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MCID: VRN001
MIFTS: 34

Vernal Conjunctivitis

Categories: Neuronal diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Vernal Conjunctivitis

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MalaCards integrated aliases for Vernal Conjunctivitis:

Name: Vernal Conjunctivitis 12 15
Conjunctivitis, Vernal 70
Conjunctivitis Vernal 54

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:2474
ICD9CM 34 372.13
MeSH 44 D003233
NCIt 50 C34508
SNOMED-CT 67 193867003
ICD10 32 H10.44
UMLS 70 C0009773
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Summaries for Vernal Conjunctivitis

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MalaCards based summary : Vernal Conjunctivitis, also known as conjunctivitis, vernal, is related to conjunctivitis and giant papillary conjunctivitis. An important gene associated with Vernal Conjunctivitis is IL4 (Interleukin 4), and among its related pathways/superpathways are Innate Immune System and Allograft rejection. The drugs Clotrimazole and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include eye, t cells and thymus, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

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Related Diseases for Vernal Conjunctivitis

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Diseases related to Vernal Conjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 261)
# Related Disease Score Top Affiliating Genes
1 conjunctivitis 31.1 RNASE3 MPO IL4 IGHE IFNG
2 giant papillary conjunctivitis 31.1 RNASE3 IL4
3 vernal keratoconjunctivitis 30.7 RNASE3 IL4 IGHE
4 allergic conjunctivitis 30.4 RNASE3 IL4 IGHE IFNG
5 keratoconjunctivitis 30.2 RNASE3 MUC5AC IL4 IFNG
6 ige responsiveness, atopic 30.0 RNASE3 IL4 IGHE IFNG
7 eye disease 29.8 MUC5AC IL4 IFNG CCR6
8 graves' disease 29.7 MPO IL4 IL2RA IFNG
9 esophagitis, eosinophilic, 1 29.7 RNASE3 IL4 EPX CCR6
10 rhinitis 29.5 RNASE3 IL4 IGHE IFNG EPX
11 hyper ige syndrome 29.3 RNASE3 IL4 IGHE IFNG CCR6
12 hypereosinophilic syndrome 29.2 RNASE3 MPO IL4 IL2RA IGHE IFNG
13 papillary conjunctivitis 10.5
14 acute asthma 10.3 RNASE3 IL4
15 ifap syndrome 2 10.3
16 timothy grass allergy 10.3 RNASE3 IL4
17 chronic maxillary sinusitis 10.3 RNASE3 MPO
18 maxillary sinusitis 10.3 RNASE3 MPO
19 loeffler endocarditis 10.3 RNASE3 EPX
20 inflammatory bowel disease 4 10.3 RNASE3 EPX
21 elephantiasis 10.3 RNASE3 IL4
22 loiasis 10.3 IL4 EPX
23 adhesive otitis media 10.3 RNASE3 MPO
24 b-cell growth factor 10.3 IL4 IFNG
25 ocular cicatricial pemphigoid 10.3 RNASE3 IL4
26 pemphigoid 10.3 IL4 IFNG
27 patulous eustachian tube 10.3 RNASE3 MPO
28 eosinophil peroxidase deficiency 10.3 MPO EPX
29 orofacial granulomatosis 10.2 IL4 IFNG
30 keratoconus 10.2
31 eales disease 10.2 IL4 IFNG
32 retinitis pigmentosa 46 10.2 IL4 IFNG
33 nickel allergic contact dermatitis 10.2 IL4 IFNG
34 tungiasis 10.2 IL4 IFNG
35 mucocutaneous leishmaniasis 10.2 IL4 IFNG
36 anisakiasis 10.2 RNASE3 IGHE
37 dendritic cell tumor 10.2 MPO IFNG
38 idiopathic nephrotic syndrome 10.2 IL4 IGHE
39 paragonimiasis 10.2 RNASE3 IGHE
40 henoch-schoenlein purpura 10.2 RNASE3 MPO
41 beta-lactam allergy 10.2 IL4 IGHE
42 staphylococcal toxic shock syndrome 10.2 IGHE IFNG
43 eosinophilic meningitis 10.2 IL4 IGHE
44 microscopic colitis 10.2 IL4 IFNG
45 cysticercosis 10.2 IL4 IGHE
46 keratitis, hereditary 10.2
47 trachoma 10.2
48 conjunctival pigmentation 10.2
49 wells syndrome 10.1 RNASE3 IL2RA
50 chronic graft versus host disease 10.1 IL2RA IFNG

