MCID: VST001
MIFTS: 34

Vestibular Neuronitis

Categories: Ear diseases, Neuronal diseases

Aliases & Classifications for Vestibular Neuronitis

Summaries for Vestibular Neuronitis

Disease Ontology : 12 A inner ear infectious disease caused by a viral infection which involves inflammation of the vestibular nerve. It usually results as a complication of an upper respiratory infection. This causes sudden and severe vertigo, nausea and vomiting. Auditory symptoms are usually absent.

MalaCards based summary : Vestibular Neuronitis, also known as epidemic neurolabyrinthitis, is related to labyrinthitis and viral labyrinthitis. An important gene associated with Vestibular Neuronitis is RTEL1 (Regulator Of Telomere Elongation Helicase 1). The drugs Methylprednisolone and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include eye and testes, and related phenotypes are Synthetic lethal with vaccinia virus (VACV) infection and embryo

Wikipedia : 76 Labyrinthitis, also known as vestibular neuritis, is the inflammation of inner ear. It results in a... more...

Related Diseases for Vestibular Neuronitis

Diseases related to Vestibular Neuronitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 18)
# Related Disease Score Top Affiliating Genes
1 labyrinthitis 11.4
2 viral labyrinthitis 11.1
3 neuritis 10.7
4 neuronitis 10.6
5 vestibular nystagmus 9.9
6 vertigo, benign recurrent 9.7
7 aging 9.7
8 anxiety 9.7
9 vertebral artery occlusion 9.7
10 bell's palsy 9.7
11 acoustic neuroma 9.7
12 benign paroxysmal positional nystagmus 9.7
13 neuroma 9.7
14 pericoronitis 9.7
15 herpes simplex 9.7
16 neuropathy 9.7
17 encephalitis 9.7
18 vestibulocochlear nerve disease 6.2 CACNA1A GREM2 PIR RTEL1 SALL1 SLC9C1

Graphical network of the top 20 diseases related to Vestibular Neuronitis:



Diseases related to Vestibular Neuronitis

Symptoms & Phenotypes for Vestibular Neuronitis

GenomeRNAi Phenotypes related to Vestibular Neuronitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with vaccinia virus (VACV) infection GR00362-A 8.8 CACNA1A PIR SALL1

MGI Mouse Phenotypes related to Vestibular Neuronitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.26 PIR RTEL1 SALL1 TCOF1
2 growth/size/body region MP:0005378 9.1 CACNA1A GREM2 PIR RTEL1 SALL1 TCOF1

Drugs & Therapeutics for Vestibular Neuronitis

Drugs for Vestibular Neuronitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 39)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3 83-43-2 6741
2
Prednisolone Approved, Vet_approved Phase 4,Phase 3 50-24-8 5755
3
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
4 Antiemetics Phase 4,Phase 3
5 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2
6 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2
7 Autonomic Agents Phase 4,Phase 3
8 Gastrointestinal Agents Phase 4,Phase 3
9 glucocorticoids Phase 4,Phase 3,Phase 2
10 Hormone Antagonists Phase 4,Phase 3,Phase 2
11 Hormones Phase 4,Phase 3,Phase 2
12 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2
13 Methylprednisolone acetate Phase 4,Phase 3
14 Methylprednisolone Hemisuccinate Phase 4,Phase 3
15 Neuroprotective Agents Phase 4,Phase 3
16 Peripheral Nervous System Agents Phase 4,Phase 3
17 Prednisolone acetate Phase 4,Phase 3
18 Prednisolone hemisuccinate Phase 4,Phase 3
19 Prednisolone phosphate Phase 4,Phase 3
20 Protective Agents Phase 4,Phase 3
21 Anti-Asthmatic Agents Phase 4,Phase 3
22 Betamethasone benzoate Phase 4
23 Betamethasone sodium phosphate Phase 4
24 Betamethasone Valerate Phase 4 2152-44-5
25 Betamethasone-17,21-dipropionate Phase 4
26 Respiratory System Agents Phase 4,Phase 3
27
Cilostazol Approved, Investigational Phase 3 73963-72-1 2754
28 Bronchodilator Agents Phase 3
29 Fibrinolytic Agents Phase 3
30 Phosphodiesterase 3 Inhibitors Phase 3
31 Phosphodiesterase Inhibitors Phase 3
32 Platelet Aggregation Inhibitors Phase 3
33 Vasodilator Agents Phase 3
34 Ginkgo Nutraceutical Phase 3
35
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
36
Dexamethasone Approved, Investigational, Vet_approved Early Phase 1 50-02-2 5743
37
Menthol Approved Early Phase 1,Not Applicable 2216-51-5 16666
38 BB 1101 Early Phase 1
39 Dexamethasone acetate Early Phase 1 1177-87-3

