Aliases & Classifications for Vestibular Disease

MalaCards integrated aliases for Vestibular Disease:

Name: Vestibular Disease 12 15
Vestibular Diseases 44 73
Vertigo, Vestibular Disorder 12
Vestibular Dysfunction 29
Diseases of Inner Ear 73
Vestibular Disorder 55

Classifications:



External Ids:

Disease Ontology 12 DOID:3426
ICD10 33 H81 H81.9 H81.90
MeSH 44 D015837
UMLS 73 C0042594

Summaries for Vestibular Disease

MalaCards based summary : Vestibular Disease, also known as vestibular diseases, is related to deafness, autosomal dominant 9 and meniere disease, and has symptoms including vertigo and vertigo/dizziness. An important gene associated with Vestibular Disease is COCH (Cochlin), and among its related pathways/superpathways are Gap junction trafficking and Vasopressin-regulated water reabsorption. The drugs Phenol and Glycerol have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and liver, and related phenotypes are hearing/vestibular/ear and homeostasis/metabolism

Related Diseases for Vestibular Disease

Diseases related to Vestibular Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 98)
# Related Disease Score Top Affiliating Genes
1 deafness, autosomal dominant 9 32.5 COCH FAM136A
2 meniere disease 31.6 AQP2 COCH FAM136A
3 motion sickness 29.9 AVP FAM136A
4 sensorineural hearing loss 28.8 COCH GJB2 GJB3 GJB6 SLC26A4
5 deafness, autosomal recessive 84a 11.7
6 usher syndrome, type i 11.3
7 usher syndrome, type iiia 11.1
8 usher syndrome, type iiib 11.0
9 sinoatrial node dysfunction and deafness 11.0
10 usher syndrome, type ic 10.9
11 albinism, ocular, with late-onset sensorineural deafness 10.9
12 usher syndrome, type id 10.9
13 usher syndrome, type if 10.9
14 usher syndrome, type ig 10.9
15 usher syndrome, type ih 10.9
16 deafness, autosomal recessive 25 10.9
17 deafness, autosomal recessive 79 10.9
18 usher syndrome, type ij 10.9
19 deafness, autosomal recessive 18b 10.9
20 usher syndrome, type ik 10.9
21 deafness, autosomal dominant 36 10.7 GJB2 SLC26A4
22 hypotrichosis-deafness syndrome 10.7 GJB2 GJB3
23 deafness, autosomal recessive 93 10.7 GJB2 GJB3
24 deafness, autosomal recessive 28 10.7 GJB2 GJB3
25 deafness, autosomal recessive 26 10.6 GJB2 SLC26A4
26 mental retardation, enteropathy, deafness, peripheral neuropathy, ichthyosis, and keratoderma 10.6 GJB2 GJB3
27 deafness, autosomal recessive 30 10.6 GJB2 SLC26A4
28 deafness, autosomal dominant 6 10.6 COCH GJB2 SLC26A4
29 deafness, autosomal dominant 13 10.5 COCH GJB2 SLC26A4
30 autosomal recessive nonsyndromic deafness 3 10.5 GJB2 SLC26A4
31 non-syndromic genetic deafness 10.4 COCH GJB2
32 deafness, autosomal recessive 67 10.4 GJB2 GJB3
33 inappropriate adh syndrome 10.4 AQP2 AVP
34 deafness, autosomal dominant 24 10.4 GJB2 GJB6
35 congenital cytomegalovirus 10.3 GJB2 GJB6
36 knuckle pads, leukonychia, and sensorineural deafness 10.3 GJB2 GJB6
37 deafness, x-linked 2 10.3 GJB2 GJB6
38 dfnb1 10.3 GJB2 GJB6
39 impaired renal function disease 10.3 AQP2 AVP
40 vohwinkel syndrome 10.3 GJB2 GJB6
41 syndrome of inappropriate antidiuretic hormone 10.3 AQP2 AVP
42 autosomal recessive nonsyndromic deafness 10.2 GJB2 SLC26A4
43 diabetes insipidus, neurohypophyseal 10.2 AQP2 AVP
44 obstructive hydrocephalus 10.2 CRLF1 GJB6
45 plexopathy 10.2 AVP CRLF1
46 deafness, autosomal dominant 2a 10.1 COCH GJB2 GJB6
47 deafness, autosomal recessive 23 10.1 GJB2 GJB6 SLC26A4
48 ear malformation 10.1 FOXI1 GJB2 KCNJ10 SLC26A4
49 autosomal dominant nonsyndromic deafness 10.0 COCH FAM136A GJB2 GJB3
50 brain compression 10.0 AVP GJB6