Graphical network of the top 20 diseases related to Vernal Conjunctivitis:



Diseases related to Vernal Conjunctivitis
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Symptoms & Phenotypes for Vernal Conjunctivitis

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GenomeRNAi Phenotypes related to Vernal Conjunctivitis according to GeneCards Suite gene sharing:

26 (show all 20)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-105 9.62 IL4
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 9.62 IL2RA
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-169 9.62 IL2RA
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-17 9.62 IL4
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-179 9.62 IL2RA
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-181 9.62 IL2RA
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-185 9.62 IL2RA
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-19 9.62 IL2RA
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-2 9.62 IL2RA
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-207 9.62 EPX
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.62 IL2RA
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.62 EPX
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-22 9.62 IL4
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-25 9.62 EPX
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-43 9.62 EPX
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-50 9.62 IL2RA
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.62 EPX
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-61 9.62 IL4
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-73 9.62 EPX
20 Decreased shRNA abundance (Z-score < -2) GR00366-A-9 9.62 IL2RA
Sources

Drugs & Therapeutics for Vernal Conjunctivitis

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Drugs for Vernal Conjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clotrimazole Approved, Vet_approved Phase 2, Phase 3 23593-75-1 2812
2
Miconazole Approved, Investigational, Vet_approved Phase 2, Phase 3 22916-47-8 4189
3 Anti-Infective Agents Phase 2, Phase 3
4 Immunosuppressive Agents Phase 2, Phase 3
5 Antirheumatic Agents Phase 2, Phase 3
6 Cyclosporins Phase 2, Phase 3
7 Immunologic Factors Phase 2, Phase 3
8 Calcineurin Inhibitors Phase 2, Phase 3
9 Dermatologic Agents Phase 2, Phase 3
10 Antifungal Agents Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II/III, Multicenter, Double-Masked, Randomized, Parallel Group, Dose Ranging, Controlled Trial of Efficacy and Tolerance of Nova22007 (Cyclosporine A [CSA] 0.05% & 0.1% Ophthalmic Cationic Emulsion) Versus Vehicle in Patients With VKC Completed NCT00328653 Phase 2, Phase 3 cyclosporine

Search NIH Clinical Center for Vernal Conjunctivitis

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Genetic Tests for Vernal Conjunctivitis

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Anatomical Context for Vernal Conjunctivitis

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MalaCards organs/tissues related to Vernal Conjunctivitis:

40
Eye, T Cells, Thymus
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Publications for Vernal Conjunctivitis

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Articles related to Vernal Conjunctivitis:

(show top 50) (show all 217)
# Title Authors PMID Year
1
The effect of BCG-PSN on T-cell subsets and cytokines in vernal conjunctivitis. 61 54
12658791 2002
2
Increased numbers of Th2-like CD4+ T cells in target organs and in the allergen-specific repertoire of allergic patients. Possible role of IL-4 produced by non-T cells. 54 61
1682270 1991
3
To evaluate the efficacy and safety of olopatadine 0.1% ophthalmic solution and bepotastine 1.5% ophthalmic solution in patients with vernal keratoconjunctivitis in a tertiary care hospital. 61
33666188 2020
4
Ocular allergy test and biomarkers on the ocular surface: Clinical test for evaluating the ocular surface condition in allergic conjunctival diseases. 61
32563624 2020
5
Diagnosing and managing allergic conjunctivitis in childhood: The allergist's perspective. 61
30742722 2019
6
[Application of corticosteroid eye drops for allergic eye diseases in children]. 61
30798620 2019
7
Bead Based Multiplex Assay for Analysis of Tear Cytokine Profiles. 61
29053687 2017
8
Sterile corneal infiltrates after corneal collagen cross-linking: evaluation of risk factors. 61
27775234 2017
9
Angiolymphoid Hyperplasia with Eosinophilia Accompanying Vernal Conjunctivitis. 61
27993267 2017
10
Unilateral tarsal amyloidosis. 61
27091291 2016
11
Component-resolved diagnostics in vernal conjunctivitis. 61
27454864 2016
12
An update on ocular allergy. 61
27490123 2016
13
Comment on: Systemic approach to managing vernal conjunctivitis in clinical practice and severity grading system and treatment algorithm. 61
27609172 2016
14
Outcome of Ocular Steroid Hypertensive Response in Children. 61
25651206 2016
15
Component-resolved diagnostics in vernal conjunctivitis. 61
26342971 2015
16
Patterns of presentations at a free eye clinic in an urban state hospital. 61
23563451 2013
17
Allergic conjunctivitis: a comprehensive review of the literature. 61
23497516 2013
18
Prevalence of eye diseases among school children in a rural south-eastern Nigerian community. 61
24093438 2013
19
Effect of mild conjunctivitis complication on tear balance in dry eye. 61
22580008 2012
20
[Treatment of eye allergies]. 61
22428383 2012
21
The clinical significance of perilimbal conjunctival pigmentation in vernal conjunctivitis. 61
22237184 2012
22
[Tropical endemic limboconjunctivitis (vernal conjunctivitis) in northern Cameroon]. 61
21183244 2011
23
Survey of pediatric ophthalmic diagnoses in a teaching hospital in Nigeria. 61
21970270 2011
24
Causes and prevalence of ocular morbidity among primary school children in Ilorin, Nigeria. 61
20857778 2010
25
[Trachoma in patients with allergic conjunctivitis]. 61
20730279 2010
26
[Eosinophilic inflammation in allergic diseases]. 61
21171247 2010
27
The management of allergic eye diseases in primary eye care. 61
19879797 2009
28
[Ophthalmology]. 61
19899534 2009
29
Ocular findings in children with nonsyndromic cleft lip and palate. 61
19950842 2009
30
Conjunctivitis and Total IgE in Lacrimal Fluid: Lacrytest Screening. 61
20975798 2009
31
The conjunctival flora in vernal conjunctivitis patients. 61
19845225 2009
32
Serum allergen specific immunoglobulin E levels in patients with allergic conjunctivitis. 61
18850541 2008
33
Vernal conjunctivitis. 61
18282546 2008
34
Prevalence of ocular disease in Tibetan primary school children. 61
18204497 2008
35
Unilateral vernal keratoconjunctivitis: a case report. 61
18050126 2007
36
Pattern of eye diseases and visual impairment among students in southwestern Nigeria. 61
17585376 2007
37
Prevalence of refractive error and other eye diseases in schoolchildren in the Greater Accra region of Ghana. 61
17913172 2007
38
Formulation of sirolimus eye drops and corneal permeation studies. 61
17593014 2007
39
Allergy and contact lenses. 61
17264492 2007
40
Acquired ptosis secondary to vernal conjunctivitis in young adults. 61
17117097 2006
41
Secondary bacterial keratitis associated with shield ulcer caused by vernal conjunctivitis. 61
17102679 2006
42
[Conjunctival provocation test: recommendations]. 61
16988636 2006
43
Blindness and low vision in Cape Verde Islands: results of a national eye survey. 61
16877280 2006
44
[Identification of adenovirus associated with conjunctivitis by molecular methodology]. 61
16888690 2006
45
A clinicopathological analysis of the efficacy of lodoxamide 0.1% eye drops on the conjunctiva of patients with vernal keratoconjunctivitis seen at Guinness Eye Centre, Lagos University Teaching Hospital. 61
16633377 2006
46
Tear cytokines in acute and chronic ocular allergic inflammation. 61
15349046 2004
47
Ocular allergic disease. 61
15349048 2004
48
Perilimbal bulbar conjunctival pigmentation in vernal conjunctivitis: prospective evaluation of a new clinical sign in an Indian population. 61
15097129 2004
49
[Allergic conditions of the eye]. 61
15347048 2004
50
Animal models of allergic and inflammatory conjunctivitis. 61
14616119 2003
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Variations for Vernal Conjunctivitis

