MCID: VRN004
MIFTS: 55

Vernal Keratoconjunctivitis

Categories: Rare diseases, Eye diseases

Aliases & Classifications for Vernal Keratoconjunctivitis

MalaCards integrated aliases for Vernal Keratoconjunctivitis:

Name: Vernal Keratoconjunctivitis 53 59
Keratoconjunctivitis, Vernal 73
Keratoconjunctivitis Vernal 55
Spring Catarrh 59
Vkc 53

Characteristics:

Orphanet epidemiological data:

59
vernal keratoconjunctivitis
Inheritance: Not applicable; Age of onset: Childhood; Age of death: normal life expectancy;

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 59  
Rare eye diseases


External Ids:

Orphanet 59 ORPHA70476
UMLS via Orphanet 74 C0022577
ICD10 via Orphanet 34 H16.2
UMLS 73 C0022577

Summaries for Vernal Keratoconjunctivitis

NIH Rare Diseases : 53 Vernal keratoconjunctivitis (VKC) is a chronic, severe allergy that affects the surfaces of the eyes. It most commonly occurs in boys living in warm, dry climates. Attacks associated with VKC are common in the spring (hence the name "vernal") and summer but often reoccur in the winter. Signs and symptoms usually begin before 10 years of age and may include hard, cobblestone-like bumps (papillae) on the upper eyelid; sensitivity to light; redness; sticky mucus discharge; and involuntary blinking or spasms of the eyelid (blepharospasm). The condition usually subsides at the onset of puberty. It is caused by a hypersensitivity (allergic reaction) to airborne-allergens. Management focuses on preventing "flare ups" and relieving the symptoms of the condition.

MalaCards based summary : Vernal Keratoconjunctivitis, also known as keratoconjunctivitis, vernal, is related to papillary conjunctivitis and atopic keratoconjunctivitis. An important gene associated with Vernal Keratoconjunctivitis is RNASE3 (Ribonuclease A Family Member 3), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Tacrolimus and Ephedrine have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and neutrophil, and related phenotypes are photophobia and lacrimation abnormality

Wikipedia : 76 Vernal keratoconjunctivitis (VKC) or spring catarrh is a recurrent, bilateral, and self-limiting... more...

Related Diseases for Vernal Keratoconjunctivitis

Diseases related to Vernal Keratoconjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 173)
# Related Disease Score Top Affiliating Genes
1 papillary conjunctivitis 30.9 CCL11 IL4
2 atopic keratoconjunctivitis 30.7 IL4 IL5 RNASE3
3 giant papillary conjunctivitis 30.5 CCL11 IL4 RNASE3
4 uveitis 29.5 CXCR3 ICAM1 IL4
5 keratoconjunctivitis 29.3 CCL11 ICAM1 IL13 IL4 IL5 RNASE3
6 conjunctivitis 28.2 CCL11 ICAM1 IL13 IL4 IL5 RNASE3
7 dermatitis 28.2 CCL11 IL13 IL4 IL5 RNASE3
8 allergic conjunctivitis 28.1 CCL11 ICAM1 IL13 IL4 IL5 RNASE3
9 allergic rhinitis 27.4 CCL11 ICAM1 IL13 IL4 IL5 RNASE3
10 allergic asthma 27.3 CCL11 CCL5 IL13 IL4 IL5 RNASE3
11 rhinitis 26.5 CCL11 CCL5 ICAM1 IL13 IL4 IL5
12 asthma 25.8 CCL11 CCL5 ICAM1 IL13 IL4 IL5
13 dermatitis, atopic 25.4 CCL11 CCL5 CXCR3 ICAM1 IL13 IL4
14 loeffler endocarditis 10.7 IL5 RNASE3
15 cow milk allergy 10.7 IL5 RNASE3
16 pemphigoid gestationis 10.6 CCL11 IL5
17 cellulitis 10.6 IL5 RNASE3
18 sinusitis 10.6 IL5 RNASE3
19 egg allergy 10.6 IL4 IL5
20 trichinosis 10.6 IL4 IL5
21 non-suppurative otitis media 10.5 IL4 IL5
22 cercarial dermatitis 10.5 IL4 IL5
23 toxic oil syndrome 10.5 IL4 IL5
24 wells syndrome 10.5 IL5 RNASE3
25 primary amebic meningoencephalitis 10.5 IL4 IL5
26 churg-strauss syndrome 10.5 IL5 RNASE3
27 henoch-schoenlein purpura 10.5 ICAM1 RNASE3
28 maxillary sinusitis 10.5 CCL5 RNASE3
29 allergic bronchopulmonary aspergillosis 10.5 IL4 IL5
30 diversion colitis 10.5 ICAM1 IL4
31 conjunctival nevus 10.4 MMP9 RNASE3
32 keratoconus 10.4
33 vulvovaginitis 10.4 CCL11 CCL5
34 poliomyelitis 10.4 ICAM1 IL4
35 bardet-biedl syndrome 15 10.4 ICAM1 IL4
36 ocular cicatricial pemphigoid 10.4 IL4 RNASE3
37 eosinophilic gastroenteritis 10.3 CCL11 IL5 RNASE3
38 vernal conjunctivitis 10.3 IL4 RNASE3
39 cough variant asthma 10.3 IL4 IL5 RNASE3
40 intrinsic asthma 10.3 IL4 IL5 RNASE3
41 bronchitis 10.3 CCL11 IL5 RNASE3
42 bullous pemphigoid 10.3 CCL11 IL5 RNASE3
43 genital herpes 10.3 CCL5 IL4
44 milk allergy 10.3 IL4 IL5 RNASE3
45 yellow fever 10.3 CCL5 IL5
46 blepharoconjunctivitis 10.3 CCL11 IL4 RNASE3
47 dermatitis herpetiformis 10.2 CCL11 IL4
48 paracoccidioidomycosis 10.2 IL4 IL5
49 pustulosis palmaris et plantaris 10.2 CXCR3 IL5
50 cytomegalovirus infection 10.2 CCL5 ICAM1

