VKC
MCID: VRN004
MIFTS: 56

Vernal Keratoconjunctivitis (VKC)

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Vernal Keratoconjunctivitis

MalaCards integrated aliases for Vernal Keratoconjunctivitis:

Name: Vernal Keratoconjunctivitis 53 59
Keratoconjunctivitis, Vernal 73
Keratoconjunctivitis Vernal 55
Spring Catarrh 59
Vkc 53

Characteristics:

Orphanet epidemiological data:

59
vernal keratoconjunctivitis
Inheritance: Not applicable; Age of onset: Childhood; Age of death: normal life expectancy;

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 59  
Rare eye diseases


External Ids:

Orphanet 59 ORPHA70476
UMLS via Orphanet 74 C0022577
ICD10 via Orphanet 34 H16.2
UMLS 73 C0022577

Summaries for Vernal Keratoconjunctivitis

NIH Rare Diseases : 53 Vernal keratoconjunctivitis (VKC) is a chronic, severe allergy that affects the surfaces of the eyes. It most commonly occurs in boys living in warm, dry climates. Attacks associated with VKC are common in the spring (hence the name "vernal") and summer but often reoccur in the winter. Signs and symptoms usually begin before 10 years of age and may include hard, cobblestone-like bumps (papillae) on the upper eyelid; sensitivity to light; redness; sticky mucus discharge; and involuntary blinking or spasms of the eyelid (blepharospasm). The condition usually subsides at the onset of puberty. It is caused by a hypersensitivity (allergic reaction) to airborne-allergens. Management focuses on preventing "flare ups" and relieving the symptoms of the condition.

MalaCards based summary : Vernal Keratoconjunctivitis, also known as keratoconjunctivitis, vernal, is related to keratoconjunctivitis and atopic keratoconjunctivitis. An important gene associated with Vernal Keratoconjunctivitis is RNASE3 (Ribonuclease A Family Member 3), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Tacrolimus and Tobramycin have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and endothelial, and related phenotypes are photophobia and pruritus

Wikipedia : 76 Vernal keratoconjunctivitis (VKC) or spring catarrh is a recurrent, bilateral, and self-limiting... more...

Related Diseases for Vernal Keratoconjunctivitis

Diseases related to Vernal Keratoconjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 173)
# Related Disease Score Top Affiliating Genes
1 keratoconjunctivitis 31.3 CCL11 ICAM1 IL13 IL4 IL5 RNASE3
2 atopic keratoconjunctivitis 30.6 IL4 IL5 RNASE3
3 papillary conjunctivitis 30.4 CCL11 IL4
4 vernal conjunctivitis 30.3 IL4 RNASE3
5 giant papillary conjunctivitis 30.3 CCL11 IL4 RNASE3
6 conjunctivitis 30.1 CCL11 ICAM1 IL13 IL4 IL5 RNASE3
7 allergic conjunctivitis 30.1 CCL11 ICAM1 IL13 IL4 IL5 RNASE3
8 uveitis 30.0 CXCR3 ICAM1 IL4
9 dermatitis 29.8 CCL11 IL13 IL4 IL5
10 allergic rhinitis 29.4 CCL11 ICAM1 IL13 IL4 IL5 RNASE3
11 allergic asthma 29.3 CCL11 CCL5 IL13 IL4 IL5 RNASE3
12 rhinitis 29.1 CCL11 CCL5 ICAM1 IL13 IL4 IL5
13 asthma 29.0 CCL11 CCL5 ICAM1 IL13 IL4 IL5
14 dermatitis, atopic 28.7 CCL11 CCL5 CXCR3 ICAM1 IL13 IL4
15 keratoconus 10.6
16 chlamydia 10.3
17 limbal stem cell deficiency 10.3
18 trachoma 10.3
19 conjunctival pigmentation 10.3
20 steroid-induced glaucoma 10.3
21 loeffler endocarditis 10.2 IL5 RNASE3
22 cow milk allergy 10.2 IL5 RNASE3
23 sinusitis 10.2 IL5 RNASE3
24 pemphigoid gestationis 10.2 CCL11 IL5
25 egg allergy 10.2 IL4 IL5
26 sulfamethoxazole allergy 10.2 IL4 IL5
27 gaucher disease, type ii 10.2 IL4 IL5
28 trichinosis 10.2 IL4 IL5
29 non-suppurative otitis media 10.2 IL4 IL5
30 filarial elephantiasis 10.2 IL4 IL5
31 wells syndrome 10.2 IL5 RNASE3
32 toxic oil syndrome 10.2 IL4 IL5
33 churg-strauss syndrome 10.2 IL5 RNASE3
34 maxillary sinusitis 10.1 CCL5 RNASE3
35 allergic bronchopulmonary aspergillosis 10.1 IL4 IL5
36 conjunctival nevus 10.1 MMP9 RNASE3
37 cellulitis 10.1 IL5 RNASE3
38 henoch-schoenlein purpura 10.1 ICAM1 RNASE3
39 diversion colitis 10.1 ICAM1 IL4
40 vulvovaginitis 10.1 CCL11 CCL5
41 collagenous colitis 10.1 MMP9 RNASE3
42 bardet-biedl syndrome 15 10.1 ICAM1 IL4
43 ocular cicatricial pemphigoid 10.1 IL4 RNASE3
44 blepharitis 10.1 CCL11 MMP9
45 poliomyelitis 10.1 ICAM1 IL4
46 trichomegaly 10.1
47 graft-versus-host disease 10.1
48 amblyopia 10.1
49 mooren's ulcer 10.1
50 corneal ectasia 10.1

