VKC
MCID: VRN004
MIFTS: 56

Vernal Keratoconjunctivitis (VKC)

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Vernal Keratoconjunctivitis

MalaCards integrated aliases for Vernal Keratoconjunctivitis:

Name: Vernal Keratoconjunctivitis 54 60
Keratoconjunctivitis, Vernal 74
Keratoconjunctivitis Vernal 56
Spring Catarrh 60
Vkc 54

Characteristics:

Orphanet epidemiological data:

60
vernal keratoconjunctivitis
Inheritance: Not applicable; Age of onset: Childhood; Age of death: normal life expectancy;

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 60  
Rare eye diseases


External Ids:

ICD10 via Orphanet 35 H16.2
UMLS via Orphanet 75 C0022577
Orphanet 60 ORPHA70476
UMLS 74 C0022577

Summaries for Vernal Keratoconjunctivitis

NIH Rare Diseases : 54 Vernal keratoconjunctivitis (VKC) is a chronic, severe allergy that affects the surfaces of the eyes. It most commonly occurs in boys living in warm, dry climates. Attacks associated with VKC are common in the spring (hence the name "vernal") and summer but often reoccur in the winter. Signs and symptoms usually begin before 10 years of age and may include hard, cobblestone-like bumps (papillae) on the upper eyelid; sensitivity to light; redness; sticky mucus discharge; and involuntary blinking or spasms of the eyelid (blepharospasm). The condition usually subsides at the onset of puberty. It is caused by a hypersensitivity (allergic reaction) to airborne-allergens. Management focuses on preventing "flare ups" and relieving the symptoms of the condition.

MalaCards based summary : Vernal Keratoconjunctivitis, also known as keratoconjunctivitis, vernal, is related to keratoconjunctivitis and atopic keratoconjunctivitis. An important gene associated with Vernal Keratoconjunctivitis is RNASE3 (Ribonuclease A Family Member 3), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Tacrolimus and Loteprednol have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and endothelial, and related phenotypes are photophobia and pruritus

Wikipedia : 77 Vernal keratoconjunctivitis (VKC) or spring catarrh is a recurrent, bilateral, and self-limiting... more...

Related Diseases for Vernal Keratoconjunctivitis

Diseases related to Vernal Keratoconjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 167)
# Related Disease Score Top Affiliating Genes
1 keratoconjunctivitis 30.9 CCL11 ICAM1 IL13 IL4 IL5 RNASE3
2 atopic keratoconjunctivitis 30.7 IL4 IL5 RNASE3
3 papillary conjunctivitis 30.6 CCL11 IL4
4 vernal conjunctivitis 30.4 IL4 RNASE3
5 giant papillary conjunctivitis 30.3 CCL11 IL4 RNASE3
6 uveitis 30.0 CXCR3 ICAM1 IL4
7 conjunctivitis 29.7 CCL11 ICAM1 IL13 IL4 IL5 RNASE3
8 allergic conjunctivitis 29.6 CCL11 ICAM1 IL13 IL4 IL5 RNASE3
9 dermatitis 29.6 CCL11 IL13 IL4 IL5
10 allergic rhinitis 29.0 CCL11 ICAM1 IL13 IL4 IL5 RNASE3
11 allergic asthma 28.9 CCL11 CCL5 IL13 IL4 IL5 RNASE3
12 rhinitis 28.5 CCL11 CCL5 ICAM1 IL13 IL4 IL5
13 dermatitis, atopic 28.5 CCL11 CCL5 ICAM1 IL13 IL4 IL5
14 asthma 28.3 CCL11 CCL5 ICAM1 IL13 IL4 IL5
15 keratoconus 10.6
16 chlamydia 10.4
17 loeffler endocarditis 10.3 IL5 RNASE3
18 cow milk allergy 10.3 IL5 RNASE3
19 sinusitis 10.3 IL5 RNASE3
20 pemphigoid gestationis 10.3 CCL11 IL5
21 limbal stem cell deficiency 10.3
22 trachoma 10.3
23 conjunctival pigmentation 10.3
24 steroid-induced glaucoma 10.3
25 egg allergy 10.3 IL4 IL5
26 sulfamethoxazole allergy 10.3 IL4 IL5
27 trichinosis 10.3 IL4 IL5
28 gaucher disease, type ii 10.3 IL4 IL5
29 non-suppurative otitis media 10.3 IL4 IL5
30 wells syndrome 10.2 IL5 RNASE3
31 filarial elephantiasis 10.2 IL4 IL5
32 toxic oil syndrome 10.2 IL4 IL5
33 churg-strauss syndrome 10.2 IL5 RNASE3
34 maxillary sinusitis 10.2 CCL5 RNASE3
35 allergic bronchopulmonary aspergillosis 10.2 IL4 IL5
36 cellulitis 10.2 IL5 RNASE3
37 conjunctival nevus 10.2 MMP9 RNASE3
38 henoch-schoenlein purpura 10.2 ICAM1 RNASE3
39 diversion colitis 10.2 ICAM1 IL4
40 vulvovaginitis 10.2 CCL11 CCL5
41 collagenous colitis 10.2 MMP9 RNASE3
42 ocular cicatricial pemphigoid 10.2 IL4 RNASE3
43 bardet-biedl syndrome 15 10.2 ICAM1 IL4
44 poliomyelitis 10.2 ICAM1 IL4
45 blepharitis 10.2 CCL11 MMP9
46 inclusion conjunctivitis 10.2 CCL5 IL5
47 eosinophilic gastroenteritis 10.1 CCL11 IL5 RNASE3
48 cough variant asthma 10.1 IL4 IL5 RNASE3
49 bronchitis 10.1 CCL11 IL5 RNASE3
50 intrinsic asthma 10.1 IL4 IL5 RNASE3

