BRV
MCID: VRT013
MIFTS: 39

Vertigo, Benign Recurrent (BRV)

Categories: Genetic diseases

Aliases & Classifications for Vertigo, Benign Recurrent

MalaCards integrated aliases for Vertigo, Benign Recurrent:

Name: Vertigo, Benign Recurrent 58
Vertigo, Benign Paroxysmal Positional 58 13
Benign Paroxysmal Positional Vertigo 74 64
Vertigo, Benign Paroxysmal Positional; Bppv 58
Vestibulopathy, Familial 58
Bppv 58
Brv 58

Characteristics:

OMIM:

58
Inheritance:
autosomal dominant

Miscellaneous:
slowly progressive disorder
acetazolamide may benefit attacks of vertigo


HPO:

33
vertigo, benign recurrent:
Onset and clinical course slow progression
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 58 193007
MedGen 43 C0155502
UMLS 74 C0155502

Summaries for Vertigo, Benign Recurrent

PubMed Health : 64 About benign paroxysmal positional vertigo: Vertigo can be described as a kind of dizziness that makes it feel like everything is spinning around or moving. It can occur while standing, walking or lying down. Depending on what’s causing the dizziness, the length of an episode can vary greatly, and may be accompanied by drowsiness, nausea or other symptoms.The most common cause of this type of vertigo is benign paroxysmal positional vertigo (BPPV). Here certain movements cause dizziness for a short time. BPPV is quite easy to diagnose and treat.

MalaCards based summary : Vertigo, Benign Recurrent, also known as vertigo, benign paroxysmal positional, is related to vertigo, benign recurrent, 2 and benign paroxysmal positional nystagmus, and has symptoms including vertigo, vertigo/dizziness and cupulolithiasis. An important gene associated with Vertigo, Benign Recurrent is BRV2 (Vertigo, Benign Recurrent, 2). The drugs Calcium Carbonate and Ergocalciferol have been mentioned in the context of this disorder. Affiliated tissues include testes, bone and brain, and related phenotypes are gait imbalance and vertigo

OMIM : 58 Benign recurrent vertigo (BRV), also known as benign paroxysmal positional vertigo (BPPV), is a common disorder affecting up to 2% of the adult population. The majority of individuals with chronic recurrent vertigo have no identifiable cause, no progression of the disorder, and no other neurologic or auditory signs. Many families have multiple affected individuals, suggesting familial transmission of the disorder with moderate to high penetrance (summary by Lee et al., 2006). (193007)

Related Diseases for Vertigo, Benign Recurrent

Diseases in the Vertigo, Benign Recurrent family:

Vertigo, Benign Recurrent, 2

Diseases related to Vertigo, Benign Recurrent via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Related Disease Score Top Affiliating Genes
1 vertigo, benign recurrent, 2 12.5
2 benign paroxysmal positional nystagmus 12.2
3 osteoporosis 10.6
4 bone mineral density quantitative trait locus 8 10.5
5 bone mineral density quantitative trait locus 15 10.5
6 sensorineural hearing loss 10.5
7 sudden sensorineural hearing loss 10.5
8 anxiety 10.5
9 thyroiditis 10.3
10 inner ear disease 10.2
11 meniere disease 10.1
12 migraine with or without aura 1 10.1
13 spondyloarthropathy 1 10.1
14 epidermoid cysts 10.1
15 scleroderma, familial progressive 10.1
16 spinocerebellar ataxia 6 10.1
17 aging 10.1
18 orthostatic intolerance 10.1
19 nasopharyngeal carcinoma 10.1
20 meningioma, familial 10.1
21 hydrocephalus 10.1
22 spinal cord injury 10.1
23 cholesteatoma of middle ear 10.1
24 spinal meningioma 10.1
25 otosclerosis 10.1
26 acoustic neuroma 10.1
27 dementia 10.1
28 autosomal dominant cerebellar ataxia 10.1
29 personality disorder 10.1
30 hyperinsulinism 10.1
31 auditory system disease 10.1
32 neurilemmoma 10.1
33 ischemia 10.1
34 hyperglycemia 10.1
35 secretory meningioma 10.1
36 intracranial hypotension 10.1
37 benign ependymoma 10.1
38 spondylitis 10.1
39 pathologic nystagmus 10.1
40 broken heart syndrome 10.1
41 congenital hydrocephalus 10.1
42 ependymoma 10.1
43 perilymphatic fistula 10.1
44 pure autonomic failure 10.1
45 depression 10.1
46 syncope 10.1
47 spontaneous intracranial hypotension 10.1
48 cytomegalic congenital adrenal hypoplasia 10.1
49 deafness, autosomal recessive 4, with enlarged vestibular aqueduct 10.0
50 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.0

