MCID: VLL001
MIFTS: 34

Villous Adenocarcinoma

Categories: Cancer diseases

Aliases & Classifications for Villous Adenocarcinoma

MalaCards integrated aliases for Villous Adenocarcinoma:

Name: Villous Adenocarcinoma 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:4917
NCIt 51 C4142
SNOMED-CT 69 28558000
UMLS 74 C0334306

Summaries for Villous Adenocarcinoma

Disease Ontology : 12 An adenocarcinoma that derives from epithelial cells originating in glandular tissue, with villous architecture.

MalaCards based summary : Villous Adenocarcinoma is related to adenocarcinoma and colon adenocarcinoma. An important gene associated with Villous Adenocarcinoma is ITGB5 (Integrin Subunit Beta 5), and among its related pathways/superpathways are Apoptotic Pathways in Synovial Fibroblasts and GPCR Pathway. Affiliated tissues include colon, skin and tongue, and related phenotypes are Decreased cell migration and Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance

Related Diseases for Villous Adenocarcinoma

Diseases related to Villous Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Related Disease Score Top Affiliating Genes
1 adenocarcinoma 10.4
2 colon adenocarcinoma 10.1
3 supratentorial cancer 10.0 EGFR MMP2
4 cerebrum cancer 10.0 EGFR MMP2
5 extracranial arteriovenous malformation 9.9 MMP2 MMP9
6 focal myositis 9.9 MMP2 MMP9
7 spastic entropion 9.9 MMP2 MMP9
8 lentigo maligna melanoma 9.9 MMP2 MMP9
9 psammomatous meningioma 9.9 MMP2 MMP9
10 acute transverse myelitis 9.9 MMP2 MMP9
11 transverse myelitis 9.9 MMP2 MMP9
12 senile ectropion 9.9 MMP2 MMP9
13 internal hemorrhoid 9.9 MMP2 MMP9
14 bile duct cancer 9.9 EGFR MMP2
15 ischemic colitis 9.9 MMP2 MMP9
16 light chain deposition disease 9.9 MMP2 MMP9
17 conjunctival nevus 9.9 MMP2 MMP9
18 parotitis 9.9 MMP2 MMP9
19 klatskin's tumor 9.9 MMP2 MMP9
20 corneal ulcer 9.9 MMP2 MMP9
21 nasal cavity squamous cell carcinoma 9.9 MMP2 MMP9
22 odontogenic myxoma 9.9 MMP2 MMP9
23 differentiated thyroid carcinoma 9.9 EGFR FN1
24 intussusception 9.9
25 polyposis, skin pigmentation, alopecia, and fingernail changes 9.9
26 villous adenoma 9.9
27 adenoma 9.9
28 newcastle disease 9.9 MMP2 MMP9
29 hypertensive heart disease 9.9 MMP2 MMP9
30 pharynx cancer 9.9 EGFR MMP9
31 pneumothorax 9.9 MMP2 MMP9
32 aortic aneurysm, familial abdominal, 1 9.9 MMP2 MMP9
33 adenomyosis 9.8 MMP2 MMP9
34 skin melanoma 9.8 MMP2 MMP9
35 aortic disease 9.8 MMP2 MMP9
36 varicose veins 9.8 MMP2 MMP9
37 tongue cancer 9.8 MMP2 MMP9
38 stomach disease 9.8 EGFR MMP9
39 inguinal hernia 9.7 ITGA3 MMP2 MMP9
40 periodontitis 9.7 MMP2 MMP9
41 interstitial lung disease 9.7 EGFR ITGA3 MMP9
42 lung disease 9.7 EGFR ITGA3 MMP9
43 laryngeal disease 9.6 EGFR MMP2 MMP9
44 grade iii astrocytoma 9.6 EGFR MMP2 MMP9
45 oral cancer 9.6 EGFR MMP2 MMP9
46 female reproductive system disease 9.6 EGFR MMP2 MMP9
47 reproductive system disease 9.6 EGFR MMP2 MMP9
48 respiratory system cancer 9.6 EGFR MMP2 MMP9
49 gliosarcoma 9.6 EGFR MMP2 MMP9
50 gastrointestinal system cancer 9.6 EGFR MMP2 MMP9

Graphical network of the top 20 diseases related to Villous Adenocarcinoma:



