MCID: VRT002
MIFTS: 30

Vertebral Artery Insufficiency

Categories: Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Vertebral Artery Insufficiency

MalaCards integrated aliases for Vertebral Artery Insufficiency:

Name: Vertebral Artery Insufficiency 12 15 71
Vertebral Artery Syndrome 12 71
Vertebrobasilar Insufficiency 43

Classifications:



External Ids:

Disease Ontology 12 DOID:13095
MeSH 43 D014715
UMLS 71 C0042560 C2931914

Summaries for Vertebral Artery Insufficiency

MalaCards based summary : Vertebral Artery Insufficiency, also known as vertebral artery syndrome, is related to achromatopsia and lateral medullary syndrome. An important gene associated with Vertebral Artery Insufficiency is SCAI (Suppressor Of Cancer Cell Invasion). The drugs Paclitaxel and Albumin-Bound Paclitaxel have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and spinal cord.

Related Diseases for Vertebral Artery Insufficiency

Diseases related to Vertebral Artery Insufficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 88)
# Related Disease Score Top Affiliating Genes
1 achromatopsia 29.2 RGS9BP KCNV2
2 lateral medullary syndrome 12.0
3 subclavian steal syndrome 11.7
4 pathologic nystagmus 10.5
5 syncope 10.3
6 spondylosis, cervical 10.3
7 spondylosis 10.3
8 ataxia and polyneuropathy, adult-onset 10.2
9 yemenite deaf-blind hypopigmentation syndrome 10.2
10 branchiootic syndrome 1 10.2
11 pica disease 10.2
12 vascular disease 10.2
13 carotid artery disease 10.2
14 cerebrovascular disease 10.2
15 sleep apnea 10.1
16 amnestic disorder 10.1
17 cortical blindness 10.1
18 basilar artery occlusion 10.1
19 vestibular nystagmus 10.1
20 encephalomalacia 10.1
21 transient cerebral ischemia 10.1
22 bow hunter's stroke 10.1
23 vertebrobasilar insufficiency 10.0
24 exostosis 10.0
25 atherosclerosis susceptibility 9.9
26 cardiac arrhythmia 9.9
27 deafness, unilateral 9.9
28 hypercholesterolemia, familial, 1 9.9
29 rheumatoid arthritis 9.9
30 syringomyelia, noncommunicating isolated 9.9
31 ocular motor apraxia 9.9
32 kearns-sayre syndrome 9.9
33 stroke, ischemic 9.9
34 major affective disorder 5 9.9
35 major affective disorder 6 9.9
36 muscle hypertrophy 9.9
37 alkuraya-kucinskas syndrome 9.9
38 distal arthrogryposis 9.9
39 vitamin b12 deficiency 9.9
40 limb ischemia 9.9
41 ptosis 9.9
42 mixed sleep apnea 9.9
43 transient global amnesia 9.9
44 dementia 9.9
45 acute kidney failure 9.9
46 thoracic outlet syndrome 9.9
47 syringomyelia 9.9
48 brain stem infarction 9.9
49 cranial nerve palsy 9.9
50 insulinoma 9.9

Comorbidity relations with Vertebral Artery Insufficiency via Phenotypic Disease Network (PDN): (show all 23)


Acute Cystitis Anxiety
Aortic Valve Disease 1 Basilar Artery Insufficiency
Benign Essential Hypertension Cerebral Atherosclerosis
Cerebrovascular Disease Deficiency Anemia
Esophagitis Familial Atrial Fibrillation
Generalized Atherosclerosis Heart Disease
Hypertension, Essential Hypothyroidism
Intermediate Coronary Syndrome Labyrinthitis
Malignant Essential Hypertension Mitral Valve Disease
Peripheral Vascular Disease Sinoatrial Node Disease
Subclavian Steal Syndrome Transient Cerebral Ischemia
Vertigo, Benign Recurrent

Graphical network of the top 20 diseases related to Vertebral Artery Insufficiency:



Diseases related to Vertebral Artery Insufficiency

Symptoms & Phenotypes for Vertebral Artery Insufficiency

Drugs & Therapeutics for Vertebral Artery Insufficiency

Drugs for Vertebral Artery Insufficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Paclitaxel Approved, Vet_approved Phase 2, Phase 3 33069-62-4 36314
2 Albumin-Bound Paclitaxel Phase 2, Phase 3
3
Sirolimus Approved, Investigational 53123-88-9 5284616 6436030 46835353
4 Complement C3

