BRV
MCID: VRT013
MIFTS: 37

Vertigo, Benign Recurrent (BRV)

Categories: Genetic diseases

Aliases & Classifications for Vertigo, Benign Recurrent

MalaCards integrated aliases for Vertigo, Benign Recurrent:

Name: Vertigo, Benign Recurrent 58
Vestibulopathy, Familial 58 13
Vertigo, Benign Paroxysmal Positional; Bppv 58
Vertigo, Benign Paroxysmal Positional 58
Benign Paroxysmal Positional Vertigo 74
Bppv 58
Brv 58

Characteristics:

OMIM:

58
Inheritance:
autosomal dominant

Miscellaneous:
slowly progressive disorder
acetazolamide may benefit attacks of vertigo


HPO:

33
vertigo, benign recurrent:
Onset and clinical course slow progression
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 58 193007
MedGen 43 C0155502
UMLS 74 C0155502

Summaries for Vertigo, Benign Recurrent

OMIM : 58 Benign recurrent vertigo (BRV), also known as benign paroxysmal positional vertigo (BPPV), is a common disorder affecting up to 2% of the adult population. The majority of individuals with chronic recurrent vertigo have no identifiable cause, no progression of the disorder, and no other neurologic or auditory signs. Many families have multiple affected individuals, suggesting familial transmission of the disorder with moderate to high penetrance (summary by Lee et al., 2006). (193007)

MalaCards based summary : Vertigo, Benign Recurrent, also known as vestibulopathy, familial, is related to vertigo, benign recurrent, 2 and benign paroxysmal positional nystagmus, and has symptoms including vertigo, vertigo/dizziness and cupulolithiasis. An important gene associated with Vertigo, Benign Recurrent is BRV2 (Vertigo, Benign Recurrent, 2). The drugs Calcium Carbonate and Vitamin D3 have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and thyroid, and related phenotypes are gait imbalance and vertigo

Related Diseases for Vertigo, Benign Recurrent

Graphical network of the top 20 diseases related to Vertigo, Benign Recurrent:



Diseases related to Vertigo, Benign Recurrent

Symptoms & Phenotypes for Vertigo, Benign Recurrent

Human phenotypes related to Vertigo, Benign Recurrent:

33
# Description HPO Frequency HPO Source Accession
1 gait imbalance 33 HP:0002141
2 vertigo 33 HP:0002321

Symptoms via clinical synopsis from OMIM:

58
Neurologic Central Nervous System:
gait imbalance
vertigo, episodic (onset in second or third decade)
vestibulopathy, bilateral, progressive (onset in fourth or fifth decade)
oscillopsia

Head And Neck Ears:
vertigo, episodic
vestibulopathy, bilateral, progressive
no hearing loss

Clinical features from OMIM:

193007

UMLS symptoms related to Vertigo, Benign Recurrent:


vertigo, vertigo/dizziness, cupulolithiasis

Drugs & Therapeutics for Vertigo, Benign Recurrent

Drugs for Vertigo, Benign Recurrent (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 52)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Calcium Carbonate Approved, Investigational Phase 4 471-34-1
2
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 5280795 6221
3
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
4
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
5
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
6 Calciferol Phase 4
7 Vitamins Phase 4
8 Trace Elements Phase 4
9 Ergocalciferols Phase 4
10 Micronutrients Phase 4
11 Bone Density Conservation Agents Phase 4
12 Gastrointestinal Agents Phase 4,Not Applicable
13 Vitamin D2 Phase 4
14 Calcium Supplement Phase 4
15 Anti-Ulcer Agents Phase 4
16 Antacids Phase 4
17 Hormones Phase 4
18 Nutrients Phase 4
19 Calcium, Dietary Phase 4
20
Histamine Approved, Investigational Not Applicable 51-45-6 774
21
Lorazepam Approved Not Applicable 846-49-1 3958
22
Promethazine Approved, Investigational Not Applicable 60-87-7 4927
23
Meclizine Approved Not Applicable 569-65-3 4034
24
Diphenhydramine Approved, Investigational Not Applicable 147-24-0, 58-73-1 3100
25
Ondansetron Approved Not Applicable 99614-02-5 4595
26
Diazepam Approved, Illicit, Investigational, Vet_approved Not Applicable 439-14-5 3016
27
Betahistine Approved, Investigational Not Applicable 5638-76-6 2366
28 Autonomic Agents Not Applicable
29 Antipsychotic Agents Not Applicable
30 Central Nervous System Depressants Not Applicable
31 GABA Modulators Not Applicable
32 Antiemetics Not Applicable
33 Dermatologic Agents Not Applicable
34
Histamine Phosphate Not Applicable 51-74-1 65513
35 Anesthetics Not Applicable
36 Anesthetics, Local Not Applicable
37 GABA Agents Not Applicable
38 Serotonin Antagonists Not Applicable
39 Histamine H1 Antagonists Not Applicable
40 Peripheral Nervous System Agents Not Applicable
41 Neurotransmitter Agents Not Applicable
42 Anti-Allergic Agents Not Applicable
43 Histamine Antagonists Not Applicable
44 Psychotropic Drugs Not Applicable
45 Antipruritics Not Applicable
46 Hypnotics and Sedatives Not Applicable
47 Anti-Anxiety Agents Not Applicable
48 Tranquilizing Agents Not Applicable
49 Serotonin Agents Not Applicable
50 Anticonvulsants Not Applicable

