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MCID: VNS003
MIFTS: 55

Venous Insufficiency

Categories: Blood diseases, Cardiovascular diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Venous Insufficiency

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MalaCards integrated aliases for Venous Insufficiency:

Name: Venous Insufficiency 12 29 44 15 71 32
Peripheral Venous Insufficiency 12

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:10128
ICD9CM 34 459.81
MeSH 44 D014689
NCIt 50 C127822
SNOMED-CT 67 20696009
ICD10 32 I87.2
UMLS 71 C0042485
Sources

Summaries for Venous Insufficiency

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Disease Ontology : 12 A vein disease that is characterized by impaired flow of blood through the veins.

MalaCards based summary : Venous Insufficiency, also known as peripheral venous insufficiency, is related to lipodermatosclerosis and post-thrombotic syndrome. An important gene associated with Venous Insufficiency is F2 (Coagulation Factor II, Thrombin), and among its related pathways/superpathways are Innate Immune System and Integrin Pathway. The drugs Hesperidin and Racepinephrine have been mentioned in the context of this disorder. Affiliated tissues include skin, endothelial and brain, and related phenotypes are cardiovascular system and homeostasis/metabolism

Sources

Related Diseases for Venous Insufficiency

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Diseases in the Venous Insufficiency family:

Chronic Venous Insufficiency

Diseases related to Venous Insufficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 523)
# Related Disease Score Top Affiliating Genes
1 lipodermatosclerosis 31.9 VEGFA PLAT MMP1
2 post-thrombotic syndrome 31.0 VCAM1 SERPINE1 ICAM1 F5 F2
3 telangiectasis 30.7 VEGFA NDP ELN
4 relapsing-remitting multiple sclerosis 30.2 TIMP1 MMP9 ITGA4 ICAM1
5 hemorrhoid 30.1 MMP9 F2 CRP
6 chronic venous insufficiency 30.0 VEGFA VCAM1 TIMP1 SERPINE1 SELP SELL
7 chronic ulcer of skin 29.9 VEGFA MMP9 MMP1 CRP
8 papilledema 29.9 VEGFA F2 CRP
9 infective endocarditis 29.9 SERPINE1 F2 CRP
10 exanthem 29.8 VEGFA F2 CRP
11 retinal vascular disease 29.8 VEGFA NDP MTHFR ICAM1
12 purpura 29.8 VWF F2 CRP
13 portal hypertension 29.8 VWF VEGFA F2 ELN
14 sickle cell disease 29.7 VWF VCAM1 SELP SELL
15 arteriosclerosis obliterans 29.7 VCAM1 SELP ICAM1
16 thrombophlebitis 29.7 VWF SERPINE1 PLAT MTHFR F5 F2
17 arachnoiditis 29.7 IL1A CRP
18 microvascular complications of diabetes 5 29.6 VEGFA VCAM1 SERPINE1 ICAM1
19 thrombophilia due to thrombin defect 29.6 VWF SERPINE1 PLAT MTHFR F5 F2
20 intracranial hypertension 29.6 SERPINE1 MTHFR F5 F2
21 brain edema 29.6 VEGFA MMP9 CRP
22 sleep apnea 29.6 VEGFA VCAM1 SERPINE1 ICAM1 CRP
23 contact dermatitis 29.5 VCAM1 SELL IL1A ICAM1
24 sudden sensorineural hearing loss 29.5 MTHFR F5 F2
25 arteries, anomalies of 29.5 VEGFA VCAM1 SERPINE1 ICAM1 CRP
26 hemangioma 29.5 VWF VEGFA MMP9 F2
27 buerger disease 29.5 VEGFA VCAM1 ICAM1 CRP
28 atrial fibrillation 29.4 VWF SELP PLAT F2 CRP
29 peripheral artery disease 29.3 VWF VEGFA VCAM1 SELP ICAM1 CRP
30 thrombosis 29.3 VWF SERPINE1 SELP PLAU PLAT MTHFR
31 tetralogy of fallot 29.3 VEGFA MTHFR MMP9 ELN CRP
32 skin disease 29.2 SELL MMP1 IL1A ICAM1 ELN CRP
33 retinal vein occlusion 29.2 VEGFA SERPINE1 MTHFR F5 F2
34 intermittent claudication 29.2 VWF VEGFA SERPINE1 SELP F2 CRP
35 amaurosis fugax 29.2 SERPINE1 MTHFR MMP9 F5
36 primary progressive multiple sclerosis 29.2 VCAM1 TIMP1 SELL MMP9 ITGA4 ICAM1
37 pulmonary embolism 29.2 VWF SERPINE1 PLAU PLAT MTHFR F5
38 vasculitis 29.2 VWF VCAM1 SELP SELL ITGA4 ICAM1
39 thrombophilia 29.1 VWF SERPINE1 SELP PLAT MTHFR F5
40 varicose veins 29.1 VWF VEGFA TIMP1 PLAT MTHFR MMP9
41 osteoarthritis 29.1 TIMP1 MMP9 MMP1 IL1A CRP
42 pulmonary disease, chronic obstructive 29.0 TIMP1 MMP9 MMP1 ELN CRP
43 endocarditis 29.0 VCAM1 SERPINE1 PLAT IL1A F2 CRP
44 central retinal vein occlusion 28.9 VWF VEGFA PLAT MTHFR F5 F2
45 hydronephrosis 28.7 VWF VEGFA TIMP1 SELL MMP9 ICAM1
46 homocysteinemia 28.6 VWF VCAM1 SERPINE1 MTHFR F5 F2
47 proteasome-associated autoinflammatory syndrome 1 28.6 VCAM1 SELP SELL MMP9 IL1A ICAM1
48 vein disease 28.5 VWF VEGFA SERPINE1 SELP PLAT MTHFR
49 chronic kidney disease 28.5 VEGFA VCAM1 SERPINE1 MTHFR MMP9 ICAM1
50 arteriosclerosis 28.4 VCAM1 TIMP1 SERPINE1 SELP MMP9 ICAM1