Diseases related to Villous Adenocarcinoma

Symptoms & Phenotypes for Villous Adenocarcinoma

GenomeRNAi Phenotypes related to Villous Adenocarcinoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased cell migration GR00055-A-1 9.13 EGFR ITGA3 ITGB5
2 Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance GR00210-A 8.8 EGFR ITGA3 ITGB5

MGI Mouse Phenotypes related to Villous Adenocarcinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.91 EGFR FN1 ITGA3 ITGB5 MMP2 MMP9
2 immune system MP:0005387 9.88 EGFR FN1 ITGA3 ITGB5 MMP2 MMP9
3 integument MP:0010771 9.77 EGFR FN1 ITGA3 ITGB5 MMP9
4 neoplasm MP:0002006 9.63 EGFR FN1 ITGA3 ITGB5 MMP2 MMP9
5 limbs/digits/tail MP:0005371 9.62 EGFR FN1 ITGA3 MMP9
6 muscle MP:0005369 9.56 EGFR FN1 MMP2 MMP9
7 respiratory system MP:0005388 9.26 EGFR ITGA3 MMP2 MMP9
8 vision/eye MP:0005391 9.02 EGFR ITGA3 ITGB5 MMP2 MMP9

Drugs & Therapeutics for Villous Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Villous Adenocarcinoma

Genetic Tests for Villous Adenocarcinoma

Anatomical Context for Villous Adenocarcinoma

MalaCards organs/tissues related to Villous Adenocarcinoma:

42
Colon, Skin, Tongue, Thyroid

Publications for Villous Adenocarcinoma

Articles related to Villous Adenocarcinoma:

(show all 12)
# Title Authors Year
1
Complete Endoscopic Submucosal Dissection of a Giant Rectal Villous Adenocarcinoma with Electrolyte Depletion Syndrome. ( 26078730 )
2015
2
A case of Cronkhite-Canada syndrome complicated by McKittrick-Wheelock syndrome associated with advanced villous adenocarcinoma. ( 20887986 )
2011
3
Villous adenocarcinoma of the colon. ( 15897758 )
2005
4
Villous adenocarcinoma of the colon and rectum: a clinicopathologic study of 36 cases. ( 15489649 )
2004
5
Prolapse of the common bile duct with small ampullary villous adenocarcinoma into third part of the duodenum. ( 12876062 )
2003
6
Villous adenocarcinoma of the duodenum invading the ampulla of Vater case report and review of literature. ( 9184865 )
1996
7
Laparoscopic management of appendiceal intussusception associated with villous adenocarcinoma. ( 7833525 )
1994
8
Villous adenocarcinoma arising in the bypassed duodenum 18 years after a Billroth II subtotal gastrectomy: report of a case and review of the literature. ( 3976635 )
1985
9
Villous adenocarcinoma of the male urethra. ( 6644903 )
1983
10
Radiology case of the month. Villous adenoma or villous adenocarcinoma. ( 7230792 )
1981
11
Villous adenocarcinoma of the rectum with severe electrolyte derangement. ( 5413333 )
1970
12
Villous adenocarcinoma of the colon with pronounced electrolyte disturbance. ( 13911186 )
1962

Variations for Villous Adenocarcinoma

Expression for Villous Adenocarcinoma

Search GEO for disease gene expression data for Villous Adenocarcinoma.