Comorbidity relations with Vertigo, Benign Recurrent via Phenotypic Disease Network (PDN): (show all 11)


Anxiety Basilar Artery Insufficiency
Chronic Myocardial Ischemia Esophagitis
Hypertension, Essential Hypothyroidism
Intermediate Coronary Syndrome Ischemic Heart Disease
Labyrinthitis Transient Cerebral Ischemia
Vertebral Artery Insufficiency

Graphical network of the top 20 diseases related to Vertigo, Benign Recurrent:



Diseases related to Vertigo, Benign Recurrent

Symptoms & Phenotypes for Vertigo, Benign Recurrent

Human phenotypes related to Vertigo, Benign Recurrent:

33
# Description HPO Frequency HPO Source Accession
1 gait imbalance 33 HP:0002141
2 vertigo 33 HP:0002321

Symptoms via clinical synopsis from OMIM:

58
Neurologic Central Nervous System:
gait imbalance
vertigo, episodic (onset in second or third decade)
vestibulopathy, bilateral, progressive (onset in fourth or fifth decade)
oscillopsia

Head And Neck Ears:
vertigo, episodic
vestibulopathy, bilateral, progressive
no hearing loss

Clinical features from OMIM:

193007

UMLS symptoms related to Vertigo, Benign Recurrent:


vertigo, vertigo/dizziness, cupulolithiasis

Drugs & Therapeutics for Vertigo, Benign Recurrent

PubMedHealth treatment related to Vertigo, Benign Recurrent: 64

“Repositioning” procedures or maneuvers are commonly used to treat BPPV. They involve moving the patient into specific lying or sitting positions following a certain sequence, with specific positions of the head. The sequence of movements is designed to help move the tiny crystals out of the posterior semicircular canal and into areas of the vestibular system where they can no longer disturb the sensory hair cells.The Epley maneuver and the Semont maneuver are two very simple and effective repositioning procedures for the treatment of BPPV caused by crystals in the posterior semicircular canal. These maneuvers are typically done several times with the help of a doctor. There are also slightly modified repositioning procedures that can be done at home in addition to the doctor-assisted maneuvers.The crystals are only rarely found in either of the other semicircular canals. Then other repositioning maneuvers can be used.Medication can help if the vertigo is causing nausea.If the symptoms persist, surgery on the vestibular system may be considered. This involves destroying either the nerve fibers that are connected to the affected semicircular canal, or the semicircular canal itself. The hair cells can then no longer transmit misleading information – or any other information – to the brain. This means that the vestibular system in that ear is permanently affected by the surgery.

