MCID: VSC012
MIFTS: 32

Vesiculobullous Skin Disease

Categories: Skin diseases

Aliases & Classifications for Vesiculobullous Skin Disease

MalaCards integrated aliases for Vesiculobullous Skin Disease:

Name: Vesiculobullous Skin Disease 12 15
Skin Diseases, Vesiculobullous 44 73

Classifications:



External Ids:

Disease Ontology 12 DOID:2731
MeSH 44 D012872
UMLS 73 C0037275

Summaries for Vesiculobullous Skin Disease

MalaCards based summary : Vesiculobullous Skin Disease, also known as skin diseases, vesiculobullous, is related to skin disease and epidermolysis bullosa simplex with pyloric atresia, and has symptoms including pruritus and exanthema. An important gene associated with Vesiculobullous Skin Disease is COL7A1 (Collagen Type VII Alpha 1 Chain), and among its related pathways/superpathways are Integrin Pathway and Phospholipase-C Pathway. Affiliated tissues include skin and tonsil, and related phenotypes are craniofacial and digestive/alimentary

Related Diseases for Vesiculobullous Skin Disease

Diseases related to Vesiculobullous Skin Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Related Disease Score Top Affiliating Genes
1 skin disease 27.9 COL17A1 COL7A1 DST EXPH5 ITGA6 ITGB4
2 epidermolysis bullosa simplex with pyloric atresia 10.2 ITGB4 PLEC
3 epithelial basement membrane dystrophy 10.2 COL17A1 PLEC
4 benign breast adenomyoepithelioma 10.2 KRT14 KRT5
5 breast adenomyoepithelioma 10.2 KRT14 KRT5
6 epidermolysis bullosa simplex, autosomal recessive 1 10.2 KRT14 KRT5
7 pemphigoid gestationis 10.2 COL17A1 DST
8 large cell acanthoma 10.2 KRT14 KRT5
9 apocrine sweat gland neoplasm 10.2 KRT14 KRT5
10 breast squamous cell carcinoma 10.2 KRT14 KRT5
11 herpes gestationis 10.2 COL17A1 DST
12 cervical clear cell adenocarcinoma 10.2 KRT14 KRT5
13 odontoma 10.2 KRT14 KRT5
14 breast myoepithelial neoplasm 10.1 KRT14 KRT5
15 breast benign neoplasm 10.1 KRT14 KRT5
16 thoracic benign neoplasm 10.1 KRT14 KRT5
17 lipoadenoma 10.1 KRT14 KRT5
18 epidermolysis bullosa simplex, dowling-meara type 10.1 KRT14 KRT5
19 lipid-rich carcinoma 10.1 KRT14 KRT5
20 pregnancy adenoma 10.1 KRT14 KRT5
21 sweat gland disease 10.1 KRT14 KRT5
22 epidermolysis bullosa dystrophica 10.1 COL7A1 DST
23 lichen disease 10.1 COL17A1 DST
24 white sponge nevus 1 10.1 KRT14 PLEC
25 intraneural perineurioma 10.1 KRT14 KRT5
26 tonsil cancer 10.1 KRT14 KRT5
27 pre-malignant neoplasm 10.1 KRT14 KRT5
28 neurotic excoriation 10.1 COL17A1 COL7A1 DST
29 ecthyma 10.1 COL17A1 DST
30 lichen planopilaris 10.1 COL17A1 KRT14 KRT5
31 epidermolysis bullosa simplex with muscular dystrophy 10.1 COL17A1 DST PLEC
32 oropharynx cancer 10.1 KRT14 KRT5
33 kindler syndrome 10.0 COL7A1 DST ITGB4
34 lichen planus pemphigoides 10.0 COL17A1 DST ITGB4
35 epidermolysis bullosa simplex, localized 10.0 ITGB4 KRT14 KRT5
36 linear iga disease 10.0 COL17A1 DST ITGB4
37 in situ carcinoma 10.0 ITGB4 KRT14 KRT5
38 spindle cell carcinoma 10.0 KRT14 KRT5
39 aplasia cutis congenita 10.0 COL7A1 ITGA6 ITGB4
40 epidermolysis bullosa with pyloric atresia 10.0 ITGA6 ITGB4 PLEC
41 epidermolysis bullosa simplex with mottled pigmentation 10.0 EXPH5 KRT14 KRT5
42 ocular cicatricial pemphigoid 10.0 ITGA6 ITGB4
43 subcorneal pustular dermatosis 10.0 COL17A1 DST
44 epidermolysis bullosa simplex, generalized 9.9 KLHL24 KRT14 KRT5
45 maternal uniparental disomy of chromosome 1 9.9 LAMA3 LAMB3 LAMC2
46 epidermolysis bullosa, junctional, herlitz type 9.9 LAMA3 LAMB3 LAMC2
47 paraneoplastic pemphigus 9.9 COL17A1 DST
48 bullous skin disease 9.9 COL17A1 DST LAMA3
49 cellulitis 9.9 COL17A1 DST LAMA3
50 pyloric atresia 9.8 COL17A1 ITGA6 ITGB4 LAMC2 PLEC

