MCID: VRT003
MIFTS: 39

Vertebrobasilar Insufficiency

Categories: Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Vertebrobasilar Insufficiency

MalaCards integrated aliases for Vertebrobasilar Insufficiency:

Name: Vertebrobasilar Insufficiency 12 44 15 73
Vertebrobasilar Arterial Insufficiency 12
Vertebrobasilar Artery Syndrome 12
Vertebro-Basilar Insufficiency 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13003
ICD10 33 G45.0
ICD9CM 35 435.3
MeSH 44 D014715
SNOMED-CT 68 64009001
UMLS 73 C0042568

Summaries for Vertebrobasilar Insufficiency

MalaCards based summary : Vertebrobasilar Insufficiency, also known as vertebrobasilar arterial insufficiency, is related to subclavian steal syndrome and vertebral artery occlusion. An important gene associated with Vertebrobasilar Insufficiency is ADGRE2 (Adhesion G Protein-Coupled Receptor E2), and among its related pathways/superpathways are AGE-RAGE signaling pathway in diabetic complications and Adhesion. The drugs Paclitaxel and Albumin-Bound Paclitaxel have been mentioned in the context of this disorder. Affiliated tissues include brain, cerebellum and cortex, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 Vertebrobasilar insufficiency (VBI) or vertebral-basilar ischemia, also called beauty parlour syndrome... more...

Related Diseases for Vertebrobasilar Insufficiency

Diseases related to Vertebrobasilar Insufficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Related Disease Score Top Affiliating Genes
1 subclavian steal syndrome 11.2
2 vertebral artery occlusion 10.2
3 spondylosis 10.2
4 cyclosporiasis 10.2 GGT1 GGT2
5 lichen nitidus 10.2 C3 CHD7
6 algoneurodystrophy 10.2 GGT1 GGT2
7 periampullary adenoma 10.1 GGT1 GGT2
8 heterophyiasis 10.1 ICAM1 SELE
9 pancreatic cystadenocarcinoma 10.1 GGT1 GGT2
10 ethmoid sinus cancer 10.1 GGT1 GGT2
11 ethmoid sinus adenocarcinoma 10.1 GGT1 GGT2
12 lymphocytic vasculitis 10.1 ICAM1 SELE
13 phototoxic dermatitis 10.1 C3 ICAM1
14 mooren's ulcer 10.1 ICAM1 SELE
15 hepatic tuberculosis 10.1 GGT1 GGT2
16 shwartzman phenomenon 10.1 F3 ICAM1
17 nasal cavity disease 10.1 CHD7 ICAM1 RHNO1
18 nose disease 10.1 CHD7 ICAM1 RHNO1
19 upper respiratory tract disease 10.1 CHD7 ICAM1 RHNO1
20 hymenolepiasis 10.1 ICAM1 SELE
21 rheumatoid arthritis 10.0
22 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.0
23 arthritis 10.0
24 dementia 10.0
25 hypersensitivity reaction type iii disease 10.0 C3 ICAM1 SELE
26 bladder neck obstruction 10.0 F3 SIRPA
27 plummer's disease 10.0 ICAM1 SELE
28 narcolepsy 10.0
29 hypersomnia 10.0
30 atlantoaxial subluxation 10.0
31 cerebral falx meningioma 10.0 F3 KANTR
32 leech infestation 10.0 F3 KANTR
33 arteriosclerosis 9.9 F3 ICAM1 SELE
34 alzheimer disease 9.9
35 temporal arteritis 9.9
36 muscle hypertrophy 9.9
37 achromatopsia 9.9
38 insulinoma 9.9
39 sensorineural hearing loss 9.9
40 thoracic outlet syndrome 9.9
41 ischemia 9.9
42 radiculopathy 9.9
43 vascular dementia 9.9
44 carotid artery dissection 9.9
45 binswanger's disease 9.9
46 bow hunter's stroke 9.9
47 sudden sensorineural hearing loss 9.9
48 right aortic arch 9.9
49 actinic prurigo 9.9 ICAM1 SELE
50 sphenoid sinusitis 9.9 KANTR RHNO1

Graphical network of the top 20 diseases related to Vertebrobasilar Insufficiency:



Diseases related to Vertebrobasilar Insufficiency

Symptoms & Phenotypes for Vertebrobasilar Insufficiency

GenomeRNAi Phenotypes related to Vertebrobasilar Insufficiency according to GeneCards Suite gene sharing:

26 (show all 21)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.8 ADAMTS1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-128 9.8 GGT2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.8 GGT1 GGT2 SIRPA
4 Increased shRNA abundance (Z-score > 2) GR00366-A-131 9.8 GGT2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-143 9.8 ADAMTS1 GGT1 GGT2 SIRPA TCF20
6 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.8 SIRPA
7 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.8 ADAMTS1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.8 GGT1 TCF20
9 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.8 TCF20
10 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.8 SIRPA
11 Increased shRNA abundance (Z-score > 2) GR00366-A-208 9.8 TCF20
12 Increased shRNA abundance (Z-score > 2) GR00366-A-24 9.8 GGT2
13 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.8 TCF20
14 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.8 ADAMTS1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-51 9.8 SIRPA TCF20
16 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.8 ADAMTS1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.8 SIRPA
18 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.8 GGT1 GGT2
19 Increased shRNA abundance (Z-score > 2) GR00366-A-78 9.8 ADAMTS1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-8 9.8 TCF20
21 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.8 TCF20

MGI Mouse Phenotypes related to Vertebrobasilar Insufficiency:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.65 C3 CHD7 F3 FBXO7 GGT1 ICAM1
2 immune system MP:0005387 9.32 C3 CHD7 F3 FBXO7 GGT1 ICAM1

Drugs & Therapeutics for Vertebrobasilar Insufficiency

Drugs for Vertebrobasilar Insufficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Paclitaxel Approved, Vet_approved Phase 2, Phase 3 33069-62-4 36314
2 Albumin-Bound Paclitaxel Phase 2, Phase 3
3
Everolimus Approved Phase 2 159351-69-6 6442177
4
Sirolimus Approved, Investigational Phase 2 53123-88-9 46835353 6436030 5284616

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Drug Eluting Stents Versus Bare Metal Stents for Treatment of Symptomatic Extracranial Vertebral Artery Stenosis Completed NCT03201432 Phase 2, Phase 3
2 Prospective Evaluation of Safety and Efficacy Vertebral Drug-eluting Stent System Unknown status NCT02328781 Phase 2
3 Drug-coated Balloon Angioplasty for Patients With Symptomatic Vertebral Artery Stenosis Recruiting NCT03504657 Phase 2
4 Remote Ischemic Conditioning for Reducing Stroke Risk of Symptomatic Vertebrobasilar Lesion of Atherosclerosis Unknown status NCT02971462 Not Applicable
5 Clinical Results and Restenosis Analysis of Symptomatic Ostial Vertebral Artery Stenosis Treated With Tubular Coronary Stents Unknown status NCT00172458
6 Effects of Spinal Manipulation on Vertebrobasilar and Internal Carotis Arteries in Healthy Population Completed NCT03435159 Not Applicable
7 Vertebrobasilar Flow Evaluation and Risk of Transient Ischemic Attack and Stroke (VERiTAS) Completed NCT00590980
8 Oxygen Concentration and Recovery After Carotid Endarterectomy Completed NCT02991976 Not Applicable
9 Differential Diagnosis for the Causes of Subclavian Steal for Patients With Vascular Access in the Forearm Completed NCT01263301 Not Applicable
10 Vertebrobasilar Flow Evaluation and Risk of Transient Ischemic Attack and Stroke II Not yet recruiting NCT03729817 Not Applicable

Search NIH Clinical Center for Vertebrobasilar Insufficiency

Cochrane evidence based reviews: vertebrobasilar insufficiency

Genetic Tests for Vertebrobasilar Insufficiency

Anatomical Context for Vertebrobasilar Insufficiency

MalaCards organs/tissues related to Vertebrobasilar Insufficiency:

41
Brain, Cerebellum, Cortex, Thalamus, Pons, Testes, Pancreas

Publications for Vertebrobasilar Insufficiency

Articles related to Vertebrobasilar Insufficiency:

(show top 50) (show all 136)
# Title Authors Year
1
Vertebrobasilar Insufficiency ( 29489229 )
2018
2
Emergency Superficial Temporal Artery-Superior Cerebellar Artery Bypass for the Refractory Vertebrobasilar Insufficiency with Partial Mastoidectomy. ( 30010066 )
2018
3
Vertebrobasilar Insufficiency Due to Distal Posterior Inferior Cerebellar Artery Compression in Chiari 1.5. ( 28583457 )
2017
4
Congenital Bilateral C2 Transverse Foramina Stenosis Causing Adult-Onset Vertebrobasilar Insufficiency and Posterior Circulation Stroke. ( 28626412 )
2017
5
Subclavian-to-Extracranial Vertebral Artery Bypass in a Patient With Vertebrobasilar Insufficiency: 3-Dimensional Operative Video. ( 28973539 )
2017
6
The association between vertebrobasilar insufficiency and the risk of dementia: a nationwide register-based retrospective cohort study in Taiwan. ( 28838901 )
2017
7
Acupuncture for vertebrobasilar insufficiency vertigo: Protocol for a systematic review and meta-analysis. ( 29390369 )
2017
8
The effect of chinese herbal medicine Banxia Baizhu Tianma Decoction for the treatment of vertebrobasilar insufficiency vertigo: A systematic review and meta-analysis of randomized controlled trials. ( 28434468 )
2017
9
Treatment of vertebrobasilar insufficiency due to stenosis and aneurysm of the vertebral artery. ( 28594803 )
2017
10
Occipital Artery to Anterior Inferior Cerebellar Artery Bypass with Radial Artery Interposition Graft for Vertebrobasilar Insufficiency: 3-Dimensional Operative Video. ( 28922887 )
2017
11
Pathophysiology and Diagnosis of Vertebrobasilar Insufficiency: A Review of the Literature. ( 28680502 )
2017
12
Vertebrobasilar insufficiency and gamma-glutamyltransferase: An emerging relationship demonstrating inflammation and atherosclerosis. ( 27546696 )
2016
13
Association of Sudden Sensorineural Hearing Loss With Vertebrobasilar Insufficiency. ( 27195937 )
2016
14
Rotational vertebrobasilar insufficiency due to compression of a persistent first intersegmental vertebral artery variant: case report. ( 27716015 )
2016
15
Radial Artery Bypass for Intractable Vertebrobasilar Insufficiency: Case Series and Review of the Literature. ( 26284960 )
2015
16
Are there any novel radiological diagnostic clues in magnetic resonance imaging for vertebrobasilar insufficiency? ( 26807367 )
2015
17
Clinical research of persimmon leaf extract and ginkgo biloba extract in the treatment of vertebrobasilar insufficiency. ( 25864752 )
2015
18
The comparative analyses of the auditory evoked potentials and color Doppler sonography findings in patients diagnosed with vertebrobasilar insufficiency. ( 24806547 )
2014
19
Insulinoma clinically misdiagnosed as vertebrobasilar insufficiency in an obese patient with recurrent episodes of loss of consciousness. ( 25062882 )
2014
20
Low scores on the Benton Facial Recognition Test associated with vertebrobasilar insufficiency. ( 23474072 )
2013
21
Diagnostic accuracy of premanipulative vertebrobasilar insufficiency tests: a systematic review. ( 23127991 )
2013
22
The effect of prostaglandin E1 on brainstem blood flow disturbance in an animal model of vertebrobasilar insufficiency. ( 23591797 )
2013
23
Diagnosis and management of vertebrobasilar insufficiency. ( 23378181 )
2013
24
Bow hunter's syndrome causing vertebrobasilar insufficiency in a young male with neck muscle hypertrophy: a case report and literature review. ( 24184499 )
2013
25
Cervical spondylosis: a rare and curable cause of vertebrobasilar insufficiency. ( 24000075 )
2013
26
The diagnosis of vertebrobasilar insufficiency using transcranial Doppler ultrasound. ( 23251187 )
2012
27
Evaluation of patients with vertigo of vertebrobasilar insufficiency origin using auditory brainstem response, electronystagmography, and transcranial Doppler. ( 22299665 )
2012
28
Isolated sudden hearing loss as a warning sign of vertebrobasilar insufficiency. ( 22892808 )
2012
29
The impact of laser irradiation on global stability in patients with vertebrobasilar insufficiency: a clinical report. ( 21873949 )
2011
30
The clinical reasoning of musculoskeletal physiotherapists in relation to the assessment of vertebrobasilar insufficiency: a qualitative study. ( 20381404 )
2010
31
Vertebrobasilar insufficiency due to right aortic arch with isolation of the left subclavian artery. ( 19198039 )
2009
32
Vertebrobasilar insufficiency presenting as isolated positional vertigo or dizziness: a double-blind retrospective cohort study. ( 19688845 )
2009
33
Giant cell arteritis revealed by vertebrobasilar insufficiency. ( 19208584 )
2009
34
Carotid artery dissection and vertebrobasilar insufficiency. ( 19584618 )
2009
35
Positional vertebral artery compression and vertebrobasilar insufficiency due to a herniated cervical disc. ( 19769514 )
2009
36
Surgical management of vertebrobasilar insufficiency due to pathology of the second-third segments of the vertebral artery. ( 20394339 )
2009
37
Multichannel computed tomography angiography and its role in the evaluation of rotational vertebrobasilar insufficiency. ( 18303305 )
2008
38
Forty-six cases of vertebrobasilar insufficiency treated by acupuncture plus intravenous infusion of ligustrazine. ( 19226890 )
2008
39
Is mechanical deformation of the suboccipital vertebral artery during cervical spine rotation responsible for vertebrobasilar insufficiency? ( 17624896 )
2008
40
Correlations of arterial hemodynamics with the severity of clinical manifestations of vertebrobasilar insufficiency. ( 19489320 )
2008
41
Rotational vertebrobasilar insufficiency due to dynamic compression of the dominant vertebral artery by the thyroid cartilage and occlusion of the contralateral vertebral artery at C1-2 level. ( 18298678 )
2008
42
Treatment of vertebrobasilar insufficiency--associated vertigo with a fixed combination of cinnarizine and dimenhydrinate. ( 18616088 )
2008
43
"Stretched loop sign" of the vertebral artery: a predictor of vertebrobasilar insufficiency in atlantoaxial dislocation. ( 16935639 )
2006
44
Endovascular treatment of supra-aortic extracranial stenoses in patients with vertebrobasilar insufficiency symptoms. ( 16718428 )
2006
45
Vertebrobasilar insufficiency. ( 16533485 )
2006
46
Comparison of vertebral artery velocity and flow volume measurements for diagnosis of vertebrobasilar insufficiency using color duplex sonography. ( 15837402 )
2005
47
Screening for vertebrobasilar insufficiency in patients with neck pain: manual therapy decision-making in the presence of uncertainty. ( 15966541 )
2005
48
Reactivity of rat basilar artery to serotonin after short-term ischemia of hindbrain and during chronic vertebrobasilar insufficiency. ( 16027866 )
2005
49
The role of SPECT imaging in the diagnosis of vertebrobasilar insufficiency. ( 15753788 )
2005
50
Clinical diagnosis of vertebrobasilar insufficiency: resident's case problem. ( 16294985 )
2005

