MCID: VSC005
MIFTS: 50

Vesicoureteral Reflux

Categories: Fetal diseases, Genetic diseases, Nephrological diseases, Rare diseases
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Aliases & Classifications for Vesicoureteral Reflux

MalaCards integrated aliases for Vesicoureteral Reflux:

Name: Vesicoureteral Reflux 11 28 53 5 14 16 75
Vesico-Ureteral Reflux 11 43

Classifications:



External Ids:

Disease Ontology 11 DOID:9620
ICD9CM 34 593.7
MeSH 43 D014718
NCIt 49 C84467
SNOMED-CT 68 197811007
ICD10 31 N13.7
UMLS 71 C0042580

Summaries for Vesicoureteral Reflux

Disease Ontology: 11 A ureteral disease characterized by backward flow of urine from the urinary bladder into the ureter.

MalaCards based summary: Vesicoureteral Reflux, also known as vesico-ureteral reflux, is related to papillorenal syndrome and familial vesicoureteral reflux, and has symptoms including dysuria and urgency of micturition. An important gene associated with Vesicoureteral Reflux is EBF3 (EBF Transcription Factor 3), and among its related pathways/superpathways are ACE Inhibitor Pathway, Pharmacodynamics and Angiotensin II receptor type 1 pathway. The drugs Levoleucovorin and Trimethoprim have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, kidney and smooth muscle, and related phenotype is adipose tissue.

Wikipedia: 75 Vesicoureteral reflux (VUR), also known as vesicoureteric reflux, is a condition in which urine flows... more...

Related Diseases for Vesicoureteral Reflux

Diseases in the Vesicoureteral Reflux family:

Vesicoureteral Reflux 1 Vesicoureteral Reflux 2
Vesicoureteral Reflux 3 Vesicoureteral Reflux 4
Vesicoureteral Reflux 5 Vesicoureteral Reflux 6
Vesicoureteral Reflux 7 Vesicoureteral Reflux 8
Familial Vesicoureteral Reflux

Diseases related to Vesicoureteral Reflux via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 299)
# Related Disease Score Top Affiliating Genes
1 papillorenal syndrome 33.3 UPK3A ROBO2 PAX2
2 familial vesicoureteral reflux 33.0 TNXB ROBO2
3 urinary tract infection 32.7 UPK3A UMOD EBF3
4 cakut 32.5 UPK3A UMOD TNXB ROBO2 PAX2 KAT6B
5 congenital anomalies of kidney and urinary tract 2 32.5 UPK3A UMOD ROBO2 PAX2 AGTR2
6 hydronephrosis 32.2 UPK3A PAX2 C12orf57 AGTR2
7 ureterocele 31.7 ROBO2 PAX2
8 chronic kidney disease 31.6 UMOD PAX2 AGTR1 AGT
9 urinary tract obstruction 31.6 UPK3A UMOD PAX2 AGTR1
10 end stage renal disease 31.5 TNXB ROBO2 PAX2
11 renal hypoplasia 31.4 ROBO2 PAX2 KAT6B
12 multicystic dysplastic kidney 31.4 PAX2 AGTR2 AGTR1 AGT
13 renal hypodysplasia/aplasia 1 31.2 UPK3A ROBO2 PAX2 AGTR2
14 renovascular hypertension 30.6 AGTR2 AGTR1 AGT
15 oligohydramnios 30.5 PAX2 AGTR1 AGT
16 acute cystitis 30.5 UPK3A UMOD
17 anuria 30.3 AGTR1 AGT
18 glass syndrome 30.2 NIPBL MED13L
19 vesicoureteral reflux 2 11.6
20 vesicoureteral reflux 3 11.6
21 vesicoureteral reflux 1 11.6
22 vesicoureteral reflux 8 11.6
23 urofacial syndrome 1 11.4
24 vesicoureteral reflux 4 11.4
25 vesicoureteral reflux 5 11.4
26 vesicoureteral reflux 6 11.4
27 vesicoureteral reflux 7 11.4
28 vesicoureteral reflux, x-linked 11.4
29 duane-radial ray syndrome 11.4
30 renal hypodysplasia/aplasia 3 11.3
31 bladder dysfunction, autonomic, with impaired pupillary reflex and secondary cakut 11.3
32 palmer pagon syndrome 11.3
33 acrorenal syndrome 11.1
34 ectrodactyly and ectodermal dysplasia without cleft lip/palate 11.1
35 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 1 11.1
36 hand-foot-genital syndrome 11.1
37 acrorenal syndrome, autosomal recessive 11.1
38 multiple congenital anomalies-hypotonia-seizures syndrome 2 11.1
39 congenital anomalies of kidney and urinary tract 1 11.1
40 brain malformations with or without urinary tract defects 11.1
41 urofacial syndrome 2 11.1
42 megacystis-megaureter syndrome 11.1
43 pyelonephritis 11.1
44 neurogenic bladder 10.9
45 urinary tract infections, recurrent 10.9
46 ureteral obstruction 10.8
47 acute pyelonephritis 10.8
48 posterior urethral valves 10.8
49 bowel dysfunction 10.7
50 cystitis 10.7