Graphical network of the top 20 diseases related to Vernal Keratoconjunctivitis:



Diseases related to Vernal Keratoconjunctivitis

Symptoms & Phenotypes for Vernal Keratoconjunctivitis

Human phenotypes related to Vernal Keratoconjunctivitis:

59 32 (show all 12)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 photophobia 59 32 hallmark (90%) Very frequent (99-80%) HP:0000613
2 lacrimation abnormality 59 32 hallmark (90%) Very frequent (99-80%) HP:0000632
3 pruritus 59 32 hallmark (90%) Very frequent (99-80%) HP:0000989
4 corneal neovascularization 59 32 hallmark (90%) Very frequent (99-80%) HP:0011496
5 punctate keratitis 59 32 hallmark (90%) Very frequent (99-80%) HP:0011859
6 allergy 59 32 hallmark (90%) Very frequent (99-80%) HP:0012393
7 scarring 59 32 frequent (33%) Frequent (79-30%) HP:0100699
8 abnormality of the cornea 59 Very frequent (99-80%)
9 abnormality of the conjunctiva 59 Very frequent (99-80%)
10 abnormality of the sclera 59 Very frequent (99-80%)
11 abnormal conjunctiva morphology 32 hallmark (90%) HP:0000502
12 abnormal sclera morphology 32 hallmark (90%) HP:0000591

MGI Mouse Phenotypes related to Vernal Keratoconjunctivitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.76 CCL11 CCL5 CXCR3 ICAM1 IL13 IL4
2 digestive/alimentary MP:0005381 9.65 ICAM1 IL13 IL4 IL5 MMP9
3 immune system MP:0005387 9.56 ICAM1 IL13 IL4 IL5 MMP9 CCL11
4 respiratory system MP:0005388 9.1 CCL11 CXCR3 IL13 IL4 IL5 MMP9

