Aliases & Classifications for Vestibular Disease

MalaCards integrated aliases for Vestibular Disease:

Name: Vestibular Disease 12 15 17
Vestibular Diseases 43 71
Vertigo, Vestibular Disorder 12
Diseases of Inner Ear 71
Vestibular Disorder 54

Classifications:



External Ids:

Disease Ontology 12 DOID:3426
MeSH 43 D015837
SNOMED-CT 67 20425006
ICD10 32 H81 H81.9 H81.90
UMLS 71 C0042594 C0494559

Summaries for Vestibular Disease

MalaCards based summary : Vestibular Disease, also known as vestibular diseases, is related to meniere disease and vestibular neuronitis, and has symptoms including vertigo and vertigo/dizziness. An important gene associated with Vestibular Disease is COCH (Cochlin), and among its related pathways/superpathways is Gap junction trafficking. The drugs Caffeine and Methylprednisolone hemisuccinate have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and eye, and related phenotypes are behavior/neurological and hearing/vestibular/ear

Related Diseases for Vestibular Disease

Diseases related to Vestibular Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 266)
# Related Disease Score Top Affiliating Genes
1 meniere disease 32.5 FAM136A COCH AQP2
2 vestibular neuronitis 31.1 RTEL1 OTOL1
3 benign paroxysmal positional nystagmus 31.0 RTEL1 OTOL1
4 branchiootic syndrome 1 30.6 SLC26A4 OTOF MYO7A GJB2 CDH23
5 viral labyrinthitis 30.3 GJB6 GJB2
6 cogan syndrome 30.3 GJB2 COCH
7 congenital cytomegalovirus 30.2 MT-RNR1 GJB6 GJB2
8 superior semicircular canal dehiscence 30.2 RTEL1 CRLF1 COCH
9 deafness, autosomal dominant 28 30.1 FAM136A COCH
10 otosclerosis 30.1 SLC26A4 RTEL1 MT-RNR1 GJB6 GJB2 CRLF1
11 deafness, autosomal dominant 9 30.1 PCDH15 MYO7A GJB2 FAM136A COCH
12 ear malformation 30.1 SLC26A4 KCNJ10 GJB2 FOXI1
13 deafness, autosomal recessive 4, with enlarged vestibular aqueduct 30.0 SLC26A4 PCDH15 OTOF MYO7A MYO15A MT-RNR1
14 labyrinthitis 30.0 SLC26A4 MYO7A GJB6 GJB2 CRLF1 COCH
15 deafness, autosomal dominant 15 30.0 MYO7A FAM136A COCH
16 deafness, autosomal dominant 11 29.3 PCDH15 MYO7A MYO15A GJB2 COCH CDH23
17 inner ear disease 28.5 SLC26A4 RTEL1 MYO7A MT-RNR1 KCNJ10 GJB6
18 peripheral vertigo 28.5 SLC26A4 RTEL1 OTOL1 KCNE1 GJB2 FOXI1
19 nonsyndromic deafness 28.1 SLC26A4 PCDH15 OTOF MYO7A MYO15A MT-RNR1
20 sensorineural hearing loss 27.5 SLC26A4 PCDH15 OTOF MYO7A MYO15A MT-RNR1
21 auditory system disease 26.9 SLC26A4 RTEL1 PCDH15 OTOF MYO7A MYO15A
22 nonsyndromic hearing loss and deafness, dfna3 10.6 GJB6 GJB2
23 hypotrichosis-deafness syndrome 10.6 GJB3 GJB2
24 deafness, autosomal dominant 24 10.6 GJB6 GJB2
25 purulent labyrinthitis 10.5 GJB6 GJB2
26 deafness, x-linked 2 10.5 GJB6 GJB2
27 branchiootic syndrome 10.5 SLC26A4 GJB2 FOXI1
28 keratitis-ichthyosis-deafness syndrome, autosomal dominant 10.5 GJB6 GJB2
29 erythrokeratoderma 10.5 GJB3 GJB2
30 deafness, autosomal dominant 2a 10.5 GJB2 COCH
31 deafness, autosomal dominant 64 10.5 GJB6 GJB2
32 vestibulocochlear nerve disease 10.5 RTEL1 OTOL1
33 pendred syndrome/nonsyndromic enlarged vestibular aqueduct 10.5 SLC26A4 KCNJ10 FOXI1
34 deafness, autosomal dominant 56 10.5 SLC26A4 GJB2 COCH
35 hereditary distal renal tubular acidosis 10.5 FOXI1 ATP6V1B1
36 vohwinkel syndrome 10.5 GJB6 GJB2
37 deafness, autosomal dominant 2b 10.5 SLC26A4 GJB3 GJB2
38 deafness, autosomal dominant 59 10.5 GJB6 GJB2 FOXI1
39 nonsyndromic hearing loss and deafness, dfnb1 10.5 GJB6 GJB3 GJB2
40 renal tubular acidosis, distal, autosomal recessive 10.5 FOXI1 ATP6V1B1
41 deafness, autosomal recessive 59 10.5 OTOF GJB2
42 pseudoainhum 10.5 GJB6 GJB3 GJB2
43 deafness, autosomal recessive 77 10.5 SLC26A4 GJB2 CDH23
44 deafness, autosomal recessive 1b 10.4 GJB6 GJB3 GJB2
45 deafness, autosomal dominant 3b 10.4 GJB6 GJB3 GJB2
46 knuckle pads 10.4 GJB6 GJB3 GJB2
47 knuckle pads, leukonychia, and sensorineural deafness 10.4 GJB6 GJB3 GJB2
48 deafness, autosomal recessive 61 10.4 SLC26A4 OTOF
49 deafness, autosomal recessive 26 10.4 MT-RNR1 GJB2
50 clouston syndrome 10.4 GJB6 GJB3 GJB2

