MCID: VNS003
MIFTS: 55

Venous Insufficiency

Categories: Blood diseases, Cardiovascular diseases

Aliases & Classifications for Venous Insufficiency

MalaCards integrated aliases for Venous Insufficiency:

Name: Venous Insufficiency 12 29 43 15 71 32
Peripheral Venous Insufficiency 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10128
ICD9CM 34 459.81
MeSH 43 D014689
NCIt 49 C127822
SNOMED-CT 67 20696009
ICD10 32 I87.2
UMLS 71 C0042485

Summaries for Venous Insufficiency

Disease Ontology : 12 A vein disease that is characterized by impaired flow of blood through the veins.

MalaCards based summary : Venous Insufficiency, also known as peripheral venous insufficiency, is related to lipodermatosclerosis and post-thrombotic syndrome. An important gene associated with Venous Insufficiency is PLAT (Plasminogen Activator, Tissue Type), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Hesperidin and Epinephrine have been mentioned in the context of this disorder. Affiliated tissues include skin, heart and testes, and related phenotypes are cardiovascular system and homeostasis/metabolism

Related Diseases for Venous Insufficiency

Diseases in the Venous Insufficiency family:

Chronic Venous Insufficiency

Diseases related to Venous Insufficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 470)
# Related Disease Score Top Affiliating Genes
1 lipodermatosclerosis 32.7 VEGFA PLAT MMP1
2 post-thrombotic syndrome 31.9 VCAM1 SERPINE1 PLAT ICAM1 F5 F2
3 chronic venous insufficiency 31.2 VEGFA VCAM1 TIMP1 SERPINE1 SELP SELL
4 thrombophilia due to thrombin defect 30.5 SERPINE1 PLAT MTHFR F5 F2
5 relapsing-remitting multiple sclerosis 30.5 TIMP1 MMP9 ITGA4 ICAM1
6 chronic ulcer of skin 30.4 VEGFA MMP1 CRP
7 hemorrhoid 30.4 MMP9 F2 CRP
8 thoracic outlet syndrome 30.1 PLAT F2
9 aspiration pneumonia 30.0 ITGAM F2 CRP
10 telangiectasis 29.9 VEGFA NDP ELN
11 papilledema 29.9 VEGFA F2 CRP
12 purpura 29.8 VWF SELP F2 CRP
13 buerger disease 29.7 SERPINE1 PLAU MTHFR F2
14 pyoderma 29.7 MMP9 MMP1 CRP
15 arteriosclerosis obliterans 29.6 VCAM1 SELP MMP9 ICAM1
16 microvascular complications of diabetes 5 29.6 VEGFA VCAM1 SERPINE1 ICAM1
17 brain edema 29.6 VEGFA PLAT MMP9 CRP
18 endocarditis 29.6 VCAM1 SERPINE1 PLAT F2 CRP
19 skin disease 29.6 SELL MMP1 ICAM1 ELN CRP
20 intracranial hypertension 29.5 SERPINE1 MTHFR F5 F2
21 sudden sensorineural hearing loss 29.5 MTHFR F5 F2
22 hemangioma 29.5 VWF VEGFA MMP9 F2
23 primary progressive multiple sclerosis 29.5 VCAM1 TIMP1 SELL MMP9 ITGA4 ICAM1
24 osteoarthritis 29.4 TIMP1 MMP9 MMP1 CRP
25 hypothyroidism 29.4 VWF VEGFA SERPINE1 F2 CRP
26 portal hypertension 29.3 VWF VEGFA SERPINE1 F2 ELN
27 thrombophlebitis 29.3 VWF SERPINE1 SELP PLAT MTHFR F5
28 proteasome-associated autoinflammatory syndrome 1 29.3 VCAM1 SELP SELL MMP9 ICAM1 CRP
29 sleep apnea 29.3 VEGFA VCAM1 SELP ICAM1 CRP
30 dermatitis, atopic 29.3 VCAM1 TIMP1 SELP SELL ITGAM ICAM1
31 amaurosis fugax 29.3 SERPINE1 MTHFR MMP9 F5
32 vasculitis 29.2 VWF VCAM1 SELP SELL ITGAM ITGA4
33 lung disease 29.1 VEGFA MMP9 ICAM1 ELN CRP
34 pulmonary embolism 29.1 VWF SERPINE1 PLAU PLAT MTHFR F5
35 thrombophilia 29.0 VWF SERPINE1 SELP PLAT MTHFR F5
36 hydronephrosis 29.0 VWF VEGFA TIMP1 MMP9 ICAM1 CRP
37 peripheral artery disease 29.0 VWF VEGFA VCAM1 SELP ICAM1 CRP
38 retinal vein occlusion 29.0 VEGFA SERPINE1 MTHFR F5 F2
39 body mass index quantitative trait locus 11 28.9 VEGFA VCAM1 SERPINE1 SELL ICAM1 CRP
40 pulmonary disease, chronic obstructive 28.9 TIMP1 MMP9 MMP1 ITGAM ELN CRP
41 tetralogy of fallot 28.8 VEGFA MTHFR MMP9 ELN CRP
42 coronary heart disease 1 28.8 VWF VCAM1 SERPINE1 SELP PLAT MTHFR
43 synovitis 28.7 VEGFA VCAM1 MMP9 MMP1 ICAM1 CRP
44 varicose veins 28.7 VWF VEGFA TIMP1 PLAT MTHFR MMP9
45 central retinal vein occlusion 28.7 VWF VEGFA PLAT MTHFR F5 F2
46 thrombosis 28.7 VWF VCAM1 SERPINE1 SELP PLAU PLAT
47 vein disease 28.5 VWF VEGFA SERPINE1 PLAT MTHFR ICAM1
48 arteriosclerosis 28.5 VCAM1 TIMP1 SERPINE1 SELP MMP9 ICAM1
49 peripheral vascular disease 28.5 VWF VEGFA VCAM1 TIMP1 SERPINE1 SELP
50 retinal vascular disease 28.4 VEGFA VCAM1 NDP MTHFR ICAM1 CRP