Graphical network of the top 20 diseases related to Vernal Keratoconjunctivitis:



Diseases related to Vernal Keratoconjunctivitis

Symptoms & Phenotypes for Vernal Keratoconjunctivitis

Human phenotypes related to Vernal Keratoconjunctivitis:

60 33 (show all 12)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 photophobia 60 33 hallmark (90%) Very frequent (99-80%) HP:0000613
2 pruritus 60 33 hallmark (90%) Very frequent (99-80%) HP:0000989
3 corneal neovascularization 60 33 hallmark (90%) Very frequent (99-80%) HP:0011496
4 lacrimation abnormality 60 33 hallmark (90%) Very frequent (99-80%) HP:0000632
5 allergy 60 33 hallmark (90%) Very frequent (99-80%) HP:0012393
6 punctate keratitis 60 33 hallmark (90%) Very frequent (99-80%) HP:0011859
7 abnormal conjunctiva morphology 33 hallmark (90%) HP:0000502
8 abnormal sclera morphology 33 hallmark (90%) HP:0000591
9 scarring 60 33 frequent (33%) Frequent (79-30%) HP:0100699
10 abnormality of the conjunctiva 60 Very frequent (99-80%)
11 abnormality of the cornea 60 Very frequent (99-80%)
12 abnormality of the sclera 60 Very frequent (99-80%)

MGI Mouse Phenotypes related to Vernal Keratoconjunctivitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.76 CCL11 CCL5 CXCR3 ICAM1 IL13 IL4
2 digestive/alimentary MP:0005381 9.65 ICAM1 IL13 IL4 IL5 MMP9
3 immune system MP:0005387 9.56 CCL11 CCL5 CXCR3 ICAM1 IL13 IL4
4 respiratory system MP:0005388 9.1 CCL11 CXCR3 IL13 IL4 IL5 MMP9