Graphical network of the top 20 diseases related to Vestibular Disease:



Diseases related to Vestibular Disease

Symptoms & Phenotypes for Vestibular Disease

UMLS symptoms related to Vestibular Disease:


vertigo, vertigo/dizziness

MGI Mouse Phenotypes related to Vestibular Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.93 AQP2 ATP6V1B1 CDH23 CRLF1 FOXI1 GJB6
2 hearing/vestibular/ear MP:0005377 9.77 ATP6V1B1 CDH23 COCH FOXI1 GJB2 GJB3
3 nervous system MP:0003631 9.44 ATP6V1B1 CDH23 CRLF1 FOXI1 GJB2 GJB6

Drugs & Therapeutics for Vestibular Disease

Drugs for Vestibular Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 69)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Caffeine Approved Phase 4 58-08-2 2519
2
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
3
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
4
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
5 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
6
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
7
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
8
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
9 Neurotransmitter Agents Phase 4
10 Central Nervous System Stimulants Phase 4
11 Phosphodiesterase Inhibitors Phase 4
12 Anti-Inflammatory Agents Phase 4
13 Autonomic Agents Phase 4
14 Gastrointestinal Agents Phase 4
15 Antiemetics Phase 4
16 Anti-Asthmatic Agents Phase 4
17 Respiratory System Agents Phase 4
18 Methylprednisolone Acetate Phase 4
19 Hormone Antagonists Phase 4
20 Betamethasone benzoate Phase 4
21 Betamethasone Valerate Phase 4 2152-44-5
22 Protective Agents Phase 4
23 Neuroprotective Agents Phase 4
24 Antineoplastic Agents, Hormonal Phase 4
25 Betamethasone sodium phosphate Phase 4
26 glucocorticoids Phase 4
27 Betamethasone-17,21-dipropionate Phase 4
28 Hormones Phase 4
29
Lamotrigine Approved, Investigational Phase 3 84057-84-1 3878
30
Calcium Approved, Nutraceutical Phase 3 7440-70-2 271
31 Antipsychotic Agents Phase 3
32 Tranquilizing Agents Phase 3
33 Anticonvulsants Phase 3
34 Psychotropic Drugs Phase 3
35 Sodium Channel Blockers Phase 3
36 Calcium, Dietary Phase 3
37 Central Nervous System Depressants Phase 3
38 calcium channel blockers Phase 3
39 Diuretics, Potassium Sparing Phase 3
40
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
41
Propranolol Approved, Investigational 525-66-6 4946
42
Lorazepam Approved 846-49-1 3958
43
Ondansetron Approved 99614-02-5 4595
44
Meclizine Approved 569-65-3 4034
45
Diazepam Approved, Illicit, Investigational, Vet_approved 439-14-5 3016
46
Diphenhydramine Approved, Investigational 147-24-0, 58-73-1 3100
47
Promethazine Approved, Investigational 60-87-7 4927
48
Histamine Approved, Investigational 51-45-6 774
49
Betahistine Approved, Investigational 5638-76-6 2366
50 Anesthetics