Comorbidity relations with Venous Insufficiency via Phenotypic Disease Network (PDN): (show all 20)


Acute Cystitis Aortic Valve Disease 1
Bronchitis Chronic Pulmonary Heart Disease
Decubitus Ulcer Deficiency Anemia
Familial Atrial Fibrillation Femoral Vein Thrombophlebitis
Generalized Atherosclerosis Heart Disease
Hypertension, Essential Hypothyroidism
Iron Deficiency Anemia Mitral Valve Disease
Osteoporosis Peripheral Vascular Disease
Post-Thrombotic Syndrome Protein-Energy Malnutrition
Schizophreniform Disorder Tinea Pedis

Graphical network of the top 20 diseases related to Venous Insufficiency:



Diseases related to Venous Insufficiency

Symptoms & Phenotypes for Venous Insufficiency

MGI Mouse Phenotypes related to Venous Insufficiency:

45 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.4 CRP F2 F5 ICAM1 ITGA4 MMP9
2 homeostasis/metabolism MP:0005376 10.33 CRP F2 F5 ICAM1 ITGAM MMP1
3 hematopoietic system MP:0005397 10.28 F2 ICAM1 ITGA4 ITGAM MMP9 PLAT
4 growth/size/body region MP:0005378 10.27 F2 F5 ICAM1 MMP9 MTHFR PLAT
5 immune system MP:0005387 10.27 CRP F2 ICAM1 ITGA4 ITGAM MMP1
6 cellular MP:0005384 10.22 ICAM1 ITGA4 ITGAM MMP9 PLAT PLAU
7 mortality/aging MP:0010768 10.1 F2 F5 ICAM1 ITGA4 MMP9 MTHFR
8 integument MP:0010771 10.06 F2 F5 ICAM1 MMP9 MTHFR PLAT
9 neoplasm MP:0002006 9.76 ICAM1 MMP1 MMP9 PLAU SELL SERPINE1
10 nervous system MP:0003631 9.73 F2 F5 ICAM1 ITGAM MMP9 MTHFR
11 respiratory system MP:0005388 9.28 F2 MMP9 PLAT PLAU SELL SELP

