MCID: VRN004
MIFTS: 55

Vernal Keratoconjunctivitis

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Vernal Keratoconjunctivitis

MalaCards integrated aliases for Vernal Keratoconjunctivitis:

Name: Vernal Keratoconjunctivitis 54 60
Keratoconjunctivitis, Vernal 74
Keratoconjunctivitis Vernal 56
Spring Catarrh 60
Vkc 54

Characteristics:

Orphanet epidemiological data:

60
vernal keratoconjunctivitis
Inheritance: Not applicable; Age of onset: Childhood; Age of death: normal life expectancy;

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 60  
Rare eye diseases


External Ids:

ICD10 via Orphanet 35 H16.2
UMLS via Orphanet 75 C0022577
Orphanet 60 ORPHA70476
UMLS 74 C0022577

Summaries for Vernal Keratoconjunctivitis

NIH Rare Diseases : 54 Vernal keratoconjunctivitis (VKC) is a chronic, severe allergy that affects the surfaces of the eyes. It most commonly occurs in boys living in warm, dry climates. Attacks associated with VKC are common in the spring (hence the name "vernal") and summer but often reoccur in the winter. Signs and symptoms usually begin before 10 years of age and may include hard, cobblestone-like bumps (papillae) on the upper eyelid; sensitivity to light; redness; sticky mucus discharge; and involuntary blinking or spasms of the eyelid (blepharospasm). The condition usually subsides at the onset of puberty. It is caused by a hypersensitivity (allergic reaction) to airborne-allergens. Management focuses on preventing "flare ups" and relieving the symptoms of the condition.

MalaCards based summary : Vernal Keratoconjunctivitis, also known as keratoconjunctivitis, vernal, is related to keratoconjunctivitis and papillary conjunctivitis. An important gene associated with Vernal Keratoconjunctivitis is RNASE3 (Ribonuclease A Family Member 3), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Tacrolimus and Loteprednol have been mentioned in the context of this disorder. Affiliated tissues include eye, thyroid and skin, and related phenotypes are photophobia and pruritus

Wikipedia : 77 Vernal keratoconjunctivitis (VKC) or spring catarrh is a recurrent, bilateral, and self-limiting... more...

Related Diseases for Vernal Keratoconjunctivitis

Diseases related to Vernal Keratoconjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 173)
# Related Disease Score Top Affiliating Genes
1 keratoconjunctivitis 30.9 CCL11 ICAM1 IL13 IL4 IL5 RNASE3
2 papillary conjunctivitis 30.8 CCL11 IL4
3 atopic keratoconjunctivitis 30.7 IL4 IL5 RNASE3
4 giant papillary conjunctivitis 30.6 CCL11 IL4 RNASE3
5 vernal conjunctivitis 30.4 IL4 RNASE3
6 ige responsiveness, atopic 30.0 IL13 IL4 IL5 RNASE3
7 uveitis 30.0 CXCR3 ICAM1 IL4
8 conjunctivitis 29.7 CCL11 ICAM1 IL13 IL4 IL5 RNASE3
9 allergic conjunctivitis 29.6 CCL11 ICAM1 IL13 IL4 IL5 RNASE3
10 dermatitis 29.6 CCL11 IL13 IL4 IL5
11 hypereosinophilic syndrome 29.6 CCL11 IL13 IL4 IL5 RNASE3
12 allergic rhinitis 29.0 CCL11 ICAM1 IL13 IL4 IL5 RNASE3
13 allergic asthma 28.9 CCL11 CCL5 IL13 IL4 IL5 RNASE3
14 rhinitis 28.5 CCL11 CCL5 ICAM1 IL13 IL4 IL5
15 dermatitis, atopic 28.5 CCL11 CCL5 ICAM1 IL13 IL4 IL5
16 asthma 28.3 CCL11 CCL5 ICAM1 IL13 IL4 IL5
17 keratoconus 10.6
18 chlamydia 10.4
19 steroid-induced glaucoma 10.4
20 loeffler endocarditis 10.3 IL5 RNASE3
21 cow milk allergy 10.3 IL5 RNASE3
22 sinusitis 10.3 IL5 RNASE3
23 pemphigoid gestationis 10.3 CCL11 IL5
24 egg allergy 10.3 IL4 IL5
25 sulfamethoxazole allergy 10.3 IL4 IL5
26 keratitis, hereditary 10.3
27 limbal stem cell deficiency 10.3
28 trachoma 10.3
29 conjunctival pigmentation 10.3
30 fungal keratitis 10.3
31 trichinosis 10.3 IL4 IL5
32 gaucher disease, type ii 10.3 IL4 IL5
33 non-suppurative otitis media 10.3 IL4 IL5
34 wells syndrome 10.3 IL5 RNASE3
35 filarial elephantiasis 10.3 IL4 IL5
36 toxic oil syndrome 10.2 IL4 IL5
37 churg-strauss syndrome 10.2 IL5 RNASE3
38 maxillary sinusitis 10.2 CCL5 RNASE3
39 allergic bronchopulmonary aspergillosis 10.2 IL4 IL5
40 cellulitis 10.2 IL5 RNASE3
41 conjunctival nevus 10.2 MMP9 RNASE3
42 henoch-schoenlein purpura 10.2 ICAM1 RNASE3
43 diversion colitis 10.2 ICAM1 IL4
44 vulvovaginitis 10.2 CCL11 CCL5
45 collagenous colitis 10.2 MMP9 RNASE3
46 ocular cicatricial pemphigoid 10.2 IL4 RNASE3
47 bardet-biedl syndrome 15 10.2 ICAM1 IL4
48 poliomyelitis 10.2 ICAM1 IL4
49 blepharitis 10.2 CCL11 MMP9
50 inclusion conjunctivitis 10.2 CCL5 IL5

