BRV
MCID: VRT013
MIFTS: 31

Vertigo, Benign Recurrent (BRV)

Categories: Genetic diseases

Aliases & Classifications for Vertigo, Benign Recurrent

MalaCards integrated aliases for Vertigo, Benign Recurrent:

Name: Vertigo, Benign Recurrent 57
Vestibulopathy, Familial 57 13
Vertigo, Benign Paroxysmal Positional; Bppv 57
Vertigo, Benign Paroxysmal Positional 57
Benign Paroxysmal Positional Vertigo 70
Bppv 57
Brv 57

Characteristics:

OMIM®:

57 (Updated 20-May-2021)
Inheritance:
autosomal dominant

Miscellaneous:
slowly progressive disorder
acetazolamide may benefit attacks of vertigo


HPO:

31
vertigo, benign recurrent:
Inheritance autosomal dominant inheritance
Onset and clinical course slow progression


Classifications:



External Ids:

OMIM® 57 193007
MedGen 41 C0155502
UMLS 70 C0155502

Summaries for Vertigo, Benign Recurrent

OMIM® : 57 Benign recurrent vertigo (BRV), also known as benign paroxysmal positional vertigo (BPPV), is a common disorder affecting up to 2% of the adult population. The majority of individuals with chronic recurrent vertigo have no identifiable cause, no progression of the disorder, and no other neurologic or auditory signs. Many families have multiple affected individuals, suggesting familial transmission of the disorder with moderate to high penetrance (summary by Lee et al., 2006). (193007) (Updated 20-May-2021)

MalaCards based summary : Vertigo, Benign Recurrent, also known as vestibulopathy, familial, is related to vertigo, benign recurrent, 2 and pathologic nystagmus, and has symptoms including vertigo, vertigo/dizziness and cupulolithiasis. An important gene associated with Vertigo, Benign Recurrent is BRV2 (Vertigo, Benign Recurrent, 2). The drugs Calcium carbonate and Vitamin D have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and spinal cord, and related phenotypes are vertigo and gait imbalance

Related Diseases for Vertigo, Benign Recurrent

Diseases in the Vertigo, Benign Recurrent family:

Vertigo, Benign Recurrent, 2

Diseases related to Vertigo, Benign Recurrent via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Related Disease Score Top Affiliating Genes
1 vertigo, benign recurrent, 2 11.5
2 pathologic nystagmus 10.7
3 migraine with or without aura 1 10.2
4 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.2
5 meniere disease 10.2
6 sensorineural hearing loss 10.2
7 vestibular neuronitis 10.2
8 benign paroxysmal positional nystagmus 10.2
9 neuritis 10.1
10 peripheral vertigo 10.1
11 sudden sensorineural hearing loss 10.1
12 head injury 10.1
13 branchiootic syndrome 1 10.0
14 headache 10.0
15 whiplash 10.0
16 pertussis 9.9
17 tetanus 9.9
18 diphtheria 9.9
19 diarrhea 9.9
20 gastroenteritis 9.9
21 poliomyelitis 9.9
22 haemophilus influenzae 9.9
23 hashimoto thyroiditis 9.8
24 motion sickness 9.8
25 osteoporosis 9.8
26 otitis media 9.8
27 hutterite cerebroosteonephrodysplasia syndrome 9.8
28 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 9.8
29 ocular motor apraxia 9.8
30 stroke, ischemic 9.8
31 bone mineral density quantitative trait locus 8 9.8
32 bone mineral density quantitative trait locus 15 9.8
33 covid-19 9.8
34 suppurative otitis media 9.8
35 goiter 9.8
36 hypothyroidism 9.8
37 labyrinthitis 9.8
38 hyperuricemia 9.8
39 lipid metabolism disorder 9.8
40 mood disorder 9.8
41 vestibular disease 9.8
42 thyroid gland disease 9.8
43 thyroiditis 9.8
44 hyperthyroidism 9.8
45 neuronitis 9.8
46 chronic fatigue syndrome 9.8
47 otitis externa 9.8
48 48,xyyy 9.8
49 myalgic encephalomyelitis/chronic fatigue syndrome 9.8
50 back pain 9.8

