MCID: VRN001
MIFTS: 42

Vernal Conjunctivitis

Categories: Eye diseases

Aliases & Classifications for Vernal Conjunctivitis

MalaCards integrated aliases for Vernal Conjunctivitis:

Name: Vernal Conjunctivitis 12 15
Conjunctivitis, Vernal 74
Conjunctivitis Vernal 56

Classifications:



External Ids:

Disease Ontology 12 DOID:2474
ICD9CM 36 372.13
MeSH 45 D003233
NCIt 51 C34508
SNOMED-CT 69 20212001
ICD10 34 H10.44
UMLS 74 C0009773

Summaries for Vernal Conjunctivitis

MalaCards based summary : Vernal Conjunctivitis, also known as conjunctivitis, vernal, is related to giant papillary conjunctivitis and conjunctivitis. An important gene associated with Vernal Conjunctivitis is IL4 (Interleukin 4), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Hyaluronic acid and Histamine have been mentioned in the context of this disorder. Affiliated tissues include eye, t cells and skin, and related phenotypes are hematopoietic system and immune system

Related Diseases for Vernal Conjunctivitis

Diseases related to Vernal Conjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 143)
# Related Disease Score Top Affiliating Genes
1 giant papillary conjunctivitis 31.2 IL4 RNASE3
2 conjunctivitis 31.1 EPX IFNG IL2 IL4 MS4A2 RNASE3
3 hypereosinophilic syndrome 30.1 EPX IGHE IL2RA IL4 RNASE3
4 keratoconjunctivitis 29.9 AOC1 IFNG IL2 IL4 RNASE3
5 eosinophil peroxidase deficiency 10.4 EPX MPO
6 b-cell growth factor 10.4 IFNG IL4
7 eosinophilic granuloma 10.4 EPX RNASE3
8 papillary conjunctivitis 10.4
9 nickel allergic contact dermatitis 10.4 IFNG IL4
10 large granular lymphocyte leukemia 10.4 IFNG IL2RA
11 staphylococcal toxic shock syndrome 10.4 IFNG IGHE
12 baylisascariasis 10.4 IFNG IL4
13 penicillin allergy 10.4 IFNG IL4
14 scleritis 10.4 IFNG IL4
15 cough variant asthma 10.4 IL4 RNASE3
16 sulfamethoxazole allergy 10.4 IL4 MPO
17 maxillary sinusitis 10.4 MPO RNASE3
18 egg allergy 10.4 IGHE IL4
19 inflammatory bowel disease 4 10.4 EPX IL4 RNASE3
20 hyperlucent lung 10.4 IFNG IL2RA IL4
21 proliferative glomerulonephritis 10.3 IFNG IL4 MPO
22 pulmonary eosinophilia 10.3 EPX IL4 RNASE3
23 chronic rhinitis 10.3 EPX MPO
24 uveitis 10.3 IFNG IL2RA IL4
25 allergic conjunctivitis 10.3 IFNG IL4 RNASE3
26 folliculitis 10.3 IFNG IL2RA IL4
27 collagenous colitis 10.3 EPX MPO RNASE3
28 proctitis 10.3 EPX MPO RNASE3
29 hyper ige syndrome 10.3 IFNG IGHE IL4
30 virus associated hemophagocytic syndrome 10.3 IL2 IL4
31 crustacean allergy 10.3 IFNG IL4
32 latex allergy 10.3 IGHE IL4 RNASE3
33 variola major 10.3 IFNG IL2
34 autoimmune vasculitis 10.3 IL2 IL4
35 fixed drug eruption 10.3 IFNG IL2
36 toxocariasis 10.3 IGHE RNASE3
37 omenn syndrome 10.3 IFNG IGHE IL4
38 otitis media 10.3 IGHE IL4 RNASE3
39 intrinsic asthma 10.3 IL4 RNASE3
40 conjunctival disease 10.3 IL4 MS4A2 RNASE3
41 nasal cavity disease 10.3 IL4 MS4A2 RNASE3
42 hashimoto thyroiditis 10.3 IFNG IL2RA IL4
43 nose disease 10.3 IL4 MS4A2 RNASE3
44 graves' disease 10.3 IFNG IL2RA IL4
45 st. louis encephalitis 10.3 POMC RNASE3
46 cold urticaria 10.3 CMA1 RNASE3
47 blepharoconjunctivitis 10.3 CMA1 IL4 RNASE3
48 jak3-deficient severe combined immunodeficiency 10.3 IL2 IL4
49 adenohypophysitis 10.2 IL2RA POMC
50 chronic conjunctivitis 10.2 CMA1 IL4 RNASE3

