MCID: VNS003
MIFTS: 55

Venous Insufficiency

Categories: Blood diseases, Cardiovascular diseases

Aliases & Classifications for Venous Insufficiency

MalaCards integrated aliases for Venous Insufficiency:

Name: Venous Insufficiency 12 29 44 15 72 33
Peripheral Venous Insufficiency 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10128
ICD9CM 35 459.81
MeSH 44 D014689
NCIt 50 C127822
SNOMED-CT 68 20696009
ICD10 33 I87.2
UMLS 72 C0042485

Summaries for Venous Insufficiency

Disease Ontology : 12 A vein disease that is characterized by impaired flow of blood through the veins.

MalaCards based summary : Venous Insufficiency, also known as peripheral venous insufficiency, is related to lipodermatosclerosis and post-thrombotic syndrome. An important gene associated with Venous Insufficiency is PLAT (Plasminogen Activator, Tissue Type), and among its related pathways/superpathways are Innate Immune System and Integrin Pathway. The drugs Hesperidin and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and endothelial, and related phenotypes are cardiovascular system and homeostasis/metabolism

Related Diseases for Venous Insufficiency

Diseases in the Venous Insufficiency family:

Chronic Venous Insufficiency

Diseases related to Venous Insufficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 338)
# Related Disease Score Top Affiliating Genes
1 lipodermatosclerosis 32.9 PLAT MMP1
2 post-thrombotic syndrome 32.7 SERPINE1 ICAM1 F2
3 thrombophlebitis 31.2 SERPINE1 PLAT F2
4 chronic venous insufficiency 31.0 VCAM1 TIMP1 SERPINE1 SELP SELL PLAT
5 vein disease 30.7 SERPINE1 PLAT F2
6 thrombophilia due to thrombin defect 30.6 VWF SERPINE1 PLAT F2
7 multiple sclerosis 30.4 VCAM1 MMP9 ITGA4 ICAM1
8 relapsing-remitting multiple sclerosis 30.2 TIMP1 MMP9 ICAM1
9 amaurosis fugax 30.2 SERPINE1 MMP9
10 thrombophilia 30.1 VWF SERPINE1 F2
11 demyelinating disease 30.0 MMP9 ITGA4 ICAM1
12 varicose veins 30.0 VWF TIMP1 MMP9 MMP1 F2
13 microvascular complications of diabetes 5 29.7 VCAM1 SERPINE1 ICAM1
14 primary progressive multiple sclerosis 29.6 VCAM1 MMP9 ICAM1
15 arteriosclerosis obliterans 29.6 VCAM1 SELP ICAM1
16 thrombosis 29.4 VWF SERPINE1 SELP PLAT F2
17 peripheral artery disease 29.0 VCAM1 SELP CRP
18 coronary heart disease 1 28.9 SERPINE1 SELP PLAT CRP
19 pulmonary embolism 28.9 VWF SERPINE1 PLAT F2 CRP
20 purpura 28.8 VWF F2 CRP
21 endocarditis 28.7 VCAM1 PLAT F2 CRP
22 pulmonary disease, chronic obstructive 28.3 TIMP1 MMP9 MMP1 CRP
23 synovitis 28.3 VCAM1 MMP1 ICAM1 CRP
24 vasculitis 28.1 VWF VCAM1 SELL ICAM1 CRP
25 peripheral vascular disease 27.6 VWF VCAM1 SERPINE1 SELP PLAT F2
26 proteasome-associated autoinflammatory syndrome 1 27.5 VCAM1 SELP SELL MMP9 ICAM1 CRP
27 systemic lupus erythematosus 27.5 VWF VCAM1 ICAM1 F2 CRP
28 arteriosclerosis 27.4 VCAM1 SERPINE1 SELP MMP9 ICAM1 CRP
29 vascular disease 27.2 VWF VCAM1 SERPINE1 SELP PLAT MMP9
30 cerebrovascular disease 25.9 VWF VCAM1 SERPINE1 SELP PLAT MMP9
31 fibrinolytic defect 10.7 SERPINE1 PLAT
32 plasminogen activator inhibitor-1 deficiency 10.6 SERPINE1 PLAT
33 central serous chorioretinopathy 10.6 SERPINE1 PLAT
34 argentine hemorrhagic fever 10.6 SERPINE1 PLAT
35 intracranial embolism 10.6 PLAT F2
36 cryptogenic cirrhosis 10.5 SERPINE1 F2
37 toxicodendron dermatitis 10.5 SELL ICAM1
38 marantic endocarditis 10.5 PLAT F2
39 acute cor pulmonale 10.5 SERPINE1 PLAT
40 autoimmune inner ear disease 10.4 TIMP1 MMP9
41 chronic eosinophilic pneumonia 10.4 ITGA4 ICAM1
42 plummer's disease 10.4 SELL ICAM1
43 hydrocele 10.4 ITGA4 ICAM1
44 livedoid vasculitis 10.4 SERPINE1 F2
45 pediatric multiple sclerosis 10.4 MMP9 ITGA4
46 carotid artery thrombosis 10.4 SERPINE1 SELP PLAT
47 hydrops, lactic acidosis, and sideroblastic anemia 10.4
48 peliosis hepatis 10.4 SELL ITGA4 F2
49 disseminated intravascular coagulation 10.4 SERPINE1 PLAT F2
50 fungal keratitis 10.4 TIMP1 MMP9

