Aliases & Classifications for Villonodular Synovitis

MalaCards integrated aliases for Villonodular Synovitis:

Name: Villonodular Synovitis 12 15 73
Pigmented Villonodular Synovitis 73

Classifications:



External Ids:

Disease Ontology 12 DOID:9898
ICD10 33 M12.20 M12.2
ICD9CM 35 719.2 719.20
UMLS 73 C0158168

Summaries for Villonodular Synovitis

MalaCards based summary : Villonodular Synovitis, also known as pigmented villonodular synovitis, is related to pigmented villonodular synovitis and bone giant cell tumor, and has symptoms including pain, arthralgia and other symptoms referable to joint. An important gene associated with Villonodular Synovitis is MMP9 (Matrix Metallopeptidase 9), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Endometrial cancer. The drugs Antibodies and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and lung, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Villonodular Synovitis

Diseases related to Villonodular Synovitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 78)
# Related Disease Score Top Affiliating Genes
1 pigmented villonodular synovitis 32.2 ACP5 MMP9 PTPN11 TNFSF11
2 bone giant cell tumor 29.9 ACP5 VIM
3 giant cell tumor 29.7 MMP9 TNFSF11 VIM
4 osteonecrosis 29.5 ACP5 TNFSF11
5 rheumatoid arthritis 27.8 ACP5 MMP9 TNFSF11
6 noonan syndrome 1 12.0
7 synovitis 11.3
8 noonan syndrome 4 11.2
9 tenosynovial giant cell tumor 10.5
10 noonan syndrome 3 10.4 PTPN11 SOS1
11 pulmonary valve stenosis 10.4 PTPN11 SOS1
12 pulmonary valve disease 10.4 PTPN11 SOS1
13 arthritis 10.3
14 pulmonic stenosis 10.3 PTPN11 SOS1
15 costello syndrome 10.3 PTPN11 SOS1
16 synovial chondromatosis 10.3
17 cardiofaciocutaneous syndrome 1 10.2 PTPN11 SOS1
18 gingival hypertrophy 10.2 MMP9 VIM
19 popliteal cyst 10.1
20 sarcoma 10.1
21 malignant giant cell tumor 10.1
22 synovium cancer 10.1
23 neuropathy 10.1
24 odontogenic myxoma 10.1 MMP9 VIM
25 fibromatosis 10.1 SOS1 VIM
26 enchondromatosis, multiple, ollier type 10.1 ACP5 PTPN11
27 carpal tunnel syndrome 10.1
28 mononeuropathy of the median nerve, mild 10.1
29 osteoarthritis 10.1
30 hemarthrosis 10.1
31 pneumothorax 10.0 MMP9 VIM
32 spondyloarthropathy 1 9.9
33 systemic lupus erythematosus 9.9
34 chediak-higashi syndrome 9.9
35 sarcoma, synovial 9.9
36 tendinitis 9.9
37 hemangioma 9.9
38 lymphoma 9.9
39 squamous cell carcinoma 9.9
40 melanoma 9.9
41 cervicitis 9.9
42 chondroblastoma 9.9
43 nodular tenosynovitis 9.9
44 malignant giant cell tumor of the tendon sheath 9.9
45 peroneal neuropathy 9.9
46 ulnar neuropathy 9.9
47 paraplegia 9.9
48 epithelioid sarcoma 9.9
49 conjunctivitis 9.9
50 spondylitis 9.9

Graphical network of the top 20 diseases related to Villonodular Synovitis:



Diseases related to Villonodular Synovitis

Symptoms & Phenotypes for Villonodular Synovitis

UMLS symptoms related to Villonodular Synovitis:


pain, arthralgia, other symptoms referable to joint, stiffness of joint, not elsewhere classified in icd10cm

GenomeRNAi Phenotypes related to Villonodular Synovitis according to GeneCards Suite gene sharing:

26 (show all 14)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 9.47 VIM
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-142 9.47 TNFSF11
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.47 TNFSF11
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.47 SOS1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.47 SOS1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-175 9.47 TNFSF11
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.47 TNFSF11
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-203 9.47 SOS1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-212 9.47 VIM
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.47 SOS1
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.47 SOS1
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.47 SOS1 TNFSF11 VIM
13 Decreased cell migration GR00055-A-1 9.33 ACP5 SOS1 VIM
14 Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance GR00210-A 9.13 ACP5 PTPN11 VIM

