MCID: VLL001
MIFTS: 25

Villous Adenocarcinoma

Categories: Cancer diseases

Aliases & Classifications for Villous Adenocarcinoma

MalaCards integrated aliases for Villous Adenocarcinoma:

Name: Villous Adenocarcinoma 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:4917
NCIt 50 C4142
SNOMED-CT 67 28558000
UMLS 70 C0334306

Summaries for Villous Adenocarcinoma

Disease Ontology : 12 An adenocarcinoma that derives from epithelial cells originating in glandular tissue, with villous architecture.

MalaCards based summary : Villous Adenocarcinoma is related to adenocarcinoma and villous adenoma. An important gene associated with Villous Adenocarcinoma is ITGB5 (Integrin Subunit Beta 5), and among its related pathways/superpathways are PI3K-Akt signaling pathway and NFAT and Cardiac Hypertrophy. Affiliated tissues include colon, skin and appendix, and related phenotypes are cardiovascular system and neoplasm

Related Diseases for Villous Adenocarcinoma

Graphical network of the top 20 diseases related to Villous Adenocarcinoma:



Diseases related to Villous Adenocarcinoma

Symptoms & Phenotypes for Villous Adenocarcinoma

MGI Mouse Phenotypes related to Villous Adenocarcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.35 ACP1 GNAS ITGA3 ITGB5 MT-ND6
2 neoplasm MP:0002006 8.92 GNAS ITGA3 ITGB5 MT-ND6

Drugs & Therapeutics for Villous Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Villous Adenocarcinoma

Genetic Tests for Villous Adenocarcinoma

Anatomical Context for Villous Adenocarcinoma

MalaCards organs/tissues related to Villous Adenocarcinoma:

40
Colon, Skin, Appendix

Publications for Villous Adenocarcinoma

Articles related to Villous Adenocarcinoma:

(show all 20)
# Title Authors PMID Year
1
[Prevalence and attribution of high-risk HPV in different histological types of cervical cancer]. 61
31154709 2019
2
Complete Endoscopic Submucosal Dissection of a Giant Rectal Villous Adenocarcinoma with Electrolyte Depletion Syndrome. 61
26078730 2015
3
Expression profiling using a cDNA array and immunohistochemistry for the extracellular matrix genes FN-1, ITGA-3, ITGB-5, MMP-2, and MMP-9 in colorectal carcinoma progression and dissemination. 61
24737953 2014
4
A case of Cronkhite-Canada syndrome complicated by McKittrick-Wheelock syndrome associated with advanced villous adenocarcinoma. 61
20887986 2011
5
Undiagnosed rectal tumour--a rare cause of obstructed labour in the second stage. 61
22767473 2010
6
Villous adenocarcinoma of the colon. 61
15897758 2005
7
Villous adenocarcinoma of the colon and rectum: a clinicopathologic study of 36 cases. 61
15489649 2004
8
Prolapse of the common bile duct with small ampullary villous adenocarcinoma into third part of the duodenum. 61
12876062 2003
9
[Campylobacter fetus endocarditis manifested by a popliteal mycotic aneurysm]. 61
9768000 1998
10
Villous adenocarcinoma of the duodenum invading the ampulla of Vater case report and review of literature. 61
9184865 1996
11
Laparoscopic management of appendiceal intussusception associated with villous adenocarcinoma. 61
7833525 1994
12
DNA content and its relationship with pathology and prognosis of colorectal carcinoma. 61
1395845 1992
13
Adenocarcinoma of the gallbladder associated with congenital choledochal cyst and anomalous pancreaticobiliary ductal junction. Case report. 61
1683581 1991
14
[A case report of carcinoid of the rectum coexisting with adenocarcinoma in a single lesion]. 61
3346997 1988
15
Villous adenocarcinoma arising in the bypassed duodenum 18 years after a Billroth II subtotal gastrectomy: report of a case and review of the literature. 61
3976635 1985
16
Villous adenocarcinoma of the male urethra. 61
6644903 1983
17
Radiology case of the month. Villous adenoma or villous adenocarcinoma. 61
7230792 1981
18
Villous adenocarcinoma of the rectum with severe electrolyte derangement. 61
5413333 1970
19
[Fluid and electrolyte disturbances caused by papillomatous(villous) adenocarcinoma in the rectosigmoid]. 61
6042540 1967
20
Villous adenocarcinoma of the colon with pronounced electrolyte disturbance. 61
13911186 1962

Variations for Villous Adenocarcinoma

Expression for Villous Adenocarcinoma

Search GEO for disease gene expression data for Villous Adenocarcinoma.

Pathways for Villous Adenocarcinoma

Pathways related to Villous Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.49 ITGB5 ITGA3 GNAS
2
Show member pathways
12.37 ITGB5 ITGA3 GNAS
3
Show member pathways
12.33 ITGB5 ITGA3 GNAS
4
Show member pathways
12.26 MT-ND6 MT-ATP8 GNAS
5
Show member pathways
12.13 ITGB5 ITGA3 GNAS
6
Show member pathways
11.65 ITGB5 ITGA3
7 11.33 ITGB5 ITGA3
8
Show member pathways
11.07 ITGB5 ITGA3 GNAS
9 10.82 ITGB5 ITGA3 GNAS
10 10.76 ITGB5 ITGA3
11 10.51 ITGB5 ITGA3 GNAS

GO Terms for Villous Adenocarcinoma

Cellular components related to Villous Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 9.43 MT-ND6 MT-ATP8 ITGB5 ITGA3 GNAS ACP1
2 integrin complex GO:0008305 8.62 ITGB5 ITGA3

Biological processes related to Villous Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integrin-mediated signaling pathway GO:0007229 9.16 ITGB5 ITGA3
2 cell-matrix adhesion GO:0007160 8.96 ITGB5 ITGA3
3 skin development GO:0043588 8.62 ITGA3 GNAS

Molecular functions related to Villous Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integrin binding GO:0005178 8.62 ITGB5 ITGA3

Sources for Villous Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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