Graphical network of the top 20 diseases related to Vernal Keratoconjunctivitis:



Diseases related to Vernal Keratoconjunctivitis

Symptoms & Phenotypes for Vernal Keratoconjunctivitis

Human phenotypes related to Vernal Keratoconjunctivitis:

60 33 (show all 11)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 photophobia 60 33 hallmark (90%) Very frequent (99-80%) HP:0000613
2 pruritus 60 33 hallmark (90%) Very frequent (99-80%) HP:0000989
3 corneal neovascularization 60 33 hallmark (90%) Very frequent (99-80%) HP:0011496
4 lacrimation abnormality 60 33 hallmark (90%) Very frequent (99-80%) HP:0000632
5 abnormal conjunctiva morphology 60 33 hallmark (90%) Very frequent (99-80%) HP:0000502
6 allergy 60 33 hallmark (90%) Very frequent (99-80%) HP:0012393
7 punctate keratitis 60 33 hallmark (90%) Very frequent (99-80%) HP:0011859
8 abnormal sclera morphology 33 hallmark (90%) HP:0000591
9 scarring 60 33 frequent (33%) Frequent (79-30%) HP:0100699
10 abnormality of the cornea 60 Very frequent (99-80%)
11 abnormality of the sclera 60 Very frequent (99-80%)

MGI Mouse Phenotypes related to Vernal Keratoconjunctivitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.76 CCL11 CCL5 CXCR3 ICAM1 IL13 IL4
2 digestive/alimentary MP:0005381 9.65 ICAM1 IL13 IL4 IL5 MMP9
3 immune system MP:0005387 9.56 CCL11 CCL5 CXCR3 ICAM1 IL13 IL4
4 respiratory system MP:0005388 9.1 CCL11 CXCR3 IL13 IL4 IL5 MMP9