Interventional clinical trials:

(show top 50) (show all 95)
# Name Status NCT ID Phase Drugs
1 Effect of Caffeine Intake in Vestibular Function: A Randomized Triple-Blind Controlled Trial Completed NCT02825199 Phase 4
2 Acute Unilateral Vestibulopathy and Corticosteroid Treatment Suspended NCT02912182 Phase 4 Betamethasone;Placebo;Prednisolone
3 Conventional Versus Virtual Reality Based Vestibular Rehabilitation; Effect on Dizziness, Gait and Balance Completed NCT01442623 Phase 2, Phase 3
4 Lamotrigine for Ménière's Disease: a Double-blind, Placebo-controlled Pilot Study Completed NCT02158585 Phase 3 Lamotrigine;Placebo
5 Visual Feedback Goggle For The Treatment Of Benign Paroxysmal Positional Vertigo in a Randomized Single-Blind Study Unknown status NCT00729885 Phase 1, Phase 2
6 Prednisone Treatment for Vestibular Neuronitis Completed NCT00271791 Phase 2 Prednisone;Prednisone
7 Prospective, Randomized, Placebo-controlled, Phase 2 Study of 4-aminopyridine, Atenolol, or Placebo in the Treatment of Patients With Vestibular Migraine Withdrawn NCT03578354 Phase 2 4-aminopyridine;Atenolol
8 Evaluation of a Vibrotactile Sensory Aid Developed by the US Navy to Combat Pilot Disorientation as a Prosthesis in Patients With Postural Imbalance and Spatial Disorientation Unknown status NCT00146952 Phase 1
9 Physiotherapy in Vestibular Disorders Unknown status NCT02746770
10 The Effect of OMT on Functional Outcomes and Anti-inflammatory Biomarkers in Mild to Moderate Traumatic Brain Injury Unknown status NCT03163901
11 Biological Rhythms and Vestibular System Unknown status NCT01839409
12 Vestibular and Multisensory Influence on Bodily and Spatial Representations. Behavioral and Electrophysiological Investigations in Vestibular-defective Patients and Healthy Volunteers Unknown status NCT02072460
13 Clinical Utility of Simultaneous Recordings of Cervical and Ocular Vestibular-evoked Myogenic Potentials During Monaural Stimulation Unknown status NCT03049683
14 The Liberatory Maneuver for the Treatment of Benign Paroxysmal Positional Vertigo: A Randomized Controlled Trial Unknown status NCT01008124
15 Comorbidity Between Balance and Childhood Anxiety: Treatment of Anxiety by Training of Balance Unknown status NCT00599742
16 Endothelial Dysfunction in Hyperemesis Gravidarum Unknown status NCT02989337
17 Neural Mechanisms Engaged in Control of Eye Movements Unknown status NCT00999934
18 Comparison of Clinical and Game-based Rehabilitation for Balance Impairments and Gaze Dysfunction in Clients With Vestibular Disorders Unknown status NCT02134444
19 Evaluation of the Sensorial Preference for Balance Control Unknown status NCT01146249
20 The Assessment and Treatment of Balance Impairment Using Virtual Reality (VR) in Panic Disorder Patients Unknown status NCT01677429
21 Cawthorne Cooksey Versus Vestibular Habituation Exercises on Trunk Kinetics and Velocity of Gait in Patients With Multiple Sclerosis Completed NCT03670459
22 Study of Rotatory Vestibular Tests in Major Depression Patients and Healthy Control Subjects. Completed NCT03421847
23 Efficacy Of Biofeedback Training And Whole Body Vibration Therapy In Vestibular Rehabilitation Of Unilateral Vestibular Weakness Completed NCT03973255
24 Evaluation Of Vestibular Functions and Balance in Edirne Band Musicians Completed NCT03915353
25 Effects of a Virtual Reality-based Dual-task Exercise on Vestibular Function in Healthy Community Dwellers. A Pilot Study Completed NCT03160352
