Aliases & Classifications for Villonodular Synovitis

MalaCards integrated aliases for Villonodular Synovitis:

Name: Villonodular Synovitis 12 15 70 32
Pigmented Villonodular Synovitis 70

Classifications:



External Ids:

Disease Ontology 12 DOID:9898
ICD9CM 34 719.2
SNOMED-CT 67 34671005
ICD10 32 M12.2 M12.20
UMLS 70 C0039106 C0158168

Summaries for Villonodular Synovitis

MalaCards based summary : Villonodular Synovitis, also known as pigmented villonodular synovitis, is related to synovitis and pigmented villonodular synovitis, and has symptoms including arthralgia, pain and other symptoms referable to joint. An important gene associated with Villonodular Synovitis is CD68 (CD68 Molecule), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Sargramostim and Olaparib have been mentioned in the context of this disorder. Affiliated tissues include bone, heart and skin, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 73 Villonodular synovitis is a type of synovial... more...

Related Diseases for Villonodular Synovitis

Diseases related to Villonodular Synovitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 186)
# Related Disease Score Top Affiliating Genes
1 synovitis 31.6 MMP9 MMP1 CD68 ACP5
2 pigmented villonodular synovitis 31.4 PTPRC PTPN11 MMP9 CSF1 CD68 ACP5
3 tenosynovial giant cell tumor 30.7 CSF1 CD68
4 noonan syndrome and noonan-related syndrome 30.3 SOS1 PTPN11
5 benign giant cell tumor 30.2 PTPRC MMP9 CSF1
6 bone giant cell tumor 29.8 CSF1 CD68 ACP5
7 multicentric reticulohistiocytosis 29.7 CSF1 CD68
8 arthritis 29.5 MMP9 MMP1 CSF1 ACP5
9 rheumatoid arthritis 29.4 MMP9 MMP1 CSF1 ACP5
10 nodular tenosynovitis 29.2 PTPRC CSF1 CD68 ACP5
11 noonan syndrome 1 11.6
12 plica syndrome 11.5
13 noonan syndrome 4 11.2
14 hemarthrosis 10.6
15 synovial chondromatosis 10.6
16 tenosynovitis 10.6
17 bursitis 10.5
18 frozen shoulder 10.5
19 arthropathy 10.5
20 sarcoma, synovial 10.5
21 popliteal cyst 10.5
22 soft tissue sarcoma 10.4
23 osteonecrosis 10.4
24 juvenile rheumatoid arthritis 10.4
25 malignant giant cell tumor 10.3
26 hemangioma 10.3
27 septic arthritis 10.3
28 synovial angioma 10.3
29 chromosomal triplication 10.3
30 spindle cell sarcoma 10.2
31 sarcoma 10.2
32 triiodothyronine receptor auxiliary protein 10.2
33 osteoarthritis 10.2
34 neuropathy 10.2
35 hemophilia 10.2
36 pseudo-turner syndrome 10.2
37 avascular necrosis 10.2
38 rare tumor 10.2
39 keratosis pilaris atrophicans faciei 10.2 SOS1 PTPN11
40 noonan syndrome-like disorder with loose anagen hair 2 10.2 SOS1 PTPN11
41 noonan syndrome-like disorder with loose anagen hair 10.2 SOS1 PTPN11
42 pulmonary valve disease 10.2 SOS1 PTPN11
43 neurofibromatosis-noonan syndrome 10.2 SOS1 PTPN11
44 pulmonary valve stenosis 10.2 SOS1 PTPN11
45 gingival hypertrophy 10.2 SOS1 MMP9
46 synovium neoplasm 10.2
47 mammary paget's disease 10.2
48 fibrous histiocytoma 10.2
49 exostosis 10.2
50 melanoma 10.2

Graphical network of the top 20 diseases related to Villonodular Synovitis:



Diseases related to Villonodular Synovitis

Symptoms & Phenotypes for Villonodular Synovitis

UMLS symptoms related to Villonodular Synovitis:


arthralgia; pain; other symptoms referable to joint; stiffness of joint, not elsewhere classified in icd10cm

GenomeRNAi Phenotypes related to Villonodular Synovitis according to GeneCards Suite gene sharing:

26 (show all 20)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-100 9.66 SOS1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-105 9.66 PTPRC
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-118 9.66 PTPN11
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-120 9.66 SOS1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-121 9.66 PTPN11
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-138 9.66 PTPN11
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-142 9.66 CSF1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-149 9.66 PTPN11 SOS1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.66 PTPRC
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.66 CSF1
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-190 9.66 PTPN11
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-203 9.66 SOS1
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-37 9.66 PTPN11
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-41 9.66 PTPRC
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-47 9.66 CSF1 PTPN11
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.66 SOS1
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.66 PTPRC
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.66 CSF1
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-90 9.66 CSF1
20 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.66 CSF1