Drugs & Therapeutics for Venous Insufficiency

Drugs for Venous Insufficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 156)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hesperidin Approved, Investigational Phase 4 520-26-3 53477767
2
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
3
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
4
Racepinephrine Approved Phase 4 329-65-7 838
5
Glucosamine Approved, Investigational Phase 4 3416-24-8 439213
6
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
7
Coumarin Experimental Phase 4 91-64-5 323
8
Troxerutin Investigational Phase 4 7085-55-4 5486699
9 Heparinoids Phase 4
10 Aminaftone Phase 4
11 Calcium, Dietary Phase 4
12 Anticholesteremic Agents Phase 4
13 Rosuvastatin Calcium Phase 4 147098-20-2
14 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
15 Central Nervous System Depressants Phase 4
16 Anesthetics, Local Phase 4
17 Neurotransmitter Agents Phase 4
18 Anti-Arrhythmia Agents Phase 4
19 Adrenergic Agents Phase 4
20 Sympathomimetics Phase 4
21 Epinephryl borate Phase 4
22 Adrenergic Agonists Phase 4
23 Anti-Asthmatic Agents Phase 4
24 Vasoconstrictor Agents Phase 4
25 Sodium Channel Blockers Phase 4
26 Adrenergic beta-Agonists Phase 4
27 Respiratory System Agents Phase 4
28 Autonomic Agents Phase 4
29 Bronchodilator Agents Phase 4
30 Mydriatics Phase 4
31 Diuretics, Potassium Sparing Phase 4
32 Anticoagulants Phase 4
33 Glucuronyl glucosamine glycan sulfate Phase 4
34 Fibrinolytic Agents Phase 4
35 Hypolipidemic Agents Phase 4
36 Lipid Regulating Agents Phase 4
37 Antimetabolites Phase 4
38 Hypoglycemic Agents Phase 4
39
carbamide peroxide Approved Phase 2, Phase 3 124-43-6
40
Heparin Approved, Investigational Phase 3 9005-49-6 772 46507594
41
tannic acid Approved Phase 3 1401-55-4
42
Benzocaine Approved, Investigational Phase 3 1994-09-7, 94-09-7 2337
43
Dalteparin Approved Phase 3 9005-49-6
44
Tinzaparin Approved Phase 3 9041-08-1, 9005-49-6 25244225
45
Becaplermin Approved, Investigational Phase 3 165101-51-9
46
Methylprednisolone Approved, Vet_approved Phase 2, Phase 3 83-43-2 6741
47
Methylprednisolone hemisuccinate Approved Phase 2, Phase 3 2921-57-5
48
Prednisolone Approved, Vet_approved Phase 2, Phase 3 50-24-8 5755
49 Prednisolone acetate Approved, Vet_approved Phase 2, Phase 3 52-21-1
50
Prednisolone phosphate Approved, Vet_approved Phase 2, Phase 3 302-25-0

Interventional clinical trials:

(show top 50) (show all 241)
# Name Status NCT ID Phase Drugs
1 A 6-week, Open, Multicentre Safety Trial to Evaluate the Tolerability Profile of Antistax® Film Coated Tablets (Extr. Vitis Viniferae Siccum), 360 mg/Day Per os, in Male and Female Patients Suffering From Chronic Venous Insufficiency Completed NCT02184234 Phase 4 Antistax film coated tablets
2 Evaluate the Efficacy and Safety of Esarin Gel in the Treatment of Chronic Venous Insufficiency or Varicose Vein Combine With Superficial Vein Thrombophlebitis in Outpatient Completed NCT02346058 Phase 4 Esarin Gel
3 The Fate Of Calf Perforators After Endovenous Laser Ablation Of Saphenous Veins Completed NCT01458795 Phase 4
4 Multicenter, Prospective, Randomized, Double-Blind Study to Assess the Therapeutic Efficacy and Safety of the Use of Venocur Triplex® in Patients With Chronic Venous Insufficiency Completed NCT00835822 Phase 4 Venocur Triplex®;placebo
5 Gliding Aids for Medical Compression Stockings - Practicability in Elderly Patients With Chronic Venous Insufficiency Completed NCT01432795 Phase 4
6 Evaluation of Efficacy and Safety of the Fixed-dose Combination of Coumarin and Troxerutin (Venalot®) Versus Placebo in the Symptomatic Treatment of Chronic Venous Insufficiency - VENACT Completed NCT01848210 Phase 4 Coumarin/troxerutin;Placebo
7 Randomized Double-blind Trial Between Clinical and Endovascular Treatment in Patients With Advanced Chronic Venous Insufficiency and Iliac Venous Obstruction Completed NCT02149212 Phase 4 Phlebotonic
8 Clinical Non-inferiority Study Between Diosmin 600 mg Tablets and Diosmin 900 mg + Hesperidin 100 mg Tablets in Symptomatic Chronic Venous Insufficiency After 6 Months of Treatment: Single-blind, Randomized, Parallel Group Study Completed NCT03471910 Phase 4 Diosmin;Diosmin / Hesperidin
9 SocknLeg - a User Friendly Medical Compression Study of a Modified Application of a Medical Device Completed NCT02621632 Phase 4
10 The Effect of Neuromuscular Electrical Therapy on Pain in Patients With Venous Ulcers: a Controlled Clinical Trial Completed NCT01372020 Phase 4
11 Radiofrequency Ablation vs Laser Ablation of the Incompetent Greater Saphenous Vein: A Prospective Randomized Trial Completed NCT02236338 Phase 4
12 A Pilot Trial of the Use of ReCell® Autologous Cell Harvesting Device for Venous Leg Ulcers Completed NCT01743053 Phase 4
13 Study of Antiinflammatory Effects of Detralex (Daflon) in Patients With Chronic Venous Disease Completed NCT01654016 Phase 4 Detralex
14 A Randomized Triple-blind Study Protocol Comparing Polidocanol Versus Hypertonic Glucose for Sclerotherapy in Treatment of Reticular Veins at the Lower Limbs. Completed NCT02054325 Phase 4 Polidocanol with Glucose;Glucose
15 Polidocanol Versus Glucose For Sclerotherapy Treatment Of Telangiectasia Of The Lower Limbs: Protocol For A Randomized, Controlled Clinical Trial Completed NCT02657252 Phase 4 Glucose;Polidocanol with Glucose
16 Role of Statin in Venous Dysfunction in Patients With Venous Thromboembolism Event Recruiting NCT03988101 Phase 4 Rosuvastatin 20mg;Control
17 The Efficacy of Rivaroxaban With Diosmine in the Long-term Treatment of Acute Proximal Deep Vein Thrombosis Active, not recruiting NCT03413618 Phase 4 Rivaroxaban;Diosmin
18 A Randomised Clinical Trial Comparing Endovenous Laser Ablation and Mechanochemical Ablation (ClariVein®) in the Management of Superficial Venous Insufficiency Active, not recruiting NCT02627846 Phase 4 Lidocaine with 1:200,000 epinephrine solution;Lidocaine with 1:200,000 epinephrine solution;Sodium Bicarbonate;Sodium Tetradecyl Sulphate
19 Radiofrequency Ablation vs. Laser Ablation of the Incompetent Small Saphenous Vein: A Prospective Randomized Trial Terminated NCT02248740 Phase 4
20 Prospective Evaluation of the Quality of Life of Patients With Post-thrombotic Syndrome Who Receive Compression Therapy and Sulodexide — SQUARES Study Terminated NCT02512601 Phase 4 Sulodexide
21 A Randomized Trial of the Flexitouch Compression System as an Adjunctive Treatment for Venous Stasis Ulcer Terminated NCT00534937 Phase 4
22 A Randomised Clinical Trial Comparing Standard Cannula Delivered Foam Sclerotherapy, Catheter Directed Foam Sclerotherapy and ClariVein® Mechanochemical Ablation in the Management of Superficial Venous Insufficiency. Withdrawn NCT02010437 Phase 4 Sodium Tetradecyl Sulphate (STS)
23 A Clinical Multicenter, Phase III, Prospective, Randomized, Double-blind, Comparative Study to Evaluate the Efficacy and Tolerability of Venaflon Use in Reducing the Symptoms Caused by Chronic Venous Insufficiency When Compared With Daflon Unknown status NCT01477281 Phase 3 Daflon;Venaflon (Diosmin and Hesperidin)
24 Study Clinical, Multicenter,Phase III,Prospective,Randomized,Comparative Double Blind/Double-dummy to Assess the Efficacy and Tolerability of the Use of Varicell in Reducing the Symptoms Caused by Chronic Venous Insufficiency and Hemorrhoidal Syndrome When Compared With Daflon Unknown status NCT01321619 Phase 3 Daflon;Varicell placebo
25 Comparative Efficacy of Two Preparations of the Association Diosmin (450 mg) + Hesperidin (50 mg) in the Treatment of Chronic Venous Insufficiency (CVI) Unknown status NCT01110512 Phase 3 Flavonid;Daflon
26 A Comparative Study to Assess the Efficacy and Safety of Endolex Forte vs Diosmin and Hesperidin in Reducing the symptomatoLogy of Patients With ChronIc VeNous Insufficiency Between Functional Classes CEAP 1-4, During a Period of 6 Months Unknown status NCT02927483 Phase 3
