MCID: VRT003
MIFTS: 32

Vertebrobasilar Insufficiency

Categories: Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Vertebrobasilar Insufficiency

MalaCards integrated aliases for Vertebrobasilar Insufficiency:

Name: Vertebrobasilar Insufficiency 12 45 15 17 74
Vertebrobasilar Arterial Insufficiency 12
Vertebrobasilar Artery Syndrome 12
Vertebro-Basilar Insufficiency 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13003
ICD9CM 36 435.3
MeSH 45 D014715
SNOMED-CT 69 64009001
ICD10 34 G45.0
UMLS 74 C0042568

Summaries for Vertebrobasilar Insufficiency

MalaCards based summary : Vertebrobasilar Insufficiency, also known as vertebrobasilar arterial insufficiency, is related to subclavian steal syndrome and carotid stenosis. An important gene associated with Vertebrobasilar Insufficiency is ADGRE2 (Adhesion G Protein-Coupled Receptor E2). The drugs Paclitaxel and Albumin-Bound Paclitaxel have been mentioned in the context of this disorder. Affiliated tissues include brain, cerebellum and cortex, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 77 Vertebrobasilar insufficiency (VBI) or vertebral-basilar ischemia, also called beauty parlour syndrome... more...

Related Diseases for Vertebrobasilar Insufficiency

Graphical network of the top 20 diseases related to Vertebrobasilar Insufficiency:



Diseases related to Vertebrobasilar Insufficiency

Symptoms & Phenotypes for Vertebrobasilar Insufficiency

GenomeRNAi Phenotypes related to Vertebrobasilar Insufficiency according to GeneCards Suite gene sharing:

27 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.77 SIRPA
2 Increased shRNA abundance (Z-score > 2) GR00366-A-143 9.77 SIRPA TCF20
3 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.77 SIRPA
4 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.77 TCF20
5 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.77 TCF20
6 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.77 SIRPA
7 Increased shRNA abundance (Z-score > 2) GR00366-A-208 9.77 TCF20
8 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.77 TCF20
9 Increased shRNA abundance (Z-score > 2) GR00366-A-51 9.77 SIRPA TCF20
10 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.77 SIRPA
11 Increased shRNA abundance (Z-score > 2) GR00366-A-8 9.77 TCF20
12 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.77 TCF20

Drugs & Therapeutics for Vertebrobasilar Insufficiency

Drugs for Vertebrobasilar Insufficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Paclitaxel Approved, Vet_approved Phase 2, Phase 3 33069-62-4 36314
2 Albumin-Bound Paclitaxel Phase 2, Phase 3
3
Everolimus Approved Phase 2,Not Applicable 159351-69-6 70789204 6442177
4
Sirolimus Approved, Investigational Phase 2,Not Applicable 53123-88-9 46835353 5284616 6436030
5
Miconazole Approved, Investigational, Vet_approved Not Applicable 22916-47-8 4189
6 Antibiotics, Antitubercular Not Applicable
7 Anti-Bacterial Agents Not Applicable
8 Anti-Infective Agents Not Applicable
9 Antifungal Agents Not Applicable
10 Immunologic Factors Not Applicable
11 Immunosuppressive Agents Not Applicable

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Drug Eluting Stents Versus Bare Metal Stents for Treatment of Symptomatic Extracranial Vertebral Artery Stenosis Completed NCT03201432 Phase 2, Phase 3
2 Prospective Evaluation of Safety and Efficacy Vertebral Drug-eluting Stent System Unknown status NCT02328781 Phase 2
3 Drug-coated Balloon Angioplasty for Patients With Symptomatic Vertebral Artery Stenosis Recruiting NCT03504657 Phase 2
4 Remote Ischemic Conditioning for Reducing Stroke Risk of Symptomatic Vertebrobasilar Lesion of Atherosclerosis Unknown status NCT02971462 Not Applicable
5 Clinical Results and Restenosis Analysis of Symptomatic Ostial Vertebral Artery Stenosis Treated With Tubular Coronary Stents Unknown status NCT00172458
6 Effects of Spinal Manipulation on Vertebrobasilar and Internal Carotis Arteries in Healthy Population Completed NCT03435159 Not Applicable
7 Vertebrobasilar Flow Evaluation and Risk of Transient Ischemic Attack and Stroke (VERiTAS) Completed NCT00590980
8 Firehorus Rapamycin Target Eluting Vertebral Artery Stent System in Clinical Application Completed NCT03859674 Not Applicable
9 Oxygen Concentration and Recovery After Carotid Endarterectomy Completed NCT02991976 Not Applicable
10 Differential Diagnosis for the Causes of Subclavian Steal for Patients With Vascular Access in the Forearm Completed NCT01263301 Not Applicable
11 Vertebrobasilar Flow Evaluation and Risk of Transient Ischemic Attack and Stroke II Not yet recruiting NCT03729817 Not Applicable

