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MCID: VRN001
MIFTS: 30

Vernal Conjunctivitis

Categories: Neuronal diseases
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Aliases & Classifications for Vernal Conjunctivitis

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MalaCards integrated aliases for Vernal Conjunctivitis:

Name: Vernal Conjunctivitis 11 14
Conjunctivitis, Vernal 71
Conjunctivitis Vernal 53

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 11 DOID:2474
ICD9CM 34 372.13
MeSH 43 D003233
NCIt 49 C34508
SNOMED-CT 68 193867003
UMLS 71 C0009773
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Summaries for Vernal Conjunctivitis

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MalaCards based summary: Vernal Conjunctivitis, also known as conjunctivitis, vernal, is related to vernal keratoconjunctivitis and papillary conjunctivitis. An important gene associated with Vernal Conjunctivitis is IL4 (Interleukin 4), and among its related pathways/superpathways are CLEC7A (Dectin-1) signaling and IL4-mediated signaling events. The drugs Histamine and Hyaluronic acid have been mentioned in the context of this disorder. Affiliated tissues include eye, t cells and thymus.
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Related Diseases for Vernal Conjunctivitis

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Diseases related to Vernal Conjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 102)
# Related Disease Score Top Affiliating Genes
1 vernal keratoconjunctivitis 30.7 IL4 CCL11
2 papillary conjunctivitis 30.6 MUC5AC IL4 CCL11
3 giant papillary conjunctivitis 30.6 MUC5AC IL4 CCL11
4 allergic conjunctivitis 30.5 MUC5AC IL4 CCL11
5 keratoconjunctivitis 30.4 MUC5AC IL4 CCL11
6 chronic rhinitis 30.2 PDCL IL4
7 ascaris lumbricoides infection 30.2 IL4 COPS7A
8 eosinophilic gastroenteritis 30.1 IL4 CCL11
9 corneal ulcer 30.0 MUC5AC CCL11
10 esophagitis, eosinophilic, 1 30.0 IL4 CCL11
11 rhinitis 29.7 IL4 CYSLTR1 CCL11 AOC1
12 asthma 28.8 MUC5AC IL4 CYSLTR2 CYSLTR1 CMA1 CCL11
13 conjunctivitis 11.1
14 keratoconus 10.2
15 eye disease 10.2
16 hypereosinophilic syndrome 10.2
17 adenoid hypertrophy 10.2 IL4 CYSLTR1
18 keratoconjunctivitis sicca 10.2 MUC5AC IL4
19 blepharitis 10.2 MUC5AC IL4
20 eyelid disease 10.2 MUC5AC IL4
21 thunderstorm triggered asthma 10.2 PDCL IL4
22 ige responsiveness, atopic 10.2
23 keratitis, hereditary 10.2
24 trachoma 10.2
25 conjunctival pigmentation 10.2
26 lacrimal apparatus disease 10.2 MUC5AC IL4
27 aspirin-induced respiratory disease 10.2 CYSLTR2 CYSLTR1
28 persistent mild asthma 10.1 CYSLTR2 CYSLTR1
29 egg allergy 10.1 PDCL IL4
30 asthma, nasal polyps, and aspirin intolerance 10.1 CYSLTR2 CYSLTR1
31 legume allergy 10.1 PDCL IL4
32 fruit allergy 10.1 PDCL IL4
33 peanut allergy 10.1 PDCL IL4
34 middle ear disease 10.1 MUC5AC IL4
35 loiasis 10.1 IL4 CCL11
36 eosinophilic meningitis 10.1 IL4 CCL11
37 trichinosis 10.1 IL4 CCL11
38 occupational asthma 10.1 IL4 CCL11
39 environmental induced asthma 10.0 IL4 CCL11
40 tomato allergy 10.0 PDCL COPS7A
41 crustacean allergy 10.0 PDCL COPS7A
42 shrimp allergy 10.0 PDCL COPS7A
43 strongyloidiasis 10.0 IL4 CCL11
44 wheat allergy 10.0 PDCL COPS7A
45 melon allergy 10.0 PDCL COPS7A
46 exercise-induced bronchoconstriction 10.0 IL4 CYSLTR2 CYSLTR1
47 latex allergy 10.0 PDCL COPS7A
48 phenytoin allergy 10.0 CMA1 CCL11
49 photoparoxysmal response 1 10.0
50 graves disease 1 10.0

Graphical network of the top 20 diseases related to Vernal Conjunctivitis:



Diseases related to Vernal Conjunctivitis
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Symptoms & Phenotypes for Vernal Conjunctivitis

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Drugs & Therapeutics for Vernal Conjunctivitis