Drugs & Therapeutics for Vernal Keratoconjunctivitis

Drugs for Vernal Keratoconjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 51)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 2 104987-11-3 6473866 445643 439492
2
Loteprednol Approved, Experimental Phase 4 82034-46-6, 129260-79-3 9865442 444025
3
Tobramycin Approved, Investigational Phase 4 32986-56-4 36294 5496
4
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
5
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 22916-47-8 4189
6
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
7
Histamine Approved, Investigational Phase 4,Phase 3 51-45-6 774
8
Glutamic Acid Approved, Nutraceutical Phase 4 56-86-0 33032
9 Ophthalmic Solutions Phase 4,Phase 3,Phase 2
10 Immunologic Factors Phase 4,Phase 3,Phase 2
11 Immunosuppressive Agents Phase 4,Phase 3,Phase 2
12 Calcineurin Inhibitors Phase 4,Phase 3,Phase 2
13 Anti-Infective Agents Phase 4,Phase 3,Phase 2
14 Anti-Allergic Agents Phase 4,Phase 3
15 Anti-Bacterial Agents Phase 4
16 Antineoplastic Agents, Hormonal Phase 4
17 HIV Protease Inhibitors Phase 4
18
protease inhibitors Phase 4
19 Dermatologic Agents Phase 4,Phase 3,Phase 2
20 BB 1101 Phase 4
21 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
22 Antifungal Agents Phase 4,Phase 3,Phase 2
23 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2
24 Hormone Antagonists Phase 4
25 Hormones Phase 4
26 Antiemetics Phase 4
27 Gastrointestinal Agents Phase 4
28 glucocorticoids Phase 4
29 Autonomic Agents Phase 4
30 Antirheumatic Agents Phase 4,Phase 3,Phase 2
31 Peripheral Nervous System Agents Phase 4
32 Anti-Inflammatory Agents Phase 4
33 Cyclosporins Phase 4,Phase 3,Phase 2
34 Histamine Antagonists Phase 4,Phase 3
35 Neurotransmitter Agents Phase 4,Phase 3
36 Bronchodilator Agents Phase 4
37 Respiratory System Agents Phase 4
38
Histamine Phosphate Phase 4,Phase 3 51-74-1 65513
39 Histamine H1 Antagonists Phase 4,Phase 3
40 Protective Agents Phase 4
41 Anti-Asthmatic Agents Phase 4
42 Isospaglumic acid Phase 4
43 Neuroprotective Agents Phase 4
44
Ketotifen Approved Phase 3 34580-14-8, 34580-13-7 3827
45 Antipruritics Phase 3
46 Acidophilus Phase 2, Phase 3
47 Antibodies Phase 1
48 Immunoglobulin G Phase 1
49 Immunoglobulins Phase 1
50 Antibodies, Monoclonal Phase 1

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 Topical Tacrolimus in Vernal Keratoconjunctivitis Unknown status NCT02456025 Phase 4 Topical tacrolimus
2 A Novel Combined Therapy for Refractory Vernal Keratoconjunctivitis Completed NCT03464435 Phase 4 Tacrolimus
3 Topical Cyclosporine for Vernal Keratoconjunctivitis (VKC) in Rwanda Completed NCT01211327 Phase 4 Cyclosporine A;Dexamethasone
4 Study of the Clinical and Biological Efficacity of NAAXIA SINE® in Vernal Keratoconjunctivitis Completed NCT00357019 Phase 4 N-acetyl-aspartyl-glutamate (NAAXIA Sine)
5 Double-Masked Trial of NOVA22007 (1mg/mL Ciclosporin/Cyclosporine) Versus Vehicle in Pediatric Patients With Active Severe Vernal Keratoconjunctivitis Completed NCT01751126 Phase 3 NOVA22007 ''Ciclosporin'';Placebo
6 Cyclosporin A Eye Drop Treatment in Vernal Keratoconjunctivitis Completed NCT00426023 Phase 3 Cyclosporine A 0,05% eye drop;ketotifen fumarate 0.025% eye drops
7 Lactobacillus Rhamnosus GG Oral Treatment Efficacy on Vernal Keratoconjunctivitis Treatment Completed NCT00445120 Phase 2, Phase 3 Lactobacillus Rhamnosus GG;placebo (sugar)
8 Phase III Study of 0.1% Tacrolimus(FK506) Ophthalmic Suspension in Patients With Vernal Keratoconjunctivitis Completed NCT00567762 Phase 3 FK506;placebo
9 Efficacy and Tolerance of Nova22007 Versus Vehicle in Patients With Vernal Keratoconjunctivitis (VKC) Completed NCT00328653 Phase 2, Phase 3 cyclosporine
10 Phase III, Long-Term, Open-Label, Extension Study of 0.1% Tacrolimus(FK506) Ophthalmic Suspension in Patients With Vernal Keratoconjunctivitis Completed NCT00567918 Phase 3 FK506
11 Efficacy Study of FK-506 and Cyclosporine in Vernal Keratoconjunctivits (VKC) Completed NCT01068054 Phase 2, Phase 3 tacrolimus;cyclosporins
12 A Study of AK002 in Patients With Atopic Keratoconjunctivitis, Vernal Keratoconjunctivitis, and Perennial Allergic Conjunctivitis Active, not recruiting NCT03379311 Phase 1 AK002
13 Cytokine Assay in Tears of Healthy Children and With Vernal Keratoconjunctivitis: Case Control Study and Monitoring of Cases at 6 Months Unknown status NCT02057822
14 Dermatologic Tacrolimus Ointment on Eyelids in the Treatment of Refractory Vernal Keratoconjunctivitis and Atopic Keratoconjunctivitis Recruiting NCT03557203
15 China Red Eye Study on Allergic Conjunctivitis Active, not recruiting NCT03812952