Graphical network of the top 20 diseases related to Vesiculobullous Skin Disease:



Diseases related to Vesiculobullous Skin Disease

Symptoms & Phenotypes for Vesiculobullous Skin Disease

UMLS symptoms related to Vesiculobullous Skin Disease:


pruritus, exanthema

MGI Mouse Phenotypes related to Vesiculobullous Skin Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.97 COL7A1 ITGA6 ITGB4 KRT14 KRT5 LAMA3
2 digestive/alimentary MP:0005381 9.92 COL7A1 ITGA6 ITGB4 KRT14 KRT5 LAMA3
3 growth/size/body region MP:0005378 9.91 COL7A1 ITGA6 ITGB4 KRT14 KRT5 LAMA3
4 integument MP:0010771 9.81 COL7A1 ITGA6 ITGB4 KRT14 KRT5 LAMA3
5 mortality/aging MP:0010768 9.61 COL7A1 ITGA6 ITGB4 KRT14 KRT5 LAMA3
6 respiratory system MP:0005388 9.1 ITGA6 ITGB4 KRT14 LAMA3 LAMB3 LAMC2

Drugs & Therapeutics for Vesiculobullous Skin Disease

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Induction of Suction Blisters in Patients With Urticaria, Blistering Diseases, Inflammatory Dermatoses and Neoplastic Disorders, and in Normal Volunteers Completed NCT00001150

Search NIH Clinical Center for Vesiculobullous Skin Disease

Cochrane evidence based reviews: skin diseases, vesiculobullous

Genetic Tests for Vesiculobullous Skin Disease

Anatomical Context for Vesiculobullous Skin Disease

MalaCards organs/tissues related to Vesiculobullous Skin Disease:

41
Skin, Tonsil

Publications for Vesiculobullous Skin Disease

Articles related to Vesiculobullous Skin Disease:

# Title Authors Year
1
Vesiculobullous skin disease with prominent immunologic feature. ( 3312674 )
1987

Variations for Vesiculobullous Skin Disease

Expression for Vesiculobullous Skin Disease

Search GEO for disease gene expression data for Vesiculobullous Skin Disease.

Pathways for Vesiculobullous Skin Disease

Pathways related to Vesiculobullous Skin Disease according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.21 COL17A1 COL7A1 ITGA6 ITGB4 LAMA3 LAMB3
2
Show member pathways
12.87 COL17A1 COL7A1 ITGA6 ITGB4 LAMA3 LAMB3
3
Show member pathways
12.82 ITGA6 ITGB4 LAMA3 LAMB3 LAMC2
4
Show member pathways
12.73 ITGA6 ITGB4 LAMA3 LAMB3 LAMC2
5
Show member pathways
12.64 ITGA6 ITGB4 LAMA3 LAMB3 LAMC2
6 12.63 ITGA6 LAMA3 LAMB3 LAMC2
7
Show member pathways
12.38 COL17A1 DST ITGA6 ITGB4 LAMA3 LAMB3
8
Show member pathways
12.33 COL17A1 COL7A1 DST ITGA6 ITGB4 LAMA3
9
Show member pathways
12.2 ITGA6 ITGB4 LAMA3 LAMB3 LAMC2
10
Show member pathways
12.11 ITGA6 LAMA3 LAMB3 LAMC2
11
Show member pathways
12.02 COL17A1 COL7A1 ITGA6 ITGB4 LAMA3 LAMB3
12
Show member pathways
11.98 ITGA6 ITGB4 LAMA3 LAMB3 LAMC2
13
Show member pathways
11.93 ITGA6 ITGB4 LAMA3
14
Show member pathways
11.93 COL17A1 COL7A1 DST ITGA6 ITGB4 LAMA3
15 11.86 ITGA6 ITGB4 PLEC
16
Show member pathways
11.83 DST KRT14 KRT5 PLEC
17 11.75 ITGA6 LAMA3 LAMB3 LAMC2
18 11.73 LAMA3 LAMB3 LAMC2
19 11.52 LAMA3 LAMB3 LAMC2
20
Show member pathways
11.48 ITGA6 ITGB4 LAMA3 LAMB3 LAMC2
21 11.22 ITGA6 ITGB4
22 11.18 COL17A1 ITGA6 ITGB4
23 11.15 ITGB4 LAMA3
25 10.77 COL17A1 COL7A1 ITGA6 ITGB4 LAMA3 LAMB3

