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MCID: VNS003
MIFTS: 55

Venous Insufficiency

Categories: Blood diseases, Cardiovascular diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Venous Insufficiency

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MalaCards integrated aliases for Venous Insufficiency:

Name: Venous Insufficiency 12 29 44 15 72 33
Peripheral Venous Insufficiency 12

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:10128
ICD9CM 35 459.81
MeSH 44 D014689
NCIt 50 C127822
SNOMED-CT 68 20696009
ICD10 33 I87.2
UMLS 72 C0042485
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Summaries for Venous Insufficiency

About this section
Disease Ontology : 12 A vein disease that is characterized by impaired flow of blood through the veins.

MalaCards based summary : Venous Insufficiency, also known as peripheral venous insufficiency, is related to lipodermatosclerosis and post-thrombotic syndrome. An important gene associated with Venous Insufficiency is PLAT (Plasminogen Activator, Tissue Type), and among its related pathways/superpathways are Innate Immune System and Integrin Pathway. The drugs Hesperidin and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and endothelial, and related phenotypes are cardiovascular system and homeostasis/metabolism

Sources

Related Diseases for Venous Insufficiency

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Diseases in the Venous Insufficiency family:

Chronic Venous Insufficiency

Diseases related to Venous Insufficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 338, show less)
# Related Disease Score Top Affiliating Genes
1 lipodermatosclerosis 32.9 PLAT MMP1
2 post-thrombotic syndrome 32.7 SERPINE1 ICAM1 F2
3 thrombophlebitis 31.2 SERPINE1 PLAT F2
4 chronic venous insufficiency 31.0 VCAM1 TIMP1 SERPINE1 SELP SELL PLAT
5 vein disease 30.7 SERPINE1 PLAT F2
6 thrombophilia due to thrombin defect 30.6 VWF SERPINE1 PLAT F2
7 multiple sclerosis 30.4 VCAM1 MMP9 ITGA4 ICAM1
8 relapsing-remitting multiple sclerosis 30.2 TIMP1 MMP9 ICAM1
9 amaurosis fugax 30.2 SERPINE1 MMP9
10 thrombophilia 30.1 VWF SERPINE1 F2
11 demyelinating disease 30.0 MMP9 ITGA4 ICAM1
12 varicose veins 30.0 VWF TIMP1 MMP9 MMP1 F2
13 microvascular complications of diabetes 5 29.7 VCAM1 SERPINE1 ICAM1
14 primary progressive multiple sclerosis 29.6 VCAM1 MMP9 ICAM1
15 arteriosclerosis obliterans 29.6 VCAM1 SELP ICAM1
16 thrombosis 29.4 VWF SERPINE1 SELP PLAT F2
17 peripheral artery disease 29.0 VCAM1 SELP CRP
18 coronary heart disease 1 28.9 SERPINE1 SELP PLAT CRP
19 pulmonary embolism 28.9 VWF SERPINE1 PLAT F2 CRP
20 purpura 28.8 VWF F2 CRP
21 endocarditis 28.7 VCAM1 PLAT F2 CRP
22 pulmonary disease, chronic obstructive 28.3 TIMP1 MMP9 MMP1 CRP
23 synovitis 28.3 VCAM1 MMP1 ICAM1 CRP
24 vasculitis 28.1 VWF VCAM1 SELL ICAM1 CRP
25 peripheral vascular disease 27.6 VWF VCAM1 SERPINE1 SELP PLAT F2
26 proteasome-associated autoinflammatory syndrome 1 27.5 VCAM1 SELP SELL MMP9 ICAM1 CRP
27 systemic lupus erythematosus 27.5 VWF VCAM1 ICAM1 F2 CRP
28 arteriosclerosis 27.4 VCAM1 SERPINE1 SELP MMP9 ICAM1 CRP
29 vascular disease 27.2 VWF VCAM1 SERPINE1 SELP PLAT MMP9
30 cerebrovascular disease 25.9 VWF VCAM1 SERPINE1 SELP PLAT MMP9
31 fibrinolytic defect 10.7 SERPINE1 PLAT
32 plasminogen activator inhibitor-1 deficiency 10.6 SERPINE1 PLAT
33 central serous chorioretinopathy 10.6 SERPINE1 PLAT
34 argentine hemorrhagic fever 10.6 SERPINE1 PLAT
35 intracranial embolism 10.6 PLAT F2
36 cryptogenic cirrhosis 10.5 SERPINE1 F2
37 toxicodendron dermatitis 10.5 SELL ICAM1
38 marantic endocarditis 10.5 PLAT F2
39 acute cor pulmonale 10.5 SERPINE1 PLAT
40 autoimmune inner ear disease 10.4 TIMP1 MMP9
41 chronic eosinophilic pneumonia 10.4 ITGA4 ICAM1
42 plummer's disease 10.4 SELL ICAM1
43 hydrocele 10.4 ITGA4 ICAM1
44 livedoid vasculitis 10.4 SERPINE1 F2
45 pediatric multiple sclerosis 10.4 MMP9 ITGA4
46 carotid artery thrombosis 10.4 SERPINE1 SELP PLAT
47 hydrops, lactic acidosis, and sideroblastic anemia 10.4
48 peliosis hepatis 10.4 SELL ITGA4 F2
49 disseminated intravascular coagulation 10.4 SERPINE1 PLAT F2
50 fungal keratitis 10.4 TIMP1 MMP9
51 lymphocytic vasculitis 10.4 VCAM1 ICAM1
52 cortical thymoma 10.3 VCAM1 ICAM1
53 conjunctival nevus 10.3 TIMP1 MMP9
54 cryptogenic organizing pneumonia 10.3 TIMP1 MMP9
55 shwartzman phenomenon 10.3 VCAM1 ICAM1
56 conjunctivochalasis 10.3 TIMP1 MMP1
57 arthus reaction 10.3 SELL ICAM1
58 dowling-degos disease 1 10.3
59 dermatitis 10.3
60 portal vein thrombosis 10.3 SERPINE1 SELP F2
61 gastrointestinal ulceration, recurrent, with dysfunctional platelets 10.2
62 active peptic ulcer disease 10.2 VWF F2
63 brachydactyly, type e2 10.2 VCAM1 ICAM1
64 rheumatoid vasculitis 10.2 VCAM1 ICAM1
65 lymphedema 10.2
66 acute pulmonary heart disease 10.2 SERPINE1 PLAT
67 brachydactyly, type d 10.2 VWF F2
68 retinal vascular occlusion 10.2 SELP F2
69 spastic entropion 10.2 MMP9 MMP1
70 chronic actinic dermatitis 10.2 MMP9 MMP1
71 mooren's ulcer 10.2 VCAM1 ITGA4 ICAM1
72 von willebrand disease, type 1 10.2 VWF F2
73 paresthesia 10.2
74 actinic prurigo 10.2 VCAM1 ITGA4 ICAM1
75 factor viii deficiency 10.2 VWF F2
76 internal hemorrhoid 10.2 MMP9 MMP1
77 chronic ulcer of skin 10.2
78 ischemic colitis 10.2 SERPINE1 MMP9 F2
79 korean hemorrhagic fever 10.1 VWF F2
80 light chain deposition disease 10.1 MMP9 MMP1
81 crescentic glomerulonephritis 10.1 VCAM1 SERPINE1 ICAM1
82 chromoblastomycosis 10.1 MMP9 MMP1
83 kaposi sarcoma 10.1
84 periodontosis 10.1 SELL MMP9
85 nasal cavity squamous cell carcinoma 10.1 TIMP1 MMP9
86 coronary thrombosis 10.1 VWF SERPINE1 PLAT
87 leukostasis 10.1 VCAM1 SELL ICAM1
88 telangiectasis 10.1
89 impotence 10.1
90 adult astrocytic tumour 10.1 MMP9 MMP1
91 malignant otitis externa 10.1 F2 CRP
92 cardiac rupture 10.1 PLAT CRP
93 vernal keratoconjunctivitis 10.1 MMP9 ICAM1
94 muscular dystrophy white matter spongiosis 10.1
95 immune-complex glomerulonephritis 10.1 VCAM1 SELP ICAM1
96 chronic thromboembolic pulmonary hypertension 10.1 F2 CRP
97 abdominal tuberculosis 10.1 F2 CRP
98 platelet aggregation, spontaneous 10.1 VWF SELP PLAT
99 hepatic vascular disease 10.0 VWF SERPINE1 F2
100 generalized atherosclerosis 10.0 SELP CRP
101 afibrinogenemia, congenital 10.0 VWF PLAT F2
102 ischemic neuropathy 10.0 F2 CRP
103 body mass index quantitative trait locus 1 10.0
104 panniculitis 10.0
105 skin disease 10.0
106 ischemia 10.0 SELP PLAT ICAM1
107 limbal stem cell deficiency 10.0 VCAM1 ICAM1
108 hellp syndrome 10.0 VWF SERPINE1 F2
109 dressler's syndrome 10.0 PLAT CRP
110 klippel-trenaunay-weber syndrome 10.0
111 leptin deficiency or dysfunction 10.0
112 hydrocephalus 10.0
113 constipation 10.0
114 necrobiosis lipoidica 10.0
115 peripheral nervous system disease 10.0
116 neuropathy 10.0
117 taylor's syndrome 10.0
118 congenital hydrocephalus 10.0
119 qualitative platelet defect 10.0 VWF SELP F2
120 odontogenic myxoma 10.0 MMP9 MMP1
121 eisenmenger syndrome 10.0 VWF PLAT
122 blood coagulation disease 10.0 VWF SELP F2
123 von willebrand's disease 9.9 VWF SELP F2
124 aortic aneurysm, familial abdominal, 1 9.9 TIMP1 MMP9 MMP1
125 pulmonary emphysema 9.9 TIMP1 MMP9 MMP1
126 pericoronitis 9.9 VCAM1 CRP
127 inguinal hernia 9.9 TIMP1 MMP9 MMP1
128 blood platelet disease 9.9 VWF SELP F2
129 glanzmann thrombasthenia 9.9 VWF SELP F2
130 yemenite deaf-blind hypopigmentation syndrome 9.9
131 varicocele 9.9
132 cellulitis 9.9
133 systemic scleroderma 9.9
134 elephantiasis 9.9
135 localized scleroderma 9.9
136 hemorrhoid 9.9
137 47,xyy 9.9
138 oral lichen planus 9.9 VCAM1 MMP1 ICAM1
139 rapidly progressive glomerulonephritis 9.9 ICAM1 CRP
140 chronic meningitis 9.9 MMP9 CRP
141 blue toe syndrome 9.9 SERPINE1 F2 CRP
142 infective endocarditis 9.9 SERPINE1 F2 CRP
143 subendocardial myocardial infarction 9.8 VCAM1 SERPINE1 ICAM1 F2
144 autoimmune disease 9.8
145 meniere disease 9.8
146 body mass index quantitative trait locus 11 9.8
147 norrie disease 9.8
148 body mass index quantitative trait locus 9 9.8
149 homocysteinemia 9.8
150 body mass index quantitative trait locus 8 9.8
151 body mass index quantitative trait locus 4 9.8
152 body mass index quantitative trait locus 10 9.8
153 body mass index quantitative trait locus 7 9.8
154 body mass index quantitative trait locus 12 9.8
155 body mass index quantitative trait locus 14 9.8
156 body mass index quantitative trait locus 18 9.8
157 body mass index quantitative trait locus 19 9.8
158 body mass index quantitative trait locus 20 9.8
159 secondary progressive multiple sclerosis 9.8
160 sensorineural hearing loss 9.8
161 dermatomyositis 9.8
162 amnestic disorder 9.8
163 sarcoma 9.8
164 chlamydia 9.8
165 erysipelas 9.8
166 lyme disease 9.8
167 goiter 9.8
168 neuritis 9.8
169 ankylosis 9.8
170 tricuspid valve insufficiency 9.8
171 spindle cell sarcoma 9.8
172 congestive heart failure 9.8
173 intracranial hypertension 9.8
174 periostitis 9.8
175 sickle cell disease 9.8
176 48,xyyy 9.8
177 cytokine deficiency 9.8
178 aneurysm 9.8
179 anoxia 9.8
180 autonomic dysfunction 9.8
181 chronic pain 9.8
182 thrombophilia due to activated protein c resistance 9.8 VWF SERPINE1 PLAT F2
183 hemorrhagic disease 9.8 VWF SERPINE1 PLAT F2
184 pleurisy 9.8 SELL ICAM1 CRP
185 thrombocytosis 9.8 SELP F2 CRP
186 hypertension, essential 9.7 VWF SERPINE1 SELP PLAT
187 pulmonary edema 9.7 ICAM1 F2 CRP
188 peritonitis 9.7 ICAM1 F2 CRP
189 essential thrombocythemia 9.7 VWF SERPINE1 SELP F2
190 fibrosarcoma 9.7 TIMP1 SERPINE1 MMP9 MMP1
191 pfeiffer syndrome 9.7
192 cardiac arrhythmia 9.7
193 hypercholesterolemia, familial, 1 9.7
194 lipomatosis, multiple 9.7
195 migraine with or without aura 1 9.7
196 capillary malformations, congenital 9.7
197 porphyria cutanea tarda 9.7
198 pulmonary hypertension, primary, 1 9.7
199 retinoblastoma 9.7
200 sarcoidosis 1 9.7
201 spinal arachnoiditis 9.7
202 tetralogy of fallot 9.7
203 torticollis 9.7
204 vitiligo-associated multiple autoimmune disease susceptibility 6 9.7
205 buerger disease 9.7
206 congenital heart defects, hamartomas of tongue, and polysyndactyly 9.7
207 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 9.7
208 pulmonary alveolar microlithiasis 9.7
209 dermatitis, atopic 9.7
210 vitiligo-associated multiple autoimmune disease susceptibility 1 9.7
211 sick sinus syndrome 3 9.7
212 myelodysplastic syndrome 9.7
213 human herpesvirus 8 9.7
214 helix syndrome 9.7
215 mucocutaneous ulceration, chronic 9.7
216 deficiency anemia 9.7
217 tendinitis 9.7
218 chlamydia pneumonia 9.7
219 aspiration pneumonia 9.7
220 sleep apnea 9.7
221 pain agnosia 9.7
222 acrodermatitis chronica atrophicans 9.7
223 non-alcoholic steatohepatitis 9.7
224 hypogonadotropic hypogonadism 9.7
225 pigmentation disease 9.7
226 osteomyelitis 9.7
227 pleomorphic lipoma 9.7
228 thalassemia 9.7
229 siderosis 9.7
230 meningoencephalitis 9.7
231 portal hypertension 9.7
232 leech infestation 9.7
233 hydronephrosis 9.7
234 arteriovenous malformation 9.7
235 autonomic nervous system disease 9.7
236 ecthyma 9.7
237 optic neuritis 9.7
238 arachnoiditis 9.7
239 common variable immunodeficiency 9.7
240 tinea pedis 9.7
241 tarsal tunnel syndrome 9.7
242 cerebral atherosclerosis 9.7
243 guillain-barre syndrome 9.7
244 transient global amnesia 9.7
245 porphyria 9.7
246 hypermobility syndrome 9.7
247 sick sinus syndrome 9.7
248 hypothyroidism 9.7
249 papilledema 9.7
250 rheumatic disease 9.7
251 retinal vein occlusion 9.7
252 squamous cell carcinoma 9.7
253 calcinosis 9.7
254 status epilepticus 9.7
255 enthesopathy 9.7
256 central retinal vein occlusion 9.7
257 retinal vascular disease 9.7
258 sensory peripheral neuropathy 9.7
259 angiodysplasia 9.7
260 basal cell carcinoma 9.7
261 hemangioma 9.7
262 papilloma 9.7
263 acrodermatitis 9.7
264 auditory system disease 9.7
265 contact dermatitis 9.7
266 pulmonary tuberculosis 9.7
267 thoracic outlet syndrome 9.7
268 mucinoses 9.7
269 granuloma annulare 9.7
270 pyoderma 9.7
271 myopathy 9.7
272 pustulosis of palm and sole 9.7
273 hypokalemia 9.7
274 familial retinoblastoma 9.7
275 brain edema 9.7
276 poliomyelitis 9.7
277 infertility 9.7
278 compartment syndrome 9.7
279 mitochondrial myopathy 9.7
280 premenstrual tension 9.7
281 hemarthrosis 9.7
282 osteoarthritis 9.7
283 lung disease 9.7
284 chronic fatigue syndrome 9.7
285 pyoderma gangrenosum 9.7
286 lupus erythematosus 9.7
287 psoriasis 9.7
288 dermatophytosis 9.7
289 lichen planus 9.7
290 diabetes mellitus 9.7
291 hypertensive encephalopathy 9.7
292 fasciitis 9.7
293 irritable bowel syndrome 9.7
294 hypermobile ehlers-danlos syndrome 9.7
295 homologous wasting disease 9.7
296 may-thurner syndrome 9.7
297 pure autonomic failure 9.7
298 sudden sensorineural hearing loss 9.7
299 encephalopathy 9.7
300 headache 9.7
301 cerebrofacial arteriovenous metameric syndrome 9.7
302 superficial siderosis 9.7
303 overgrowth syndrome 9.7
304 appendicitis 9.7 TIMP1 MMP9 CRP
305 microvascular complications of diabetes 1 9.7 VCAM1 TIMP1 MMP9 ICAM1
306 bone inflammation disease 9.6 TIMP1 MMP1 CRP
307 nervous system disease 9.6 PLAT MMP9 CRP
308 grange syndrome 9.6 VWF VCAM1 SELP PLAT
309 henoch-schoenlein purpura 9.6 VCAM1 ICAM1 CRP
310 gastrointestinal system disease 9.6 MMP9 F2 CRP
311 peripheral vertigo 9.5 F2 CRP
312 respiratory system disease 9.5 MMP9 ICAM1 CRP
313 pulmonary fibrosis, idiopathic 9.5 VCAM1 TIMP1 MMP9 MMP1
314 preterm premature rupture of the membranes 9.5 MMP9 MMP1 CRP
315 kawasaki disease 9.4 TIMP1 SELL MMP9 CRP
316 atherosclerosis susceptibility 9.4 VCAM1 SERPINE1 ICAM1 CRP
317 antiphospholipid syndrome 9.3 VWF VCAM1 SELP PLAT F2
318 intermediate coronary syndrome 9.3 VWF SELP PLAT CRP
319 coronary artery anomaly 9.3 SERPINE1 SELP PLAT F2 CRP
320 coronary stenosis 9.2 VWF SERPINE1 ICAM1 CRP
321 carotid artery disease 9.2 TIMP1 MMP9 MMP1 CRP
322 periodontitis 9.2 TIMP1 MMP9 MMP1 CRP
323 diverticulitis 9.2 MMP9 CRP
324 carotid stenosis 9.1 SELP MMP9 MMP1 CRP
325 takayasu arteritis 9.0 VWF VCAM1 MMP9 CRP
326 atrial fibrillation 9.0 VWF SELP PLAT F2 CRP
327 intermittent claudication 9.0 VWF SERPINE1 SELP F2 CRP
328 pre-eclampsia 8.9 VWF VCAM1 SERPINE1 SELP ICAM1 F2
329 diabetes mellitus, noninsulin-dependent 8.9 VWF VCAM1 SERPINE1 PLAT CRP
330 dilated cardiomyopathy 8.7 VCAM1 TIMP1 MMP9 MMP1 CRP
331 stroke, ischemic 8.7 VWF SERPINE1 SELP PLAT F2 CRP
332 acute myocardial infarction 8.5 VWF SERPINE1 SELP PLAT MMP9 CRP
333 asthma 8.5 VCAM1 SELP SELL MMP9 MMP1 ICAM1
334 rheumatoid arthritis 8.4 VCAM1 TIMP1 MMP9 MMP1 ICAM1 CRP
335 heart disease 8.3 VWF SERPINE1 SELP PLAT ICAM1 F2
336 malaria 8.2 VWF VCAM1 SELP MMP9 ICAM1 CRP
337 arteries, anomalies of 7.7 VWF VCAM1 SERPINE1 SELP PLAT MMP9
338 myocardial infarction 7.3 VWF TIMP1 SERPINE1 SELP SELL PLAT