27 A Prospective, Multi-Centre, Double Blind, Randomized, Placebo Controlled Trial to Evaluate the Safety and Efficacy of ICXP007 in a Phase III Trial With Four-Layer Therapeutic Compression, for the Treatment of Non-Infected Skin Leg Ulcers, Due to Venous-Insufficiency Unknown status NCT00232973 Phase 3 ICXP007
28 Efficacy of Autologous Platelet-Rich Plasma in the Treatment of Vascular Ulcers in Primary Care: Clinical Trial Phase III Unknown status NCT02213952 Phase 3 Platelet-Rich Plasma
29 Randomized Single Center Comparative Study of the Treatment of Insufficient Greater Saphenous Vein: Surgery vs Ultrasound Guided Sclerotherapy With Foam and Endovenous Laser Therapy Unknown status NCT00529672 Phase 3
30 A 12-week, Double-blind, Randomised, Placebo-controlled, Multicentre Trial to Evaluate Efficacy and Tolerability of Antistax® Film Coated Tablets, 360 mg/Day Orally, in Male and Female Patients Suffering From Chronic Venous Insufficiency Completed NCT02191254 Phase 3 Antistax®;Placebo
31 A 12-week, Double-blind, Randomised, Placebo-controlled, Multicentre Trial to Evaluate Efficacy and Tolerability of Antistax Film-coated Tablets, 360 mg/Day Orally, in Male and Female Patients Suffering From Chronic Venous Insufficiency. Completed NCT00292435 Phase 3 Read vine leaf extract (AS 195)
32 Prospective, Randomized and Explorative Controlled Study About Influences of Compression Stockings on Skin's Barrier Function at Patients With Chronic Venous Insufficiency Completed NCT00196443 Phase 2, Phase 3
33 A 12-week, Double-blind, Randomised, Placebo-controlled, Multicentre Trial to Evaluate Efficacy and Tolerability of Antistax® Film Coated Tablets, 720 mg/Day Orally, in Male and Female Patients Suffering From Chronic Venous Insufficiency Completed NCT00855179 Phase 3 Red vine leaf extract (AS 195);Placebo
34 Clinical Study of BNS003 on Swelling Due to Disorder of Leg Venous Reflux Completed NCT02211898 Phase 3 BNS003
35 Evaluation of the Efficacy of Spa Treatment for Prevention of Leg Ulcers in Advanced Chronic Venous Insufficiency. Completed NCT00838500 Phase 3 Immediate spa treatment;Late spa treatment
36 Crenobalneotherapy in the Treatment of Chronic Venous Insufficiency. A Randomized Clinical Trial. Completed NCT01956318 Phase 3
37 Efficacy on Volume Reduction and Tolerance of Progressiv' Medical Compressive Therapy (MCT) V0322 BC in Patients With Chronic Venous Oedema. International, Multicentric, Randomised, Controlled, Double Blind Study, in Two Parallel Groups v0322 bc Versus Placebo Completed NCT01402921 Phase 3
38 Treatment of Greater Saphenous Vein (GSV) Insufficiency Using Echo-Guided Sclerotherapy With Lauromacrogol 400 Foam –Comparative Study of 3% Versus 1% Concentration. Completed NCT00348764 Phase 3 lauromacrogol
39 A Phase 3 Randomized, Double Blind, Vehicle Controlled Study Investigating the Safety and Efficacy of HP802-247 in the Treatment of Venous Leg Ulcers >12 cm2 to ≤ 36 cm2 Completed NCT01737762 Phase 3
40 Deep Venous Thrombosis. Long-Term Results After Treatment With Either Low-Molecular -Weight Heparin or Unfractionated Heparin. Examinations of the Venous System. Completed NCT00628576 Phase 3 unfractionated heparin;Tinzaparin (Leo)
41 Double Blind Randomized Controlled Trial of Recombinant Human Platelet Derived Growth Factor-BB Gel (Regranex Gel®) Versus Hydrogel (Duoderm Hydrogel®) for Healing of MARTORELL's Hypertensive Leg Ulcers. ERAN Trial. Completed NCT00970697 Phase 3 becaplermin gel;Duoderm Hydrogel™
42 Zoledronic Acid or Methylprednisolone in the Management of Active Charcot's Neuroarthropathy of Foot in Patients With Diabetes Mellitus: A Randomized, Double-blind, Placebo Controlled Trial Completed NCT03289338 Phase 2, Phase 3 Zoledronic Acid;Methylprednisolone;Placebos
43 Double Blind, Randomized, Placebo Controlled Clinical Trial for the Treatment of Diabetic Foot Ulcers, Using a Nitric Oxide Releasing Patch: PATHON Completed NCT00428727 Phase 3 Controlled nitric oxide releasing patch;placebo patch
44 The MUFFIN-PTS Trial: Micronized Purified Flavonoid Fraction for the Treatment of Post-Thrombotic Syndrome Not yet recruiting NCT03833024 Phase 3 Micronized Purified Flavonoid Fraction;Placebo
45 A Phase 3 Randomized Safety and Efficacy Trial of HP802-247 in the Treatment of Chronic Venous Leg Ulcers (EU) Terminated NCT01853384 Phase 3
46 Clinical Evaluation of the Safety and Effectiveness of Topical Autologous Platelet Gel (APG) for the Treatment of Lower Extremity Chronic Venous Insufficiency Ulcers. A Multicenter, Randomized, Controlled Clinical Trial Withdrawn NCT00273234 Phase 3
47 A Prospective, Randomized, Controlled, Multi-Center, Double Blind Study of ClariVein RES for Treatment of Venous Insufficiency Associated With Incompetent Saphenous Veins Due to Superficial Venous Reflux Unknown status NCT03311269 Phase 2 Sodium Tetradecyl Sulfate 1% Injection;Sodium Tetradecyl Sulfate 3% Injection
48 Endovenous Treatment of the Saphenous Vein With Biolitec 1470nm Laser Versus Vnus Closure Fast Unknown status NCT01972633 Phase 1, Phase 2
49 Phase 1 and 2 Study on the Efficacy and Side Effects of Olive Oil and Omega 3 Local Treatment in Stasis Dermatitis Unknown status NCT00421161 Phase 1, Phase 2 olive oil and omega 3 in a combined cream
50 Efficacy Study of a Peristaltic Pulse Pneumatic Device in the Treatment of Claudication Unknown status NCT01007604 Phase 2