Pathways for Villous Adenocarcinoma

Pathways related to Villous Adenocarcinoma according to GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.59 EGFR ITGA3 ITGB5 MMP2 MMP9
2
Show member pathways
13.45 EGFR ITGA3 ITGB5 MMP2 MMP9
3
Show member pathways
13.11 EGFR FN1 MMP2 MMP9
4
Show member pathways
12.94 EGFR FN1 ITGA3 ITGB5 MMP2 MMP9
5
Show member pathways
12.83 EGFR FN1 ITGA3 ITGB5
6
Show member pathways
12.76 EGFR FN1 ITGA3 ITGB5
7
Show member pathways
12.67 EGFR FN1 ITGA3 ITGB5
8
Show member pathways
12.48 EGFR MMP2 MMP9
9
Show member pathways
12.46 EGFR FN1 MMP2
10
Show member pathways
12.41 FN1 MMP2 MMP9
11 12.39 EGFR FN1 ITGA3 ITGB5
12 12.38 EGFR FN1 ITGA3 MMP2 MMP9
13
Show member pathways
12.34 EGFR MMP2 MMP9
14
Show member pathways
12.33 EGFR FN1 ITGA3 MMP2
15
Show member pathways
12.23 EGFR ITGA3 ITGB5
16
Show member pathways
12.21 FN1 ITGA3 ITGB5 MMP2 MMP9
17
Show member pathways
12.18 EGFR ITGA3 ITGB5
18
Show member pathways
12.05 EGFR FN1 ITGB5
19
Show member pathways
12.01 EGFR ITGA3 ITGB5
20 12 EGFR MMP2 MMP9
21
Show member pathways
11.97 FN1 ITGA3 ITGB5
22 11.95 EGFR ITGA3 ITGB5
23
Show member pathways
11.87 FN1 ITGA3 ITGB5 MMP2 MMP9
24
Show member pathways
11.86 FN1 MMP2 MMP9
25 11.84 ITGB5 MMP2 MMP9
26 11.79 FN1 MMP2 MMP9
27 11.67 ITGB5 MMP2 MMP9
28 11.64 FN1 ITGA3 ITGB5
29 11.61 MMP2 MMP9
30 11.59 ITGA3 MMP9
31 11.55 EGFR MMP2 MMP9
32 11.54 EGFR FN1
33 11.54 EGFR ITGA3 ITGB5
34 11.5 MMP2 MMP9
35
Show member pathways
11.5 MMP2 MMP9
36 11.47 EGFR MMP2 MMP9
37 11.45 EGFR MMP2 MMP9
38
Show member pathways
11.43 EGFR MMP2 MMP9
39 11.4 EGFR MMP2
40
Show member pathways
11.34 MMP2 MMP9
41 11.32 FN1 ITGB5
42 11.32 EGFR FN1 ITGB5 MMP2 MMP9
43 11.29 FN1 MMP2 MMP9
44 11.27 ITGA3 MMP9
45 11.21 EGFR ITGA3 ITGB5
46 11.2 MMP2 MMP9
47 11.18 FN1 MMP2
48 11.18 FN1 ITGA3 ITGB5
49 11.17 MMP2 MMP9
50 11.15 FN1 MMP9

GO Terms for Villous Adenocarcinoma

Cellular components related to Villous Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 focal adhesion GO:0005925 9.5 EGFR ITGA3 ITGB5
2 extracellular matrix GO:0031012 9.43 FN1 MMP2 MMP9
3 collagen-containing extracellular matrix GO:0062023 9.33 FN1 MMP2 MMP9
4 integrin complex GO:0008305 8.96 ITGA3 ITGB5
5 receptor complex GO:0043235 8.8 EGFR ITGA3 ITGB5

Biological processes related to Villous Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.58 FN1 MMP2 MMP9
2 viral entry into host cell GO:0046718 9.57 EGFR ITGB5
3 ephrin receptor signaling pathway GO:0048013 9.56 MMP2 MMP9
4 extracellular matrix disassembly GO:0022617 9.55 MMP2 MMP9
5 cellular response to amino acid stimulus GO:0071230 9.54 EGFR MMP2
6 positive regulation of protein localization to plasma membrane GO:1903078 9.52 EGFR ITGA3
7 positive regulation of fibroblast proliferation GO:0048146 9.51 EGFR FN1
8 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.49 MMP2 MMP9
9 embryo implantation GO:0007566 9.48 MMP2 MMP9
10 cellular response to cadmium ion GO:0071276 9.46 EGFR MMP9
11 collagen catabolic process GO:0030574 9.43 MMP2 MMP9
12 leukocyte migration GO:0050900 9.43 FN1 ITGA3 MMP9
13 cellular response to reactive oxygen species GO:0034614 9.37 EGFR MMP9
14 cell-matrix adhesion GO:0007160 9.33 FN1 ITGA3 ITGB5
15 regulation of ERK1 and ERK2 cascade GO:0070372 9.32 EGFR FN1
16 extracellular matrix organization GO:0030198 9.26 FN1 ITGA3 ITGB5 MMP9
17 endodermal cell differentiation GO:0035987 8.92 FN1 ITGB5 MMP2 MMP9

Molecular functions related to Villous Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 virus receptor activity GO:0001618 9.16 EGFR ITGB5
2 collagen binding GO:0005518 9.13 FN1 ITGA3 MMP9
3 integrin binding GO:0005178 8.92 EGFR FN1 ITGA3 ITGB5

Sources for Villous Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....