BRV
MCID: VRT013
MIFTS: 37

Vertigo, Benign Recurrent (BRV)

Categories: Genetic diseases

Aliases & Classifications for Vertigo, Benign Recurrent

MalaCards integrated aliases for Vertigo, Benign Recurrent:

Name: Vertigo, Benign Recurrent 57
Vertigo, Benign Paroxysmal Positional 57 13
Vertigo, Benign Paroxysmal Positional; Bppv 57
Benign Paroxysmal Positional Vertigo 73
Vestibulopathy, Familial 57
Bppv 57
Brv 57

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant

Miscellaneous:
slowly progressive disorder
acetazolamide may benefit attacks of vertigo


HPO:

32
vertigo, benign recurrent:
Onset and clinical course slow progression
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 57 193007
MedGen 42 C0155502
UMLS 73 C0155502

Summaries for Vertigo, Benign Recurrent

OMIM : 57 Benign recurrent vertigo (BRV), also known as benign paroxysmal positional vertigo (BPPV), is a common disorder affecting up to 2% of the adult population. The majority of individuals with chronic recurrent vertigo have no identifiable cause, no progression of the disorder, and no other neurologic or auditory signs. Many families have multiple affected individuals, suggesting familial transmission of the disorder with moderate to high penetrance (summary by Lee et al., 2006). (193007)

MalaCards based summary : Vertigo, Benign Recurrent, also known as vertigo, benign paroxysmal positional, is related to vertigo, benign recurrent, 2 and benign paroxysmal positional nystagmus, and has symptoms including vertigo, vertigo/dizziness and cupulolithiasis. An important gene associated with Vertigo, Benign Recurrent is BRV2 (Vertigo, Benign Recurrent, 2). The drugs Calcium Carbonate and Vitamin D3 have been mentioned in the context of this disorder. Affiliated tissues include testes, bone and brain, and related phenotypes are gait imbalance and vertigo

Related Diseases for Vertigo, Benign Recurrent

Graphical network of the top 20 diseases related to Vertigo, Benign Recurrent:



Diseases related to Vertigo, Benign Recurrent

Symptoms & Phenotypes for Vertigo, Benign Recurrent

Symptoms via clinical synopsis from OMIM:

57
Neurologic Central Nervous System:
gait imbalance
vertigo, episodic (onset in second or third decade)
vestibulopathy, bilateral, progressive (onset in fourth or fifth decade)
oscillopsia

Head And Neck Ears:
vertigo, episodic
vestibulopathy, bilateral, progressive
no hearing loss


Clinical features from OMIM:

193007

Human phenotypes related to Vertigo, Benign Recurrent:

32
# Description HPO Frequency HPO Source Accession
1 gait imbalance 32 HP:0002141
2 vertigo 32 HP:0002321

UMLS symptoms related to Vertigo, Benign Recurrent:


vertigo, vertigo/dizziness, cupulolithiasis

Drugs & Therapeutics for Vertigo, Benign Recurrent

Drugs for Vertigo, Benign Recurrent (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 49)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Calcium Carbonate Approved, Investigational Phase 4 471-34-1
2
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 5280795 6221
3
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
4
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
5 Calcium Supplement Phase 4
6 Anti-Ulcer Agents Phase 4
7 Calciferol Phase 4
8 Micronutrients Phase 4
9 Calcium, Dietary Phase 4
10 Ergocalciferols Phase 4
11 Gastrointestinal Agents Phase 4,Not Applicable
12 Vitamin D2 Phase 4
13 Antacids Phase 4
14 Trace Elements Phase 4
15 Vitamins Phase 4
16 Bone Density Conservation Agents Phase 4
17
Lorazepam Approved Not Applicable 846-49-1 3958
18
Promethazine Approved, Investigational Not Applicable 60-87-7 4927
19
Histamine Approved, Investigational Not Applicable 51-45-6, 75614-87-8 774
20
Diphenhydramine Approved, Investigational Not Applicable 147-24-0, 58-73-1 3100
21
Ondansetron Approved Not Applicable 99614-02-5 4595
22
Diazepam Approved, Illicit, Investigational, Vet_approved Not Applicable 439-14-5 3016
23
Meclizine Approved Not Applicable 569-65-3 4034
24
Betahistine Approved, Investigational Not Applicable 5638-76-6 2366
25
Histamine Phosphate Not Applicable 51-74-1 65513
26 Peripheral Nervous System Agents Not Applicable
27 Serotonin Agents Not Applicable
28 Psychotropic Drugs Not Applicable
29 Serotonin Antagonists Not Applicable
30 Anti-Allergic Agents Not Applicable
31 Histamine Antagonists Not Applicable
32 Hypnotics and Sedatives Not Applicable
33 Antipsychotic Agents Not Applicable
34 Anesthetics Not Applicable
35 Anesthetics, Local Not Applicable
36 Dermatologic Agents Not Applicable
37 Central Nervous System Depressants Not Applicable
38 Anticonvulsants Not Applicable
39 Autonomic Agents Not Applicable
40 Tranquilizing Agents Not Applicable
41 Antiemetics Not Applicable
42 Anti-Anxiety Agents Not Applicable
43 GABA Agents Not Applicable
44 GABA Modulators Not Applicable
45 Neurotransmitter Agents Not Applicable
46 Antipruritics Not Applicable
47 Histamine H1 Antagonists Not Applicable
48 Vasodilator Agents Not Applicable
49
Serotonin Investigational, Nutraceutical Not Applicable 50-67-9 5202