Comorbidity relations with Vertigo, Benign Recurrent via Phenotypic Disease Network (PDN):


Anxiety Basilar Artery Insufficiency
Esophagitis Hypertension, Essential
Hypothyroidism Intermediate Coronary Syndrome
Labyrinthitis Transient Cerebral Ischemia
Vertebral Artery Insufficiency

Graphical network of the top 20 diseases related to Vertigo, Benign Recurrent:



Diseases related to Vertigo, Benign Recurrent

Symptoms & Phenotypes for Vertigo, Benign Recurrent

Human phenotypes related to Vertigo, Benign Recurrent:

31
# Description HPO Frequency HPO Source Accession
1 vertigo 31 HP:0002321
2 gait imbalance 31 HP:0002141

Symptoms via clinical synopsis from OMIM®:

57 (Updated 20-May-2021)
Neurologic Central Nervous System:
gait imbalance
vertigo, episodic (onset in second or third decade)
vestibulopathy, bilateral, progressive (onset in fourth or fifth decade)
oscillopsia

Head And Neck Ears:
vertigo, episodic
vestibulopathy, bilateral, progressive
no hearing loss

Clinical features from OMIM®:

193007 (Updated 20-May-2021)

UMLS symptoms related to Vertigo, Benign Recurrent:


vertigo; vertigo/dizziness; cupulolithiasis

Drugs & Therapeutics for Vertigo, Benign Recurrent

Drugs for Vertigo, Benign Recurrent (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 41)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Calcium carbonate Approved, Investigational Phase 4 471-34-1
2
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
3
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 6221 5280795
4 Gastrointestinal Agents Phase 4
5 Trace Elements Phase 4
6 Nutrients Phase 4
7 Micronutrients Phase 4
8 Vitamins Phase 4
9 Calciferol Phase 4
10 Hormones Phase 4
11 Antacids Phase 4
12 Anti-Ulcer Agents Phase 4
13 Calcium Supplement Phase 4
14 Calcium, Dietary Phase 4
15
Calcium Nutraceutical Phase 4 7440-70-2 271
16
Lorazepam Approved 846-49-1 3958
17
Meclizine Approved 569-65-3 4034
18
Ondansetron Approved 99614-02-5 4595
19
Diphenhydramine Approved, Investigational 147-24-0, 58-73-1 3100
20
Diazepam Approved, Illicit, Investigational, Vet_approved 439-14-5 3016
21
Histamine Approved, Investigational 51-45-6, 75614-87-8 774
22
Promethazine Approved, Investigational 60-87-7 4927
23
Betahistine Approved, Investigational 5638-76-6 2366
24 Kava Approved, Investigational, Nutraceutical 9000-38-8
25 Vasodilator Agents
26 Antiemetics
27 Hypnotics and Sedatives
28 Psychotropic Drugs
29 Anesthetics
30 Neurotransmitter Agents
31 GABA Modulators
32 Anti-Allergic Agents
33 Anesthetics, Local
34 Antipsychotic Agents
35 Anticonvulsants
36 Histamine Antagonists
37
Histamine Phosphate 51-74-1 65513
38 Dermatologic Agents
39 Anti-Anxiety Agents
40 Histamine H1 Antagonists
41
Serotonin Investigational, Nutraceutical 50-67-9 5202

Interventional clinical trials:

(show all 38)
# Name Status NCT ID Phase Drugs
1 Efficacy of Vitamin D and Calcium Supplementation on the Prevention of Recurrences in Benign Paroxysmal Positional Vertigo: A Prospective Multicenter Randomized Trial Completed NCT02031692 Phase 4 400IU cholecalciferol and 500mg of elemental calcium as calcium carbonate
2 Randomized Multicenter Study of Treatment of Horizontal Canal Benign Paroxysmal Positional Vertigo Completed NCT00810641 Phase 3
3 Treatment of Geotropic Horizontal Canal Benign Paroxysmal Positional Vertigo; Randomized Controlled Trial of Barbeque Rotation and Gufoni Maneuver Completed NCT01366430 Phase 3
4 The Effectiveness Comparison of Three Different Methods for the Treatment of Posterior Semicircular Canal Benign Paroxysmal Positional Vertigo: Prospective, Double Blinded, Randomized, Multicenter Clinical Trial Completed NCT02029508 Phase 3
5 Treatment of Benign Paroxysmal Positional Vertigo With the Canalith Repositioning Procedure in Family Practice: A Randomized Controlled Trial Completed NCT00182273 Phase 3
6 Visual Feedback Goggle For The Treatment Of Benign Paroxysmal Positional Vertigo in a Randomized Single-Blind Study Unknown status NCT00729885 Phase 1, Phase 2
7 Treatments for Benign Paroxysmal Positional Vertigo (BPPV) Completed NCT00000359 Phase 2
8 Treatment of Apogeotropic Horizontal Canal Benign Paroxysmal Positional Vertigo Completed NCT02046980 Phase 2
9 A Double Blinded Randomized Control Trial (RCT) to Evaluate the Effectiveness of Vitamin D Treatment in Lowering the Recurrence Rate of Benign Paroxysmal Positional Vertigo (BPPV) in Older Patients Not yet recruiting NCT04578470 Phase 2 Vitamin D;Placebo
10 Randomized Controlled Trials for Treatment of Benign Paroxysmal Positional Vertigo Unknown status NCT01822002
11 Inactivity, Balance Problems and Fall Risk in Institutionalized Frail Elderly: What is the Impact of Benign Paroxysmal Positional Vertigo (BPPV) and Treatment Effectiveness? Unknown status NCT02905292
12 Efficacy of Postural Restriction in Treating Benign Paroxysmal Positional Vertigo Unknown status NCT02475239
13 The Effect of Vestibular Exercise, With or Without Medication, in Managing Residual Dizziness After Successful Repositioning Maneuvers in Patients With Benign Paroxysmal Positional Vertigo Unknown status NCT03624283 Betahistine
14 Clinical Aspects of Patients With Benign Paroxysmal Positional Vertigo (BPPV) and Migraine Completed NCT02615314
15 Comparison of Home-Based Modified Self-Epley Manoeuvre and Brandt-Daroff Exercise on the Posterior Canal Benign Paroxysmal Positional Vertigo Symptoms: A Randomized Single-Blind Controlled Trial Completed NCT03230513
16 Partnered Implementation of Evidence Based Best Care Practice for Benign Paroxysmal Positional Vertigo: A Stepped Wedge, Randomized Controlled Clinical Trial Completed NCT02809599
17 Can Benign Paroxysmal Positional Vertigo (BPPV) be Treated Faster and More Efficiently by Using a Mechanical Rotational Chair Compared to the Traditional Manual Repositioning Maneuvers? Completed NCT03871413
18 A Randomized Trial to Evaluate Resolution of Symptoms Using Vestibular Rehab Versus Conventional Therapy in Patients Presenting to the Emergency Department (ED) With Diagnosis of Benign Paroxysmal Positional Vertigo (BPPV) Completed NCT00641797 Meclizine;Lorazepam;Diphenhydramine;Ondansetron
19 Evaluation of the Otolithic Organs Function in Patients Suffering From Benign Paroxysmal Positional Vertigo (BPPV) by Vestibular Evoked Myogenic Potentials (VEMP). Completed NCT01004913
20 The Cardiac Autonomic Control System Response to Vestibular Stimulation in Subjects With and Without BPPV Completed NCT03867019
21 Effectiveness of the Epley Maneuver Versus Vestibular Exercises in the Treatment of Benign Paroxysmal Positional Vertigo (BPPV) Completed NCT04715282
22 Comparison of Half-Somersault Exercise With Brandt-Daroff Exercise in Patients With Posterior Canal Benign Paroxysmal Positional Vertigo: A Randomized Clinical Trial Completed NCT04469309
23 Effectiveness of Osteopathic Manipulative Treatment (OMT) and Vestibular Rehabilitation Therapy (VRT) Alone or in Combination on Balance and Visual Function in Individuals With Vertigo and Somatic Dysfunction Completed NCT01529151
24 Randomized Multicenter Study of Benign Paroxysmal Positional Vertigo Treatment in Biaxial Rotational Chair Completed NCT01905800
25 Effectiveness of the Epley Manoeuvre Performed in Primary Care to Treat Posterior Canal Benign Paroxysmal Positional Vertigo Completed NCT01969513
26 Effect of the Cranial Osteopathic Techniques on the Symptoms of Benign Paroxysmal Positional Vertigo Completed NCT03854084
27 Objective Examination and Rehabilitation Treatment of Patients With BPPV Completed NCT04367194
28 Comparison of the Treatment Outcomes of Posterior Canal Benign Paroxysmal Positional Vertigo (BPPV) With Canalith Repositioning Procedure (CRP): Single Versus Multiple Cycles Recruiting NCT02701218
29 Which Repositional Maneuver is the Most Successful When Treating Lateral and Posterior Benign Paroxysmal Positional Vertigo With the TRV Repositional Chair? Recruiting NCT03541018
30 Production of a Device to Obtain Continuous Ambulatory Vestibular Assessment (CAVA) - Dizziness Trial Recruiting NCT04026516
31 Efficacy of a New Type of Mechanical Rotational Chair (ROTUNDUM) in Treating BPPV Recruiting NCT04147156
32 Benign Paroxysmal Positional Vertigo (BPPV) Training for Sports Medicine Providers in a Pediatric Concussion Program Not yet recruiting NCT03425786
33 Virtual Reality Epley Maneuver System (VREMS) for Treatment of Benign Paroxysmal Positional Vertigo Not yet recruiting NCT04436783
34 Evaluation of the Prevalence of BPPV and Longterm Effects of Its Therapy in Retirement Homes Not yet recruiting NCT03643354
35 Epley Manoeuvre for Posterior Semi-circular Canal Benign Paroxysmal Positional Vertigo in People With Multiple Sclerosis: Protocol of a Randomized Controlled Trial Not yet recruiting NCT04578262
36 Efficacy of a Mechanical Chair for Treatment of Benign Paroxysmal Positional Vertigo (BPPV) Terminated NCT03161470
37 Epley Maneuver vs. Semont Maneuver for Benign Paroxysmal Positional Vertigo (BPPV): Evaluating Treatment Effectiveness by Postural Stability - a Double Blinded Randomized Controlled Trial. Withdrawn NCT00978809
38 The Liberatory Maneuver for the Treatment of Benign Paroxysmal Positional Vertigo: A Randomized Controlled Trial Withdrawn NCT01008124

