MCID: VRN001
MIFTS: 42

Vernal Conjunctivitis

Categories: Eye diseases

Aliases & Classifications for Vernal Conjunctivitis

MalaCards integrated aliases for Vernal Conjunctivitis:

Name: Vernal Conjunctivitis 12 15
Conjunctivitis, Vernal 73
Conjunctivitis Vernal 55

Classifications:



External Ids:

Disease Ontology 12 DOID:2474
ICD10 33 H10.44
ICD9CM 35 372.13
MeSH 44 D003233
NCIt 50 C34508
SNOMED-CT 68 20212001
UMLS 73 C0009773

Summaries for Vernal Conjunctivitis

MalaCards based summary : Vernal Conjunctivitis, also known as conjunctivitis, vernal, is related to conjunctivitis and giant papillary conjunctivitis. An important gene associated with Vernal Conjunctivitis is IL4 (Interleukin 4), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. Affiliated tissues include eye, t cells and lung, and related phenotypes are hematopoietic system and homeostasis/metabolism

Related Diseases for Vernal Conjunctivitis

Diseases related to Vernal Conjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 146)
# Related Disease Score Top Affiliating Genes
1 conjunctivitis 31.2 EPX IFNG IL2 IL4 MS4A2 RNASE3
2 giant papillary conjunctivitis 31.0 IL4 RNASE3
3 papillary conjunctivitis 10.4
4 autoimmune myocarditis 10.3 IFNG IL4
5 eosinophil peroxidase deficiency 10.3 EPX MPO
6 b-cell growth factor 10.3 IFNG IL4
7 eosinophilic granuloma 10.3 EPX RNASE3
8 nickel allergic contact dermatitis 10.3 IFNG IL4
9 staphylococcal toxic shock syndrome 10.3 IFNG IGHE
10 large granular lymphocyte leukemia 10.3 IFNG IL2RA
11 baylisascariasis 10.3 IFNG IL4
12 cough variant asthma 10.3 IL4 RNASE3
13 penicillin allergy 10.3 IFNG IL4
14 scleritis 10.3 IFNG IL4
15 inflammatory bowel disease 4 10.2 EPX IL4 RNASE3
16 hyperlucent lung 10.2 IFNG IL2RA IL4
17 proliferative glomerulonephritis 10.2 IFNG IL4 MPO
18 pulmonary eosinophilia 10.2 EPX IL4 RNASE3
19 uveitis 10.2 IFNG IL2RA IL4
20 folliculitis 10.2 IFNG IL2RA IL4
21 maxillary sinusitis 10.2 MPO RNASE3
22 allergic conjunctivitis 10.2 IFNG IL4 RNASE3
23 sulfamethoxazole allergy 10.2 IL4 MPO
24 collagenous colitis 10.2 EPX MPO RNASE3
25 egg allergy 10.2 IGHE IL4
26 pollen allergy 10.2 EPX MPO RNASE3
27 hyper ige syndrome 10.2 IFNG IGHE IL4
28 proctitis 10.2 EPX MPO RNASE3
29 latex allergy 10.2 IGHE IL4 RNASE3
30 chronic rhinitis 10.2 EPX MPO
31 conjunctival disease 10.2 IL4 MS4A2 RNASE3
32 omenn syndrome 10.2 IFNG IGHE IL4
33 otitis media 10.2 IGHE IL4 RNASE3
34 nasal cavity disease 10.2 IL4 MS4A2 RNASE3
35 nose disease 10.2 IL4 MS4A2 RNASE3
36 crustacean allergy 10.2 IFNG IL4
37 virus associated hemophagocytic syndrome 10.2 IL2 IL4
38 blepharoconjunctivitis 10.2 CMA1 IL4 RNASE3
39 toxocariasis 10.2 IGHE RNASE3
40 variola major 10.2 IFNG IL2
41 glaucoma, normal tension 10.2 LOXL1 OPTN
42 chronic conjunctivitis 10.2 CMA1 IL4 RNASE3
43 hashimoto thyroiditis 10.2 IFNG IL2RA IL4
44 churg-strauss syndrome 10.2 CCL26 MPO RNASE3
45 keratoconus 10.2
46 conjunctival pigmentation 10.2
47 cold urticaria 10.2 CMA1 RNASE3
48 autoimmune vasculitis 10.2 IL2 IL4
49 fixed drug eruption 10.2 IFNG IL2
50 urinary schistosomiasis 10.2 EPX IFNG IL4 RNASE3

