MCID: VLL001
MIFTS: 33

Villous Adenocarcinoma

Categories: Cancer diseases

Aliases & Classifications for Villous Adenocarcinoma

MalaCards integrated aliases for Villous Adenocarcinoma:

Name: Villous Adenocarcinoma 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:4917
NCIt 50 C4142
SNOMED-CT 68 28558000
UMLS 73 C0334306

Summaries for Villous Adenocarcinoma

Disease Ontology : 12 An adenocarcinoma that derives from epithelial cells originating in glandular tissue, with villous architecture.

MalaCards based summary : Villous Adenocarcinoma is related to adenocarcinoma and malignant ovarian surface epithelial-stromal neoplasm. An important gene associated with Villous Adenocarcinoma is ITGB5 (Integrin Subunit Beta 5), and among its related pathways/superpathways are Apoptotic Pathways in Synovial Fibroblasts and GPCR Pathway. Affiliated tissues include colon, and related phenotypes are Decreased cell migration and Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance

Related Diseases for Villous Adenocarcinoma

Diseases related to Villous Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Related Disease Score Top Affiliating Genes
1 adenocarcinoma 10.3
2 malignant ovarian surface epithelial-stromal neoplasm 10.0 EGFR MMP2
3 ovary epithelial cancer 9.9 EGFR MMP2
4 differentiated thyroid carcinoma 9.9 EGFR FN1
5 intussusception 9.8
6 polyposis, skin pigmentation, alopecia, and fingernail changes 9.8
7 villous adenoma 9.8
8 adenoma 9.8
9 extracranial arteriovenous malformation 9.8 MMP2 MMP9
10 focal myositis 9.7 MMP2 MMP9
11 spastic entropion 9.7 MMP2 MMP9
12 lentigo maligna melanoma 9.7 MMP2 MMP9
13 psammomatous meningioma 9.7 MMP2 MMP9
14 acute transverse myelitis 9.7 MMP2 MMP9
15 senile ectropion 9.7 MMP2 MMP9
16 internal hemorrhoid 9.7 MMP2 MMP9
17 ischemic colitis 9.7 MMP2 MMP9
18 parotitis 9.7 MMP2 MMP9
19 light chain deposition disease 9.7 MMP2 MMP9
20 conjunctival nevus 9.7 MMP2 MMP9
21 klatskin's tumor 9.7 MMP2 MMP9
22 microcystic meningioma 9.7 MMP2 MMP9
23 adenomyosis 9.7 MMP2 MMP9
24 corneal ulcer 9.7 MMP2 MMP9
25 pharynx cancer 9.7 EGFR MMP9
26 nasal cavity squamous cell carcinoma 9.7 MMP2 MMP9
27 odontogenic myxoma 9.7 MMP2 MMP9
28 transverse myelitis 9.7 MMP2 MMP9
29 sorsby fundus dystrophy 9.6 MMP2 MMP9
30 lung giant cell carcinoma 9.6 MMP2 MMP9
31 hypertensive heart disease 9.6 MMP2 MMP9
32 aortic aneurysm, familial thoracic 1 9.6 MMP2 MMP9
33 tongue cancer 9.5 MMP2 MMP9
34 pneumothorax 9.5 MMP2 MMP9
35 aortic disease 9.5 MMP2 MMP9
36 varicose veins 9.5 MMP2 MMP9
37 aortic aneurysm, familial abdominal, 1 9.5 MMP2 MMP9
38 interstitial lung disease 9.3 EGFR ITGA3 MMP9
39 inguinal hernia 9.2 ITGA3 MMP2 MMP9
40 periodontitis 9.2 MMP2 MMP9
41 salivary gland cancer 9.2 EGFR MMP2 MMP9
42 grade iii astrocytoma 9.2 EGFR MMP2 MMP9
43 oral cancer 9.1 EGFR MMP2 MMP9
44 female reproductive organ cancer 9.1 EGFR MMP2 MMP9
45 respiratory system cancer 9.1 EGFR MMP2 MMP9
46 gliosarcoma 9.1 EGFR MMP2 MMP9
47 cell type cancer 9.1 EGFR MMP2 MMP9
48 gastrointestinal system cancer 9.1 EGFR MMP2 MMP9
49 adamantinoma of long bones 9.1 EGFR MMP2 MMP9
50 squamous cell carcinoma, head and neck 9.1 EGFR MMP2 MMP9