Comorbidity relations with Venous Insufficiency via Phenotypic Disease Network (PDN): (show all 20)


Acute Cystitis Aortic Valve Disease 1
Bronchitis Chronic Pulmonary Heart Disease
Decubitus Ulcer Deficiency Anemia
Familial Atrial Fibrillation Femoral Vein Thrombophlebitis
Generalized Atherosclerosis Heart Disease
Hypertension, Essential Hypothyroidism
Iron Deficiency Anemia Mitral Valve Disease
Osteoporosis Peripheral Vascular Disease
Post-Thrombotic Syndrome Protein-Energy Malnutrition
Schizophreniform Disorder Tinea Pedis

Graphical network of the top 20 diseases related to Venous Insufficiency:



Diseases related to Venous Insufficiency

Symptoms & Phenotypes for Venous Insufficiency

MGI Mouse Phenotypes related to Venous Insufficiency:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.23 CRP F2 ICAM1 ITGA4 MMP9 PLAT
2 homeostasis/metabolism MP:0005376 10.15 CRP F2 ICAM1 MMP1 MMP9 PLAT
3 hematopoietic system MP:0005397 10.14 F2 ICAM1 ITGA4 MMP9 PLAT SELL
4 immune system MP:0005387 10.13 CRP F2 ICAM1 ITGA4 MMP1 MMP9
5 growth/size/body region MP:0005378 10.09 F2 ICAM1 MMP9 PLAT SELL SELP
6 mortality/aging MP:0010768 9.85 F2 ICAM1 ITGA4 MMP9 PLAT SELP
7 integument MP:0010771 9.8 F2 ICAM1 MMP9 PLAT SELL SELP
8 neoplasm MP:0002006 9.43 ICAM1 MMP1 MMP9 SELL SERPINE1 TIMP1
9 respiratory system MP:0005388 9.17 F2 MMP9 PLAT SELL SELP SERPINE1

Drugs & Therapeutics for Venous Insufficiency

DrugBank drugs 16 :

# Drug Name Indication DrugBank ID
1 Polidocanol Polidocanol is a sclerosing agent indicated to treat uncomplicated spider veins and uncomplicated reticular veins in the lower extremity. DB06811

Drugs for Venous Insufficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 155)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hesperidin Approved, Investigational Phase 4 520-26-3 53477767
2
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
3
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
4
Racepinephrine Approved Phase 4 329-65-7 838
5
Glucosamine Approved, Investigational Phase 4 3416-24-8 439213
6
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
7
Serine Approved, Nutraceutical Phase 4 56-45-1 5951
8
Coumarin Experimental Phase 4 91-64-5 323
9
Troxerutin Investigational Phase 4 7085-55-4 5486699
10 Heparinoids Phase 4
11 Aminaftone Phase 4
12 Calcium, Dietary Phase 4
13 Rosuvastatin Calcium Phase 4 147098-20-2
14 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
15 Anticholesteremic Agents Phase 4
16 Central Nervous System Depressants Phase 4
17 Anesthetics, Local Phase 4
18 Antithrombin III Phase 4
19 HIV Protease Inhibitors Phase 4
20
protease inhibitors Phase 4
21 Serine Proteinase Inhibitors Phase 4
22 Antithrombins Phase 4
23 Factor Xa Inhibitors Phase 4
24 Neurotransmitter Agents Phase 4
25 Adrenergic Agents Phase 4
26 Anti-Arrhythmia Agents Phase 4
27 Sympathomimetics Phase 4
28 Sodium Channel Blockers Phase 4
29 Adrenergic Agonists Phase 4
30 Respiratory System Agents Phase 4
31 Adrenergic alpha-Agonists Phase 4
32 Adrenergic beta-Agonists Phase 4
33 Diuretics, Potassium Sparing Phase 4
34 Epinephryl borate Phase 4
35 Peripheral Nervous System Agents Phase 4
36 Mydriatics Phase 4
37 Anti-Asthmatic Agents Phase 4
38 Vasoconstrictor Agents Phase 4
39 Autonomic Agents Phase 4
40 Bronchodilator Agents Phase 4
41 Anticoagulants Phase 4
42 Fibrinolytic Agents Phase 4
43 Lipid Regulating Agents Phase 4
44 Hypolipidemic Agents Phase 4
45 Antimetabolites Phase 4
46 Glucuronyl glucosamine glycan sulfate Phase 4
47 Hypoglycemic Agents Phase 4
48
carbamide peroxide Approved Phase 2, Phase 3 124-43-6
49
Heparin Approved, Investigational Phase 3 9005-49-6 46507594 772
50
tannic acid Approved Phase 3 1401-55-4