Comorbidity relations with Venous Insufficiency via Phenotypic Disease Network (PDN): (showing 20, show less)


Acute Cystitis Aortic Valve Disease 1
Bronchitis Chronic Pulmonary Heart Disease
Decubitus Ulcer Deficiency Anemia
Familial Atrial Fibrillation Femoral Vein Thrombophlebitis
Generalized Atherosclerosis Heart Disease
Hypertension, Essential Hypothyroidism
Iron Deficiency Anemia Mitral Valve Disease
Osteoporosis Peripheral Vascular Disease
Post-Thrombotic Syndrome Protein-Energy Malnutrition
Schizophreniform Disorder Tinea Pedis

Graphical network of the top 20 diseases related to Venous Insufficiency:



Diseases related to Venous Insufficiency
Sources

Symptoms & Phenotypes for Venous Insufficiency

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MGI Mouse Phenotypes related to Venous Insufficiency:

46 (showing 9, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.23 CRP F2 ICAM1 ITGA4 MMP9 PLAT
2 homeostasis/metabolism MP:0005376 10.15 CRP F2 ICAM1 MMP1 MMP9 PLAT
3 hematopoietic system MP:0005397 10.14 F2 ICAM1 ITGA4 MMP9 PLAT SELL
4 immune system MP:0005387 10.13 CRP F2 ICAM1 ITGA4 MMP1 MMP9
5 growth/size/body region MP:0005378 10.09 F2 ICAM1 MMP9 PLAT SELL SELP
6 mortality/aging MP:0010768 9.85 F2 ICAM1 ITGA4 MMP9 PLAT SELP
7 integument MP:0010771 9.8 F2 ICAM1 MMP9 PLAT SELL SELP
8 neoplasm MP:0002006 9.43 ICAM1 MMP1 MMP9 SELL SERPINE1 TIMP1
9 respiratory system MP:0005388 9.17 F2 MMP9 PLAT SELL SELP SERPINE1
Sources