MGI Mouse Phenotypes related to Villonodular Synovitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.5 CD68 CSF1 MMP1 MMP9 PTPN11 PTPRC
2 skeleton MP:0005390 9.1 CD68 CSF1 MMP9 PTPN11 PTPRC SOS1

Drugs & Therapeutics for Villonodular Synovitis

Drugs for Villonodular Synovitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sargramostim Approved, Investigational Phase 3 123774-72-1, 83869-56-1
2
Olaparib Approved Phase 2 763113-22-0 23725625
3
Everolimus Approved Phase 2 159351-69-6 6442177 70789204
4
Sorafenib Approved, Investigational Phase 2 284461-73-0 216239 406563
5
Durvalumab Approved, Investigational Phase 2 1428935-60-7
6
Lapatinib Approved, Investigational Phase 2 231277-92-2, 388082-78-8 208908 9941095
7
Tremelimumab Investigational Phase 2 745013-59-6
8 Grapefruit Seed Extract Phase 2
9 Immunoglobulins Phase 1, Phase 2
10 Antibodies Phase 1, Phase 2
11 Antineoplastic Agents, Immunological Phase 2
12 Poly(ADP-ribose) Polymerase Inhibitors Phase 2
13 Immunosuppressive Agents Phase 2
14 Protein Kinase Inhibitors Phase 2
15 Immunologic Factors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Double-blind, Randomized, Placebo-controlled Phase 3 Study of Orally Administered PLX3397 in Subjects With Pigmented Villonodular Synovitis or Giant Cell Tumor of the Tendon Sheath Active, not recruiting NCT02371369 Phase 3 Pexidartinib;Placebo
2 A Phase II Randomized, Double -Blind, Placebo Controlled Study to Assess Safety, Tolerability and Effect on Tumor Size of MCS110 in Patients With Pigmented Villonodular Synovitis (PVNS) Completed NCT01643850 Phase 2 MCS110;Placebo
3 Phase II Study of Nilotinib Efficacy in Pigmented Villo-Nodular Synovitis/ Tenosynovial Giant Cell Tumour (PVNS/TGCT) Completed NCT01261429 Phase 2 Tasigna
4 A Phase 1/2 Study of Cabiralizumab, an Anti-CSF1 Receptor Antibody, in Patients With Pigmented Villonodular Synovitis (PVNS)/ Diffuse Type Tenosynovial Giant Cell Tumor (Dt-TGCT) Completed NCT02471716 Phase 1, Phase 2
5 A Two-period, Multicenter, Randomized, Open-label, Phase II Study Evaluating the Clinical Benefit of a Maintenance Treatment Targeting Tumor Molecular Alterations in Patients With Progressive Locally-advanced or Metastatic Solid Tumors Recruiting NCT02029001 Phase 2 Nilotinib (400 mg BID);Everolimus (10 mg QD);Sorafenib (400 mg BID);Lapatinib (1500 mg QD);Pazopanib (800 mg QD);Olaparib (300 mg BID)
6 A Multi-Center Single Agent Phase II Study of the Efficacy of Nilotinib in Patients With Relapsed or Metastatic Pigmented Villonodular Synovitis/Tenosynovial Giant Cell Tumor/Diffuse-Type Giant Cell Tumor Active, not recruiting NCT01207492 Phase 2 nilotinib
7 A Disease Registry for Patients With Tenosynovial Giant Cell Tumors (TGCT), Also Known as Pigmented Villonodular Synovitis (PVNS) and Giant Cell Tumor of the Tendon Sheath (GCT-TS) Active, not recruiting NCT02948088

Search NIH Clinical Center for Villonodular Synovitis

Genetic Tests for Villonodular Synovitis

Anatomical Context for Villonodular Synovitis

MalaCards organs/tissues related to Villonodular Synovitis:

40
Bone, Heart, Skin, Endothelial, Neutrophil, Lymph Node, Tonsil

Publications for Villonodular Synovitis

Articles related to Villonodular Synovitis:

(show top 50) (show all 1345)
# Title Authors PMID Year
1
99mTc-MDP 3-Phase Bone Imaging in 3 Cases of Pigmented Villonodular Synovitis. 61
33630800 2021
2
cIAP2 expression and clinical significance in pigmented villonodular synovitis. 61
33599891 2021
3
Modified Stoppa Approach: Beyond Acetabular Fractures: A Report of 2 Cases. 61
33798123 2021
4
Pigmented Villonodular Synovitis of the Hip in Patients Undergoing Total Hip Arthroplasty: A Retrospective Case-Controlled Analysis. 61
32978024 2021
5
Spinal pigmented villonodular synovitis and tenosynovial giant cell tumor: A report of two cases and a comprehensive systematic review. 61
33596487 2021
6
Long-term functional outcomes of diffuse pigmented villonodular synovitis of knee: The role of adjuvant radiotherapy. 61
33761628 2021
7
Subacromial pigmented villonodular synovitis: case report and review. 61
33732422 2021
8
The New Bern Chondrolabral Classification Is Reliable and Reproducible. 61
33787519 2021
9
Short-Term Outcomes of Synovectomy and Total Knee Replacement in Patients with Diffuse-Type Pigmented Villonodular Synovitis. 61
31434148 2021
10
Pigmented Villonodular Synovitis of the Flexor Hallucis Longus Tendon Treated by Means of Tendoscopy and Endoscopic Synovectomy. 61
33750654 2021
11
Subtalar joint pigmented villonodular synovitis misdiagnosed at the first visit: A case report. 61
33644205 2021
12
Systematic review: total knee arthroplasty (TKA) in patients with pigmented villonodular synovitis (PVNS). 61
33632334 2021
13
An abrupt-onset shoulder joint subluxation and pseudoparalysis caused by intraarticular pigmented villonodular synovitis: A case report. 61
33463448 2021
14
Open synovectomy treatment for intra- and extraarticular localized pigmented villonodular synovitis of the knee: a case report. 61
33413272 2021
15
Atypical and bilateral pigmented villonodular synovitis of wrist in an adolescent patient: case report and literature review. 61
33786156 2021
16
Pigmented Villonodular Synovitis of the Knee Joint in a 10-Year-Old Patient Treated With an All-Arthroscopic Synovectomy: A Case Report. 61
33425510 2020
17
Villonodular synovitis of the lumbar spine: Case report of a rare pathology. 61
33363737 2020
18
[Rheumatoid arthritis combined with pigmented villonodular synovitis: A case report and literature review]. 61
33331327 2020
19
Synovial Non-langerhans Cell Histiocytosis of the Shoulder: A Case Report and Review of the Literature. 61
33708700 2020
20
Chronic lymphoplasmacytic villonodular proliferative synovitis in a 10-year-old Jack Russell Terrier dog. 61
33282937 2020
21
Radioisotope Synoviorthesis in the Control of Refractory Synovitis in Castilla-La Mancha. A 10-year Experience. 61
30691947 2020
22
Prospects of Treating Tenosynovial Giant Cell Tumor through Pexidar-tinib: A Review. 61
33143617 2020
23
Management of Tenosynovial Giant Cell Tumor: A Neoplastic and Inflammatory Disease. 61
33156160 2020
24
Pigmented villonodular synovitis does not influence the outcomes following cruciate-retaining total knee arthroplasty: a case-control study with minimum 5-year follow-up. 61
32894157 2020
25
ENLIVEN study: Pexidartinib for tenosynovial giant cell tumor (TGCT). 61
32755241 2020
26
Concomitant Spondyloarthritis and Tenosynovial Giant Cell Tumor in Pigmented Villonodular Synovitis Challenging Cases. 61
30601200 2020
27
Pigmented Villonodular Synovitis Mimicking an Acute Septic Hip in an Eight-Year-Old Male. 61
32968561 2020
28
Pigmented villonodular synovitis of the hip joint: Three cases demonstrating characteristic MRI features. 61
32617126 2020
29
Acupuncture improves postoperative symptoms of pigmented villonodular synovitis: A protocol for systematic review and meta analysis. 61
32872065 2020
30
Pigmented Villonodular Synovitis: Novel Role of Dual-Energy CT. 61
30614893 2020
31
Dark as night: Spelunking for spinal solitary fibrous tumors/hemangiopericytomas in the differential of T2 hypointensity. 61
32507710 2020
32
Concurrence of Pigmented Villonodular Synovitis with Calcium Pyrophosphate Deposition in a Postacute Stroke Patient. 61
33282666 2020
33
Ozone therapy for the treatment of recurrent pigmented villonodular synovitis of the knee. 61
33004715 2020
34
Identification of Patient Needs and Preferences in Pigmented Villonodular Synovitis (PVNS) Using a Qualitative Online Bulletin Board Study. 61
32394210 2020
35
Management of Pigmented Villonodular Synovitis (PVNS): an Orthopedic Surgeon's Perspective. 61
32494892 2020
36
Mid-Term Results of Arthroscopic Synovectomy for Pigmented Villonodular Synovitis of the Hip. 61
32061973 2020
37
Efficacy of image-guided synovial biopsy. 61
31912178 2020
38
Spontaneous swelling of the ankle in a child : a difficult diagnosis. 61
33418627 2020
39
A Rare Case of Hip Pain Secondary to Pigmented Villonodular Synovitis. 61
32426678 2020
40
Recurrence of pigmented villonodular synovitis of the knee: A case report with review of literature on the risk factors causing recurrence. 61
32312009 2020
41
Pigmented villonodular synovitis after anterior cruciate ligament reconstruction using active bioprosthetic composite artificial ligament. 61
31820085 2020
42
Arthroscopic Technique for the Treatment of Localized Pigmented Villonodular Synovitis of the Knee. 61
32467807 2020
43
Intra-articular venous malformation of the knee in children: magnetic resonance imaging findings and significance of synovial involvement. 61
31853571 2020
44
Radiosynoviorthesis after Surgery in the Treatment of Patients with Ankle Pigmented Villonodular Synovitis: A Case Series. 61
32098290 2020
45
[Villonodular synovitis]. 61
32877134 2020
46
The results of 394 consecutive cases of knee joint radiation synovectomy (radiosynoviorthesis) using 90Y. 61
31721044 2020
47
Rapid destruction of shoulder joint by pigmented villonodular synovitis treated by hemiarthroplasty: A case report. 61
33160174 2020
48
Monoarticular synovitis of knee: dealing with the dilemma. 61
33306021 2020
49
[Diffuse pigmented villonodular synovitis with giant extraarticular mass:a case report]. 61
32115930 2020
50
Pigmented villonodular synovitis associated with developmental dysplasia of the hip: A case report. 61
32905924 2020