Interventional clinical trials:

(show all 33)
# Name Status NCT ID Phase Drugs
1 Efficacy of Vitamin D and Calcium Supplementation on the Prevention of Recurrences in BPPV Completed NCT02031692 Phase 4 400IU cholecalciferol and 500mg of elemental calcium as calcium carbonate
2 The Treatment of Posterior Semicircular Canal Benign Paroxysmal Positional Vertigo Completed NCT02029508 Phase 3
3 Treatment of Geotropic Horizontal Canal Benign Paroxysmal Positional Vertigo Completed NCT01366430 Phase 3
4 Treatment of Apogeotropic Horizontal Canal Benign Paroxysmal Positional Vertigo Completed NCT00810641 Phase 3
5 Canalith Repositioning Procedure for BPPV in Primary Care Completed NCT00182273 Phase 3
6 Visual Feedback Goggle for Positional Vertigo Treatment Unknown status NCT00729885 Phase 1, Phase 2
7 Treatment of Apogeotropic Horizontal Canal Benign Paroxysmal Positional Vertigo Completed NCT02046980 Phase 2
8 Treatments for Benign Paroxysmal Positional Vertigo (BPPV) Completed NCT00000359 Phase 2
9 Efficacy of Postural Restriction in Treating Benign Paroxysmal Positional Vertigo Unknown status NCT02475239 Not Applicable
10 Treatment of Posterior Canal Type of Benign Paroxysmal Positional Vertigo Unknown status NCT01822002 Not Applicable
11 The Liberatory Maneuver for the Treatment of Benign Paroxysmal Positional Vertigo (BPPV) Unknown status NCT01008124 Not Applicable
12 Comparison of Home-Based Exercise on the Posterior Canal Benign Paroxysmal Positional Vertigo Symptoms Completed NCT03230513 Not Applicable
13 Evidence Based Best Care Practice for Benign Paroxysmal Positional Vertigo Completed NCT02809599 Not Applicable
14 Treating Benign Paroxysmal Positional Vertigo (BPPV) in ED Patients Completed NCT00641797 Not Applicable Meclizine;Lorazepam;Diphenhydramine;Ondansetron
15 Vestibular Evoked Myogenic Potentials in Benign Paroxysmal Positional Vertigo (VEMP in BPPV) Completed NCT01004913
16 BPPV Treatment in Biaxial Rotational Chair Completed NCT01905800 Not Applicable
17 Clinical Aspects of Patients With Benign Paroxysmal Positional Vertigo (BPPV) and Migraine Completed NCT02615314
18 Effectiveness of the Epley Manoeuvre Performed in Primary Care to Treat Benign Paroxysmal Positional Vertigo Completed NCT01969513 Not Applicable
19 Effectiveness of Osteopathic Manipulative Treatment (OMT) and Vestibular Rehabilitation Therapy (VRT) in Individuals With Vertigo Completed NCT01529151 Not Applicable
20 To Study the Characteristics of Different Types of Vertigo in Patients Attending the Ear Nose & Throat (ENT) Clinics. Completed NCT02213120
21 Osteotome Sinus Floor Elevation With or Without Grafting Completed NCT01619956 Not Applicable
22 Sinus Lift: Saving Time and Reducing Morbidity Completed NCT02415946 Not Applicable
23 Different Treatments With the TRV Reposition Chair Recruiting NCT03541018 Not Applicable
24 BPPV With CRP: Single Versus Multiple Cycles Recruiting NCT02701218 Not Applicable
25 Inactivity, Balance Problems and Fall Risk in Institutionalized Frail Elderly Recruiting NCT02905292
26 Interventions for Residual Dizziness After Successful Repositioning Maneuvers in Patients With BPPV Recruiting NCT03624283 Not Applicable Betahistine
27 3D Model of Posterior Membranous Labyrinth of the Inner Ear Recruiting NCT03295929
28 Acute Video-oculography for Vertigo in Emergency Rooms for Rapid Triage (AVERT) Recruiting NCT02483429 Not Applicable
29 Clinical Evaluation of Two Types of Transalveolar Sinus Floor Elevation Recruiting NCT03445039 Not Applicable
30 Efficacy of a Mechanical Chair for Treatment of Benign Paroxysmal Positional Vertigo (BPPV) Enrolling by invitation NCT03161470 Not Applicable
31 Benign Paroxysmal Positional Vertigo (BPPV) Training for Sports Medicine Providers in a Pediatric Concussion Program Not yet recruiting NCT03425786 Not Applicable
32 Evaluation of the Prevalence of BPPV and Longterm Effects of Its Therapy Using the Rotundum Device in Retirement Homes Not yet recruiting NCT03643354 Not Applicable
33 Effects of Physical Treatment on Postural Stability in Benign Paroxysmal Positional Vertigo (BPPV) Patients Withdrawn NCT00978809 Not Applicable