Interventional clinical trials:

(show top 50) (show all 229)
# Name Status NCT ID Phase Drugs
1 A 6-week, Open, Multicentre Safety Trial to Evaluate the Tolerability Profile of Antistax® Film Coated Tablets (Extr. Vitis Viniferae Siccum), 360 mg/Day Per os, in Male and Female Patients Suffering From Chronic Venous Insufficiency Completed NCT02184234 Phase 4 Antistax film coated tablets
2 Evaluate the Efficacy and Safety of Esarin Gel in the Treatment of Chronic Venous Insufficiency or Varicose Vein Combine With Superficial Vein Thrombophlebitis in Outpatient Completed NCT02346058 Phase 4 Esarin Gel
3 The Fate Of Calf Perforators After Endovenous Laser Ablation Of Saphenous Veins Completed NCT01458795 Phase 4
4 Multicenter, Prospective, Randomized, Double-Blind Study to Assess the Therapeutic Efficacy and Safety of the Use of Venocur Triplex® in Patients With Chronic Venous Insufficiency Completed NCT00835822 Phase 4 Venocur Triplex®;placebo
5 Gliding Aids for Medical Compression Stockings - Practicability in Elderly Patients With Chronic Venous Insufficiency Completed NCT01432795 Phase 4
6 Evaluation of Efficacy and Safety of the Fixed-dose Combination of Coumarin and Troxerutin (Venalot®) Versus Placebo in the Symptomatic Treatment of Chronic Venous Insufficiency - VENACT Completed NCT01848210 Phase 4 Coumarin/troxerutin;Placebo
7 Randomized Double-blind Trial Between Clinical and Endovascular Treatment in Patients With Advanced Chronic Venous Insufficiency and Iliac Venous Obstruction Completed NCT02149212 Phase 4 Phlebotonic
8 Clinical Non-inferiority Study Between Diosmin 600 mg Tablets and Diosmin 900 mg + Hesperidin 100 mg Tablets in Symptomatic Chronic Venous Insufficiency After 6 Months of Treatment: Single-blind, Randomized, Parallel Group Study Completed NCT03471910 Phase 4 Diosmin;Diosmin / Hesperidin
9 SocknLeg - a User Friendly Medical Compression Study of a Modified Application of a Medical Device Completed NCT02621632 Phase 4
10 The Effect of Neuromuscular Electrical Therapy on Pain in Patients With Venous Ulcers: a Controlled Clinical Trial Completed NCT01372020 Phase 4
11 Radiofrequency Ablation vs Laser Ablation of the Incompetent Greater Saphenous Vein: A Prospective Randomized Trial Completed NCT02236338 Phase 4
12 A Pilot Trial of the Use of ReCell® Autologous Cell Harvesting Device for Venous Leg Ulcers Completed NCT01743053 Phase 4
13 Polidocanol Versus Glucose For Sclerotherapy Treatment Of Telangiectasia Of The Lower Limbs: Protocol For A Randomized, Controlled Clinical Trial Completed NCT02657252 Phase 4 Glucose;Polidocanol with Glucose
14 A Randomized Triple-blind Study Protocol Comparing Polidocanol Versus Hypertonic Glucose for Sclerotherapy in Treatment of Reticular Veins at the Lower Limbs. Completed NCT02054325 Phase 4 Polidocanol with Glucose;Glucose
15 Role of Statin in Venous Dysfunction in Patients With Venous Thromboembolism Event Recruiting NCT03988101 Phase 4 Rosuvastatin 20mg;Control
16 The Efficacy of Rivaroxaban With Diosmine in the Long-term Treatment of Acute Proximal Deep Vein Thrombosis Active, not recruiting NCT03413618 Phase 4 Rivaroxaban;Diosmin
17 A Randomised Clinical Trial Comparing Endovenous Laser Ablation and Mechanochemical Ablation (ClariVein®) in the Management of Superficial Venous Insufficiency Active, not recruiting NCT02627846 Phase 4 Lidocaine with 1:200,000 epinephrine solution;Lidocaine with 1:200,000 epinephrine solution;Sodium Bicarbonate;Sodium Tetradecyl Sulphate
18 Study of Antiinflammatory Effects of Detralex (Daflon) in Patients With Chronic Venous Disease Enrolling by invitation NCT01654016 Phase 4 Detralex
