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MCID: VRT002
MIFTS: 29

Vertebral Artery Insufficiency

Categories: Cardiovascular diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Vertebral Artery Insufficiency

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MalaCards integrated aliases for Vertebral Artery Insufficiency:

Name: Vertebral Artery Insufficiency 12 15 72
Vertebral Artery Syndrome 12 72

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases Neuronal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:13095
MeSH 44 D014715
UMLS 72 C0042560 C2931914
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Summaries for Vertebral Artery Insufficiency

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MalaCards based summary : Vertebral Artery Insufficiency, also known as vertebral artery syndrome, is related to lateral medullary syndrome and spondylosis, cervical. An important gene associated with Vertebral Artery Insufficiency is PCLO (Piccolo Presynaptic Cytomatrix Protein), and among its related pathways/superpathways are Statin Pathway and amb2 Integrin signaling. Affiliated tissues include brain, eye and spinal cord, and related phenotype is Decreased free cholesterol.

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Related Diseases for Vertebral Artery Insufficiency

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Diseases related to Vertebral Artery Insufficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
# Related Disease Score Top Affiliating Genes
1 lateral medullary syndrome 12.0
2 spondylosis, cervical 10.3
3 spondylosis 10.3
4 lipoprotein glomerulopathy 10.2 LPA APOB
5 huntington disease-like 1 10.2 LPA APOB
6 leukodystrophy, hypomyelinating, 3 10.2 LPA APOB
7 hypolipoproteinemia 10.2 LPA APOB
8 hypobetalipoproteinemia, familial, 2 10.2 LPA APOB
9 xanthomatosis 10.2 LPA APOB
10 hyperlipoproteinemia, type iii 10.2 LPA APOB
11 arcus corneae 10.2 LPA APOB
12 lecithin:cholesterol acyltransferase deficiency 10.2 LPA APOB
13 carotid artery disease 10.2 LPA APOB
14 tangier disease 10.1 LPA APOB
15 peripheral vascular disease 10.1 LPA APOB
16 familial hyperlipidemia 10.1 LPA APOB
17 osteochondrosis 10.1
18 arteries, anomalies of 10.1 LPA APOB
19 lipid metabolism disorder 10.1 LPA APOB
20 pathologic nystagmus 10.0
21 aortic valve disease 1 10.0 LPA APOB
22 vertebrobasilar insufficiency 10.0
23 exostosis 10.0
24 atherosclerosis susceptibility 10.0 LPA APOB
25 coronary artery anomaly 9.9 LPA APOB
26 ataxia and polyneuropathy, adult-onset 9.9
27 sudden infant death syndrome 9.9
28 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.9
29 sensorineural hearing loss 9.9
30 vertebral artery occlusion 9.9
31 basilar artery insufficiency 9.9
32 paraplegia 9.9
33 osteoarthritis 9.9
34 spinal cord injury 9.9
35 coronary heart disease 1 9.8 LPA APOB
36 moyamoya disease 1 9.7
37 mucopolysaccharidosis, type ii 9.7
38 pica disease 9.7
39 subclavian steal syndrome 9.7
40 inner ear disease 9.7
41 osteochondroma 9.7
42 arteriosclerosis 9.6 LPA APOB

Comorbidity relations with Vertebral Artery Insufficiency via Phenotypic Disease Network (PDN): (show all 23)


Acute Cystitis Anxiety
Aortic Valve Disease 1 Basilar Artery Insufficiency
Benign Essential Hypertension Cerebral Atherosclerosis
Cerebrovascular Disease Deficiency Anemia
Esophagitis Familial Atrial Fibrillation
Generalized Atherosclerosis Heart Disease
Hypertension, Essential Hypothyroidism
Intermediate Coronary Syndrome Labyrinthitis
Malignant Essential Hypertension Mitral Valve Disease
Peripheral Vascular Disease Sinoatrial Node Disease
Subclavian Steal Syndrome Transient Cerebral Ischemia
Vertigo, Benign Recurrent

