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MCID: VLL006
MIFTS: 34

Villous Adenoma

Categories: Cancer diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Villous Adenoma

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MalaCards integrated aliases for Villous Adenoma:

Name: Villous Adenoma 12 15
Adenoma, Villous 73
Adenoma Villous 55

Classifications:

MalaCards categories:
Global: Cancer diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0050869
UMLS 73 C0206674
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Summaries for Villous Adenoma

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MalaCards based summary : Villous Adenoma, also known as adenoma, villous, is related to anal canal adenocarcinoma and adenocarcinoma in situ. An important gene associated with Villous Adenoma is CDX2 (Caudal Type Homeobox 2), and among its related pathways/superpathways are Circadian entrainment and fMLP Pathway. The drugs Anti-Inflammatory Agents and Anti-Inflammatory Agents, Non-Steroidal have been mentioned in the context of this disorder. Affiliated tissues include colon, testes and appendix, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 76 Villous adenoma is a type of polyp that grows in the colon and other places in the gastrointestinal... more...

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Related Diseases for Villous Adenoma

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Diseases related to Villous Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 148)
# Related Disease Score Top Affiliating Genes
1 anal canal adenocarcinoma 30.5 CDX2 KRAS
2 adenocarcinoma in situ 30.0 CDX2 KRAS KRT20
3 adenoma 29.7 BRAF GNAS KRAS SST
4 mucinous adenocarcinoma 29.4 CDX2 KRAS KRT20 MUC1
5 adenosquamous carcinoma 29.1 KRAS MUC1
6 adenocarcinoma 29.0 BRAF GNAS KRAS MUC1
7 pseudomyxoma peritonei 28.9 CDX2 KRAS KRT20 MUC1
8 colorectal adenocarcinoma 28.5 BRAF CDX2 KRAS KRT20
9 urinary bladder villous adenoma 12.1
10 urethral villous adenoma 12.1
11 vaginal villous adenoma 12.1
12 vaginal benign neoplasm 10.7 CDX2 KRT20
13 appendix adenocarcinoma 10.7 CDX2 KRT20
14 vaginal adenoma 10.7 CDX2 KRT20
15 vaginal tubulovillous adenoma 10.7 CDX2 KRT20
16 glandular cystitis 10.7 CDX2 KRT20
17 ovarian mucinous adenocarcinoma 10.7 CDX2 KRT20
18 thymus adenocarcinoma 10.7 CDX2 KRT20
19 gastric diffuse adenocarcinoma 10.6 CDX2 KRT20
20 bladder adenocarcinoma 10.6 CDX2 KRT20
21 jejunal adenocarcinoma 10.6 CDX2 KRT20
22 chronic cystitis 10.6 CDX2 KRT20
23 vulva adenocarcinoma 10.6 CDX2 KRT20
24 rectum adenocarcinoma 10.6 CDX2 KRT20
25 ovary serous adenocarcinoma 10.6 GNAS KRAS
26 seminal vesicle adenocarcinoma 10.6 KLK3 KRT20
27 ovarian cystadenocarcinoma 10.6 GNAS KRAS
28 endocervical adenocarcinoma 10.6 CDX2 KRT20
29 bronchiolo-alveolar adenocarcinoma 10.6 CDX2 KRAS
30 nasal cavity adenocarcinoma 10.6 CDX2 KRAS
31 prostatic acinar adenocarcinoma 10.6 KLK3 KRT20
32 ovarian mucinous neoplasm 10.6 CDX2 KRT20
33 cystic teratoma 10.5 CDX2 KRT20
34 rete testis adenocarcinoma 10.5 KLK3 KRT20
35 horseshoe kidney 10.5 CDX2 KRT20
36 hormone producing pituitary cancer 10.5 GNAS SST
37 adenoma of the pancreas 10.5 KRT20 SST
38 rete testis neoplasm 10.5 KLK3 KRT20
39 growth hormone secreting pituitary adenoma 10.4 GNAS SST
40 anus cancer 10.4 CDX2 KRAS
41 periampullary adenoma 10.4 KRAS SST
42 pancreatic intraductal papillary-mucinous neoplasm 10.4 GNAS MUC1
43 tumor of exocrine pancreas 10.4 GNAS MUC1
44 bile duct cystadenocarcinoma 10.4 KRT20 MUC1
45 nodular prostate 10.4 FOLH1 KLK3
46 gastrointestinal system benign neoplasm 10.3 CDX2 KRAS
47 hepatoid adenocarcinoma 10.3 CDX2 MUC1
48 apocrine adenoma 10.3 KRAS MUC1
49 paget disease, extramammary 10.3 KRT20 MUC1
50 mucinous cystadenocarcinoma 10.3 KRT20 MUC1

