MCID: VST001
MIFTS: 35

Vestibular Neuronitis

Categories: Ear diseases, Neuronal diseases

Aliases & Classifications for Vestibular Neuronitis

Summaries for Vestibular Neuronitis

Disease Ontology : 12 A inner ear infectious disease caused by a viral infection which involves inflammation of the vestibular nerve. It usually results as a complication of an upper respiratory infection. This causes sudden and severe vertigo, nausea and vomiting. Auditory symptoms are usually absent.

MalaCards based summary : Vestibular Neuronitis, also known as epidemic neurolabyrinthitis, is related to viral labyrinthitis and labyrinthitis. An important gene associated with Vestibular Neuronitis is RTEL1 (Regulator Of Telomere Elongation Helicase 1). The drugs Methylprednisolone and Prednisolone phosphate have been mentioned in the context of this disorder. Affiliated tissues include eye and testes, and related phenotypes are Synthetic lethal with vaccinia virus (VACV) infection and embryo

Wikipedia : 77 Labyrinthitis, also known as vestibular neuritis, is the inflammation of the inner ear. It results in a... more...

Related Diseases for Vestibular Neuronitis

Graphical network of the top 20 diseases related to Vestibular Neuronitis:



Diseases related to Vestibular Neuronitis

Symptoms & Phenotypes for Vestibular Neuronitis

GenomeRNAi Phenotypes related to Vestibular Neuronitis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with vaccinia virus (VACV) infection GR00362-A 8.8 CACNA1A PIR SALL1

MGI Mouse Phenotypes related to Vestibular Neuronitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 8.92 LMX1A PIR RTEL1 SALL1

Drugs & Therapeutics for Vestibular Neuronitis

Drugs for Vestibular Neuronitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Not Applicable 83-43-2 6741
2
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Not Applicable 302-25-0
3
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Not Applicable 2921-57-5
4
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Not Applicable 50-24-8 5755
5
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
6
Prednisolone hemisuccinate Experimental Phase 4,Phase 3,Not Applicable 2920-86-7
7 Neuroprotective Agents Phase 4,Phase 3,Not Applicable
8 glucocorticoids Phase 4,Phase 3,Phase 2,Not Applicable
9 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Not Applicable
10 Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
11 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Not Applicable
12 Antiemetics Phase 4,Phase 3,Not Applicable
13 Gastrointestinal Agents Phase 4,Phase 3,Not Applicable
14 Prednisolone acetate Phase 4,Phase 3,Not Applicable
15 Autonomic Agents Phase 4,Phase 3,Not Applicable
16 Hormones Phase 4,Phase 3,Phase 2,Not Applicable
17 Protective Agents Phase 4,Phase 3,Not Applicable
18 Methylprednisolone Acetate Phase 4,Phase 3,Not Applicable
19 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
20 Peripheral Nervous System Agents Phase 4,Phase 3,Not Applicable
21 Betamethasone Valerate Phase 4 2152-44-5
22 Betamethasone-17,21-dipropionate Phase 4
23 Anti-Asthmatic Agents Phase 4,Phase 3
24 Betamethasone sodium phosphate Phase 4
25 Respiratory System Agents Phase 4,Phase 3
26 Betamethasone benzoate Phase 4
27
Cilostazol Approved, Investigational Phase 3 73963-72-1 2754
28 Ginkgo Phase 3
29 Phosphodiesterase Inhibitors Phase 3
30 Bronchodilator Agents Phase 3
31 Fibrinolytic Agents Phase 3
32 Phosphodiesterase 3 Inhibitors Phase 3
33 Vasodilator Agents Phase 3
34 Platelet Aggregation Inhibitors Phase 3
35
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
36
Dexamethasone Approved, Investigational, Vet_approved Early Phase 1 50-02-2 5743
37
Dexamethasone acetate Approved, Investigational, Vet_approved Early Phase 1 1177-87-3
38 BB 1101 Early Phase 1

Interventional clinical trials:

(show all 21)
# Name Status NCT ID Phase Drugs
1 Acute Unilateral Vestibulopathy and Corticosteroid Treatment Recruiting NCT02912182 Phase 4 Betamethasone;Placebo;Prednisolone
2 The Efficacy of Steroid Therapy in Vestibular Neuritis Completed NCT02098330 Phase 3 Ginkgo biloba & Methylprednisolone;Ginkgo biloba
3 Effect of Renexin Tablet in Patients With Recurrent Vestibulopathy Terminated NCT01895400 Phase 3 Renexin (cilostazol 100mg + gingko biloba extract 80 mg);Placebo
4 Prednisone Treatment for Vestibular Neuronitis Completed NCT00271791 Phase 2 Prednisone;Prednisone
5 Complementary/Alternative Medicine for Abnormality in the Vestibular (Balance) System Completed NCT00032383 Phase 1, Phase 2
6 Incremental Velocity Error as a New Treatment in Vestibular Rehabilitation Not yet recruiting NCT03846830 Phase 2
7 The Role of Corticosteroids and Vestibular Exercises in Recovery of Vestibular Neuritis Unknown status NCT01231009 Early Phase 1 Corticosteroids
8 Characterisation of Cortical Vestibular Evoked Potentials (C-VEPs) Unknown status NCT02463695 Not Applicable
9 Simultaneous Recordings of Cervical and Ocular Vestibular-evoked Myogenic Potentials Unknown status NCT03049683
10 Vestibular System in Migrainous Vertigo Patients Unknown status NCT00901953
11 Game Based Vestibular Exercise for Home Rehabilitation Unknown status NCT02134444 Not Applicable
12 Recovery of Visual Acuity in People With Vestibular Deficits Completed NCT00411216 Not Applicable
13 Home-based Computer Gaming in Vestibular Rehabilitation Completed NCT01943955 Not Applicable
14 Clinical Evaluation of a Novel Balance, Vestibular and Oculomotor Assessment Tool Completed NCT02171312
15 Spatial Orientation and Vestibular Function Completed NCT02212847 Not Applicable
16 To Study the Characteristics of Different Types of Vertigo in Patients Attending the Ear Nose & Throat (ENT) Clinics. Completed NCT02213120
17 MRIPositive Diagnosis of Vestibular Neuritis Using Fluid Attenuated Inversion Recuperation (FLAIR) Sequence on a 1.5 Tesla Recruiting NCT03452410
18 Does Vestibular Rehabilitation Significantly Improve the Level of Vestibular Function Following Vestibular Neuritis? Recruiting NCT03821155 Not Applicable Corticosteroid
19 Assessment and Treatment of Patients With Long-term Dizziness in Primary Care Recruiting NCT02655575 Not Applicable
20 Acute Video-oculography for Vertigo in Emergency Rooms for Rapid Triage (AVERT) Recruiting NCT02483429 Not Applicable
21 Vestibulopathy With Vestibulo Ocular Reflex (VOR) Gain Deficit Not yet recruiting NCT03271775 Not Applicable

Search NIH Clinical Center for Vestibular Neuronitis

Cochrane evidence based reviews: vestibular neuronitis

Genetic Tests for Vestibular Neuronitis

Anatomical Context for Vestibular Neuronitis

MalaCards organs/tissues related to Vestibular Neuronitis:

42
Eye, Testes

Publications for Vestibular Neuronitis

Articles related to Vestibular Neuronitis:

(show top 50) (show all 76)
# Title Authors Year
1
Steroids for Acute Vestibular Neuronitis-the Earlier the Treatment, the Better the Outcome? ( 30681432 )
2019
2
Bell's palsy and vestibular neuronitis. ( 25015516 )
2014
3
Investigation of seasonal variability of vestibular neuronitis. ( 24063368 )
2013
4
Herpes simplex virus type 1 in saliva of patients with vestibular neuronitis: a preliminary study. ( 22045284 )
2011
5
Comorbid intracranial vertebral artery asymmetry as a risk factor for severe vestibular neuronitis. ( 21317672 )
2011
6
Treatment of acute vestibular neuronitis with glucocorticoids. ( 21817947 )
2011
7
Vestibular evoked myogenic potentials in vestibular neuronitis. ( 22368986 )
2011
8
Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Bet 1: steroids for patients with vestibular neuronitis. ( 19850811 )
2009
9
[Late and sudden recovery of sudden deafness or vestibular neuronitis]. ( 17692812 )
2007
10
Herpes encephalitis preceded by ipsilateral vestibular neuronitis. ( 16246566 )
2005
11
A prospective study on the course of anxiety after vestibular neuronitis. ( 15046973 )
2004
12
Vestibular neuronitis in pilots: follow-up results and implications for flight safety. ( 12567089 )
2003
13
Lipoprotein (a) and acute-phase response in patients with vestibular neuronitis. ( 14636287 )
2003
14
Vestibular neuronitis: a viral neuropathy. ( 12077899 )
2002
15
Vestibular neuronitis in children: study of medium and long term follow-up. ( 10967381 )
2000
16
Vestibular neuronitis. ( 10431900 )
1999
17
The pathology of facial and vestibular neuronitis. ( 10442771 )
1999
18
A proposal for introducing a modified vestibular index in neurotology. The classification of vestibular neuronitis. ( 8891479 )
1996
19
Comparative study on gait abnormality in patients with vestibular neuronitis and patients with large acoustic neuroma. ( 7610866 )
1995
20
Central disorders in vestibular neuronitis. ( 7610868 )
1995
21
Enhanced MRI in patients with vestibular neuronitis. ( 7610885 )
1995
22
A case with symptoms of vestibular neuronitis caused by an intramedullary lesion. ( 7642999 )
1995
23
Vestibular neuronitis: a review of a common cause of vertigo in general practice. ( 8323804 )
1993
24
Vestibular compensation in vestibular neuronitis. Long-term follow-up evaluation. ( 8379299 )
1993
25
Bilateral vestibular neuronitis. ( 8470502 )
1993
26
A clinical observation of benign paroxysmal positional vertigo (BPPV) after vestibular neuronitis (VN). ( 8470503 )
1993
27
Neuroborreliosis in the etiology of vestibular neuronitis. ( 8470505 )
1993
28
Vestibular neuronitis: epidemiological survey by questionnaire in Japan. ( 8470507 )
1993
29
Serum viral antibody titer in vestibular neuronitis. ( 8385868 )
1993
30
Vestibular neuronitis. Proceedings of an international symposium on vestibular ganglia and vestibular neuronitis. Yamaguchi, Japan, 14-16 September, 1991. ( 8470473 )
1993
31
Clinical observation of 32 cases of vestibular neuronitis. ( 8470478 )
1993
32
Progress of caloric response of vestibular neuronitis. ( 8470487 )
1993
33
Vestibular neuronitis evaluated by the combined galvanic test. ( 8470489 )
1993
34
Interpretation of the combined galvanic test. Findings from cases with vestibular neuronitis. ( 8470490 )
1993
35
Relationship between GBST and equilibrium examination in vestibular neuronitis. ( 8470491 )
1993
36
Vestibular compensation in vestibular neuronitis: evaluation of positional nystagmus and caloric nystagmus. ( 8470494 )
1993
37
Recovery of the vestibular function after vestibular neuronitis. ( 8470496 )
1993
38
Follow-up of square drawing test in vestibular neuronitis. ( 8470497 )
1993
39
Prolonged dysequilibrium in three cases with vestibular neuronitis: efficacy of vestibular rehabilitation. ( 8470498 )
1993
40
Vestibular neuronitis in children. ( 8470500 )
1993
41
Vestibular neuronitis in aged patients: results from an epidemiological survey by questionnaire in Japan. ( 8470501 )
1993
42
A clinical study of vestibular neuronitis. ( 1897712 )
1991
43
Compensatory process of vestibular neuronitis. From findings of combined galvanic test and caloric test. ( 1927436 )
1991
44
Vestibular neuronitis. Pathogenesis in the view of virological study of CSF. ( 2635536 )
1989
45
Serovirological study of vestibular neuronitis. ( 2635537 )
1989
46
Vestibular neuronitis. An otoneurological evaluation. ( 3068952 )
1988
47
Vestibular neuronitis in childhood. ( 3245418 )
1988
48
Vestibular neuronitis--serum and CSF virus antibody titer. ( 3017280 )
1986
49
Neurotologic evidence of central and peripheral involvement in patients with vestibular neuronitis. ( 3931027 )
1985
50
Vestibular neuronitis: neurotological findings and progress. ( 4022591 )
1985

Variations for Vestibular Neuronitis

Expression for Vestibular Neuronitis

Search GEO for disease gene expression data for Vestibular Neuronitis.

Pathways for Vestibular Neuronitis

GO Terms for Vestibular Neuronitis

Biological processes related to Vestibular Neuronitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 central nervous system neuron differentiation GO:0021953 8.62 CACNA1A LMX1A

Molecular functions related to Vestibular Neuronitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metal ion binding GO:0046872 9.02 CACNA1A LMX1A PIR RTEL1 SALL1

Sources for Vestibular Neuronitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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