26 The Effects of Vibrotactile Feedback During Vestibular Rehabilitation Completed NCT02867683
27 Head-Mounted Vibrotactile Prosthesis for Patients With Chronic Postural Instability Completed NCT03330262
28 Impact Des déficits Vestibulaires Sur le développement Des Fonctions Visuo-spatiales. Completed NCT02533739
29 Diagnostic Accuracy of the Vibration Induced Nystagmus Test in Room Light. Completed NCT02626052
30 Vestibular Rehabilitation and Dizziness in Geriatric Patients Completed NCT01729039
31 Clinical Randomized Trial to Evaluate the Efficacy of Vestibular Stimulation as Coadjuvant Therapy in Major Depression Completed NCT01399671
32 Gaze and Movement Behavior of Patients With Vestibular Dysfunction During Level Floor, Ramp, and Stair Walking Completed NCT02417545
33 Assessment of Visual Sensitivity, Psychiatric Profile and Quality of Life Following Vestibular Schwannoma Surgery in Patients Prehabituated by Chemical Vestibular Ablation Completed NCT03638310
34 Pilot Study of Vestibular Rehabilitation Training for Panic Disorder With Vestibular Dysfunction Completed NCT00004366
35 Effects of Vestibular Rehabilitation in the Treatment of Patients With Acute Vestibular Loss. - A Randomized Controlled Trial Completed NCT00702832
36 Effectiveness of Additional Protocol Exercises for Cervical Mobility and Proprioception in Vestibular Rehabilitation: a Randomized Controlled Trial Completed NCT02622516
37 Quality of Life and Dynamic Visual Acuity in Patients With Bilateral Vestibulopathy: the Impact of Covert-saccades Completed NCT02753179
38 Unilateral Peripheral Vestibular Dysfunction: Reeducation and Spatial Orientation. Completed NCT03171181
39 Efficacy of Vestibular Rehabilitation in Patients With Vestibular Migraine Completed NCT03417596
40 Functional Link Between Hippocampal and Vestibular Systems: a Pilot Study in Epilepsy Surgery Principal Investigator: Elizabeth VITTE Completed NCT01285921
41 A Randomized, Double Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of SpotOn Specs™ for the Treatment of Chronic Dizziness Completed NCT01460121
42 Effects of a Virtual Reality-based Dual-task Exercise on Vestibular Function in Patients With Chronic Peripheral Unilateral Vestibular Hypofunction Completed NCT03536533
43 A Controlled Clinical Study to Evaluate the Safety and Efficacy of the BrainPort® Balance Device When Used to Improve Balance in Subjects With Peripheral Vestibular Dysfunction Completed NCT00768378
44 Study on the Mnemic Functioning of Children With Kabuki Syndrome Completed NCT03547609
45 Vestibular and Multisensory Influence on Bodily and Spatial Representations. Behavioral and Electrophysiological Investigations in Vestibular-defective Patients and Healthy Volunteers Completed NCT01900457
46 the Effect of Vestibular Rehabilitation on Sensory Profile and Postrotary Nistagmus in Austistic Children Completed NCT03957044
47 Vestibular Rehabilitation for Patients With Fall-related Wrist Fractures - a Randomized Controlled Trial Completed NCT00988572
48 The Effects of Local Vibration and Cervical Stabilization Exercises Applied on Neck Muscles on Balance in Healthy Individuals Completed NCT03464214
49 Home-based Computer Gaming in Vestibular Rehabilitation: Effects on Gaze and Balance Impairment Completed NCT01943955
50 Clinical Trial Evaluation of a Sensory Enrichment Multimodal Device (SEMD) on Physical Therapy Patients With Disequilibrium Completed NCT01483937