19 Radiofrequency Ablation vs. Laser Ablation of the Incompetent Small Saphenous Vein: A Prospective Randomized Trial Terminated NCT02248740 Phase 4
20 Prospective Evaluation of the Quality of Life of Patients With Post-thrombotic Syndrome Who Receive Compression Therapy and Sulodexide — SQUARES Study Terminated NCT02512601 Phase 4 Sulodexide
21 A Randomized Trial of the Flexitouch Compression System as an Adjunctive Treatment for Venous Stasis Ulcer Terminated NCT00534937 Phase 4
22 A Randomised Clinical Trial Comparing Standard Cannula Delivered Foam Sclerotherapy, Catheter Directed Foam Sclerotherapy and ClariVein® Mechanochemical Ablation in the Management of Superficial Venous Insufficiency. Withdrawn NCT02010437 Phase 4 Sodium Tetradecyl Sulphate (STS)
23 A Clinical Multicenter, Phase III, Prospective, Randomized, Double-blind, Comparative Study to Evaluate the Efficacy and Tolerability of Venaflon Use in Reducing the Symptoms Caused by Chronic Venous Insufficiency When Compared With Daflon Unknown status NCT01477281 Phase 3 Daflon;Venaflon (Diosmin and Hesperidin)
24 Study Clinical, Multicenter,Phase III,Prospective,Randomized,Comparative Double Blind/Double-dummy to Assess the Efficacy and Tolerability of the Use of Varicell in Reducing the Symptoms Caused by Chronic Venous Insufficiency and Hemorrhoidal Syndrome When Compared With Daflon Unknown status NCT01321619 Phase 3 Daflon;Varicell placebo
25 Comparative Efficacy of Two Preparations of the Association Diosmin (450 mg) + Hesperidin (50 mg) in the Treatment of Chronic Venous Insufficiency (CVI) Unknown status NCT01110512 Phase 3 Flavonid;Daflon
26 A Comparative Study to Assess the Efficacy and Safety of Endolex Forte vs Diosmin and Hesperidin in Reducing the symptomatoLogy of Patients With ChronIc VeNous Insufficiency Between Functional Classes CEAP 1-4, During a Period of 6 Months Unknown status NCT02927483 Phase 3
27 A Prospective, Multi-Centre, Double Blind, Randomized, Placebo Controlled Trial to Evaluate the Safety and Efficacy of ICXP007 in a Phase III Trial With Four-Layer Therapeutic Compression, for the Treatment of Non-Infected Skin Leg Ulcers, Due to Venous-Insufficiency Unknown status NCT00232973 Phase 3 ICXP007
28 Efficacy of Autologous Platelet-Rich Plasma in the Treatment of Vascular Ulcers in Primary Care: Clinical Trial Phase III Unknown status NCT02213952 Phase 3 Platelet-Rich Plasma
29 Randomized Single Center Comparative Study of the Treatment of Insufficient Greater Saphenous Vein: Surgery vs Ultrasound Guided Sclerotherapy With Foam and Endovenous Laser Therapy Unknown status NCT00529672 Phase 3
30 A 12-week, Double-blind, Randomised, Placebo-controlled, Multicentre Trial to Evaluate Efficacy and Tolerability of Antistax Film-coated Tablets, 360 mg/Day Orally, in Male and Female Patients Suffering From Chronic Venous Insufficiency. Completed NCT00292435 Phase 3 Read vine leaf extract (AS 195)
31 A 12-week, Double-blind, Randomised, Placebo-controlled, Multicentre Trial to Evaluate Efficacy and Tolerability of Antistax® Film Coated Tablets, 360 mg/Day Orally, in Male and Female Patients Suffering From Chronic Venous Insufficiency Completed NCT02191254 Phase 3 Antistax®;Placebo
32 Prospective, Randomized and Explorative Controlled Study About Influences of Compression Stockings on Skin's Barrier Function at Patients With Chronic Venous Insufficiency Completed NCT00196443 Phase 2, Phase 3
