MCID: VRR001
MIFTS: 23

Verrucous Papilloma

Categories: Cancer diseases

Aliases & Classifications for Verrucous Papilloma

MalaCards integrated aliases for Verrucous Papilloma:

Name: Verrucous Papilloma 12 15 72

Classifications:



External Ids:

Disease Ontology 12 DOID:3177
NCIt 50 C4101
SNOMED-CT 68 48218007
UMLS 72 C0334243

Summaries for Verrucous Papilloma

MalaCards based summary : Verrucous Papilloma is related to refractory hairy cell leukemia and cardiofaciocutaneous syndrome 1. An important gene associated with Verrucous Papilloma is BRAF (B-Raf Proto-Oncogene, Serine/Threonine Kinase), and among its related pathways/superpathways are Integrin Pathway and IL-2 Pathway. The drug Antioxidants has been mentioned in the context of this disorder. Related phenotypes are Decreased substrate adherent cell growth and Decreased substrate adherent cell growth

Related Diseases for Verrucous Papilloma

Diseases related to Verrucous Papilloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
# Related Disease Score Top Affiliating Genes
1 refractory hairy cell leukemia 9.9 MAP2K7 BRAF
2 cardiofaciocutaneous syndrome 1 9.7 MAP2K7 BRAF
3 lentigines 9.6 RAF1 BRAF
4 leopard syndrome 9.5 RAF1 BRAF
5 pilomyxoid astrocytoma 9.5 RAF1 BRAF
6 pulmonic stenosis 9.5 RAF1 BRAF
7 hypertelorism 9.4 RAF1 BRAF
8 cholangiocarcinoma 9.4 RAF1 BRAF
9 juvenile myelomonocytic leukemia 9.3 RAF1 BRAF
10 hypertrophic cardiomyopathy 9.1 RAF1 BRAF
11 large intestine cancer 9.1 RAF1 MAP2K7 BRAF

Graphical network of the top 20 diseases related to Verrucous Papilloma:



Diseases related to Verrucous Papilloma

Symptoms & Phenotypes for Verrucous Papilloma

GenomeRNAi Phenotypes related to Verrucous Papilloma according to GeneCards Suite gene sharing:

26 (show all 13)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased substrate adherent cell growth GR00193-A-1 9.76 RAF1
2 Decreased substrate adherent cell growth GR00193-A-2 9.76 MAP2K7 RAF1
3 Decreased substrate adherent cell growth GR00193-A-3 9.76 MAP2K7 BRAF
4 Decreased substrate adherent cell growth GR00193-A-4 9.76 BRAF
5 Decreased viability GR00055-A-2 9.65 BRAF
6 Decreased viability GR00221-A-1 9.65 RAF1
7 Decreased viability GR00221-A-2 9.65 RAF1
8 Decreased viability GR00221-A-4 9.65 BRAF
9 Decreased viability GR00231-A 9.65 RAF1
10 Decreased viability GR00301-A 9.65 BRAF RAF1
11 Decreased viability GR00381-A-1 9.65 BRAF
12 Decreased viability GR00402-S-2 9.65 BRAF RAF1
13 Increased simian virus 40 (SV40) infection GR00356-A-2 8.62 BRAF RAF1

MGI Mouse Phenotypes related to Verrucous Papilloma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.8 BRAF MAP2K7 RAF1

Drugs & Therapeutics for Verrucous Papilloma

Drugs for Verrucous Papilloma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antioxidants Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of VIUSID® Plus GLIZIGEN® in Patients With Papilloma Virus Esophageal. Phase II Clinical Trial Completed NCT03584308 Phase 2

Search NIH Clinical Center for Verrucous Papilloma

Genetic Tests for Verrucous Papilloma

Anatomical Context for Verrucous Papilloma

Publications for Verrucous Papilloma

Articles related to Verrucous Papilloma:

# Title Authors PMID Year
1
Squamous cell carcinomas are associated with verrucokeratotic cutaneous lesions but not with common warts in organ-transplant patients. A case-control study. 38
20559031 2010
2
Histopathological study of focal dermal hypoplasia (Goltz syndrome). 38
1424253 1992

Variations for Verrucous Papilloma

Expression for Verrucous Papilloma

Search GEO for disease gene expression data for Verrucous Papilloma.

