Aliases & Classifications for Villonodular Synovitis

MalaCards integrated aliases for Villonodular Synovitis:

Name: Villonodular Synovitis 12 15 74
Pigmented Villonodular Synovitis 74

Classifications:



External Ids:

Disease Ontology 12 DOID:9898
ICD9CM 36 719.2 719.20
SNOMED-CT 69 34671005 95411002
ICD10 34 M12.2 M12.20

Summaries for Villonodular Synovitis

MalaCards based summary : Villonodular Synovitis, also known as pigmented villonodular synovitis, is related to pigmented villonodular synovitis and giant cell tumor, and has symptoms including arthralgia, pain and other symptoms referable to joint. An important gene associated with Villonodular Synovitis is MMP9 (Matrix Metallopeptidase 9), and among its related pathways/superpathways are Endometrial cancer and Cytokine Signaling in Immune system. The drugs Sargramostim and Grapefruit Seed Extract have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and neutrophil, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Villonodular Synovitis

Diseases related to Villonodular Synovitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 77)
# Related Disease Score Top Affiliating Genes
1 pigmented villonodular synovitis 33.5 ACP5 MMP9 PTPN11 TNFSF11
2 giant cell tumor 30.6 MMP9 TNFSF11 VIM
3 osteonecrosis 30.1 ACP5 TNFSF11
4 bone giant cell tumor 29.9 ACP5 TNFSF11
5 rheumatoid arthritis 29.6 ACP5 MMP9 TNFSF11
6 noonan syndrome 1 12.2
7 synovitis 11.5
8 noonan syndrome 4 11.4
9 tenosynovial giant cell tumor 10.7
10 arthritis 10.5
11 synovial chondromatosis 10.5
12 popliteal cyst 10.4
13 sarcoma 10.3
14 malignant giant cell tumor 10.3
15 hemarthrosis 10.3
16 neuropathy 10.3
17 tenosynovitis 10.3
18 carpal tunnel syndrome 10.2
19 mononeuropathy of the median nerve, mild 10.2
20 osteoarthritis 10.2
21 melanoma 10.2
22 synovium neoplasm 10.2
23 pseudo-turner syndrome 10.2
24 pulmonary valve stenosis 10.2 PTPN11 SOS1
25 pulmonary valve disease 10.2 PTPN11 SOS1
26 costello syndrome 10.2 PTPN11 SOS1
27 pulmonic stenosis 10.1 PTPN11 SOS1
28 cardiofaciocutaneous syndrome 1 10.1 PTPN11 SOS1
29 fibromatosis 10.1 SOS1 VIM
30 spondyloarthropathy 1 10.1
31 systemic lupus erythematosus 10.1
32 chediak-higashi syndrome 10.1
33 sarcoma, synovial 10.1
34 xanthomatosis 10.1
35 hemangioma 10.1
36 lymphoma 10.1
37 frozen shoulder 10.1
38 squamous cell carcinoma 10.1
39 chondroblastoma 10.1
40 nodular tenosynovitis 10.1
41 bursitis 10.1
42 mammary paget's disease 10.1
43 peroneal neuropathy 10.1
44 ulnar neuropathy 10.1
45 paget's disease of bone 10.1
46 paraplegia 10.1
47 epithelioid sarcoma 10.1
48 spondylitis 10.1
49 synovial angioma 10.1
50 lupus erythematosus 10.1

Graphical network of the top 20 diseases related to Villonodular Synovitis:



Diseases related to Villonodular Synovitis

Symptoms & Phenotypes for Villonodular Synovitis

UMLS symptoms related to Villonodular Synovitis:


arthralgia, pain, other symptoms referable to joint, stiffness of joint, not elsewhere classified in icd10cm

GenomeRNAi Phenotypes related to Villonodular Synovitis according to GeneCards Suite gene sharing:

27 (show all 13)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 9.44 VIM
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-142 9.44 TNFSF11
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.44 TNFSF11
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.44 SOS1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.44 SOS1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-175 9.44 TNFSF11
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.44 TNFSF11
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-203 9.44 SOS1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-212 9.44 VIM
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.44 SOS1
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.44 SOS1 TNFSF11 VIM
12 Decreased cell migration GR00055-A-1 9.33 ACP5 SOS1 VIM
13 Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance GR00210-A 9.13 ACP5 PTPN11 VIM

MGI Mouse Phenotypes related to Villonodular Synovitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.65 MMP9 PTPN11 SOS1 TNFSF11 VIM
2 muscle MP:0005369 9.55 MMP9 PTPN11 SOS1 TNFSF11 VIM
3 respiratory system MP:0005388 9.26 MMP9 PTPN11 TNFSF11 VIM
4 vision/eye MP:0005391 9.02 MMP9 PTPN11 SOS1 TNFSF11 VIM

