MCID: VNT032
MIFTS: 26

Ventricular Tachycardia, Familial

Categories: Genetic diseases, Rare diseases

Aliases & Classifications for Ventricular Tachycardia, Familial

MalaCards integrated aliases for Ventricular Tachycardia, Familial:

Name: Ventricular Tachycardia, Familial 58
Familial Ventricular Tachycardia 77 54 38 30 74
Ventricular Tachycardia, Familial Polymorphic 58 56
Ventricular Tachycardia, Idiopathic 58 13

Characteristics:

OMIM:

58
Inheritance:
autosomal dominant


HPO:

33
ventricular tachycardia, familial:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 58 192605
KEGG 38 H02269
MedGen 43 C0340485
UMLS 74 C0340485

Summaries for Ventricular Tachycardia, Familial

MalaCards based summary : Ventricular Tachycardia, Familial, also known as familial ventricular tachycardia, is related to catecholaminergic polymorphic ventricular tachycardia and ventricular fibrillation, paroxysmal familial, 1. An important gene associated with Ventricular Tachycardia, Familial is GNAI2 (G Protein Subunit Alpha I2), and among its related pathways/superpathways are DAG and IP3 signaling and Circadian entrainment. Related phenotypes are sudden cardiac death and abnormality of metabolism/homeostasis

Wikipedia : 77 Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited disorder that predisposes... more...

Description from OMIM: 192605

Related Diseases for Ventricular Tachycardia, Familial

Diseases related to Ventricular Tachycardia, Familial via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 catecholaminergic polymorphic ventricular tachycardia 11.8
2 ventricular fibrillation, paroxysmal familial, 1 9.9
3 giant cell myocarditis 9.9

Symptoms & Phenotypes for Ventricular Tachycardia, Familial

Human phenotypes related to Ventricular Tachycardia, Familial:

33
# Description HPO Frequency HPO Source Accession
1 sudden cardiac death 33 HP:0001645
2 abnormality of metabolism/homeostasis 33 HP:0001939
3 right bundle branch block 33 HP:0011712
4 paroxysmal ventricular tachycardia 33 HP:0004751

Symptoms via clinical synopsis from OMIM:

58
Cardiac:
sudden cardiac death
paroxysmal ventricular tachycardia
right bundle branch block with left axis deviation on ekg
no cardiomyopathy
no repolarization abnormality

Metabolic:
no metabolic disorder

Clinical features from OMIM:

192605

GenomeRNAi Phenotypes related to Ventricular Tachycardia, Familial according to GeneCards Suite gene sharing:

27 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-116 9.44 GNAI2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.44 GNAI2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.44 RYR2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-137 9.44 GNAI2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.44 RYR2
6 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.44 GNAI2
7 Increased shRNA abundance (Z-score > 2) GR00366-A-156 9.44 RYR2
8 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.44 RYR2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.44 GNAI2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-3 9.44 RYR2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.44 GNAI2 RYR2
12 Increased shRNA abundance (Z-score > 2) GR00366-A-77 9.44 GNAI2

MGI Mouse Phenotypes related to Ventricular Tachycardia, Familial:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.62 GNAI2 RYR2

Drugs & Therapeutics for Ventricular Tachycardia, Familial

Search Clinical Trials , NIH Clinical Center for Ventricular Tachycardia, Familial

Genetic Tests for Ventricular Tachycardia, Familial

Genetic tests related to Ventricular Tachycardia, Familial:

# Genetic test Affiliating Genes
1 Familial Ventricular Tachycardia 30 GNAI2

Anatomical Context for Ventricular Tachycardia, Familial

Publications for Ventricular Tachycardia, Familial

Articles related to Ventricular Tachycardia, Familial:

# Title Authors Year
1
Images in cardiology: familial ventricular tachycardia with mild ventricular dysfunction: a 15 year follow up of two African American brothers with arrhythmogenic right ventricular dysplasia. ( 11083749 )
2000
2
A case of familial ventricular tachycardia. ( 7602753 )
1995
3
Familial ventricular tachycardia: a report of four families. ( 2328167 )
1990

Variations for Ventricular Tachycardia, Familial

Expression for Ventricular Tachycardia, Familial

Search GEO for disease gene expression data for Ventricular Tachycardia, Familial.

Pathways for Ventricular Tachycardia, Familial

Pathways related to Ventricular Tachycardia, Familial according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.34 GNAI2 RYR2
2
Show member pathways
12.28 GNAI2 RYR2
3
Show member pathways
12.19 GNAI2 RYR2
4
Show member pathways
12.07 GNAI2 RYR2
5
Show member pathways
11.91 GNAI2 RYR2
6
Show member pathways
11.65 GNAI2 RYR2
7 11.28 GNAI2 RYR2
8 10.76 GNAI2 RYR2

GO Terms for Ventricular Tachycardia, Familial

Sources for Ventricular Tachycardia, Familial

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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