Graphical network of the top 20 diseases related to Vesicoureteral Reflux:



Diseases related to Vesicoureteral Reflux

Symptoms & Phenotypes for Vesicoureteral Reflux

UMLS symptoms related to Vesicoureteral Reflux:


dysuria; urgency of micturition

MGI Mouse Phenotypes related to Vesicoureteral Reflux:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 adipose tissue MP:0005375 9.17 AFAP1L2 AGT AGTR1 AGTR2 KAT6B NIPBL

Drugs & Therapeutics for Vesicoureteral Reflux

Drugs for Vesicoureteral Reflux (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Levoleucovorin Approved, Experimental, Investigational Phase 4 68538-85-2, 58-05-9, 73951-54-9 149436 6006
2
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
3
Sulfamethoxazole Approved Phase 4 723-46-6 5329
4
Nitrofurantoin Approved, Vet_approved Phase 4 67-20-9 5353830
5
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
6 Folic Acid Antagonists Phase 4
7 Folate Phase 4
8 Anti-Bacterial Agents Phase 4
9 Vitamin B9 Phase 4
10 Anti-Infective Agents Phase 4
11 Antiprotozoal Agents Phase 4
12 Antiparasitic Agents Phase 4
13 Vitamin B Complex Phase 4
14 Antimalarials Phase 4
15 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4
16 Antibiotics, Antitubercular Phase 4
17 Cytochrome P-450 Enzyme Inhibitors Phase 4
18
Cefixime Approved, Investigational Phase 3 79350-37-1 5362065
19
Clavulanic acid Approved, Vet_approved Phase 3 58001-44-8 5280980
20 Amoxicillin-Potassium Clavulanate Combination Phase 3
21 beta-Lactamase Inhibitors Phase 3
22 Pharmaceutical Solutions Phase 1, Phase 2
23
Midazolam Approved, Illicit 59467-70-8 4192
24 Adjuvants, Immunologic
25 Viscosupplements
26 Immunologic Factors
27 Protective Agents
28 Cephalosporins
29 Anesthetics
30 Anti-Anxiety Agents
31 Neurotransmitter Agents
32 Psychotropic Drugs
33 Anesthetics, Intravenous
34 Anesthetics, General
35 Hypnotics and Sedatives
36 GABA Modulators

Interventional clinical trials:

(show all 27)
# Name Status NCT ID Phase Drugs
1 A Prospective Study Comparing the Success Rate of Injection of Dextranomer /Hyaluronic Acid (DefluxR) Versus Polyacrylate Polyalcohol (VantrisR) for Treatment of Bilateral Similar Grade Vesicoureteral Reflux in Children Unknown status NCT02271035 Phase 4 Deflux;Vantris
2 Antibiotic Prophylaxis After Acute Pyelonephritis for Prevention of Urinary Tract Infections in Children With Vesico-Ureteral Reflux. Completed NCT00382343 Phase 4 Sulfamethoxazole/trimethoprim
3 Phase III Study of Chondrocyte Alginate Gel Suspension in Pediatric Patients With Vesicoureteral Reflux Unknown status NCT00004487 Phase 3 chondrocyte-alginate gel suspension
4 Evaluation of the Efficiency of Autologous Adipocytes Graft in Endoscopic Treatment in Vesico-Renal Reflux in Children Unknown status NCT00367159 Phase 3
5 Randomized Intervention for Children With Vesicoureteral Reflux (RIVUR) Completed NCT00405704 Phase 3 Trimethoprim-Sulfamethoxazole;Placebo
6 Antibiotic Prophylaxis and Renal Damage In Congenital Abnormalities of the Kidney and Urinary Tract Active, not recruiting NCT02021006 Phase 3 nitrofurantoin;Amoxicillin-Potassium Clavulanate Combination;Trimethoprim/sulfamethoxazole;Cefixime
7 A Randomized Controlled Trial of Antibiotic Prophylaxis in Children With Pyelonephritis in the Abscence of Vesicoureteral Reflux Withdrawn NCT00752375 Phase 3 Trimethoprim Sulfamethoxazole;placebo
8 Contrast Enhanced Voiding Urosonography (ceVUS) With the Intravesical Administration of the Ultrasound Contrast Agent OPTISON TM (Trademark) for Vesicoureteral Reflux Detection and Urethral Imaging in Children. Completed NCT02204917 Phase 1, Phase 2 OPTISON
9 Contrast Enhanced Ultrasound for Evaluation of Reflux Nephropathy Completed NCT02786810 Phase 2 Sulfur hexafluoride type-a lipid microspheres
10 Radiation-Free Technique for Evaluating Renal Scarring (RAFTERS) Active, not recruiting NCT03653702 Phase 1 Lumason
11 The Effectiveness of Virtual Reality (VR) to Reduce Pain and Anxiety During Genitourinary (GU) Scans Unknown status NCT04251988
12 Efficacy of Endoscopic Subureteral Injection for Vesicoureteral Reflux in Adults With Decreased Bladder Compliance Completed NCT00815334
13 Tissue Bulking Agent -Polyacrylate Polyalcohol Copolymer for Endoscopic Correction of Vesicoureteral Reflux in Children: A Comparative Study Completed NCT01926353
14 Comparison of Subureteral Endoscopic Injection of Dextranomer/Hyaluronic Acid and Lich-Gregoir Ureteral Reimplantation In the Treatment of Pediatric Primary Vesicoureteral Reflux: Prospective Randomized Study Completed NCT04798443
15 Determination of Voiding Patterns of Children With Vesicoureteral Reflux Completed NCT00186199
16 Prospective Pediatric Vesicoureteral Reflux Surgery Database Completed NCT01373385
17 The Long Term Follow-Up Results Of The Direct Nipple Ureteroneocystostomy Technique: A Prospective Study Completed NCT01780493
18 DVD-Based Training Program in Self-Hypnosis for Children: A Randomized Clinical Trial Completed NCT01483105
19 Antimicrobial Prophylaxis in Children With Isolated Vesico-Ureteral Reflux. A Randomised Prospective Study of Continuous Low Dose of Trimethoprim-Sulfamethoxazole Versus Surveillance. Completed NCT00200616
20 Vesico-ureteral Reflux in a Contemporary Series of Spinal Cord Injury Patients With Neurogenic Lower Urinary Tract Dysfunction Completed NCT01297673
21 Study of Gut Microbiota Diversity in Children Aged 1-3 Years on Prolonged Antibiotic Prophylaxis for Grade 3 or Higher Vesicoureteral Reflux Compared With 2 Age-matched Control Groups Active, not recruiting NCT05319067
22 A Randomized, Double-Blind, Placebo-Controlled Study Examining the Efficacy of Oral Midazolam in Reducing Anxiety in Children Undergoing Voiding Cystourethrogram Terminated NCT00894465 midazolam;placebo
23 Parent Education and Medical Play: A Comparison of Psychological Preparation Strategies for Voiding Cystourethrogram Terminated NCT01578291
24 A Randomized Trial of Endoscopic vs. Open Anti-Reflux Surgery For Treatment of Low-Grade Vesicoureteral Reflux: Surgical Treatment of Reflux: Endoscopic vs. Traditional CHoices (STRETCH) Study Withdrawn NCT00830479
25 Ultrasound Based Acoustic Radiation Force Impulse (ARFI)Shear Wave Velocity Imaging (SVI)of the Kidneys in Pediatric Patients With Vesicoureteral Reflux Withdrawn NCT01781819
26 Bacterial and Host Genetic Risk Factors That Predispose Children to Acute Pyelonephritis and Renal Scarring Withdrawn NCT01137929
27 Clinical Applications of Contrast-Enhanced Ultrasonography in Pediatric Population - Intravesicle Administration Withdrawn NCT02986477

Search NIH Clinical Center for Vesicoureteral Reflux

Cochrane evidence based reviews: vesico-ureteral reflux

Genetic Tests for Vesicoureteral Reflux

Genetic tests related to Vesicoureteral Reflux:

# Genetic test Affiliating Genes
1 Vesicoureteral Reflux 28

Anatomical Context for Vesicoureteral Reflux

Organs/tissues related to Vesicoureteral Reflux:

MalaCards : Spinal Cord, Kidney, Smooth Muscle, Adipocyte, Neutrophil, Prostate, Testis

Publications for Vesicoureteral Reflux

Articles related to Vesicoureteral Reflux:

(show top 50) (show all 6311)
# Title Authors PMID Year
1
A homozygous missense variant in VWA2, encoding an interactor of the Fraser-complex, in a patient with vesicoureteral reflux. 62 5
29351342 2018
2
Whole-genome sequencing of patients with rare diseases in a national health system. 5
32581362 2020
3
Screening of vesicoureteral reflux in pediatric patients with kidney transplantation showing non-specific interstitial fibrosis and tubular atrophy with interstitial Tamm-Horsfall protein deposits in protocol allograft biopsy. 53 62
19594587 2009
4
Uroplakin III is not a major candidate gene for primary vesicoureteral reflux. 53 62
15523493 2005
5
The diagnostic role of urinary N-acetyl-beta-D-glucosaminidase (NAG) activity in the detection of renal tubular impairment. 53 62
16259316 2005
6
Renin-angiotensin system polymorphisms in Taiwanese primary vesicoureteral reflux. 53 62
15045574 2004
7
No pathogenic mutations in the uroplakin III gene of 25 patients with primary vesicoureteral reflux. 53 62
14713856 2004
8
Optic nerve dysplasia and renal insufficiency in a family with a novel PAX2 mutation, Arg115X: further ophthalmologic delineation of the renal-coloboma syndrome. 53 62
14566649 2003
9
Angiotensin II type 2 receptor gene is not responsible for familial vesicoureteral reflux. 53 62
12187255 2002
10
Renal-coloboma syndrome: a multi-system developmental disorder caused by PAX2 mutations. 53 62
10466411 1999
11
Homonucleotide expansion and contraction mutations of PAX2 and inclusion of Chiari 1 malformation as part of renal-coloboma syndrome. 53 62
10533062 1999
12
The prevalence of PAX2 mutations in patients with isolated colobomas or colobomas associated with urogenital anomalies. 53 62
9783702 1998
13
[Renal function in children with reflux nephropathy followed up more than 10 years after disappearance of vesicoureteral reflux: usefulness of alpha 1-microglobulin as a marker to predict the prognosis of these children]. 53 62
8969545 1996
14
Mutation of the PAX2 gene in a family with optic nerve colobomas, renal anomalies and vesicoureteral reflux. 53 62
7795640 1995
15
Urinary N-acetyl-beta-glucosaminidase as a screening technique for vesicoureteral reflux. 53 62
8154076 1994
16
[Studies on reflux nephropathy--renal tubular and glomerular damage evaluated by various urinary indices]. 53 62
7681890 1993
17
Urinary levels of renal tubular enzyme N-acetyl-beta-D-glucosaminidase in relation to grade of vesicoureteral reflux. 53 62
1861320 1991
18
Urinary Tamm-Horsfall protein excretion in patients with primary vesicoureteral reflux. 53 62
1915538 1991
19
Urinary N-acetyl-beta-glucosaminidase and the selection of children for radiologic evaluation after urinary tract infection. 53 62
2371096 1990
20
[Study on urinary low molecular protein and enzyme in primary vesico-ureteral reflux patients]. 53 62
2193184 1990
21
Laparoscopic vs Open Extravesical Ureteral Reimplantation in Pediatric Population: A Single-Center Experience. 62
36127884 2022
22
Evaluation of screening with urine dipsticks and renal ultrasonography for 3-year-olds in Chiba City over 30 years. 62
36056980 2022
23
Importance of urodynamic evaluation of bladder function after secondary untethering in spina bifida patients: single center experience of 30 years. 62
36454325 2022
24
Urological Impact of Epididymo-orchitis in Patients with Anorectal Malformation: An ARM-Net Consortium Study. 62
35073590 2022
25
Multi-institutional Validation of Improved Vesicoureteral Reflux Assessment With Simple and Machine Learning Approaches. 62