Search NIH Clinical Center for Vernal Keratoconjunctivitis

Genetic Tests for Vernal Keratoconjunctivitis

Anatomical Context for Vernal Keratoconjunctivitis

MalaCards organs/tissues related to Vernal Keratoconjunctivitis:

42
Eye, Thyroid, Skin, Testes, Endothelial, Neutrophil, T Cells

Publications for Vernal Keratoconjunctivitis

Articles related to Vernal Keratoconjunctivitis:

(show top 50) (show all 354)
# Title Authors Year
1
Omalizumab as single-dose therapy for vernal keratoconjunctivitis. ( 30243989 )
2019
2
A Randomized, Controlled Trial of Cyclosporine A Cationic Emulsion in Pediatric Vernal Keratoconjunctivitis: The VEKTIS Study. ( 30593775 )
2019
3
Thymic Stromal Lymphopoietin-Related Allergic Pathway in Patients With Vernal Keratoconjunctivitis. ( 30601284 )
2019
4
Monotherapy of topical tacrolimus 0.03% in the treatment of vernal keratoconjunctivitis in the pediatric population. ( 30664932 )
2019
5
Therapeutic effects of Houttuynia eye drops combined with olopatadine hydrochloride eye drops on vernal keratoconjunctivitis. ( 30679995 )
2019
6
Long-term use of topical tacrolimus ointment: a safe and effective option for the treatment of vernal keratoconjunctivitis. ( 30698232 )
2019
7
Vitamin D serum levels in children with vernal keratoconjunctivitis and disease control. ( 30843446 )
2019
8
Dermatologic tacrolimus ointment on the eyelids for steroid-refractory vernal keratoconjunctivitis. ( 30852635 )
2019
9
Prevalence of vernal keratoconjunctivitis and its associated factors among children in Gambella town, southwest Ethiopia, June 2018. ( 30998721 )
2019
10
Steroid-induced glaucoma and blindness in vernal keratoconjunctivitis. ( 31055451 )
2019
11
Increased Lacrimal Fluid Level of HMGB1 in Vernal Keratoconjunctivitis. ( 29847189 )
2018
12
Vernal keratoconjunctivitis in human immunodeficiency virus - The possible role of T-helper 1-T-helper 2 shift. ( 29941754 )
2018
13
Vascular Endothelial Growth Factor (VEGF) Serological and Lacrimal Signaling in Patients Affected by Vernal Keratoconjunctivitis (VKC). ( 30305958 )
2018
14
Tacrolimus as an Effective and Safe Therapeutic Alternative in Vernal Keratoconjunctivitis Resistant to Conventional Treatment. ( 30350791 )
2018
15
Tear Ferning Test and Pathological Effects on Ocular Surface before and after Topical Cyclosporine in Vernal Keratoconjunctivitis Patients. ( 30405906 )
2018
16
Vernal Keratoconjunctivitis. ( 30550738 )
2018
17
Oral cyclosporine for severe vernal keratoconjunctivitis in children. ( 30551992 )
2018
18
Vernal Keratoconjunctivitis-When Medication Fails. ( 30581132 )
2018
19
Serum Vitamin D Levels in Children with Vernal Keratoconjunctivitis. ( 27775457 )
2018
20
Therapeutic Effect of 0.1% Tacrolimus Eye Drops in the Tarsal Form of Vernal Keratoconjunctivitis. ( 28803239 )
2018
21
Comparative Evaluation of Tacrolimus Versus Interferon Alpha-2b Eye Drops in the Treatment of Vernal Keratoconjunctivitis: A Randomized, Double-Masked Study. ( 29040120 )
2018
22
Outcomes and Rationale of Excision and Mucous Membrane Grafting in Palpebral Vernal Keratoconjunctivitis. ( 29040121 )
2018
23
Corneal backward scattering and higher-order aberrations in children with vernal keratoconjunctivitis and normal topography. ( 29090512 )
2018
24