Drugs & Therapeutics for Vernal Keratoconjunctivitis

Drugs for Vernal Keratoconjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 51)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 2 104987-11-3 445643 439492
2
Ephedrine Approved Phase 4,Phase 3,Phase 2 299-42-3 9294
3
Pseudoephedrine Approved Phase 4,Phase 3,Phase 2 90-82-4 7028
4
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 22916-47-8 4189
5
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
6
Histamine Approved, Investigational Phase 4,Phase 3 75614-87-8, 51-45-6 774
7
Glutamic Acid Approved, Nutraceutical Phase 4 56-86-0 33032
8 Tetrahydrozoline Phase 4,Phase 3,Phase 2
9 Ophthalmic Solutions Phase 4,Phase 3,Phase 2
10 Immunosuppressive Agents Phase 4,Phase 3,Phase 2
11 Calcineurin Inhibitors Phase 4,Phase 3,Phase 2
12
Histamine Phosphate Phase 4,Phase 3 51-74-1 65513
13 Dexamethasone acetate Phase 4 1177-87-3
14 glucocorticoids Phase 4
15
protease inhibitors Phase 4
16 Respiratory System Agents Phase 4,Phase 3,Phase 2
17 N-acetyl-1-aspartylglutamic acid Phase 4
18 Gastrointestinal Agents Phase 4
19 Nasal Decongestants Phase 4,Phase 3,Phase 2
20 Neuroprotective Agents Phase 4
21 Neurotransmitter Agents Phase 4,Phase 3
22 Cyclosporins Phase 4,Phase 3,Phase 2
23 Histamine Antagonists Phase 4,Phase 3
24 Histamine H1 Antagonists Phase 4,Phase 3
25 HIV Protease Inhibitors Phase 4
26 Hormone Antagonists Phase 4
27 Dermatologic Agents Phase 4,Phase 3,Phase 2
28 Hormones Phase 4
29 Anti-Allergic Agents Phase 4,Phase 3
30 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
31 Vasoconstrictor Agents Phase 4,Phase 3,Phase 2
32 Anti-Asthmatic Agents Phase 4
33 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
34 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2
35 Anti-Infective Agents Phase 4,Phase 3,Phase 2
36 Antiemetics Phase 4
37 Antifungal Agents Phase 4,Phase 3,Phase 2
38 Protective Agents Phase 4
39 Anti-Inflammatory Agents Phase 4
40 Antirheumatic Agents Phase 4,Phase 3,Phase 2
41 BB 1101 Phase 4
42 Autonomic Agents Phase 4,Phase 3,Phase 2
43 Bronchodilator Agents Phase 4
44 Antineoplastic Agents, Hormonal Phase 4
45
Ketotifen Approved Phase 3 34580-14-8, 34580-13-7 3827
46 Antipruritics Phase 3
47 Acidophilus Nutraceutical Phase 2, Phase 3
48 Immunoglobulin G Phase 1
49 Antibodies Phase 1
50 Immunoglobulins Phase 1

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Topical Tacrolimus in Vernal Keratoconjunctivitis Unknown status NCT02456025 Phase 4 Topical tacrolimus
2 A Novel Combined Therapy for Refractory Vernal Keratoconjunctivitis Completed NCT03464435 Phase 4 Tacrolimus
3 Topical Cyclosporine for Vernal Keratoconjunctivitis (VKC) in Rwanda Completed NCT01211327 Phase 4 Cyclosporine A;Dexamethasone
4 Study of the Clinical and Biological Efficacity of NAAXIA SINE® in Vernal Keratoconjunctivitis Completed NCT00357019 Phase 4 N-acetyl-aspartyl-glutamate (NAAXIA Sine)
5 Double-Masked Trial of NOVA22007 (1mg/mL Ciclosporin/Cyclosporine) Versus Vehicle in Pediatric Patients With Active Severe Vernal Keratoconjunctivitis Completed NCT01751126 Phase 3 NOVA22007 ''Ciclosporin'';Placebo
6 Cyclosporin A Eye Drop Treatment in Vernal Keratoconjunctivitis Completed NCT00426023 Phase 3 Cyclosporine A 0,05% eye drop;ketotifen fumarate 0.025% eye drops
7 Lactobacillus Rhamnosus GG Oral Treatment Efficacy on Vernal Keratoconjunctivitis Treatment Completed NCT00445120 Phase 2, Phase 3 Lactobacillus Rhamnosus GG;placebo (sugar)
8 Phase III Study of 0.1% Tacrolimus(FK506) Ophthalmic Suspension in Patients With Vernal Keratoconjunctivitis Completed NCT00567762 Phase 3 FK506;placebo
9 Efficacy and Tolerance of Nova22007 Versus Vehicle in Patients With Vernal Keratoconjunctivitis (VKC) Completed NCT00328653 Phase 2, Phase 3 cyclosporine
10 Phase III, Long-Term, Open-Label, Extension Study of 0.1% Tacrolimus(FK506) Ophthalmic Suspension in Patients With Vernal Keratoconjunctivitis Completed NCT00567918 Phase 3 FK506
11 Efficacy Study of FK-506 and Cyclosporine in Vernal Keratoconjunctivits (VKC) Completed NCT01068054 Phase 2, Phase 3 tacrolimus;cyclosporins
12 A Study of AK002 in Patients With Atopic Keratoconjunctivitis, Vernal Keratoconjunctivitis, and Perennial Allergic Conjunctivitis Recruiting NCT03379311 Phase 1 AK002
13 Cytokine Assay in Tears of Healthy Children and With Vernal Keratoconjunctivitis: Case Control Study and Monitoring of Cases at 6 Months Unknown status NCT02057822
14 Dermatologic Tacrolimus Ointment on Eyelids in the Treatment of Refractory Vernal Keratoconjunctivitis and Atopic Keratoconjunctivitis Recruiting NCT03557203