Graphical network of the top 20 diseases related to Vernal Keratoconjunctivitis:



Diseases related to Vernal Keratoconjunctivitis

Symptoms & Phenotypes for Vernal Keratoconjunctivitis

Human phenotypes related to Vernal Keratoconjunctivitis:

59 32 (show all 12)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 photophobia 59 32 hallmark (90%) Very frequent (99-80%) HP:0000613
2 pruritus 59 32 hallmark (90%) Very frequent (99-80%) HP:0000989
3 corneal neovascularization 59 32 hallmark (90%) Very frequent (99-80%) HP:0011496
4 lacrimation abnormality 59 32 hallmark (90%) Very frequent (99-80%) HP:0000632
5 scarring 59 32 frequent (33%) Frequent (79-30%) HP:0100699
6 allergy 59 32 hallmark (90%) Very frequent (99-80%) HP:0012393
7 punctate keratitis 59 32 hallmark (90%) Very frequent (99-80%) HP:0011859
8 abnormality of the conjunctiva 59 Very frequent (99-80%)
9 abnormality of the cornea 59 Very frequent (99-80%)
10 abnormality of the sclera 59 Very frequent (99-80%)
11 abnormal conjunctiva morphology 32 hallmark (90%) HP:0000502
12 abnormal sclera morphology 32 hallmark (90%) HP:0000591

MGI Mouse Phenotypes related to Vernal Keratoconjunctivitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.76 CCL11 CCL5 CXCR3 ICAM1 IL13 IL4
2 digestive/alimentary MP:0005381 9.65 ICAM1 IL13 IL4 IL5 MMP9
3 immune system MP:0005387 9.56 CCL11 CCL5 CXCR3 ICAM1 IL13 IL4
4 respiratory system MP:0005388 9.1 CCL11 CXCR3 IL13 IL4 IL5 MMP9

Drugs & Therapeutics for Vernal Keratoconjunctivitis

Drugs for Vernal Keratoconjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 50)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 2 104987-11-3 445643 439492
2
Tobramycin Approved, Investigational Phase 4 32986-56-4 36294 5496
3
Loteprednol Approved, Experimental Phase 4 82034-46-6, 129260-79-3 9865442 444025
4
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
5
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
6
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 22916-47-8 4189
7
Histamine Approved, Investigational Phase 4,Phase 3 51-45-6, 75614-87-8 774
8
Glutamic Acid Approved, Nutraceutical Phase 4 56-86-0 33032
9 Immunologic Factors Phase 4,Phase 3,Phase 2
10 Ophthalmic Solutions Phase 4,Phase 3,Phase 2
11 Immunosuppressive Agents Phase 4,Phase 3,Phase 2
12 Calcineurin Inhibitors Phase 4,Phase 3,Phase 2
13 Anti-Allergic Agents Phase 4,Phase 3
14 Anti-Infective Agents Phase 4,Phase 3,Phase 2
15 Anti-Bacterial Agents Phase 4
16 Hormones Phase 4
17 Antineoplastic Agents, Hormonal Phase 4
18 Cyclosporins Phase 4,Phase 3,Phase 2
19 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2
20 Peripheral Nervous System Agents Phase 4
21 Gastrointestinal Agents Phase 4
22 glucocorticoids Phase 4
23 HIV Protease Inhibitors Phase 4
24 Hormone Antagonists Phase 4
25 Dermatologic Agents Phase 4,Phase 3,Phase 2
26
protease inhibitors Phase 4
27 Antifungal Agents Phase 4,Phase 3,Phase 2
28 Antirheumatic Agents Phase 4,Phase 3,Phase 2
29 Autonomic Agents Phase 4
30 Antiemetics Phase 4
31 BB 1101 Phase 4
32 Anti-Inflammatory Agents Phase 4
33 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
34 Respiratory System Agents Phase 4
35 Isospaglumic acid Phase 4
36 Histamine H1 Antagonists Phase 4,Phase 3
37 Histamine Antagonists Phase 4,Phase 3
38 Neurotransmitter Agents Phase 4,Phase 3
39 Anti-Asthmatic Agents Phase 4
40
Histamine Phosphate Phase 4,Phase 3 51-74-1 65513
41 Neuroprotective Agents Phase 4
42 Bronchodilator Agents Phase 4
43 Protective Agents Phase 4
44
Ketotifen Approved Phase 3 34580-14-8, 34580-13-7 3827
45 Antipruritics Phase 3
46 Acidophilus Phase 2, Phase 3
47 Antibodies, Monoclonal Phase 1
48 Immunoglobulin G Phase 1
49 Immunoglobulins Phase 1
50 Antibodies Phase 1

