MCID: VST001
MIFTS: 37

Vestibular Neuronitis

Categories: Ear diseases, Neuronal diseases

Aliases & Classifications for Vestibular Neuronitis

MalaCards integrated aliases for Vestibular Neuronitis:

Name: Vestibular Neuronitis 12 44 15 17 72 33
Epidemic Neurolabyrinthitis 12
Vestibular Neuritis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12683
ICD9CM 35 078.81 386.12
MeSH 44 D020338
SNOMED-CT 68 34243007 43680000
UMLS 72 C0751908

Summaries for Vestibular Neuronitis

Disease Ontology : 12 A inner ear infectious disease caused by a viral infection which involves inflammation of the vestibular nerve. It usually results as a complication of an upper respiratory infection. This causes sudden and severe vertigo, nausea and vomiting. Auditory symptoms are usually absent.

MalaCards based summary : Vestibular Neuronitis, also known as epidemic neurolabyrinthitis, is related to labyrinthitis and viral labyrinthitis. An important gene associated with Vestibular Neuronitis is ASPRV1 (Aspartic Peptidase Retroviral Like 1). The drugs Prednisolone phosphate and Methylprednisolone hemisuccinate have been mentioned in the context of this disorder. Affiliated tissues include testes, eye and bone, and related phenotypes are embryo and integument

Wikipedia : 75 Labyrinthitis, also known as vestibular neuritis, is the inflammation of the inner ear. It results in a... more...

Related Diseases for Vestibular Neuronitis

Diseases related to Vestibular Neuronitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 69)
# Related Disease Score Top Affiliating Genes
1 labyrinthitis 11.7
2 viral labyrinthitis 11.7
3 neuronitis 10.8
4 pathologic nystagmus 10.5
5 migraine with or without aura 1 10.2
6 pica disease 10.0
7 panic disorder 10.0
8 branchiootic syndrome 1 10.0
9 benign paroxysmal positional nystagmus 10.0
10 vestibular nystagmus 10.0
11 neuritis 10.0
12 herpes simplex 10.0
13 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.9
14 carotid artery occlusion 9.9
15 herpes zoster 9.9
16 chickenpox 9.9
17 rubella 9.9
18 peripheral vertigo 9.9
19 myoclonus and ataxia 9.9
20 rheumatoid arthritis 9.9
21 strabismus 9.9
22 vitiligo-associated multiple autoimmune disease susceptibility 6 9.9
23 homocysteinemia 9.9
24 orthostatic intolerance 9.9
25 vitiligo-associated multiple autoimmune disease susceptibility 1 9.9
26 leukemia, acute lymphoblastic 3 9.9
27 cogan syndrome 9.9
28 viral meningitis 9.9
29 depersonalization disorder 9.9
30 somatization disorder 9.9
31 central nervous system origin vertigo 9.9
32 parasitic protozoa infectious disease 9.9
33 vestibular disease 9.9
34 somatoform disorder 9.9
35 mechanical strabismus 9.9
36 meningitis 9.9
37 aneurysm 9.9
38 meniere disease 9.8
39 motion sickness 9.8
40 otitis media 9.8
41 ataxia and polyneuropathy, adult-onset 9.8
42 anxiety 9.8
43 postural orthostatic tachycardia syndrome 9.8
44 sensorineural hearing loss 9.8
45 mumps 9.8
46 brucellosis 9.8
47 vertebral artery occlusion 9.8
48 tetanus 9.8
49 lyme disease 9.8
50 otosclerosis 9.8

Graphical network of the top 20 diseases related to Vestibular Neuronitis:



Diseases related to Vestibular Neuronitis

Symptoms & Phenotypes for Vestibular Neuronitis

MGI Mouse Phenotypes related to Vestibular Neuronitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.26 KMT2A LMX1A PIR RTEL1
2 integument MP:0010771 8.92 ASPRV1 CACNA1A KMT2A LMX1A