36215077 2022
26
Use of electronic health record best practice alerts to improve adherence to American Urological Association vesicoureteral reflux guidelines. 62
36454296 2022
27
Contrast-enhanced voiding urosonography (CEVUS) as a safe alternate means of assessing vesicoureteral reflux in pediatric kidney transplant patients. 62
36345140 2022
28
Diagnostic Imaging for Pediatric Vesicoureteral Reflux. 62
36344205 2022
29
Laparoscopic triple-ureteral ureteroureterostomy in a patient with ureteral triplication: A case report. 62
36343058 2022
30
Renal Cyst after Heminephrectomy in a Pediatric Patient: Complication or Normality? 62
36472064 2022
31
Duplex renal collecting system presenting with hydroureteronephrosis following pelvic organ prolapse and sacrocolpopexy in an adult female. 62
36033162 2022
32
Comparative study of open, laparoscopic and endoscopic treatments of intermediate grade vesicoureteral reflux in children. 62
36414870 2022
33
Diagnosis and treatment of neurogenic bladder secondary to aortic dissection: A 8-year retrospective study at a single center. 62
36000463 2022
34
Intravesical Botulinum toxin-A injection in pediatric overactive neurogenic bladder with Detrusor overactivity: Radiologic and clinical outcomes. 62
36404763 2022
35
Is technetium-99m dimercaptosuccinic acid renal scintigraphy available for predicting vesicoureteral reflux in children with first febrile urinary tract infection under the age of 24 months? 62
36164706 2022
36
An innovative diagnostic procedure in children: videourodynamics with contrast-enhanced voiding urosonography. 62
36417175 2022
37
The accuracy of cystography under general anesthesia in children with vesicoureteral reflux. 62
36423246 2022
38
A case of laparoscopic adhesiotomy for urodynia caused by bladder wall adhesion to the anterior abdominal wall after vesicoscopic ureteral reimplantation for vesicoureteral reflux. 62
36160066 2022
39
Prevalence of intrarenal reflux in pediatric patients on contrast-enhanced voiding urosonography. 62
36447052 2022
40
A comprehensive review on hydrogel materials in urology: Problems, methods, and new opportunities. 62
36237176 2022
41
Robotic ureteral reimplantation and uretero-ureterostomy treating the ureterovesical junction pathologies in children: technical considerations and preliminary results. 62
36287349 2022
42
Role of Contrast-Enhanced Voiding Urosonography in the Evaluation of Renal Transplant Reflux - Comparison with Voiding Cystourethrography and a New Classification. 62
33434942 2022
43
Imaging for Vesicoureteral Reflux: Point-Contrast-Enhanced Voiding Urosonography Is a Sensitive and Radiation-Free Imaging Method That Improves Patient Comfort. 62
35611919 2022
44
Response to Re: Vesicoureteral reflux treatment following kidney transplantation potentially prevents graft function deterioration and allows long-term graft survival. 62
36000802 2022
45
Imaging for Vesicoureteral Reflux: Counterpoint-Cost, Diagnostic Performance, and Preferences Need to Be Further Assessed Before Replacing VCUG With ceVUS. 62
35611923 2022
46
Re: Vesicoureteral reflux treatment following kidney transplantation potentially prevents graft function deterioration and allows long-term graft survival. 62
35844179 2022
47
Circumcision reduces urinary tract infection in children with antenatal hydronephrosis: Systematic review and meta-analysis. 62
36371332 2022
48
[Effect of topical glucocorticoid in treating phimosis on urinary tract infection of vesicoureteral reflux in infants]. 62
36229201 2022
49
Continence management in children with severe caudal regression syndrome: role of multidisciplinary team and long-term follow-up. 62
35943565 2022
50
Congenital malformations of the urinary tract: progression to chronic renal disease. 62
36217787 2022