33 A 12-week, Double-blind, Randomised, Placebo-controlled, Multicentre Trial to Evaluate Efficacy and Tolerability of Antistax® Film Coated Tablets, 720 mg/Day Orally, in Male and Female Patients Suffering From Chronic Venous Insufficiency Completed NCT00855179 Phase 3 Red vine leaf extract (AS 195);Placebo
34 Clinical Study of BNS003 on Swelling Due to Disorder of Leg Venous Reflux Completed NCT02211898 Phase 3 BNS003
35 Evaluation of the Efficacy of Spa Treatment for Prevention of Leg Ulcers in Advanced Chronic Venous Insufficiency. Completed NCT00838500 Phase 3 Immediate spa treatment;Late spa treatment
36 Crenobalneotherapy in the Treatment of Chronic Venous Insufficiency. A Randomized Clinical Trial. Completed NCT01956318 Phase 3
37 Efficacy on Volume Reduction and Tolerance of Progressiv' Medical Compressive Therapy (MCT) V0322 BC in Patients With Chronic Venous Oedema. International, Multicentric, Randomised, Controlled, Double Blind Study, in Two Parallel Groups v0322 bc Versus Placebo Completed NCT01402921 Phase 3
38 Treatment of Greater Saphenous Vein (GSV) Insufficiency Using Echo-Guided Sclerotherapy With Lauromacrogol 400 Foam –Comparative Study of 3% Versus 1% Concentration. Completed NCT00348764 Phase 3 lauromacrogol
39 Deep Venous Thrombosis. Long-Term Results After Treatment With Either Low-Molecular -Weight Heparin or Unfractionated Heparin. Examinations of the Venous System. Completed NCT00628576 Phase 3 unfractionated heparin;Tinzaparin (Leo)
40 A Phase 3 Randomized, Double Blind, Vehicle Controlled Study Investigating the Safety and Efficacy of HP802-247 in the Treatment of Venous Leg Ulcers >12 cm2 to ≤ 36 cm2 Completed NCT01737762 Phase 3
41 Double Blind Randomized Controlled Trial of Recombinant Human Platelet Derived Growth Factor-BB Gel (Regranex Gel®) Versus Hydrogel (Duoderm Hydrogel®) for Healing of MARTORELL's Hypertensive Leg Ulcers. ERAN Trial. Completed NCT00970697 Phase 3 becaplermin gel;Duoderm Hydrogel™
42 Zoledronic Acid or Methylprednisolone in the Management of Active Charcot's Neuroarthropathy of Foot in Patients With Diabetes Mellitus: A Randomized, Double-blind, Placebo Controlled Trial Completed NCT03289338 Phase 2, Phase 3 Zoledronic Acid;Methylprednisolone;Placebos
43 Double Blind, Randomized, Placebo Controlled Clinical Trial for the Treatment of Diabetic Foot Ulcers, Using a Nitric Oxide Releasing Patch: PATHON Completed NCT00428727 Phase 3 Controlled nitric oxide releasing patch;placebo patch
44 The MUFFIN-PTS Trial: Micronized Purified Flavonoid Fraction for the Treatment of Post-Thrombotic Syndrome Not yet recruiting NCT03833024 Phase 3 Micronized Purified Flavonoid Fraction;Placebo
45 A Phase 3 Randomized Safety and Efficacy Trial of HP802-247 in the Treatment of Chronic Venous Leg Ulcers (EU) Terminated NCT01853384 Phase 3
46 Clinical Evaluation of the Safety and Effectiveness of Topical Autologous Platelet Gel (APG) for the Treatment of Lower Extremity Chronic Venous Insufficiency Ulcers. A Multicenter, Randomized, Controlled Clinical Trial Withdrawn NCT00273234 Phase 3
47 Endovenous Treatment of the Saphenous Vein With Biolitec 1470nm Laser Versus Vnus Closure Fast Unknown status NCT01972633 Phase 1, Phase 2
48 Phase 1 and 2 Study on the Efficacy and Side Effects of Olive Oil and Omega 3 Local Treatment in Stasis Dermatitis Unknown status NCT00421161 Phase 1, Phase 2 olive oil and omega 3 in a combined cream
49 A Prospective Double Blind Randomized Controlled Trial Of Electrocoagulation Versus Radiofrequency Treatment Of The Great Saphenous Vein In Patients With Varicose Veins. Unknown status NCT02139085 Phase 2
50 Efficacy Study of a Peristaltic Pulse Pneumatic Device in the Treatment of Claudication Unknown status NCT01007604 Phase 2