Drugs & Therapeutics for Vestibular Neuronitis

Drugs for Vestibular Neuronitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 39)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
2
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
3
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
4
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
5
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
6
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
7 Anti-Inflammatory Agents Phase 4
8 Gastrointestinal Agents Phase 4
9 Antiemetics Phase 4
10 glucocorticoids Phase 4
11 Hormones Phase 4
12 Methylprednisolone Acetate Phase 4
13 Antineoplastic Agents, Hormonal Phase 4
14 Hormone Antagonists Phase 4
15 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
16 Prednisolone acetate Phase 4
17 Betamethasone Valerate Phase 4 2152-44-5
18 Betamethasone sodium phosphate Phase 4
19 Betamethasone-17,21-dipropionate Phase 4
20 Betamethasone benzoate Phase 4
21
Cilostazol Approved, Investigational Phase 3 73963-72-1 2754
22 Neuroprotective Agents Phase 3
23 Peripheral Nervous System Agents Phase 3
24 Protective Agents Phase 3
25 Autonomic Agents Phase 3
26 Ginkgo Phase 3
27 Respiratory System Agents Phase 3
28 Anti-Asthmatic Agents Phase 3
29 Fibrinolytic Agents Phase 3
30 Phosphodiesterase Inhibitors Phase 3
31 Platelet Aggregation Inhibitors Phase 3
32 Vasodilator Agents Phase 3
33 Bronchodilator Agents Phase 3
34 Phosphodiesterase 3 Inhibitors Phase 3
35
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
36
Dexamethasone Approved, Investigational, Vet_approved Early Phase 1 50-02-2 5743
37
Dexamethasone acetate Approved, Investigational, Vet_approved Early Phase 1 1177-87-3
38 Kava Approved, Investigational, Nutraceutical 9000-38-8
39 BB 1101 Early Phase 1

Interventional clinical trials:

(show all 22)
# Name Status NCT ID Phase Drugs
1 Acute Unilateral Vestibulopathy and Corticosteroid Treatment Suspended NCT02912182 Phase 4 Betamethasone;Placebo;Prednisolone
2 The Efficacy of Steroid Therapy in Vestibular Neuritis Confirmed by Head Impulse Test: Prospective Randomized Controlled Study Completed NCT02098330 Phase 3 Ginkgo biloba & Methylprednisolone;Ginkgo biloba
3 A Single-center, Prospective, Randomized, Parallel Group, Placebo-controlled Exploratory Study on the Effect of Renexin Tablet in Patients With Recurrent Vestibulopathy Terminated NCT01895400 Phase 3 Renexin (cilostazol 100mg + gingko biloba extract 80 mg);Placebo
4 Prednisone Treatment for Vestibular Neuronitis Completed NCT00271791 Phase 2 Prednisone;Prednisone
5 Complementary/Alternative Medicine for Vestibulopathy Completed NCT00032383 Phase 1, Phase 2
6 INVENT VPT: Incremental Velocity Error as a New Treatment in Vestibular Rehabilitation Not yet recruiting NCT03846830 Phase 2
7 The Role of Corticosteroids and Vestibular Exercises in Recovery of Vestibular Neuritis: a Prospective Randomized Controlled Clinical Trial Unknown status NCT01231009 Early Phase 1 Corticosteroids
8 Do Migrainous Vertigo Patients Have More Hypersensitivity in Their Vestibular System Than Migraine Patients Without Vertigo? Unknown status NCT00901953
9 Clinical Utility of Simultaneous Recordings of Cervical and Ocular Vestibular-evoked Myogenic Potentials During Monaural Stimulation Unknown status NCT03049683
10 Characterisation of Cortical Vestibular Evoked Potentials (C-VEPs): A Comparative Study of Normal Ears Versus Those With Vestibular Deficits Unknown status NCT02463695
11 Comparison of Clinical and Game-based Rehabilitation for Balance Impairments and Gaze Dysfunction in Clients With Vestibular Disorders Unknown status NCT02134444
12 Recovery of Visual Acuity in Vestibular Deficits Completed NCT00411216
13 Home-based Computer Gaming in Vestibular Rehabilitation: Effects on Gaze and Balance Impairment Completed NCT01943955
14 Clinical Evaluation of a Novel Balance, Vestibular and Oculomotor Assessment Tool Completed NCT02171312
15 Spatial Orientation and Vestibular Function in Patients With Acute or Chronic Unilateral Vestibular Deficits and in Patients With Bilateral Vestibular Deficits Completed NCT02212847
16 Clinical Study of Endolymphatic Sac Drainage With or Without Steroids for Intractable Meniere's Disease Completed NCT00500474
17 Which Treatment is Most Effective When Treating Vestibular Neuritis: Corticosteroid Treatment Alone or Combined Corticosteroid Treatment and Vestibular Rehabilitation? Recruiting NCT03821155 Corticosteroid
18 Positive Diagnosis of Vestibular Neuritis Using Fluid Attenuated Inversion Recuperation (FLAIR) Sequence, One Hour After Intravenous Gadolinium Injection, on a 1.5 Tesla Recruiting NCT03452410
19 Production of a Device to Obtain Continuous Ambulatory Vestibular Assessment (CAVA) - Dizziness Trial Recruiting NCT04026516
20 Assessment and Treatment of Patients With Long-term Dizziness in Primary Care Recruiting NCT02655575
21 Acute Video-oculography for Vertigo in Emergency Rooms for Rapid Triage (AVERT) Recruiting NCT02483429
22 Vestibulopathy With Vestibulo Ocular Reflex (VOR) Gain Deficit - Characteristics of Overt and Covert Saccadic Eye Movements Measured by the Video Head Impulse Test (vHIT) Not yet recruiting NCT03271775