Graphical network of the top 20 diseases related to Vernal Conjunctivitis:



Diseases related to Vernal Conjunctivitis

Symptoms & Phenotypes for Vernal Conjunctivitis

MGI Mouse Phenotypes related to Vernal Conjunctivitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.7 APP B2M CMA1 EPX IFNG IL2
2 immune system MP:0005387 9.36 APP B2M CMA1 EPX IFNG IL2

Drugs & Therapeutics for Vernal Conjunctivitis

Drugs for Vernal Conjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
2
Histamine Approved, Investigational Phase 4 51-45-6 774
3 Immunologic Factors Phase 4,Phase 2,Phase 3
4 Antirheumatic Agents Phase 4,Phase 2,Phase 3
5 Peripheral Nervous System Agents Phase 4
6 Histamine Antagonists Phase 4
7 Histamine H1 Antagonists Phase 4
8 Neurotransmitter Agents Phase 4
9 Analgesics Phase 4
10 Olopatadine Hydrochloride Phase 4
11 Anti-Inflammatory Agents Phase 4
12 Anti-Allergic Agents Phase 4
13 Analgesics, Non-Narcotic Phase 4
14 Viscosupplements Phase 4
15 Ophthalmic Solutions Phase 4
16 Adjuvants, Immunologic Phase 4
17 Protective Agents Phase 4
18 Pharmaceutical Solutions Phase 4
19 Histamine H1 Antagonists, Non-Sedating Phase 4
20 Anti-Inflammatory Agents, Non-Steroidal Phase 4
21
Histamine Phosphate Phase 4 51-74-1 65513
22
Miconazole Approved, Investigational, Vet_approved Phase 2, Phase 3 22916-47-8 4189
23 Anti-Infective Agents Phase 2, Phase 3
24 Dermatologic Agents Phase 2, Phase 3
25 Immunosuppressive Agents Phase 2, Phase 3
26 Calcineurin Inhibitors Phase 2, Phase 3
27 Antifungal Agents Phase 2, Phase 3
28 Cyclosporins Phase 2, Phase 3
29 Anti-Bacterial Agents
30 Antibiotics, Antitubercular

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Clinical Evaluation of Hylo-Dual Versus Patanol in Children With Seasonal Allergic Conjunctivitis Recruiting NCT03186755 Phase 4 Hyaluronic acid 0.05% & Ectoine 2.0%;Olopatadine hydrochloride ophthalmic solution 0.1%
2 Efficacy and Tolerance of Nova22007 Versus Vehicle in Patients With Vernal Keratoconjunctivitis (VKC) Completed NCT00328653 Phase 2, Phase 3 cyclosporine
3 China Red Eye Study on Allergic Conjunctivitis Active, not recruiting NCT03812952

Search NIH Clinical Center for Vernal Conjunctivitis

Genetic Tests for Vernal Conjunctivitis

Anatomical Context for Vernal Conjunctivitis

MalaCards organs/tissues related to Vernal Conjunctivitis:

42
Eye, T Cells, Skin, B Cells, Testes, Thyroid, Tonsil

Publications for Vernal Conjunctivitis

Articles related to Vernal Conjunctivitis:

(show top 50) (show all 74)
# Title Authors Year
1
Angiolymphoid Hyperplasia with Eosinophilia Accompanying Vernal Conjunctivitis. ( 27993267 )
2017
2
Component-resolved diagnostics in vernal conjunctivitis. ( 27454864 )
2016
3
Comment on: Systemic approach to managing vernal conjunctivitis in clinical practice and severity grading system and treatment algorithm. ( 27609172 )
2016
4
Component-resolved diagnostics in vernal conjunctivitis. ( 26342971 )
2015
5
The clinical significance of perilimbal conjunctival pigmentation in vernal conjunctivitis. ( 22237184 )
2012
6
The conjunctival flora in vernal conjunctivitis patients. ( 19845225 )
2009
7
Vernal conjunctivitis. ( 18282546 )
2008
8
Secondary bacterial keratitis associated with shield ulcer caused by vernal conjunctivitis. ( 17102679 )
2006
9
Acquired ptosis secondary to vernal conjunctivitis in young adults. ( 17117097 )
2006
10
Perilimbal bulbar conjunctival pigmentation in vernal conjunctivitis: prospective evaluation of a new clinical sign in an Indian population. ( 15097129 )
2004
11
Corneal hydrops associated with vernal conjunctivitis as a presenting sign of keratoconus in a Congolese child. ( 12058484 )
2002
12
The effect of BCG-PSN on T-cell subsets and cytokines in vernal conjunctivitis. ( 12658791 )
2002
13
Mitomycin-C and vernal conjunctivitis. ( 11097575 )
2000
14
Mitomycin-C and vernal conjunctivitis: Author's reply ( 11097577 )
2000
15
Mitomycin-C and vernal conjunctivitis: Author's reply ( 11097578 )
2000
16
Mitomycin-C and vernal conjunctivitis. ( 11097580 )
2000
17
Histamine effects on conjunctival fibroblasts from patients with vernal conjunctivitis. ( 10375437 )
1999
18
Efficacy of lodoxamide eye drops on tear fluid cytology of patients with vernal conjunctivitis. ( 10410789 )
1999
19
Identification of local Th2 and Th0 lymphocytes in vernal conjunctivitis by cytokine flow cytometry. ( 10549670 )
1999
20
Impression cytology of the conjunctival epithelium in patients with vernal conjunctivitis. ( 8763308 )
1996
21
Levocabastine eye drops in vernal conjunctivitis. ( 8963170 )
1995
22
Corneal hydrops associated with vernal conjunctivitis as a presenting sign of keratoconus in children. ( 9098316 )
1995
23
Levocabastine eye drops in the treatment of vernal conjunctivitis. ( 7835196 )
1994
24
Levels of prostaglandin E2 and leukotriene B4 in tears of vernal conjunctivitis patients during a therapeutic trial with indomethacin. ( 7924852 )
1994
25
Effectiveness of nedocromil sodium 2% eyedrops on clinical symptoms and tear fluid cytology of patients with vernal conjunctivitis. ( 1337745 )
1992
26
Conjunctival hyperresponsiveness to ocular histamine challenge in patients with vernal conjunctivitis. ( 1730830 )
1992
27
Detection by brush cytology of mast cells and eosinophils in allergic and vernal conjunctivitis. ( 1782781 )
1991
28
Terrien's marginal degeneration associated with vernal conjunctivitis. ( 2012162 )
1991
29
Accumulation of Th-2-like helper T cells in the conjunctiva of patients with vernal conjunctivitis. ( 1825106 )
1991
30
Human conjunctival mast cells: distribution of MCT and MCTC in vernal conjunctivitis and giant papillary conjunctivitis. ( 2196302 )
1990
31
Adjuvant therapy of aspirin and cromoglycate 2% eye drops in vernal conjunctivitis. ( 2507808 )
1989
32
Inferior corneal ulcers associated with palpebral vernal conjunctivitis. ( 3134817 )
1988
33
Tear lysozyme and lactoferrin levels in giant papillary conjunctivitis and vernal conjunctivitis. ( 3147820 )
1988
34
New immunological findings in vernal conjunctivitis. ( 3274676 )
1988
35
Efficacy of antiprostaglandin therapy in vernal conjunctivitis. ( 3115287 )
1987
36
Management of vernal conjunctivitis with steroid induced glaucoma--a comparative study. ( 3150371 )
1987
37
Vernal conjunctivitis--a cause of corneal mucoid plaques. ( 3744222 )
1986
38
Role of disodium cromoglycate in vernal conjunctivitis. ( 3939423 )
1985
39
Vernal conjunctivitis in the hyperimmunoglobulinemia E syndrome. ( 6240007 )
1984
40
Allergen-specific immunoglobulin E antibodies in tears and serum of vernal conjunctivitis patients. ( 6334034 )
1984
41
Long-term T-cell lines from the tears of patients with vernal conjunctivitis. ( 6335182 )
1984
42
Vernal conjunctivitis. Model studies in guinea pigs immunized topically with fluoresceinyl ovalbumin. ( 6497752 )
1984
43
Mucous membrane grafting for severe palpebral vernal conjunctivitis. ( 6508608 )
1984
44
Aspirin therapy in vernal conjunctivitis. ( 6573138 )
1983
45
Mucous membrane grafting for severe palpebral vernal conjunctivitis. ( 6651591 )
1983
46
IgG specific antibodies to rye grass and ragweed pollen antigens in the tear secretions of patients with vernal conjunctivitis. ( 6824048 )
1983
47
Density of goblet cells in vernal conjunctivitis and contact lens-associated giant papillary conjunctivitis. ( 7236092 )
1981
48
Mast cell ultrastructure. Comparison in contact lens-associated giant papillary conjunctivitis and vernal conjunctivitis. ( 7259602 )
1981
49
Studies on histamine and histaminase in spring catarrh (vernal conjunctivitis). ( 6782024 )
1981
50
Percentage of degranulated mast cells in vernal conjunctivitis and giant papillary conjunctivitis associated with contact-lens wear. ( 7234932 )
1981

Variations for Vernal Conjunctivitis

Expression for Vernal Conjunctivitis

Search GEO for disease gene expression data for Vernal Conjunctivitis.