Search NIH Clinical Center for Vertebrobasilar Insufficiency

Cochrane evidence based reviews: vertebrobasilar insufficiency

Genetic Tests for Vertebrobasilar Insufficiency

Anatomical Context for Vertebrobasilar Insufficiency

MalaCards organs/tissues related to Vertebrobasilar Insufficiency:

42
Brain, Cerebellum, Cortex, Pons, Thalamus, Testes, Thyroid

Publications for Vertebrobasilar Insufficiency

Articles related to Vertebrobasilar Insufficiency:

(show top 50) (show all 137)
# Title Authors Year
1
Carotid-vertebral artery bypass with saphenous vein graft for symptomatic vertebrobasilar insufficiency. ( 30717073 )
2019
2
Extracranial-to-intracranial bypass for refractory vertebrobasilar insufficiency. ( 30926554 )
2019
3
Subclavian-to-Extracranial Vertebral Artery Bypass in a Patient With Vertebrobasilar Insufficiency: 3-Dimensional Operative Video. ( 28973539 )
2018
4
Emergency Superficial Temporal Artery-Superior Cerebellar Artery Bypass for the Refractory Vertebrobasilar Insufficiency with Partial Mastoidectomy. ( 30010066 )
2018
5
Rotational vertebrobasilar insufficiency due to compression of a persistent first intersegmental vertebral artery variant: case report. ( 27716015 )
2017
6
The effect of chinese herbal medicine Banxia Baizhu Tianma Decoction for the treatment of vertebrobasilar insufficiency vertigo: A systematic review and meta-analysis of randomized controlled trials. ( 28434468 )
2017
7
Vertebrobasilar Insufficiency Due to Distal Posterior Inferior Cerebellar Artery Compression in Chiari 1.5. ( 28583457 )
2017
8
Treatment of vertebrobasilar insufficiency due to stenosis and aneurysm of the vertebral artery. ( 28594803 )
2017
9
Congenital Bilateral C2 Transverse Foramina Stenosis Causing Adult-Onset Vertebrobasilar Insufficiency and Posterior Circulation Stroke. ( 28626412 )
2017
10
Pathophysiology and Diagnosis of Vertebrobasilar Insufficiency: A Review of the Literature. ( 28680502 )
2017
11
The association between vertebrobasilar insufficiency and the risk of dementia: a nationwide register-based retrospective cohort study in Taiwan. ( 28838901 )
2017
12
Occipital Artery to Anterior Inferior Cerebellar Artery Bypass with Radial Artery Interposition Graft for Vertebrobasilar Insufficiency: 3-Dimensional Operative Video. ( 28922887 )
2017
13
Acupuncture for vertebrobasilar insufficiency vertigo: Protocol for a systematic review and meta-analysis. ( 29390369 )
2017
14
Association of Sudden Sensorineural Hearing Loss With Vertebrobasilar Insufficiency. ( 27195937 )
2016
15
Radial Artery Bypass for Intractable Vertebrobasilar Insufficiency: Case Series and Review of the Literature. ( 26284960 )
2016
16
Vertebrobasilar insufficiency and gamma-glutamyltransferase: An emerging relationship demonstrating inflammation and atherosclerosis. ( 27546696 )
2016
17
Clinical research of persimmon leaf extract and ginkgo biloba extract in the treatment of vertebrobasilar insufficiency. ( 25864752 )
2015
18
Are there any novel radiological diagnostic clues in magnetic resonance imaging for vertebrobasilar insufficiency? ( 26807367 )
2015
19
Insulinoma clinically misdiagnosed as vertebrobasilar insufficiency in an obese patient with recurrent episodes of loss of consciousness. ( 25062882 )
2014
20
Bow hunter's syndrome causing vertebrobasilar insufficiency in a young man with neck muscle hypertrophy. ( 24184499 )
2014
21
Cervical spondylosis: a rare and curable cause of vertebrobasilar insufficiency. ( 24000075 )
2014
22
The effect of prostaglandin E1 on brainstem blood flow disturbance in an animal model of vertebrobasilar insufficiency. ( 23591797 )
2014
23
The comparative analyses of the auditory evoked potentials and color Doppler sonography findings in patients diagnosed with vertebrobasilar insufficiency. ( 24806547 )
2014
24
Diagnostic accuracy of premanipulative vertebrobasilar insufficiency tests: a systematic review. ( 23127991 )
2013
25
