MCID: VRT013
MIFTS: 33

Vertigo, Benign Recurrent

Categories: Genetic diseases

Aliases & Classifications for Vertigo, Benign Recurrent

MalaCards integrated aliases for Vertigo, Benign Recurrent:

Name: Vertigo, Benign Recurrent 57
Vertigo, Benign Paroxysmal Positional 57 13
Vertigo, Benign Paroxysmal Positional; Bppv 57
Benign Paroxysmal Positional Vertigo 73
Vestibulopathy, Familial 57
Bppv 57
Brv 57

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant

Miscellaneous:
slowly progressive disorder
acetazolamide may benefit attacks of vertigo


HPO:

32
vertigo, benign recurrent:
Inheritance autosomal dominant inheritance
Onset and clinical course slow progression


Classifications:



External Ids:

OMIM 57 193007
MedGen 42 C0155502

Summaries for Vertigo, Benign Recurrent

OMIM : 57 Benign recurrent vertigo (BRV), also known as benign paroxysmal positional vertigo (BPPV), is a common disorder affecting up to 2% of the adult population. The majority of individuals with chronic recurrent vertigo have no identifiable cause, no progression of the disorder, and no other neurologic or auditory signs. Many families have multiple affected individuals, suggesting familial transmission of the disorder with moderate to high penetrance (summary by Lee et al., 2006). (193007)

MalaCards based summary : Vertigo, Benign Recurrent, also known as vertigo, benign paroxysmal positional, is related to vertigo, benign recurrent, 2 and benign paroxysmal positional nystagmus, and has symptoms including vertigo, cupulolithiasis and vertigo/dizziness. An important gene associated with Vertigo, Benign Recurrent is BRV2 (Vertigo, Benign Recurrent, 2). The drugs Calcium Carbonate and Ergocalciferol have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and thyroid, and related phenotypes are gait imbalance and vertigo

Related Diseases for Vertigo, Benign Recurrent

Diseases in the Vertigo, Benign Recurrent family:

Vertigo, Benign Recurrent, 2

Diseases related to Vertigo, Benign Recurrent via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 vertigo, benign recurrent, 2 12.3
2 benign paroxysmal positional nystagmus 12.0

Comorbidity relations with Vertigo, Benign Recurrent via Phenotypic Disease Network (PDN): (show all 11)


Anxiety Basilar Artery Insufficiency
Chronic Myocardial Ischemia Esophagitis
Hypertension, Essential Hypothyroidism
Intermediate Coronary Syndrome Ischemic Heart Disease
Labyrinthitis Transient Cerebral Ischemia
Vertebral Artery Insufficiency

Symptoms & Phenotypes for Vertigo, Benign Recurrent

Symptoms via clinical synopsis from OMIM:

57
Head And Neck Ears:
vertigo, episodic
vestibulopathy, bilateral, progressive
no hearing loss

Neurologic Central Nervous System:
vertigo, episodic (onset in second or third decade)
vestibulopathy, bilateral, progressive (onset in fourth or fifth decade)
gait imbalance
oscillopsia


Clinical features from OMIM:

193007

Human phenotypes related to Vertigo, Benign Recurrent:

32
# Description HPO Frequency HPO Source Accession
1 gait imbalance 32 HP:0002141
2 vertigo 32 HP:0002321

UMLS symptoms related to Vertigo, Benign Recurrent:


vertigo, cupulolithiasis, vertigo/dizziness

Drugs & Therapeutics for Vertigo, Benign Recurrent

Drugs for Vertigo, Benign Recurrent (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 49)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Calcium Carbonate Approved, Investigational Phase 4 471-34-1
2
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
3
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
4
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 6221 5280795
5 Antacids Phase 4
6 Anti-Ulcer Agents Phase 4
7 Bone Density Conservation Agents Phase 4
8 Calcium, Dietary Phase 4
9 Ergocalciferols Phase 4
10 Gastrointestinal Agents Phase 4,Not Applicable
11 Micronutrients Phase 4
12 Trace Elements Phase 4
13 Vitamins Phase 4
14 Calciferol Nutraceutical Phase 4
15 Calcium Supplement Nutraceutical Phase 4
16 Vitamin D2 Nutraceutical Phase 4
17
Menthol Approved Not Applicable 2216-51-5 16666
18
Diazepam Approved, Illicit, Investigational, Vet_approved Not Applicable 439-14-5 3016
19
Diphenhydramine Approved, Investigational Not Applicable 147-24-0, 58-73-1 3100
20
Histamine Approved, Investigational Not Applicable 75614-87-8, 51-45-6 774
21
Lorazepam Approved Not Applicable 846-49-1 3958
22
Meclizine Approved Not Applicable 569-65-3 4034
23
Ondansetron Approved Not Applicable 99614-02-5 4595
24
Promethazine Approved, Investigational Not Applicable 60-87-7 4927
25
Betahistine Approved, Investigational Not Applicable 5638-76-6 2366
26 Anesthetics Not Applicable
27 Anesthetics, Local Not Applicable
28 Anti-Allergic Agents Not Applicable
29 Anti-Anxiety Agents Not Applicable
30 Anticonvulsants Not Applicable
31 Antiemetics Not Applicable
32 Antipruritics Not Applicable
33 Antipsychotic Agents Not Applicable
34 Autonomic Agents Not Applicable
35 Central Nervous System Depressants Not Applicable
36 Dermatologic Agents Not Applicable
37 GABA Agents Not Applicable
38 GABA Modulators Not Applicable
39 Histamine Antagonists Not Applicable
40 Histamine H1 Antagonists Not Applicable
41
Histamine Phosphate Not Applicable 51-74-1 65513
42 Hypnotics and Sedatives Not Applicable
43 Neurotransmitter Agents Not Applicable
44 Peripheral Nervous System Agents Not Applicable
45 Psychotropic Drugs Not Applicable
46 Serotonin Agents Not Applicable
47 Serotonin Antagonists Not Applicable
48 Tranquilizing Agents Not Applicable
49
Serotonin Investigational, Nutraceutical Not Applicable 50-67-9 5202

Interventional clinical trials:

(show all 31)
# Name Status NCT ID Phase Drugs
1 Efficacy of Vitamin D and Calcium Supplementation on the Prevention of Recurrences in BPPV Completed NCT02031692 Phase 4 400IU cholecalciferol and 500mg of elemental calcium as calcium carbonate
2 The Treatment of Posterior Semicircular Canal Benign Paroxysmal Positional Vertigo Completed NCT02029508 Phase 3
3 Treatment of Geotropic Horizontal Canal Benign Paroxysmal Positional Vertigo Completed NCT01366430 Phase 3
4 Treatment of Apogeotropic Horizontal Canal Benign Paroxysmal Positional Vertigo Completed NCT00810641 Phase 3
5 Canalith Repositioning Procedure for BPPV in Primary Care Completed NCT00182273 Phase 3
6 Visual Feedback Goggle for Positional Vertigo Treatment Unknown status NCT00729885 Phase 1, Phase 2
7 Treatment of Apogeotropic Horizontal Canal Benign Paroxysmal Positional Vertigo Completed NCT02046980 Phase 2
8 Treatments for Benign Paroxysmal Positional Vertigo (BPPV) Completed NCT00000359 Phase 2
9 Efficacy of Postural Restriction in Treating Benign Paroxysmal Positional Vertigo Unknown status NCT02475239 Not Applicable
10 Treatment of Posterior Canal Type of Benign Paroxysmal Positional Vertigo Unknown status NCT01822002 Not Applicable
11 The Liberatory Maneuver for the Treatment of Benign Paroxysmal Positional Vertigo (BPPV) Unknown status NCT01008124 Not Applicable
12 Comparison of Home-Based Exercise on the Posterior Canal Benign Paroxysmal Positional Vertigo Symptoms Completed NCT03230513 Not Applicable
13 Treating Benign Paroxysmal Positional Vertigo (BPPV) in ED Patients Completed NCT00641797 Not Applicable Meclizine;Lorazepam;Diphenhydramine;Ondansetron
14 Vestibular Evoked Myogenic Potentials in Benign Paroxysmal Positional Vertigo (VEMP in BPPV) Completed NCT01004913
15 BPPV Treatment in Biaxial Rotational Chair Completed NCT01905800 Not Applicable
16 Clinical Aspects of Patients With Benign Paroxysmal Positional Vertigo (BPPV) and Migraine Completed NCT02615314
17 Effectiveness of the Epley Manoeuvre Performed in Primary Care to Treat Benign Paroxysmal Positional Vertigo Completed NCT01969513 Not Applicable
18 Effectiveness of Osteopathic Manipulative Treatment (OMT) and Vestibular Rehabilitation Therapy (VRT) in Individuals With Vertigo Completed NCT01529151 Not Applicable
19 To Study the Characteristics of Different Types of Vertigo in Patients Attending the Ear Nose & Throat (ENT) Clinics. Completed NCT02213120
20 Osteotome Sinus Floor Elevation With or Without Grafting Completed NCT01619956 Not Applicable
21 Sinus Lift: Saving Time and Reducing Morbidity Completed NCT02415946 Not Applicable
22 Different Treatments With the TRV Reposition Chair Recruiting NCT03541018 Not Applicable
23 BPPV With CRP: Single Versus Multiple Cycles Recruiting NCT02701218 Not Applicable
24 Inactivity, Balance Problems and Fall Risk in Institutionalized Frail Elderly Recruiting NCT02905292
25 3D Model of Posterior Membranous Labyrinth of the Inner Ear Recruiting NCT03295929
26 Acute Video-oculography for Vertigo in Emergency Rooms for Rapid Triage (AVERT) Recruiting NCT02483429 Not Applicable
27 Clinical Evaluation of Two Types of Transalveolar Sinus Floor Elevation Recruiting NCT03445039 Not Applicable
28 Evidence Based Best Care Practice for Benign Paroxysmal Positional Vertigo Enrolling by invitation NCT02809599 Not Applicable
29 Efficacy of a Mechanical Chair for Treatment of Benign Paroxysmal Positional Vertigo (BPPV) Enrolling by invitation NCT03161470 Not Applicable
30 Benign Paroxysmal Positional Vertigo (BPPV) Training for Sports Medicine Providers in a Pediatric Concussion Program Not yet recruiting NCT03425786 Not Applicable
31 Effects of Physical Treatment on Postural Stability in Benign Paroxysmal Positional Vertigo (BPPV) Patients Withdrawn NCT00978809 Not Applicable