Graphical network of the top 20 diseases related to Vernal Conjunctivitis:



Diseases related to Vernal Conjunctivitis

Symptoms & Phenotypes for Vernal Conjunctivitis

MGI Mouse Phenotypes related to Vernal Conjunctivitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.93 AOC1 B2M CMA1 EPX IFNG IL2
2 homeostasis/metabolism MP:0005376 9.7 AOC1 B2M IFNG IL2 IL2RA IL4
3 immune system MP:0005387 9.36 B2M CMA1 EPX IFNG IL2 IL2RA

Drugs & Therapeutics for Vernal Conjunctivitis

Search Clinical Trials , NIH Clinical Center for Vernal Conjunctivitis

Genetic Tests for Vernal Conjunctivitis

Anatomical Context for Vernal Conjunctivitis

MalaCards organs/tissues related to Vernal Conjunctivitis:

41
Eye, T Cells, Lung, Skin, Bone, Thyroid, B Cells

Publications for Vernal Conjunctivitis

Articles related to Vernal Conjunctivitis:

(show top 50) (show all 73)
# Title Authors Year
1
Angiolymphoid Hyperplasia with Eosinophilia Accompanying Vernal Conjunctivitis. ( 27993267 )
2017
2
Comment on: Systemic approach to managing vernal conjunctivitis in clinical practice and severity grading system and treatment algorithm. ( 27609172 )
2016
3
Component-resolved diagnostics in vernal conjunctivitis. ( 27454864 )
2016
4
Component-resolved diagnostics in vernal conjunctivitis. ( 26342971 )
2015
5
The clinical significance of perilimbal conjunctival pigmentation in vernal conjunctivitis. ( 22237184 )
2012
6
The conjunctival flora in vernal conjunctivitis patients. ( 19845225 )
2009
7
Vernal conjunctivitis. ( 18282546 )
2008
8
Acquired ptosis secondary to vernal conjunctivitis in young adults. ( 17117097 )
2006
9
Secondary bacterial keratitis associated with shield ulcer caused by vernal conjunctivitis. ( 17102679 )
2006
10
Perilimbal bulbar conjunctival pigmentation in vernal conjunctivitis: prospective evaluation of a new clinical sign in an Indian population. ( 15097129 )
2004
11
The effect of BCG-PSN on T-cell subsets and cytokines in vernal conjunctivitis. ( 12658791 )
2002
12
Corneal hydrops associated with vernal conjunctivitis as a presenting sign of keratoconus in a Congolese child. ( 12058484 )
2002
13
Mitomycin-C and vernal conjunctivitis. ( 11097580 )
2000
14
Mitomycin-C and vernal conjunctivitis. ( 11097575 )
2000
15
Mitomycin-C and vernal conjunctivitis: Author's reply ( 11097578 )
2000
16
Mitomycin-C and vernal conjunctivitis: Author's reply ( 11097577 )
2000
17
Histamine effects on conjunctival fibroblasts from patients with vernal conjunctivitis. ( 10375437 )
1999
18
Efficacy of lodoxamide eye drops on tear fluid cytology of patients with vernal conjunctivitis. ( 10410789 )
1999
19
Impression cytology of the conjunctival epithelium in patients with vernal conjunctivitis. ( 8763308 )
1996
20
Corneal hydrops associated with vernal conjunctivitis as a presenting sign of keratoconus in children. ( 9098316 )
1995
21
Levocabastine eye drops in vernal conjunctivitis. ( 8963170 )
1995
22
Levels of prostaglandin E2 and leukotriene B4 in tears of vernal conjunctivitis patients during a therapeutic trial with indomethacin. ( 7924852 )
1994
23