Interventional clinical trials:

(show all 36)
# Name Status NCT ID Phase Drugs
1 Efficacy of Vitamin D and Calcium Supplementation on the Prevention of Recurrences in BPPV Completed NCT02031692 Phase 4 400IU cholecalciferol and 500mg of elemental calcium as calcium carbonate
2 The Treatment of Posterior Semicircular Canal Benign Paroxysmal Positional Vertigo Completed NCT02029508 Phase 3
3 Treatment of Geotropic Horizontal Canal Benign Paroxysmal Positional Vertigo Completed NCT01366430 Phase 3
4 Treatment of Apogeotropic Horizontal Canal Benign Paroxysmal Positional Vertigo Completed NCT00810641 Phase 3
5 Canalith Repositioning Procedure for BPPV in Primary Care Completed NCT00182273 Phase 3
6 Visual Feedback Goggle for Positional Vertigo Treatment Unknown status NCT00729885 Phase 1, Phase 2
7 Treatment of Apogeotropic Horizontal Canal Benign Paroxysmal Positional Vertigo Completed NCT02046980 Phase 2
8 Treatments for Benign Paroxysmal Positional Vertigo (BPPV) Completed NCT00000359 Phase 2
9 Efficacy of Postural Restriction in Treating Benign Paroxysmal Positional Vertigo Unknown status NCT02475239 Not Applicable
10 Treatment of Posterior Canal Type of Benign Paroxysmal Positional Vertigo Unknown status NCT01822002 Not Applicable
11 The Liberatory Maneuver for the Treatment of Benign Paroxysmal Positional Vertigo (BPPV) Unknown status NCT01008124 Not Applicable
12 Comparison of Home-Based Exercise on the Posterior Canal Benign Paroxysmal Positional Vertigo Symptoms Completed NCT03230513 Not Applicable
13 Cranial Osteopathic Techniques on the Symptoms of Benign Paroxysmal Positional Vertigo Completed NCT03854084 Not Applicable
14 Evidence Based Best Care Practice for Benign Paroxysmal Positional Vertigo Completed NCT02809599 Not Applicable
15 Treating Benign Paroxysmal Positional Vertigo (BPPV) in ED Patients Completed NCT00641797 Not Applicable Meclizine;Lorazepam;Diphenhydramine;Ondansetron
16 Vestibular Evoked Myogenic Potentials in Benign Paroxysmal Positional Vertigo (VEMP in BPPV) Completed NCT01004913
17 BPPV Treatment in Biaxial Rotational Chair Completed NCT01905800 Not Applicable
18 Clinical Aspects of Patients With Benign Paroxysmal Positional Vertigo (BPPV) and Migraine Completed NCT02615314
19 Effectiveness of the Epley Manoeuvre Performed in Primary Care to Treat Benign Paroxysmal Positional Vertigo Completed NCT01969513 Not Applicable
20 Effectiveness of Osteopathic Manipulative Treatment (OMT) and Vestibular Rehabilitation Therapy (VRT) in Individuals With Vertigo Completed NCT01529151 Not Applicable
21 To Study the Characteristics of Different Types of Vertigo in Patients Attending the Ear Nose & Throat (ENT) Clinics. Completed NCT02213120
22 Osteotome Sinus Floor Elevation With or Without Grafting Completed NCT01619956 Not Applicable
23 Sinus Lift: Saving Time and Reducing Morbidity Completed NCT02415946 Not Applicable
24 Different Treatments With the TRV Reposition Chair Recruiting NCT03541018 Not Applicable
25 BPPV With CRP: Single Versus Multiple Cycles Recruiting NCT02701218 Not Applicable
26 Inactivity, Balance Problems and Fall Risk in Institutionalized Frail Elderly Recruiting NCT02905292
27 Interventions for Residual Dizziness After Successful Repositioning Maneuvers in Patients With BPPV Recruiting NCT03624283 Not Applicable Betahistine
28 3D Model of Posterior Membranous Labyrinth of the Inner Ear Recruiting NCT03295929
29 Acute Video-oculography for Vertigo in Emergency Rooms for Rapid Triage (AVERT) Recruiting NCT02483429 Not Applicable
30 Clinical Evaluation of Two Types of Transalveolar Sinus Floor Elevation Recruiting NCT03445039 Not Applicable
31 Efficacy of a Mechanical Chair for Treatment of Benign Paroxysmal Positional Vertigo (BPPV) Enrolling by invitation NCT03161470 Not Applicable
32 TRV-chair vs Manual Repositioning Maneuver in Treatment of Benign Paroxysmal Positional Vertigo Enrolling by invitation NCT03871413 Not Applicable
33 Benign Paroxysmal Positional Vertigo (BPPV) Training for Sports Medicine Providers in a Pediatric Concussion Program Not yet recruiting NCT03425786 Not Applicable
34 Evaluation of the Prevalence of BPPV and Longterm Effects of Its Therapy Using the Rotundum Device in Retirement Homes Not yet recruiting NCT03643354 Not Applicable
35 The Influence of Vestibular Stimulation on Cardiac Autonomic Control System in Subjects With and Without BPPV Not yet recruiting NCT03867019
36 Effects of Physical Treatment on Postural Stability in Benign Paroxysmal Positional Vertigo (BPPV) Patients Withdrawn NCT00978809 Not Applicable