Comorbidity relations with Venous Insufficiency via Phenotypic Disease Network (PDN): (show all 20)


Acute Cystitis Aortic Valve Disease 1
Bronchitis Chronic Pulmonary Heart Disease
Decubitus Ulcer Deficiency Anemia
Familial Atrial Fibrillation Femoral Vein Thrombophlebitis
Generalized Atherosclerosis Heart Disease
Hypertension, Essential Hypothyroidism
Iron Deficiency Anemia Mitral Valve Disease
Osteoporosis Peripheral Vascular Disease
Post-Thrombotic Syndrome Protein-Energy Malnutrition
Schizophreniform Disorder Tinea Pedis

Graphical network of the top 20 diseases related to Venous Insufficiency:



Diseases related to Venous Insufficiency
Sources

Symptoms & Phenotypes for Venous Insufficiency

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MGI Mouse Phenotypes related to Venous Insufficiency:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.42 CRP F2 F5 ICAM1 IL1A ITGA4
2 homeostasis/metabolism MP:0005376 10.36 CRP F2 F5 ICAM1 IL1A MMP1
3 immune system MP:0005387 10.31 CRP F2 ICAM1 IL1A ITGA4 MMP1
4 growth/size/body region MP:0005378 10.29 F2 F5 ICAM1 MMP9 MTHFR PLAT
5 hematopoietic system MP:0005397 10.27 ICAM1 IL1A ITGA4 MMP9 PLAT PLAU
6 mortality/aging MP:0010768 10.2 F2 F5 ICAM1 ITGA4 MMP9 MTHFR
7 integument MP:0010771 10.15 F2 F5 ICAM1 IL1A MMP9 MTHFR
8 neoplasm MP:0002006 9.91 ICAM1 IL1A MMP1 MMP9 PLAU SELL
9 reproductive system MP:0005389 9.85 F2 MMP9 MTHFR NDP PLAT PLAU
10 respiratory system MP:0005388 9.61 F2 MMP9 PLAT PLAU SELL SELP
11 skeleton MP:0005390 9.32 F2 MMP9 MTHFR NDP PLAT PLAU
Sources

Drugs & Therapeutics for Venous Insufficiency

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Drugs for Venous Insufficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 75)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hesperidin Approved, Investigational Phase 4 520-26-3 53477767
2
Racepinephrine Approved Phase 4 329-65-7 838
3
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
4
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
5
Troxerutin Investigational Phase 4 7085-55-4 5486699
6
Coumarin Experimental Phase 4 91-64-5 323
7 Anticoagulants Phase 4
8 Anti-Inflammatory Agents Phase 4
9 Salicylates Phase 4
10 Heparinoids Phase 4
11 Hemostatics Phase 4
12 Aminaftone Phase 4
13 Coagulants Phase 4
14 Anesthetics, Local Phase 4
15 Adrenergic alpha-Agonists Phase 4
16 Respiratory System Agents Phase 4
17 Anti-Asthmatic Agents Phase 4
18 Sodium Channel Blockers Phase 4
19 Adrenergic beta-Agonists Phase 4
20 Epinephryl borate Phase 4
21 Adrenergic Agents Phase 4
22 Mydriatics Phase 4
23 Diuretics, Potassium Sparing Phase 4
24 Sympathomimetics Phase 4
25 Neurotransmitter Agents Phase 4
26 Vasoconstrictor Agents Phase 4
27 Bronchodilator Agents Phase 4
28 Adrenergic Agonists Phase 4
29 Anti-Arrhythmia Agents Phase 4
30
Polidocanol Approved Phase 3 9002-92-0
31
carbamide peroxide Approved Phase 2, Phase 3 124-43-6
32
Thrombin Approved, Investigational Phase 3
33 Tin Fluorides Phase 3
34 Grape Approved Phase 2
35
Methyl salicylate Approved, Vet_approved Phase 2 119-36-8 4133
36
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 2 65-23-6 1054
37
Quercetin Experimental, Investigational Phase 2 117-39-5 5280343
38
Horse chestnut Experimental Phase 2
39 Protective Agents Phase 2
40 Antioxidants Phase 2
41 Vitamin B 6 Phase 2
42 Vitamin B Complex Phase 2
43 Antirheumatic Agents Phase 2
44
Pyridoxal Experimental, Nutraceutical Phase 2 66-72-8 1050
45
Silicon Approved, Investigational 7440-21-3 4082203
46
Copper Approved, Investigational 7440-50-8 27099
47
Pentoxifylline Approved, Investigational 6493-05-6 4740
48
Aspirin Approved, Vet_approved 50-78-2 2244
49
Ticlopidine Approved 55142-85-3 5472
50
Chlorhexidine Approved, Vet_approved 55-56-1 9552079 2713