Drugs for Vertigo, Benign Recurrent (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 52)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Calcium Carbonate Approved, Investigational Phase 4 471-34-1
2
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
3
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
4
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 5280795 6221
5
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
6 Calciferol Phase 4
7 Bone Density Conservation Agents Phase 4
8 Ergocalciferols Phase 4
9 Vitamin D2 Phase 4
10 Anti-Ulcer Agents Phase 4
11 Hormones Phase 4
12 Nutrients Phase 4
13 Trace Elements Phase 4
14 Vitamins Phase 4
15 Micronutrients Phase 4
16 Calcium Supplement Phase 4
17 Calcium, Dietary Phase 4
18 Antacids Phase 4
19 Gastrointestinal Agents Phase 4,Not Applicable
20
Histamine Approved, Investigational Not Applicable 51-45-6 774
21
Meclizine Approved Not Applicable 569-65-3 4034
22
Promethazine Approved, Investigational Not Applicable 60-87-7 4927
23
Ondansetron Approved Not Applicable 99614-02-5 4595
24
Diazepam Approved, Illicit, Investigational, Vet_approved Not Applicable 439-14-5 3016
25
Diphenhydramine Approved, Investigational Not Applicable 147-24-0, 58-73-1 3100
26
Lorazepam Approved Not Applicable 846-49-1 3958
27
Betahistine Approved, Investigational Not Applicable 5638-76-6 2366
28 Hypnotics and Sedatives Not Applicable
29 Tranquilizing Agents Not Applicable
30 Histamine Antagonists Not Applicable
31 Anticonvulsants Not Applicable
32 GABA Agents Not Applicable
33 Dermatologic Agents Not Applicable
34 Antipruritics Not Applicable
35 Antiemetics Not Applicable
36 GABA Modulators Not Applicable
37 Antipsychotic Agents Not Applicable
38 Anti-Anxiety Agents Not Applicable
39 Anesthetics Not Applicable
40 Anesthetics, Local Not Applicable
41 Histamine H1 Antagonists Not Applicable
42 Serotonin Agents Not Applicable
43 Serotonin Antagonists Not Applicable
44 Neurotransmitter Agents Not Applicable
45 Autonomic Agents Not Applicable
46 Psychotropic Drugs Not Applicable
47 Anti-Allergic Agents Not Applicable
48 Central Nervous System Depressants Not Applicable
49 Peripheral Nervous System Agents Not Applicable
50
Histamine Phosphate Not Applicable 51-74-1 65513

Interventional clinical trials:

(show all 36)
# Name Status NCT ID Phase Drugs
1 Efficacy of Vitamin D and Calcium Supplementation on the Prevention of Recurrences in BPPV Completed NCT02031692 Phase 4 400IU cholecalciferol and 500mg of elemental calcium as calcium carbonate
2 The Treatment of Posterior Semicircular Canal Benign Paroxysmal Positional Vertigo Completed NCT02029508 Phase 3
3 Treatment of Geotropic Horizontal Canal Benign Paroxysmal Positional Vertigo Completed NCT01366430 Phase 3
4 Treatment of Apogeotropic Horizontal Canal Benign Paroxysmal Positional Vertigo Completed NCT00810641 Phase 3
5 Canalith Repositioning Procedure for BPPV in Primary Care Completed NCT00182273 Phase 3
6 Visual Feedback Goggle for Positional Vertigo Treatment Unknown status NCT00729885 Phase 1, Phase 2
7 Treatment of Apogeotropic Horizontal Canal Benign Paroxysmal Positional Vertigo Completed NCT02046980 Phase 2
8 Treatments for Benign Paroxysmal Positional Vertigo (BPPV) Completed NCT00000359 Phase 2
9 Efficacy of Postural Restriction in Treating Benign Paroxysmal Positional Vertigo Unknown status NCT02475239 Not Applicable
10 Treatment of Posterior Canal Type of Benign Paroxysmal Positional Vertigo Unknown status NCT01822002 Not Applicable
11 The Liberatory Maneuver for the Treatment of Benign Paroxysmal Positional Vertigo (BPPV) Unknown status NCT01008124 Not Applicable
12 Comparison of Home-Based Exercise on the Posterior Canal Benign Paroxysmal Positional Vertigo Symptoms Completed NCT03230513 Not Applicable
13 Cranial Osteopathic Techniques on the Symptoms of Benign Paroxysmal Positional Vertigo Completed NCT03854084 Not Applicable
14 Evidence Based Best Care Practice for Benign Paroxysmal Positional Vertigo Completed NCT02809599 Not Applicable
15 Treating Benign Paroxysmal Positional Vertigo (BPPV) in ED Patients Completed NCT00641797 Not Applicable Meclizine;Lorazepam;Diphenhydramine;Ondansetron
16 Vestibular Evoked Myogenic Potentials in Benign Paroxysmal Positional Vertigo (VEMP in BPPV) Completed NCT01004913
17 BPPV Treatment in Biaxial Rotational Chair Completed NCT01905800 Not Applicable
18 Clinical Aspects of Patients With Benign Paroxysmal Positional Vertigo (BPPV) and Migraine Completed NCT02615314
19 Effectiveness of the Epley Manoeuvre Performed in Primary Care to Treat Benign Paroxysmal Positional Vertigo Completed NCT01969513 Not Applicable
20 Effectiveness of Osteopathic Manipulative Treatment (OMT) and Vestibular Rehabilitation Therapy (VRT) in Individuals With Vertigo Completed NCT01529151 Not Applicable
21 To Study the Characteristics of Different Types of Vertigo in Patients Attending the Ear Nose & Throat (ENT) Clinics. Completed NCT02213120
22 Osteotome Sinus Floor Elevation With or Without Grafting Completed NCT01619956 Not Applicable
23 Sinus Lift: Saving Time and Reducing Morbidity Completed NCT02415946 Not Applicable
24 Different Treatments With the TRV Reposition Chair Recruiting NCT03541018 Not Applicable
25 BPPV With CRP: Single Versus Multiple Cycles Recruiting NCT02701218 Not Applicable
26 Inactivity, Balance Problems and Fall Risk in Institutionalized Frail Elderly Recruiting NCT02905292
27 Interventions for Residual Dizziness After Successful Repositioning Maneuvers in Patients With BPPV Recruiting NCT03624283 Not Applicable Betahistine
28 3D Model of Posterior Membranous Labyrinth of the Inner Ear Recruiting NCT03295929
29 Acute Video-oculography for Vertigo in Emergency Rooms for Rapid Triage (AVERT) Recruiting NCT02483429 Not Applicable
30 Clinical Evaluation of Two Types of Transalveolar Sinus Floor Elevation Recruiting NCT03445039 Not Applicable
31 Efficacy of a Mechanical Chair for Treatment of Benign Paroxysmal Positional Vertigo (BPPV) Enrolling by invitation NCT03161470 Not Applicable
32 Benign Paroxysmal Positional Vertigo (BPPV) Training for Sports Medicine Providers in a Pediatric Concussion Program Not yet recruiting NCT03425786 Not Applicable
33 TRV-chair vs Manual Repositioning Maneuver in Treatment of Benign Paroxysmal Positional Vertigo Not yet recruiting NCT03871413 Not Applicable
34 Evaluation of the Prevalence of BPPV and Longterm Effects of Its Therapy Using the Rotundum Device in Retirement Homes Not yet recruiting NCT03643354 Not Applicable
35 The Influence of Vestibular Stimulation on Cardiac Autonomic Control System in Subjects With and Without BPPV Not yet recruiting NCT03867019
36 Effects of Physical Treatment on Postural Stability in Benign Paroxysmal Positional Vertigo (BPPV) Patients Withdrawn NCT00978809 Not Applicable

Search NIH Clinical Center for Vertigo, Benign Recurrent

Genetic Tests for Vertigo, Benign Recurrent

Anatomical Context for Vertigo, Benign Recurrent

MalaCards organs/tissues related to Vertigo, Benign Recurrent:

42
Testes, Bone, Brain, Thyroid, Spinal Cord, Cerebellum

Publications for Vertigo, Benign Recurrent

Articles related to Vertigo, Benign Recurrent:

(show top 50) (show all 849)
# Title Authors Year
1
Effects of treatment on anxiety levels among patients with benign paroxysmal positional vertigo. ( 30666439 )
2019
2
Otolith dysfunction in recurrent benign paroxysmal positional vertigo after mild traumatic brain injury. ( 30714506 )
2019
3
Increased risk of benign paroxysmal positional vertigo in osteoporosis: a nationwide population-based cohort study. ( 30837524 )
2019
4
Benign paroxysmal positional vertigo and osteoporosis. ( 30554357 )
2019
5
Association Between Migraine and Benign Paroxysmal Positional Vertigo Among Adults in South Korea. ( 30676633 )
2019
6
Effect of Epley, Semont Maneuvers and Brandt-Daroff Exercise on Quality of Life in Patients with Posterior Semicircular Canal Benign Paroxysmal Positional Vertigo (PSCBPPV). ( 30906723 )
2019
7
Benign paroxysmal positional vertigo in children. ( 30220115 )
2019
8
Increased Risk of Benign Paroxysmal Positional Vertigo in Patients With a History of Sudden Sensory Neural Hearing Loss: A Longitudinal Follow-up Study Using a National Sample Cohort. ( 30624405 )
2019
9
Clinical features of benign paroxysmal positional vertigo of the posterior semicircular canal. ( 30637105 )
2019
10
Analysis of cost and effectiveness of treatment in benign paroxysmal positional vertigo. ( 30681502 )
2019
11
Poor Treatment Outcomes Following Repositioning Maneuvers in Younger and Older Adults With Benign Paroxysmal Positional Vertigo: A Systematic Review and Meta-analysis. ( 30691621 )
2019
12
Diagnosis and treatment choices of suspected benign paroxysmal positional vertigo: current approach of general practitioners, neurologists, and ENT physicians. ( 30694376 )
2019
13
Correlations of Calcium Voltage-Gated Channel Subunit Alpha1 A (CACNA1A) Gene Polymorphisms with Benign Paroxysmal Positional Vertigo. ( 30710491 )
2019
14
Sitting Up Vertigo. Proposed Variant of Posterior Canal Benign Paroxysmal Positional Vertigo. ( 30807523 )
2019
15
Serum Vitamin D and Long-Term Outcomes of Benign Paroxysmal Positional Vertigo. ( 30813712 )
2019
16
Use of the Bárány Society criteria to diagnose benign paroxysmal positional vertigo. ( 30814370 )
2019
17
Association Between Serum Uric Acid Levels and Benign Paroxysmal Positional Vertigo: A Systematic Review and Meta-Analysis of Observational Studies. ( 30828314 )
2019
18
Benign paroxysmal positional vertigo. ( 30828628 )
2019
19
Sitting Up Vertigo. Proposed Variant of Posterior Canal Benign Paroxysmal Positional Vertigo. ( 30870365 )
2019
20
Difference in Serum Levels of Vitamin D Between Canalolithiasis and Cupulolithiasis of the Horizontal Semicircular Canal in Benign Paroxysmal Positional Vertigo. ( 30881337 )
2019
21
Impaired Calcium Metabolism in Benign Paroxysmal Positional Vertigo: A Topical Review. ( 30883492 )
2019
22
Reduction of bone mineral density in native Chinese female idiopathic benign paroxysmal positional vertigo patients. ( 29042068 )
2018
23
Aging Is a Risk Factor for Utricular Dysfunction in Idiopathic Benign Paroxysmal Positional Vertigo. ( 30559714 )
2018
24
Anxiety, Mood, and Personality Disorders in Patients with Benign Paroxysmal Positional Vertigo. ( 30042641 )
2018
25
Benign paroxysmal positional vertigo in patients after mild traumatic brain injury. ( 30058780 )
2018
26
Fourth ventricle ependymoma mimicking benign paroxysmal positional vertigo. ( 30104227 )
2018
27
Benign paroxysmal positional vertigo in spontaneous intracranial hypotension. ( 30052143 )
2018
28
Subjective benign paroxysmal positional vertigo in patients with osteoporosis or migraine. ( 30482521 )
2018
29