Drugs & Therapeutics for Vernal Keratoconjunctivitis

Drugs for Vernal Keratoconjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 51)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 2 104987-11-3 445643 439492 6473866
2
Loteprednol Approved, Experimental Phase 4 82034-46-6, 129260-79-3 444025 9865442
3
Tobramycin Approved, Investigational Phase 4 32986-56-4 5496 36294
4
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 22916-47-8 4189
5
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
6
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
7
Histamine Approved, Investigational Phase 4,Phase 3 51-45-6 774
8
Glutamic Acid Approved, Nutraceutical Phase 4 56-86-0 33032
9 Ophthalmic Solutions Phase 4,Phase 3,Phase 2
10 Immunosuppressive Agents Phase 4,Phase 3,Phase 2
11 Immunologic Factors Phase 4,Phase 3,Phase 2
12 Calcineurin Inhibitors Phase 4,Phase 3,Phase 2
13 Anti-Infective Agents Phase 4,Phase 3,Phase 2
14 Anti-Allergic Agents Phase 4,Phase 3
15 Anti-Bacterial Agents Phase 4
16 Anti-Inflammatory Agents Phase 4
17 HIV Protease Inhibitors Phase 4
18 Peripheral Nervous System Agents Phase 4
19 Autonomic Agents Phase 4
20 BB 1101 Phase 4
21 Hormones Phase 4
22
protease inhibitors Phase 4
23 Antineoplastic Agents, Hormonal Phase 4
24 Hormone Antagonists Phase 4
25 Antiemetics Phase 4
26 Cyclosporins Phase 4,Phase 3,Phase 2
27 Antifungal Agents Phase 4,Phase 3,Phase 2
28 Dermatologic Agents Phase 4,Phase 3,Phase 2
29 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
30 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2
31 glucocorticoids Phase 4
32 Antirheumatic Agents Phase 4,Phase 3,Phase 2
33 Gastrointestinal Agents Phase 4
34 Histamine Antagonists Phase 4,Phase 3
35 Protective Agents Phase 4
36 Neuroprotective Agents Phase 4
37 Bronchodilator Agents Phase 4
38 Respiratory System Agents Phase 4
39 Histamine H1 Antagonists Phase 4,Phase 3
40 Neurotransmitter Agents Phase 4,Phase 3
41 Isospaglumic acid Phase 4
42 Anti-Asthmatic Agents Phase 4
43
Histamine Phosphate Phase 4,Phase 3 51-74-1 65513
44
Ketotifen Approved Phase 3 34580-14-8, 34580-13-7 3827
45 Antipruritics Phase 3
46 Acidophilus Phase 2, Phase 3
47 Antibodies Phase 1
48 Antibodies, Monoclonal Phase 1
49 Immunoglobulin G Phase 1
50 Immunoglobulins Phase 1

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 Topical Tacrolimus in Vernal Keratoconjunctivitis Unknown status NCT02456025 Phase 4 Topical tacrolimus
2 A Novel Combined Therapy for Refractory Vernal Keratoconjunctivitis Completed NCT03464435 Phase 4 Tacrolimus
3 Topical Cyclosporine for Vernal Keratoconjunctivitis (VKC) in Rwanda Completed NCT01211327 Phase 4 Cyclosporine A;Dexamethasone
4 Study of the Clinical and Biological Efficacity of NAAXIA SINE® in Vernal Keratoconjunctivitis Completed NCT00357019 Phase 4 N-acetyl-aspartyl-glutamate (NAAXIA Sine)
5 Double-Masked Trial of NOVA22007 (1mg/mL Ciclosporin/Cyclosporine) Versus Vehicle in Pediatric Patients With Active Severe Vernal Keratoconjunctivitis Completed NCT01751126 Phase 3 NOVA22007 ''Ciclosporin'';Placebo
6 Cyclosporin A Eye Drop Treatment in Vernal Keratoconjunctivitis Completed NCT00426023 Phase 3 Cyclosporine A 0,05% eye drop;ketotifen fumarate 0.025% eye drops
7 Lactobacillus Rhamnosus GG Oral Treatment Efficacy on Vernal Keratoconjunctivitis Treatment Completed NCT00445120 Phase 2, Phase 3 Lactobacillus Rhamnosus GG;placebo (sugar)
8 Phase III Study of 0.1% Tacrolimus(FK506) Ophthalmic Suspension in Patients With Vernal Keratoconjunctivitis Completed NCT00567762 Phase 3 FK506;placebo
9 Efficacy and Tolerance of Nova22007 Versus Vehicle in Patients With Vernal Keratoconjunctivitis (VKC) Completed NCT00328653 Phase 2, Phase 3 cyclosporine
10 Phase III, Long-Term, Open-Label, Extension Study of 0.1% Tacrolimus(FK506) Ophthalmic Suspension in Patients With Vernal Keratoconjunctivitis Completed NCT00567918 Phase 3 FK506
11 Efficacy Study of FK-506 and Cyclosporine in Vernal Keratoconjunctivits (VKC) Completed NCT01068054 Phase 2, Phase 3 tacrolimus;cyclosporins
12 A Study of AK002 in Patients With Atopic Keratoconjunctivitis, Vernal Keratoconjunctivitis, and Perennial Allergic Conjunctivitis Active, not recruiting NCT03379311 Phase 1 AK002
13 Cytokine Assay in Tears of Healthy Children and With Vernal Keratoconjunctivitis: Case Control Study and Monitoring of Cases at 6 Months Unknown status NCT02057822
14 Dermatologic Tacrolimus Ointment on Eyelids in the Treatment of Refractory Vernal Keratoconjunctivitis and Atopic Keratoconjunctivitis Recruiting NCT03557203
15 China Red Eye Study on Allergic Conjunctivitis Active, not recruiting NCT03812952