Search NIH Clinical Center for Vestibular Neuronitis

Cochrane evidence based reviews: vestibular neuronitis

Genetic Tests for Vestibular Neuronitis

Anatomical Context for Vestibular Neuronitis

MalaCards organs/tissues related to Vestibular Neuronitis:

41
Testes, Eye, Bone, Brain, Neutrophil, T Cells, Pons

Publications for Vestibular Neuronitis

Articles related to Vestibular Neuronitis:

(show top 50) (show all 875)
# Title Authors PMID Year
1
Recovery of ocular and cervical vestibular evoked myogenic potentials after treatment of inner ear diseases. 38
31070081 2019
2
The Interrelations Between Different Causes of Dizziness: A Conceptual Framework for Understanding Vestibular Disorders. 38
31018648 2019
3
Why and when to refer patients for vestibular evoked myogenic potentials: A critical review. 38
31299589 2019
4
Mean platelet volume, neutrophil- and platelet to lymphocyte ratios are elevated in vestibular neuritis. 38
31202637 2019
5
[How to initially screen common central "malignant vertigo" at the bedside?] 38
31434383 2019
6
Vestibular Neurectomy for Intractable Vertigo: Case Series and Evaluation of Role of Endoscopic Assistance in Retrolabyrinthine Craniotomy. 38
31328081 2019
7
Direction-Changing and Direction-Fixed Positional Nystagmus in Patients With Vestibular Neuritis and Meniere Disease. 38
30509014 2019
8
Power spectra prognostic aspects of impulsive eye movement traces in superior vestibular neuritis. 38
31055714 2019
9
Mean platelet volume values may not be elevated in patients with vestibular neuritis. 38
31427234 2019
10
Clinical Characteristics of Acute Vestibular Neuritis According to Involvement Site. 38
30964776 2019
11
Dizziness demystified. 38
31326945 2019
12
Myocardial injury in transient global amnesia: a case-control study. 38
30706590 2019
13
The Price of Immune Responses and the Role of Vitamin D in the Inner Ear. 38
31194714 2019
14
Results in caloric test, video head impulse test and inner ear MRI in patients with Ménière's disease. 38
31272843 2019
15
A Case of Isolated Nodular Infarction Mimicking Vestibular Neuritis on the Contralateral Side. 38
31234246 2019
16
Utricular function in vestibular neuritis: a pilot study of concordance/discordance between ocular vestibular evoked myogenic potentials and ocular cycloposition. 38
30915492 2019
17
[The clinical effects of methylprednisolone combined with vestibular rehabilitation and methylprednisolone in the treatment of vestibular neuritis]. 38
31163519 2019
18
Acute vestibular asymmetry disorder: a new disease entity in acute vestibular syndrome? 38
31035836 2019
19
Dissociation of caloric and head impulse tests: a marker of Meniere's disease. 38
31222419 2019
20
Demographic data and seasonal variation in peripheral vestibular disorders in ENT practices in Germany. 38
31256098 2019
21
[Vertigo in children:composition and clinical characteristics]. 38
31163516 2019
22
Detection of intralabyrinthine abnormalities using post-contrast delayed 3D-FLAIR MRI sequences in patients with acute vestibular syndrome. 38
30413960 2019
23
Risk Factors for Tinnitus in 37,692 Patients Followed in General Practices in Germany. 38
30870350 2019
24
Risk of traffic accidents after onset of vestibular disease assessed with a surrogate marker. 38
30963255 2019
25
[The characteristics of semicircular canal injury frequency in vestibular neuritis patients]. 38
30813688 2019
26
Steroids for Acute Vestibular Neuronitis-the Earlier the Treatment, the Better the Outcome? 38