Search NIH Clinical Center for Vestibular Disease

Cochrane evidence based reviews: vestibular diseases

Genetic Tests for Vestibular Disease

Anatomical Context for Vestibular Disease

MalaCards organs/tissues related to Vestibular Disease:

40
Testes, Brain, Eye, T Cells, Endothelial, Pons, Bone

Publications for Vestibular Disease

Articles related to Vestibular Disease:

(show top 50) (show all 388)
# Title Authors PMID Year
1
Otitis Media in Childhood and Disease in Adulthood: A 40-Year Follow-Up Study. 61
30998545 2020
2
Clinical and radiological characteristics of patients with collapse or fistula of the saccule as evaluated by inner ear MRI. 61
31961235 2020
3
Vestibular disease in dogs: association between neurological examination, MRI lesion localisation and outcome. 61
31515806 2020
4
Economic burden of vertigo: a systematic review. 61
31883042 2019
5
Otology/Neurotology recommendations - Choosing Wisely campaign. 61
31703748 2019
6
Recovery of ocular and cervical vestibular evoked myogenic potentials after treatment of inner ear diseases. 61
31070081 2019
7
Risk of traffic accidents after onset of vestibular disease assessed with a surrogate marker. 61
30963255 2019
8
[Prevalence of peripheral vestibular diseases in children in Germany]. 61
31506769 2019
9
Hearing as an Independent Predictor of Postural Balance in 1075 Patients Evaluated for Dizziness. 61
31013210 2019
10
Association Between Saccule and Semicircular Canal Impairments and Cognitive Performance Among Vestibular Patients. 61
31567562 2019
11
Comparative study of anti-vertiginous and anti-anxious drugs for the treatment of chronic vestibular patients with secondary anxiety. 61
31107129 2019
12
A decade of magnetic vestibular stimulation: from serendipity to physics to the clinic. 61
30969883 2019
13
[Relationship between the level of estrogen, calcium and phosphorus concentration in serum with benign paroxysmal positional vertigo]. 61
31163520 2019
14
Histamine H4 receptor gene polymorphisms: a potential contributor to Meniere disease. 61
31133025 2019
15
[The subjective perception of the vertical-a valuable parameter for determination of peripheral vestibular disorder in Menière's disease in the chronic phase?] 61
30725124 2019
16
[Recognizing non-structural vestibular diseases]. 61
30813681 2019
17
Video Head Impulse Test to Preoperatively Identify the Nerve of Origin of Vestibular Schwannomas. 61
29750273 2019
18
Clinical features and short-term outcome of presumptive intracranial complications associated with otitis media/interna: a multi-center retrospective study of 19 cats (2009-2017). 61
29667535 2019
19
Novel Use of Portable Audiometry to Track Hearing Fluctuations in Menière's Disease: A Pilot Study. 61
30614898 2019
20
Inner ear drug delivery: Recent advances, challenges, and perspective. 61
29792920 2019
21
Safety, tolerability, pharmacokinetics and pharmacokinetic-pharmacodynamic modelling of the novel H4 receptor inhibitor SENS-111 using a modified caloric test in healthy subjects. 61
30152527 2018
22
Multicenter data banking in management of dizzy patients: first results from the DizzyNet registry project. 61
29663119 2018
23
Genetic contribution to vestibular diseases. 61
29582143 2018
24
Tone-induced cervical and ocular vestibular-evoked myogenic potentials: comparing abnormalities in traumatic and non-traumatic vestibular disease. 61
30295212 2018
25
Evaluation of Benign Paroxysmal Positional Vertigo in American Football Players. 61
30256203 2018
26
An attempt to measure the diametric relationship between slow and quick phases of nystagmus. 61
29355067 2018
27
[Advances in peripheral vestibular diseases with downbeat nystagmus]. 61
29986573 2018
28
Prevalence and management of post-BPPV residual symptoms. 61
29687182 2018
29
[Etiological characteristics analysis of 3 137 outpatients with vertigo or dizziness in ENT department]. 61
29873213 2018
30
Bilateral tympanokeratomas (cholesteatomas) with bilateral otitis media, unilateral otitis interna and acoustic neuritis in a dog. 61
29788991 2018
31
The Dizziness Handicap Inventory does not correlate with vestibular function tests: a prospective study. 61
29557501 2018
32
Reliability of interpretation of neurologic examination findings for the localization of vestibular dysfunction in dogs. 61
29553894 2018
33
Deafness and vestibular dysfunction in a Doberman Pinscher puppy associated with a mutation in the PTPRQ gene. 61
29460419 2018
34
μVEMP: A Portable Interface to Record Vestibular Evoked Myogenic Potentials (VEMPs) With a Smart Phone or Tablet. 61
30026727 2018
35
Diagnosis of Vertigo and Dizziness Syndromes in a Neurological Outpatient Clinic. 61
29794430 2018
36
Inpatient Treatment of Patients Admitted for Dizziness: A Population-Based Healthcare Research Study on Epidemiology, Diagnosis, Treatment, and Outcome. 61
28938275 2017
37
Survey of systemic antimicrobial prescribing for dogs by Victorian veterinarians. 61
28948625 2017
38
Motion-based equilibrium reprocessing therapy a novel treatment method for chronic peripheral vestibulopathies: A pilot study. 61
28614234 2017
39
The TriAGe+ Score for Vertigo or Dizziness: A Diagnostic Model for Stroke in the Emergency Department. 61
28256416 2017
40
Treating peripheral vestibular disease-associated nausea. 61
28432250 2017
41
Video head impulse test: a review of the literature. 61
27328962 2017
42
[The significance of directional preponderance in the evaluation of vestibular function in patients with vertigo]. 61
28395491 2017
43
An unusual case of peripheral vestibular disease in a cat following ear cleaning. 61
28216690 2017
44
Recent surgical options for vestibular vertigo. 61
29279721 2017
45
Guided and unguided internet-based vestibular rehabilitation versus usual care for dizzy adults of 50 years and older: a protocol for a three-armed randomised trial. 61
28110290 2017
46
Aging with Cerebral Small Vessel Disease and Dizziness: The Importance of Undiagnosed Peripheral Vestibular Disorders. 61
28626444 2017
47
Is Alteration of Tuning Property in Cervical Vestibular-Evoked Myogenic Potential Specific for Ménière's Disease? 61
28533763 2017
48
Computed tomography and magnetic resonance imaging findings for the initial stage of equine temporohyoid osteoarthropathy in a Thoroughbred foal. 61
28955164 2017
49
[The ultrastructure of utricular maculae of mouse]. 61
28104018 2017
50
Vibration-Induced Nystagmus: A Biomarker for Vestibular Deficits - A Synopsis. 61
28231579 2017