Graphical network of the top 20 diseases related to Villous Adenoma:



Diseases related to Villous Adenoma
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Symptoms & Phenotypes for Villous Adenoma

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GenomeRNAi Phenotypes related to Villous Adenoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.47 BRAF KRAS MUC1
2 Decreased viability GR00106-A-0 9.47 KRAS
3 Decreased viability GR00221-A-1 9.47 KRAS
4 Decreased viability GR00221-A-2 9.47 KRAS
5 Decreased viability GR00221-A-4 9.47 BRAF
6 Decreased viability GR00301-A 9.47 BRAF KRAS
7 Decreased viability GR00381-A-1 9.47 BRAF KRAS
8 Decreased viability GR00402-S-2 9.47 BRAF KRAS MUC1
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Drugs & Therapeutics for Villous Adenoma

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Drugs for Villous Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anti-Inflammatory Agents Phase 3
2 Anti-Inflammatory Agents, Non-Steroidal Phase 3
3 Cola Nutraceutical Phase 3,Phase 2,Not Applicable
4
Epigallocatechin gallate Investigational Phase 2 989-51-5 65064
5
Catechin Nutraceutical Phase 2 154-23-4 9064
6
Epicatechin Investigational, Nutraceutical Phase 2 490-46-0 72276
7
Epigallocatechin Experimental, Investigational, Nutraceutical Phase 2 970-74-1 72277
8 Tea Nutraceutical Phase 2
9
Menthol Approved Not Applicable 2216-51-5 16666
10
Aspirin Approved, Vet_approved 50-78-2 2244
11
Midazolam Approved, Illicit 59467-70-8 4192

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Trial of Low Dose Sulindac Combined With Eflornithine in Patients With Familial Adenomatous Polyposis (FAP) Withdrawn NCT01245816 Phase 3 Eflornithine plus Sulindac;Eflornithine plus Placebo;Sulindac plus Placebo
2 Minimizing the Risk of Metachronous Adenomas of the Colorectum With Green Tea Extract -MIRACLE- Unknown status NCT01360320 Phase 2
3 Study of In-home Tests for Colorectal Cancer Completed NCT01998009 Not Applicable
4 Complete Histologic Resection of Adenomatous Polyps? Completed NCT01224444
5 To Investigate Risk of Colorectal Neoplasms in First-degree Relatives of Patients With Non-advanced Adenomas Completed NCT02521727
6 Diagnostic Accuracy of NICE Classification to Predict Deep Submucosal Invasion Completed NCT02328066 Not Applicable
7 Use of Accessory Device AmplifEYE During Average Risk Screening Colonoscopy to Increase Adenoma Detection Rate Recruiting NCT02885987 Not Applicable
8 Personalized Surveillance Protocol for Serrated Polyposis Syndrome Active, not recruiting NCT03450889

Search NIH Clinical Center for Villous Adenoma

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Genetic Tests for Villous Adenoma

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Anatomical Context for Villous Adenoma

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MalaCards organs/tissues related to Villous Adenoma:

41
Colon, Testes, Appendix, Prostate
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Publications for Villous Adenoma

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Articles related to Villous Adenoma:

(show top 50) (show all 71)
# Title Authors Year
1
Endoanal resection of a giant villous adenoma in the middle rectum - Video Vignette. ( 29364560 )
2018
2
A case of urachal villous adenoma with high grade dysplasia focally bordering on adenocarcinoma in situ. ( 29321972 )
2018
3
Villous adenoma of the urachal remnant: A diagnostic conundrum. ( 29899888 )
2018
4
Robotic approach to resection of villous adenoma of the urachus: a case report and literature review. ( 28889213 )
2017
5
A villous adenoma of bladder/urachus origin located in the perineum. ( 28727697 )
2017
6
Pure Villous Adenoma of the Vesicoureteric Junction Presenting as Pyonephrosis. ( 28969142 )
2017
7
Villous Adenoma in Renal Pelvis with Manifestation of Percutaneous Fistula and Mucus Secretion. ( 28069333 )
2017
8
Indomethacin therapy effective in a patient with depletion syndrome from secretory villous adenoma. ( 28188165 )
2017
9
Villous Adenoma of the Urinary Bladder: A Brief Review of the Literature. ( 26717061 )
2016
10
Cytopathological features of villous adenoma of the urinary bladder in urine: A rare case report. ( 27121034 )
2016
11
Common bile duct villous adenoma: a case report and review of the literature. ( 26795920 )
2016
12
Villous Adenoma Arising at the Hepaticojejunostomy Site (HJ Site): First Report of an Unusual Case. ( 27406827 )
2016
13
Villous adenoma of the common hepatic duct: the importance of contrast-enhanced ultrasound and endoscopic retrograde cholangiopancreatography for relevant diagnosis. A case report and review of the literature. ( 26649355 )
2015
14
Poorly Differentiated Neuroendocrine Tumor of the Rectum Coexistent with Giant Rectal Villous Adenoma Presenting as McKittrick-Wheelock Syndrome. ( 26682079 )
2015
15
Giant villous adenoma of rectum mimicking an infiltrating adenocarcinoma. ( 26710491 )
2015
16
Clinicopathological analysis of two cases with pelvis villous adenoma and review of relevant literature. ( 26458689 )
2015
17
Concurrence of primary malignant melanoma of the esophagus with adenocarcinoma of sigmoid colon and villous adenoma of cecum: a case presentation. ( 26629222 )
2015
18
Villous adenoma of the urinary bladder. ( 26458700 )
2015
19
Large Tubullo-villous Adenoma of Duodenum Presenting as Gastric Outlet Obstruction. ( 26816945 )
2015
20
Intussusception by Villous Adenoma of the Appendix. ( 27011572 )
2015
21
Frequent lack of GNAS mutations in colorectal adenocarcinoma associated with GNAS-mutated villous adenoma. ( 24470207 )
2014
22
Villous adenoma in gallbladder volvulus: A rare coincidence. ( 25910354 )
2014
23
Mucinous adenocarcinoma of the umbilicus 8 years following anterior resection for villous adenoma of the rectum. ( 24876318 )
2014
24
Giant rectal villous adenoma: Surgical approach with rectal eversion and perianal coloanal anastomosis. ( 24441716 )
2014
25
Villous adenoma of duodenum: a rare case presentation with review of literature. ( 24426722 )
2013
26
Renal pelvic villous adenoma presented with mucusuria: report of a case and literature review. ( 22934691 )
2013
27
Education and imaging: gastrointestinal: villous adenoma of the ampulla of Vater causing acute pancreatitis. ( 23339391 )
2013
28
Hypersecretory villous adenoma as the primary cause of an intestinal intussusception and McKittrick-Wheelock syndrome. ( 24199207 )
2013
29
Concurrence of villous adenoma and non-muscle invasive bladder cancer arising in the bladder: a case report and review of the literature. ( 23870731 )
2013
30
Editorial Comment to renal pelvic villous adenoma presented with mucusuria: report of a case and literature review. ( 22994387 )
2013
31
Primary intestinal type adenocarcinoma of the female genital tract, arisen from a tubulo-villous adenoma: Case report. ( 24371679 )
2013
32
Acute renal failure and metabolic alkalosis in a patient with colorectal villous adenoma (McKittrick-Wheelock syndrome). ( 22749370 )
2013
33
Intestinal type villous adenoma of the renal pelvis. ( 23671505 )
2013
34
Recurrent pancreatitis caused by pancreatic ductal villous adenoma treated with endoscopic snare polypectomy. ( 23468150 )
2013
35
McKittrick-Wheelock syndrome - Prolapsed giant villous adenoma of the rectum. ( 23971670 )
2013
36
Large villous adenoma of gallbladder: A case report. ( 23276760 )
2013
37
A giant rectal villous adenoma with a malicious intent. ( 24312688 )
2013
38
Villous adenoma of the appendix: management recommendations. ( 23317609 )
2013
39
Villous adenoma of gallbladder in a patient with systemic lupus erythematosus. ( 23798953 )
2012
40
Frequent activating GNAS mutations in villous adenoma of the colorectum. ( 22374786 )
2012
41
Carpet villous adenoma of the rectum in an incarcerated rectal prolapse. ( 23923364 )
2012
42
'Volcano sign' and endoscopic mucosal resection of a villous adenoma arising from the appendix. ( 22387285 )
2012
43
Endoscopic ultrasound guided fine-needle aspiration diagnosis of duodenal high grade neuroendocrine carcinoma underlying a villous adenoma: report of a case. ( 22180240 )
2012
44
Differentiation of tubular and villous adenomas based on Wnt pathway-related gene expression profiles. ( 20514431 )
2010
45
Giant villous adenoma and McKittrick-Wheelock syndrome in an incarcerated rectal prolapse. ( 19220372 )
2010
46
[A case of early bile duct cancer arising from villous adenoma in choledochal cyst]. ( 19696552 )
2009
47
Recurrent villous adenoma with high-grade dysplasia arising in a urethral diverticulum. ( 19718251 )
2009
48
A Giant Mucinous Adenocarcinoma Arising within a Villous Adenoma of the Urachus: Case Report and Review of the Literature. ( 20182635 )
2009
49
CpG island methylation is frequently present in tubulovillous and villous adenomas and correlates with size, site, and villous component. ( 17950780 )
2008
50
Immunohistochemical expression of prostatic antigens in adenocarcinoma and villous adenoma of the urinary bladder. ( 18670358 )
2008
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Variations for Villous Adenoma