Interventional clinical trials:

(show top 50) (show all 170)
# Name Status NCT ID Phase Drugs
1 The Effect of Neuromuscular Electrical Therapy on Pain in Patients With Venous Ulcers: a Controlled Clinical Trial Completed NCT01372020 Phase 4
2 Gliding Aids for Medical Compression Stockings - Practicability in Elderly Patients With Chronic Venous Insufficiency Completed NCT01432795 Phase 4
3 Clinical Non-inferiority Study Between Diosmin 600 mg Tablets and Diosmin 900 mg + Hesperidin 100 mg Tablets in Symptomatic Chronic Venous Insufficiency After 6 Months of Treatment: Single-blind, Randomized, Parallel Group Study Completed NCT03471910 Phase 4 Diosmin;Diosmin / Hesperidin
4 Evaluation of Efficacy and Safety of the Fixed-dose Combination of Coumarin and Troxerutin (Venalot®) Versus Placebo in the Symptomatic Treatment of Chronic Venous Insufficiency - VENACT Completed NCT01848210 Phase 4 Coumarin/troxerutin;Placebo
5 A 6-week, Open, Multicentre Safety Trial to Evaluate the Tolerability Profile of Antistax® Film Coated Tablets (Extr. Vitis Viniferae Siccum), 360 mg/Day Per os, in Male and Female Patients Suffering From Chronic Venous Insufficiency Completed NCT02184234 Phase 4 Antistax film coated tablets
6 The Fate Of Calf Perforators After Endovenous Laser Ablation Of Saphenous Veins Completed NCT01458795 Phase 4
7 SocknLeg - a User Friendly Medical Compression Study of a Modified Application of a Medical Device Completed NCT02621632 Phase 4
8 Radiofrequency Ablation vs Laser Ablation of the Incompetent Greater Saphenous Vein: A Prospective Randomized Trial Completed NCT02236338 Phase 4
9 Study of Antiinflammatory Effects of Detralex (Daflon) in Patients With Chronic Venous Disease Completed NCT01654016 Phase 4 Detralex
10 Evaluate the Efficacy and Safety of Esarin Gel in the Treatment of Chronic Venous Insufficiency or Varicose Vein Combine With Superficial Vein Thrombophlebitis in Outpatient Completed NCT02346058 Phase 4 Esarin Gel
11 Multicenter, Prospective, Randomized, Double-Blind Study to Assess the Therapeutic Efficacy and Safety of the Use of Venocur Triplex® in Patients With Chronic Venous Insufficiency Completed NCT00835822 Phase 4 Venocur Triplex®;placebo
12 Randomized Double-blind Trial Between Clinical and Endovascular Treatment in Patients With Advanced Chronic Venous Insufficiency and Iliac Venous Obstruction Completed NCT02149212 Phase 4 Phlebotonic
13 A Randomised Clinical Trial Comparing Endovenous Laser Ablation and Mechanochemical Ablation (ClariVein®) in the Management of Superficial Venous Insufficiency Active, not recruiting NCT02627846 Phase 4 Lidocaine with 1:200,000 epinephrine solution;Lidocaine with 1:200,000 epinephrine solution;Sodium Bicarbonate;Sodium Tetradecyl Sulphate
14 Radiofrequency Ablation vs. Laser Ablation of the Incompetent Small Saphenous Vein: A Prospective Randomized Trial Terminated NCT02248740 Phase 4
15 A Randomised Clinical Trial Comparing Standard Cannula Delivered Foam Sclerotherapy, Catheter Directed Foam Sclerotherapy and ClariVein® Mechanochemical Ablation in the Management of Superficial Venous Insufficiency. Withdrawn NCT02010437 Phase 4 Sodium Tetradecyl Sulphate (STS)
16 Comparative Efficacy of Two Preparations of the Association Diosmin (450 mg) + Hesperidin (50 mg) in the Treatment of Chronic Venous Insufficiency (CVI) Unknown status NCT01110512 Phase 3 Flavonid;Daflon
17 Study Clinical, Multicenter,Phase III,Prospective,Randomized,Comparative Double Blind/Double-dummy to Assess the Efficacy and Tolerability of the Use of Varicell in Reducing the Symptoms Caused by Chronic Venous Insufficiency and Hemorrhoidal Syndrome When Compared With Daflon Unknown status NCT01321619 Phase 3 Daflon;Varicell placebo