Variations for Vestibular Disease

Expression for Vestibular Disease

Search GEO for disease gene expression data for Vestibular Disease.

Pathways for Vestibular Disease

Pathways related to Vestibular Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.79 GJB6 GJB3 GJB2

GO Terms for Vestibular Disease

Cellular components related to Vestibular Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 basolateral plasma membrane GO:0016323 9.62 OTOF KCNJ10 ATP6V1B1 AQP2
2 gap junction GO:0005921 9.43 GJB6 GJB3 GJB2
3 apical plasma membrane GO:0016324 9.43 SLC26A4 MYO7A KCNE1 GJB6 ATP6V1B1 AQP2
4 connexin complex GO:0005922 9.33 GJB6 GJB3 GJB2
5 stereocilium GO:0032420 8.92 PCDH15 MYO7A MYO15A CDH23

Biological processes related to Vestibular Disease according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 transmembrane transport GO:0055085 9.97 SLC26A4 GJB6 GJB3 GJB2 AQP2
2 visual perception GO:0007601 9.81 PCDH15 MYO7A KCNJ10 CDH23
3 locomotory behavior GO:0007626 9.71 PCDH15 MYO15A CDH23
4 inner ear morphogenesis GO:0042472 9.62 MYO7A MYO15A FOXI1 ATP6V1B1
5 cell communication GO:0007154 9.58 GJB6 GJB3 GJB2
6 regulation of pH GO:0006885 9.56 SLC26A4 ATP6V1B1
7 potassium ion homeostasis GO:0055075 9.55 KCNJ10 ATP6V1B1
8 inner ear receptor cell stereocilium organization GO:0060122 9.54 PCDH15 MYO7A CDH23
9 auditory receptor cell stereocilium organization GO:0060088 9.52 PCDH15 MYO7A
10 gap junction assembly GO:0016264 9.49 GJB6 GJB2
11 inner ear auditory receptor cell differentiation GO:0042491 9.48 PCDH15 MYO7A
12 cell communication by electrical coupling GO:0010644 9.46 GJB6 GJB2
13 inner ear development GO:0048839 9.46 PCDH15 MYO7A GJB6 GJB2
14 gap junction-mediated intercellular transport GO:1990349 9.43 GJB6 GJB2
15 sensory perception of light stimulus GO:0050953 9.43 PCDH15 MYO7A CDH23
16 sensory perception of sound GO:0007605 9.36 SLC26A4 PCDH15 OTOF MYO7A MYO15A KCNE1
17 equilibrioception GO:0050957 9.13 PCDH15 MYO7A CDH23

Molecular functions related to Vestibular Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 gap junction channel activity involved in cell communication by electrical coupling GO:1903763 8.96 GJB6 GJB2
2 gap junction channel activity GO:0005243 8.8 GJB6 GJB3 GJB2

Sources for Vestibular Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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