Search NIH Clinical Center for Vernal Keratoconjunctivitis

Genetic Tests for Vernal Keratoconjunctivitis

Anatomical Context for Vernal Keratoconjunctivitis

MalaCards organs/tissues related to Vernal Keratoconjunctivitis:

42
Eye, Testes, Endothelial, Thyroid, Neutrophil, T Cells

Publications for Vernal Keratoconjunctivitis

Articles related to Vernal Keratoconjunctivitis:

(show top 50) (show all 348)
# Title Authors Year
1
Thymic Stromal Lymphopoietin-Related Allergic Pathway in Patients With Vernal Keratoconjunctivitis. ( 30601284 )
2019
2
Monotherapy of topical tacrolimus 0.03% in the treatment of vernal keratoconjunctivitis in the pediatric population. ( 30664932 )
2019
3
Therapeutic effects of Houttuynia eye drops combined with olopatadine hydrochloride eye drops on vernal keratoconjunctivitis. ( 30679995 )
2019
4
Long-term use of topical tacrolimus ointment: a safe and effective option for the treatment of vernal keratoconjunctivitis. ( 30698232 )
2019
5
Vitamin D serum levels in children with vernal keratoconjunctivitis and disease control. ( 30843446 )
2019
6
Dermatologic tacrolimus ointment on the eyelids for steroid-refractory vernal keratoconjunctivitis. ( 30852635 )
2019
7
Corneal staining patterns in vernal keratoconjunctivitis: the new VKC-CLEK scoring scale. ( 29367201 )
2018
8
Increased Lacrimal Fluid Level of HMGB1 in Vernal Keratoconjunctivitis. ( 29847189 )
2018
9
Vernal keratoconjunctivitis in human immunodeficiency virus - The possible role of T-helper 1-T-helper 2 shift. ( 29941754 )
2018
10
Vernal keratoconjunctivitis. ( 29391772 )
2018
11
Outcomes and Rationale of Excision and Mucous Membrane Grafting in Palpebral Vernal Keratoconjunctivitis. ( 29040121 )
2018
12
Comparative Evaluation of Tacrolimus Versus Interferon Alpha-2b Eye Drops in the Treatment of Vernal Keratoconjunctivitis: A Randomized, Double-Masked Study. ( 29040120 )
2018
13
Quality of life and clinical characterization of patients with vernal keratoconjunctivitis in a pediatric population in Colombia. ( 29338965 )
2018
14
Omalizumab as single-dose therapy for vernal keratoconjunctivitis. ( 30243989 )
2018
15
Vascular Endothelial Growth Factor (VEGF) Serological and Lacrimal Signaling in Patients Affected by Vernal Keratoconjunctivitis (VKC). ( 30305958 )
2018
16
Tacrolimus as an Effective and Safe Therapeutic Alternative in Vernal Keratoconjunctivitis Resistant to Conventional Treatment. ( 30350791 )
2018
17
Tear Ferning Test and Pathological Effects on Ocular Surface before and after Topical Cyclosporine in Vernal Keratoconjunctivitis Patients. ( 30405906 )
2018
18
Vernal Keratoconjunctivitis. ( 30550738 )
2018
19
Oral cyclosporine for severe vernal keratoconjunctivitis in children. ( 30551992 )
2018
20
Vernal Keratoconjunctivitis-When Medication Fails. ( 30581132 )
2018
21
A Randomized, Controlled Trial of Cyclosporine A Cationic Emulsion in Pediatric Vernal Keratoconjunctivitis: The VEKTIS Study. ( 30593775 )
2018
22
Tacrolimus eye drops as monotherapy for vernal keratoconjunctivitis: a randomized controlled trial. ( 28832739 )
2017
23
Supratarsal injection of triamcinolone for severe vernal keratoconjunctivitis in children. ( 28832741 )