18 A Clinical Multicenter, Phase III, Prospective, Randomized, Double-blind, Comparative Study to Evaluate the Efficacy and Tolerability of Venaflon Use in Reducing the Symptoms Caused by Chronic Venous Insufficiency When Compared With Daflon Unknown status NCT01477281 Phase 3 Daflon;Venaflon (Diosmin and Hesperidin)
19 A Comparative Study to Assess the Efficacy and Safety of Endolex Forte vs Diosmin and Hesperidin in Reducing the symptomatoLogy of Patients With ChronIc VeNous Insufficiency Between Functional Classes CEAP 1-4, During a Period of 6 Months Unknown status NCT02927483 Phase 3
20 A Prospective, Multi-Centre, Double Blind, Randomized, Placebo Controlled Trial to Evaluate the Safety and Efficacy of ICXP007 in a Phase III Trial With Four-Layer Therapeutic Compression, for the Treatment of Non-Infected Skin Leg Ulcers, Due to Venous-Insufficiency Unknown status NCT00232973 Phase 3 ICXP007
21 A Phase 3 Randomized, Double Blind, Vehicle Controlled Study Investigating the Safety and Efficacy of HP802-247 in the Treatment of Venous Leg Ulcers >12 cm2 to ≤ 36 cm2 Completed NCT01737762 Phase 3
22 Efficacy on Volume Reduction and Tolerance of Progressiv' Medical Compressive Therapy (MCT) V0322 BC in Patients With Chronic Venous Oedema. International, Multicentric, Randomised, Controlled, Double Blind Study, in Two Parallel Groups v0322 bc Versus Placebo Completed NCT01402921 Phase 3
23 Treatment of Greater Saphenous Vein (GSV) Insufficiency Using Echo-Guided Sclerotherapy With Lauromacrogol 400 Foam -Comparative Study of 3% Versus 1% Concentration. Completed NCT00348764 Phase 3 lauromacrogol
24 A 12-week, Double-blind, Randomised, Placebo-controlled, Multicentre Trial to Evaluate Efficacy and Tolerability of Antistax Film-coated Tablets, 360 mg/Day Orally, in Male and Female Patients Suffering From Chronic Venous Insufficiency. Completed NCT00292435 Phase 3 Read vine leaf extract (AS 195)
25 Prospective, Randomized and Explorative Controlled Study About Influences of Compression Stockings on Skin's Barrier Function at Patients With Chronic Venous Insufficiency Completed NCT00196443 Phase 2, Phase 3
26 A 12-week, Double-blind, Randomised, Placebo-controlled, Multicentre Trial to Evaluate Efficacy and Tolerability of Antistax® Film Coated Tablets, 720 mg/Day Orally, in Male and Female Patients Suffering From Chronic Venous Insufficiency Completed NCT00855179 Phase 3 Red vine leaf extract (AS 195);Placebo
27 Clinical Study of BNS003 on Swelling Due to Disorder of Leg Venous Reflux Completed NCT02211898 Phase 3 BNS003
28 Evaluation of the Efficacy of Spa Treatment for Prevention of Leg Ulcers in Advanced Chronic Venous Insufficiency. Completed NCT00838500 Phase 3 Immediate spa treatment;Late spa treatment
29 A 12-week, Double-blind, Randomised, Placebo-controlled, Multicentre Trial to Evaluate Efficacy and Tolerability of Antistax® Film Coated Tablets, 360 mg/Day Orally, in Male and Female Patients Suffering From Chronic Venous Insufficiency Completed NCT02191254 Phase 3 Antistax®;Placebo
30 Crenobalneotherapy in the Treatment of Chronic Venous Insufficiency. A Randomized Clinical Trial. Completed NCT01956318 Phase 3
31 A Phase 3 Randomized Safety and Efficacy Trial of HP802-247 in the Treatment of Chronic Venous Leg Ulcers (EU) Terminated NCT01853384 Phase 3
32 Clinical Evaluation of the Safety and Effectiveness of Topical Autologous Platelet Gel (APG) for the Treatment of Lower Extremity Chronic Venous Insufficiency Ulcers. A Multicenter, Randomized, Controlled Clinical Trial Withdrawn NCT00273234 Phase 3
33 Endovenous Treatment of the Saphenous Vein With Biolitec 1470nm Laser Versus Vnus Closure Fast Unknown status NCT01972633 Phase 1, Phase 2