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 Topical Tacrolimus in Vernal Keratoconjunctivitis Unknown status NCT02456025 Phase 4 Topical tacrolimus
2 A Novel Combined Therapy for Refractory Vernal Keratoconjunctivitis Completed NCT03464435 Phase 4 Tacrolimus
3 Topical Cyclosporine for Vernal Keratoconjunctivitis (VKC) in Rwanda Completed NCT01211327 Phase 4 Cyclosporine A;Dexamethasone
4 Study of the Clinical and Biological Efficacity of NAAXIA SINE® in Vernal Keratoconjunctivitis Completed NCT00357019 Phase 4 N-acetyl-aspartyl-glutamate (NAAXIA Sine)
5 Double-Masked Trial of NOVA22007 (1mg/mL Ciclosporin/Cyclosporine) Versus Vehicle in Pediatric Patients With Active Severe Vernal Keratoconjunctivitis Completed NCT01751126 Phase 3 NOVA22007 ''Ciclosporin'';Placebo
6 Cyclosporin A Eye Drop Treatment in Vernal Keratoconjunctivitis Completed NCT00426023 Phase 3 Cyclosporine A 0,05% eye drop;ketotifen fumarate 0.025% eye drops
7 Lactobacillus Rhamnosus GG Oral Treatment Efficacy on Vernal Keratoconjunctivitis Treatment Completed NCT00445120 Phase 2, Phase 3 Lactobacillus Rhamnosus GG;placebo (sugar)
8 Phase III Study of 0.1% Tacrolimus(FK506) Ophthalmic Suspension in Patients With Vernal Keratoconjunctivitis Completed NCT00567762 Phase 3 FK506;placebo
9 Efficacy and Tolerance of Nova22007 Versus Vehicle in Patients With Vernal Keratoconjunctivitis (VKC) Completed NCT00328653 Phase 2, Phase 3 cyclosporine
10 Phase III, Long-Term, Open-Label, Extension Study of 0.1% Tacrolimus(FK506) Ophthalmic Suspension in Patients With Vernal Keratoconjunctivitis Completed NCT00567918 Phase 3 FK506
11 Efficacy Study of FK-506 and Cyclosporine in Vernal Keratoconjunctivits (VKC) Completed NCT01068054 Phase 2, Phase 3 tacrolimus;cyclosporins
12 A Study of AK002 in Patients With Atopic Keratoconjunctivitis, Vernal Keratoconjunctivitis, and Perennial Allergic Conjunctivitis Active, not recruiting NCT03379311 Phase 1 AK002
13 Cytokine Assay in Tears of Healthy Children and With Vernal Keratoconjunctivitis: Case Control Study and Monitoring of Cases at 6 Months Unknown status NCT02057822
14 Dermatologic Tacrolimus Ointment on Eyelids in the Treatment of Refractory Vernal Keratoconjunctivitis and Atopic Keratoconjunctivitis Recruiting NCT03557203
15 China Red Eye Study on Allergic Conjunctivitis Active, not recruiting NCT03812952