Drugs & Therapeutics for Venous Insufficiency

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Drugs for Venous Insufficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 155, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hesperidin Approved, Investigational Phase 4 520-26-3 53477767
2
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
3
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
4
Racepinephrine Approved Phase 4 329-65-7 838
5
Glucosamine Approved, Investigational Phase 4 3416-24-8 439213
6
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
7
Serine Approved, Nutraceutical Phase 4 56-45-1 5951
8
Coumarin Experimental Phase 4 91-64-5 323
9
Troxerutin Investigational Phase 4 7085-55-4 5486699
10 Heparinoids Phase 4
11 Aminaftone Phase 4
12 Calcium, Dietary Phase 4
13 Rosuvastatin Calcium Phase 4 147098-20-2
14 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
15 Anticholesteremic Agents Phase 4
16 Central Nervous System Depressants Phase 4
17 Anesthetics, Local Phase 4
18 Antithrombin III Phase 4
19 HIV Protease Inhibitors Phase 4
20
protease inhibitors Phase 4
21 Serine Proteinase Inhibitors Phase 4
22 Antithrombins Phase 4
23 Factor Xa Inhibitors Phase 4
24 Neurotransmitter Agents Phase 4
25 Adrenergic Agents Phase 4
26 Anti-Arrhythmia Agents Phase 4
27 Sympathomimetics Phase 4
28 Sodium Channel Blockers Phase 4
29 Adrenergic Agonists Phase 4
30 Respiratory System Agents Phase 4
31 Adrenergic alpha-Agonists Phase 4
32 Adrenergic beta-Agonists Phase 4
33 Diuretics, Potassium Sparing Phase 4
34 Epinephryl borate Phase 4
35 Peripheral Nervous System Agents Phase 4
36 Mydriatics Phase 4
37 Anti-Asthmatic Agents Phase 4
38 Vasoconstrictor Agents Phase 4
39 Autonomic Agents Phase 4
40 Bronchodilator Agents Phase 4
41 Anticoagulants Phase 4
42 Fibrinolytic Agents Phase 4
43 Lipid Regulating Agents Phase 4
44 Hypolipidemic Agents Phase 4
45 Antimetabolites Phase 4
46 Glucuronyl glucosamine glycan sulfate Phase 4
47 Hypoglycemic Agents Phase 4
48
carbamide peroxide Approved Phase 2, Phase 3 124-43-6
49
Heparin Approved, Investigational Phase 3 9005-49-6 46507594 772
50
tannic acid Approved Phase 3 1401-55-4
51
Dalteparin Approved Phase 3 9005-49-6
52
Tinzaparin Approved Phase 3 9005-49-6, 9041-08-1 25244225
53
Benzocaine Approved, Investigational Phase 3 94-09-7, 1994-09-7 2337
54
Becaplermin Approved, Investigational Phase 3 165101-51-9
55
Prednisolone phosphate Approved, Vet_approved Phase 2, Phase 3 302-25-0
56
Methylprednisolone hemisuccinate Approved Phase 2, Phase 3 2921-57-5
57
Methylprednisolone Approved, Vet_approved Phase 2, Phase 3 83-43-2 6741
58
Zoledronic Acid Approved Phase 2, Phase 3 118072-93-8 68740
59
Prednisolone Approved, Vet_approved Phase 2, Phase 3 50-24-8 5755
60
Nitric Oxide Approved Phase 3 10102-43-9 145068
61
Thrombin Approved, Investigational Phase 3
62
Prednisolone hemisuccinate Experimental Phase 2, Phase 3 2920-86-7
63 Antioxidants Phase 3
64 Protective Agents Phase 2, Phase 3
65 Anti-Inflammatory Agents Phase 2, Phase 3
66 calcium heparin Phase 3
67 Tin Fluorides Phase 3
68 Hormones Phase 2, Phase 3
69 Gastrointestinal Agents Phase 2, Phase 3
70 Carboxymethylcellulose Sodium Phase 3
71 Heparin, Low-Molecular-Weight Phase 3
72 Mitogens Phase 3
73 Angiogenesis Modulating Agents Phase 3
74 Angiogenesis Inducing Agents Phase 3
75 Antiemetics Phase 2, Phase 3
76 Neuroprotective Agents Phase 2, Phase 3
77 glucocorticoids Phase 2, Phase 3
78 Methylprednisolone Acetate Phase 2, Phase 3
79 Diphosphonates Phase 2, Phase 3
80 Antineoplastic Agents, Hormonal Phase 2, Phase 3
81 Hormone Antagonists Phase 2, Phase 3
82 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
83 Prednisolone acetate Phase 2, Phase 3
84 Bone Density Conservation Agents Phase 2, Phase 3
85 Free Radical Scavengers Phase 3
86 Endothelium-Dependent Relaxing Factors Phase 3
87 Vasodilator Agents Phase 3
88 Hemostatics Phase 3
89 Coagulants Phase 3
90 Grape Approved Phase 2
91
Sodium citrate Approved, Investigational Phase 1, Phase 2 68-04-2
92
Timolol Approved Phase 2 26839-75-8 33624 5478
93
Methyl salicylate Approved, Vet_approved Phase 2 119-36-8 4133
94
Folic acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
95
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 2 65-23-6 1054
96
Citric acid Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 77-92-9 311
97
Quercetin Experimental, Investigational Phase 2 117-39-5 5280343
98
Horse chestnut Experimental Phase 2
99 Olive Phase 1, Phase 2
100 Omega 3 Fatty Acid Phase 1, Phase 2
101 Micronutrients Phase 2
102 Trace Elements Phase 2
103 Vitamins Phase 2
104 Vitamin B9 Phase 2
105 Folate Phase 2
106 Nutrients Phase 2
107 Vitamin B Complex Phase 2
108 Vitamin B 6 Phase 2
109 Butcher's Broom Phase 2
110 Citrate Phase 1, Phase 2
111 Antihypertensive Agents Phase 2
112 Adrenergic beta-Antagonists Phase 2
113 Adrenergic Antagonists Phase 2
114 Salicylates Phase 2
115 Antirheumatic Agents Phase 2
116
Pyridoxal Experimental, Nutraceutical Phase 2 66-72-8 1050
117
Iron Approved, Experimental 15438-31-0, 7439-89-6 23925 27284
118
Sulfadiazine Approved, Investigational, Vet_approved 68-35-9 5215
119
Pentoxifylline Approved, Investigational 6493-05-6 4740
120
Ticlopidine Approved 55142-85-3 5472
121
Aspirin Approved, Vet_approved 50-78-2 2244
122
Hyaluronic acid Approved, Vet_approved 9004-61-9 53477741
123
Silicon Approved, Investigational 7440-21-3 4082203
124
Copper Approved, Investigational 7440-50-8 27099
125
Warfarin Approved 81-81-2 6691 54678486
126
Polidocanol Approved 9002-92-0
127
Amikacin Approved, Investigational, Vet_approved 37517-28-5 37768
128
Teicoplanin Approved, Investigational 61036-62-2
129
Polihexanide Approved, Investigational 28757-47-3
130
Rivaroxaban Approved 366789-02-8
131 fluindione Approved, Investigational 957-56-2
132
Apixaban Approved 503612-47-3 10182969
133
Castor oil Approved, Investigational, Nutraceutical, Vet_approved 8001-79-4
134
Tribenoside Experimental 10310-32-4
135
Dabigatran Investigational 211914-51-1
136
Monensin Experimental, Vet_approved 17090-79-8
137 Castor
138 Antitubercular Agents
139 Anti-Inflammatory Agents, Non-Steroidal
140 Chlorhexidine gluconate
141 Antibodies
142 Immunoglobulins
143 Antibodies, Antiphospholipid
144 Antidotes
145 Anti-Bacterial Agents
146 Anti-Infective Agents, Local
147 Antibiotics, Antitubercular
148 Anti-Infective Agents
149 Complement System Proteins
150 Charcoal
151 Carbopol 940
152 Anesthetics, General
153 Cathartics
154 Laxatives
155 Analgesics

Interventional clinical trials:

(showing 229, show less)
# Name Status NCT ID Phase Drugs
1 A 6-week, Open, Multicentre Safety Trial to Evaluate the Tolerability Profile of Antistax® Film Coated Tablets (Extr. Vitis Viniferae Siccum), 360 mg/Day Per os, in Male and Female Patients Suffering From Chronic Venous Insufficiency Completed NCT02184234 Phase 4 Antistax film coated tablets
2 Evaluate the Efficacy and Safety of Esarin Gel in the Treatment of Chronic Venous Insufficiency or Varicose Vein Combine With Superficial Vein Thrombophlebitis in Outpatient Completed NCT02346058 Phase 4 Esarin Gel
3 The Fate Of Calf Perforators After Endovenous Laser Ablation Of Saphenous Veins Completed NCT01458795 Phase 4
4 Multicenter, Prospective, Randomized, Double-Blind Study to Assess the Therapeutic Efficacy and Safety of the Use of Venocur Triplex® in Patients With Chronic Venous Insufficiency Completed NCT00835822 Phase 4 Venocur Triplex®;placebo
5 Gliding Aids for Medical Compression Stockings - Practicability in Elderly Patients With Chronic Venous Insufficiency Completed NCT01432795 Phase 4
6 Evaluation of Efficacy and Safety of the Fixed-dose Combination of Coumarin and Troxerutin (Venalot®) Versus Placebo in the Symptomatic Treatment of Chronic Venous Insufficiency - VENACT Completed NCT01848210 Phase 4 Coumarin/troxerutin;Placebo
7 Randomized Double-blind Trial Between Clinical and Endovascular Treatment in Patients With Advanced Chronic Venous Insufficiency and Iliac Venous Obstruction Completed NCT02149212 Phase 4 Phlebotonic
8 Clinical Non-inferiority Study Between Diosmin 600 mg Tablets and Diosmin 900 mg + Hesperidin 100 mg Tablets in Symptomatic Chronic Venous Insufficiency After 6 Months of Treatment: Single-blind, Randomized, Parallel Group Study Completed NCT03471910 Phase 4 Diosmin;Diosmin / Hesperidin
9 SocknLeg - a User Friendly Medical Compression Study of a Modified Application of a Medical Device Completed NCT02621632 Phase 4
10 The Effect of Neuromuscular Electrical Therapy on Pain in Patients With Venous Ulcers: a Controlled Clinical Trial Completed NCT01372020 Phase 4
11 Radiofrequency Ablation vs Laser Ablation of the Incompetent Greater Saphenous Vein: A Prospective Randomized Trial Completed NCT02236338 Phase 4
12 A Pilot Trial of the Use of ReCell® Autologous Cell Harvesting Device for Venous Leg Ulcers Completed NCT01743053 Phase 4
13 Polidocanol Versus Glucose For Sclerotherapy Treatment Of Telangiectasia Of The Lower Limbs: Protocol For A Randomized, Controlled Clinical Trial Completed NCT02657252 Phase 4 Glucose;Polidocanol with Glucose
14 A Randomized Triple-blind Study Protocol Comparing Polidocanol Versus Hypertonic Glucose for Sclerotherapy in Treatment of Reticular Veins at the Lower Limbs. Completed NCT02054325 Phase 4 Polidocanol with Glucose;Glucose
15 Role of Statin in Venous Dysfunction in Patients With Venous Thromboembolism Event Recruiting NCT03988101 Phase 4 Rosuvastatin 20mg;Control
16 The Efficacy of Rivaroxaban With Diosmine in the Long-term Treatment of Acute Proximal Deep Vein Thrombosis Active, not recruiting NCT03413618 Phase 4 Rivaroxaban;Diosmin
17 A Randomised Clinical Trial Comparing Endovenous Laser Ablation and Mechanochemical Ablation (ClariVein®) in the Management of Superficial Venous Insufficiency Active, not recruiting NCT02627846 Phase 4 Lidocaine with 1:200,000 epinephrine solution;Lidocaine with 1:200,000 epinephrine solution;Sodium Bicarbonate;Sodium Tetradecyl Sulphate
18 Study of Antiinflammatory Effects of Detralex (Daflon) in Patients With Chronic Venous Disease Enrolling by invitation NCT01654016 Phase 4 Detralex
19 Radiofrequency Ablation vs. Laser Ablation of the Incompetent Small Saphenous Vein: A Prospective Randomized Trial Terminated NCT02248740 Phase 4
20 Prospective Evaluation of the Quality of Life of Patients With Post-thrombotic Syndrome Who Receive Compression Therapy and Sulodexide — SQUARES Study Terminated NCT02512601 Phase 4 Sulodexide
21 A Randomized Trial of the Flexitouch Compression System as an Adjunctive Treatment for Venous Stasis Ulcer Terminated NCT00534937 Phase 4
22 A Randomised Clinical Trial Comparing Standard Cannula Delivered Foam Sclerotherapy, Catheter Directed Foam Sclerotherapy and ClariVein® Mechanochemical Ablation in the Management of Superficial Venous Insufficiency. Withdrawn NCT02010437 Phase 4 Sodium Tetradecyl Sulphate (STS)
23 A Clinical Multicenter, Phase III, Prospective, Randomized, Double-blind, Comparative Study to Evaluate the Efficacy and Tolerability of Venaflon Use in Reducing the Symptoms Caused by Chronic Venous Insufficiency When Compared With Daflon Unknown status NCT01477281 Phase 3 Daflon;Venaflon (Diosmin and Hesperidin)
24 Study Clinical, Multicenter,Phase III,Prospective,Randomized,Comparative Double Blind/Double-dummy to Assess the Efficacy and Tolerability of the Use of Varicell in Reducing the Symptoms Caused by Chronic Venous Insufficiency and Hemorrhoidal Syndrome When Compared With Daflon Unknown status NCT01321619 Phase 3 Daflon;Varicell placebo
25 Comparative Efficacy of Two Preparations of the Association Diosmin (450 mg) + Hesperidin (50 mg) in the Treatment of Chronic Venous Insufficiency (CVI) Unknown status NCT01110512 Phase 3 Flavonid;Daflon
26 A Comparative Study to Assess the Efficacy and Safety of Endolex Forte vs Diosmin and Hesperidin in Reducing the symptomatoLogy of Patients With ChronIc VeNous Insufficiency Between Functional Classes CEAP 1-4, During a Period of 6 Months Unknown status NCT02927483 Phase 3
27 A Prospective, Multi-Centre, Double Blind, Randomized, Placebo Controlled Trial to Evaluate the Safety and Efficacy of ICXP007 in a Phase III Trial With Four-Layer Therapeutic Compression, for the Treatment of Non-Infected Skin Leg Ulcers, Due to Venous-Insufficiency Unknown status NCT00232973 Phase 3 ICXP007
28 Efficacy of Autologous Platelet-Rich Plasma in the Treatment of Vascular Ulcers in Primary Care: Clinical Trial Phase III Unknown status NCT02213952 Phase 3 Platelet-Rich Plasma
29 Randomized Single Center Comparative Study of the Treatment of Insufficient Greater Saphenous Vein: Surgery vs Ultrasound Guided Sclerotherapy With Foam and Endovenous Laser Therapy Unknown status NCT00529672 Phase 3
30 A 12-week, Double-blind, Randomised, Placebo-controlled, Multicentre Trial to Evaluate Efficacy and Tolerability of Antistax Film-coated Tablets, 360 mg/Day Orally, in Male and Female Patients Suffering From Chronic Venous Insufficiency. Completed NCT00292435 Phase 3 Read vine leaf extract (AS 195)
31 A 12-week, Double-blind, Randomised, Placebo-controlled, Multicentre Trial to Evaluate Efficacy and Tolerability of Antistax® Film Coated Tablets, 360 mg/Day Orally, in Male and Female Patients Suffering From Chronic Venous Insufficiency Completed NCT02191254 Phase 3 Antistax®;Placebo
32 Prospective, Randomized and Explorative Controlled Study About Influences of Compression Stockings on Skin's Barrier Function at Patients With Chronic Venous Insufficiency Completed NCT00196443 Phase 2, Phase 3
33 A 12-week, Double-blind, Randomised, Placebo-controlled, Multicentre Trial to Evaluate Efficacy and Tolerability of Antistax® Film Coated Tablets, 720 mg/Day Orally, in Male and Female Patients Suffering From Chronic Venous Insufficiency Completed NCT00855179 Phase 3 Red vine leaf extract (AS 195);Placebo
34 Clinical Study of BNS003 on Swelling Due to Disorder of Leg Venous Reflux Completed NCT02211898 Phase 3 BNS003
35 Evaluation of the Efficacy of Spa Treatment for Prevention of Leg Ulcers in Advanced Chronic Venous Insufficiency. Completed NCT00838500 Phase 3 Immediate spa treatment;Late spa treatment
36 Crenobalneotherapy in the Treatment of Chronic Venous Insufficiency. A Randomized Clinical Trial. Completed NCT01956318 Phase 3
37 Efficacy on Volume Reduction and Tolerance of Progressiv' Medical Compressive Therapy (MCT) V0322 BC in Patients With Chronic Venous Oedema. International, Multicentric, Randomised, Controlled, Double Blind Study, in Two Parallel Groups v0322 bc Versus Placebo Completed NCT01402921 Phase 3
38 Treatment of Greater Saphenous Vein (GSV) Insufficiency Using Echo-Guided Sclerotherapy With Lauromacrogol 400 Foam –Comparative Study of 3% Versus 1% Concentration. Completed NCT00348764 Phase 3 lauromacrogol
39 Deep Venous Thrombosis. Long-Term Results After Treatment With Either Low-Molecular -Weight Heparin or Unfractionated Heparin. Examinations of the Venous System. Completed NCT00628576 Phase 3 unfractionated heparin;Tinzaparin (Leo)
40 A Phase 3 Randomized, Double Blind, Vehicle Controlled Study Investigating the Safety and Efficacy of HP802-247 in the Treatment of Venous Leg Ulcers >12 cm2 to ≤ 36 cm2 Completed NCT01737762 Phase 3
41 Double Blind Randomized Controlled Trial of Recombinant Human Platelet Derived Growth Factor-BB Gel (Regranex Gel®) Versus Hydrogel (Duoderm Hydrogel®) for Healing of MARTORELL's Hypertensive Leg Ulcers. ERAN Trial. Completed NCT00970697 Phase 3 becaplermin gel;Duoderm Hydrogel™
42 Zoledronic Acid or Methylprednisolone in the Management of Active Charcot's Neuroarthropathy of Foot in Patients With Diabetes Mellitus: A Randomized, Double-blind, Placebo Controlled Trial Completed NCT03289338 Phase 2, Phase 3 Zoledronic Acid;Methylprednisolone;Placebos
43 Double Blind, Randomized, Placebo Controlled Clinical Trial for the Treatment of Diabetic Foot Ulcers, Using a Nitric Oxide Releasing Patch: PATHON Completed NCT00428727 Phase 3 Controlled nitric oxide releasing patch;placebo patch
44 The MUFFIN-PTS Trial: Micronized Purified Flavonoid Fraction for the Treatment of Post-Thrombotic Syndrome Not yet recruiting NCT03833024 Phase 3 Micronized Purified Flavonoid Fraction;Placebo
45 A Phase 3 Randomized Safety and Efficacy Trial of HP802-247 in the Treatment of Chronic Venous Leg Ulcers (EU) Terminated NCT01853384 Phase 3
46 Clinical Evaluation of the Safety and Effectiveness of Topical Autologous Platelet Gel (APG) for the Treatment of Lower Extremity Chronic Venous Insufficiency Ulcers. A Multicenter, Randomized, Controlled Clinical Trial Withdrawn NCT00273234 Phase 3