Variations for Vertebrobasilar Insufficiency

Expression for Vertebrobasilar Insufficiency

Search GEO for disease gene expression data for Vertebrobasilar Insufficiency.

Pathways for Vertebrobasilar Insufficiency

Pathways related to Vertebrobasilar Insufficiency according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.13 F3 ICAM1 SELE
2 11.01 ADAMTS1 F3 ICAM1 SIRPA
3 10.64 GGT1 GGT2
4 10.52 GGT1 GGT2

GO Terms for Vertebrobasilar Insufficiency

Biological processes related to Vertebrobasilar Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of inflammatory response GO:0050727 9.54 GGT1 GGT2 SELE
2 glutamate metabolic process GO:0006536 9.48 GGT1 GGT2
3 zymogen activation GO:0031638 9.46 GGT1 GGT2
4 response to lipopolysaccharide GO:0032496 9.46 GGT1 GGT2 ICAM1 SELE
5 glutathione catabolic process GO:0006751 9.43 GGT1 GGT2
6 leukotriene D4 biosynthetic process GO:1901750 9.4 GGT1 GGT2
7 cysteine biosynthetic process GO:0019344 9.32 GGT1 GGT2
8 regulation of immune system process GO:0002682 9.26 GGT1 GGT2
9 peptide modification GO:0031179 8.96 GGT1 GGT2
10 response to tumor necrosis factor GO:0034612 8.8 GGT1 GGT2 SELE

Molecular functions related to Vertebrobasilar Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glutathione hydrolase activity GO:0036374 8.96 GGT1 GGT2
2 peptidyltransferase activity GO:0000048 8.62 GGT1 GGT2

Sources for Vertebrobasilar Insufficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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