Drugs & Therapeutics for Villonodular Synovitis

Drugs for Villonodular Synovitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sargramostim Approved, Investigational Phase 3 123774-72-1, 83869-56-1
2 Grapefruit Seed Extract Phase 2
3 Immunoglobulins Phase 1, Phase 2
4 Antibodies Phase 1, Phase 2
5
Paclitaxel Approved, Vet_approved Phase 1 33069-62-4 36314
6
Midazolam Approved, Illicit Phase 1 59467-70-8 4192
7
Tolbutamide Approved, Investigational Phase 1 64-77-7 5505
8 Albumin-Bound Paclitaxel Phase 1
9 Antimitotic Agents Phase 1
10 Antineoplastic Agents, Phytogenic Phase 1
11 Central Nervous System Depressants Phase 1
12 Hypoglycemic Agents Phase 1
13 Psychotropic Drugs Phase 1
14 Neurotransmitter Agents Phase 1
15 Anesthetics Phase 1
16 Anesthetics, Intravenous Phase 1
17 Anesthetics, General Phase 1
18 GABA Agents Phase 1
19 Hypnotics and Sedatives Phase 1
20 Tranquilizing Agents Phase 1
21 Anti-Anxiety Agents Phase 1
22 Adjuvants, Anesthesia Phase 1
23 GABA Modulators Phase 1

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Phase 3 Study of Pexidartinib for Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCT-TS) Active, not recruiting NCT02371369 Phase 3 Pexidartinib;Placebo
2 Study of Nilotinib Efficacy in Pigmented Villo-Nodular Synovitis/ Tenosynovial Giant Cell Tumour (PVNS/TGCT) Completed NCT01261429 Phase 2 Tasigna
3 MCS110 in Patients With Pigmented Villonodular Synovitis (PVNS) Completed NCT01643850 Phase 2 MCS110;Placebo;MCS110;Placebo
4 Nilotinib in Patients With Relapsed or Metastatic Pigmented Villonodular Synovitis/Tenosynovial Giant Cell Tumor/Diffuse-Type Giant Cell Tumor Active, not recruiting NCT01207492 Phase 2 nilotinib
5 Study of Cabiralizumab in Patients With Pigmented Villonodular Synovitis / Diffuse Type Tenosynovial Giant Cell Tumor Active, not recruiting NCT02471716 Phase 1, Phase 2
6 A Study of RO5509554 as Monotherapy and in Combination With Paclitaxel in Participants With Advanced Solid Tumors Completed NCT01494688 Phase 1 Paclitaxel;RO5509554
7 Effect of Pexidartinib on the Way the Body Processes CYP3A4 and CYP2C9 Substrates (Pharmacokinetics) Active, not recruiting NCT03291288 Phase 1 Tolbutamide;Midazolam;Pexidartinib
8 A Study of PLX73086 in Advanced Solid Tumors and Locally Advanced or Refractory Tenosynovial Giant Cell Tumor Terminated NCT02673736 Phase 1 PLX73086
9 Phase 1 Study of PLX7486 as Single Agent in Patients With Advanced Solid Tumors Terminated NCT01804530 Phase 1 PLX7486 TsOH
10 Evaluation of the Effectiveness of Surgical Treatment of Villo-nodular Synovitis of the Hip in Children Recruiting NCT03507933
11 Tenosynovial Giant Cell Tumors (TGCT) Observational Platform Project Recruiting NCT02948088

Search NIH Clinical Center for Villonodular Synovitis

Genetic Tests for Villonodular Synovitis

Anatomical Context for Villonodular Synovitis

MalaCards organs/tissues related to Villonodular Synovitis:

42
Bone, Testes, Neutrophil

Publications for Villonodular Synovitis

Articles related to Villonodular Synovitis:

(show top 50) (show all 769)
# Title Authors Year
1
Pigmented Villonodular Synovitis: Novel Role of Dual-Energy CT. ( 30614893 )
2019
2
Atypical Presentation of Pigmented Villonodular Synovitis: A Case Report. ( 30787857 )
2019
3
Osteochondral Lesion in Diffuse Pigmented Villonodular Synovitis of the Knee. ( 30871295 )
2019
4
Recurrent pigmented villonodular synovitis of the temporomandibular joint. ( 29904498 )
2018
5
Pigmented villonodular synovitis managed by total synovectomy and cementless total hip arthroplasty. ( 29700612 )
2018
6
Diffuse Pigmented Villonodular Synovitis Around the Ankle. ( 29634303 )
2018
7
Arthroscopic Management of Pigmented Villonodular Synovitis of the Hip in Children and Adolescents. ( 29594178 )
2018
8
Pigmented Villonodular Synovitis: A Close Mimic of Metastasis on<sup>18</sup>F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography. ( 29430127 )
2018
9
Nilotinib in locally advanced pigmented villonodular synovitis: challenges of a new targeted therapy. ( 29571947 )
2018
10
Distinct extra-articular invasion patterns of diffuse pigmented villonodular synovitis/tenosynovial giant cell tumor in the knee joints. ( 29637236 )
2018
11
Pigmented Villonodular Synovitis of the Knee: An Underappreciated Source of Pain in Children and Adolescents. ( 29917011 )
2018
12
Necessity of adjuvant postoperative radiotherapy for diffuse pigmented villonodular synovitis of the knee: A case report and literature review. ( 29504995 )
2018
13
Pigmented villonodular synovitis in pediatric population: review of literature and a case report. ( 29343257 )
2018
14
Arthroscopic Treatment of Diffuse Pigmented Villonodular Synovitis of the Knee: Complete Synovectomy and Septum Removal-Midterm Results. ( 29727868 )
2018
15
Nilotinib in locally advanced pigmented villonodular synovitis: a multicentre, open-label, single-arm, phase 2 trial. ( 29571946 )
2018
16
Computed Tomography Findings of Pigmented Villonodular Synovitis in a Dog. ( 29864767 )
2018
17
Lowering the recurrence rate in pigmented villonodular synovitis: A series of 120 resections. ( 29788491 )
2018
18
Concomitant Spondyloarthritis and Tenosynovial Giant Cell Tumor in Pigmented Villonodular Synovitis Challenging Cases. ( 30601200 )
2018
19
An unusual case of pigmented villonodular synovitis after total knee arthroplasty presenting with recurrent hemarthrosis. ( 30560170 )
2018
20
Localized Pigmented Villonodular Synovitis of the Posterior Knee Compartment with Popliteal Vessel Compression: A Case Report of Arthroscopic Resection Using Only Anterior Knee Portals. ( 30034899 )
2018
21
BILATERAL LOCALIZED PIGMENTED VILLONODULAR SYNOVITIS OF THE KNEE: CASE REPORT AND REVIEW. ( 30038543 )
2018
22
Diffuse Pigmented Villonodular Synovitis of the Subtalar Joint. ( 30039025 )
2018
23
A Rare Incidence of Pigmented Villonodular Synovitis of the Ankle in an Adolescent. ( 30146337 )
2018
24
Modified Lemaire extra-articular stabilisation of the knee for the treatment of anterolateral instability combined with diffuse pigmented villonodular synovitis: a case report. ( 30205827 )
2018
25
The predictive value of preoperative neutrophil-lymphocyte ratio (NLR) on the recurrence of the local pigmented villonodular synovitis of the knee joint. ( 30227838 )
2018
26
Complications After Total Knee Arthroplasty in Patients With Pigmented Villonodular Synovitis. ( 30266323 )
2018
27
Pigmented villonodular synovitis does not influence the outcome following cementless total hip arthroplasty using ceramic-on-ceramic articulation: a case-control study with middle-term follow-up. ( 30458820 )
2018
28
Pigmented villonodular synovitis occurring in the temporomandibular joint. ( 30497770 )
2018
29
The effects of radiosynoviorthesis in pigmented villonodular synovitis of the knee. ( 30539286 )
2018
30
Multifocal Pigmented Villonodular Synovitis in the Noonan Syndrome. ( 30631623 )
2018
31
Simultaneous pigmented villonodular synovitis and synovial chondromatosis of the hip: case report. ( 30647936 )
2018
32
Pigmented villonodular synovitis. ( 30745604 )
2018
33
Villonodular Synovitis of the Subtalar Joint: A Case Report. ( 30740375 )
2018
34
Localized pigmented villonodular synovitis of the ankle: Expect the unexpected. ( 28159047 )
2017
35
Open and Arthroscopic with Mini-Open Surgical Hip Approaches for Treatment of Pigmented Villonodular Synovitis and Concomitant Hip Pathology. ( 28326214 )
2017
36
Surgical treatment for diffused-type giant cell tumor (pigmented villonodular synovitis) about the ankle joint. ( 29137617 )
2017
37
Multifocal pigmented villonodular synovitis coexisting in both the knee joint and the patella: a case report and literature review. ( 28683727 )
2017
38
Localized pigmented villonodular synovitis of posterior compartment of the knee. ( 28847242 )
2017
39
Arthroscopic treatment of intra-artricularly localised pigmented villonodular synovitis of the ankle: 4 cases with long-term follow-up. ( 29202997 )
2017
40
Localized and diffuse forms of tenosynovial giant cell tumor (formerly giant cell tumor of the tendon sheath and pigmented villonodular synovitis). ( 28057477 )
2017
41
PIGMENTED VILLONODULAR SYNOVITIS IN A RETICULATED GIRAFFE (GIRAFFA CAMELOPARDALIS). ( 28749260 )
2017
42
Diffuse Pigmented Villonodular Synovitis as a Rare Cause of Graft Failure Following Anterior Cruciate Ligament Reconstruction. ( 28776631 )
2017
43
An unusual case of diffuse pigmented villonodular synovitis of the shoulder: A multidisciplinary approach with arthroscopic synovectomy and adjuvant radiotherapy. ( 28638690 )
2017
44
Long-Term Outcome of Hip Arthroplasty in the Setting of Pigmented Villonodular Synovitis. ( 29352684 )
2017
45
A rare case of localised pigmented villonodular synovitis in the knee of a 24-year-old female soccer player: diagnosis, management and summary of tenosynovial giant cell tumours. ( 28978573 )
2017
46
Long-term outcome of knee arthroplasty in the setting of pigmented villonodular synovitis. ( 28552192 )
2017
47
Total knee replacement in patients with diffuse villonodular synovitis. ( 29062829 )
2017
48
Long-term outcome of pigmented villonodular synovitis of the hip after joint preserving therapy. ( 29282525 )
2017
49
Systematic Arthroscopic Treatment of Diffuse Pigmented Villonodular Synovitis in the Knee. ( 29354472 )
2017
50
Results and recurrence of pigmented villonodular synovitis of the ankle: does diffuse PVNS with extra-articular extension tend to recur more often? ( 28389877 )
2017