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 A Randomized Trial for Treatment of Symptomatic Extracranial Vertebral Artery Stenosis: Drug Eluting Stents Versus Bare Metal Stents Completed NCT03201432 Phase 2, Phase 3
2 Drug-coated Balloon Angioplasty for Patients With Symptomatic Vertebral Artery Stenosis Unknown status NCT03504657 Phase 2
3 Clinical Results and Restenosis Analysis of Symptomatic Ostial Vertebral Artery Stenosis Treated With Tubular Coronary Stents Unknown status NCT00172458
4 Remote Ischemic Conditioning for Reducing Stroke Risk of Symptomatic Vertebrobasilar Lesion of Atherosclerosis Unknown status NCT02971462
5 Prospective Multi-center Single-arm Target Value Clinical Trial for Evaluating Clinical Use Safety and Efficacy of the Firehorus Vertebral Artery Rapamycin-target-eluting Stent System Completed NCT02328781
6 Effects of High Inspiratory Oxygen on Cerebral Tissue Oxygenation and Patient Recovery After Carotid Endarterectomy Completed NCT02991976
7 The Vertebrobasilar Flow Evaluation and Risk of Transient Ischemic Attack and Stroke (VERiTAS) Study Completed NCT00590980
8 Comparison the Effects of Manual and Instrumental Chiropractic Spinal Manipulation on Vertebrobasilar and Internal Carotis Arteries in Healthy Population Completed NCT03435159
9 Immediate Effect of a Single Cervical Spinal Manipulation on Cervical Movement Pattern Completed NCT04059692
10 Vertebral Artery Origin Treatment Via Endovascular Techniques Registry (VOTER) Recruiting NCT03999983
11 Outpatient Office Based Endovascular Procedures Enrolling by invitation NCT04054440
12 Vertebrobasilar Flow Evaluation and Risk of Transient Ischemic Attack and Stroke II (VERiTASII) Not yet recruiting NCT03729817

Search NIH Clinical Center for Vertebral Artery Insufficiency

Cochrane evidence based reviews: vertebrobasilar insufficiency

Genetic Tests for Vertebral Artery Insufficiency

Anatomical Context for Vertebral Artery Insufficiency

MalaCards organs/tissues related to Vertebral Artery Insufficiency:

40
Eye, Brain, Spinal Cord

Publications for Vertebral Artery Insufficiency

Articles related to Vertebral Artery Insufficiency:

(show top 50) (show all 85)
# Title Authors PMID Year
1
Rotational vertebral artery syndrome treated via an anterior approach and selective decompression only. 61
31886151 2019
2
[The use of the osteopathic correction for the combined treatment and rehabilitation of the patients presenting with the vertebral artery syndrome]. 61
30499484 2018
3
Surgical Treatment of Rotational Vertebral Artery Syndrome Induced by Spinal Tumor: A Case Report and Literature Review. 61
29018650 2017
4
Ocular Manifestation of a Cervical Spine Injury: An Adult Case of Traumatic Atlantoaxial Rotatory Subluxation Manifesting with Nystagmus. 61
28254538 2017
5
Teaching NeuroImages: Dynamic vertebral artery insufficiency. 61
27906667 2016
6
A Case of Rotational Vertebral Artery Syndrome. 61
25118574 2016
7
Subaxial rotational vertebral artery syndrome: resection of the uncinate process and anterior fusion can be sufficient!: case report and review of the literature. 61
23429312 2015
8
Cervicogenic causes of vertigo. 61
25502050 2015
9
Bow hunter's syndrome causing vertebrobasilar insufficiency in a young man with neck muscle hypertrophy. 61
24184499 2014
10
[Algorithm for the diagnosis of the vertebral artery compression syndrome based on sensitivity of ultrasound and angiographic methods]. 61
25286599 2014
11
Rotational vertebral artery syndrome in moyamoya disease: a sign of unilateral vertebral artery stenosis. 61
23759342 2013
12
Rare case of bilateral vertebral artery stenosis caused by C4-5 spondylotic changes manifesting with bilateral bow hunter's syndrome. 61
22722045 2013
13
Rotational vertebral artery syndrome. 61
22858848 2013
14
[The vertebral artery syndrome and patient management tactics]. 61
23388592 2012
15
Check your vestibular skills by reading about the rotational vertebral artery syndrome. 61
21948085 2011
16
Origin of isolated vertigo in rotational vertebral artery syndrome. 61
21710126 2011
17
Rotational vertebral artery syndrome due to compression of nondominant vertebral artery terminating in posterior inferior cerebellar artery. 61
21416208 2011
18
[Mexiprim in the complex treatment of patients with cervical dorsopathy and the vertebral artery syndrome]. 61
22611675 2011
19
Rotational vertebral artery occlusion-series of 9 cases. 61
20881570 2010
20
Rotational vertebral artery syndrome: 3D kinematics of nystagmus suggest bilateral labyrinthine dysfunction. 61
18274804 2008
21
Fatal cerebellar stroke following emergency endovascular stent grafting of a leaking thoracic aortic aneurysm: A case report. 61
22477374 2008
22
[The vegetative status in patients with vertebrogenic vertebral artery syndrome, and its correction with health resort treatment]. 61
18326284 2008
23
Rotational vertebral artery insufficiency resulting from cervical spondylosis: case report and review of the literature. 61
16720191 2006
24
[Clinical observation of puerarin in treating patients with vertebral artery insufficiency due to cervical spondylosis: a report of 123 cases]. 61
16409979 2006
25
Rotational vertebral artery syndrome: oculographic analysis of nystagmus. 61
16247059 2005
26
Cerebellar infarction secondary to os odontoideum. 61
12948474 2003
27
Vertebral artery insufficiency as a possible mechanism for sudden infant death--in vivo evidence does not support findings from postmortem studies. 61
12850510 2003
28
[Bilateral sensorineural hearing loss due to vertebral artery insufficiency]. 61
11676168 2001
29
A possible correlation between vertebral artery insufficiency and degenerative changes in the cervical spine. 61
9833209 1998
30
Symptoms of neck artery compromise: case presentations of risk estimate for treatment. 61
9168413 1997
31
Vertebral artery occlusion associated with cervical spine trauma. A prospective analysis. 61
9122799 1997
32
[Evaluation of syncope in medicolegal expertise]. 61
7800390 1994
33
[The use of xidifon in the vertebral artery syndrome during exacerbation]. 61
1666232 1991
34
[Clinical and expert opinion aspects of vertebrobasilar insufficiency]. 61
2158721 1990
35
[The diagnosis and treatment of patients with the vascular syndromes of cervical osteochondrosis]. 61
2168627 1990
36
[Periarterial alcoholization of the vertebral artery in vertebrogenic lesions]. 61
4036441 1985
37
[Another new etiology of vertebral artery insufficiency--a case of dynamic entrapment of the vertebral artery by the cervical nerve]. 61
4020225 1985
38
[A decompression procedure for vertebral artery insufficiency in cervical spondylosis]. 61
6543750 1984
39
[The operative treatment of the cervico-encephalic syndrome or the vertebral artery syndrome]. 61
7103911 1982
40
[Disability evaluation of patients with cervical osteochondrosis and a vertebral artery syndrome]. 61
6982573 1982
41
[Choice of operative methods for vertebral artery syndrome in patients with cervical osteochondrosis]. 61
491418 1979
42
Decompression of vertebral artery in cases of cervical spondylosis. 61
675497 1978
43
Surgical treatment of vertebral artery insufficiency in patients with diagnosis of multiple sclerosis. 61
615387 1977
44
[Means of experimentally reproducing the vertebral artery syndrome]. 61
856336 1977
45
Surgical treatment of partial extraluminal occlusion of first part of vertebral artery. 61
997774 1976
46
[Effectiveness of radon baths of different concentration in the treatment of cervical osteochondrosis with the vertebral artery syndrome]. 61
1014430 1976
47
The management of vertebral artery insufficiency in cervical spondylosis: a modified technique. 61
1067075 1976
48
Basilar-vertebral artery insufficiency as a cause of vertigo. 61
4220283 1973
49
[Paraplegia and vertebral artery insufficiency caused by cervical spine involvement in chronic polyarthritis]. 61
4790199 1973
50
[Dynamics of the eye symptoms in the vertebral artery syndrome being treated at a health resort]. 61
4754078 1973

Variations for Vertebral Artery Insufficiency

Expression for Vertebral Artery Insufficiency

Search GEO for disease gene expression data for Vertebral Artery Insufficiency.

Pathways for Vertebral Artery Insufficiency

GO Terms for Vertebral Artery Insufficiency

Biological processes related to Vertebral Artery Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of signal transduction GO:0009968 8.62 SCAI RGS9BP

Sources for Vertebral Artery Insufficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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