MCID: VLL001
MIFTS: 33

Villous Adenocarcinoma

Categories: Cancer diseases

Aliases & Classifications for Villous Adenocarcinoma

MalaCards integrated aliases for Villous Adenocarcinoma:

Name: Villous Adenocarcinoma 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:4917
NCIt 50 C4142
SNOMED-CT 68 28558000
UMLS 73 C0334306

Summaries for Villous Adenocarcinoma

Disease Ontology : 12 An adenocarcinoma that derives from epithelial cells originating in glandular tissue, with villous architecture.

MalaCards based summary : Villous Adenocarcinoma is related to adenocarcinoma and extracranial arteriovenous malformation. An important gene associated with Villous Adenocarcinoma is ITGB5 (Integrin Subunit Beta 5), and among its related pathways/superpathways are Integrin Pathway and PI3K-Akt signaling pathway. Affiliated tissues include colon, lung and skin, and related phenotypes are Mildly decreased CFP-tsO45G cell surface transport and cardiovascular system

Related Diseases for Villous Adenocarcinoma

Diseases related to Villous Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
# Related Disease Score Top Affiliating Genes
1 adenocarcinoma 10.4
2 extracranial arteriovenous malformation 10.0 MMP2 MMP9
3 focal myositis 10.0 MMP2 MMP9
4 spastic entropion 10.0 MMP2 MMP9
5 lentigo maligna melanoma 9.9 MMP2 MMP9
6 psammomatous meningioma 9.9 MMP2 MMP9
7 acute transverse myelitis 9.9 MMP2 MMP9
8 transverse myelitis 9.9 MMP2 MMP9
9 senile ectropion 9.9 MMP2 MMP9
10 internal hemorrhoid 9.9 MMP2 MMP9
11 ischemic colitis 9.9 MMP2 MMP9
12 light chain deposition disease 9.9 MMP2 MMP9
13 conjunctival nevus 9.9 MMP2 MMP9
14 parotitis 9.9 MMP2 MMP9
15 klatskin's tumor 9.9 MMP2 MMP9
16 corneal ulcer 9.9 MMP2 MMP9
17 nasal cavity squamous cell carcinoma 9.9 MMP2 MMP9
18 odontogenic myxoma 9.9 MMP2 MMP9
19 laryngeal disease 9.9 MMP2 MMP9
20 hypertensive heart disease 9.9 MMP2 MMP9
21 interstitial lung disease 9.9 ITGA3 MMP9
22 aortic aneurysm, familial thoracic 1 9.9 MMP2 MMP9
23 pneumothorax 9.9 MMP2 MMP9
24 adenomyosis 9.9 MMP2 MMP9
25 grade iii astrocytoma 9.9 MMP2 MMP9
26 skin melanoma 9.9 MMP2 MMP9
27 aortic disease 9.9 MMP2 MMP9
28 varicose veins 9.9 MMP2 MMP9
29 tongue cancer 9.9 MMP2 MMP9
30 oral cancer 9.9 MMP2 MMP9
31 female reproductive system disease 9.9 MMP2 MMP9
32 reproductive system disease 9.9 MMP2 MMP9
33 aortic aneurysm, familial abdominal, 1 9.9 MMP2 MMP9
34 respiratory system cancer 9.9 MMP2 MMP9
35 intussusception 9.9
36 polyposis, skin pigmentation, alopecia, and fingernail changes 9.9
37 villous adenoma 9.9
38 adenoma 9.9
39 gliosarcoma 9.9 MMP2 MMP9
40 periodontitis 9.9 MMP2 MMP9
41 tongue squamous cell carcinoma 9.9 MMP2 MMP9
42 gastrointestinal system cancer 9.8 MMP2 MMP9
43 endocrine gland cancer 9.8 MMP2 MMP9
44 periodontal disease 9.8 MMP2 MMP9
45 inguinal hernia 9.8 ITGA3 MMP2 MMP9
46 breast adenocarcinoma 9.8 MMP2 MMP9
47 gastrointestinal system disease 9.7 MMP2 MMP9
48 lung cancer 9.5 FN1 ITGA3 MMP2 MMP9

Graphical network of the top 20 diseases related to Villous Adenocarcinoma:



Diseases related to Villous Adenocarcinoma

Symptoms & Phenotypes for Villous Adenocarcinoma

GenomeRNAi Phenotypes related to Villous Adenocarcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Mildly decreased CFP-tsO45G cell surface transport GR00360-A-1 9.02 FN1 ITGA3 ITGB5 MMP2 MMP9

MGI Mouse Phenotypes related to Villous Adenocarcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.72 FN1 ITGA3 ITGB5 MMP2 MMP9
2 immune system MP:0005387 9.65 FN1 ITGA3 ITGB5 MMP2 MMP9
3 integument MP:0010771 9.46 FN1 ITGA3 ITGB5 MMP9
4 neoplasm MP:0002006 9.35 FN1 ITGA3 ITGB5 MMP2 MMP9
5 vision/eye MP:0005391 8.92 ITGA3 ITGB5 MMP2 MMP9

Drugs & Therapeutics for Villous Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Villous Adenocarcinoma

Genetic Tests for Villous Adenocarcinoma

Anatomical Context for Villous Adenocarcinoma

MalaCards organs/tissues related to Villous Adenocarcinoma:

41
Colon, Lung, Skin, Heart, Tongue

Publications for Villous Adenocarcinoma

Articles related to Villous Adenocarcinoma:

(show all 12)
# Title Authors Year
1
Complete Endoscopic Submucosal Dissection of a Giant Rectal Villous Adenocarcinoma with Electrolyte Depletion Syndrome. ( 26078730 )
2015
2
A case of Cronkhite-Canada syndrome complicated by McKittrick-Wheelock syndrome associated with advanced villous adenocarcinoma. ( 20887986 )
2011
3
Villous adenocarcinoma of the colon. ( 15897758 )
2005
4
Villous adenocarcinoma of the colon and rectum: a clinicopathologic study of 36 cases. ( 15489649 )
2004
5
Prolapse of the common bile duct with small ampullary villous adenocarcinoma into third part of the duodenum. ( 12876062 )
2003
6
Villous adenocarcinoma of the duodenum invading the ampulla of Vater case report and review of literature. ( 9184865 )
1996
7
Laparoscopic management of appendiceal intussusception associated with villous adenocarcinoma. ( 7833525 )
1994
8
Villous adenocarcinoma arising in the bypassed duodenum 18 years after a Billroth II subtotal gastrectomy: report of a case and review of the literature. ( 3976635 )
1985
9
Villous adenocarcinoma of the male urethra. ( 6644903 )
1983
10
Radiology case of the month. Villous adenoma or villous adenocarcinoma. ( 7230792 )
1981
11
Villous adenocarcinoma of the rectum with severe electrolyte derangement. ( 5413333 )
1970
12
Villous adenocarcinoma of the colon with pronounced electrolyte disturbance. ( 13911186 )
1962

Variations for Villous Adenocarcinoma

Expression for Villous Adenocarcinoma

Search GEO for disease gene expression data for Villous Adenocarcinoma.

Pathways for Villous Adenocarcinoma

Pathways related to Villous Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 41)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.99 FN1 ITGA3 ITGB5 MMP2 MMP9
2
Show member pathways
12.7 FN1 ITGA3 ITGB5
3
Show member pathways
12.61 FN1 ITGA3 ITGB5
4 12.5 FN1 ITGA3 MMP2 MMP9
5 12.37 FN1 ITGA3 ITGB5
6
Show member pathways
12.33 FN1 MMP2 MMP9
7
Show member pathways
12.31 FN1 ITGA3 MMP2
8
Show member pathways
11.9 FN1 ITGA3 ITGB5
9
Show member pathways
11.86 FN1 ITGA3 ITGB5
10
Show member pathways
11.8 FN1 MMP2 MMP9
11 11.78 ITGB5 MMP2 MMP9
12 11.76 FN1 ITGB5 MMP2 MMP9
13 11.73 FN1 MMP2 MMP9
14
Show member pathways
11.68 FN1 ITGA3 ITGB5 MMP2 MMP9
15 11.67 FN1 MMP2
16
Show member pathways
11.67 MMP2 MMP9
17 11.64 FN1 ITGA3
18 11.56 MMP2 MMP9
19 11.56 ITGB5 MMP2 MMP9
20 11.54 ITGA3 MMP9
21 11.52 MMP2 MMP9
22 11.51 FN1 ITGA3 ITGB5
23 11.47 MMP2 MMP9
24 11.46 MMP2 MMP9
25
Show member pathways
11.46 FN1 ITGA3 ITGB5 MMP2 MMP9
26 11.44 MMP2 MMP9
27
Show member pathways
11.44 MMP2 MMP9
28
Show member pathways
11.37 MMP2 MMP9
29 11.33 FN1 MMP2 MMP9
30
Show member pathways
11.29 MMP2 MMP9
31 11.26 FN1 ITGB5
32 11.2 ITGA3 MMP9
33 11.18 FN1 MMP2 MMP9
34 11.13 MMP2 MMP9
35 11.11 FN1 MMP2
36 11.09 MMP2 MMP9
37 11.07 FN1 MMP9
38 11.03 FN1 ITGA3 ITGB5
39 10.98 MMP2 MMP9
40 10.92 MMP2 MMP9
41 10.74 FN1 ITGA3 ITGB5

GO Terms for Villous Adenocarcinoma

Cellular components related to Villous Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix GO:0031012 9.33 FN1 MMP2 MMP9
2 collagen-containing extracellular matrix GO:0062023 9.13 FN1 MMP2 MMP9
3 integrin complex GO:0008305 8.62 ITGA3 ITGB5

Biological processes related to Villous Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.69 FN1 ITGA3 ITGB5
2 cytokine-mediated signaling pathway GO:0019221 9.5 FN1 MMP2 MMP9
3 integrin-mediated signaling pathway GO:0007229 9.49 ITGA3 ITGB5
4 ephrin receptor signaling pathway GO:0048013 9.48 MMP2 MMP9
5 extracellular matrix disassembly GO:0022617 9.46 MMP2 MMP9
6 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.43 MMP2 MMP9
7 leukocyte migration GO:0050900 9.43 FN1 ITGA3 MMP9
8 embryo implantation GO:0007566 9.4 MMP2 MMP9
9 collagen catabolic process GO:0030574 9.37 MMP2 MMP9
10 cell-matrix adhesion GO:0007160 9.33 FN1 ITGA3 ITGB5
11 extracellular matrix organization GO:0030198 9.26 FN1 ITGA3 ITGB5 MMP9
12 endodermal cell differentiation GO:0035987 8.92 FN1 ITGB5 MMP2 MMP9

Molecular functions related to Villous Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metalloendopeptidase activity GO:0004222 9.26 MMP2 MMP9
2 protease binding GO:0002020 9.16 FN1 ITGA3
3 integrin binding GO:0005178 9.13 FN1 ITGA3 ITGB5
4 collagen binding GO:0005518 8.8 FN1 ITGA3 MMP9

Sources for Villous Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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