Search NIH Clinical Center for Vernal Keratoconjunctivitis

Genetic Tests for Vernal Keratoconjunctivitis

Anatomical Context for Vernal Keratoconjunctivitis

MalaCards organs/tissues related to Vernal Keratoconjunctivitis:

41
Eye, Testes, Endothelial, Thyroid, T Cells, Lung, Skin

Publications for Vernal Keratoconjunctivitis

Articles related to Vernal Keratoconjunctivitis:

(show top 50) (show all 340)
# Title Authors Year
1
Corneal staining patterns in vernal keratoconjunctivitis: the new VKC-CLEK scoring scale. ( 29367201 )
2018
2
Increased Lacrimal Fluid Level of HMGB1 in Vernal Keratoconjunctivitis. ( 29847189 )
2018
3
Vernal keratoconjunctivitis in human immunodeficiency virus - The possible role of T-helper 1-T-helper 2 shift. ( 29941754 )
2018
4
Vernal keratoconjunctivitis. ( 29391772 )
2018
5
Outcomes and Rationale of Excision and Mucous Membrane Grafting in Palpebral Vernal Keratoconjunctivitis. ( 29040121 )
2018
6
Comparative Evaluation of Tacrolimus Versus Interferon Alpha-2b Eye Drops in the Treatment of Vernal Keratoconjunctivitis: A Randomized, Double-Masked Study. ( 29040120 )
2018
7
Quality of life and clinical characterization of patients with vernal keratoconjunctivitis in a pediatric population in Colombia. ( 29338965 )
2018
8
Omalizumab as single-dose therapy for vernal keratoconjunctivitis. ( 30243989 )
2018
9
Vascular Endothelial Growth Factor (VEGF) Serological and Lacrimal Signaling in Patients Affected by Vernal Keratoconjunctivitis (VKC). ( 30305958 )
2018
10
Tacrolimus as an Effective and Safe Therapeutic Alternative in Vernal Keratoconjunctivitis Resistant to Conventional Treatment. ( 30350791 )
2018
11
Tear Ferning Test and Pathological Effects on Ocular Surface before and after Topical Cyclosporine in Vernal Keratoconjunctivitis Patients. ( 30405906 )
2018
12
Vernal Keratoconjunctivitis. ( 30550738 )
2018
13
Oral cyclosporine for severe vernal keratoconjunctivitis in children. ( 30551992 )
2018
14
Tacrolimus eye drops as monotherapy for vernal keratoconjunctivitis: a randomized controlled trial. ( 28832739 )
2017
15
Supratarsal injection of triamcinolone for severe vernal keratoconjunctivitis in children. ( 28832741 )
2017
16
Long-term use of 0.003% tacrolimus suspension for treatment of vernal keratoconjunctivitis. ( 29118487 )
2017
17
Comparative Evaluation of Tacrolimus Versus Interferon Alpha-2b Eye Drops in the Treatment of Vernal Keratoconjunctivitis: A Randomized, Double-Masked Study. ( 28399035 )
2017
18
Kingella kingae Keratitis in a Child with Underlying Vernal Keratoconjunctivitis. ( 28546880 )
2017
19
Therapeutic Effect of 0.1% Tacrolimus Eye Drops in the Tarsal Form of Vernal Keratoconjunctivitis. ( 28803239 )
2017
20
Corneal Complications And Visual Impairment In Vernal Keratoconjunctivitis Patients. ( 28712175 )
2017
21
Corneal backward scattering and higher-order aberrations in children with vernal keratoconjunctivitis and normal topography. ( 29090512 )
2017
22
Sequential Keraring implantation and corneal cross-linking for the treatment of keratoconus in children with vernal keratoconjunctivitis. ( 29123375 )
2017
23
Vitamin D levels in children affected by vernal keratoconjunctivitis. ( 27786545 )