MGI Mouse Phenotypes related to Villonodular Synovitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.65 MMP9 PTPN11 SOS1 TNFSF11 VIM
2 muscle MP:0005369 9.55 MMP9 PTPN11 SOS1 TNFSF11 VIM
3 respiratory system MP:0005388 9.26 MMP9 PTPN11 TNFSF11 VIM
4 vision/eye MP:0005391 9.02 MMP9 PTPN11 SOS1 TNFSF11 VIM

Drugs & Therapeutics for Villonodular Synovitis

Drugs for Villonodular Synovitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies Phase 1, Phase 2
2 Immunoglobulins Phase 1, Phase 2
3 Grapefruit Seed Extract Nutraceutical Phase 2
4
Paclitaxel Approved, Vet_approved Phase 1 33069-62-4 36314
5 Albumin-Bound Paclitaxel Phase 1
6 Antimitotic Agents Phase 1
7 Antineoplastic Agents, Phytogenic Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase 3 Study of Pexidartinib for Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCT-TS) Active, not recruiting NCT02371369 Phase 3 Pexidartinib;Placebo
2 Study of Nilotinib Efficacy in Pigmented Villo-Nodular Synovitis/ Tenosynovial Giant Cell Tumour (PVNS/TGCT) Completed NCT01261429 Phase 2 Tasigna
3 Study of Cabiralizumab in Patients With Pigmented Villonodular Synovitis / Diffuse Type Tenosynovial Giant Cell Tumor Recruiting NCT02471716 Phase 1, Phase 2
4 MCS110 in Patients With Pigmented Villonodular Synovitis (PVNS) Active, not recruiting NCT01643850 Phase 2 MCS110;Placebo;MCS110;Placebo
5 Nilotinib in Patients With Relapsed or Metastatic Pigmented Villonodular Synovitis/Tenosynovial Giant Cell Tumor/Diffuse-Type Giant Cell Tumor Active, not recruiting NCT01207492 Phase 2 nilotinib
6 A Study of RO5509554 as Monotherapy and in Combination With Paclitaxel in Participants With Advanced Solid Tumors Completed NCT01494688 Phase 1 Paclitaxel;RO5509554
7 Evaluation of the Effectiveness of Surgical Treatment of Villo-nodular Synovitis of the Hip in Children Recruiting NCT03507933
8 Tenosynovial Giant Cell Tumors (TGCT) Observational Platform Project Recruiting NCT02948088

Search NIH Clinical Center for Villonodular Synovitis

Genetic Tests for Villonodular Synovitis

Anatomical Context for Villonodular Synovitis

MalaCards organs/tissues related to Villonodular Synovitis:

41
Bone, Testes, Lung

Publications for Villonodular Synovitis

Articles related to Villonodular Synovitis:

(show top 50) (show all 630)
# Title Authors Year
1
Recurrent pigmented villonodular synovitis of the temporomandibular joint. ( 29904498 )
2018
2
Pigmented villonodular synovitis managed by total synovectomy and cementless total hip arthroplasty. ( 29700612 )
2018
3
Diffuse Pigmented Villonodular Synovitis Around the Ankle. ( 29634303 )
2018
4
Arthroscopic Management of Pigmented Villonodular Synovitis of the Hip in Children and Adolescents. ( 29594178 )
2018
5
Pigmented Villonodular Synovitis: A Close Mimic of Metastasis on<sup>18</sup>F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography. ( 29430127 )
2018
6
Nilotinib in locally advanced pigmented villonodular synovitis: challenges of a new targeted therapy. ( 29571947 )
2018
7
Distinct extra-articular invasion patterns of diffuse pigmented villonodular synovitis/tenosynovial giant cell tumor in the knee joints. ( 29637236 )
2018
8
Pigmented Villonodular Synovitis of the Knee: An Underappreciated Source of Pain in Children and Adolescents. ( 29917011 )
2018
9
Necessity of adjuvant postoperative radiotherapy for diffuse pigmented villonodular synovitis of the knee: A case report and literature review. ( 29504995 )
2018
10
Pigmented villonodular synovitis in pediatric population: review of literature and a case report. ( 29343257 )
2018
11
Arthroscopic Treatment of Diffuse Pigmented Villonodular Synovitis of the Knee: Complete Synovectomy and Septum Removal-Midterm Results. ( 29727868 )
2018
12
Nilotinib in locally advanced pigmented villonodular synovitis: a multicentre, open-label, single-arm, phase 2 trial. ( 29571946 )
2018
13
Computed Tomography Findings of Pigmented Villonodular Synovitis in a Dog. ( 29864767 )
2018
14
Lowering the recurrence rate in pigmented villonodular synovitis: A series of 120 resections. ( 29788491 )
2018
15
Localized pigmented villonodular synovitis of the ankle: Expect the unexpected. ( 28159047 )
2017
16
Open and Arthroscopic with Mini-Open Surgical Hip Approaches for Treatment of Pigmented Villonodular Synovitis and Concomitant Hip Pathology. ( 28326214 )
2017
17
Surgical treatment for diffused-type giant cell tumor (pigmented villonodular synovitis) about the ankle joint. ( 29137617 )
2017
18
Multifocal pigmented villonodular synovitis coexisting in both the knee joint and the patella: a case report and literature review. ( 28683727 )
2017
19
Localized pigmented villonodular synovitis of posterior compartment of the knee. ( 28847242 )
2017
20
Arthroscopic treatment of intra-artricularly localised pigmented villonodular synovitis of the ankle: 4 cases with long-term follow-up. ( 29202997 )
2017
21
Localized and diffuse forms of tenosynovial giant cell tumor (formerly giant cell tumor of the tendon sheath and pigmented villonodular synovitis). ( 28057477 )
2017
22
PIGMENTED VILLONODULAR SYNOVITIS IN A RETICULATED GIRAFFE (GIRAFFA CAMELOPARDALIS). ( 28749260 )
2017
23
Diffuse Pigmented Villonodular Synovitis as a Rare Cause of Graft Failure Following Anterior Cruciate Ligament Reconstruction. ( 28776631 )
2017
24
An unusual case of diffuse pigmented villonodular synovitis of the shoulder: A multidisciplinary approach with arthroscopic synovectomy and adjuvant radiotherapy. ( 28638690 )
2017
25
Long-Term Outcome of Hip Arthroplasty in the Setting of Pigmented Villonodular Synovitis. ( 29352684 )
2017
26
A rare case of localised pigmented villonodular synovitis in the knee of a 24-year-old female soccer player: diagnosis, management and summary of tenosynovial giant cell tumours. ( 28978573 )
2017
27
Long-term outcome of knee arthroplasty in the setting of pigmented villonodular synovitis. ( 28552192 )
2017
28
Total knee replacement in patients with diffuse villonodular synovitis. ( 29062829 )
2017
29
Long-term outcome of pigmented villonodular synovitis of the hip after joint preserving therapy. ( 29282525 )
2017
30
Systematic Arthroscopic Treatment of Diffuse Pigmented Villonodular Synovitis in the Knee. ( 29354472 )
2017
31
Results and recurrence of pigmented villonodular synovitis of the ankle: does diffuse PVNS with extra-articular extension tend to recur more often? ( 28389877 )
2017
32
Diffuse pigmented villonodular synovitis in knee joint: diagnosis and treatment. ( 28884104 )
2017
33
All-Arthroscopic Treatment of Intra- and Extra-Articular Localized Villonodular Synovitis of Knee. ( 29270551 )
2017
34
Pigmented villonodular synovitis of the knee: A retrospective analysis of 214 cases at a UK tertiary referral centre. ( 28442184 )
2017
35
Localized pigmented villonodular synovitis in a child knee. ( 28291439 )
2017
36
Pigmented Villonodular Synovitis of the Temporomandibular Joint With Petrous Bone Invasion. ( 28333775 )
2017
37
Intra-articular Localized Haemangioma of the Knee Mimicking Localized Pigmented Villonodular Synovitis: A Case Report. ( 28435577 )
2017
38
Pigmented Villonodular Synovitis of Thumb-A Cytological Diagnosis. ( 28764182 )
2017
39
Pigmented Villonodular Synovitis - Various Manifestations, Inconsistent Terminology and Treatment. Cases Study. ( 28436371 )
2017
40
Pigmented Villonodular Synovitis of the Hip: A Systematic Review. ( 26761914 )
2016
41
Locked hip joint: an uncommon presentation of localized pigmented villonodular synovitis. ( 27130398 )
2016
42
Villonodular synovitis shoulder complicated by rotator cuff rupture. ( 27068614 )
2016
43
Pigmented Villonodular Synovitis: A Comprehensive Review and Proposed Treatment Algorithm. ( 27509331 )
2016
44
Tumorlike Pigmented Villonodular Synovitis With Atypical Location: Appearance on 3-Phase 99mTc-MDP Bone Scan. ( 28005642 )
2016
45
Arthroscopically-assisted mini open partial synovectomy for the treatment of localized pigmented villonodular synovitis of the knee. A retrospective comparative study with long-term follow up. ( 27866235 )
2016
46
Pigmented villonodular synovitis of the hip. ( 28461957 )
2016
47
Arthroscopic surgical treatment of pigmented villonodular synovitis of the elbow: case report. ( 27517031 )
2016
48
Osteonecrosis of the femoral head associated with pigmented villonodular synovitis. ( 27928593 )
2016
49
Pigmented villonodular synovitis: a crowdsourcing study of two hundred and seventy two patients. ( 27169531 )
2016
50
Functional Reconstruction of Temporomandibular Joint after Resection of Pigmented Villonodular Synovitis with Extension to Infratemporal Fossa and Skull Base: A Case Report. ( 28824995 )
2016