Search NIH Clinical Center for Vertigo, Benign Recurrent

Genetic Tests for Vertigo, Benign Recurrent

Anatomical Context for Vertigo, Benign Recurrent

MalaCards organs/tissues related to Vertigo, Benign Recurrent:

41
Testes, Bone, Brain, Thyroid, Spinal Cord, Cerebellum

Publications for Vertigo, Benign Recurrent

Articles related to Vertigo, Benign Recurrent:

(show top 50) (show all 825)
# Title Authors Year
1
Benign paroxysmal positional vertigo in children. ( 30220115 )
2019
2
Reduction of bone mineral density in native Chinese female idiopathic benign paroxysmal positional vertigo patients. ( 29042068 )
2018
3
Benign paroxysmal positional vertigo in patients after mild traumatic brain injury. ( 30058780 )
2018
4
Fourth ventricle ependymoma mimicking benign paroxysmal positional vertigo. ( 30104227 )
2018
5
Benign paroxysmal positional vertigo in spontaneous intracranial hypotension. ( 30052143 )
2018
6
Subjective benign paroxysmal positional vertigo in patients with osteoporosis or migraine. ( 30482521 )
2018
7
Osteoporosis increases the risk of benign paroxysmal positional vertigo: a nested case-control study using a national sample cohort. ( 30511104 )
2018
8
Benign paroxysmal positional vertigo and osteoporosis. ( 30554357 )
2018
9
The prevalence of benign paroxysmal positional vertigo in patients with osteoporosis. ( 30315360 )
2018
10
Idiopathic benign paroxysmal positional vertigo with persistent vertigo/dizziness sensation is associated with latent canal paresis, endolymphatic hydrops, and osteoporosis. ( 30042018 )
2018
11
Teaching Patient-Centered Counseling Skills for Assessment, Diagnosis, and Management of Benign Paroxysmal Positional Vertigo. ( 29422713 )
2018
12
Successful management of benign paroxysmal positional vertigo (BPPV) in a patient who was ventilated with a C3 complete spinal injury on a regional spinal unit intensive care. ( 29437815 )
2018
13
Analysis of effect of 1α-hydroxyvitamin D3 on benign paroxysmal positional vertigo and risk factors. ( 29456639 )
2018
14
Utility of the bow and lean test in predicting subtype of benign paroxysmal positional vertigo. ( 29481705 )
2018
15
Analysis of non-posterior canal benign paroxysmal positional vertigo in patients treated using the particle repositioning chair: A large, single-institution series. ( 29544670 )
2018
16
The aVOR App Increases Medical Students' Competence in Treating Benign Paroxysmal Positional Vertigo (BPPV). ( 29579015 )
2018
17
Presence of Anxiety and Depression Symptoms Affects the First Time Treatment Efficacy and Recurrence of Benign Paroxysmal Positional Vertigo. ( 29619005 )
2018
18
Recurrence in Benign Paroxysmal Positional Vertigo: A Large, Single-Institution Study. ( 29649052 )
2018
19
The Necessity for Post-Maneuver Restrictions in the Treatment of Benign Paroxysmal Positional Vertigo: An Updated Meta-Analysis of the Literature. ( 29697583 )
2018
20
Treatment of Patients With Benign Paroxysmal Positional Vertigo and Severe Immobility Using the Particle Repositioning Chair: A Retrospective Cohort Study. ( 29732909 )
2018
21
Fracture probability assessed using FRAX® in elderly women with benign paroxysmal positional vertigo. ( 29784241 )
2018
22
Incidence and Clinical Significance of Positional Downbeat Nystagmus in Posterior Canal Benign Paroxysmal Positional Vertigo. ( 29856161 )
2018
23
Benign Paroxysmal Positional Vertigo After Piezosurgical Removal of Osseointegrated Implants. ( 29877981 )
2018
24
Assessment of sleep quality in benign paroxysmal positional vertigo recurrence. ( 29883234 )
2018
25
Otolithic damage study in patients with benign paroxysmal positional vertigo with vestibular evoked myogenic potentials. ( 29895391 )
2018
26
Comparison of automatic and manual reposition treatment for horizontal semicircular canal benign paroxysmal positional vertigo. ( 29921405 )
2018