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Cosmic variations for Villous Adenoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)		 Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM532 KRAS large intestine,colon,adenoma,villous c.38G>A p.G13D 12:25245347-25245347 11
2 COSM520 KRAS large intestine,colon,adenoma,villous c.35G>T p.G12V 12:25245350-25245350 11
3 COSM521 KRAS large intestine,colon,adenoma,villous c.35G>A p.G12D 12:25245350-25245350 11
4 COSM517 KRAS large intestine,colon,adenoma,villous c.34G>A p.G12S 12:25245351-25245351 11
5 COSM27887 GNAS large intestine,colon,adenoma,villous c.601C>T p.R201C 20:58909365-58909365 11
6 COSM27895 GNAS large intestine,colon,adenoma,villous c.602G>A p.R201H 20:58909366-58909366 11
7 COSM22971 FBXW7 large intestine,colon,adenoma,villous c.832C>T p.R278* 4:152337831-152337831 11
8 COSM476 BRAF large intestine,colon,adenoma,villous c.1799T>A p.V600E 7:140753336-140753336 11
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Expression for Villous Adenoma

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Search GEO for disease gene expression data for Villous Adenoma.
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Pathways for Villous Adenoma

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Pathways related to Villous Adenoma according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Circadian entrainment 37
Show member pathways
 12.67 FOLH1 GNAS KRAS KRT20
2
fMLP Pathway 64
Show member pathways
 12.66 BRAF CDX2 GNAS KRAS
3
Pathways in cancer 37
12.34 BRAF GNAS KLK3 KRAS
4
Beta-Adrenergic Signaling 64
Show member pathways
 12.15 BRAF GNAS KLK3 KRAS
5
Long-term potentiation 37
Show member pathways
 11.8 BRAF GNAS KRAS
6
Colorectal Cancer Metastasis 64
11.76 BRAF GNAS KRAS
7
Serotonergic synapse 37
11.18 BRAF GNAS KRAS
8
Vemurafenib Pathway, Pharmacodynamics 61
11.15 BRAF KRAS
9
BDNF-TrkB Signaling 1
11.01 BRAF KRAS
10
G-protein signaling_K-RAS regulation pathway 22
10.89 BRAF KRAS
11
Estrogen signaling pathway 1
10.79 BRAF GNAS
12
Long-term depression 37
10.58 BRAF GNAS KRAS
13
Serotonin Receptor 4/6/7 and NR3C Signaling 1
10.54 BRAF GNAS
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GO Terms for Villous Adenoma

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Biological processes related to Villous Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 visual learning GO:0008542 8.62 BRAF KRAS
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Sources for Villous Adenoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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