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Drugs for Vernal Conjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Histamine Approved, Investigational Phase 4 51-45-6 774
2
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
3 Antirheumatic Agents Phase 4
4 Neurotransmitter Agents Phase 4
5 Adjuvants, Immunologic Phase 4
6 Anti-Allergic Agents Phase 4
7 Viscosupplements Phase 4
8 Anti-Inflammatory Agents, Non-Steroidal Phase 4
9
Histamine phosphate Phase 4 51-74-1 134614
10 Ophthalmic Solutions Phase 4
11 Histamine H1 Antagonists, Non-Sedating Phase 4
12 Histamine H1 Antagonists Phase 4
13 Pharmaceutical Solutions Phase 4
14 Histamine Antagonists Phase 4
15 Analgesics, Non-Narcotic Phase 4
16 Anti-Inflammatory Agents Phase 4
17 Analgesics Phase 4
18
Olopatadine Hydrochloride Phase 4 140462-76-6
19 Immunologic Factors Phase 4
20 Protective Agents Phase 4
21
Miconazole Approved, Investigational, Vet_approved Phase 2, Phase 3 22916-47-8 4189
22
Clotrimazole Approved, Vet_approved Phase 2, Phase 3 23593-75-1 2812
23 Anti-Infective Agents Phase 2, Phase 3
24 Calcineurin Inhibitors Phase 2, Phase 3
25 Cyclosporins Phase 2, Phase 3
26 Antifungal Agents Phase 2, Phase 3
27 Immunosuppressive Agents Phase 2, Phase 3
28 Dermatologic Agents Phase 2, Phase 3
29 Hormones

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized Controlled Trial Comparing Olopatadine 0.1% Ophthalmic Solution With Hylo-Dual Ophthalmic Preparation in Children With Seasonal Allergic Conjunctivitis Recruiting NCT03186755 Phase 4 Hyaluronic acid 0.05% & Ectoine 2.0%;Olopatadine hydrochloride ophthalmic solution 0.1%
2 Phase II/III, Multicenter, Double-Masked, Randomized, Parallel Group, Dose Ranging, Controlled Trial of Efficacy and Tolerance of Nova22007 (Cyclosporine A [CSA] 0.05% & 0.1% Ophthalmic Cationic Emulsion) Versus Vehicle in Patients With VKC Completed NCT00328653 Phase 2, Phase 3 Cyclosporine NOVA22007 0.05%;Cyclosporine NOVA22007 0.1%;Vehicle
3 HORMONAL ROLE IN VERNAL KERATOCONJUNCTIVITIS Completed NCT05038241

Search NIH Clinical Center for Vernal Conjunctivitis

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Genetic Tests for Vernal Conjunctivitis

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Anatomical Context for Vernal Conjunctivitis

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Organs/tissues related to Vernal Conjunctivitis:

MalaCards : Eye, T Cells, Thymus
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Publications for Vernal Conjunctivitis

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Articles related to Vernal Conjunctivitis:

(show top 50) (show all 220)
# Title Authors PMID Year
1
The effect of BCG-PSN on T-cell subsets and cytokines in vernal conjunctivitis. 53 62
12658791 2002
2
Increased numbers of Th2-like CD4+ T cells in target organs and in the allergen-specific repertoire of allergic patients. Possible role of IL-4 produced by non-T cells. 53 62
1682270 1991
3
Biologics for allergy: therapeutic potential for ocular allergic diseases and adverse effects on the eye. 62
36333219 2022
4
Allergic Conjunctivitis: An Update. 62
34136960 2022
5
Acute Corneal Hydrops in Keratoconus Patients with Graves' Orbitopathy. 62
35059583 2021
6
To evaluate the efficacy and safety of olopatadine 0.1% ophthalmic solution and bepotastine 1.5% ophthalmic solution in patients with vernal keratoconjunctivitis in a tertiary care hospital. 62
33666188 2020
7
Ocular allergy test and biomarkers on the ocular surface: Clinical test for evaluating the ocular surface condition in allergic conjunctival diseases. 62
32563624 2020
8
Diagnosing and managing allergic conjunctivitis in childhood: The allergist's perspective. 62
30742722 2019
9
[Application of corticosteroid eye drops for allergic eye diseases in children]. 62
30798620 2019
10
Bead Based Multiplex Assay for Analysis of Tear Cytokine Profiles. 62
29053687 2017
11
Sterile corneal infiltrates after corneal collagen cross-linking: evaluation of risk factors. 62
27775234 2017
12
Angiolymphoid Hyperplasia with Eosinophilia Accompanying Vernal Conjunctivitis. 62
27993267 2017
13
Unilateral tarsal amyloidosis. 62
27091291 2016
14
Component-resolved diagnostics in vernal conjunctivitis. 62
27454864 2016
15
An update on ocular allergy. 62
27490123 2016
16
Comment on: Systemic approach to managing vernal conjunctivitis in clinical practice and severity grading system and treatment algorithm. 62
27609172 2016
17
Outcome of Ocular Steroid Hypertensive Response in Children. 62
25651206 2016
18
Component-resolved diagnostics in vernal conjunctivitis. 62
26342971 2015
19
Patterns of presentations at a free eye clinic in an urban state hospital. 62
23563451 2013
20
Allergic conjunctivitis: a comprehensive review of the literature. 62
23497516 2013
21
Prevalence of eye diseases among school children in a rural south-eastern Nigerian community. 62
24093438 2013
22
Effect of mild conjunctivitis complication on tear balance in dry eye. 62
22580008 2012
23
[Treatment of eye allergies]. 62
22428383 2012
24
The clinical significance of perilimbal conjunctival pigmentation in vernal conjunctivitis. 62
22237184 2012
25
[Tropical endemic limboconjunctivitis (vernal conjunctivitis) in northern Cameroon]. 62
21183244 2011
26
Survey of pediatric ophthalmic diagnoses in a teaching hospital in Nigeria. 62
21970270 2011
27
Causes and prevalence of ocular morbidity among primary school children in Ilorin, Nigeria. 62
20857778 2010
28
[Trachoma in patients with allergic conjunctivitis]. 62
20730279 2010
29
[Eosinophilic inflammation in allergic diseases]. 62
21171247 2010
30
The management of allergic eye diseases in primary eye care. 62
19879797 2009
31
[Ophthalmology]. 62
19899534 2009
32
Ocular findings in children with nonsyndromic cleft lip and palate. 62
19950842 2009
33
Conjunctivitis and Total IgE in Lacrimal Fluid: Lacrytest Screening. 62
20975798 2009
34
The conjunctival flora in vernal conjunctivitis patients. 62
19845225 2009
35
Serum allergen specific immunoglobulin E levels in patients with allergic conjunctivitis. 62
18850541 2008
36
Vernal conjunctivitis. 62
18282546 2008
37
Prevalence of ocular disease in Tibetan primary school children. 62
18204497 2008
38
Unilateral vernal keratoconjunctivitis: a case report. 62
18050126 2007
39
Pattern of eye diseases and visual impairment among students in southwestern Nigeria. 62
17585376 2007
40
Prevalence of refractive error and other eye diseases in schoolchildren in the Greater Accra region of Ghana. 62
17913172 2007
41
Formulation of sirolimus eye drops and corneal permeation studies. 62
17593014 2007
42
Allergy and contact lenses. 62
17264492 2007
43
Acquired ptosis secondary to vernal conjunctivitis in young adults. 62
17117097 2006
44
Secondary bacterial keratitis associated with shield ulcer caused by vernal conjunctivitis. 62
17102679 2006
45
[Conjunctival provocation test: recommendations]. 62
16988636 2006
46
Blindness and low vision in Cape Verde Islands: results of a national eye survey. 62
16877280 2006
47
[Identification of adenovirus associated with conjunctivitis by molecular methodology]. 62
16888690 2006
48
A clinicopathological analysis of the efficacy of lodoxamide 0.1% eye drops on the conjunctiva of patients with vernal keratoconjunctivitis seen at Guinness Eye Centre, Lagos University Teaching Hospital. 62
16633377 2006
49
Tear cytokines in acute and chronic ocular allergic inflammation. 62
15349046 2004
50
Ocular allergic disease. 62
15349048 2004
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Variations for Vernal Conjunctivitis

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Expression for Vernal Conjunctivitis

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Search GEO for disease gene expression data for Vernal Conjunctivitis.
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Pathways for Vernal Conjunctivitis

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Pathways related to Vernal Conjunctivitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
CLEC7A (Dectin-1) signaling 66
Show member pathways
 11.84 MUC5AC MUC3A FCER1G
2
IL4-mediated signaling events 61
11.18 IL4 CCL11
3
Eicosanoid ligand-binding receptors 66
Show member pathways
 11.05 CYSLTR2 CYSLTR1
4
Th2 Differentiation 65
10.98 IL4 CCL11
5
Termination of O-glycan biosynthesis 66
Show member pathways
 10.97 MUC5AC MUC3A FCER1G
6
Lung fibrosis 74
10.72 IL4 CYSLTR2 CMA1 CCL11
7
Endothelins 61
10.66 CYSLTR2 CYSLTR1
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GO Terms for Vernal Conjunctivitis

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Biological processes related to Vernal Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 leukotriene signaling pathway GO:0061737 8.92 CYSLTR2 CYSLTR1

Molecular functions related to Vernal Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 leukotriene receptor activity GO:0004974 9.26 CYSLTR2 CYSLTR1
2 cysteinyl leukotriene receptor activity GO:0001631 8.92 CYSLTR1 CYSLTR2
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Sources for Vernal Conjunctivitis

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2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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