Graphical network of the top 20 diseases related to Villous Adenocarcinoma:



Diseases related to Villous Adenocarcinoma

Symptoms & Phenotypes for Villous Adenocarcinoma

GenomeRNAi Phenotypes related to Villous Adenocarcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased cell migration GR00055-A-1 9.13 EGFR ITGA3 ITGB5
2 Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance GR00210-A 8.8 EGFR ITGA3 ITGB5

MGI Mouse Phenotypes related to Villous Adenocarcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.91 MMP2 EGFR MMP9 FN1 ITGA3 ITGB5
2 immune system MP:0005387 9.88 ITGB5 MMP2 EGFR MMP9 FN1 ITGA3
3 integument MP:0010771 9.77 ITGB5 EGFR MMP9 FN1 ITGA3
4 neoplasm MP:0002006 9.63 MMP2 EGFR MMP9 FN1 ITGA3 ITGB5
5 limbs/digits/tail MP:0005371 9.62 EGFR MMP9 FN1 ITGA3
6 muscle MP:0005369 9.56 MMP2 EGFR MMP9 FN1
7 respiratory system MP:0005388 9.26 MMP2 EGFR MMP9 ITGA3
8 vision/eye MP:0005391 9.02 ITGB5 MMP2 EGFR MMP9 ITGA3

Drugs & Therapeutics for Villous Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Villous Adenocarcinoma

Genetic Tests for Villous Adenocarcinoma

Anatomical Context for Villous Adenocarcinoma

MalaCards organs/tissues related to Villous Adenocarcinoma:

41
Colon

Publications for Villous Adenocarcinoma

Articles related to Villous Adenocarcinoma:

(show all 12)
# Title Authors Year
1
Complete Endoscopic Submucosal Dissection of a Giant Rectal Villous Adenocarcinoma with Electrolyte Depletion Syndrome. ( 26078730 )
2015
2
A case of Cronkhite-Canada syndrome complicated by McKittrick-Wheelock syndrome associated with advanced villous adenocarcinoma. ( 20887986 )
2011
3
Villous adenocarcinoma of the colon. ( 15897758 )
2005
4
Villous adenocarcinoma of the colon and rectum: a clinicopathologic study of 36 cases. ( 15489649 )
2004
5
Prolapse of the common bile duct with small ampullary villous adenocarcinoma into third part of the duodenum. ( 12876062 )
2003
6
Villous adenocarcinoma of the duodenum invading the ampulla of Vater case report and review of literature. ( 9184865 )
1996
7
Laparoscopic management of appendiceal intussusception associated with villous adenocarcinoma. ( 7833525 )
1994
8
Villous adenocarcinoma arising in the bypassed duodenum 18 years after a Billroth II subtotal gastrectomy: report of a case and review of the literature. ( 3976635 )
1985
9
Villous adenocarcinoma of the male urethra. ( 6644903 )
1983
10
Radiology case of the month. Villous adenoma or villous adenocarcinoma. ( 7230792 )
1981
11
Villous adenocarcinoma of the rectum with severe electrolyte derangement. ( 5413333 )
1970
12
Villous adenocarcinoma of the colon with pronounced electrolyte disturbance. ( 13911186 )
1962

Variations for Villous Adenocarcinoma

Expression for Villous Adenocarcinoma

Search GEO for disease gene expression data for Villous Adenocarcinoma.