Diagnosis and management of vertebrobasilar insufficiency. ( 23378181 )
2013
26
Low scores on the Benton Facial Recognition Test associated with vertebrobasilar insufficiency. ( 23474072 )
2013
27
Evaluation of patients with vertigo of vertebrobasilar insufficiency origin using auditory brainstem response, electronystagmography, and transcranial Doppler. ( 22299665 )
2012
28
Isolated sudden hearing loss as a warning sign of vertebrobasilar insufficiency. ( 22892808 )
2012
29
The diagnosis of vertebrobasilar insufficiency using transcranial Doppler ultrasound. ( 23251187 )
2012
30
The impact of laser irradiation on global stability in patients with vertebrobasilar insufficiency: a clinical report. ( 21873949 )
2011
31
The clinical reasoning of musculoskeletal physiotherapists in relation to the assessment of vertebrobasilar insufficiency: a qualitative study. ( 20381404 )
2010
32
Carotid artery dissection and vertebrobasilar insufficiency. ( 19584618 )
2009
33
Vertebrobasilar insufficiency due to right aortic arch with isolation of the left subclavian artery. ( 19198039 )
2009
34
Giant cell arteritis revealed by vertebrobasilar insufficiency. ( 19208584 )
2009
35
Vertebrobasilar insufficiency presenting as isolated positional vertigo or dizziness: a double-blind retrospective cohort study. ( 19688845 )
2009
36
Positional vertebral artery compression and vertebrobasilar insufficiency due to a herniated cervical disc. ( 19769514 )
2009
37
Surgical management of vertebrobasilar insufficiency due to pathology of the second-third segments of the vertebral artery. ( 20394339 )
2009
38
Is mechanical deformation of the suboccipital vertebral artery during cervical spine rotation responsible for vertebrobasilar insufficiency? ( 17624896 )
2008
39
Rotational vertebrobasilar insufficiency due to dynamic compression of the dominant vertebral artery by the thyroid cartilage and occlusion of the contralateral vertebral artery at C1-2 level. ( 18298678 )
2008
40
Multichannel computed tomography angiography and its role in the evaluation of rotational vertebrobasilar insufficiency. ( 18303305 )
2008
41
Treatment of vertebrobasilar insufficiency--associated vertigo with a fixed combination of cinnarizine and dimenhydrinate. ( 18616088 )
2008
42
Forty-six cases of vertebrobasilar insufficiency treated by acupuncture plus intravenous infusion of ligustrazine. ( 19226890 )
2008
43
Correlations of arterial hemodynamics with the severity of clinical manifestations of vertebrobasilar insufficiency. ( 19489320 )
2008
44
Vertebrobasilar insufficiency. ( 16533485 )
2006
45
Endovascular treatment of supra-aortic extracranial stenoses in patients with vertebrobasilar insufficiency symptoms. ( 16718428 )
2006
46
"Stretched loop sign" of the vertebral artery: a predictor of vertebrobasilar insufficiency in atlantoaxial dislocation. ( 16935639 )
2006
47
The role of SPECT imaging in the diagnosis of vertebrobasilar insufficiency. ( 15753788 )
2005
48
Comparison of vertebral artery velocity and flow volume measurements for diagnosis of vertebrobasilar insufficiency using color duplex sonography. ( 15837402 )
2005
49
Screening for vertebrobasilar insufficiency in patients with neck pain: manual therapy decision-making in the presence of uncertainty. ( 15966541 )
2005
50
Reactivity of rat basilar artery to serotonin after short-term ischemia of hindbrain and during chronic vertebrobasilar insufficiency. ( 16027866 )
2005

Variations for Vertebrobasilar Insufficiency

Expression for Vertebrobasilar Insufficiency

Search GEO for disease gene expression data for Vertebrobasilar Insufficiency.

Pathways for Vertebrobasilar Insufficiency

GO Terms for Vertebrobasilar Insufficiency

Biological processes related to Vertebrobasilar Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell migration GO:0016477 8.62 ADGRE2 SIRPA

Sources for Vertebrobasilar Insufficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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