27
Efficacy of SRM-IV Vestibular Function Diagnosis and Treatment System in Treating Benign Paroxysmal Positional Vertigo. ( 29922605 )
2018
28
Efficacy of Repositioning Therapy in Patients With Benign Paroxysmal Positional Vertigo and Preexisting Central Neurologic Disorders. ( 30013505 )
2018
29
The Effects of the Vestibular Rehabilitation on the Benign Paroxysmal Positional Vertigo Recurrence Rate in Patients with Otolith Dysfunction. ( 30016856 )
2018
30
Patient, disease, and outcome characteristics of benign paroxysmal positional vertigo with and without Meniere's disease. ( 30016894 )
2018
31
Comparison of the effectiveness of Brandt-Daroff Vestibular training and Epley Canalith repositioning maneuver in benign Paroxysmal positional vertigo long term result: A randomized prospective clinical trial. ( 30034415 )
2018
32
Anxiety, Mood, and Personality Disorders in Patients with Benign Paroxysmal Positional Vertigo. ( 30042641 )
2018
33
Therapeutic efficacy of the Galletti-Contrino manoeuvre for benign paroxysmal positional vertigo of vertical semicircular canals in overweight subjects. ( 30097716 )
2018
34
Spontaneous Canalith Jam and Apogeotropic Horizontal Canal Benign Paroxysmal Positional Vertigo: Considerations on a Particular Case Mimicking an Acute Vestibular Deficit. ( 30106853 )
2018
35
Assessment of Physician Adherence to Guidelines for the Diagnosis and Treatment of Benign Paroxysmal Positional Vertigo in Ambulatory Care Settings. ( 30128474 )
2018
36
Asking about dizziness when turning in bed predicts examination findings for benign paroxysmal positional vertigo. ( 30149484 )
2018
37
Benign paroxysmal positional vertigo associated with Meniere's disease. ( 30149485 )
2018
38
Assessment of a Statistical Algorithm for the Prediction of Benign Paroxysmal Positional Vertigo. ( 30178063 )
2018
39
Analyses with the Video Head Impulse Test During the Canalith Repositioning Maneuver in Patients with Isolated Posterior Semicircular Canal Benign Paroxysmal Positional Vertigo. ( 30197804 )
2018
40
Anterior Canal benign paroxysmal positional Vertigo following surgical Management of superior canal dehiscence. ( 30224218 )
2018
41
Tumarkin-like phenomenon as a sign of therapeutic success in benign paroxysmal positional vertigo. ( 30231127 )
2018
42
Assessment of Bone Metabolism in Male Patients With Benign Paroxysmal Positional Vertigo. ( 30233488 )
2018
43
Causes of Persistent Positional Vertigo Following Posterior Semicircular Canal Occlusion for Benign Paroxysmal Positional Vertigo. ( 30239433 )
2018
44
Evaluation of Benign Paroxysmal Positional Vertigo in American Football Players. ( 30256203 )
2018
45
Oxidative Status in Patients with Benign Paroxysmal Positional Vertigo. ( 30256204 )
2018
46
Vestibular dysfunction, beyond benign paroxysmal positional vertigo, affects mental rotations: Comment on "Visual dependence and spatial orientation in benign paroxysmal positional vertigo". ( 30282384 )
2018
47
Association of benign paroxysmal positional vertigo with vitamin D deficiency: a systematic review and meta-analysis. ( 30302575 )
2018
48
Diagnosis and treatment of anterior canal benign paroxysmal positional vertigo. ( 30318958 )
2018
49
Recovery of positional nystagmus after benign paroxysmal positional vertigo fatigue. ( 30324405 )
2018
50
Physical Therapy for Posterior and Horizontal Canal Benign Paroxysmal Positional Vertigo: Long-term Effect and Recurrence: A Systematic Review. ( 30357032 )
2018

Variations for Vertigo, Benign Recurrent

Expression for Vertigo, Benign Recurrent

Search GEO for disease gene expression data for Vertigo, Benign Recurrent.

Pathways for Vertigo, Benign Recurrent

GO Terms for Vertigo, Benign Recurrent

Sources for Vertigo, Benign Recurrent

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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