Variations for Vesicoureteral Reflux

ClinVar genetic disease variations for Vesicoureteral Reflux:

5 (show all 15)
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 EBF3 NM_001375380.1(EBF3):c.280_283del (p.Glu94fs) DEL Pathogenic
375502 rs1057519521 GRCh37: 10:131761639-131761642
GRCh38: 10:129963375-129963378
2 MED13L NM_015335.5(MED13L):c.1971del (p.Asp657fs) DEL Pathogenic
523512 rs1555247805 GRCh37: 12:116446247-116446247
GRCh38: 12:116008442-116008442
3 C12orf57 NM_138425.4(C12orf57):c.53-2A>G SNV Pathogenic
242885 rs1114167293 GRCh37: 12:7053637-7053637
GRCh38: 12:6944474-6944474
4 NIPBL NM_133433.4(NIPBL):c.1052C>T (p.Pro351Leu) SNV Likely Pathogenic
978555 rs1743394245 GRCh37: 5:36976061-36976061
GRCh38: 5:36975959-36975959
5 KAT6B NM_012330.4(KAT6B):c.3399_3402del (p.Arg1133fs) DEL Likely Pathogenic
523499 rs1554844486 GRCh37: 10:76784742-76784745
GRCh38: 10:75024984-75024987
6 AFAP1L2, VWA2 NM_001272046.2(VWA2):c.1336C>T (p.Arg446Cys) SNV Likely Pathogenic
684663 rs148731211 GRCh37: 10:116046036-116046036
GRCh38: 10:114286277-114286277
7 ROBO2 NM_001395656.1(ROBO2):c.*2355T>A SNV Uncertain Significance
346749 rs766386654 GRCh37: 3:77697561-77697561
GRCh38: 3:77648410-77648410
8 ROBO2 NM_001395656.1(ROBO2):c.1984G>A (p.Val662Ile) SNV Uncertain Significance
346694 rs372550683 GRCh37: 3:77623650-77623650
GRCh38: 3:77574499-77574499
9 ROBO2 NM_001395656.1(ROBO2):c.*2570C>A SNV Uncertain Significance
346751 rs886058890 GRCh37: 3:77697776-77697776
GRCh38: 3:77648625-77648625
10 SOX17 NM_022454.4(SOX17):c.456G>C (p.Glu152Asp) SNV Likely Benign
523052 rs1554579184 GRCh37: 8:55371766-55371766
GRCh38: 8:54459206-54459206
11 ROBO2 NM_001395656.1(ROBO2):c.*3288del DEL Likely Benign
346765 rs566529890 GRCh37: 3:77698492-77698492
GRCh38: 3:77649341-77649341
12 ROBO2 NM_001395656.1(ROBO2):c.*3608dup DUP Likely Benign
346768 rs548297436 GRCh37: 3:77698807-77698808
GRCh38: 3:77649656-77649657
13 ROBO2 NM_001395656.1(ROBO2):c.*1619dup DUP Likely Benign
346738 rs530776423 GRCh37: 3:77696824-77696825
GRCh38: 3:77647673-77647674
14 ROBO2 NM_001395656.1(ROBO2):c.3566+13del DEL Benign
346707 rs78824327 GRCh37: 3:77666937-77666937
GRCh38: 3:77617786-77617786
15 ROBO2 NM_001128929.3(ROBO2):c.*3923C>T SNV Benign
369424 rs10865561 GRCh37: 3:77699129-77699129
GRCh38: 3:77649978-77649978

Expression for Vesicoureteral Reflux

Search GEO for disease gene expression data for Vesicoureteral Reflux.

Pathways for Vesicoureteral Reflux

GO Terms for Vesicoureteral Reflux

Biological processes related to Vesicoureteral Reflux according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 kidney development GO:0001822 10.04 UPK3A UMOD AGTR1 AGT
2 regulation of blood pressure GO:0008217 10.03 UMOD AGTR2 AGT
3 positive regulation of CoA-transferase activity GO:1905920 9.85 AGTR1 AGT
4 angiotensin-activated signaling pathway GO:0038166 9.84 AGTR2 AGTR1
5 positive regulation of NAD(P)H oxidase activity GO:0033864 9.83 AGTR1 AGT
6 regulation of renal sodium excretion GO:0035813 9.78 AGT AGTR1
7 negative regulation of neurotrophin TRK receptor signaling pathway GO:0051387 9.76 AGT AGTR2
8 metanephric distal convoluted tubule development GO:0072221 9.73 PAX2 UMOD
9 blood vessel diameter maintenance GO:0097746 9.71 AGTR2 AGTR1 AGT
10 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.69 AGTR1 AGT
11 positive regulation of metanephric glomerulus development GO:0072300 9.67 PAX2 AGTR2
12 maintenance of blood vessel diameter homeostasis by renin-angiotensin GO:0002034 9.62 AGTR1 AGT
13 renin-angiotensin regulation of aldosterone production GO:0002018 9.56 AGTR1 AGT
14 regulation of metanephros size GO:0035566 9.46 PAX2 AGTR2
15 G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger GO:0007199 9.26 AGTR2 AGT
16 positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 9.1 PAX2 AGTR2 AGT

Molecular functions related to Vesicoureteral Reflux according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 angiotensin type II receptor activity GO:0004945 8.92 AGTR2 AGTR1

Sources for Vesicoureteral Reflux

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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