Search NIH Clinical Center for Venous Insufficiency

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Gotu Kola Extract
GOTU KOLA LIQUID

Cochrane evidence based reviews: venous insufficiency

Genetic Tests for Venous Insufficiency

Genetic tests related to Venous Insufficiency:

# Genetic test Affiliating Genes
1 Venous Insufficiency 29

Anatomical Context for Venous Insufficiency

MalaCards organs/tissues related to Venous Insufficiency:

40
Skin, Heart, Testes, Endothelial, Brain, Bone, Breast

Publications for Venous Insufficiency

Articles related to Venous Insufficiency:

(show top 50) (show all 4749)
# Title Authors PMID Year
1
Ultrasound-Accelerated Thrombolysis and Venoplasty for the Treatment of the Postthrombotic Syndrome: Results of the ACCESS PTS Study. 61
31983322 2020
2
Venoplasty and stenting in post-thrombotic syndrome and non-thrombotic iliac vein lesion. 61
30794000 2020
3
Incidence and distribution of lower extremity reflux in patients with pelvic venous insufficiency. 61
30943834 2020
4
Commentary: "Brave Dreams" Reanalysis Sheds New Light on Angioplasty for Venous Anomalies in Some Multiple Sclerosis Patients With Chronic Cerebrospinal Venous Insufficiency. 61
31948374 2020
5
Arteriovenous Fistula after Endovenous Laser Ablation of Great Saphenous Vein Treated with Covered Stent: Case Report and Literature Review. 61
31563655 2020
6
Hemodynamics of cerebral veins analyzed by 2d and 4d flow mri and ultrasound in healthy volunteers and patients with multiple sclerosis. 61
31102341 2020
7
Valproic Acid Decreases Endothelial Colony Forming Cells Differentiation and Induces Endothelial-to-Mesenchymal Transition-like Process. 61
31898801 2020
8
Quality of life after pharmacomechanical catheter-directed thrombolysis for proximal deep venous thrombosis. 61
31843251 2020
9
The Utility of Preoperative Venous Testing for Lower Extremity Flap Planning in Patients with Lower Extremity Wounds. 61
31881626 2020
10
Spontaneous hemorrhage from varicose veins: A single-center experience. 61
31843245 2020
11
[Pros and cons of classic crossectomy with stripping compared to endoluminal treatment : Competition or team play?] 61
31807791 2020
12
Late cardiovascular complication after varicose vein endovascular ablation. 61
31981354 2020
13
Risk Factors of Saphenous Vein Insufficiency in Female Patients in Riyadh, Saudi Arabia. 61
31966948 2020
14
The clinical characteristics of lower extremity lymphedema in 440 patients. 61
31992537 2020
15
Incidence and Risk Factors for Deep Vein Thrombosis after Radiofrequency and Laser Ablation of the Lower Extremity Veins. 61
31201974 2020
16
The lived experience of recurrence prevention in patients with venous leg ulcers: An interpretative phenomenological study. 61
31974010 2020
17
[Innovations in medical compression therapy]. 61
31845297 2020
18
[Lymphedema-clinical picture and therapy]. 61
31912161 2020
19
Effects of the use of bioceramic wraps in patients with lower limb venous ulcers: A randomized double-blind placebo-controlled trial. 61
31818694 2020
20
Long-term Risk of Post-Thrombotic Syndrome after Symptomatic Distal Deep-Vein Thrombosis: The CACTUS-PTS Study. 61
31899848 2020
21
Endovascular stenting for chronic femoro-iliac venous obstructive disease: Clinical efficacy and short-term outcomes. 61
31036535 2020
22
Association between venous reflux and diameter of great saphenous vein in lower thigh. 61
31402294 2020
23
Percutaneous Venous Angioplasty in Patients with Multiple Sclerosis and Chronic Cerebrospinal Venous Insufficiency: A Randomized Wait List Control Study. 61
31445091 2020
24
Endophlebectomy of the common femoral vein and endovascular iliac vein recanalization for chronic iliofemoral venous occlusion. 61
31932247 2020
25
Dancing: More than a therapy for patients with venous insufficiency. 61
31896302 2020
26
Factors that influence venous leg ulcer healing and recurrence rate after endovenous radiofrequency ablation of incompetent saphenous vein. 61
31843485 2019
27
Hybrid perforator flaps: Introducing a new concept in perforator flap surgery. 61
31879260 2019
28
Laser ablation versus mechanochemical ablation in the treatment of primary varicose veins: A randomized clinical trial. 61
31864932 2019
29
Clinical response to combination therapy in the treatment of varicose veins. 61
31843482 2019
30
Relationship of Lower-extremity Deep Venous Thrombosis Density at CT Venography to Acute Pulmonary Embolism and the Risk of Postthrombotic Syndrome. 61
31592733 2019
31
Accessing the academic influence of vascular surgeons within the National Institutes of Health iCite database. 61
31831311 2019
32
Hydrogen peroxide and cutaneous biology: Translational applications, benefits, and risks. 61
31103570 2019
33
Surgical resection for suppurative thrombophlebitis of the great saphenous vein after radiofrequency ablation. 61
31799481 2019
34
Chronic venous insufficiency: A review for nurses. 61
31764871 2019
35
Chronic venous insufficiency: A review for nurses. 61
31658230 2019
36
Using compression therapy in a primary care setting to treat complications of chronic venous insufficiency. 61
31868823 2019
37
Pivotal Study of Endovenous Stent Placement for Symptomatic Iliofemoral Venous Obstruction. 61
31833414 2019
38
Etiology of iliocaval stent thrombosis. 61
31843484 2019
39
Assessment of the use of Unna boot in the treatment of chronic venous leg ulcers in adults: systematic review protocol. 61
31874878 2019
40
A rare case of arteriovenous fistula formation in a patient with inferior vena cava thrombosis, successfully managed with endovascular recanalisation. 61
31938558 2019
41
[The Artist's Foot by Adolph von Menzel (1876): A realistic portrait of dermatoporosis and venous insufficiency]. 61
31601441 2019
42
Examining risk factors and preventative treatments for first venous leg ulceration: a cohort study. 61
31884088 2019
43
Level and modalities of origin of the small saphenous vein: toward codification of the proximal approach level. 61
31501911 2019
44
Characteristic Features of Wound Dressings Based on Butyric-Acetic Chitin Copolyesters-Results of Clinical Trials. 61
31842270 2019
45
The versatile free medial sural artery perforator flap: An institutional experience for reconstruction of the head and neck, upper and lower extremities. 61
31821621 2019
46
Cutaneous lymphoid hyperplasia induced by Hirudo medicinalis (leeches). 61
31804958 2019
47
Effects of Venous Angioplasty on Cerebral Lesions in Multiple Sclerosis: Expanded Analysis of the Brave Dreams Double-Blind, Sham-Controlled Randomized Trial. 61
31735108 2019
48
Role of Vascular Ultrasound in Cases of Lower Limb Hyperpigmentation. 61
31896843 2019
49
Percutaneous Venous Angioplasty in Patients with Multiple Sclerosis and Chronic Cerebrospinal Venous Insufficiency. 61
31743778 2019
50
Contemporary management of lower extremity venous aneurysms. 61
31495768 2019