Variations for Villonodular Synovitis

Expression for Villonodular Synovitis

Search GEO for disease gene expression data for Villonodular Synovitis.

Pathways for Villonodular Synovitis

Pathways related to Villonodular Synovitis according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.66 MMP9 PTPN11 SOS1 TNFSF11 VIM
2
Show member pathways
12.54 MMP9 PTPN11 SOS1
3 12.18 MMP9 SOS1 VIM
4
Show member pathways
12.14 PTPN11 SOS1 TNFSF11
5
Show member pathways
12.04 PTPN11 SOS1 VIM
6 11.8 MMP9 PTPN11 SOS1
7
Show member pathways
11.61 PTPN11 SOS1
8
Show member pathways
11.57 PTPN11 SOS1
9 11.56 ACP5 TNFSF11
10 11.48 MMP9 PTPN11
11
Show member pathways
11.42 PTPN11 SOS1
12
Show member pathways
11.37 PTPN11 SOS1
13 11.31 PTPN11 SOS1
14 11.27 PTPN11 SOS1
15 11.2 PTPN11 SOS1
16 11.18 PTPN11 SOS1
17 11.12 PTPN11 SOS1
18
Show member pathways
11.07 PTPN11 SOS1 TNFSF11
19 11.01 PTPN11 SOS1
20
Show member pathways
10.95 PTPN11 SOS1
21 10.88 PTPN11 SOS1
22 10.82 MMP9 SOS1
23 10.77 PTPN11 SOS1
24 10.47 MMP9 PTPN11 SOS1
25 10.46 ACP5 TNFSF11

GO Terms for Villonodular Synovitis

Biological processes related to Villonodular Synovitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ossification GO:0001503 9.48 MMP9 TNFSF11
2 ephrin receptor signaling pathway GO:0048013 9.46 MMP9 PTPN11
3 multicellular organism growth GO:0035264 9.43 PTPN11 SOS1
4 leukocyte migration GO:0050900 9.43 MMP9 PTPN11 SOS1
5 epidermal growth factor receptor signaling pathway GO:0007173 9.4 PTPN11 SOS1
6 positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 9.37 MMP9 SOS1
7 bone resorption GO:0045453 9.32 ACP5 TNFSF11
8 neurotrophin TRK receptor signaling pathway GO:0048011 9.16 PTPN11 SOS1
9 cytokine-mediated signaling pathway GO:0019221 9.02 MMP9 PTPN11 SOS1 TNFSF11 VIM
10 Bergmann glial cell differentiation GO:0060020 8.96 PTPN11 VIM

Sources for Villonodular Synovitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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