Graphical network of the top 20 diseases related to Vestibular Disease:



Diseases related to Vestibular Disease

Symptoms & Phenotypes for Vestibular Disease

UMLS symptoms related to Vestibular Disease:


vertigo, vertigo/dizziness

MGI Mouse Phenotypes related to Vestibular Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hearing/vestibular/ear MP:0005377 9.7 KCNJ10 SLC26A4 COCH FOXI1 GJB2 GJB6
2 homeostasis/metabolism MP:0005376 9.7 AQP2 AVP DIO3 FOXI1 GJB2 GJB3
3 nervous system MP:0003631 9.28 AVP CRLF1 FOXI1 GJB2 GJB6 KCNE3

Drugs & Therapeutics for Vestibular Disease

Drugs for Vestibular Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 147)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Phenol Approved, Experimental Phase 4 108-95-2 996
2
Glycerol Approved, Investigational Phase 4 56-81-5 753
3
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
4
Thymol Approved Phase 4 89-83-8 6989
5 Piracetam Approved, Investigational Phase 4 7491-74-9
6
Calcium Carbonate Approved, Investigational Phase 4 471-34-1
7
Metoclopramide Approved, Investigational Phase 4 364-62-5 4168
8
Histamine Approved, Investigational Phase 4,Phase 3,Not Applicable 75614-87-8, 51-45-6 774
9
Dimenhydrinate Approved Phase 4,Phase 3 523-87-5 441281
10
Betahistine Approved, Investigational Phase 4,Not Applicable 5638-76-6 2366
11
Ethanol Approved Phase 4 64-17-5 702
12
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
13
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
14
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
15
Glucosamine Approved, Investigational, Nutraceutical Phase 4 3416-24-8 439213
16
Nicotinamide Approved, Investigational, Nutraceutical Phase 4 98-92-0 936
17
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
18
Niacin Approved, Investigational, Nutraceutical Phase 4 59-67-6 938
19
Tocopherol Approved, Investigational, Nutraceutical Phase 4 1406-66-2 14986
20
Caffeine Approved, Nutraceutical Phase 4 58-08-2 2519
21
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 6221 5280795
22
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
23
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
24
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
25 Fibrinolytic Agents Phase 4
26 Glucuronyl glucosamine glycan sulfate Phase 4
27 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
28 Hypoglycemic Agents Phase 4
29 Hypolipidemic Agents Phase 4
30 Anticoagulants Phase 4
31 Lipid Regulating Agents Phase 4
32 Antimetabolites Phase 4
33
Histamine Phosphate Phase 4,Phase 3,Not Applicable 51-74-1 65513
34 glucocorticoids Phase 4,Phase 2
35 Micronutrients Phase 4
36 Central Nervous System Stimulants Phase 4
37 Gastrointestinal Agents Phase 4,Phase 3,Not Applicable
38 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
39 Histamine Antagonists Phase 4,Phase 3,Not Applicable
40 Histamine H1 Antagonists Phase 4,Phase 3,Not Applicable
41 Tocopherols Phase 4
42 Tocotrienols Phase 4
43 Nicotinic Acids Phase 4
44 Hormone Antagonists Phase 4,Phase 2
45 Trace Elements Phase 4
46 Hormones Phase 4,Phase 2
47 Antacids Phase 4
48 Dopamine Agents Phase 4
49 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2
50 Dopamine Antagonists Phase 4

Interventional clinical trials:

(show top 50) (show all 144)
# Name Status NCT ID Phase Drugs
1 Effects on the Diagnostic Accuracy of Magnetic Imaging Angiographies of the Supra-Aortic Vessels by Three Different Magnetic Resonance Contrast Agents in Patients Unknown status NCT00132223 Phase 4 Contrast agent
2 Effects of Betaserc on Vestibular Compensation in Patients Suffering From Disabling Meniere's Disease and Having Undergone Vestibular Neurotomy Completed NCT00160238 Phase 4 Betahistine 24 mg bid (Betaserc)
3 Effect of Caffeine Intake in Vestibular Function Completed NCT02825199 Phase 4
4 Comparison of Efficacy Between Piracetam and Dimenhydrinate in Patients With Peripheral Vertigo Completed NCT01890538 Phase 4 Administration of 100 mg dimenhydrinate intravenous;2 g piracetam intravenous
5 Comparison of Efficacy Dimenhydrinate and Metoclopramide in the Treatment of Nausea Due to Vertigo Completed NCT02253524 Phase 4 Dimenhydrinate;Metoclopramide
6 Efficacy of Vitamin D and Calcium Supplementation on the Prevention of Recurrences in BPPV Completed NCT02031692 Phase 4 400IU cholecalciferol and 500mg of elemental calcium as calcium carbonate
7 Effect of Stellate Ganglion Block on Meniere's Disease Completed NCT01574313 Phase 4 0.25mg, fludiazine;25mg cephadol@ (diphenidol);200mg kentons@ (tocopherol nicotinate).
8 Chlorobutanol, Potassium Carbonate, and Irrigation in Cerumen Removal Completed NCT00765635 Phase 4 drops intilation (Taponoto ® );drops intilation (Otocerum®);drops intilation (Placebo)
9 Acute Unilateral Vestibulopathy and Corticosteroid Treatment Recruiting NCT02912182 Phase 4 Betamethasone;Placebo;Prednisolone
10 A Study To Evaluate The Efficacy And Safety Of Betahistine Mesilate In The Treatment Of Patients With Vertigo Caused By Cerebral Infarction In Posterior Circulation Withdrawn NCT00474409 Phase 4 Merislon
11 Efficacy of Antiviral Medications in Controlling Vertigo Attacks of Patients With Meniere's Disease Unknown status NCT01729767 Phase 2, Phase 3 Acyclovir;Placebo
12 Conventional Versus Virtual Reality Based Vestibular Rehabilitation Completed NCT01442623 Phase 2, Phase 3
13 Study of Lamotrigine to Treat Ménière's Disease Completed NCT02158585 Phase 3 Lamotrigine;Placebo
14 The Treatment of Posterior Semicircular Canal Benign Paroxysmal Positional Vertigo Completed NCT02029508 Phase 3
15 Promethazine vs. Lorazepam for Treatment of Vertigo Completed NCT01827293 Phase 3 Promethazine;Lorazepam
16 Treatment of Geotropic Horizontal Canal Benign Paroxysmal Positional Vertigo Completed NCT01366430 Phase 3
17 Treatment of Apogeotropic Horizontal Canal Benign Paroxysmal Positional Vertigo Completed NCT00810641 Phase 3
18 Canalith Repositioning Procedure for BPPV in Primary Care Completed NCT00182273 Phase 3
19 Effects of Prismatic Spectacle Lenses on Symptoms of Dizziness, Headache and Anxiety as Caused by Vertical Heterophoria Completed NCT00785135 Phase 3
20 Non Inferiority of Meclin® (Meclizine Chlorhydrate) Versus Dramin® (Dimenhydrinate) in Control of Acute Vertigo Symptoms From Peripheral Origin Recruiting NCT02112578 Phase 3 Meclizine;Dimenhydrinate
21 Rizatriptan for Episodic Dizziness in Vestibular Migraine Recruiting NCT02447991 Phase 2, Phase 3 Rizatriptan;Placebo