Pathways for Vernal Conjunctivitis

Pathways related to Vernal Conjunctivitis according to GeneCards Suite gene sharing:

(show all 29)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.78 AOC1 APP B2M EPX IFNG IGHE
2
Show member pathways
13.23 B2M IFNG IGHE IL2 IL2RA IL4
3
Show member pathways
12.49 IFNG IGHE IL2 IL2RA IL4 MS4A2
4
Show member pathways
12.47 IFNG IL2 IL2RA IL4
5 12.4 B2M IFNG IL2 IL2RA IL4 MPO
6
Show member pathways
12.27 IFNG IL2 IL2RA IL4
7
Show member pathways
12.23 IFNG IL2 IL4 MPO
8
Show member pathways
12.13 IFNG IL2 IL2RA IL4
9
Show member pathways
11.98 CCL26 IFNG IL2 IL2RA IL4
10
Show member pathways
11.96 B2M EPX IFNG IL2 IL2RA IL4
11
Show member pathways
11.95 IFNG IL2 IL2RA
12
Show member pathways
11.91 APP IFNG IL4
13 11.88 IFNG IL2 IL4
14 11.84 IGHE IL4 POMC
15 11.75 IFNG IL2 IL2RA
16 11.74 IFNG IL2 IL4 POMC
17 11.72 IFNG IL2 IL2RA IL4 MPO
18 11.71 IFNG IL2 IL2RA IL4
19
Show member pathways
11.68 IFNG IL2 IL2RA IL4
20 11.63 CCL26 IFNG IL2 IL4
21
Show member pathways
11.61 B2M IFNG IL2 IL2RA IL4
22
Show member pathways
11.6 IL2 IL2RA IL4
23 11.56 CCL26 IGHE IL4
24
Show member pathways
11.52 B2M IFNG IL2 IL2RA
25 11.29 IFNG IL2 IL2RA IL4
26 11.2 IFNG IL2 IL4
27 11.17 IFNG IL2 IL2RA
28 11.13 IFNG IL2 IL4
29 10.78 IFNG IL2 IL2RA IL4

GO Terms for Vernal Conjunctivitis

Cellular components related to Vernal Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.77 AOC1 APP B2M CCL26 CMA1 EPX
2 external side of plasma membrane GO:0009897 9.56 B2M IGHE IL2RA MS4A2
3 extracellular region GO:0005576 9.47 AOC1 APP B2M CCL26 CMA1 EPX
4 secretory granule GO:0030141 9.33 CMA1 MPO POMC

Biological processes related to Vernal Conjunctivitis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.85 AOC1 B2M EPX MPO RNASE3
2 defense response to bacterium GO:0042742 9.8 EPX IGHE MPO RNASE3
3 regulation of signaling receptor activity GO:0010469 9.8 CCL26 IFNG IL2 IL4 POMC
4 response to oxidative stress GO:0006979 9.71 APP EPX MPO
5 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.65 IFNG IL2 IL4
6 cytokine-mediated signaling pathway GO:0019221 9.65 IGHE IL2 IL2RA IL4 POMC
7 positive regulation of T cell proliferation GO:0042102 9.61 IL2 IL2RA IL4
8 interleukin-2-mediated signaling pathway GO:0038110 9.52 IL2 IL2RA
9 positive regulation of isotype switching to IgG isotypes GO:0048304 9.51 IL2 IL4
10 negative regulation of lymphocyte proliferation GO:0050672 9.37 IL2 IL2RA
11 positive regulation of T cell differentiation GO:0045582 9.33 IL2 IL2RA IL4
12 regulation of T cell homeostatic proliferation GO:0046013 9.32 IL2 IL2RA
13 immune response GO:0006955 9.23 B2M CCL26 IFNG IGHE IL2 IL2RA
14 regulation of regulatory T cell differentiation GO:0045589 9.13 IFNG IL2 IL2RA

Molecular functions related to Vernal Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 CCL26 IFNG IL2 IL4

Sources for Vernal Conjunctivitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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