Search NIH Clinical Center for Vernal Keratoconjunctivitis

Genetic Tests for Vernal Keratoconjunctivitis

Anatomical Context for Vernal Keratoconjunctivitis

MalaCards organs/tissues related to Vernal Keratoconjunctivitis:

41
Eye, Testes, Neutrophil, T Cells, Thyroid

Publications for Vernal Keratoconjunctivitis

Articles related to Vernal Keratoconjunctivitis:

(show top 50) (show all 334)
# Title Authors Year
1
Corneal staining patterns in vernal keratoconjunctivitis: the new VKC-CLEK scoring scale. ( 29367201 )
2018
2
Increased Lacrimal Fluid Level of HMGB1 in Vernal Keratoconjunctivitis. ( 29847189 )
2018
3
Vernal keratoconjunctivitis in human immunodeficiency virus - The possible role of T-helper 1-T-helper 2 shift. ( 29941754 )
2018
4
Vernal keratoconjunctivitis. ( 29391772 )
2018
5
Outcomes and Rationale of Excision and Mucous Membrane Grafting in Palpebral Vernal Keratoconjunctivitis. ( 29040121 )
2018
6
Comparative Evaluation of Tacrolimus Versus Interferon Alpha-2b Eye Drops in the Treatment of Vernal Keratoconjunctivitis: A Randomized, Double-Masked Study. ( 29040120 )
2018
7
Quality of life and clinical characterization of patients with vernal keratoconjunctivitis in a pediatric population in Colombia. ( 29338965 )
2018
8
Tacrolimus eye drops as monotherapy for vernal keratoconjunctivitis: a randomized controlled trial. ( 28832739 )
2017
9
Supratarsal injection of triamcinolone for severe vernal keratoconjunctivitis in children. ( 28832741 )
2017
10
Long-term use of 0.003% tacrolimus suspension for treatment of vernal keratoconjunctivitis. ( 29118487 )
2017
11
Comparative Evaluation of Tacrolimus Versus Interferon Alpha-2b Eye Drops in the Treatment of Vernal Keratoconjunctivitis: A Randomized, Double-Masked Study. ( 28399035 )
2017
12
Kingella kingae Keratitis in a Child with Underlying Vernal Keratoconjunctivitis. ( 28546880 )
2017
13
Therapeutic Effect of 0.1% Tacrolimus Eye Drops in the Tarsal Form of Vernal Keratoconjunctivitis. ( 28803239 )
2017
14
Corneal Complications And Visual Impairment In Vernal Keratoconjunctivitis Patients. ( 28712175 )
2017
15
Corneal backward scattering and higher-order aberrations in children with vernal keratoconjunctivitis and normal topography. ( 29090512 )
2017
16
Sequential Keraring implantation and corneal cross-linking for the treatment of keratoconus in children with vernal keratoconjunctivitis. ( 29123375 )
2017
17
Vitamin D levels in children affected by vernal keratoconjunctivitis. ( 27786545 )
2017
18
Vernal keratoconjunctivitis treated with omalizumab: A case series. ( 28543949 )
2017
19
Efficacy and safety of low-dose topical tacrolimus in vernal keratoconjunctivitis. ( 27103784 )
2016
20
Omalizumab in Severe Refractory Vernal Keratoconjunctivitis in Children: Case Series and Review of the Literature. ( 27909980 )
2016
21
The Study of Interleukin-17 Level in Vernal Keratoconjunctivitis Disease and its Relationship between Symptom and Sign Severity. ( 27420560 )
2016
22
An Update on the Therapeutic Approach to Vernal Keratoconjunctivitis. ( 27461427 )
2016
23
New Finding in Vernal Keratoconjunctivitis: Splendore-Hoeppli Phenomenon. ( 27027918 )
2016
24