2017
24
Long-term use of 0.003% tacrolimus suspension for treatment of vernal keratoconjunctivitis. ( 29118487 )
2017
25
Comparative Evaluation of Tacrolimus Versus Interferon Alpha-2b Eye Drops in the Treatment of Vernal Keratoconjunctivitis: A Randomized, Double-Masked Study. ( 28399035 )
2017
26
Kingella kingae Keratitis in a Child with Underlying Vernal Keratoconjunctivitis. ( 28546880 )
2017
27
Therapeutic Effect of 0.1% Tacrolimus Eye Drops in the Tarsal Form of Vernal Keratoconjunctivitis. ( 28803239 )
2017
28
Corneal Complications And Visual Impairment In Vernal Keratoconjunctivitis Patients. ( 28712175 )
2017
29
Corneal backward scattering and higher-order aberrations in children with vernal keratoconjunctivitis and normal topography. ( 29090512 )
2017
30
Sequential Keraring implantation and corneal cross-linking for the treatment of keratoconus in children with vernal keratoconjunctivitis. ( 29123375 )
2017
31
Vitamin D levels in children affected by vernal keratoconjunctivitis. ( 27786545 )
2017
32
Vernal keratoconjunctivitis treated with omalizumab: A case series. ( 28543949 )
2017
33
Efficacy and safety of low-dose topical tacrolimus in vernal keratoconjunctivitis. ( 27103784 )
2016
34
Omalizumab in Severe Refractory Vernal Keratoconjunctivitis in Children: Case Series and Review of the Literature. ( 27909980 )
2016
35
The Study of Interleukin-17 Level in Vernal Keratoconjunctivitis Disease and its Relationship between Symptom and Sign Severity. ( 27420560 )
2016
36
An Update on the Therapeutic Approach to Vernal Keratoconjunctivitis. ( 27461427 )
2016
37
New Finding in Vernal Keratoconjunctivitis: Splendore-Hoeppli Phenomenon. ( 27027918 )
2016
38
Vernal keratoconjunctivitis: culmination of management using immunosuppression, surgical and prosthetic therapy over quarter century. ( 27881591 )
2016
39
Serum Vitamin D Levels in Children with Vernal Keratoconjunctivitis. ( 27775457 )
2016
40
Chaperone patterns in vernal keratoconjunctivitis are distinctive of cell and Hsp type and are modified by inflammatory stimuli. ( 26613380 )
2016
41
Vernal Keratoconjunctivitis in Kashmir: A temperate zone. ( 26961753 )
2016
42
Impact of Vernal Keratoconjunctivitis on School Children in Egypt. ( 27128625 )
2016
43
Quiescent and Active Tear Protein Profiles to Predict Vernal Keratoconjunctivitis Reactivation. ( 26989694 )
2016
44
Vitiligo in association with vernal keratoconjunctivitis. ( 27330391 )
2016
45
Prevalence and associated factors of vernal keratoconjunctivitis among children in Gondar city, Northwest Ethiopia. ( 27681885 )
2016
46
Clinical Usefulness of Monitoring Expression Levels of CCL24 (Eotaxin-2) mRNA on the Ocular Surface in Patients with Vernal Keratoconjunctivitis and Atopic Keratoconjunctivitis. ( 27721987 )
2016
47
Tacrolimus in Corticosteroid-Refractory Vernal Keratoconjunctivitis. ( 27310883 )
2016
48
Omalizumab Treatment of Vernal Keratoconjunctivitis. ( 26795360 )
2016
49
Very low prevalence of keratoconus in a large series of vernal keratoconjunctivitis patients. ( 27640005 )
2016
50
Tacrolimus Ointment for Treatment of Vernal Keratoconjunctivitis. ( 26957853 )
2016