34 An Open-label, Non-randomized, Phase I/II Study of Allogeneic Human Umbilical Cord Tissue-Derived Mesenchymal Stem Cells (UC-MSC) and Liberation Therapy (When Associated With Chronic Cerebrovascular Venous Insufficiency) in Patients With Relapsing Remitting Multiple Sclerosis (RRMS) Unknown status NCT02587715 Phase 1, Phase 2
35 Endovascular Correction of Chronic Cerebrospinal Venous Insufficiency (CCSVI) and Evaluation of Influence of These Treatments on the Symptoms of Multiple Sclerosis Completed NCT01264848 Phase 1, Phase 2
36 A Randomized, Double-Blind, Placebo-Controlled, Dose-Response Study of the Safety and Efficacy of Thymosin Beta 4 in the Treatment of Patients With Venous Stasis Ulcers Completed NCT00832091 Phase 2 Thymosin Beta 4;Placebo
37 Assessment of Lymphatic Structure and Function Pre- and Post- Treatment and During Recovery in Head and Neck Cancer Patients Using NIR Fluorescence Lymphatic Imaging Completed NCT02946021 Phase 1, Phase 2 NIRFLI with ICG
38 Evaluation of DermStream(tm) - an Irrigation Product for Chronic Wound Management Completed NCT00310752 Phase 1, Phase 2
39 Physical Conditioning in Management of Chronic Venous Insufficiency Completed NCT00013273 Phase 2
40 A Phase II Randomized Study to Evaluate the Safety of the Compression Test Device Using Intermittent Pneumatic Compression Mode in Subjects With Venous Insufficiency and Oedema Completed NCT00732823 Phase 2
41 A 17 Week, Randomised, Double-blind, Placebo Controlled Cross-over Trial to Evaluate the Efficacy of Antistax® Film Coated Tablets (Extr. Vitis Vinifera Siccum), 360 mg/Day p.o. in Improving Microcirculation of the Skin in the Leg of Male and Female Patients Suffering From Chronic Venous Insufficiency Completed NCT02191163 Phase 2 Antistax®;Placebo
42 The Ability of Antistax® to Improve Chronic Venous Insufficiency (CVI) I and II in Male and Female Patients: a Dose Response Study Completed NCT02191280 Phase 2 Antistax®, low dose;Antistax®, high dose;Placebo
43 The Efficacy of Red Vine Leaf Extract, Butcher's Broom, Horse Chestnut and Vitamin B6 on the Quality of Life in Females With Chronic Venous Insufficiency Completed NCT02498327 Phase 2
44 The Efficacy of Red Vine Leaf Extract, Butcher's Broom, Horse Chestnut and Vitamin B6 in the Treatment of Symptoms Associated With Chronic Venous Insufficiency Completed NCT02483962 Phase 2
45 Phase I/II Interventional Clinical Trial of Balloon Venoplasty for Chronic Cerebrospinal Venous Insufficiency in Multiple Sclerosis Patients Completed NCT01864941 Phase 1, Phase 2
46 Monitoring and Managing Newly Healed Chronic Leg and Foot Ulcer Skin Temperature: A Cooling Intervention (MUSTCOOL) to Prevent Ulcer Recurrence Completed NCT02626156 Phase 2
47 Preventing Venous Leg Ulcers With Cryotherapy: A Randomized Clinical Trial Completed NCT01509599 Phase 1, Phase 2
48 A Phase 2, Randomized, Double-Blind, Vehicle-Controlled, Proof-of-Concept Study to Evaluate the Efficacy, Safety, and Local Tolerability of Crisaborole Ointment, 2%, in Adult Participants With Stasis Dermatitis Without Active Skin Ulceration Recruiting NCT04091087 Phase 2 crisaborole ointment
49 A Prospective, Randomized, Controlled, Multi-Center, Double Blind Study of ClariVein RES for Treatment of Venous Insufficiency Associated With Incompetent Saphenous Veins Due to Superficial Venous Reflux Recruiting NCT03311269 Phase 2 Sodium Tetradecyl Sulfate 1% Injection;Sodium Tetradecyl Sulfate 3% Injection
50 Efficacy of TR 987, Beta-1,3-1,6-D-glucan, in the Treatment of Chronic Venous Insufficiency Ulcers: a Two-arm, Double-blind, Placebo-controlled, Randomized Controlled Trial. Active, not recruiting NCT03154619 Phase 2 0.1% TR 987;Placebo gel