Quality of life and clinical characterization of patients with vernal keratoconjunctivitis in a pediatric population in Colombia. ( 29338965 )
2018
25
Corneal staining patterns in vernal keratoconjunctivitis: the new VKC-CLEK scoring scale. ( 29367201 )
2018
26
Vernal keratoconjunctivitis. ( 29391772 )
2018
27
Assessment of Drug Usage Pattern in Patients Treated for Vernal Keratoconjunctivitis Attending a Tertiary Eye Care Centre in Eastern India: A Cross-Sectional Study. ( 31056577 )
2018
28
Impact of Vernal Keratoconjunctivitis on School Children in Egypt. ( 27128625 )
2017
29
The Study of Interleukin-17 Level in Vernal Keratoconjunctivitis Disease and its Relationship between Symptom and Sign Severity. ( 27420560 )
2017
30
Vitamin D levels in children affected by vernal keratoconjunctivitis. ( 27786545 )
2017
31
Omalizumab in Severe Refractory Vernal Keratoconjunctivitis in Children: Case Series and Review of the Literature. ( 27909980 )
2017
32
Comparative Evaluation of Tacrolimus Versus Interferon Alpha-2b Eye Drops in the Treatment of Vernal Keratoconjunctivitis: A Randomized, Double-Masked Study. ( 28399035 )
2017
33
Vernal keratoconjunctivitis treated with omalizumab: A case series. ( 28543949 )
2017
34
Kingella kingae Keratitis in a Child with Underlying Vernal Keratoconjunctivitis. ( 28546880 )
2017
35
Corneal Complications And Visual Impairment In Vernal Keratoconjunctivitis Patients. ( 28712175 )
2017
36
Tacrolimus eye drops as monotherapy for vernal keratoconjunctivitis: a randomized controlled trial. ( 28832739 )
2017
37
Supratarsal injection of triamcinolone for severe vernal keratoconjunctivitis in children. ( 28832741 )
2017
38
Long-term use of 0.003% tacrolimus suspension for treatment of vernal keratoconjunctivitis. ( 29118487 )
2017
39
Sequential Keraring implantation and corneal cross-linking for the treatment of keratoconus in children with vernal keratoconjunctivitis. ( 29123375 )
2017
40
Clinical Usefulness of Monitoring Expression Levels of CCL24 (Eotaxin-2) mRNA on the Ocular Surface in Patients with Vernal Keratoconjunctivitis and Atopic Keratoconjunctivitis. ( 27721987 )
2016
41
Quiescent and Active Tear Protein Profiles to Predict Vernal Keratoconjunctivitis Reactivation. ( 26989694 )
2016
42
New Finding in Vernal Keratoconjunctivitis: Splendore-Hoeppli Phenomenon. ( 27027918 )
2016
43
Systematic approach to managing vernal keratoconjunctivitis in clinical practice: Severity grading system and a treatment algorithm. ( 27050351 )
2016
44
Efficacy and safety of low-dose topical tacrolimus in vernal keratoconjunctivitis. ( 27103784 )
2016
45
Tacrolimus in Corticosteroid-Refractory Vernal Keratoconjunctivitis. ( 27310883 )
2016
46
Vitiligo in association with vernal keratoconjunctivitis. ( 27330391 )
2016
47
An Update on the Therapeutic Approach to Vernal Keratoconjunctivitis. ( 27461427 )
2016
48
Very Low Prevalence of Keratoconus in a Large Series of Vernal Keratoconjunctivitis Patients. ( 27640005 )
2016
49
Prevalence and associated factors of vernal keratoconjunctivitis among children in Gondar city, Northwest Ethiopia. ( 27681885 )
2016
50
Vernal keratoconjunctivitis: culmination of management using immunosuppression, surgical and prosthetic therapy over quarter century. ( 27881591 )
2016