22 Visual Feedback Goggle for Positional Vertigo Treatment Unknown status NCT00729885 Phase 1, Phase 2
23 Efficacy of Extended-release, Once Daily Tramadol for Post Operative Analgesia in Shoulder Arthroscopy Unknown status NCT02247648 Phase 2 tramadol;Placebo
24 Prednisone Treatment for Vestibular Neuronitis Completed NCT00271791 Phase 2 Prednisone;Prednisone
25 A Clinical Trial To Evaluate Efficacy And Safety Of Levophencynonate Hydrochloride In Patient With Vertigo Completed NCT02299804 Phase 2 Levophencynonate Hydrochloric;Placebo
26 Treatment of Apogeotropic Horizontal Canal Benign Paroxysmal Positional Vertigo Completed NCT02046980 Phase 2
27 Effect of V0251 in Acute Vertigo Completed NCT01583738 Phase 2 V0251;placebo
28 Treatments for Benign Paroxysmal Positional Vertigo (BPPV) Completed NCT00000359 Phase 2
29 A Trial of Booklet Based Self Management of Dizziness Completed NCT00732797 Phase 2
30 4-Aminopyridine, Atenolol, or Placebo in Patients With Vestibular Migraine Not yet recruiting NCT03578354 Phase 2 4-aminopyridine;Atenolol
31 Use of a Vibrotactile Sensory Prosthesis in Patients With Postural Imbalance and Spatial Disorientation Unknown status NCT00146952 Phase 1
32 Head-Mounted Vibrotactile Prosthesis for Patients With Chronic Postural Instability Completed NCT00889824 Phase 1
33 Verapamil vs. Sertraline for Vestibular Migraine & Chronic Subjective Dizziness Completed NCT01669304 Phase 1 Verapamil;Sertraline
34 Physiotherapy in Vestibular Disorders Unknown status NCT02746770 Not Applicable
35 Game Based Vestibular Exercise for Home Rehabilitation Unknown status NCT02134444 Not Applicable
36 Vestibular and Multisensory Influence on Bodily and Spatial Representations Unknown status NCT02072460 Not Applicable
37 Biological Rhythms and Vestibular System Unknown status NCT01839409 Not Applicable
38 Neural Mechanisms Engaged in Control of Eye Movements Unknown status NCT00999934
39 The Liberatory Maneuver for the Treatment of Benign Paroxysmal Positional Vertigo (BPPV) Unknown status NCT01008124 Not Applicable
40 Evaluation of the Sensorial Preference Unknown status NCT01146249
41 Proof of Concept Study Concerning Vestibular Stimulation Using a New Method of Dynamic Posturography. Unknown status NCT02851524 Not Applicable
42 Vestibular System in Migrainous Vertigo Patients Unknown status NCT00901953
43 Comorbidity Between Balance and Childhood Anxiety Unknown status NCT00599742 Not Applicable
44 Efficacy of Postural Restriction in Treating Benign Paroxysmal Positional Vertigo Unknown status NCT02475239 Not Applicable
45 Tailored Care for Somatoform Vertigo/Dizziness Unknown status NCT02320851 Not Applicable
46 Treatment of Posterior Canal Type of Benign Paroxysmal Positional Vertigo Unknown status NCT01822002 Not Applicable
47 The Head Impulse Test in the Screening of Vestibular Function Unknown status NCT01426932
48 Pilot Project on External Vestibular Prosthesis in Chronic Subjective Dizziness Unknown status NCT02048670 Not Applicable
49 Electrical Stimulation and Chemotherapy Induced Peripheral Neuropathy Unknown status NCT02088996 Not Applicable
50 Cervical Mobility and Vestibular Rehabilitation Completed NCT02622516 Not Applicable