Search NIH Clinical Center for Venous Insufficiency

Inferred drug relations via UMLS 71 / NDF-RT 51 :


Gotu Kola Extract
GOTU KOLA LIQUID

Cochrane evidence based reviews: venous insufficiency

Sources

Genetic Tests for Venous Insufficiency

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Genetic tests related to Venous Insufficiency:

# Genetic test Affiliating Genes
1 Venous Insufficiency 29
Sources

Anatomical Context for Venous Insufficiency

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MalaCards organs/tissues related to Venous Insufficiency:

40
Skin, Endothelial, Brain, Breast, Heart, Colon, Neutrophil
Sources

Publications for Venous Insufficiency

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Articles related to Venous Insufficiency:

(show top 50) (show all 4921)
# Title Authors PMID Year
1
Mechanochemical ablation for great and small saphenous veins insufficiency in patients with type III shunt. 61
32847473 2021
2
Validation of a Swedish version of a short patient-reported outcome measure for superficial venous insufficiency. 61
32736096 2021
3
Presentation patterns in women with pelvic venous disorders differ based on age of presentation. 61
32869695 2021
4
In Reference to Chronic Cerebrospinal Venous Insufficiency and Meniere's Disease: Interventional Versus Medical Therapy. 61
32374415 2021
5
In Response to Chronic Cerebrospinal Venous Insufficiency and Meniere's Disease: Interventional Versus Medical Therapy. 61
32579708 2021
6
Regarding Chronic Cerebrospinal Venous Insufficiency and Meniere's Disease: Interventional Versus Medical Therapy. 61
32579709 2021
7
Clinical outcome of short-term compression after sclerotherapy for telangiectatic varicose veins. 61
32502730 2021
8
Early results of an Asian prospective multicenter VenaSeal real-world postmarket evaluation to investigate the efficacy and safety of cyanoacrylate endovenous ablation for varicose veins. 61
32387378 2021
9
Association between vein diameters, reflux characteristics, and clinical severity in patients with chronic venous insufficiency in Northwest China. 61
32730997 2021
10
Effect of Pre-Procedure Clopidogrel With Iliac Vein Stenting in Non-Thrombotic Vein Lesions. 61
33602039 2021
11
Efficacy of Human Recombinant Epidermal Growth Factors vs Conventional Therapy for the Treatment of Chronic Venous Ulcers: A Retrospective Case Series. 61
33591927 2021
12
Predictors for readmission due to cellulitis among Japanese patients. 61
33523517 2021
13
Transabdominal duplex ultrasound and intravascular ultrasound planimetry measures of common iliac vein stenosis are significantly correlated in a symptomatic population. 61
33548556 2021
14
Comparative efficacy and life quality effects of surgical stripping, radiofrequency ablation, and cyanoacrylate embolization in patients undergoing treatment for great saphenous vein insufficiency. 61
32741257 2021
15
Internal valvuloplasty combined with sleeve wrapping in the treatment of severe deep venous incompetence: A case report. 61
33530885 2021
16
Two-Year Follow-Up after Endovenous Closure with Short-Chain Cyanoacrylate versus Laser Ablation in Venous Insufficiency. 61
33562190 2021
17
A New Method Involving Percutaneous Application in the Treatment of Deep Venous Insufficiency: An Experimental Study With Internal Compression Therapy in a Porcine Model. 61
33078694 2021
18
Imaging findings of pelvic venous insufficiency in patients with postural orthostatic tachycardia syndrome. 61
32757696 2021
19
Association between lower extremity venous insufficiency and duration of atrial fibrillation. 61
33601963 2021
20
Performance of two clinical scales to assess quality of life in post-thrombotic syndrome. 61
33548557 2021
21
Endovenous radiofrequency for chronic superficial venous insufficiency: Clinical outcomes and impact in quality of life. 61
33546819 2021
22
Hemodynamic and Radiological Classification of Ovarian Veins System Insufficiency. 61
33567554 2021
23
Prevalence and characteristics of older people with pressure ulcers and legs ulcers, in nursing homes in Barcelona. 61
33485786 2021
24
Pelvic Congestion Syndrome. 61
33541587 2021
25
Clinical and Hemodynamic Outcome of Morbidly Obese Patients with Severe Chronic Venous Insufficiency with and without Bariatric Surgery: A Comparative Study. 61
33540136 2021
26
[Long-term healing of a therapy-refractory venous leg ulcer after crural fasciectomy and split skin graft transplantation]. 61
32720166 2021
27
Utility of Unilateral versus Bilateral Venous Reflux Studies for Venous Insufficiency. 61
33529718 2021
28
Safety and feasibility report on nonimplantable endovenous valve formation for the treatment of deep vein reflux. 61
33359385 2021
29
Comparison of unilateral vs bilateral and staged bilateral vs concurrent bilateral truncal endovenous ablation in the Vascular Quality Initiative. 61
32470615 2021
30
Treatment of superficial venous reflux in CEAP 6 patients: a comparison of cyanoacrylate glue and radiofrequency ablation techniques. 61
33453440 2021
31
Complete Venous Ulceration Healing after Perforator Ablation Does Not Depend on Treatment Modality. 61
32603845 2021
32
Examining risk factors and preventive treatments for first venous leg ulceration: A cohort study. 61
31884088 2021
33
Surgical management of post-thrombotic syndrome in chronic venous thoracic outlet syndrome. 61
33429091 2021
34
Sex differences in hospitalized adult patients with cellulitis: A prospective, multicenter study. 61
33508477 2021
35
The use of high-frequency skin ultrasound in the diagnosis of lipodermatosclerosis. 61
33500796 2021
36
A Modiied 3-Way Tap to Enhance the Stability and Uniformity of Sclerosant Foam. 61
32889163 2021
37
Protective effects of luteolin on the venous endothelium. 61
33469821 2021
38
The Analysis of Selected Morphological and Hemodynamic Parameters of the Venous System and Their Presumable Impact on the Risk of Recurrence after Varicose Vein Treatment. 61
33503977 2021
39
[One-year results of conservative and endovascular treatment of deep venous thrombosis followed by severe acute venous insufficiency]. 61
33570357 2021
40
Pre-operative predictors of lower extremity swelling following total knee arthroplasty in patients with venous insufficiency and osteoarthritis. 61
33409562 2021
41
The efficiency of exercise training in patients with venous insufficiency: A double blinded, randomized controlled trial. 61
33423620 2021
42
Risk factors of recurrent erysipelas in adult Chinese patients: a prospective cohort study. 61
33413190 2021
43
A randomized controlled noninferiority trial comparing radiofrequency with stripping and conservative hemodynamic cure for venous insufficiency technique for insufficiency of the great saphenous vein. 61
32353592 2021
44
Non-Invasive Capillary Blood Pressure Measurement Enabling Early Detection and Classification of Venous Congestion. 61
33513121 2021
45
Recurrence types 3 years after endovenous thermal ablation in insufficient saphenofemoral junctions. 61
32361003 2021
46
Trends of hospital-based surgery for varicose veins in the elderly. 61
32360785 2021
47
Randomized clinical trial of radiofrequency-induced thermotherapy combined with transilluminated powered phlebectomy versus high ligation and stripping for the treatment of lower limb varicose veins. 61
32454239 2021
48
Femoral vein wall thickness measurement: A new diagnostic tool for Behçet's disease. 61
32756998 2021
49
Lamiaceae in the treatment of cardiovascular diseases. 61
33049685 2021
50
Allergic Contact Dermatitis to VenaSeal After Chronic Venous Insufficiency Treatment Mimics Phlebitis. 61
33443376 2021
Sources