Variations for Vernal Keratoconjunctivitis

Expression for Vernal Keratoconjunctivitis

Search GEO for disease gene expression data for Vernal Keratoconjunctivitis.

Pathways for Vernal Keratoconjunctivitis

Pathways related to Vernal Keratoconjunctivitis according to GeneCards Suite gene sharing:

(show all 40)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.79 CCL11 CCL5 ICAM1 IL13 IL4 IL5
2
Show member pathways
13.63 CCL11 CCL5 CXCR3 IL13 IL4 IL5
3
Show member pathways
13.46 CCL11 CCL5 CXCR3 IL13 IL4 IL5
4
Show member pathways
13.33 CCL11 CCL5 ICAM1 IL13 IL4 IL5
5
Show member pathways
13.22 CCL11 CCL5 CXCR3 IL13 IL4 IL5
6
Show member pathways
13.19 CCL11 CCL5 CXCR3 ICAM1 MMP9
7
Show member pathways
13.16 CCL11 CCL5 ICAM1 IL13 IL4 IL5
8
Show member pathways
13.12 CCL11 CCL5 CXCR3 IL13 IL4 IL5
9
Show member pathways
12.71 CCL11 ICAM1 IL13 IL4 IL5 RNASE3
10 12.66 IL13 IL4 IL5 MMP9
11
Show member pathways
12.22 IL13 IL4 IL5
12
Show member pathways
12.18 CCL11 CCL5 ICAM1
13
Show member pathways
12.16 CCL5 ICAM1 IL4
14
Show member pathways
12.16 CCL11 IL13 IL4 IL5 MMP9
15
Show member pathways
12.07 CCL11 CCL5 CXCR3 ICAM1 MMP9
16
Show member pathways
11.9 IL13 IL4 MMP9
17 11.88 ICAM1 IL4 MMP9
18
Show member pathways
11.86 CCL11 CCL5 CXCR3
19 11.82 CCL5 ICAM1 MMP9
20
Show member pathways
11.75 CCL11 CCL5 ICAM1 IL13 IL4 IL5
21 11.69 ICAM1 IL13 IL4 IL5
22 11.66 CXCR3 IL13 IL4 IL5
23 11.61 CCL11 ICAM1 IL13 IL4 MMP9
24 11.56 CCL11 IL4 IL5
25 11.36 ICAM1 MMP9
26 11.36 CCL5 ICAM1 IL13 IL4
27 11.29 CCL11 IL13 IL4 IL5
28 11.26 CCL5 MMP9
29 11.23 IL13 IL4 IL5
30 11.2 CCL11 CXCR3
31 11.2 CCL11 CCL5 IL13 IL4 MMP9
32 11.18 IL4 IL5
33 11.17 IL13 IL4 IL5
34 11.15 CCL5 MMP9
35 11.12 IL13 IL4 IL5
36 11.04 ICAM1 MMP9
37 11.03 CCL11 CCL5 IL13 IL4 IL5
38 10.9 CCL11 CCL5 IL13 IL4 IL5 MMP9
39 10.86 CCL5 MMP9
40 10.86 CCL11 CCL5 IL13 IL4 IL5

GO Terms for Vernal Keratoconjunctivitis

Cellular components related to Vernal Keratoconjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 CCL11 CCL5 IL13 IL4 IL5 MMP9
2 extracellular space GO:0005615 9.23 CCL11 CCL5 ICAM1 IL13 IL4 IL5

Biological processes related to Vernal Keratoconjunctivitis according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.76 CCL11 CCL5 ICAM1
2 positive regulation of cell migration GO:0030335 9.74 CCL11 CCL5 MMP9
3 chemotaxis GO:0006935 9.7 CCL11 CCL5 CXCR3
4 cellular response to tumor necrosis factor GO:0071356 9.69 CCL11 CCL5 ICAM1
5 cellular response to interferon-gamma GO:0071346 9.67 CCL11 CCL5 ICAM1
6 cellular response to interleukin-1 GO:0071347 9.65 CCL11 CCL5 ICAM1
7 regulation of signaling receptor activity GO:0010469 9.65 CCL11 CCL5 IL13 IL4 IL5
8 chemokine-mediated signaling pathway GO:0070098 9.63 CCL11 CCL5 CXCR3
9 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.61 CCL5 IL13 IL4
10 monocyte chemotaxis GO:0002548 9.59 CCL11 CCL5
11 lymphocyte chemotaxis GO:0048247 9.58 CCL11 CCL5
12 leukocyte cell-cell adhesion GO:0007159 9.56 CCL5 ICAM1
13 positive regulation of JAK-STAT cascade GO:0046427 9.55 CCL5 IL5
14 inflammatory response GO:0006954 9.55 CCL11 CCL5 CXCR3 IL13 IL5
15 eosinophil chemotaxis GO:0048245 9.54 CCL11 CCL5
16 positive regulation of B cell proliferation GO:0030890 9.54 IL13 IL4 IL5
17 negative regulation of endothelial cell apoptotic process GO:2000352 9.5 ICAM1 IL13 IL4
18 immune response GO:0006955 9.43 CCL11 CCL5 CXCR3 IL13 IL4 IL5
19 negative regulation of complement-dependent cytotoxicity GO:1903660 9.4 IL13 IL4
20 cytokine-mediated signaling pathway GO:0019221 9.17 CCL11 CCL5 ICAM1 IL13 IL4 IL5

Molecular functions related to Vernal Keratoconjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 9.26 CCL11 CCL5
2 CCR chemokine receptor binding GO:0048020 9.16 CCL11 CCL5
3 cytokine activity GO:0005125 9.02 CCL11 CCL5 IL13 IL4 IL5
4 cytokine receptor binding GO:0005126 8.96 IL13 IL4

Sources for Vernal Keratoconjunctivitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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