Variations for Villonodular Synovitis

Expression for Villonodular Synovitis

Search GEO for disease gene expression data for Villonodular Synovitis.

Pathways for Villonodular Synovitis

Pathways related to Villonodular Synovitis according to GeneCards Suite gene sharing:

(show all 38)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.61 SOS1 PTPRC PTPN11 MMP9 MMP1 CSF1
2
Show member pathways
13.03 SOS1 PTPN11 MMP9 MMP1 CSF1
3
Show member pathways
12.39 SOS1 PTPRC PTPN11
4
Show member pathways
12.37 SOS1 PTPRC PTPN11
5
Show member pathways
12.36 SOS1 PTPRC PTPN11
6
Show member pathways
12.24 SOS1 PTPRC PTPN11
7
Show member pathways
12.18 SOS1 PTPRC PTPN11
8 12.06 SOS1 PTPN11 MMP9
9
Show member pathways
12.04 SOS1 PTPN11 MMP1
10
Show member pathways
11.96 SOS1 PTPN11 MMP1
11 11.9 SOS1 MMP9 MMP1
12
Show member pathways
11.67 SOS1 PTPN11
13 11.67 PTPRC CSF1 CD68
14
Show member pathways
11.61 SOS1 PTPRC PTPN11
15
Show member pathways
11.53 SOS1 PTPRC PTPN11
16 11.47 MMP1 CSF1 ACP5
17 11.41 PTPRC PTPN11
18 11.4 SOS1 PTPN11
19 11.32 PTPN11 CSF1
20 11.31 PTPRC PTPN11 MMP9
21 11.3 SOS1 PTPN11
22 11.28 SOS1 PTPN11
23 11.23 MMP9 MMP1
24 11.22 SOS1 PTPN11
25 11.18 SOS1 CSF1
26 11.17 SOS1 PTPN11
27 11.15 MMP9 MMP1
28 11.12 SOS1 PTPN11
29 11.1 PTPRC MMP9
30
Show member pathways
11.07 SOS1 PTPN11
31 11.03 SOS1 PTPN11
32 10.99 SOS1 MMP9
33 10.96 SOS1 PTPN11
34 10.84 SOS1 PTPN11 MMP1
35 10.73 MMP9 MMP1
36 10.66 CSF1 CD68
37 10.47 SOS1 PTPN11 MMP9
38 9.76 SOS1 PTPN11

GO Terms for Villonodular Synovitis

Biological processes related to Villonodular Synovitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dephosphorylation GO:0016311 9.54 PTPRC PTPN11 ACP5
2 epidermal growth factor receptor signaling pathway GO:0007173 9.48 SOS1 PTPN11
3 collagen catabolic process GO:0030574 9.46 MMP9 MMP1
4 homeostasis of number of cells within a tissue GO:0048873 9.43 PTPN11 CSF1
5 positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 9.4 SOS1 MMP9
6 macrophage differentiation GO:0030225 9.32 MMP9 CSF1
7 neurotrophin TRK receptor signaling pathway GO:0048011 9.26 SOS1 PTPN11
8 leukocyte migration GO:0050900 9.26 SOS1 PTPN11 MMP9 MMP1
9 cellular response to UV-A GO:0071492 9.16 MMP9 MMP1
10 cytokine-mediated signaling pathway GO:0019221 9.02 SOS1 PTPN11 MMP9 MMP1 CSF1

Molecular functions related to Villonodular Synovitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity GO:0016787 9.02 PTPRC PTPN11 MMP9 MMP1 ACP5

Sources for Villonodular Synovitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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