Graphical network of the top 20 diseases related to Vertebral Artery Insufficiency:



Diseases related to Vertebral Artery Insufficiency
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Symptoms & Phenotypes for Vertebral Artery Insufficiency

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GenomeRNAi Phenotypes related to Vertebral Artery Insufficiency according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased free cholesterol GR00340-A-2 8.62 APOB LPA
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Drugs & Therapeutics for Vertebral Artery Insufficiency

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Search Clinical Trials , NIH Clinical Center for Vertebral Artery Insufficiency

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Genetic Tests for Vertebral Artery Insufficiency

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Anatomical Context for Vertebral Artery Insufficiency

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MalaCards organs/tissues related to Vertebral Artery Insufficiency:

41
Brain, Eye, Spinal Cord
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Publications for Vertebral Artery Insufficiency

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Articles related to Vertebral Artery Insufficiency:

(show top 50) (show all 84)
# Title Authors PMID Year
1
[The use of the osteopathic correction for the combined treatment and rehabilitation of the patients presenting with the vertebral artery syndrome]. 38
30499484 2018
2
Surgical Treatment of Rotational Vertebral Artery Syndrome Induced by Spinal Tumor: A Case Report and Literature Review. 38
29018650 2017
3
Ocular Manifestation of a Cervical Spine Injury: An Adult Case of Traumatic Atlantoaxial Rotatory Subluxation Manifesting with Nystagmus. 38
28254538 2017
4
Teaching NeuroImages: Dynamic vertebral artery insufficiency. 38
27906667 2016
5
A Case of Rotational Vertebral Artery Syndrome. 38
25118574 2016
6
Subaxial rotational vertebral artery syndrome: resection of the uncinate process and anterior fusion can be sufficient!: case report and review of the literature. 38
23429312 2015
7
Cervicogenic causes of vertigo. 38
25502050 2015
8
Bow hunter's syndrome causing vertebrobasilar insufficiency in a young man with neck muscle hypertrophy. 38
24184499 2014
9
[Algorithm for the diagnosis of the vertebral artery compression syndrome based on sensitivity of ultrasound and angiographic methods]. 38
25286599 2014
10
Rotational vertebral artery syndrome in moyamoya disease: a sign of unilateral vertebral artery stenosis. 38
23759342 2013
11
Rare case of bilateral vertebral artery stenosis caused by C4-5 spondylotic changes manifesting with bilateral bow hunter's syndrome. 38
22722045 2013
12
Rotational vertebral artery syndrome. 38
22858848 2013
13
[The vertebral artery syndrome and patient management tactics]. 38
23388592 2012
14
Check your vestibular skills by reading about the rotational vertebral artery syndrome. 38
21948085 2011
15
Origin of isolated vertigo in rotational vertebral artery syndrome. 38
21710126 2011
16
Rotational vertebral artery syndrome due to compression of nondominant vertebral artery terminating in posterior inferior cerebellar artery. 38
21416208 2011
17
[Mexiprim in the complex treatment of patients with cervical dorsopathy and the vertebral artery syndrome]. 38
22611675 2011
18
Rotational vertebral artery occlusion-series of 9 cases. 38
20881570 2010
19
Rotational vertebral artery syndrome: 3D kinematics of nystagmus suggest bilateral labyrinthine dysfunction. 38
18274804 2008
20
Fatal cerebellar stroke following emergency endovascular stent grafting of a leaking thoracic aortic aneurysm: A case report. 38
22477374 2008
21
[The vegetative status in patients with vertebrogenic vertebral artery syndrome, and its correction with health resort treatment]. 38
18326284 2008
22
Rotational vertebral artery insufficiency resulting from cervical spondylosis: case report and review of the literature. 38
16720191 2006
23
[Clinical observation of puerarin in treating patients with vertebral artery insufficiency due to cervical spondylosis: a report of 123 cases]. 38
16409979 2006
24