Vernal keratoconjunctivitis: culmination of management using immunosuppression, surgical and prosthetic therapy over quarter century. ( 27881591 )
2016
25
Serum Vitamin D Levels in Children with Vernal Keratoconjunctivitis. ( 27775457 )
2016
26
Chaperone patterns in vernal keratoconjunctivitis are distinctive of cell and Hsp type and are modified by inflammatory stimuli. ( 26613380 )
2016
27
Vernal Keratoconjunctivitis in Kashmir: A temperate zone. ( 26961753 )
2016
28
Impact of Vernal Keratoconjunctivitis on School Children in Egypt. ( 27128625 )
2016
29
Quiescent and Active Tear Protein Profiles to Predict Vernal Keratoconjunctivitis Reactivation. ( 26989694 )
2016
30
Vitiligo in association with vernal keratoconjunctivitis. ( 27330391 )
2016
31
Prevalence and associated factors of vernal keratoconjunctivitis among children in Gondar city, Northwest Ethiopia. ( 27681885 )
2016
32
Clinical Usefulness of Monitoring Expression Levels of CCL24 (Eotaxin-2) mRNA on the Ocular Surface in Patients with Vernal Keratoconjunctivitis and Atopic Keratoconjunctivitis. ( 27721987 )
2016
33
Tacrolimus in Corticosteroid-Refractory Vernal Keratoconjunctivitis. ( 27310883 )
2016
34
Omalizumab Treatment of Vernal Keratoconjunctivitis. ( 26795360 )
2016
35
Very low prevalence of keratoconus in a large series of vernal keratoconjunctivitis patients. ( 27640005 )
2016
36
Tacrolimus Ointment for Treatment of Vernal Keratoconjunctivitis. ( 26957853 )
2016
37
Systematic approach to managing vernal keratoconjunctivitis in clinical practice: Severity grading system and a treatment algorithm. ( 27050351 )
2016
38
Is there is an association between the presence of Staphylococcus species and occurrence of vernal keratoconjunctivitis? ( 26586974 )
2015
39
Efficacy and safety of topical cyclosporine A 0.05% in vernal keratoconjunctivitis. ( 26768065 )
2015
40
Sex hormones in allergic conjunctivitis: altered levels of circulating androgens and estrogens in children and adolescents with vernal keratoconjunctivitis. ( 25756057 )
2015
41
A comprehensive review on vernal keratoconjunctivitis with emphasis on proteomics. ( 25744396 )
2015
42
In vivo confocal microscopy of meibomian glands and palpebral conjunctiva in vernal keratoconjunctivitis. ( 26044472 )
2015
43
Vernal Keratoconjunctivitis and immune-mediated diseases: One unique way to symptom control? ( 25692810 )
2015
44
Deep Anterior Lamellar Keratoplasty in Keratoconic Patients with versus without Vernal Keratoconjunctivitis. ( 26425311 )
2015
45
Dry Eye in Vernal Keratoconjunctivitis: A Cross-Sectional Comparative Study. ( 26496269 )
2015
46
Tacrolimus vs. cyclosporine eyedrops in severe cyclosporine-resistant vernal keratoconjunctivitis: A randomized, comparative, double-blind, crossover study. ( 25712437 )
2015
47
Microarray-based IgE detection in tears of patients with vernal keratoconjunctivitis. ( 26235361 )
2015
48
Corneal complications of vernal keratoconjunctivitis. ( 26258926 )
2015
49
Intracellular IL-4, IL-5, and IFN-I^ as the main characteristic of CD4+CD30+ T cells after allergen stimulation in patients with vernal keratoconjunctivitis. ( 25999672 )
2015
50
Topographic corneal changes in children with vernal keratoconjunctivitis: A report from Kathmandu, Nepal. ( 26070227 )
2015