Search NIH Clinical Center for Vertigo, Benign Recurrent

Genetic Tests for Vertigo, Benign Recurrent

Anatomical Context for Vertigo, Benign Recurrent

MalaCards organs/tissues related to Vertigo, Benign Recurrent:

41
Bone, Testes, Thyroid

Publications for Vertigo, Benign Recurrent

Articles related to Vertigo, Benign Recurrent:

(show top 50) (show all 109)
# Title Authors Year
1
Reduction of bone mineral density in native Chinese female idiopathic benign paroxysmal positional vertigo patients. ( 29042068 )
2018
2
Factors Associated with Benign Paroxysmal Positional Vertigo: A Chinese Case-Control Study. ( 28800356 )
2017
3
Unilateral posterior canal-plugging surgery for intractable bilateral posterior canal-type benign paroxysmal positional vertigo. ( 27979611 )
2017
4
Residual Dizziness after Successful Repositioning Maneuver for Idiopathic Benign Paroxysmal Positional Vertigo: A Review. ( 28603599 )
2017
5
[Diagnosis and treatment of benign paroxysmal positional vertigo in common clinical practice]. ( 28252629 )
2017
6
Benign paroxysmal positional vertigo: Diagnostic criteria Consensus document of the Committee for the Classification of Vestibular Disorders of the BA!rA!ny Society. ( 29056234 )
2017
7
Efficacy of cervical and ocular vestibular-evoked myogenic potentials in evaluation of benign paroxysmal positional vertigo of posterior semicircular canal. ( 26718546 )
2016
8
[The false-negative reasons of positioning test in benign paroxysmal positional vertigo]. ( 27197448 )
2016
9
Benign Paroxysmal Positional Vertigo: Our Experience. ( 27066408 )
2016
10
[Relationship between serum level of uric acid and benign paroxysmal positional vertigo]. ( 26168668 )
2015
11
Diagnostic Role of Head-Bending and Lying-Down Tests in Lateral Canal Benign Paroxysmal Positional Vertigo. ( 25938792 )
2015
12
First-referral presentations of patients with benign paroxysmal positional vertigo who were negative on positional testing and who lacked nystagmus. ( 25416308 )
2015
13
[Treatment of anterior canal benign paroxysmal positional vertigo by Yacovino repositioning maneuver]. ( 25966547 )
2015
14
Investigating the role of Sirt1-modulated oxidative stress in relation to benign paroxysmal positional vertigo and Parkinson's disease. ( 26130063 )
2015
15
Benign Paroxysmal Positional Vertigo in the Acute Care Setting. ( 26231274 )
2015
16
Canal switch and re-entry phenomenon in benign paroxysmal positional vertigo: difference between immediate and delayed occurrence. ( 26019396 )
2015
17
Efficacy of computer-controlled repositioning procedure for benign paroxysmal positional vertigo. ( 25302789 )
2015
18
Canalith repositioning in apogeotropic horizontal canal benign paroxysmal positional vertigo: Do we need faster maneuvering? ( 26341154 )
2015
19
Surgical management for benign paroxysmal positional vertigo of the superior semicircular canal. ( 25583673 )
2015
20
Management of 210 patients with benign paroxysmal positional vertigo: AMC protocol and outcomes. ( 25678222 )
2015
21
Utricular Dysfunction in Refractory Benign Paroxysmal Positional Vertigo. ( 24769628 )
2014
22
Do platelet indices have a role in benign paroxysmal positional vertigo? ( 24620977 )
2014
23
One-third of vertiginous episodes during the follow-up period are caused by benign paroxysmal positional vertigo in patients with Meniere's disease. ( 25166020 )
2014
24
Experimental study on the aetiology of benign paroxysmal positional vertigo due to canalolithiasis: comparison between normal and vestibular dysfunction models. ( 24423787 )
2014
25
Management of benign paroxysmal positional vertigo: a randomized controlled trial. ( 24462034 )
2014
26