Levocabastine eye drops in the treatment of vernal conjunctivitis. ( 7835196 )
1994
24
Conjunctival hyperresponsiveness to ocular histamine challenge in patients with vernal conjunctivitis. ( 1730830 )
1992
25
Effectiveness of nedocromil sodium 2% eyedrops on clinical symptoms and tear fluid cytology of patients with vernal conjunctivitis. ( 1337745 )
1992
26
Accumulation of Th-2-like helper T cells in the conjunctiva of patients with vernal conjunctivitis. ( 1825106 )
1991
27
Terrien's marginal degeneration associated with vernal conjunctivitis. ( 2012162 )
1991
28
Detection by brush cytology of mast cells and eosinophils in allergic and vernal conjunctivitis. ( 1782781 )
1991
29
Human conjunctival mast cells: distribution of MCT and MCTC in vernal conjunctivitis and giant papillary conjunctivitis. ( 2196302 )
1990
30
Adjuvant therapy of aspirin and cromoglycate 2% eye drops in vernal conjunctivitis. ( 2507808 )
1989
31
Inferior corneal ulcers associated with palpebral vernal conjunctivitis. ( 3134817 )
1988
32
Tear lysozyme and lactoferrin levels in giant papillary conjunctivitis and vernal conjunctivitis. ( 3147820 )
1988
33
New immunological findings in vernal conjunctivitis. ( 3274676 )
1988
34
Management of vernal conjunctivitis with steroid induced glaucoma--a comparative study. ( 3150371 )
1987
35
Efficacy of antiprostaglandin therapy in vernal conjunctivitis. ( 3115287 )
1987
36
Vernal conjunctivitis--a cause of corneal mucoid plaques. ( 3744222 )
1986
37
Role of disodium cromoglycate in vernal conjunctivitis. ( 3939423 )
1985
38
Vernal conjunctivitis. Model studies in guinea pigs immunized topically with fluoresceinyl ovalbumin. ( 6497752 )
1984
39
Allergen-specific immunoglobulin E antibodies in tears and serum of vernal conjunctivitis patients. ( 6334034 )
1984
40
Mucous membrane grafting for severe palpebral vernal conjunctivitis. ( 6508608 )
1984
41
Vernal conjunctivitis in the hyperimmunoglobulinemia E syndrome. ( 6240007 )
1984
42
Long-term T-cell lines from the tears of patients with vernal conjunctivitis. ( 6335182 )
1984
43
Aspirin therapy in vernal conjunctivitis. ( 6573138 )
1983
44
Mucous membrane grafting for severe palpebral vernal conjunctivitis. ( 6651591 )
1983
45
IgG specific antibodies to rye grass and ragweed pollen antigens in the tear secretions of patients with vernal conjunctivitis. ( 6824048 )
1983
46
Percentage of degranulated mast cells in vernal conjunctivitis and giant papillary conjunctivitis associated with contact-lens wear. ( 7234932 )
1981
47
Density of goblet cells in vernal conjunctivitis and contact lens-associated giant papillary conjunctivitis. ( 7236092 )
1981
48
Mast cell ultrastructure. Comparison in contact lens-associated giant papillary conjunctivitis and vernal conjunctivitis. ( 7259602 )
1981
49
Studies on histamine and histaminase in spring catarrh (vernal conjunctivitis). ( 6782024 )
1981
50
Tear histamine levels in vernal conjunctivitis and other ocular inflammations. ( 7443214 )
1980

Variations for Vernal Conjunctivitis

Expression for Vernal Conjunctivitis

Search GEO for disease gene expression data for Vernal Conjunctivitis.