Search NIH Clinical Center for Vertigo, Benign Recurrent

Genetic Tests for Vertigo, Benign Recurrent

Anatomical Context for Vertigo, Benign Recurrent

MalaCards organs/tissues related to Vertigo, Benign Recurrent:

40
Bone, Brain, Spinal Cord, Thyroid

Publications for Vertigo, Benign Recurrent

Articles related to Vertigo, Benign Recurrent:

# Title Authors PMID Year
1
A genome-wide linkage scan of familial benign recurrent vertigo: linkage to 22q12 with evidence of heterogeneity. 57
16330481 2006
2
Suggestive linkage to chromosome 6q in families with bilateral vestibulopathy. 57
15623703 2004
3
Familial early-onset progressive vestibulopathy without hearing impairment. 57
12953770 2003
4
Familial benign recurrent vertigo. 57
11343320 2001
5
The familial incidence of benign paroxysmal positional vertigo. 57
9870618 1998
6
Familial vestibulopathy: a new dominantly inherited syndrome. 57
8290084 1994
7
Dandy's syndrome. 57
7457577 1980
8
Diagnosis and initiating treatment for peripheral system disorders: imbalance and dizziness with normal hearing. 61
10815037 2000

Variations for Vertigo, Benign Recurrent

Expression for Vertigo, Benign Recurrent

Search GEO for disease gene expression data for Vertigo, Benign Recurrent.

Pathways for Vertigo, Benign Recurrent

GO Terms for Vertigo, Benign Recurrent

Sources for Vertigo, Benign Recurrent

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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