2017
24
Vernal keratoconjunctivitis treated with omalizumab: A case series. ( 28543949 )
2017
25
Efficacy and safety of low-dose topical tacrolimus in vernal keratoconjunctivitis. ( 27103784 )
2016
26
Omalizumab in Severe Refractory Vernal Keratoconjunctivitis in Children: Case Series and Review of the Literature. ( 27909980 )
2016
27
The Study of Interleukin-17 Level in Vernal Keratoconjunctivitis Disease and its Relationship between Symptom and Sign Severity. ( 27420560 )
2016
28
An Update on the Therapeutic Approach to Vernal Keratoconjunctivitis. ( 27461427 )
2016
29
New Finding in Vernal Keratoconjunctivitis: Splendore-Hoeppli Phenomenon. ( 27027918 )
2016
30
Vernal keratoconjunctivitis: culmination of management using immunosuppression, surgical and prosthetic therapy over quarter century. ( 27881591 )
2016
31
Serum Vitamin D Levels in Children with Vernal Keratoconjunctivitis. ( 27775457 )
2016
32
Chaperone patterns in vernal keratoconjunctivitis are distinctive of cell and Hsp type and are modified by inflammatory stimuli. ( 26613380 )
2016
33
Vernal Keratoconjunctivitis in Kashmir: A temperate zone. ( 26961753 )
2016
34
Impact of Vernal Keratoconjunctivitis on School Children in Egypt. ( 27128625 )
2016
35
Quiescent and Active Tear Protein Profiles to Predict Vernal Keratoconjunctivitis Reactivation. ( 26989694 )
2016
36
Vitiligo in association with vernal keratoconjunctivitis. ( 27330391 )
2016
37
Prevalence and associated factors of vernal keratoconjunctivitis among children in Gondar city, Northwest Ethiopia. ( 27681885 )
2016
38
Clinical Usefulness of Monitoring Expression Levels of CCL24 (Eotaxin-2) mRNA on the Ocular Surface in Patients with Vernal Keratoconjunctivitis and Atopic Keratoconjunctivitis. ( 27721987 )
2016
39
Tacrolimus in Corticosteroid-Refractory Vernal Keratoconjunctivitis. ( 27310883 )
2016
40
Omalizumab Treatment of Vernal Keratoconjunctivitis. ( 26795360 )
2016
41
Very low prevalence of keratoconus in a large series of vernal keratoconjunctivitis patients. ( 27640005 )
2016
42
Tacrolimus Ointment for Treatment of Vernal Keratoconjunctivitis. ( 26957853 )
2016
43
Systematic approach to managing vernal keratoconjunctivitis in clinical practice: Severity grading system and a treatment algorithm. ( 27050351 )
2016
44
Is there is an association between the presence of Staphylococcus species and occurrence of vernal keratoconjunctivitis? ( 26586974 )
2015
45
Efficacy and safety of topical cyclosporine A 0.05% in vernal keratoconjunctivitis. ( 26768065 )
2015
46
Sex hormones in allergic conjunctivitis: altered levels of circulating androgens and estrogens in children and adolescents with vernal keratoconjunctivitis. ( 25756057 )
2015
47
A comprehensive review on vernal keratoconjunctivitis with emphasis on proteomics. ( 25744396 )
2015
48
In vivo confocal microscopy of meibomian glands and palpebral conjunctiva in vernal keratoconjunctivitis. ( 26044472 )
2015
49
Vernal Keratoconjunctivitis and immune-mediated diseases: One unique way to symptom control? ( 25692810 )
2015
50
Deep Anterior Lamellar Keratoplasty in Keratoconic Patients with versus without Vernal Keratoconjunctivitis. ( 26425311 )
2015