Variations for Venous Insufficiency

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Expression for Venous Insufficiency

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Search GEO for disease gene expression data for Venous Insufficiency.
Sources

Pathways for Venous Insufficiency

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Pathways related to Venous Insufficiency according to GeneCards Suite gene sharing:

(show all 40)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 14.01 VWF VEGFA VCAM1 TIMP1 SELL PLAU
2
Integrin Pathway 63
Show member pathways
 13.38 VEGFA VCAM1 SERPINE1 PLAU MMP9 MMP1
3
Cytokine Signaling in Immune system 65
Show member pathways
 13.34 VWF VEGFA VCAM1 TIMP1 MMP9 MMP1
4
Response to elevated platelet cytosolic Ca2+ 65
Show member pathways
 13.01 VWF VEGFA TIMP1 SERPINE1 SELP SELL
5
Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways 64
Show member pathways
 12.65 VEGFA VCAM1 MMP9 ITGA4 ICAM1
6
Degradation of the extracellular matrix 65
Show member pathways
 12.62 VCAM1 TIMP1 SERPINE1 MMP9 MMP1 ITGA4
7
Development VEGF signaling via VEGFR2 - generic cascades 23
Show member pathways
 12.37 VEGFA VCAM1 PLAU ICAM1
8
Folate Metabolism 1
Show member pathways
 12.3 SERPINE1 PLAT MTHFR ICAM1 F2 CRP
9
G-protein signaling Ras family GTPases in kinase cascades (scheme) 23
Show member pathways
 12.29 VEGFA TIMP1 SERPINE1 MMP1
10
Cell surface interactions at the vascular wall 65
Show member pathways
 12.24 SELP SELL MMP1 ITGA4 F2
11
ECM-receptor interaction 36
Show member pathways
 12.14 VWF VCAM1 ITGA4 ICAM1
12
Formation of Fibrin Clot (Clotting Cascade) 65
Show member pathways
 12.14 VWF SERPINE1 PLAU PLAT F5 F2
13
Cell adhesion molecules 36
12.13 VCAM1 SELP SELL ITGA4 ICAM1
14
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 65
12.07 VCAM1 SELL ITGA4 ICAM1
15
Complement and coagulation cascades 36 1
12.07 VWF SERPINE1 PLAU PLAT F5 F2
16
Adhesion 4
12.04 VCAM1 SERPINE1 MMP9 ITGA4 ICAM1
17
Fluid shear stress and atherosclerosis 36
12.02 VEGFA VCAM1 PLAT MMP9 IL1A ICAM1
18
Spinal Cord Injury 1
12 SELP MMP9 IL1A ICAM1
19
Senescence and Autophagy in Cancer 1
11.94 SERPINE1 PLAU PLAT IL1A
20
AGE-RAGE signaling pathway in diabetic complications 36
11.91 VEGFA VCAM1 SERPINE1 IL1A ICAM1
21
Rheumatoid arthritis 36
11.87 VEGFA MMP1 IL1A ICAM1
22
Angiogenesis (CST) 4
11.81 VWF TIMP1 MMP9
23
Bladder cancer 36 1
11.72 VEGFA MMP9 MMP1
24
Endochondral Ossification 1
11.7 VEGFA PLAU PLAT MMP9
25
Lung fibrosis 1
11.68 TIMP1 PLAU MMP9 ELN
26
IgA-Producing B Cells in the Intestine 64
11.67 VCAM1 ITGA4 ICAM1
27
Malaria 36
11.54 VCAM1 SELP ICAM1
28
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.53 VEGFA VCAM1 MMP9 MMP1 IL1A ICAM1
29
Interleukin-10 signaling 65
11.52 TIMP1 IL1A ICAM1
30
Cell adhesion_Plasmin signaling 23
11.52 VEGFA PLAU PLAT
31
Immune response_Role of integrins in NK cells cytotoxicity 23
11.47 VCAM1 ITGA4 ICAM1
32
Cell adhesion_Cell-matrix glycoconjugates 23
11.42 SELL MMP9 MMP1 ELN
33
amb2 Integrin signaling 1
11.4 SELP PLAU PLAT MMP9 ICAM1
34
Validated transcriptional targets of AP1 family members Fra1 and Fra2 1
11.34 PLAU MMP9 MMP1
35
Development_Leptin signaling via JAK/STAT and MAPK cascades 23
Show member pathways
 11.27 VEGFA TIMP1 CRP
36
Cell adhesion_ECM remodeling 23
11.22 TIMP1 SERPINE1 PLAU PLAT MMP9 MMP1
37
Interleukin-4 and 13 signaling 65
11.22 VEGFA VCAM1 TIMP1 MMP9 MMP1 IL1A
38
IL1 and megakaryocytes in obesity 1
11.18 TIMP1 MMP9 ICAM1 F2
39
Immune response_Oncostatin M signaling via JAK-Stat in human cells 23
11.05 VEGFA TIMP1 MMP1
40
Dissolution of Fibrin Clot 65
10.86 SERPINE1 PLAU PLAT
Sources