Variations for Vernal Keratoconjunctivitis

Expression for Vernal Keratoconjunctivitis

Search GEO for disease gene expression data for Vernal Keratoconjunctivitis.

Pathways for Vernal Keratoconjunctivitis

Pathways related to Vernal Keratoconjunctivitis according to GeneCards Suite gene sharing:

(show all 41)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.79 CCL11 CCL5 ICAM1 IL13 IL4 IL5
2
Show member pathways
13.63 CCL11 CCL5 CXCR3 IL13 IL4 IL5
3
Show member pathways
13.46 CCL11 CCL5 CXCR3 IL13 IL4 IL5
4
Show member pathways
13.33 CCL11 CCL5 ICAM1 IL13 IL4 IL5
5
Show member pathways
13.22 CCL11 CCL5 CXCR3 IL13 IL4 IL5
6
Show member pathways
13.19 CCL11 CCL5 CXCR3 ICAM1 MMP9
7
Show member pathways
13.16 CCL11 CCL5 ICAM1 IL13 IL4 IL5
8
Show member pathways
13.12 CCL11 CCL5 CXCR3 IL13 IL4 IL5
9
Show member pathways
12.71 CCL11 ICAM1 IL13 IL4 IL5 RNASE3
10 12.67 IL13 IL4 IL5 MMP9
11
Show member pathways
12.42 CCL5 ICAM1 IL13 IL4
12
Show member pathways
12.22 IL13 IL4 IL5
13
Show member pathways
12.18 CCL11 CCL5 ICAM1
14
Show member pathways
12.17 CCL5 ICAM1 IL4
15
Show member pathways
12.16 CCL11 IL13 IL4 IL5 MMP9
16
Show member pathways
12.07 CCL11 CCL5 CXCR3 ICAM1 MMP9
17
Show member pathways
11.9 IL13 IL4 MMP9
18 11.88 ICAM1 IL4 MMP9
19
Show member pathways
11.86 CCL11 CCL5 CXCR3
20 11.82 CCL5 ICAM1 MMP9
21
Show member pathways
11.75 CCL11 CCL5 ICAM1 IL13 IL4 IL5
22 11.69 ICAM1 IL13 IL4 IL5
23 11.66 CXCR3 IL13 IL4 IL5
24 11.61 CCL11 ICAM1 IL13 IL4 MMP9
25 11.56 CCL11 IL4 IL5
26 11.36 ICAM1 MMP9
27 11.36 CCL5 ICAM1 IL13 IL4
28 11.29 CCL11 IL13 IL4 IL5
29 11.27 CCL5 MMP9
30 11.23 IL13 IL4 IL5
31 11.2 CCL11 CXCR3
32 11.2 CCL11 CCL5 IL13 IL4 MMP9
33 11.19 IL4 IL5
34 11.17 IL13 IL4 IL5
35 11.16 CCL5 MMP9
36 11.12 IL13 IL4 IL5
37 11.05 ICAM1 MMP9
38 11.03 CCL11 CCL5 IL13 IL4 IL5
39 10.9 CCL11 CCL5 IL13 IL4 IL5 MMP9
40 10.87 CCL5 MMP9
41 10.86 CCL11 CCL5 IL13 IL4 IL5

GO Terms for Vernal Keratoconjunctivitis

Cellular components related to Vernal Keratoconjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 CCL11 CCL5 IL13 IL4 IL5 MMP9
2 extracellular space GO:0005615 9.23 CCL11 CCL5 ICAM1 IL13 IL4 IL5

Biological processes related to Vernal Keratoconjunctivitis according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.76 CCL11 CCL5 ICAM1
2 positive regulation of cell migration GO:0030335 9.74 CCL11 CCL5 MMP9
3 chemotaxis GO:0006935 9.7 CCL11 CCL5 CXCR3
4 cellular response to tumor necrosis factor GO:0071356 9.69 CCL11 CCL5 ICAM1
5 cellular response to interferon-gamma GO:0071346 9.67 CCL11 CCL5 ICAM1
6 cellular response to interleukin-1 GO:0071347 9.65 CCL11 CCL5 ICAM1
7 regulation of signaling receptor activity GO:0010469 9.65 CCL11 CCL5 IL13 IL4 IL5
8 chemokine-mediated signaling pathway GO:0070098 9.63 CCL11 CCL5 CXCR3
9 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.61 CCL5 IL13 IL4
10 monocyte chemotaxis GO:0002548 9.59 CCL11 CCL5
11 lymphocyte chemotaxis GO:0048247 9.58 CCL11 CCL5
12 leukocyte cell-cell adhesion GO:0007159 9.56 CCL5 ICAM1
13 positive regulation of JAK-STAT cascade GO:0046427 9.55 CCL5 IL5
14 inflammatory response GO:0006954 9.55 CCL11 CCL5 CXCR3 IL13 IL5
15 eosinophil chemotaxis GO:0048245 9.54 CCL11 CCL5
16 positive regulation of B cell proliferation GO:0030890 9.54 IL13 IL4 IL5
17 negative regulation of endothelial cell apoptotic process GO:2000352 9.5 ICAM1 IL13 IL4
18 immune response GO:0006955 9.43 CCL11 CCL5 CXCR3 IL13 IL4 IL5
19 negative regulation of complement-dependent cytotoxicity GO:1903660 9.4 IL13 IL4
20 cytokine-mediated signaling pathway GO:0019221 9.17 CCL11 CCL5 ICAM1 IL13 IL4 IL5

Molecular functions related to Vernal Keratoconjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 9.26 CCL11 CCL5
2 CCR chemokine receptor binding GO:0048020 9.16 CCL11 CCL5
3 cytokine activity GO:0005125 9.02 CCL11 CCL5 IL13 IL4 IL5
4 cytokine receptor binding GO:0005126 8.96 IL13 IL4

Sources for Vernal Keratoconjunctivitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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