47 Endovenous Treatment of the Saphenous Vein With Biolitec 1470nm Laser Versus Vnus Closure Fast Unknown status NCT01972633 Phase 1, Phase 2
48 Phase 1 and 2 Study on the Efficacy and Side Effects of Olive Oil and Omega 3 Local Treatment in Stasis Dermatitis Unknown status NCT00421161 Phase 1, Phase 2 olive oil and omega 3 in a combined cream
49 A Prospective Double Blind Randomized Controlled Trial Of Electrocoagulation Versus Radiofrequency Treatment Of The Great Saphenous Vein In Patients With Varicose Veins. Unknown status NCT02139085 Phase 2
50 Efficacy Study of a Peristaltic Pulse Pneumatic Device in the Treatment of Claudication Unknown status NCT01007604 Phase 2
51 NON-HEALING ULCERS WITHOUT CRITICAL LIMB ISCHEMIA (NEWLI-Trial): A Single Center Pilot Trial on the Efficacy of an Endovascular Approach for Treatment of Non-healing Lower Limb Ulcers in Patients Presenting With a Mild to Moderate Peripheral Artery Disease Unknown status NCT01666093 Phase 2
52 An Open-label, Non-randomized, Phase I/II Study of Allogeneic Human Umbilical Cord Tissue-Derived Mesenchymal Stem Cells (UC-MSC) and Liberation Therapy (When Associated With Chronic Cerebrovascular Venous Insufficiency) in Patients With Relapsing Remitting Multiple Sclerosis (RRMS) Unknown status NCT02587715 Phase 1, Phase 2
53 A Phase II Randomized Study to Evaluate the Safety of the Compression Test Device Using Intermittent Pneumatic Compression Mode in Subjects With Venous Insufficiency and Oedema Completed NCT00732823 Phase 2
54 The Ability of Antistax® to Improve Chronic Venous Insufficiency (CVI) I and II in Male and Female Patients: a Dose Response Study Completed NCT02191280 Phase 2 Antistax®, low dose;Antistax®, high dose;Placebo
55 A 17 Week, Randomised, Double-blind, Placebo Controlled Cross-over Trial to Evaluate the Efficacy of Antistax® Film Coated Tablets (Extr. Vitis Vinifera Siccum), 360 mg/Day p.o. in Improving Microcirculation of the Skin in the Leg of Male and Female Patients Suffering From Chronic Venous Insufficiency Completed NCT02191163 Phase 2 Antistax®;Placebo
56 Endovascular Correction of Chronic Cerebrospinal Venous Insufficiency (CCSVI) and Evaluation of Influence of These Treatments on the Symptoms of Multiple Sclerosis Completed NCT01264848 Phase 1, Phase 2
57 Physical Conditioning in Management of Chronic Venous Insufficiency Completed NCT00013273 Phase 2
58 Evaluation of DermStream(tm) - an Irrigation Product for Chronic Wound Management Completed NCT00310752 Phase 1, Phase 2
59 Phase I/II Interventional Clinical Trial of Balloon Venoplasty for Chronic Cerebrospinal Venous Insufficiency in Multiple Sclerosis Patients Completed NCT01864941 Phase 1, Phase 2
60 A Randomized, Parallel Group, Controlled Study to Assess the Efficacy and Safety of NMBM in the Treatment of Subjects With a Post-cellulitis and Venous Leg Ulcer Completed NCT01770509 Phase 1, Phase 2
61 The Efficacy of Red Vine Leaf Extract, Butcher's Broom, Horse Chestnut and Vitamin B6 on the Quality of Life in Females With Chronic Venous Insufficiency Completed NCT02498327 Phase 2
62 The Efficacy of Red Vine Leaf Extract, Butcher's Broom, Horse Chestnut and Vitamin B6 in the Treatment of Symptoms Associated With Chronic Venous Insufficiency Completed NCT02483962 Phase 2
63 Topical Timolol Benefit in Venous Ulcers Completed NCT02422017 Phase 2 Timolol
64 A Randomized, Double-Blind, Placebo-Controlled, Dose-Response Study of the Safety and Efficacy of Thymosin Beta 4 in the Treatment of Patients With Venous Stasis Ulcers Completed NCT00832091 Phase 2 Thymosin Beta 4;Placebo
65 Preventing Venous Leg Ulcers With Cryotherapy: A Randomized Clinical Trial Completed NCT01509599 Phase 1, Phase 2
66 Feasibility and Safety and Evaluation of the Potential Efficacy of Autologous Platelet-rich Plasma in the Treatment of Vascular Venous Ulcers Compared to Moist Wound Care in a Primary Care Setting Completed NCT01817218 Phase 1, Phase 2 Platelet Rich Plasma
67 Micro-mobile Foot Compression Device to Improve Motor-function in People With Diabetes and Loss of Protective Sensation Completed NCT03135535 Phase 2
68 Safety and Efficacy Study for the Use of Extracorporeal Shockwaves in the Treatment of Chronic Soft Tissue Wounds Completed NCT00545896 Phase 2
69 An Open Label Multicenter Safety Study of the Varisolve® Procedure for the Treatment of Varicose Veins in Patients With Right-to-left Cardiac Shunt Completed NCT00442364 Phase 2 Polidocanol (1%) Microfoam (Varisolve)
70 Community Randomised Control Trial of the Effectiveness of Two Compression Bandaging Technologies Completed NCT00202267 Phase 2
71 A Prospective, Randomized, Controlled, Multi-Center, Double Blind Study of ClariVein RES for Treatment of Venous Insufficiency Associated With Incompetent Saphenous Veins Due to Superficial Venous Reflux Recruiting NCT03311269 Phase 2 Sodium Tetradecyl Sulfate 1% Injection;Sodium Tetradecyl Sulfate 3% Injection
72 Efficacy of TR 987, Beta-1,3-1,6-D-glucan, in the Treatment of Chronic Venous Insufficiency Ulcers: a Two-arm, Double-blind, Placebo-controlled, Randomized Controlled Trial. Recruiting NCT03154619 Phase 2 0.1% TR 987;Placebo gel
73 Novel Offloading for Diabetic Foot Ulcers With PulseFlow: A Prospective Study Recruiting NCT02783066 Phase 2
74 Monitoring and Managing Newly Healed Chronic Leg and Foot Ulcer Skin Temperature: A Cooling Intervention (MUSTCOOL) to Prevent Ulcer Recurrence Recruiting NCT02626156 Phase 2
75 A PRELIMINARY OPEN CLINICAL STUDY, TO ASSESS THE SAFETY AND EFFICACY OF RPh201 APPLIED TOPICALLY FOR THE TREATMENT OF HARD TO HEAL CHRONIC ULCERATED WOUNDS Terminated NCT01429519 Phase 1, Phase 2 RPh201, botanical drug product
76 An Open-label, Non-randomized, Phase I/II Study of Allogeneic Human Umbilical Cord Tissue-Derived Mesenchymal Stem Cells (UC-MSC) and Liberation Therapy (When Associated With Chronic Cerebrovascular Venous Insufficiency) in Patients With Relapsing Remitting Multiple Sclerosis (RRMS) Terminated NCT02418325 Phase 1, Phase 2
77 A Phase 1a, Open Label, Single Dose, Dose Response, Pilot Study to Evaluate the Safety and Tolerability of Human Fibroblast Growth Factor-1 (FGF-1) in Normal Volunteers Given Punch Skin Biopsies Unknown status NCT00916292 Phase 1 FGF-1 141;FGF-1 141
78 Study on the Effect of Kinesio Taping on Bioelectrical Activity of Gastrocnemius Muscles and Range of Ankle Motion in Post-menopausal Women With Chronic Venous Insufficiency Completed NCT01501188 Phase 1
79 Deep Diabetic Foot Wound Treatment With Hydrogel Including 3% Sodium Pentaborate Pentahydrate Recruiting NCT02241811 Phase 1 3% Sodium Pentaborate Pentahydrate;Placebo
80 Phase I Open-label, First-in-human Study to Evaluate Feasibility and Safety of Tissue Engineered Veins in Patients With Chronic Venous Insufficiency Not yet recruiting NCT03784131 Phase 1 P-TEV
81 The Clinical Research of Surgery on Primary Chronic Venous Insufficiency Unknown status NCT00931424
82 Compliance of Compression Therapy in Healed Venous Ulcerations Unknown status NCT01680809
83 REVITIVE for the Treatment of Patients With Venous Insufficiency Unknown status NCT02114307
84 A Confirmatory Study to Evaluate the Safety and Efficacy of Cryopreserved Bilayered Cellular Matrix (ORCEL) for the Treatment of Venous Ulcers Unknown status NCT00270972
85 Venous Pressure Measurement of the Great Saphenous Vein Using Controlled Compression Ultrasound in Healthy Persons and Patients With Chronic Venous Disease as a New Non Invasive Method for Investigation of the Pathophysiology in Primary Varicose Veins Unknown status NCT01000909
86 Safety and Primary Efficacy of the External Synchronized Vein Valve (ESVV) in Treatment of Chronic Venous Insufficiency (CVI) Sequel - A Pilot Study Unknown status NCT01346553
87 Venous Obstruction in Neurodegenerative Disorders Research Registry Unknown status NCT01593358
88 3-4 Year Outcomes Following Endovenous Steam Ablation of the Saphenous Veins for the Treatment of Venous Insufficiency Unknown status NCT02944331
89 Prospective Multicentric Randomised Trial Between Radiofrequency Ablation With VNUS Closure Fast ® and Endovenous Ablation With 1470 nm Diod Laser and Tulip Fiber ® for Treatment of Primary Venous Insufficiency. Unknown status NCT01722019
90 Prospective, Single-arm, Single Center, Pilot Study of Vascular Ultrasound Imaging Used as an Adjunct to Intravascular Ultrasound for Diagnosing Iliac Vein Obstruction Unknown status NCT02240914
91 Aqua Therapy to Lower Adverse and Negative Effects of Deep Vein ThrombosIs and Post Thrombotic Syndrome Unknown status NCT02553720
92 Radiographic and Intravascular (IVUS) Evaluation of Venous Morphology During CCSVI Treatment Unknown status NCT01593891
93 Development and Validation of a Limb Volumetry Technique Applicable in Daily Clinical Practice Using Self Positioning 3D Laser Scanning:Reproductibility and Comparison to the Reference Method Unknown status NCT01574911
94 Clinical Trial : Terminal Axial Perforator Interruption Reflux Source (TAPIRS ) Plus Adjustable Compression System in Treatment of Venous Leg Ulcers Versus Multilayer Bandage Treatment Unknown status NCT02798445
95 Color Doppler U/S vs MSCT Venography in the Diagnosis of May-Thurner Syndrome Unknown status NCT03262987
96 Local Endogenous Biomarkers in the Later Stages of Chronic Venous Disease Versus Controls During Gravitational Stress, Prolonged Elevation Recovery and Compression Unknown status NCT02662127
97 Vascular Abnormalities in Idiopathic Parkinson's Disease Unknown status NCT02045420
98 Study to Evaluate Polyheal-1 in Treatment of Recalcitrant Wounds Unknown status NCT00552643
99 Randomized Clinical Trial to Determinate the Effectiveness and Safety of Plasma Rich Growth Factors (PRGF) in Venous Ulcers Treatment Unknown status NCT01491438
100 Non-Invasive Management of Chronic Venous Insufficiency Completed NCT00950378
101 Manual Lymphatic Drainage in Chronic Venous Insufficiency: a Randomized Controlled Trial Completed NCT01899482