GO Terms for Vesiculobullous Skin Disease

Cellular components related to Vesiculobullous Skin Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell junction GO:0030054 9.8 COL17A1 DST ITGB4 KLHL24 PLEC
2 focal adhesion GO:0005925 9.73 DST ITGA6 ITGB4 PLEC
3 collagen-containing extracellular matrix GO:0062023 9.62 COL17A1 COL7A1 LAMA3 LAMC2
4 intermediate filament GO:0005882 9.56 DST KRT14 KRT5 PLEC
5 basement membrane GO:0005604 9.5 COL17A1 COL7A1 DST ITGA6 LAMA3 LAMB3
6 basal plasma membrane GO:0009925 9.48 DST ITGA6
7 integrin complex GO:0008305 9.46 ITGA6 ITGB4
8 basal part of cell GO:0045178 9.37 ITGA6 KRT14
9 laminin-5 complex GO:0005610 9.16 LAMA3 LAMB3
10 hemidesmosome GO:0030056 9.02 COL17A1 DST ITGA6 ITGB4 PLEC

Biological processes related to Vesiculobullous Skin Disease according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.8 COL7A1 DST ITGA6 ITGB4 LAMA3 LAMB3
2 extracellular matrix organization GO:0030198 9.7 COL17A1 COL7A1 ITGA6 ITGB4 LAMA3 LAMB3
3 cell-matrix adhesion GO:0007160 9.63 COL17A1 ITGA6 ITGB4
4 integrin-mediated signaling pathway GO:0007229 9.61 DST ITGA6 ITGB4
5 digestive tract development GO:0048565 9.54 ITGA6 ITGB4
6 brown fat cell differentiation GO:0050873 9.52 ITGA6 LAMB3
7 cell motility GO:0048870 9.51 DST ITGB4
8 endodermal cell differentiation GO:0035987 9.5 COL7A1 LAMA3 LAMB3
9 epidermis development GO:0008544 9.5 COL17A1 COL7A1 KRT14 KRT5 LAMA3 LAMB3
10 intermediate filament cytoskeleton organization GO:0045104 9.49 DST PLEC
11 renal system development GO:0072001 9.48 ITGA6 ITGB4
12 amelogenesis GO:0097186 9.4 ITGA6 ITGB4
13 nail development GO:0035878 9.37 ITGA6 ITGB4
14 hemidesmosome assembly GO:0031581 9.32 COL17A1 DST ITGA6 ITGB4 KRT14 KRT5

Molecular functions related to Vesiculobullous Skin Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent GO:0005201 9.5 COL17A1 LAMA3 LAMC2
2 structural constituent of cytoskeleton GO:0005200 9.43 KRT14 KRT5 PLEC
3 extracellular matrix structural constituent conferring tensile strength GO:0030020 9.37 COL17A1 COL7A1
4 structural molecule activity GO:0005198 9.26 DST LAMA3 LAMB3 PLEC
5 insulin-like growth factor I binding GO:0031994 9.16 ITGA6 ITGB4
6 neuregulin binding GO:0038132 8.62 ITGA6 ITGB4

Sources for Vesiculobullous Skin Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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