MCID: VRT002
MIFTS: 24

Vertebral Artery Insufficiency

Categories: Cardiovascular diseases

Aliases & Classifications for Vertebral Artery Insufficiency

MalaCards integrated aliases for Vertebral Artery Insufficiency:

Name: Vertebral Artery Insufficiency 12 15 74
Vertebral Artery Syndrome 12 74

Classifications:



External Ids:

Disease Ontology 12 DOID:13095
MeSH 45 D014715

Summaries for Vertebral Artery Insufficiency

MalaCards based summary : Vertebral Artery Insufficiency, also known as vertebral artery syndrome, is related to lateral medullary syndrome and spondylosis. An important gene associated with Vertebral Artery Insufficiency is AARS (Alanyl-TRNA Synthetase), and among its related pathways/superpathways are Statin Pathway and amb2 Integrin signaling. Affiliated tissues include spinal cord, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Vertebral Artery Insufficiency

Diseases related to Vertebral Artery Insufficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 31)
# Related Disease Score Top Affiliating Genes
1 lateral medullary syndrome 11.8
2 spondylosis 10.2
3 huntington disease-like 1 10.0 APOB LPA
4 lipoprotein glomerulopathy 10.0 APOB LPA
5 leukodystrophy, hypomyelinating, 3 10.0 APOB LPA
6 hyperlipidemia, familial combined 10.0 APOB LPA
7 hypolipoproteinemia 10.0 APOB LPA
8 hypobetalipoproteinemia, familial, 2 10.0 APOB LPA
9 xanthomatosis 10.0 APOB LPA
10 hyperlipoproteinemia, type iii 10.0 APOB LPA
11 arcus corneae 10.0 APOB LPA
12 lecithin:cholesterol acyltransferase deficiency 10.0 APOB LPA
13 carotid artery disease 9.9 APOB LPA
14 tangier disease 9.9 APOB LPA
15 peripheral vascular disease 9.9 APOB LPA
16 familial hyperlipidemia 9.9 APOB LPA
17 arteries, anomalies of 9.9 APOB LPA
18 lipid metabolism disorder 9.9 APOB LPA
19 pathologic nystagmus 9.9
20 atherosclerosis susceptibility 9.9 APOB LPA
21 aortic valve disease 1 9.9 APOB LPA
22 coronary artery anomaly 9.9 APOB LPA
23 multiple sclerosis 9.8
24 osteoarthritis 9.8
25 spinal cord injury 9.8
26 coronary heart disease 1 9.8 APOB LPA
27 arteriosclerosis 9.8 APOB LPA
28 moyamoya disease 1 9.7
29 inner ear disease 9.7
30 hypercholesterolemia, familial 9.7 APOB LPA
31 chronic kidney failure 9.6 APOB LPA

Comorbidity relations with Vertebral Artery Insufficiency via Phenotypic Disease Network (PDN): (show all 25)


Acute Cystitis Anxiety
Aortic Valve Disease 1 Basilar Artery Insufficiency
Benign Essential Hypertension Cerebral Atherosclerosis
Cerebrovascular Disease Chronic Myocardial Ischemia
Deficiency Anemia Esophagitis
Familial Atrial Fibrillation Generalized Atherosclerosis
Heart Disease Hypertension, Essential
Hypothyroidism Intermediate Coronary Syndrome
Ischemic Heart Disease Labyrinthitis
Malignant Essential Hypertension Mitral Valve Disease
Peripheral Vascular Disease Sinoatrial Node Disease
Subclavian Steal Syndrome Transient Cerebral Ischemia
Vertigo, Benign Recurrent

Graphical network of the top 20 diseases related to Vertebral Artery Insufficiency:



Diseases related to Vertebral Artery Insufficiency

Symptoms & Phenotypes for Vertebral Artery Insufficiency

GenomeRNAi Phenotypes related to Vertebral Artery Insufficiency according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.28 LPA
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-15 9.28 PCLO
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-154 9.28 LPA PCLO
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-179 9.28 PCLO
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.28 LPA
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-211 9.28 LPA
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.28 PCLO
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.28 PCLO
9 Decreased free cholesterol GR00340-A-2 8.96 APOB LPA

Drugs & Therapeutics for Vertebral Artery Insufficiency

Search Clinical Trials , NIH Clinical Center for Vertebral Artery Insufficiency

Genetic Tests for Vertebral Artery Insufficiency

Anatomical Context for Vertebral Artery Insufficiency

MalaCards organs/tissues related to Vertebral Artery Insufficiency:

42
Spinal Cord

Publications for Vertebral Artery Insufficiency

Articles related to Vertebral Artery Insufficiency:

(show all 29)
# Title Authors Year
1
Surgical Treatment of Rotational Vertebral Artery Syndrome Induced by Spinal Tumor: A Case Report and Literature Review. ( 29018650 )
2017
2
Teaching NeuroImages: Dynamic vertebral artery insufficiency. ( 27906667 )
2016
3
A Case of Rotational Vertebral Artery Syndrome. ( 25118574 )
2016
4
Subaxial rotational vertebral artery syndrome: resection of the uncinate process and anterior fusion can be sufficient!: case report and review of the literature. ( 23429312 )
2015
5
Rotational vertebral artery syndrome. ( 22858848 )
2013
6
Rotational vertebral artery syndrome due to compression of nondominant vertebral artery terminating in posterior inferior cerebellar artery. ( 21416208 )
2011
7
Origin of isolated vertigo in rotational vertebral artery syndrome. ( 21710126 )
2011
8
Check your vestibular skills by reading about the rotational vertebral artery syndrome. ( 21948085 )
2011
9
Rotational vertebral artery syndrome: 3D kinematics of nystagmus suggest bilateral labyrinthine dysfunction. ( 18274804 )
2008
10
Rotational vertebral artery insufficiency resulting from cervical spondylosis: case report and review of the literature. ( 16720191 )
2006
11
Rotational vertebral artery syndrome: oculographic analysis of nystagmus. ( 16247059 )
2005
12
Vertebral artery insufficiency as a possible mechanism for sudden infant death--in vivo evidence does not support findings from postmortem studies. ( 12850510 )
2003
13
A possible correlation between vertebral artery insufficiency and degenerative changes in the cervical spine. ( 9833209 )
1998
14
Surgical treatment of vertebral artery insufficiency in patients with diagnosis of multiple sclerosis. ( 615387 )
1977
15
The management of vertebral artery insufficiency in cervical spondylosis: a modified technique. ( 1067075 )
1976
16
Basilar-vertebral artery insufficiency as a cause of vertigo. ( 4220283 )
1973
17
Vertebral artery insufficiency and cerebellar infarct due to manipulation of the neck. Report of a case. ( 4537897 )
1972
18
Surgical treatment of vertebral artery insufficiency caused by cervical spondylosis. ( 5438093 )
1970
19
Vertebral artery insufficiency and rotational obstruction. ( 5494812 )
1970
20
Tonal sensation as a criterion of vertebral artery insufficiency. ( 4974828 )
1969
21
Vertebral artery insufficiency secondary to trauma and osteoarthritis of the cervical spine. ( 5957375 )
1966
22
VERTEBRAL ARTERY INSUFFICIENCY PRODUCED BY CERVICAL OSTEOARTHRITIC SPURS. ( 14267666 )
1965
23
Surgical treatment of vertebral artery insufficiency caused by cervical spondylosis. ( 5861143 )
1965
24
VERTEBRAL ARTERY INSUFFICIENCY IN ACUTE CERVICAL SPINE TRAUMA. ( 14159654 )
1964
25
The surgical treatment of vertebral artery insufficiency. Successes and failures. ( 13985842 )
1963
26
VERTEBRAL ARTERY INSUFFICIENCY. ( 14063817 )
1963
27
Vertebral artery insufficiency in acute and chronic spinal trauma, with special reference to the syndrome of acute central cervical spinal cord injury. ( 13748252 )
1961
28
Vertebral artery insufficiency produced by cervical osteoarthritic spurs. ( 13711476 )
1960
29
Some neuro-ophthalmological considerations in cerebral vascular insufficiency; carotid and vertebral artery insufficiency. ( 13669806 )
1959

Variations for Vertebral Artery Insufficiency

Expression for Vertebral Artery Insufficiency

Search GEO for disease gene expression data for Vertebral Artery Insufficiency.

Pathways for Vertebral Artery Insufficiency

Pathways related to Vertebral Artery Insufficiency according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.03 APOB LPA
2 10.3 APOB LPA

GO Terms for Vertebral Artery Insufficiency

Cellular components related to Vertebral Artery Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 8.92 AARS APOB PCLO REG1A

Biological processes related to Vertebral Artery Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipid transport GO:0006869 8.96 APOB LPA
2 low-density lipoprotein particle remodeling GO:0034374 8.62 APOB LPA

Molecular functions related to Vertebral Artery Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 8.62 APOB LPA

Sources for Vertebral Artery Insufficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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