Variations for Vernal Keratoconjunctivitis

Expression for Vernal Keratoconjunctivitis

Search GEO for disease gene expression data for Vernal Keratoconjunctivitis.

Pathways for Vernal Keratoconjunctivitis

Pathways related to Vernal Keratoconjunctivitis according to GeneCards Suite gene sharing:

(show all 36)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.76 CCL11 CCL5 ICAM1 IL13 IL4 IL5
2
Show member pathways
13.43 CCL11 CCL5 CXCR3 IL13 IL4 IL5
3
Show member pathways
13.29 CCL11 CCL5 IL13 IL4 IL5
4
Show member pathways
13.18 CCL11 CCL5 CXCR3 ICAM1 MMP9
5
Show member pathways
13.18 CCL11 CCL5 CXCR3 IL13 IL4 IL5
6
Show member pathways
13.13 CCL11 CCL5 ICAM1 IL13 IL4 IL5
7
Show member pathways
13.08 CCL11 CCL5 CXCR3 IL13 IL4 IL5
8
Show member pathways
12.67 CCL11 ICAM1 IL13 IL4 IL5 RNASE3
9 12.63 IL13 IL4 IL5 MMP9
10
Show member pathways
12.59 CCL5 ICAM1 IL13 IL4
11
Show member pathways
12.44 IL13 IL4 IL5
12
Show member pathways
12.26 IL13 IL4 IL5
13
Show member pathways
12.15 CCL11 CCL5 ICAM1
14
Show member pathways
12.14 CCL5 ICAM1 IL4
15
Show member pathways
12.1 CCL11 IL13 IL4 IL5 MMP9
16 11.85 ICAM1 IL4 MMP9
17
Show member pathways
11.82 CCL11 CCL5 CXCR3
18 11.79 CCL5 ICAM1 MMP9
19 11.65 ICAM1 IL13 IL4 IL5
20
Show member pathways
11.65 CCL11 CCL5 ICAM1 IL13 IL4 IL5
21 11.61 CXCR3 IL13 IL4 IL5
22 11.52 CCL11 IL4 IL5
23 11.41 CCL11 ICAM1 IL13 IL4 MMP9
24 11.35 ICAM1 MMP9
25 11.31 CCL5 ICAM1 IL13 IL4
26 11.25 CCL5 MMP9
27 11.22 CCL11 IL13 IL4 IL5
28 11.21 IL13 IL4 IL5
29 11.18 CCL11 CXCR3
30 11.16 IL4 IL5
31 11.16 IL13 IL4 IL5
32 11.13 CCL5 MMP9
33 11.09 IL13 IL4 IL5
34 11.02 ICAM1 MMP9
35 10.9 CCL11 CCL5 IL13 IL4 IL5 MMP9
36 10.83 CCL5 MMP9

GO Terms for Vernal Keratoconjunctivitis

Cellular components related to Vernal Keratoconjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 CCL11 CCL5 IL13 IL4 IL5 MMP9
2 external side of plasma membrane GO:0009897 9.33 CXCR3 ICAM1 IL13
3 extracellular space GO:0005615 9.23 CCL11 CCL5 ICAM1 IL13 IL4 IL5

Biological processes related to Vernal Keratoconjunctivitis according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.75 CCL11 CCL5 ICAM1
2 positive regulation of cell migration GO:0030335 9.73 CCL11 CCL5 MMP9
3 immune response GO:0006955 9.72 CCL11 CCL5 IL13 IL4 IL5
4 chemotaxis GO:0006935 9.69 CCL11 CCL5 CXCR3
5 cellular response to tumor necrosis factor GO:0071356 9.67 CCL11 CCL5 ICAM1
6 cellular response to interferon-gamma GO:0071346 9.65 CCL11 CCL5 ICAM1
7 cellular response to interleukin-1 GO:0071347 9.63 CCL11 CCL5 ICAM1
8 chemokine-mediated signaling pathway GO:0070098 9.61 CCL11 CCL5 CXCR3
9 monocyte chemotaxis GO:0002548 9.58 CCL11 CCL5
10 lymphocyte chemotaxis GO:0048247 9.57 CCL11 CCL5
11 leukocyte cell-cell adhesion GO:0007159 9.55 CCL5 ICAM1
12 regulation of signaling receptor activity GO:0010469 9.55 CCL11 CCL5 IL13 IL4 IL5
13 positive regulation of JAK-STAT cascade GO:0046427 9.54 CCL5 IL5
14 positive regulation of B cell proliferation GO:0030890 9.54 IL13 IL4 IL5
15 eosinophil chemotaxis GO:0048245 9.52 CCL11 CCL5
16 negative regulation of endothelial cell apoptotic process GO:2000352 9.43 ICAM1 IL13 IL4
17 negative regulation of complement-dependent cytotoxicity GO:1903660 9.4 IL13 IL4
18 inflammatory response GO:0006954 9.35 CCL11 CCL5 CXCR3 IL13 IL5
19 cytokine-mediated signaling pathway GO:0019221 9.17 CCL11 CCL5 ICAM1 IL13 IL4 IL5

Molecular functions related to Vernal Keratoconjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 CCR chemokine receptor binding GO:0048020 9.16 CCL11 CCL5
2 cytokine activity GO:0005125 9.02 CCL11 CCL5 IL13 IL4 IL5
3 cytokine receptor binding GO:0005126 8.96 IL13 IL4

Sources for Vernal Keratoconjunctivitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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