102 The Effects of Compression Stockings on Pressure Parameters in Patients With Chronic Venous Insufficiency Completed NCT01558024
103 Transient Elastography DEdicated to Cosmetology And Dermatology (TEDECAD) Completed NCT02061254
104 Doppler Sonography, Magnetic Resonance Venography, Air-plethysmography in the Non-invasive Diagnostics of Chronic Cerebrospinal Venous Insufficiency (CCSVI) Completed NCT01425554
105 Evaluation of a Dual Action Pneumatic Compression Device: Patient Ease of Use and Comfort Completed NCT02015221
106 The Effectiveness of Exercise Training in Venous Insufficiency Completed NCT03755180
107 Single Center Prospective Study Evaluating the Safety of Progressive Compressive Stockings for the Treatment of Venous Insufficiency in Patients With Peripheral Arterial Disease Completed NCT02431819
108 Preventing the Development of Venous Insufficiency in Pregnant Women Through Use of Compression Stockings: A Randomized Pilot Study Completed NCT01793194
109 Obtaining and Storing Blood Samples and Debridement Samples for Wound Related Research Completed NCT00762697
110 The Sapheon Closure System Feasibility Study Completed NCT01603433
111 Dosing of Electrical Stimulation in Venous Insufficiency Completed NCT03850496
112 New Combined Laser Therapy in Patients With Trophic Ulcers of Lower Extremities and Chronic Venous Insufficiency Completed NCT03104985
113 Comparative Randomized Clinical Study to Evaluate the Efficacy of Radiofrequency vs Surgical Technique of Internal Saphenous Vein Stripping and CHIVA Technique in the Treatment of Chronic Venous Insufficiency. Completed NCT02454452
114 A Comparison of the Party Balloon Assisted Valsalva With Conventional Valsalva Maneuver in Diagnosis of Superficial Venous Valvular Reflux of Lower Limb Completed NCT02051439
115 IN-BALANCE VLU Inflammation, Bacteria, & Angiogenesis Effects in Launching Venous Leg Ulcer Healing Completed NCT01549860
116 Vascular Fundus Changes in Patients With High Probability of CCSVI (Chronic Cerebrospinal Venous Insufficiency) Completed NCT01356134
117 The Utility of Novel Ambulatory Treatment Techniques in Venous Insufficiency Completed NCT01298908
118 Fibered Platinum Coils vs Vascular Plugs in Pelvic Varices Embolization for the Treatment of Pelvic Congestion Syndrome Completed NCT02796092
119 Lake Washington Vascular VenaSeal™ Post-Market Evaluation: WAVES Completed NCT02585726
120 Cross-Sectional Population Based Study on Prevalence and Risk Factors for Chronic Venous Disease in General Population Completed NCT03900234
121 A Retrospective Analysis of Patients With Full Thickness Wounds in Limbs With Critical Ischemia Completed NCT00760357
122 Safety and Wound Healing Efficacy of the TalidermR Wound Dressing a Poly-N-acetyl Glucosamine-derived Membrane Material in Humans With Venous Stasis Ulcers: a Pilot Study. Completed NCT00720239 Early Phase 1
123 Clinical Aspect of Erosive Pustular Dermatosis of the Leg Completed NCT03623191
124 Post Market Study - "European Observational Study of the Sapheon™ Closure System for the Definitive Treatment of Incompetent Great Saphenous Veins: A Prospective Single Arm Multicenter Clinical Observational Study" Completed NCT01570101
125 SOCKNLEG Compression Stocking Kit User Friendliness: Donning-Doffing-Edema Prevention An Open Monocentric Randomized Controlled Cross-over Trial Completed NCT03429959
126 Randomized Multi-centered Study for Evaluating the Efficacy and Safety of Angioplastic Surgery of the Extracranial Veins in the Treatment of Multiple Sclerosis. Studio Randomizzato Multicentrico Per la Valutazione Dell'Efficacia e Sicurezza Dell'Intervento di Disostruzione Delle Vene Extracraniche Nel Trattamento Della Sclerosi Multipla Completed NCT01371760
127 Effectiveness of a Pressure Indicator Guided and a Conventional Bandaging in Treatment of Venous Leg Ulcer Completed NCT02729688
128 Evaluation of a Dual Action Pneumatic Compression Device: Patient Ease of Use and Comfort in Patients With Venous Leg Ulcers Completed NCT02395302
129 Intermittent, Gradient, Pneumatic Compression Plus Standard Compression for Hard-To-Heal Venous Ulcers in Subjects With Secondary Lymphedema and Chronic Venous Insufficiency Completed NCT01079299
130 Chronic Venous Insufficiency; Impact of Compression Stockings on Quality of Life Completed NCT02050061
131 Feasibility, Efficacy, and Safety of Venous Ulcer Treatment Using a Hand Plasma Generator (PlasmaDerm) Chronisch venöser Ulzerationen (PlasmaDerm) Completed NCT01415622
132 Venous Insufficiency and Neuromuscular Stimulation Completed NCT02137499
133 Compression Therapy Versus Surgery in the Treatment of Superficial Venous Reflux - A Randomized Controlled Trial Completed NCT01701661
134 Prevalence of Chronic Cerebrospinal Venous Insufficiency in Patients With Multiple Sclerosis and Other Neurological Diseases. An Ultrasound, Blinded, Case-Controlled, Centralized Reading Assessment Completed NCT02308579
135 Evaluation of Electrocardiographic Guidance in Accurate Peripherally Inserted Central Catheter Placement in Children. Completed NCT02324504
136 LivRelief Varicose Veins Cream in the Treatment of Chronic Venous Insufficiency of the Lower Limbs: A 6-week Single Arm Pilot Study Completed NCT03653793
137 Incidence and Progression of Peripheral Venous Disease Completed NCT00508079
138 Randomised Trial of Radiofrequency Ablation vs Conventional Surgery for Superficial Venous Insufficiency: if You Don't Tell, They Won't Know Completed NCT02588911
139 A Dual Centre, Randomised Controlled Trial of the Clinical and Cost Effectiveness of Endovenous Laser Therapy (EVLT) in the Treatment of Varicose Veins and Venous Ulcers Completed NCT00759434
140 A Prospective Epidemiological Multicenter Cohort Study on Patients Clinically Suspected of Deep Vein Thrombosis or Pulmonary Embolism Completed NCT00670540
141 Association of Thrombophilia and Inflammation With Post-Thrombotic Syndrome Completed NCT00395265
142 Optimal Intensity and Frequency of a Portable Electrical Muscle Stimulator (VeinoPlus) to Improve Symptoms of Postthrombotic Syndrome Completed NCT00858130
143 Open Label Clinical Study to Assess the Clinical Safety of a New Compression Procedure in Subjects With Peripheral Arterial Vascular Disease Completed NCT00854516
144 Prevalence of Onychodystrophy in Patients With Chronic Venous Disease of the Lower Limbs Completed NCT02731222
145 Randomized Clinical Trial of Routine Preoperative Duplex Imaging Before Varicose Vein Surgery; Long-term Follow-up Completed NCT01195623
146 Carbon Dioxide Infusion:Clinical and Histological Appraisal in Chronic Wounds Completed NCT01864967
147 Cryotherapy for Chronic Venous Disorders Completed NCT00617825
148 Safety and Efficacy of Endovenous Laser Ablation for the Resolution of Incompetent Perforator Veins The RELIEVE Study Completed NCT00565604
149 Prospective Evaluation of the Interest of a Systematic Biopsy for Hard-to-heal Leg Ulcers Completed NCT00709631
150 Prospective Random Study for Handling Venous Ulcer With Conservative Treatment (Dressings Alone) and Foam Sclerotherapy Versus Conservative Treatment Completed NCT01594658
151 Head Circumference Growth in Children With Ehlers-Danlos Syndrome Who Develop Dysautonomia ("POTS" -- Postural Orthostatic Tachycardia Syndrome)Later in Life -- a Retrospective Analysis Completed NCT01367977
152 Impact of Copper Compression Stockings on Venous Insufficiency and Lipodermatosclerosis: a Randomised Controlled Trial Completed NCT03283800
153 Prospective Interventional Study Investigating the Effect of Renal Transplantation on Obstructive Sleep Apnea and Its Correlation to Nocturnal Rostral Fluid Shift, in End Stage Renal Disease Patients Completed NCT02020642
154 The Prevalence of Post-Thrombotic Syndrome in Deep-Vein Thrombosis (DVT) Patients Treated With Dabigatran- a Cross-Sectional Assessment of RE-COVER Study Patients Completed NCT03050138
155 Effect of Intermittent Hemodialysis on Sleep Apnea Syndrome and Its Correlation to Nocturnal Rostral Fluid Shift, in End Stage Renal Disease Patients Completed NCT01860209
156 Blood Flow and Bone Density in Healthy Adult Women Completed NCT00397462
157 Diosmiplex (Vasculera®) in Primary and Secondary Raynaud's Phenomenon Completed NCT02683408
158 Observational Study of the Prevalence of CCSVI in Multiple Sclerosis and in Other Neurodegenerative Diseases Completed NCT01384825
159 The Effect of Compression Stockings on Cerebral Desaturation Events in Obese Patients Undergoing Shoulder Arthroscopy in the Beach Chair Position Completed NCT01996813
160 Impact of V.A.C. Veraflo Therapy in Wounds Requiring Debridement Within an Orthopedic Practice Completed NCT02266771
161 A Prospective, Randomized, Controlled Clinical Study to Evaluate the Effectiveness of a Cellulose Matrix Wound Dressing for Autolytic Debridement and Healing of Chronic Venous Ulcers Completed NCT00446823
162 State-of-the Art Treatment of Chronic Leg Ulcers: a Randomised Controlled Trial Comparing Vacuum Assisted Closure (V.A.C.®) With Modern Wound Dressings Completed NCT00243620
163 Quadrivas Therapy® to Reduce Lipedema Subcutaneous Adipose Tissue (QUADRIVAS) Completed NCT02907411
164 Non-invasive Measurement of Microvascular Blood Flow During Mild External Compression of the Leg Completed NCT01804478
165 Activated Carbon Interphase Effect on Biofilm and Total Bacterial Load: A Randomized Pilot Study Completed NCT03461783
166 Multi-Screen Electronic Alert for Venous Thromboembolism Prevention Completed NCT00550082
167 Observational Study of the Effect of VarIthena® on Wound Healing in the Treatment of Venous Leg Ulcers Resulting From Chronic Venous Insufficiency Recruiting NCT03257254 Varithena
168 Investigation of Femoropopliteal In Situ Valve Formation With the InterVene System Recruiting NCT03216005
169 Lower Limb Venous Insufficiency and the Effect of Radiofrequency Treatment Versus Open Surgery. A 5-year Follow-up Using Duplex Ultrasound, Plethysmography, VCSS, AVVQ and EQ-5D Recruiting NCT02397226