Search NIH Clinical Center for Vertigo, Benign Recurrent

Genetic Tests for Vertigo, Benign Recurrent

Anatomical Context for Vertigo, Benign Recurrent

MalaCards organs/tissues related to Vertigo, Benign Recurrent:

42
Testes, Brain, Thyroid, Spinal Cord, Cerebellum

Publications for Vertigo, Benign Recurrent

Articles related to Vertigo, Benign Recurrent:

(show top 50) (show all 864)
# Title Authors Year
1
Effects of treatment on anxiety levels among patients with benign paroxysmal positional vertigo. ( 30666439 )
2019
2
Otolith dysfunction in recurrent benign paroxysmal positional vertigo after mild traumatic brain injury. ( 30714506 )
2019
3
Increased risk of benign paroxysmal positional vertigo in osteoporosis: a nationwide population-based cohort study. ( 30837524 )
2019
4
Idiopathic benign paroxysmal positional vertigo with persistent vertigo/dizziness sensation is associated with latent canal paresis, endolymphatic hydrops, and osteoporosis. ( 30042018 )
2019
5
Association Between Migraine and Benign Paroxysmal Positional Vertigo Among Adults in South Korea. ( 30676633 )
2019
6
Benign paroxysmal positional vertigo in children. ( 30220115 )
2019
7
Early experience with a multi-axial, whole body positioning system in the treatment of Benign Paroxysmal Positional Vertigo (BPPV). ( 30377044 )
2019
8
Effectiveness of the Epley manoeuvre in posterior canal benign paroxysmal positional vertigo: a randomised clinical trial in primary care. ( 30510098 )
2019
9
Increased Risk of Benign Paroxysmal Positional Vertigo in Patients With a History of Sudden Sensory Neural Hearing Loss: A Longitudinal Follow-up Study Using a National Sample Cohort. ( 30624405 )
2019
10
Clinical features of benign paroxysmal positional vertigo of the posterior semicircular canal. ( 30637105 )
2019
11
Analysis of cost and effectiveness of treatment in benign paroxysmal positional vertigo. ( 30681502 )
2019
12
Poor Treatment Outcomes Following Repositioning Maneuvers in Younger and Older Adults With Benign Paroxysmal Positional Vertigo: A Systematic Review and Meta-analysis. ( 30691621 )
2019
13
Diagnosis and treatment choices of suspected benign paroxysmal positional vertigo: current approach of general practitioners, neurologists, and ENT physicians. ( 30694376 )
2019
14
Correlations of Calcium Voltage-Gated Channel Subunit Alpha1 A (CACNA1A) Gene Polymorphisms with Benign Paroxysmal Positional Vertigo. ( 30710491 )
2019
15
Sitting Up Vertigo. Proposed Variant of Posterior Canal Benign Paroxysmal Positional Vertigo. ( 30807523 )
2019
16
Serum Vitamin D and Long-Term Outcomes of Benign Paroxysmal Positional Vertigo. ( 30813712 )
2019
17
Association Between Serum Uric Acid Levels and Benign Paroxysmal Positional Vertigo: A Systematic Review and Meta-Analysis of Observational Studies. ( 30828314 )
2019
18
Benign paroxysmal positional vertigo. ( 30828628 )
2019
19
Sitting Up Vertigo. Proposed Variant of Posterior Canal Benign Paroxysmal Positional Vertigo. ( 30870365 )
2019
20
Difference in Serum Levels of Vitamin D Between Canalolithiasis and Cupulolithiasis of the Horizontal Semicircular Canal in Benign Paroxysmal Positional Vertigo. ( 30881337 )
2019
21
Impaired Calcium Metabolism in Benign Paroxysmal Positional Vertigo: A Topical Review. ( 30883492 )
2019
22
Effect of Epley, Semont Maneuvers and Brandt-Daroff Exercise on Quality of Life in Patients with Posterior Semicircular Canal Benign Paroxysmal Positional Vertigo (PSCBPPV). ( 30906723 )
2019
23
Risk of benign paroxysmal positional vertigo in patients with depressive disorders: a nationwide population-based cohort study. ( 30928959 )
2019
24
Investigation of self-reported dizziness in the elderly when lying down or turning over in bed, and possible benign paroxysmal positional vertigo. ( 30929651 )