Lying-down nystagmus and head-bending nystagmus in horizontal semicircular canal benign paroxysmal positional vertigo: are they useful for lateralization? ( 25413310 )
2014
27
Clinical significance of orthostatic dizziness in the diagnosis of benign paroxysmal positional vertigo and orthostatic intolerance. ( 23790615 )
2013
28
[Clinical characteristics of benign paroxysmal positional vertigo secondary to sudden deafness]. ( 23646430 )
2013
29
Osteoporosis as a risk factor for the recurrence of benign paroxysmal positional vertigo. ( 23568754 )
2013
30
Clinical analysis of patients with idiopathic sudden sensorineural hearing loss and benign paroxysmal positional vertigo. ( 23294198 )
2013
31
Benign paroxysmal positional vertigo. ( 24057823 )
2013
32
Benign paroxysmal positional vertigo secondary to vestibular neuritis. ( 23575935 )
2013
33
Autonomic dysfunction as a possible cause of residual dizziness after successful treatment in benign paroxysmal positional vertigo. ( 24045026 )
2013
34
Impact of postmaneuver sleep position on recurrence of benign paroxysmal positional vertigo. ( 24367602 )
2013
35
Impaired mental rotation in benign paroxysmal positional vertigo and acute vestibular neuritis. ( 24324422 )
2013
36
Residual dizziness after successful repositioning maneuvers for idiopathic benign paroxysmal positional vertigo. ( 23774304 )
2013
37
Benign paroxysmal positional vertigo is not a prognostic factor in sudden sensorineural hearing loss. ( 22157264 )
2012
38
Pseudo-spontaneous nystagmus in lateral semicircular canal benign paroxysmal positional vertigo. ( 23205224 )
2012
39
Idiopathic sudden sensorineural hearing loss and comorbid benign paroxysmal positional vertigo: some pathogenic additional considerations. ( 22525218 )
2012
40
Benign paroxysmal positional vertigo accompanied by sudden sensorineural hearing loss: a comparative study with idiopathic benign paroxysmal positional vertigo. ( 22915291 )
2012
41
Evaluation of quality of life pre- and post-vestibular rehabilitation in patients with benign paroxysmal positional vertigo associated with Meniere's disease. ( 25991970 )
2012
42
Benign paroxysmal positional vertigo associated with Meniere's disease: epidemiological, pathophysiologic, clinical, and therapeutic aspects. ( 23130545 )
2012
43
Comorbid benign paroxysmal positional vertigo in idiopathic sudden sensorineural hearing loss: an ominous sign for hearing recovery. ( 22215458 )
2012
44
A case of isolated cerebellar hemorrhage presenting as vestibular neuritis combined with contralateral benign paroxysmal positional vertigo. ( 21987651 )
2012
45
Enlarged vestibular aqueduct may precipitate benign paroxysmal positional vertigo in children. ( 22582772 )
2012
46
Benign paroxysmal positional vertigo is a common cause of dizziness and unsteadiness in a large population of 75-year-olds. ( 23238307 )
2012
47
Randomized clinical trial for apogeotropic horizontal canal benign paroxysmal positional vertigo. ( 22170885 )
2012
48
Clinical evaluation of posterior canal benign paroxysmal positional vertigo. ( 23271854 )
2012
49
Persistent positional nystagmus: a case of superior semicircular canal benign paroxysmal positional vertigo? ( 21792975 )
2011
50
Inner ear disease and benign paroxysmal positional vertigo: a critical review of incidence, clinical characteristics, and management. ( 21837242 )
2011

Variations for Vertigo, Benign Recurrent

Expression for Vertigo, Benign Recurrent

Search GEO for disease gene expression data for Vertigo, Benign Recurrent.

Pathways for Vertigo, Benign Recurrent

GO Terms for Vertigo, Benign Recurrent

Sources for Vertigo, Benign Recurrent

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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