Pathways for Verrucous Papilloma

Pathways related to Verrucous Papilloma according to GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.04 RAF1 MAP2K7 BRAF
2
Show member pathways
12.86 RAF1 MAP2K7 BRAF
3
Show member pathways
12.68 RAF1 MAP2K7 BRAF
4
Show member pathways
12.56 RAF1 MAP2K7 BRAF
5
Show member pathways
12.53 RAF1 MAP2K7 BRAF
6
Show member pathways
12.48 RAF1 MAP2K7 BRAF
7
Show member pathways
12.41 RAF1 MAP2K7 BRAF
8 12.34 RAF1 MAP2K7 BRAF
9
Show member pathways
12.28 RAF1 MAP2K7 BRAF
10
Show member pathways
12.26 RAF1 MAP2K7 BRAF
11
Show member pathways
12.25 RAF1 MAP2K7 BRAF
12
Show member pathways
12.1 RAF1 MAP2K7 BRAF
13
Show member pathways
12.09 RAF1 BRAF
14
Show member pathways
12.07 RAF1 BRAF
15 12.06 RAF1 BRAF
16
Show member pathways
12.04 RAF1 BRAF
17 12.04 RAF1 BRAF
18
Show member pathways
12 RAF1 MAP2K7 BRAF
19
Show member pathways
11.99 RAF1 BRAF
20
Show member pathways
11.97 RAF1 MAP2K7
21
Show member pathways
11.97 RAF1 MAP2K7
22
Show member pathways
11.94 RAF1 MAP2K7
23
Show member pathways
11.94 RAF1 BRAF
24 11.93 RAF1 BRAF
25
Show member pathways
11.92 RAF1 BRAF
26
Show member pathways
11.91 RAF1 MAP2K7
27
Show member pathways
11.9 RAF1 MAP2K7 BRAF
28
Show member pathways
11.89 RAF1 BRAF
29
Show member pathways
11.88 RAF1 MAP2K7
30
Show member pathways
11.86 RAF1 MAP2K7 BRAF
31
Show member pathways
11.84 RAF1 BRAF
32
Show member pathways
11.83 RAF1 BRAF
33
Show member pathways
11.79 MAP2K7 BRAF
34 11.78 RAF1 MAP2K7
35
Show member pathways
11.78 RAF1 BRAF
36 11.74 RAF1 BRAF
37 11.72 RAF1 BRAF
38 11.7 RAF1 BRAF
39 11.7 RAF1 BRAF
40
Show member pathways
11.69 RAF1 BRAF
41 11.69 RAF1 BRAF
42 11.68 RAF1 BRAF
43 11.64 RAF1 BRAF
44 11.63 RAF1 BRAF
45
Show member pathways
11.57 RAF1 BRAF
46 11.51 RAF1 BRAF
47 11.47 RAF1 BRAF
48
Show member pathways
11.44 RAF1 BRAF
49
Show member pathways
11.4 RAF1 BRAF
50 11.4 RAF1 BRAF

GO Terms for Verrucous Papilloma

Biological processes related to Verrucous Papilloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphorylation GO:0016310 9.58 RAF1 MAP2K7 BRAF
2 protein phosphorylation GO:0006468 9.54 RAF1 MAP2K7 BRAF
3 MAPK cascade GO:0000165 9.48 RAF1 BRAF
4 peptidyl-tyrosine phosphorylation GO:0018108 9.46 MAP2K7 BRAF
5 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.43 RAF1 BRAF
6 somatic stem cell population maintenance GO:0035019 9.32 RAF1 BRAF
7 activation of MAPKK activity GO:0000186 9.26 RAF1 BRAF
8 thymus development GO:0048538 9.16 RAF1 BRAF
9 thyroid gland development GO:0030878 8.96 RAF1 BRAF
10 face development GO:0060324 8.62 RAF1 BRAF

Molecular functions related to Verrucous Papilloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATP binding GO:0005524 9.61 RAF1 MAP2K7 BRAF
2 kinase activity GO:0016301 9.54 RAF1 MAP2K7 BRAF
3 protein kinase activity GO:0004672 9.5 RAF1 MAP2K7 BRAF
4 protein serine/threonine kinase activity GO:0004674 9.43 RAF1 MAP2K7 BRAF
5 protein tyrosine kinase activity GO:0004713 9.4 MAP2K7 BRAF
6 MAP kinase kinase kinase activity GO:0004709 9.16 RAF1 BRAF
7 small GTPase binding GO:0031267 8.96 RAF1 BRAF
8 mitogen-activated protein kinase kinase binding GO:0031434 8.62 RAF1 BRAF

Sources for Verrucous Papilloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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