170 VEINEX : Venous Investigations During Exercise Recruiting NCT02689557
171 Discovering the Effect of Venous Insufficiency on Nocturia (DEVINe - Trial) - Pilootstudie: definiëren Van Duidelijke Afkapwaarden Omtrent Oedeem Ter Hoogte Van de Onderste Ledematen te Gevolge Van Veneuze insufficiëntie. Recruiting NCT03928197
172 SOCKNLEG Leg Compression Stocking Kit: Physical Properties: Static Stiffness Index - Venous Ejection Fraction An Open Monocentric Randomized Controlled Cross-over Trial Recruiting NCT03743597
173 Venous Ulcer: Endovenous Radiofrequency Treatment of Insufficient Perforating and Saphenous Veins Versus Multilayer Compression Bandaging - Randomized Controlled Clinical Trial Recruiting NCT03293836
174 Immediate Versus Early Endovenous Ablation In Venous Ulcer Recruiting NCT03795064 Sodium Tetradecyl Sulfate
175 The Effect of Structured Exercise on Chronic Venous Insufficiency: A Feasibility Trial Recruiting NCT03562546
176 Non-elastic Compression Garment Therapy Versus Control for Deep Vein Thrombosis: A Bayesian Adaptive Randomized Trial Recruiting NCT03368313
177 Long Term Natural History of PTS and Other Adverse Outcomes After Venous Thromboembolism in the Optimev Study (SPOT) Recruiting NCT03054727
178 Volume Estimation of Lower Limbs Before and After Endovascular Venous Intervention or Conventional Surgery in Venous Disease Recruiting NCT03703765
179 Randomized Controlled Trial Comparing the Clinical Outcomes After Cyanoacrylate Closure and Surgical Stripping for Incompetent Saphenous Veins Recruiting NCT03835559
180 A Real World, Observational Registry of Chronic Wounds and Ulcers to Assess Quality of Care, Evidence Based Practice and Outcomes Using Linked Electronic Health Record Data Recruiting NCT02280733
181 Platelet Rich Fibrin in Combination With Topical Antibiotics or Antiseptics in the Treatment of Chronic Wounds - a Prospective, Randomized, Active Controlled, Double Blind Pilot Trial With an Observer-blinded Control Group Recruiting NCT02652169 PRF mixed with amikacin and teicoplanin;PRF mixed with PHMB plus Macrogolol;PRF plus normal saline
182 A Single Centre Open Label Study Measuring Microcirculatory Flux Using Speckle Imaging Device, in Patients With Arterial, Mixed and Diabetic Foot Ulcers Using gekoTM Neuromuscular Electrostimulation (NMES) Recruiting NCT03186560
183 Monitoring of Tissue Transfer Flaps by Modulated Imaging (MI) Spectroscopy Recruiting NCT00633503
184 Assessment of Tissue and Biomolecular Complements of Lower Limb Chronic Oedema Recruiting NCT02914808
185 A Randomised Controlled Trial of Compression Stockings Therapy Following Mechano-Chemical Ablation Recruiting NCT03685838
186 Chronic Venous Thrombosis: Relief With Adjunctive Catheter-Directed Therapy - The C-TRACT Trial Recruiting NCT03250247
187 The Difference in Wound Size Reduction Comparing Two Frequently Used Wound Dressings in Everyday Care - a Randomized Controlled Trail Recruiting NCT03596112
188 A Sham Controlled Study to Compare the Effectiveness of Three Different Power Levels of PEMF Devices in the Treatment and Resolution of Venous Stasis Leg Ulcers Recruiting NCT03416049
189 Multi-center Study on the Effectiveness of Treatment With a Blue Light Medical Device (EmoLED) in Reduction of the Ulcer Surface in 10 Weeks Recruiting NCT04018924
190 Pain in Patients With Chronic Leg and Foot Ulcers - a Cross Sectional Study Recruiting NCT03086577
191 A Single Center, Prospective, Double-blinded, Randomized, Placebo-controlled Trial Evaluating the Efficacy of Fractionated Carbon Dioxide Therapy in Postoperative Lower Extremity Wound Healing Recruiting NCT03644849
192 Pilot Randomised Controlled Trial Evaluating the Potential Benefit of a One Stop Vein Clinic (OSVeC) Recruiting NCT02557542 Foam sclerotherapy (Polidocanol or Sodium Tetradecyl Sulphate)
193 Open Label, Prospective Clinical Trial to Evaluate Impact on Quality of Life in Chronic Venous Insufficiency Patients Using SANKOM® Patent Socks During 4 Weeks Active, not recruiting NCT03445091
194 Prospective Safety and Effectiveness Study: VenaCure Endovenous Laser Treatment (EVLT) 400 µm Fiber Procedure Kit for Treatment of Incompetent Perforator Veins Active, not recruiting NCT02215369
195 A Randomised Controlled Trial of the Clinical and Cost Effectiveness of Endovenous Laser Therapy in the Treatment of Varicose Veins Secondary to Isolated Sapheno-Popliteal Incompetence and Short Saphenous Reflux Active, not recruiting NCT00841178
196 Randomized Trial Comparing a Dual Action Pneumatic Compression System Against Multi-Layer Bandaging Systems: A Non-inferiority Study Active, not recruiting NCT02680834
197 Multi-Centre Registry to Investigate the Efficacy and Safety of Venaseal Endovenous Ablation for Varicose Veins in Singapore Active, not recruiting NCT03893201
198 A Pilot Study to Evaluate the Feasibility and Potential Effectiveness of the Flexitouch System Head and Neck Treatment Active, not recruiting NCT03332160
199 A Prospective, Multi-Center, Randomized, Parallel-group Study Comparing AMNIOEXCEL Plus Placental Allograft Membrane to a Marketed Comparator and Standard of Care Procedures in the Management of Diabetic Foot Ulcers Active, not recruiting NCT03547635
200 Role of a Novel Exercise Program to Prevent Post-thrombotic Syndrome Active, not recruiting NCT02148029
201 Outpatient Office Based Endovascular Procedures Enrolling by invitation NCT04054440
202 Effect of Plasma Derived Exosomes on Intractable Cutaneous Wound Healing: Prospective Trial Enrolling by invitation NCT02565264 Early Phase 1
203 Venaseal Versus Ablation With Endothermal Laser or Radiofrequency for Saphenous Vein Incompetence: a Comparison of Utilization of Adjunctive Phlebectomy Enrolling by invitation NCT04006184
204 A Prospective Randomized Clinical Trial Comparing Multi-layer Bandage Compression Therapy With and Without a Biologically Active Human Skin Allograft for the Treatment of Chronic Venous Leg Ulcers Enrolling by invitation NCT03935386
205 A Prospective Randomized Comparative Parallel Study of Amniotic Membrane in the Management of Venous Leg Ulcerations Enrolling by invitation NCT02929056
206 The Effectiveness of Trans-catheter Foam Sclerotherapy of Pelvic and Atypical Lower Limb Varicosities Not yet recruiting NCT03652025
207 Cyanoacrylate Closure for Treatment of Venous Leg Ulcers Not yet recruiting NCT04011371
208 Ecchymosis and Coldness in Patients With Varicose Vein: Multicenter Study of Modified VEIN-Sym QoL Assessment Not yet recruiting NCT03384355
209 EdemaWear to Reduce Edema in Hospitalized Patients With Chronic Venous Insufficiency: A Pilot Study Not yet recruiting NCT03904602
210 A Comparative Evaluation of a Marine Polysaccharide Dressing and a Carboxymethylcellulose Dressing on Subjects With Lower Extremity Venous Ulcers Not yet recruiting NCT03903692
211 Genital Haemorrhage in Woman of Childbearing Age Treated for Venous Thromboembolism Disease : Comparison According to Oral Anticoagulant and Impact on Quality of Life. Not yet recruiting NCT03772366
212 Endovasculer Treatement of Male Pelvic Venous Insufficiency Not yet recruiting NCT03341897
213 Role of Intravascular Ultrasound(IVUS) in Management of Acute and Chronic Iliocaval Obstruction Not yet recruiting NCT04024215
214 Multi-center Registry for CCSVI Testing and Treatment Suspended NCT01205633
215 A Prospective Multicenter Study on the Treatment of Incompetent Perforators With the VNUS® Closure Radiofrequency Stylet Terminated NCT01079598
216 A Feasibility Study of the InterVene ReLeaf Catheter System in the Creation of Tissue Leaflets in the Femoral and/or Popliteal Vein Terminated NCT02462096
217 Utility of Chronic Cerebrospinal Venous Insufficiency Percutaneous Angioplasty for Multiple Sclerosis: The Albany Vascular Group Study (Liberation Study) Terminated NCT01089686
218 The Effectiveness of Endovascular Treatment of Chronic Cerebrospinal Venous Insufficiency (CCSVI) in Patients With Multiple Sclerosis Terminated NCT01201707
219 Treatment of Chronic Wounds Using Extracellular Matrix-Based Devices and the Patient's Own Blood Components Terminated NCT01909908
220 Evaluation of GORE VIABAHN Endoprosthesis With Heparin Bioactive Surface for the Treatment of Venous Occlusions and Stenoses Terminated NCT01406795
221 Evaluation of Perivascular Venous Vascularization and Inflammation by Contrast-enhanced Ultrasound (CEUS) in Patients With Acute Deep Vein Thrombosis and Superficial Thrombophlebitis - a Pilot Study Terminated NCT01367769
222 A Multi-center Randomized Open-Label Controlled Clinical Trial Evaluating Suction Blister Grafting Utilizing a Novel Harvesting Device (CelluTome©) and Standard of Care vs. Standard of Care Alone in the Treatment of Venous Leg Ulcers Terminated NCT02148302
223 Impact of 3-week SPA Therapy on Sleep Apnea in Patients With Obstructive Sleep Apnea Syndrome and Chronic Venous Insufficiency: A Randomized, Controlled Study Withdrawn NCT02559427
224 A Multi-Center, Randomized, Controlled Study to Evaluate the Efficacy and Safety of Subjects Comparing the NeverTouch Versus the RF ClosureFAST Methods of Treatment of the Great Saphenous Vein Withdrawn NCT01173419
225 The Effect of Percutaneous Venoplasty on Muscular Function, Mobility and Fatigue of Multiple Sclerosis (MS) Patients With Chronic Cerebrospinal Venous Insufficiency (CCSVI). Withdrawn NCT01555684
226 Does Minimal Post-operative Compression Affect the Outcome for Endovenous Ablation in Treating Varicose Vein Patients? Withdrawn NCT02241707
227 Efficacy of Vasculera in Prevention on Post-op Pain and Edema Following Lower Extremity Venous Treatment in the Outpatient Setting. Withdrawn NCT02936271
228 Treatment of Chronic Wound Staphylococcus Aureus Biofilms With Staphylococcus Epidermidis Esp Protein to Promote Healing Withdrawn NCT01646502
229 Head Circumference Growth in Children Who Develop Multiple Sclerosis Later in Life -- a Retrospective Analysis Withdrawn NCT01377805