Search NIH Clinical Center for Venous Insufficiency

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Gotu Kola Extract
GOTU KOLA LIQUID
Polidocanol

Cochrane evidence based reviews: venous insufficiency

Genetic Tests for Venous Insufficiency

Genetic tests related to Venous Insufficiency:

# Genetic test Affiliating Genes
1 Venous Insufficiency 29

Anatomical Context for Venous Insufficiency

MalaCards organs/tissues related to Venous Insufficiency:

41
Skin, Testes, Endothelial, Brain, Bone, Breast, Heart

Publications for Venous Insufficiency

Articles related to Venous Insufficiency:

(show top 50) (show all 4672)
# Title Authors PMID Year
1
Tissue-engineered transcatheter vein valve. 38
31195302 2019
2
Vascular training does matter in the outcomes of saphenous high ligation and stripping. 38
31068278 2019
3
Efficacy of balloon venoplasty alone in the correction of nonthrombotic iliac vein lesions. 38
31176659 2019
4
Virchow's triad in "silent" deep vein thrombosis. 38
31078515 2019
5
Safety and efficacy of venous ablation in octogenarians. 38
31421837 2019
6
Overview of venous pathology related to repetitive vascular trauma in athletes. 38
31231058 2019
7
Mechanochemical ablation as an alternative to venous ulcer healing compared with thermal ablation. 38
31421838 2019
8
Endovenous cyanoacrylate glue to treat varicose veins and chronic venous insufficiency-Experience gained from our first 100+ truncal venous ablations in a multi-ethnic Asian population using the Medtronic VenaSeal™ Closure System. 38
30691376 2019
9
Ablation therapy with cyanoacrylate glue and laser for refluxing great saphenous veins - a prospective randomised study. 38
31014200 2019
10
Impact of Great Saphenous Vein Foam Sclerotherapy on Quality of Life and Photoplethysmography Findings in Chronic Venous Insufficiency: One-Year Follow-up. 38
31397782 2019
11
Histopathological changes to the vascular wall after treatment of great saphenous veins using n-butyl-2-cyanoacrylate. 38
31063085 2019
12
Survival and Comparison of External Bleeding Methods in Artery-Only Distal Finger Replantations. 38
31421938 2019
13
Association between venous reflux and diameter of great saphenous vein in lower thigh. 38
31402294 2019
14
Expression profile of tRNA‑derived fragments and their potential roles in human varicose veins. 38
31432124 2019
15
Scientific Papers and Patents on Substances with Unproven Effects. Part 2. 38
31424374 2019
16
The influence of May-Thurner syndrome on post-thrombotic syndrome in young women. 38
30848698 2019
17
One-Year Results of Iliocaval Stenting. 38
30826434 2019
18
Therapeutic potential of natural compounds in inflammation and chronic venous insufficiency. 38
31096120 2019
19
High tolerance of progressive elastic compression in peripheral arterial disease. 38
31159678 2019
20
Chronic venous insufficiency and venous microangiopathy: management with compression and Pycnogenol®. 38
31347820 2019
21
[Chronic leg ulcers in older patients]. 38
31187184 2019
22
Saphenous vein histopathology 5.5 years after cyanoacrylate closure. 38
31281102 2019
23
Defining the utility of anteroposterior venography in the diagnosis of venous iliofemoral obstruction. 38
30926244 2019
24
Is it necessary to dilate stents in management of nonthrombotic iliac vein lesions? 38
31203858 2019
25
Influences of sodium and glycosaminoglycans on skin oedema and the potential for ulceration: a finite-element approach. 38
31417698 2019
26
Distribution of psychogenic and vascular impotence in a tertiary health-care center's cohort: A retrospective study using penile Doppler imaging. 38
31272908 2019
27
Biobehavioral Mechanisms Associated With Nonhealing Wounds and Psychoneurologic Symptoms (Pain, Cognitive Dysfunction, Fatigue, Depression, and Anxiety) in Older Individuals With Chronic Venous Leg Ulcers. 38
31142148 2019
28
Examination of the effects of a new compression garment on skin tissue oxygenation in healthy volunteers. 38
31295092 2019
29
Severe phlebitis-like abnormal reaction following great saphenous vein cyanoacrylate closure. 38
31078516 2019
30
Complete blood count and penile colour doppler ultrasonography findings in erectile dysfunction: Is there a relationship? 38
31273827 2019
31
May-Thurner Syndrome: An often-missed cause of chronic pelvic pain. 38
30908405 2019
32
Relationships between the use of pharmacomechanical catheter-directed thrombolysis, sonographic findings, and clinical outcomes in patients with acute proximal DVT: Results from the ATTRACT Multicenter Randomized Trial. 38
31354089 2019
33
Medical compression stockings on the skin moisture in patients with chronic venous disease. 38
31364497 2019
34
Therapeutic compression materials and wound dressings for chronic venous insufficiency: A comprehensive review. 38
31339655 2019
35
A critical review on the three-dimensional finite element modelling of the compression therapy for chronic venous insufficiency. 38
31319767 2019
36
A near-infrared spectroscopy-assisted test discriminates patients with peripheral arterial disease and venous insufficiency with changes of foot oxygenation following light elastic compression therapy. 38
30838936 2019
37
Neoaorta Reconstruction Using Both Femoral Veins in a Patient with Secondary Aortoenteric Fistula. 38
31142428 2019
38
Impact of Venous Outflow Pattern on Flap Compromise in Head and Neck Reconstruction: Review of 309 Radial Forearm Free Flaps. 38
31166265 2019
39
Procedural training for the management of superficial venous insufficiency: A survey of Rouleaux Club members. 38
31238797 2019
40
MR venography using time-resolved imaging in interventional management of pelvic venous insufficiency. 38
30847564 2019
41
[Endovenous Treatment of Varicose Veins and Chronic Venous Insufficiency]. 38
31163465 2019
42
No association between variations in extracranial venous anatomy and clinical outcomes in multiple sclerosis patients over 5 years. 38
31185944 2019
43
Incidence and Risk Factors for Deep Vein Thrombosis after Radiofrequency and Laser Ablation of the Lower Extremity Veins. 38
31201974 2019
44
Are there differences in risk factors, microbial aspects, and prognosis of cellulitis between compensated and decompensated hepatitis C virus-related cirrhosis? 38
31177653 2019
45
Evaluation of the Isokinetic Calf Muscle Strength and the Range of Motion of Joint in C3 Chronic Venous Insufficiency. 38
31297359 2019
46
Ankle joint mobility as a predictor of treatment prognosis in patients with chronic venous insufficiency with venous ulcers. 38
31360156 2019
47
Escin suppresses HMGB1-induced overexpression of aquaporin-1 and increased permeability in endothelial cells. 38
30972964 2019
48
Radiation exposure during non-thrombotic iliac vein stenting. 38
31067208 2019
49
Protocol for a systematic review and meta-analysis of interventions for pathologic perforator veins in chronic venous disease. 38
31048426 2019
50
Preliminary report of a new type of braided vein stent in animals. 38
30227789 2019