2019
25
Benign Paroxysmal Positional Vertigo. ( 30947198 )
2019
26
Identification of Factors Related to Cases of Benign Paroxysmal Positional Vertigo Refractory to Canalicular Repositioning Maneuvers and Evaluation of the Need for Magnetic Resonance Imaging in their Management: Retrospective Analysis of a Series of 176 Cases. ( 30956705 )
2019
27
Seasonality and solar radiation variation level in benign paroxysmal positional vertigo. ( 30957689 )
2019
28
Serum levels of 25-hydroxy vitamin D correlate with idiopathic benign paroxysmal positional vertigo. ( 30962270 )
2019
29
Diagnosis strategy and Yacovino maneuver for anterior canal-benign paroxysmal positional vertigo. ( 30963252 )
2019
30
Optimal reassessment time for treatment response in posterior canal benign paroxysmal positional vertigo. ( 30982972 )
2019
31
Association between bone mineral density and benign paroxysmal positional vertigo: a meta-analysis. ( 31030242 )
2019
32
Post-traumatic benign paroxysmal positional vertigo. ( 31048363 )
2019
33
Persistent Upbeat Positional Nystagmus in a Patient with Bilateral Posterior Canal Benign Paroxysmal Positional Vertigo. ( 31049238 )
2019
34
Reposition Chair Treatment Improves Subjective Outcomes in Refractory Benign Paroxysmal Positional Vertigo. ( 31058604 )
2019
35
A new treatment (the affected-ear-up 90° maneuver) for benign paroxysmal positional vertigo of the lateral semicircular canal. ( 31066612 )
2019
36
Developing a Diagnostic Decision Support System for Benign Paroxysmal Positional Vertigo Using a Deep-Learning Model. ( 31072056 )
2019
37
Caloric tests in clinical practice in benign paroxysmal positional vertigo. ( 31099297 )
2019
38
Incidence and Clinical Significance of Positional Downbeat Nystagmus in Posterior Canal Benign Paroxysmal Positional Vertigo. ( 29856161 )
2019
39
Otolithic damage study in patients with benign paroxysmal positional vertigo with vestibular evoked myogenic potentials. ( 29895391 )
2019
40
Aging Is a Risk Factor for Utricular Dysfunction in Idiopathic Benign Paroxysmal Positional Vertigo. ( 30559714 )
2018
41
Anxiety, Mood, and Personality Disorders in Patients with Benign Paroxysmal Positional Vertigo. ( 30042641 )
2018
42
Benign paroxysmal positional vertigo in patients after mild traumatic brain injury. ( 30058780 )
2018
43
Fourth ventricle ependymoma mimicking benign paroxysmal positional vertigo. ( 30104227 )
2018
44
Benign paroxysmal positional vertigo in spontaneous intracranial hypotension. ( 30052143 )
2018
45
Benign paroxysmal positional vertigo and osteoporosis. ( 30554357 )
2018
46
Subjective benign paroxysmal positional vertigo in patients with osteoporosis or migraine. ( 30482521 )
2018
47
Osteoporosis increases the risk of benign paroxysmal positional vertigo: a nested case-control study using a national sample cohort. ( 30511104 )
2018
48
The prevalence of benign paroxysmal positional vertigo in patients with osteoporosis. ( 30315360 )
2018
49
Analyses with the Video Head Impulse Test During the Canalith Repositioning Maneuver in Patients with Isolated Posterior Semicircular Canal Benign Paroxysmal Positional Vertigo. ( 30197804 )
2018
50
Anterior Canal benign paroxysmal positional Vertigo following surgical Management of superior canal dehiscence. ( 30224218 )
2018

Variations for Vertigo, Benign Recurrent

Expression for Vertigo, Benign Recurrent

Search GEO for disease gene expression data for Vertigo, Benign Recurrent.

Pathways for Vertigo, Benign Recurrent

GO Terms for Vertigo, Benign Recurrent

Sources for Vertigo, Benign Recurrent

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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