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 Acute Unilateral Vestibulopathy and Corticosteroid Treatment Recruiting NCT02912182 Phase 4 Betamethasone;Placebo;Prednisolone
2 The Efficacy of Steroid Therapy in Vestibular Neuritis Unknown status NCT02098330 Phase 3 Ginkgo biloba & Methylprednisolone;Ginkgo biloba
3 Effect of Renexin Tablet in Patients With Recurrent Vestibulopathy Terminated NCT01895400 Phase 3 Renexin (cilostazol 100mg + gingko biloba extract 80 mg);Placebo
4 Prednisone Treatment for Vestibular Neuronitis Completed NCT00271791 Phase 2 Prednisone;Prednisone
5 Complementary/Alternative Medicine for Abnormality in the Vestibular (Balance) System Completed NCT00032383 Phase 1, Phase 2
6 The Role of Corticosteroids and Vestibular Exercises in Recovery of Vestibular Neuritis Unknown status NCT01231009 Early Phase 1 Corticosteroids
7 Characterisation of Cortical Vestibular Evoked Potentials (C-VEPs) Unknown status NCT02463695 Not Applicable
8 Vestibular System in Migrainous Vertigo Patients Unknown status NCT00901953
9 Game Based Vestibular Exercise for Home Rehabilitation Unknown status NCT02134444 Not Applicable
10 Recovery of Visual Acuity in People With Vestibular Deficits Completed NCT00411216 Not Applicable
11 Home-based Computer Gaming in Vestibular Rehabilitation Completed NCT01943955 Not Applicable
12 Clinical Evaluation of a Novel Balance, Vestibular and Oculomotor Assessment Tool Completed NCT02171312
13 Spatial Orientation and Vestibular Function Completed NCT02212847 Not Applicable
14 To Study the Characteristics of Different Types of Vertigo in Patients Attending the Ear Nose & Throat (ENT) Clinics. Completed NCT02213120
15 MRIPositive Diagnosis of Vestibular Neuritis Using Fluid Attenuated Inversion Recuperation (FLAIR) Sequence on a 1.5 Tesla Recruiting NCT03452410
16 Assessment and Treatment of Patients With Long-term Dizziness in Primary Care Recruiting NCT02655575 Not Applicable
17 Acute Video-oculography for Vertigo in Emergency Rooms for Rapid Triage (AVERT) Recruiting NCT02483429 Not Applicable
18 Simultaneous Recordings of Cervical and Ocular Vestibular-evoked Myogenic Potentials Enrolling by invitation NCT03049683
19 Vestibulopathy With Vestibulo Ocular Reflex (VOR) Gain Deficit Not yet recruiting NCT03271775 Not Applicable

Search NIH Clinical Center for Vestibular Neuronitis

Cochrane evidence based reviews: vestibular neuronitis

Genetic Tests for Vestibular Neuronitis

Anatomical Context for Vestibular Neuronitis

MalaCards organs/tissues related to Vestibular Neuronitis:

41
Eye, Testes

Publications for Vestibular Neuronitis

Articles related to Vestibular Neuronitis:

(show top 50) (show all 78)
# Title Authors Year
1
Bell's palsy and vestibular neuronitis. ( 25015516 )
2014
2
Investigation of seasonal variability of vestibular neuronitis. ( 24063368 )
2013
3
Vestibular evoked myogenic potentials in vestibular neuronitis. ( 22368986 )
2011
4
Comorbid intracranial vertebral artery asymmetry as a risk factor for severe vestibular neuronitis. ( 21317672 )
2011
5
Herpes simplex virus type 1 in saliva of patients with vestibular neuronitis: a preliminary study. ( 22045284 )
2011
6
Treatment of acute vestibular neuronitis with glucocorticoids. ( 21817947 )
2011
7
Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Bet 1: steroids for patients with vestibular neuronitis. ( 19850811 )
2009
8
[Late and sudden recovery of sudden deafness or vestibular neuronitis]. ( 17692812 )
2007
9
Herpes encephalitis preceded by ipsilateral vestibular neuronitis. ( 16246566 )
2005
10
A prospective study on the course of anxiety after vestibular neuronitis. ( 15046973 )
2004
11
Vestibular neuronitis in pilots: follow-up results and implications for flight safety. ( 12567089 )
2003
12
Lipoprotein (a) and acute-phase response in patients with vestibular neuronitis. ( 14636287 )
2003
13
Vestibular neuronitis: a viral neuropathy. ( 12077899 )
2002
14
Vestibular neuronitis in children: study of medium and long term follow-up. ( 10967381 )
2000
15
Vestibular neuronitis. ( 10431900 )
1999
16
The pathology of facial and vestibular neuronitis. ( 10442771 )
1999
17
Vestibular neuronal function of cats following unilateral vertebral artery occlusion. ( 9657307 )
1998
18
A proposal for introducing a modified vestibular index in neurotology. The classification of vestibular neuronitis. ( 8891479 )
1996
19
Comparative study on gait abnormality in patients with vestibular neuronitis and patients with large acoustic neuroma. ( 7610866 )
1995
20
Central disorders in vestibular neuronitis. ( 7610868 )
1995
21
A case with symptoms of vestibular neuronitis caused by an intramedullary lesion. ( 7642999 )
1995
22
Enhanced MRI in patients with vestibular neuronitis. ( 7610885 )
1995
23
Vestibular neuronitis in aged patients: results from an epidemiological survey by questionnaire in Japan. ( 8470501 )
1993
24
Vestibular neuronitis: epidemiological survey by questionnaire in Japan. ( 8470507 )
1993
25
Follow-up of square drawing test in vestibular neuronitis. ( 8470497 )
1993
26
A clinical observation of benign paroxysmal positional vertigo (BPPV) after vestibular neuronitis (VN). ( 8470503 )
1993
27
Vestibular neuronitis in children. ( 8470500 )
1993
28
Vestibular compensation in vestibular neuronitis: evaluation of positional nystagmus and caloric nystagmus. ( 8470494 )
1993
29
Relationship between GBST and equilibrium examination in vestibular neuronitis. ( 8470491 )
1993
30
Vestibular neuronitis. Proceedings of an international symposium on vestibular ganglia and vestibular neuronitis. Yamaguchi, Japan, 14-16 September, 1991. ( 8470473 )
1993
31
Progress of caloric response of vestibular neuronitis. ( 8470487 )
1993
32
Prolonged dysequilibrium in three cases with vestibular neuronitis: efficacy of vestibular rehabilitation. ( 8470498 )
1993
33
Vestibular compensation in vestibular neuronitis. Long-term follow-up evaluation. ( 8379299 )
1993
34
Serum viral antibody titer in vestibular neuronitis. ( 8385868 )
1993
35
Bilateral vestibular neuronitis. ( 8470502 )
1993
36
Vestibular neuronitis: a review of a common cause of vertigo in general practice. ( 8323804 )
1993
37
Neuroborreliosis in the etiology of vestibular neuronitis. ( 8470505 )
1993
38
Interpretation of the combined galvanic test. Findings from cases with vestibular neuronitis. ( 8470490 )
1993
39
Clinical observation of 32 cases of vestibular neuronitis. ( 8470478 )
1993
40
Vestibular neuronitis evaluated by the combined galvanic test. ( 8470489 )
1993
41
A clinical study of vestibular neuronitis. ( 1897712 )
1991
42
Compensatory process of vestibular neuronitis. From findings of combined galvanic test and caloric test. ( 1927436 )
1991
43
Temporal pattern of nerve growth factor (NGF) binding in vivo and the in vitro effects of NGF on cultures of developing auditory and vestibular neurons. ( 1648856 )
1991
44
Serovirological study of vestibular neuronitis. ( 2635537 )
1989
45
Vestibular neuronitis. Pathogenesis in the view of virological study of CSF. ( 2635536 )
1989
46
Vestibular neuronitis. An otoneurological evaluation. ( 3068952 )
1988
47
Vestibular neuronitis in childhood. ( 3245418 )
1988
48
Vestibular neuronitis--serum and CSF virus antibody titer. ( 3017280 )
1986
49
Neurotologic evidence of central and peripheral involvement in patients with vestibular neuronitis. ( 3931027 )
1985
50
Vestibular neuronitis: the experience at Harare Central Hospital, Zimbabwe: case report. ( 4076038 )
1985

Variations for Vestibular Neuronitis

Expression for Vestibular Neuronitis

Search GEO for disease gene expression data for Vestibular Neuronitis.

Pathways for Vestibular Neuronitis

GO Terms for Vestibular Neuronitis

Molecular functions related to Vestibular Neuronitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ion channel activity GO:0005216 8.62 CACNA1A SLC9C1

Sources for Vestibular Neuronitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....