Variations for Venous Insufficiency

Expression for Venous Insufficiency

Search GEO for disease gene expression data for Venous Insufficiency.

Pathways for Venous Insufficiency

Pathways related to Venous Insufficiency according to GeneCards Suite gene sharing:

(show all 36)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.87 VWF VCAM1 TIMP1 SELL MMP9 MMP1
2
Show member pathways
13.27 VCAM1 SERPINE1 MMP9 MMP1 ITGA4 ICAM1
3
Show member pathways
13.21 VWF VCAM1 TIMP1 MMP9 MMP1 ICAM1
4
Show member pathways
12.69 VWF TIMP1 SERPINE1 SELP SELL PLAT
5
Show member pathways
12.53 VCAM1 MMP9 ITGA4 ICAM1
6
Show member pathways
12.45 VCAM1 TIMP1 SERPINE1 MMP9 MMP1 ITGA4
7
Show member pathways
12.23 SERPINE1 PLAT ICAM1 F2 CRP
8
Show member pathways
12.11 SELP SELL MMP1 ITGA4 F2
9
Show member pathways
12.09 VCAM1 MMP9 MMP1 ITGA4 ICAM1 F2
10
Show member pathways
12.08 VWF SERPINE1 PLAT F2
11
Show member pathways
12.05 VWF VCAM1 ITGA4 ICAM1
12 11.99 VCAM1 PLAT MMP9 ICAM1
13 11.98 VWF SERPINE1 PLAT F2
14 11.97 VCAM1 SELP SELL ITGA4 ICAM1
15 11.96 VCAM1 SELL ITGA4 ICAM1
16
Show member pathways
11.93 PLAT MMP9 F2
17 11.9 SELP MMP9 ICAM1
18 11.86 VCAM1 MMP9 ICAM1
19 11.86 VCAM1 SERPINE1 MMP9 ITGA4 ICAM1
20
Show member pathways
11.79 TIMP1 MMP9 MMP1
21 11.79 VCAM1 SERPINE1 ICAM1
22 11.78 VCAM1 TIMP1 MMP9 MMP1 ICAM1
23 11.73 VWF TIMP1 MMP9
24
Show member pathways
11.58 VCAM1 MMP9 MMP1 ICAM1
25 11.46 VCAM1 SELP ICAM1
26 11.42 SELP PLAT MMP9 ICAM1
27 11.4 VCAM1 ITGA4 ICAM1
28 11.33 SELL MMP9 MMP1
29 11.03 PLAT MMP9
30 10.99 MMP1 F2
31 10.94 TIMP1 MMP1
32 10.89 MMP9 MMP1
33 10.85 VCAM1 ICAM1
34 10.85 TIMP1 MMP9 ICAM1 F2
35 10.81 TIMP1 SERPINE1 PLAT MMP9 MMP1
36 10.75 SERPINE1 PLAT