Variations for Venous Insufficiency

Expression for Venous Insufficiency

Search GEO for disease gene expression data for Venous Insufficiency.

Pathways for Venous Insufficiency

Pathways related to Venous Insufficiency according to GeneCards Suite gene sharing:

(show all 37)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.02 VWF VEGFA VCAM1 TIMP1 SELL PLAU
2
Show member pathways
13.35 VWF VEGFA VCAM1 TIMP1 MMP9 MMP1
3
Show member pathways
13.34 VEGFA VCAM1 SERPINE1 PLAU MMP9 MMP1
4
Show member pathways
12.67 VEGFA VCAM1 MMP9 ITGAM ITGA4 ICAM1
5
Show member pathways
12.67 VCAM1 TIMP1 SERPINE1 MMP9 MMP1 ITGAM
6
Show member pathways
12.51 VWF VEGFA TIMP1 SERPINE1 SELP SELL
7
Show member pathways
12.36 VEGFA VCAM1 PLAU ICAM1
8
Show member pathways
12.33 SERPINE1 PLAT MTHFR ICAM1 F2 CRP
9 12.23 PLAU PLAT MMP9 ITGAM
10
Show member pathways
12.22 SELP SELL MMP1 ITGAM ITGA4 F2
11
Show member pathways
12.2 VEGFA TIMP1 SERPINE1 MMP1
12
Show member pathways
12.17 VWF VCAM1 ITGAM ITGA4 ICAM1
13
Show member pathways
12.16 VWF SERPINE1 PLAU PLAT F5 F2
14 12.11 VEGFA VCAM1 PLAT MMP9 ICAM1
15 12.07 VCAM1 SELL ITGA4 ICAM1
16 12.05 VCAM1 SELP SELL ITGAM ITGA4 ICAM1
17 12.04 VCAM1 SERPINE1 MMP9 ITGA4 ICAM1
18
Show member pathways
12.03 PLAT MMP9 ITGAM F2
19 12.03 VWF SERPINE1 PLAU PLAT ITGAM F5
20 11.92 VEGFA VCAM1 SERPINE1 ICAM1
21 11.8 VWF TIMP1 MMP9
22 11.76 VEGFA VCAM1 TIMP1 MMP9 MMP1 ITGAM
23 11.71 VEGFA MMP9 MMP1
24 11.71 VEGFA PLAU PLAT MMP9
25 11.69 TIMP1 PLAU MMP9 ELN
26
Show member pathways
11.63 VEGFA VCAM1 MMP9 MMP1 ICAM1
27 11.53 VCAM1 SELP ICAM1
28 11.52 VEGFA PLAU PLAT
29 11.52 TIMP1 SERPINE1 PLAU PLAT MMP9 MMP1
30 11.5 VCAM1 ITGAM ITGA4 ICAM1
31 11.43 SELL MMP9 MMP1 ELN
32 11.34 PLAU MMP9 MMP1
33
Show member pathways
11.28 VEGFA TIMP1 CRP
34 11.21 TIMP1 MMP9 ICAM1 F2
35 11.11 SELP PLAU PLAT MMP9 ITGAM ICAM1
36 11.07 VEGFA TIMP1 MMP1
37 10.87 SERPINE1 PLAU PLAT

