficiency. ( 29123633 )
2017
34
Contact Sensitization in Patients With Lower Leg Dermatitis, Chronic Venous Insufficiency, and/or Chronic Leg Ulcer: Assessment of the Clinical Relevance of Contact Allergens. ( 29199962 )
2017
35
The relationship between chronic venous insufficiency and diabetes mellitus. ( 28124879 )
2017
36
Primary pulmonary arterial hypertension with preserved right ventricular function leads to lower extremity venous insufficiency. ( 28835185 )
2017
37
Chronic Venous Insufficiency: Transforming Growth Factor-I^ Isoforms and Soluble Endoglin Concentration in Different States of Wound Healing. ( 29065449 )
2017
38
Echocolor Doppler morpho-functional study of the jugulo-subclavian confluence in chronic cerebro-spinal venous insufficiency and multiple sclerosis patients. ( 29339583 )
2017
39
Preliminary results of severe venous insufficiency treatment with thermal ablation of the great saphenous vein by endovascular technique with laser diode 980nm developed in Brazil, associated with sclerotherapy with polidocanol. ( 28767808 )
2017
40
Failure of the vascular hypothesis of multiple sclerosis in a rat model of chronic cerebrospinal venous insufficiency. ( 28430292 )
2017
41
Evaluation of inflammatory cell biomarkers in chronic venous insufficiency. ( 28379059 )
2017
42
Cultural adaptation and validation of the Swedish VEINES-QOL/Sym in patients with venous insufficiency. ( 28954585 )
2017
43
Chronic Venous Insufficiency: Novel Management Strategies for an Under-diagnosed Disease Process. ( 28459920 )
2017
44
Mechanochemical Ablation for Treatment of Truncal Venous Insufficiency: A Review of the Current Literature. ( 28811080 )
2017
45
The calendar of cytokines: Seasonal variation of circulating cytokines in chronic venous insufficiency. ( 28959442 )
2017
46
Nocturnal leg symptoms are not associated with specific patterns of superficial venous insufficiency. ( 28854778 )
2017
47
Centralized and Local Color Doppler Ultrasound Reading Agreement for Diagnosis of the Chronic Cerebrospinal Venous Insufficiency in Patients with Multiple Sclerosis. ( 28721810 )
2017
48
Venous Insufficiency ( 28613694 )
2017
49
Management of Varicose Veins and Chronic Venous Insufficiency in a Comparative Registry with Nine Venoactive Products in Comparison with Stockings. ( 28804235 )
2017
50
Effects of isokinetic calf muscle exercise program on muscle strength and venous function in patients with chronic venous insufficiency. ( 28954574 )
2017

Variations for Venous Insufficiency

Expression for Venous Insufficiency

Search GEO for disease gene expression data for Venous Insufficiency.

Pathways for Venous Insufficiency

Pathways related to Venous Insufficiency according to GeneCards Suite gene sharing:

(show all 35)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.88 CRP ICAM1 ITGA4 MMP1 MMP9 SELL
2
Show member pathways
13.27 F2 ICAM1 ITGA4 MMP1 MMP9 SERPINE1
3
Show member pathways
13.22 ICAM1 MMP1 MMP9 TIMP1 VCAM1 VWF
4
Show member pathways
12.89 F2 ITGA4 MMP1 PLAT SELL SELP
5
Show member pathways
12.53 ICAM1 ITGA4 MMP9 VCAM1
6
Show member pathways
12.46 ICAM1 ITGA4 MMP1 MMP9 SERPINE1 TIMP1
7
Show member pathways
12.23 CRP F2 ICAM1 PLAT SERPINE1
8
Show member pathways
12.11 F2 ITGA4 MMP1 SELL SELP
9
Show member pathways
12.09 MMP1 SERPINE1 TIMP1
10
Show member pathways
12.07 F2 PLAT SERPINE1 VWF
11
Show member pathways
12.02 ICAM1 ITGA4 VCAM1 VWF
12 11.98 F2 PLAT SERPINE1 VWF
13 11.97 ICAM1 MMP9 PLAT VCAM1
14 11.96 ICAM1 ITGA4 SELL SELP VCAM1
15 11.94 ICAM1 ITGA4 SELL VCAM1
16 11.89 ICAM1 MMP9 SELP
17 11.86 ICAM1 ITGA4 MMP9 SERPINE1 VCAM1
18 11.83 ICAM1 MMP9 VCAM1
19 11.78 ICAM1 SERPINE1 VCAM1
20
Show member pathways
11.78 MMP1 MMP9 TIMP1
21 11.78 ICAM1 MMP1 MMP9 TIMP1 VCAM1
22 11.72 MMP9 TIMP1 VWF
23
Show member pathways
11.58 ICAM1 MMP1 MMP9 VCAM1
24 11.45 ICAM1 SELP VCAM1
25 11.42 ICAM1 MMP9 PLAT SELP
26 11.4 ICAM1 ITGA4 VCAM1
27 11.32 MMP1 MMP9 SELL
28 11.03 MMP9 PLAT
29 10.98 F2 MMP1
30 10.93 MMP1 TIMP1
31 10.88 MMP1 MMP9
32 10.85 ICAM1 VCAM1
33 10.81 MMP1 MMP9 PLAT SERPINE1 TIMP1
34 10.73 PLAT SERPINE1
35 10.65 F2 ICAM1 MMP9 TIMP1