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Expression for Vernal Conjunctivitis

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Search GEO for disease gene expression data for Vernal Conjunctivitis.
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Pathways for Vernal Conjunctivitis

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Pathways related to Vernal Conjunctivitis according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 12.92 RNASE3 MUC5AC MPO IL4 IL2RA IGHE
2
Allograft rejection 1 36
Show member pathways
 12.51 RNASE3 IL4 IL2RA IFNG EPX
3
Immune response NFAT in immune response 23
Show member pathways
 12.35 IL4 IL2RA IGHE IFNG
4
NF-kappaB Signaling 4
12.27 MPO IL4 IL2RA IFNG
5
IL-17 Family Signaling Pathways 64
Show member pathways
 12.08 MUC5AC IL4 IFNG
6
Folate Metabolism 1
Show member pathways
 12.07 MPO IL4 IFNG
7
IL12-mediated signaling events 1
Show member pathways
 11.71 IL4 IL2RA IFNG
8
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.52 MPO IL4 IL2RA IFNG
9
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.49 IL4 IL2RA IFNG
10
IgA-Producing B Cells in the Intestine 64
11.4 IL4 IL2RA CCR6
11
Th2 Differentiation Pathway 64
11.16 IL4 IL2RA IFNG
12
Innate Lymphoid Cell Differentiation Pathways 64
11.16 IL4 IL2RA IFNG CCR6
13
IL-15 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types 64
Show member pathways
 11.14 IL2RA IFNG
14
Development and heterogeneity of the ILC family 1
11.08 IL4 IFNG
15
Immune response_IL-12 signaling pathway 23
Show member pathways
 11.01 IL2RA IFNG
16
Cytokines and Inflammatory Response 1
11 IL4 IFNG
17
IL12 signaling mediated by STAT4 1
10.97 IL2RA IFNG
18
Inflammatory Response Pathway 1
10.95 IL4 IL2RA IFNG
19
OX40 Pathway 63
10.93 IL4 IFNG
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GO Terms for Vernal Conjunctivitis

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Cellular components related to Vernal Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 RNASE3 MUC5AC MPO IL4 IFNG EPX
2 extracellular region GO:0005576 9.23 RNASE3 MUC5AC MPO IL4 IGHE IFNG

Biological processes related to Vernal Conjunctivitis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.71 RNASE3 MPO EPX AOC1
2 defense response to bacterium GO:0042742 9.56 RNASE3 MPO IGHE EPX
3 positive regulation of epithelial cell migration GO:0010634 9.51 IFNG CCR6
4 microglial cell activation GO:0001774 9.49 IL4 IFNG
5 hydrogen peroxide catabolic process GO:0042744 9.48 MPO EPX
6 innate immune response in mucosa GO:0002227 9.46 RNASE3 IL4
7 positive regulation of T cell differentiation GO:0045582 9.43 IL4 IL2RA
8 regulation of regulatory T cell differentiation GO:0045589 9.37 IL2RA IFNG
9 positive regulation of MHC class II biosynthetic process GO:0045348 9.32 IL4 IFNG
10 positive regulation of cellular respiration GO:1901857 9.16 IL4 IFNG
11 immune response GO:0006955 9.02 IL4 IL2RA IGHE IFNG CCR6
12 neuroinflammatory response GO:0150076 8.96 IL4 IFNG
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Sources for Vernal Conjunctivitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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