GO Terms for Venous Insufficiency

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Cellular components related to Venous Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 10.1 VWF VCAM1 TIMP1 SERPINE1 PLAU PLAT
2 cell surface GO:0009986 9.91 VEGFA VCAM1 PLAU PLAT NDP ITGA4
3 extracellular matrix GO:0031012 9.8 VWF VEGFA TIMP1 NDP MMP9 MMP1
4 extracellular region GO:0005576 9.8 VWF VEGFA TIMP1 SERPINE1 PLAU PLAT
5 collagen-containing extracellular matrix GO:0062023 9.76 VWF SERPINE1 PLAT NDP MMP9 ICAM1
6 platelet alpha granule lumen GO:0031093 9.72 VWF VEGFA TIMP1 SERPINE1 F5
7 extracellular space GO:0005615 9.5 VWF VEGFA VCAM1 TIMP1 SERPINE1 SELP

Biological processes related to Venous Insufficiency according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 10.05 VWF VCAM1 SELP SELL ITGA4 ICAM1
2 cellular protein metabolic process GO:0044267 9.91 TIMP1 MMP1 F5 F2
3 regulation of immune response GO:0050776 9.91 VCAM1 SELL ITGA4 ICAM1
4 blood coagulation GO:0007596 9.91 VWF PLAU PLAT F5 F2
5 cytokine-mediated signaling pathway GO:0019221 9.91 VEGFA VCAM1 TIMP1 MMP9 MMP1 IL1A
6 response to hypoxia GO:0001666 9.88 VEGFA VCAM1 PLAU PLAT MTHFR ICAM1
7 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.8 VEGFA SELP F2
8 extracellular matrix disassembly GO:0022617 9.77 TIMP1 MMP9 MMP1
9 hemostasis GO:0007599 9.76 VWF PLAU F5 F2
10 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.74 VCAM1 SELP ICAM1
11 leukocyte cell-cell adhesion GO:0007159 9.73 VCAM1 SELP ITGA4 ICAM1
12 cellular response to amyloid-beta GO:1904646 9.71 VCAM1 ITGA4 ICAM1
13 positive regulation of leukocyte migration GO:0002687 9.67 VEGFA SELP ITGA4
14 cellular response to UV-A GO:0071492 9.65 TIMP1 MMP9 MMP1
15 platelet degranulation GO:0002576 9.63 VWF VEGFA TIMP1 SERPINE1 SELP F5
16 plasminogen activation GO:0031639 9.62 PLAU PLAT
17 negative regulation of fibrinolysis GO:0051918 9.62 SERPINE1 F2
18 leukocyte tethering or rolling GO:0050901 9.62 VCAM1 SELP SELL ITGA4
19 positive regulation of leukocyte tethering or rolling GO:1903238 9.59 SELP ITGA4
20 smooth muscle cell migration GO:0014909 9.58 PLAU PLAT
21 membrane to membrane docking GO:0022614 9.56 VCAM1 ICAM1
22 fibrinolysis GO:0042730 9.56 SERPINE1 PLAU PLAT F2
23 connective tissue replacement involved in inflammatory response wound healing GO:0002248 9.55 TIMP1 IL1A
24 cell-cell adhesion in response to extracellular stimulus GO:0140039 9.52 VCAM1 ITGA4
25 leukocyte migration GO:0050900 9.5 SELP SELL MMP9 MMP1 ITGA4 ICAM1
26 extracellular matrix organization GO:0030198 9.23 VWF VCAM1 SERPINE1 MMP9 MMP1 ITGA4

Molecular functions related to Venous Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.8 PLAU PLAT MMP9 MMP1 F2
2 cytokine activity GO:0005125 9.67 VEGFA TIMP1 NDP IL1A
3 heparin binding GO:0008201 9.62 VEGFA SELP SELL F2
4 integrin binding GO:0005178 9.46 VWF VCAM1 ITGA4 ICAM1
5 oligosaccharide binding GO:0070492 9.43 SELP SELL
6 glycosphingolipid binding GO:0043208 9.26 SELP SELL
7 protease binding GO:0002020 9.26 VWF TIMP1 SERPINE1 SELL
8 serine-type endopeptidase activity GO:0004252 9.02 PLAU PLAT MMP9 MMP1 F2
Sources

Sources for Venous Insufficiency

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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