Variations for Villonodular Synovitis

Expression for Villonodular Synovitis

Search GEO for disease gene expression data for Villonodular Synovitis.

Pathways for Villonodular Synovitis

Pathways related to Villonodular Synovitis according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.54 MMP9 PTPN11 SOS1
2
Show member pathways
12.46 MMP9 PTPN11 SOS1 TNFSF11 VIM
3 12.18 MMP9 SOS1 VIM
4
Show member pathways
12.14 PTPN11 SOS1 TNFSF11
5
Show member pathways
12.04 PTPN11 SOS1 VIM
6
Show member pathways
11.75 PTPN11 SOS1 TNFSF11
7 11.74 MMP9 PTPN11 SOS1
8
Show member pathways
11.61 PTPN11 SOS1
9
Show member pathways
11.58 PTPN11 SOS1
10 11.57 ACP5 TNFSF11
11 11.48 MMP9 PTPN11
12
Show member pathways
11.42 PTPN11 SOS1
13
Show member pathways
11.37 PTPN11 SOS1
14 11.31 PTPN11 SOS1
15 11.27 PTPN11 SOS1
16 11.2 PTPN11 SOS1
17 11.18 PTPN11 SOS1
18 11.12 PTPN11 SOS1
19 11.01 PTPN11 SOS1
20
Show member pathways
10.95 PTPN11 SOS1
21
Show member pathways
10.93 PTPN11 SOS1
22 10.88 PTPN11 SOS1
23 10.82 MMP9 SOS1
24 10.77 PTPN11 SOS1
25 10.47 MMP9 PTPN11 SOS1
26 10.36 ACP5 TNFSF11

GO Terms for Villonodular Synovitis

Biological processes related to Villonodular Synovitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 multicellular organism growth GO:0035264 9.48 PTPN11 SOS1
2 ephrin receptor signaling pathway GO:0048013 9.46 MMP9 PTPN11
3 epidermal growth factor receptor signaling pathway GO:0007173 9.43 PTPN11 SOS1
4 leukocyte migration GO:0050900 9.43 MMP9 PTPN11 SOS1
5 bone resorption GO:0045453 9.4 ACP5 TNFSF11
6 positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 9.37 MMP9 SOS1
7 neurotrophin TRK receptor signaling pathway GO:0048011 9.32 PTPN11 SOS1
8 Bergmann glial cell differentiation GO:0060020 9.16 PTPN11 VIM
9 ossification GO:0001503 9.13 ACP5 MMP9 TNFSF11
10 cytokine-mediated signaling pathway GO:0019221 9.02 MMP9 PTPN11 SOS1 TNFSF11 VIM

Sources for Villonodular Synovitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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