Rotational vertebral artery syndrome: oculographic analysis of nystagmus. 38
16247059 2005
25
Cerebellar infarction secondary to os odontoideum. 38
12948474 2003
26
Vertebral artery insufficiency as a possible mechanism for sudden infant death--in vivo evidence does not support findings from postmortem studies. 38
12850510 2003
27
[Bilateral sensorineural hearing loss due to vertebral artery insufficiency]. 38
11676168 2001
28
A possible correlation between vertebral artery insufficiency and degenerative changes in the cervical spine. 38
9833209 1998
29
Symptoms of neck artery compromise: case presentations of risk estimate for treatment. 38
9168413 1997
30
Vertebral artery occlusion associated with cervical spine trauma. A prospective analysis. 38
9122799 1997
31
[Evaluation of syncope in medicolegal expertise]. 38
7800390 1994
32
[The use of xidifon in the vertebral artery syndrome during exacerbation]. 38
1666232 1991
33
[Clinical and expert opinion aspects of vertebrobasilar insufficiency]. 38
2158721 1990
34
[The diagnosis and treatment of patients with the vascular syndromes of cervical osteochondrosis]. 38
2168627 1990
35
[Periarterial alcoholization of the vertebral artery in vertebrogenic lesions]. 38
4036441 1985
36
[Another new etiology of vertebral artery insufficiency--a case of dynamic entrapment of the vertebral artery by the cervical nerve]. 38
4020225 1985
37
[A decompression procedure for vertebral artery insufficiency in cervical spondylosis]. 38
6543750 1984
38
[The operative treatment of the cervico-encephalic syndrome or the vertebral artery syndrome]. 38
7103911 1982
39
[Disability evaluation of patients with cervical osteochondrosis and a vertebral artery syndrome]. 38
6982573 1982
40
[Choice of operative methods for vertebral artery syndrome in patients with cervical osteochondrosis]. 38
491418 1979
41
Decompression of vertebral artery in cases of cervical spondylosis. 38
675497 1978
42
Surgical treatment of vertebral artery insufficiency in patients with diagnosis of multiple sclerosis. 38
615387 1977
43
[Means of experimentally reproducing the vertebral artery syndrome]. 38
856336 1977
44
Surgical treatment of partial extraluminal occlusion of first part of vertebral artery. 38
997774 1976
45
[Effectiveness of radon baths of different concentration in the treatment of cervical osteochondrosis with the vertebral artery syndrome]. 38
1014430 1976
46
The management of vertebral artery insufficiency in cervical spondylosis: a modified technique. 38
1067075 1976
47
Basilar-vertebral artery insufficiency as a cause of vertigo. 38
4220283 1973
48
[Paraplegia and vertebral artery insufficiency caused by cervical spine involvement in chronic polyarthritis]. 38
4790199 1973
49
[Dynamics of the eye symptoms in the vertebral artery syndrome being treated at a health resort]. 38
4754078 1973
50
[Errors in the differential diagnosis between brain tumors and the vertebrogenic vertebral artery syndrome]. 38
4659869 1972
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Variations for Vertebral Artery Insufficiency

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Expression for Vertebral Artery Insufficiency

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Search GEO for disease gene expression data for Vertebral Artery Insufficiency.
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Pathways for Vertebral Artery Insufficiency

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Pathways related to Vertebral Artery Insufficiency according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Statin Pathway 1
Show member pathways
 11.03 LPA APOB
2
amb2 Integrin signaling 1
10.3 LPA APOB
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GO Terms for Vertebral Artery Insufficiency

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Biological processes related to Vertebral Artery Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipid transport GO:0006869 8.96 LPA APOB
2 low-density lipoprotein particle remodeling GO:0034374 8.62 LPA APOB
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Sources for Vertebral Artery Insufficiency

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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