GO Terms for Venous Insufficiency

Cellular components related to Venous Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.97 CRP F2 MMP1 MMP9 PLAT SERPINE1
2 extracellular exosome GO:0070062 9.85 CRP F2 ICAM1 ITGA4 MMP9 PLAT
3 cell surface GO:0009986 9.8 ICAM1 ITGA4 PLAT SELL VCAM1
4 external side of plasma membrane GO:0009897 9.65 F2 ICAM1 SELL SELP VCAM1
5 extracellular space GO:0005615 9.61 CRP F2 ICAM1 MMP9 PLAT SELP
6 platelet alpha granule lumen GO:0031093 9.5 SERPINE1 TIMP1 VWF
7 extracellular matrix GO:0031012 9.17 ICAM1 MMP1 MMP9 PLAT SERPINE1 TIMP1

Biological processes related to Venous Insufficiency according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.85 ICAM1 ITGA4 SELL SELP VCAM1 VWF
2 regulation of immune response GO:0050776 9.8 ICAM1 ITGA4 SELL VCAM1
3 cytokine-mediated signaling pathway GO:0019221 9.8 ICAM1 MMP1 MMP9 TIMP1 VCAM1
4 response to hypoxia GO:0001666 9.76 ICAM1 PLAT VCAM1
5 platelet degranulation GO:0002576 9.73 SELP SERPINE1 TIMP1 VWF
6 extracellular matrix disassembly GO:0022617 9.69 MMP1 MMP9 TIMP1
7 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.63 ICAM1 SELP VCAM1
8 extracellular matrix organization GO:0030198 9.63 ICAM1 ITGA4 MMP9 SERPINE1 VCAM1 VWF
9 negative regulation of proteolysis GO:0045861 9.58 F2 PLAT
10 calcium-mediated signaling using intracellular calcium source GO:0035584 9.57 SELP VCAM1
11 blood coagulation, intrinsic pathway GO:0007597 9.56 F2 VWF
12 leukocyte cell-cell adhesion GO:0007159 9.56 ICAM1 ITGA4 SELP VCAM1
13 positive regulation of leukocyte migration GO:0002687 9.55 ITGA4 SELP
14 positive regulation of blood coagulation GO:0030194 9.54 F2 SERPINE1
15 negative regulation of fibrinolysis GO:0051918 9.52 F2 SERPINE1
16 fibrinolysis GO:0042730 9.5 F2 PLAT SERPINE1
17 membrane to membrane docking GO:0022614 9.48 ICAM1 VCAM1
18 leukocyte tethering or rolling GO:0050901 9.26 ITGA4 SELL SELP VCAM1
19 leukocyte migration GO:0050900 9.17 F2 ICAM1 ITGA4 MMP1 MMP9 SELL

Molecular functions related to Venous Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 9.58 F2 SELL SELP
2 serine-type endopeptidase activity GO:0004252 9.56 F2 MMP1 MMP9 PLAT
3 integrin binding GO:0005178 9.54 ICAM1 VCAM1 VWF
4 cell adhesion molecule binding GO:0050839 9.33 ITGA4 SELL VCAM1
5 oligosaccharide binding GO:0070492 9.32 SELL SELP
6 glycosphingolipid binding GO:0043208 8.96 SELL SELP
7 protease binding GO:0002020 8.92 SELL SERPINE1 TIMP1 VWF

Sources for Venous Insufficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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