Variations for Vernal Keratoconjunctivitis

Expression for Vernal Keratoconjunctivitis

Search GEO for disease gene expression data for Vernal Keratoconjunctivitis.

Pathways for Vernal Keratoconjunctivitis

Pathways related to Vernal Keratoconjunctivitis according to GeneCards Suite gene sharing:

(show all 41)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.79 CCL11 CCL5 ICAM1 IL13 IL4 IL5
2
Show member pathways
13.63 CCL11 CCL5 CXCR3 IL13 IL4 IL5
3
Show member pathways
13.46 CCL11 CCL5 CXCR3 IL13 IL4 IL5
4
Show member pathways
13.33 CCL11 CCL5 ICAM1 IL13 IL4 IL5
5
Show member pathways
13.22 CCL11 CCL5 CXCR3 IL13 IL4 IL5
6
Show member pathways
13.19 CCL11 CCL5 CXCR3 ICAM1 MMP9
7
Show member pathways
13.16 CCL11 CCL5 ICAM1 IL13 IL4 IL5
8
Show member pathways
13.12 CCL11 CCL5 CXCR3 IL13 IL4 IL5
9
Show member pathways
12.71 CCL11 ICAM1 IL13 IL4 IL5 RNASE3
10 12.66 IL13 IL4 IL5 MMP9
11
Show member pathways
12.62 CCL5 ICAM1 IL13 IL4
12
Show member pathways
12.22 IL13 IL4 IL5
13
Show member pathways
12.18 CCL11 CCL5 ICAM1
14
Show member pathways
12.17 CCL5 ICAM1 IL4
15
Show member pathways
12.16 CCL11 IL13 IL4 IL5 MMP9
16
Show member pathways
12.07 CCL11 CCL5 CXCR3 ICAM1 MMP9
17
Show member pathways
11.9 IL13 IL4 MMP9
18 11.88 ICAM1 IL4 MMP9
19
Show member pathways
11.86 CCL11 CCL5 CXCR3
20 11.82 CCL5 ICAM1 MMP9
21
Show member pathways
11.75 CCL11 CCL5 ICAM1 IL13 IL4 IL5
22 11.69 ICAM1 IL13 IL4 IL5
23 11.66 CXCR3 IL13 IL4 IL5
24 11.61 CCL11 ICAM1 IL13 IL4 MMP9
25 11.56 CCL11 IL4 IL5
26 11.36 ICAM1 MMP9
27 11.36 CCL5 ICAM1 IL13 IL4
28 11.29 CCL11 IL13 IL4 IL5
29 11.27 CCL5 MMP9
30 11.23 IL13 IL4 IL5
31 11.2 CCL11 CXCR3
32 11.2 CCL11 CCL5 IL13 IL4 MMP9
33 11.19 IL4 IL5
34 11.17 IL13 IL4 IL5
35 11.16 CCL5 MMP9
36 11.12 IL13 IL4 IL5
37 11.05 ICAM1 MMP9
38 11.03 CCL11 CCL5 IL13 IL4 IL5
39 10.9 CCL11 CCL5 IL13 IL4 IL5 MMP9
40 10.87 CCL5 MMP9
41 10.86 CCL11 CCL5 IL13 IL4 IL5

GO Terms for Vernal Keratoconjunctivitis

Cellular components related to Vernal Keratoconjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 CCL11 CCL5 IL13 IL4 IL5 MMP9
2 extracellular space GO:0005615 9.23 CCL11 CCL5 ICAM1 IL13 IL4 IL5

Biological processes related to Vernal Keratoconjunctivitis according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.76 CCL11 CCL5 ICAM1
2 positive regulation of cell migration GO:0030335 9.74 CCL11 CCL5 MMP9
3 chemotaxis GO:0006935 9.7 CCL11 CCL5 CXCR3
4 cellular response to tumor necrosis factor GO:0071356 9.69 CCL11 CCL5 ICAM1
5 cellular response to interferon-gamma GO:0071346 9.67 CCL11 CCL5 ICAM1
6 cellular response to interleukin-1 GO:0071347 9.65 CCL11 CCL5 ICAM1
7 regulation of signaling receptor activity GO:0010469 9.65 CCL11 CCL5 IL13 IL4 IL5
8 chemokine-mediated signaling pathway GO:0070098 9.63 CCL11 CCL5 CXCR3
9 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.61 CCL5 IL13 IL4
10 monocyte chemotaxis GO:0002548 9.59 CCL11 CCL5
11 lymphocyte chemotaxis GO:0048247 9.58 CCL11 CCL5
12 leukocyte cell-cell adhesion GO:0007159 9.56 CCL5 ICAM1
13 positive regulation of JAK-STAT cascade GO:0046427 9.55 CCL5 IL5
14 inflammatory response GO:0006954 9.55 CCL11 CCL5 CXCR3 IL13 IL5
15 eosinophil chemotaxis GO:0048245 9.54 CCL11 CCL5
16 positive regulation of B cell proliferation GO:0030890 9.54 IL13 IL4 IL5
17 negative regulation of endothelial cell apoptotic process GO:2000352 9.5 ICAM1 IL13 IL4
18 immune response GO:0006955 9.43 CCL11 CCL5 CXCR3 IL13 IL4 IL5
19 negative regulation of complement-dependent cytotoxicity GO:1903660 9.4 IL13 IL4
20 cytokine-mediated signaling pathway GO:0019221 9.17 CCL11 CCL5 ICAM1 IL13 IL4 IL5

Molecular functions related to Vernal Keratoconjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 9.26 CCL11 CCL5
2 CCR chemokine receptor binding GO:0048020 9.16 CCL11 CCL5
3 cytokine activity GO:0005125 9.02 CCL11 CCL5 IL13 IL4 IL5
4 cytokine receptor binding GO:0005126 8.96 IL13 IL4

Sources for Vernal Keratoconjunctivitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....