Pathways for Villous Adenocarcinoma

Pathways related to Villous Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 48)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.57 EGFR ITGA3 ITGB5 MMP2 MMP9
2
Show member pathways
13.43 EGFR ITGA3 ITGB5 MMP2 MMP9
3
Show member pathways
13.1 EGFR FN1 MMP2 MMP9
4
Show member pathways
12.94 EGFR FN1 ITGA3 ITGB5 MMP2 MMP9
5
Show member pathways
12.81 EGFR FN1 ITGA3 ITGB5
6
Show member pathways
12.73 EGFR FN1 ITGA3 ITGB5
7
Show member pathways
12.71 EGFR ITGA3 ITGB5
8
Show member pathways
12.65 EGFR FN1 ITGA3 ITGB5
9
Show member pathways
12.54 EGFR MMP2 MMP9
10
Show member pathways
12.44 EGFR FN1 MMP2
11
Show member pathways
12.39 FN1 MMP2 MMP9
12 12.38 EGFR FN1 ITGA3 MMP2 MMP9
13 12.37 EGFR FN1 ITGA3 ITGB5
14
Show member pathways
12.33 EGFR MMP2 MMP9
15
Show member pathways
12.33 EGFR FN1 ITGA3 MMP2
16
Show member pathways
12.21 EGFR ITGA3 ITGB5
17
Show member pathways
12.21 FN1 ITGA3 ITGB5 MMP2 MMP9
18
Show member pathways
12.03 EGFR FN1 ITGB5
19 11.98 EGFR MMP2 MMP9
20 11.95 EGFR ITGA3 ITGB5
21
Show member pathways
11.93 FN1 ITGA3 ITGB5
22
Show member pathways
11.9 FN1 ITGA3 ITGB5
23 11.82 ITGB5 MMP2 MMP9
24 11.78 FN1 MMP2 MMP9
25 11.66 ITGB5 MMP2 MMP9
26 11.63 FN1 ITGA3 ITGB5
27 11.6 MMP2 MMP9
28 11.58 ITGA3 MMP9
29 11.52 EGFR FN1
30 11.52 EGFR MMP2 MMP9
31 11.48 MMP2 MMP9
32
Show member pathways
11.48 MMP2 MMP9
33 11.45 EGFR MMP2 MMP9
34 11.42 EGFR MMP2 MMP9
35 11.38 EGFR MMP2
36
Show member pathways
11.32 MMP2 MMP9
37 11.32 EGFR FN1 ITGB5 MMP2 MMP9
38 11.3 FN1 ITGB5
39 11.26 FN1 MMP2 MMP9
40 11.25 ITGA3 MMP9
41 11.18 MMP2 MMP9
42 11.17 FN1 MMP2
43 11.15 MMP2 MMP9
44 11.15 FN1 ITGA3 ITGB5
45 11.13 FN1 MMP9
46 11.04 MMP2 MMP9
47 11.04 EGFR FN1 MMP2 MMP9
48 10.97 MMP2 MMP9

GO Terms for Villous Adenocarcinoma

Cellular components related to Villous Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 focal adhesion GO:0005925 9.43 EGFR ITGA3 ITGB5
2 integrin complex GO:0008305 9.16 ITGA3 ITGB5
3 extracellular matrix GO:0031012 9.13 FN1 MMP2 MMP9
4 receptor complex GO:0043235 8.8 EGFR ITGA3 ITGB5

Biological processes related to Villous Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.65 FN1 MMP2 MMP9
2 ephrin receptor signaling pathway GO:0048013 9.57 MMP2 MMP9
3 viral entry into host cell GO:0046718 9.56 EGFR ITGB5
4 collagen catabolic process GO:0030574 9.55 MMP2 MMP9
5 cellular response to amino acid stimulus GO:0071230 9.54 EGFR MMP2
6 positive regulation of fibroblast proliferation GO:0048146 9.52 EGFR FN1
7 positive regulation of protein localization to plasma membrane GO:1903078 9.51 EGFR ITGA3
8 leukocyte migration GO:0050900 9.5 FN1 ITGA3 MMP9
9 embryo implantation GO:0007566 9.49 MMP2 MMP9
10 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.46 MMP2 MMP9
11 cellular response to reactive oxygen species GO:0034614 9.43 EGFR MMP9
12 cell-matrix adhesion GO:0007160 9.43 FN1 ITGA3 ITGB5
13 cellular response to cadmium ion GO:0071276 9.4 EGFR MMP9
14 regulation of ERK1 and ERK2 cascade GO:0070372 9.37 EGFR FN1
15 extracellular matrix disassembly GO:0022617 9.33 FN1 MMP2 MMP9
16 extracellular matrix organization GO:0030198 9.26 FN1 ITGA3 ITGB5 MMP9
17 endodermal cell differentiation GO:0035987 8.92 FN1 ITGB5 MMP2 MMP9

Molecular functions related to Villous Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 virus receptor activity GO:0001618 9.16 EGFR ITGB5
2 integrin binding GO:0005178 9.13 EGFR FN1 ITGA3
3 collagen binding GO:0005518 8.8 FN1 ITGA3 MMP9

Sources for Villous Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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