30681432 2019
27
[Analysis of clinical features of secondary benign paroxysmal positional vertigo]. 38
30813689 2019
28
Acute Dizziness. 38
30743290 2019
29
Risk Factors for Tinnitus in 37,692 Patients Followed in General Practices in Germany. 38
30789569 2019
30
Long-term clinical outcome in vestibular neuritis. 38
30566414 2019
31
Do steroids improve recovery in vestibular neuritis? 38
30467868 2019
32
Peripheral vestibular disorders: an update. 38
30562267 2019
33
Diagnostic value of eye movement and vestibular function tests in patients with posterior circulation infarction. 38
30767619 2019
34
The extent of vestibular impairment is important in recovery of canal paresis of patients with vestibular neuritis. 38
29866420 2019
35
Recovery Pattern of High-Frequency Acceleration Vestibulo-Ocular Reflex in Unilateral Vestibular Neuritis: A Preliminary Study. 38
30930826 2019
36
Functional Testing of Vestibulo-Spinal Contributions to Balance Control: Insights From Tracking Improvement Following Acute Bilateral Peripheral Vestibular Loss. 38
31191439 2019
37
High-Frequency Horizontal Semicircular Canal Function in Certain Menière's Disease. 38
29762197 2019
38
Competence of final year otolaryngology residents with the bedside head impulse test. 38
30658698 2019
39
The functional head impulse test: Comparing gain and percentage of correct answers. 38
31239135 2019
40
Vestibular Neuritis: Recent Advances in Etiology, Diagnostic Evaluation, and Treatment. 38
30947184 2019
41
Otolith Function Testing. 38
30947185 2019
42
Peripheral Vestibular Disorders: An Epidemiologic Survey in 70 Million Individuals. 38
30289843 2019
43
Comparison of acute vertigo diagnosis and treatment practices between otolaryngologists and non-otolaryngologists: A multicenter scenario-based survey. 38
30845218 2019
44
[Clinical significance of bedside dynamic visual acuity test]. 38
30584999 2018
45
Focal Degeneration of Vestibular Neuroepithelium in the Cristae Ampullares of Three Human Subjects. 38
30303940 2018
46
Video head impulse test results suggest that different pathomechanisms underlie sudden sensorineural hearing loss with vertigo and vestibular neuritis: Our experience in fifty-two patients. 38
30027648 2018
47
[Vestibular function features and prognosis of vestibular neuritis in children]. 38
30585000 2018
48
Correlation between vestibular neuritis and cerebrovascular risk factors. 38
30197156 2018
49
Spontaneous Canalith Jam and Apogeotropic Horizontal Canal Benign Paroxysmal Positional Vertigo: Considerations on a Particular Case Mimicking an Acute Vestibular Deficit. 38
30106853 2018
50
The functional head impulse test: preliminary data. 38
29868981 2018

Variations for Vestibular Neuronitis

Expression for Vestibular Neuronitis

Search GEO for disease gene expression data for Vestibular Neuronitis.

Pathways for Vestibular Neuronitis

GO Terms for Vestibular Neuronitis

Biological processes related to Vestibular Neuronitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription by RNA polymerase II GO:0006366 8.96 PIR KMT2A
2 central nervous system neuron differentiation GO:0021953 8.62 LMX1A CACNA1A

Molecular functions related to Vestibular Neuronitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metal ion binding GO:0046872 9.02 RTEL1 PIR LMX1A KMT2A CACNA1A

Sources for Vestibular Neuronitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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