Search NIH Clinical Center for Venous Insufficiency

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Cochrane evidence based reviews: venous insufficiency

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Genetic Tests for Venous Insufficiency

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Genetic tests related to Venous Insufficiency:

# Genetic test Affiliating Genes
1 Venous Insufficiency 29
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Anatomical Context for Venous Insufficiency

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MalaCards organs/tissues related to Venous Insufficiency:

41
Skin, Testes, Endothelial, Brain, Bone, Breast, Heart
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Publications for Venous Insufficiency

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Articles related to Venous Insufficiency:

(showing 4672, show less)
# Title Authors PMID Year
1
Tissue-engineered transcatheter vein valve. 38
31195302 2019
2
Vascular training does matter in the outcomes of saphenous high ligation and stripping. 38
31068278 2019
3
Efficacy of balloon venoplasty alone in the correction of nonthrombotic iliac vein lesions. 38
31176659 2019
4
Virchow's triad in "silent" deep vein thrombosis. 38
31078515 2019
5
Safety and efficacy of venous ablation in octogenarians. 38
31421837 2019
6
Overview of venous pathology related to repetitive vascular trauma in athletes. 38
31231058 2019
7
Mechanochemical ablation as an alternative to venous ulcer healing compared with thermal ablation. 38
31421838 2019
8
Endovenous cyanoacrylate glue to treat varicose veins and chronic venous insufficiency-Experience gained from our first 100+ truncal venous ablations in a multi-ethnic Asian population using the Medtronic VenaSeal™ Closure System. 38
30691376 2019
9
Ablation therapy with cyanoacrylate glue and laser for refluxing great saphenous veins - a prospective randomised study. 38
31014200 2019
10
Impact of Great Saphenous Vein Foam Sclerotherapy on Quality of Life and Photoplethysmography Findings in Chronic Venous Insufficiency: One-Year Follow-up. 38
31397782 2019
11
Histopathological changes to the vascular wall after treatment of great saphenous veins using n-butyl-2-cyanoacrylate. 38
31063085 2019
12
Survival and Comparison of External Bleeding Methods in Artery-Only Distal Finger Replantations. 38
31421938 2019
13
Association between venous reflux and diameter of great saphenous vein in lower thigh. 38
31402294 2019
14
Expression profile of tRNA‑derived fragments and their potential roles in human varicose veins. 38
31432124 2019
15
Scientific Papers and Patents on Substances with Unproven Effects. Part 2. 38
31424374 2019
16
The influence of May-Thurner syndrome on post-thrombotic syndrome in young women. 38
30848698 2019
17
One-Year Results of Iliocaval Stenting. 38
30826434 2019
18
Therapeutic potential of natural compounds in inflammation and chronic venous insufficiency. 38
31096120 2019
19
High tolerance of progressive elastic compression in peripheral arterial disease. 38
31159678 2019
20
Chronic venous insufficiency and venous microangiopathy: management with compression and Pycnogenol®. 38
31347820 2019
21
[Chronic leg ulcers in older patients]. 38
31187184 2019
22
Saphenous vein histopathology 5.5 years after cyanoacrylate closure. 38
31281102 2019
23
Defining the utility of anteroposterior venography in the diagnosis of venous iliofemoral obstruction. 38
30926244 2019
24
Is it necessary to dilate stents in management of nonthrombotic iliac vein lesions? 38
31203858 2019
25
Influences of sodium and glycosaminoglycans on skin oedema and the potential for ulceration: a finite-element approach. 38
31417698 2019
26
Distribution of psychogenic and vascular impotence in a tertiary health-care center's cohort: A retrospective study using penile Doppler imaging. 38
31272908 2019
27
Biobehavioral Mechanisms Associated With Nonhealing Wounds and Psychoneurologic Symptoms (Pain, Cognitive Dysfunction, Fatigue, Depression, and Anxiety) in Older Individuals With Chronic Venous Leg Ulcers. 38
31142148 2019
28
Examination of the effects of a new compression garment on skin tissue oxygenation in healthy volunteers. 38
31295092 2019
29
Severe phlebitis-like abnormal reaction following great saphenous vein cyanoacrylate closure. 38
31078516 2019
30
Complete blood count and penile colour doppler ultrasonography findings in erectile dysfunction: Is there a relationship? 38
31273827 2019
31
May-Thurner Syndrome: An often-missed cause of chronic pelvic pain. 38
30908405 2019
32
Relationships between the use of pharmacomechanical catheter-directed thrombolysis, sonographic findings, and clinical outcomes in patients with acute proximal DVT: Results from the ATTRACT Multicenter Randomized Trial. 38
31354089 2019
33
Medical compression stockings on the skin moisture in patients with chronic venous disease. 38
31364497 2019
34
Therapeutic compression materials and wound dressings for chronic venous insufficiency: A comprehensive review. 38
31339655 2019
35
A critical review on the three-dimensional finite element modelling of the compression therapy for chronic venous insufficiency. 38
31319767 2019
36
A near-infrared spectroscopy-assisted test discriminates patients with peripheral arterial disease and venous insufficiency with changes of foot oxygenation following light elastic compression therapy. 38
30838936 2019
37
Neoaorta Reconstruction Using Both Femoral Veins in a Patient with Secondary Aortoenteric Fistula. 38
31142428 2019
38
Impact of Venous Outflow Pattern on Flap Compromise in Head and Neck Reconstruction: Review of 309 Radial Forearm Free Flaps. 38
31166265 2019
39
Procedural training for the management of superficial venous insufficiency: A survey of Rouleaux Club members. 38
31238797 2019
40
MR venography using time-resolved imaging in interventional management of pelvic venous insufficiency. 38
30847564 2019
41
[Endovenous Treatment of Varicose Veins and Chronic Venous Insufficiency]. 38
31163465 2019
42
No association between variations in extracranial venous anatomy and clinical outcomes in multiple sclerosis patients over 5 years. 38
31185944 2019
43
Incidence and Risk Factors for Deep Vein Thrombosis after Radiofrequency and Laser Ablation of the Lower Extremity Veins. 38
31201974 2019
44
Are there differences in risk factors, microbial aspects, and prognosis of cellulitis between compensated and decompensated hepatitis C virus-related cirrhosis? 38
31177653 2019
45
Evaluation of the Isokinetic Calf Muscle Strength and the Range of Motion of Joint in C3 Chronic Venous Insufficiency. 38
31297359 2019
46
Ankle joint mobility as a predictor of treatment prognosis in patients with chronic venous insufficiency with venous ulcers. 38
31360156 2019
47
Escin suppresses HMGB1-induced overexpression of aquaporin-1 and increased permeability in endothelial cells. 38
30972964 2019
48
Radiation exposure during non-thrombotic iliac vein stenting. 38
31067208 2019
49
Protocol for a systematic review and meta-analysis of interventions for pathologic perforator veins in chronic venous disease. 38
31048426 2019
50
Preliminary report of a new type of braided vein stent in animals. 38
30227789 2019
51
Impact of copper compression stockings on venous insufficiency and lipodermatosclerosis: A randomised controlled trial. 38
30149775 2019
52
When Technology Exceeds its Application: The First Reported Reconstruction of the Iliocaval Confluence Using an Aortic Endograft. 38
31312566 2019
53
Hemodynamics of cerebral veins analyzed by 2d and 4d flow mri and ultrasound in healthy volunteers and patients with multiple sclerosis. 38
31102341 2019
54
Ultrasound-based topographic analysis of tributary vein connection with the saphenous vein during ambulatory conservative hemodynamic correction of chronic venous insufficiency. 38
30777672 2019
55
Prevalence, risk factors, and evaluation of iliocaval obstruction in advanced chronic venous insufficiency. 38
30765330 2019
56
Duplex ultrasound findings and clinical classification of lower extremity chronic venous insufficiency in a Thai population. 38
30477978 2019
57
Hydrogen peroxide and cutaneous biology: Translational applications, benefits, and risks. 38
31103570 2019
58
Percutaneous transluminal angioplasty for treatment of chronic cerebrospinal venous insufficiency (CCSVI) in people with multiple sclerosis. 38
31150100 2019
59
Superficial Femoral Venous Aneurysm in a Patient with Klippel-Trenaunay Syndrome: The Femoral Hernia Mimic. 38
30500630 2019
60
A Wearable Compression Device to Normalise Calf Muscle Pump Function in Chronic Venous Insufficiency for Each Postural Position. 38
31003934 2019
61
Contact Dermatitis in the Elderly: Predisposing Factors, Diagnosis, and Management. 38
31037642 2019
62
Healing Tough Wounds Using Topical Oxygen Therapy During Hemodialysis Sessions. 38
31199100 2019
63
Endovascular stenting for chronic femoro-iliac venous obstructive disease: Clinical efficacy and short-term outcomes. 38
31036535 2019
64
Treatment of Leg Veins for Restless Leg Syndrome: A Retrospective Review. 38
31192073 2019
65
A comparison between Caucasian and Asian superficial venous anatomy and reflux patterns - Implications for potential precision endovenous ablation therapy. 38
31032714 2019
66
Persistent disparities in breast cancer surgical outcomes among hispanic and African American patients. 38
30683449 2019
67
Transilluminated powered phlebectomy in the treatment of large area venous leg ulcers: A case-control study with 3 years follow-up. 38
30556350 2019
68
Carboxytherapy: Controls the inflammation and enhances the production of fibronectin on wound healing under venous insufficiency. 38
30467979 2019
69
Early complications of endovenous laser ablation. 38
30810002 2019
70
Comparison of Four Haemodynamic Tests that Quantify Superficial Venous Insufficiency. 38
30898493 2019
71
Therapeutic approach to chronic venous insufficiency - clinical benefits of red-vine-leaf-extract AS 195 (Antistax®). 38
30940301 2019
72
[New methods of interventional treatment of varicose veins]. 38
31099760 2019
73
Cardiovascular Disease: Chronic Venous Insufficiency and Varicose Veins. 38
30995000 2019
74
Incidence and distribution of lower extremity reflux in patients with pelvic venous insufficiency. 38
30943834 2019
75
Association Between Hemorrhoids and Lower Extremity Chronic Venous Insufficiency. 38
31249764 2019
76
Association between varicose veins anatomical pattern and procedural complications following endovascular laser photothermolysis for chronic venous insufficiency. 38
30970086 2019
77
Vascular Tests for Dermatologists. 38
30989581 2019
78
Paradigm shift in geriatric fracture treatment. 38
30725152 2019
79
LIMPRINT: Estimation of the Prevalence of Lymphoedema/Chronic Oedema in Acute Hospital in In-Patients. 38
30995191 2019
80
[Varicoceles, pelvic varices and pelvic congestion syndrome: Interventional radiology in diagnosis and treatment]. 38
31097262 2019
81
Erosive Pustular Dermatosis of the Leg Successfully Treated With an Oral Retinoid and a Bi-layered Skin Substitute 38
30909353 2019
82
Antibiogram in the biopsy of chronic venous ulcers related to sudden changes in the pain profile. 38
31131817 2019
83
Burden and Suffering in Chronic Venous Disease. 38
30758739 2019
84
Ultrasound-accelerated catheter-assisted thrombolytic therapy applicatıons in deep vein thrombosis. 38
30837430 2019
85
Evaluation of Antibiotic Treatment on the Duration of Hospitalization of Patients with Erysipelas and Bacterial Cellulitis. 38
30535927 2019
86
Effect of Horse-chestnut seed extract on matrix metalloproteinase-1 and -9 during diabetic wound healing. 38
31353546 2019
87
Current Therapeutic Interventions in Lower Extremity Venous Insufficiency: a Comprehensive Review. 38
30830460 2019
88
Regarding "Retrograde administration of ultrasound-guided endovenous microfoam chemical ablation for the treatment of superficial venous insufficiency". 38
30771837 2019
89
A pilot study of venous flow augmentation using a novel mechanical graded intermittent sequential compression device for venous insufficiency. 38
30612969 2019
90
"Waiting for Science to Catch up with Practice": an examination of 10-year YouTube trends in discussions of chronic cerebral spinal venous insufficiency treatment for multiple sclerosis. 38
30913949 2019
91
Venous leg symptoms in patients with varicocele: A multicenter assessment study (VEIN-TURKEY study). 38
29793400 2019
92
Effects of preventive use of compression stockings for elderly with chronic venous insufficiency and swollen legs: a systematic review and meta-analysis. 38