Search NIH Clinical Center for Vestibular Disease

Cochrane evidence based reviews: vestibular diseases

Genetic Tests for Vestibular Disease

Genetic tests related to Vestibular Disease:

# Genetic test Affiliating Genes
1 Vestibular Dysfunction 29

Anatomical Context for Vestibular Disease

MalaCards organs/tissues related to Vestibular Disease:

41
Testes, Brain, Liver, Pons, Bone, Eye

Publications for Vestibular Disease

Articles related to Vestibular Disease:

(show top 50) (show all 58)
# Title Authors Year
1
Treating peripheral vestibular disease-associated nausea. ( 28432250 )
2017
2
An unusual case of peripheral vestibular disease in a cat following ear cleaning. ( 28216690 )
2017
3
Health care utilization, prognosis and outcomes of vestibular disease in primary care settings: systematic review. ( 27083883 )
2016
4
Congenital vestibular disease in captive Sumatran tigers (Panthera tigris ssp. sumatrae) in Australasia. ( 26403953 )
2015
5
Central vestibular disease in a blue and gold macaw (Ara ararauna) with cerebral infarction and hemorrhage. ( 25115042 )
2014
6
What is your neurologic diagnosis? Vestibular disease. ( 24871057 )
2014
7
Endoscopic findings of the external ear canal in a group of clinically normal horses and horses with head shaking or vestibular disease. ( 24693653 )
2014
8
Diagnostic imaging of peripheral vestibular disease in a Chinese goose (Anser cygnoides). ( 24881151 )
2014
9
Proposed treatment for geriatric vestibular disease in dogs. ( 25103883 )
2014
10
Influence of vestibular disease on psychological distress: a multicenter study. ( 23380760 )
2013
11
Vestibular disease: anatomy, physiology, and clinical signs. ( 22847320 )
2012
12
Vestibular disease: diseases causing vestibular signs. ( 22847321 )
2012
13
Modifications of muscle synergies and spinal maps due to absence of visual feedback in patients with unilateral vestibular disease. ( 23366708 )
2012
14
Diversity of head shaking nystagmus in peripheral vestibular disease. ( 22525213 )
2012
15
Selective atonal gene delivery improves balance function in a mouse model of vestibular disease. ( 21472006 )
2011
16
Patients' psychological well-being and resilient coping protect from secondary somatoform vertigo and dizziness (SVD) 1A year after vestibular disease. ( 20717689 )
2011
17
The reliability and response stability of dynamic testing of the vestibulo-ocular reflex in patients with vestibular disease. ( 22101298 )
2011
18
Vestibular disease in dogs and cats. ( 19942058 )
2010
19
Reliability, validity, and sensitivity to change of Turkish Activities-specific Balance Confidence Scale in patients with unilateral peripheral vestibular disease. ( 20183891 )
2010
20
Clinical romberg testing does not detect vestibular disease. ( 20502374 )
2010
21
Clinical signs, magnetic resonance imaging findings and outcome in 77 cats with vestibular disease: a retrospective study. ( 19932040 )
2010
22
Diabetic polyneuropathy may increase the handicap related to vestibular disease. ( 19427968 )
2009
23
Unilateral vestibular disease. ( 19412404 )
2009
24
What is your neurologic diagnosis? Vestibular disease secondary to brain neoplasm. ( 19284335 )
2009
25
Blood glucose and insulin levels in patients with peripheral vestibular disease. ( 19893939 )
2009
26
Depersonalisation/derealisation symptoms and updating orientation in patients with vestibular disease. ( 17578858 )
2008
27
The effect of vestibular rehabilitation supplemented by training of the breathing rhythm or proprioception exercises, in patients with chronic peripheral vestibular disease. ( 18219105 )
2007
28
Hypothyroid-associated central vestibular disease in 10 dogs: 1999-2005. ( 17186851 )
2006
29
Depersonalisation/derealisation symptoms in vestibular disease. ( 16464901 )
2006
30
Signs of neurologic dysfunction in dogs with central versus peripheral vestibular disease. ( 16117064 )
2005
31
Subjective assessment of visual verticality in follow-up of patients with acute vestibular disease. ( 12861870 )
2003
32
Vestibular disease and cognitive dysfunction: no evidence for a causal connection. ( 12973270 )
2003
33
Is hyperventilation-induced nystagmus more common in retrocochlear vestibular disease than in end-organ vestibular disease? ( 12121015 )
2002
34
Visual and psychological aspects of vestibular disease. ( 11796943 )
2002
35
Paradoxical vestibular disease with trigeminal nerve-sheath tumor in a dog. ( 11525099 )
2001
36
Peripheral vestibular disease associated with cryptococcosis in three cats. ( 11716589 )
2000
37
Psychiatric symptoms and distress differ between patients with postherpetic neuralgia and peripheral vestibular disease. ( 10750630 )
2000
38
Vestibular disease in two horses: a case of mycotic otitis media and a case of temporohyoid osteoarthropathy. ( 10466833 )
1999
39
In vitro release kinetics of gentamycin from a sodium hyaluronate gel delivery system suitable for the treatment of peripheral vestibular disease. ( 10028414 )
1999
40
Vestibular disease unmasked by hyperventilation. ( 9546279 )
1998
41
Evaluation of health-related quality of life in individuals with vestibular disease using disease-specific and general outcome measures. ( 9291947 )
1997
42
Evaluation and treatment of uncompensated unilateral vestibular disease. ( 9295251 )
1997
43
Surgical treatment of uncompensated vestibular disease. ( 9295252 )
1997
44
Use of magnetic resonance imaging in the diagnosis of central vestibular disease. ( 8993783 )
1997
45
Infrared/video ENG recording of positional nystagmus in subjects with peripheral vestibular disease. ( 8749181 )
1995
46
New posture equilibrometer for the diagnosis of vestibular disease. ( 2029391 )
1991
47
Congenital peripheral vestibular disease attributed to lymphocytic labyrinthitis in two related litters of Doberman pinscher pups. ( 2010340 )
1991
48
A posture equilibrometer for the diagnosis of vestibular disease. ( 2517087 )
1989
49
Visual symptoms of vestibular disease. ( 3263137 )
1988
50
Diagnosis of retrocochlear and central vestibular disease by magnetic resonance imaging. ( 3257674 )
1988

Variations for Vestibular Disease

Expression for Vestibular Disease

Search GEO for disease gene expression data for Vestibular Disease.

Pathways for Vestibular Disease

Pathways related to Vestibular Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.79 GJB2 GJB3 GJB6
2 10.6 AQP2 AVP

GO Terms for Vestibular Disease

Cellular components related to Vestibular Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 gap junction GO:0005921 9.13 GJB2 GJB3 GJB6
2 connexin complex GO:0005922 8.8 GJB2 GJB3 GJB6

Biological processes related to Vestibular Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 renal water homeostasis GO:0003091 9.26 AQP2 AVP
2 water transport GO:0006833 9.16 AQP2 AVP
3 cell communication GO:0007154 9.13 GJB2 GJB3 GJB6
4 sensory perception of sound GO:0007605 8.92 COCH GJB2 GJB6 SLC26A4

Molecular functions related to Vestibular Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 gap junction channel activity GO:0005243 8.62 GJB2 GJB3

Sources for Vestibular Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....