Osteoporosis increases the risk of benign paroxysmal positional vertigo: a nested case-control study using a national sample cohort. ( 30511104 )
2018
30
The prevalence of benign paroxysmal positional vertigo in patients with osteoporosis. ( 30315360 )
2018
31
Idiopathic benign paroxysmal positional vertigo with persistent vertigo/dizziness sensation is associated with latent canal paresis, endolymphatic hydrops, and osteoporosis. ( 30042018 )
2018
32
In reference to Otoconia and Otolithic Membrane Fragments Within the Posterior Semicircular Canal in Benign Paroxysmal Positional Vertigo. ( 28782301 )
2018
33
Practice Guidelines for the Diagnosis and Management of Benign Paroxysmal Positional Vertigo Otoneurology Committee of Spanish Otorhinolaryngology and Head and Neck Surgery Consensus Document. ( 28826856 )
2018
34
Our experience with 500 patients with benign paroxysmal positional vertigo: Reexploring aetiology and reevaluating MRI investigation. ( 28943053 )
2018
35
Development and face validation of a Virtual Reality Epley Maneuver System (VREMS) for home Epley treatment of benign paroxysmal positional vertigo: A randomized, controlled trial. ( 29169952 )
2018
36
Potential Risk Factors Affecting Repeated Canalith Repositioning Procedures in Benign Paroxysmal Positional Vertigo. ( 29227441 )
2018
37
Low 25-hydroxyvitamin D levels in postmenopausal female patients with benign paroxysmal positional vertigo. ( 29272984 )
2018
38
Benign Paroxysmal Positional Vertigo (BPPV) in Children and Adolescents: Clinical Features and Response to Therapy in 110 Pediatric Patients. ( 29287036 )
2018
39
OMT May Be Helpful in the Management of Benign Paroxysmal Positional Vertigo. ( 29309095 )
2018
40
The use of mastoid vibration with canalith repositioning procedure to treat persistent benign paroxysmal positional vertigo: A case report. ( 29336656 )
2018
41
Visual dependence and spatial orientation in benign paroxysmal positional vertigo. ( 29400684 )
2018
42
Bone mineral density and serum 25-hydroxyvitamin D in patients with idiopathic benign paroxysmal positional vertigo. ( 29400685 )
2018
43
Teaching Patient-Centered Counseling Skills for Assessment, Diagnosis, and Management of Benign Paroxysmal Positional Vertigo. ( 29422713 )
2018
44
Successful management of benign paroxysmal positional vertigo (BPPV) in a patient who was ventilated with a C3 complete spinal injury on a regional spinal unit intensive care. ( 29437815 )
2018
45
Analysis of effect of 1α-hydroxyvitamin D3 on benign paroxysmal positional vertigo and risk factors. ( 29456639 )
2018
46
Utility of the bow and lean test in predicting subtype of benign paroxysmal positional vertigo. ( 29481705 )
2018
47
Analysis of non-posterior canal benign paroxysmal positional vertigo in patients treated using the particle repositioning chair: A large, single-institution series. ( 29544670 )
2018
48
The aVOR App Increases Medical Students' Competence in Treating Benign Paroxysmal Positional Vertigo (BPPV). ( 29579015 )
2018
49
Presence of Anxiety and Depression Symptoms Affects the First Time Treatment Efficacy and Recurrence of Benign Paroxysmal Positional Vertigo. ( 29619005 )
2018
50
Recurrence in Benign Paroxysmal Positional Vertigo: A Large, Single-Institution Study. ( 29649052 )
2018

Variations for Vertigo, Benign Recurrent

Expression for Vertigo, Benign Recurrent

Search GEO for disease gene expression data for Vertigo, Benign Recurrent.

Pathways for Vertigo, Benign Recurrent

GO Terms for Vertigo, Benign Recurrent

Sources for Vertigo, Benign Recurrent

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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