Pathways for Vernal Conjunctivitis

Pathways related to Vernal Conjunctivitis according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.92 AOC1 B2M EPX IFNG IGHE IL2
2
Show member pathways
13.25 B2M IFNG IGHE IL2 IL2RA IL4
3
Show member pathways
12.49 IFNG IGHE IL2 IL2RA IL4 MS4A2
4
Show member pathways
12.47 IFNG IL2 IL2RA IL4
5 12.36 B2M IFNG IL2 IL2RA IL4 MPO
6
Show member pathways
12.27 IFNG IL2 IL2RA IL4
7
Show member pathways
12.22 IFNG IL2 IL4 MPO
8
Show member pathways
12.13 IFNG IL2 IL2RA IL4
9
Show member pathways
11.98 CCL26 IFNG IL2 IL2RA IL4
10
Show member pathways
11.96 B2M EPX IFNG IL2 IL2RA IL4
11 11.87 IFNG IL2 IL4
12 11.84 IGHE IL4 POMC
13 11.75 IFNG IL2 IL2RA
14 11.73 IFNG IL2 IL4 POMC
15 11.72 IFNG IL2 IL2RA IL4 MPO
16 11.7 IFNG IL2 IL2RA IL4
17
Show member pathways
11.66 IFNG IL2 IL2RA IL4
18
Show member pathways
11.61 B2M IFNG IL2 IL2RA IL4
19
Show member pathways
11.59 IL2 IL2RA IL4
20 11.59 CCL26 IFNG IL2 IL4
21 11.55 CCL26 IGHE IL4
22
Show member pathways
11.49 B2M IFNG IL2 IL2RA
23 11.29 IFNG IL2 IL2RA IL4
24 11.2 IFNG IL2 IL4
25 11.16 IFNG IL2 IL2RA
26 11.12 IFNG IL2 IL4
27 10.78 IFNG IL2 IL2RA IL4

GO Terms for Vernal Conjunctivitis

Cellular components related to Vernal Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 AOC1 B2M CCL26 CMA1 EPX IFNG
2 external side of plasma membrane GO:0009897 9.67 B2M IGHE IL2RA MS4A2
3 secretory granule lumen GO:0034774 9.5 EPX POMC TF
4 extracellular space GO:0005615 9.44 AOC1 B2M CCL26 CMA1 EPX IFNG
5 secretory granule GO:0030141 9.43 CMA1 MPO POMC
6 HFE-transferrin receptor complex GO:1990712 9.16 B2M TF

Biological processes related to Vernal Conjunctivitis according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.96 B2M IGHE IL2 IL2RA OPTN
2 neutrophil degranulation GO:0043312 9.89 AOC1 B2M EPX MPO RNASE3
3 regulation of signaling receptor activity GO:0010469 9.88 CCL26 IFNG IL2 IL4 POMC
4 defense response to bacterium GO:0042742 9.84 EPX IGHE MPO RNASE3
5 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.69 IFNG IL2 IL4
6 cytokine-mediated signaling pathway GO:0019221 9.65 IGHE IL2 IL2RA IL4 POMC
7 positive regulation of T cell proliferation GO:0042102 9.61 IL2 IL2RA IL4
8 iron ion transport GO:0006826 9.57 B2M TF
9 interleukin-2-mediated signaling pathway GO:0038110 9.55 IL2 IL2RA
10 positive regulation of isotype switching to IgG isotypes GO:0048304 9.52 IL2 IL4
11 cellular response to iron ion GO:0071281 9.46 B2M TF
12 negative regulation of lymphocyte proliferation GO:0050672 9.4 IL2 IL2RA
13 regulation of iron ion import GO:1900390 9.37 B2M TF
14 positive regulation of T cell differentiation GO:0045582 9.33 IL2 IL2RA IL4
15 regulation of T cell homeostatic proliferation GO:0046013 9.32 IL2 IL2RA
16 immune response GO:0006955 9.23 B2M CCL26 IFNG IGHE IL2 IL2RA
17 regulation of regulatory T cell differentiation GO:0045589 9.13 IFNG IL2 IL2RA

Molecular functions related to Vernal Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 CCL26 IFNG IL2 IL4

Sources for Vernal Conjunctivitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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