GO Terms for Venous Insufficiency

Cellular components related to Venous Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.92 VWF TIMP1 SERPINE1 PLAT MMP9 MMP1
2 cell surface GO:0009986 9.8 VCAM1 SELL PLAT ITGA4 ICAM1
3 external side of plasma membrane GO:0009897 9.65 VCAM1 SELP SELL ICAM1 F2
4 extracellular matrix GO:0031012 9.61 TIMP1 MMP9 MMP1
5 extracellular exosome GO:0070062 9.61 VWF VCAM1 TIMP1 SERPINE1 PLAT MMP9
6 collagen-containing extracellular matrix GO:0062023 9.55 VWF SERPINE1 PLAT MMP9 ICAM1
7 platelet alpha granule lumen GO:0031093 9.54 VWF TIMP1 SERPINE1
8 extracellular space GO:0005615 9.28 VCAM1 TIMP1 SERPINE1 SELP PLAT MMP9

Biological processes related to Venous Insufficiency according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.88 VWF VCAM1 SELP SELL ITGA4 ICAM1
2 regulation of immune response GO:0050776 9.8 VCAM1 SELL ITGA4 ICAM1
3 response to hypoxia GO:0001666 9.77 VCAM1 PLAT ICAM1
4 cytokine-mediated signaling pathway GO:0019221 9.77 VCAM1 TIMP1 MMP9 MMP1 ICAM1
5 response to lipopolysaccharide GO:0032496 9.76 VCAM1 SELP ICAM1
6 platelet degranulation GO:0002576 9.73 VWF TIMP1 SERPINE1 SELP
7 extracellular matrix disassembly GO:0022617 9.69 TIMP1 MMP9 MMP1
8 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.63 VCAM1 SELP ICAM1
9 extracellular matrix organization GO:0030198 9.63 VWF VCAM1 SERPINE1 MMP9 ITGA4 ICAM1
10 endodermal cell differentiation GO:0035987 9.6 MMP9 ITGA4
11 negative regulation of proteolysis GO:0045861 9.58 PLAT F2
12 calcium-mediated signaling using intracellular calcium source GO:0035584 9.57 VCAM1 SELP
13 blood coagulation, intrinsic pathway GO:0007597 9.56 VWF F2
14 leukocyte cell-cell adhesion GO:0007159 9.56 VCAM1 SELP ITGA4 ICAM1
15 positive regulation of leukocyte migration GO:0002687 9.55 SELP ITGA4
16 positive regulation of blood coagulation GO:0030194 9.54 SERPINE1 F2
17 negative regulation of fibrinolysis GO:0051918 9.52 SERPINE1 F2
18 fibrinolysis GO:0042730 9.5 SERPINE1 PLAT F2
19 membrane to membrane docking GO:0022614 9.48 VCAM1 ICAM1
20 leukocyte migration GO:0050900 9.35 SELP SELL MMP1 ITGA4 ICAM1
21 leukocyte tethering or rolling GO:0050901 8.92 VCAM1 SELP SELL ITGA4

Molecular functions related to Venous Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 9.58 SELP SELL F2
2 serine-type endopeptidase activity GO:0004252 9.56 PLAT MMP9 MMP1 F2
3 integrin binding GO:0005178 9.54 VWF VCAM1 ICAM1
4 cell adhesion molecule binding GO:0050839 9.33 VCAM1 SELL ITGA4
5 oligosaccharide binding GO:0070492 9.32 SELP SELL
6 glycosphingolipid binding GO:0043208 8.96 SELP SELL
7 protease binding GO:0002020 8.92 VWF TIMP1 SERPINE1 SELL

Sources for Venous Insufficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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