GO Terms for Venous Insufficiency

Cellular components related to Venous Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 10.11 VWF VCAM1 TIMP1 SERPINE1 PLAU PLAT
2 extracellular region GO:0005576 10.07 VWF VEGFA TIMP1 SERPINE1 PLAU PLAT
3 cell surface GO:0009986 9.92 VEGFA VCAM1 PLAU PLAT NDP ITGAM
4 external side of plasma membrane GO:0009897 9.88 VCAM1 SELP SELL ITGAM ICAM1 F2
5 extracellular matrix GO:0031012 9.83 VEGFA TIMP1 MMP9 MMP1 ELN
6 collagen-containing extracellular matrix GO:0062023 9.56 VWF SERPINE1 PLAT NDP MMP9 ICAM1
7 platelet alpha granule lumen GO:0031093 9.55 VWF VEGFA TIMP1 SERPINE1 F5
8 extracellular space GO:0005615 9.47 VEGFA VCAM1 TIMP1 SERPINE1 SELP PLAU

Biological processes related to Venous Insufficiency according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 10.04 VWF VCAM1 SELP SELL ITGAM ITGA4
2 blood coagulation GO:0007596 9.91 VWF PLAU PLAT F5 F2
3 regulation of immune response GO:0050776 9.89 VCAM1 SELL ITGA4 ICAM1
4 cellular protein metabolic process GO:0044267 9.88 TIMP1 MMP1 F5 F2
5 response to hypoxia GO:0001666 9.88 VEGFA VCAM1 PLAU PLAT MTHFR ICAM1
6 cytokine-mediated signaling pathway GO:0019221 9.87 VEGFA VCAM1 TIMP1 MMP9 MMP1 ITGAM
7 hemostasis GO:0007599 9.76 VWF PLAU F5 F2
8 extracellular matrix disassembly GO:0022617 9.75 TIMP1 MMP9 MMP1
9 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.73 VCAM1 SELP ICAM1
10 leukocyte cell-cell adhesion GO:0007159 9.73 VCAM1 SELP ITGA4 ICAM1
11 cellular response to amyloid-beta GO:1904646 9.71 VCAM1 ITGA4 ICAM1
12 fibrinolysis GO:0042730 9.67 SERPINE1 PLAU PLAT F2
13 positive regulation of leukocyte migration GO:0002687 9.65 VEGFA SELP ITGA4
14 platelet degranulation GO:0002576 9.63 VWF VEGFA TIMP1 SERPINE1 SELP F5
15 plasminogen activation GO:0031639 9.61 PLAU PLAT
16 negative regulation of fibrinolysis GO:0051918 9.6 SERPINE1 F2
17 smooth muscle cell migration GO:0014909 9.57 PLAU PLAT
18 leukocyte tethering or rolling GO:0050901 9.56 VCAM1 SELP SELL ITGA4
19 membrane to membrane docking GO:0022614 9.55 VCAM1 ICAM1
20 cell-cell adhesion in response to extracellular stimulus GO:0140039 9.52 VCAM1 ITGA4
21 leukocyte migration GO:0050900 9.5 SELP SELL MMP1 ITGAM ITGA4 ICAM1
22 extracellular matrix organization GO:0030198 9.28 VWF VCAM1 SERPINE1 MMP9 MMP1 ITGAM

Molecular functions related to Venous Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.8 PLAU PLAT MMP9 MMP1 F2
2 heparin binding GO:0008201 9.56 VEGFA SELP SELL F2
3 cell adhesion molecule binding GO:0050839 9.5 VCAM1 SELL ITGA4
4 oligosaccharide binding GO:0070492 9.37 SELP SELL
5 protease binding GO:0002020 9.26 VWF TIMP1 SERPINE1 SELL
6 glycosphingolipid binding GO:0043208 9.16 SELP SELL
7 serine-type endopeptidase activity GO:0004252 9.02 PLAU PLAT MMP9 MMP1 F2

Sources for Venous Insufficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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