Villous Adenoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: VLL006 MIFTS: 40	Villous Adenoma Categories: Cancer diseases, Gastrointestinal diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Villous Adenoma

MalaCards integrated aliases for Villous Adenoma:

Name: Villous Adenoma ¹² ¹⁵

Adenoma, Villous ⁷⁰

Adenoma Villous ⁵⁴

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Gastrointestinal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0050869

UMLS ⁷⁰ C0206674

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Summaries for Villous Adenoma

Disease Ontology : ¹² An adenoma that is located in the colon and other places in the gastrointestinal tract and sometimes in other parts of the body.

MalaCards based summary : Villous Adenoma, also known as adenoma, villous, is related to urethral villous adenoma and urinary bladder villous adenoma. An important gene associated with Villous Adenoma is GNAS (GNAS Complex Locus), and among its related pathways/superpathways are Beta-Adrenergic Signaling and Development HGF signaling pathway. The drugs Catechin and Epigallocatechin gallate have been mentioned in the context of this disorder. Affiliated tissues include colon, appendix and pancreas, and related phenotypes are Decreased viability and Decreased viability

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Related Diseases for Villous Adenoma

Diseases related to Villous Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 514)

#	Related Disease	Score	Top Affiliating Genes
1	urethral villous adenoma	32.2	KRT7 KRT20 CEACAM5
2	urinary bladder villous adenoma	31.0	MUC6 MUC5AC MUC1 KRT7 KRT20 CEACAM5
3	urachal adenocarcinoma	30.4	KRAS GNAS CEACAM5 BRAF
4	in situ carcinoma	30.3	TP53 MUC1 KRT8 HRAS
5	neuroendocrine carcinoma	30.1	SST MUC1 KRT7 KRT20 CEACAM5
6	urethral diverticulum	30.1	KRT7 KLK3
7	meckel diverticulum	30.1	SST KRT7 CDX2
8	appendix adenocarcinoma	30.0	KRT7 KRT20 KRAS HRAS GNAS CDX2
9	squamous cell papilloma	30.0	TP53 HRAS
10	neuroendocrine tumor	30.0	SST KRT20 HRAS CDX2
11	bladder adenocarcinoma	29.9	KRT7 KRT20 KLK3 CDX2
12	mammary paget's disease	29.9	MUC1 KRT8 KRT7 KRT20
13	adenocarcinoma in situ	29.8	KRT7 KRT20 KRAS CEACAM5 CDX2
14	bladder urothelial carcinoma	29.7	TP53 KRT20 KRAS HRAS BRAF
15	intestinal obstruction	29.7	KRT7 KRT20 CEACAM5 CDX2
16	gastrointestinal carcinoma	29.7	TP53 MUC1 KRT20 CEACAM5 CDX2
17	glandular cystitis	29.7	TP53 MUC5AC MUC1 KRT7 KRT20 CDX2
18	bile duct adenoma	29.6	TP53 MUC1 KRT7 KRT20
19	papilloma	29.6	TP53 KRT8 KRT7 KRT20 KRAS
20	colorectal adenoma	29.6	TP53 MLH1 KRAS HRAS APC
21	bile duct cysts	29.6	KRT7 KRAS HRAS CEACAM5
22	appendiceal neoplasm	29.5	KRT7 KRAS HRAS GNAS CEACAM5 CDX2
23	anal canal adenocarcinoma	29.5	MUC5AC KRT7 KRT20 CEACAM5 CDX2
24	rectum cancer	29.3	MLH1 KRT20 KRAS HRAS CEACAM5 APC
25	cholecystitis	29.2	TP53 MUC6 MUC5AC MUC1
26	familial adenomatous polyposis	29.1	TP53 MLH1 KRAS HRAS APC
27	mucoepidermoid carcinoma	29.1	TP53 MUC5AC MUC1 KRT7 CEACAM5
28	cervical adenocarcinoma	29.1	TP53 KRT7 KRT20 KRAS CEACAM5 CDX2
29	adenoma	29.1	TP53 SST MUC6 MUC5AC MUC1 MLH1
30	papillary adenoma	29.1	TP53 KRT7 KRAS HRAS CEACAM5
31	intrahepatic cholangiocarcinoma	29.1	TP53 MUC5AC MUC1 KRT7 KRT20 KRAS
32	small cell carcinoma	29.0	TP53 MUC1 KRT8 KRT7 KRT20 KRAS
33	adenosquamous carcinoma	29.0	TP53 MUC1 KRT8 KRT7 KRAS CEACAM5
34	mucinous adenocarcinoma	28.7	TP53 MUC5AC MUC1 MLH1 KRT7 KRT20
35	bladder cancer	28.6	TP53 MUC1 MLH1 KRT8 KRT20 KRAS
36	transitional cell carcinoma	28.6	TP53 MLH1 KRT8 KRT7 KRT20 KLK3
37	intestinal benign neoplasm	28.6	TP53 MLH1 KRAS HRAS CEACAM5 CDX2
38	renal cell carcinoma, nonpapillary	28.6	TP53 MUC1 KRT8 KRT7 KRT20 HRAS
39	barrett esophagus	28.4	TP53 MUC6 MUC5AC KRT7 KRT20 CDX2
40	rectum adenocarcinoma	28.3	TP53 MLH1 KRT7 KRT20 KRAS HRAS
41	adenocarcinoma	28.3	TP53 MUC1 MLH1 KRT7 KRT20 KRAS
42	duodenum adenocarcinoma	28.3	MUC6 MUC5AC MLH1 KRT7 KRAS HRAS
43	cholangiocarcinoma	28.2	TP53 MUC5AC MUC1 KRT8 KRT7 KRT20
44	gastric adenocarcinoma	28.1	TP53 MLH1 KRT20 KRAS HRAS GNAS
45	pseudomyxoma peritonei	27.8	TP53 MUC6 MUC5AC MUC1 KRT7 KRT20
46	colorectal adenocarcinoma	27.7	TP53 MUC1 MLH1 KRT7 KRT20 KRAS
47	signet ring cell adenocarcinoma	27.4	TP53 MUC6 MUC5AC MUC1 MLH1 KRT7
48	duodenum cancer	27.4	TP53 SST MUC6 MUC5AC MUC1 MLH1
49	lung cancer susceptibility 3	27.2	TP53 MUC5AC MUC1 MLH1 KRT7 KRT20
50	bile duct cancer	26.9	TP53 MUC6 MUC5AC MUC1 MLH1 KRT7

Graphical network of the top 20 diseases related to Villous Adenoma:

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Symptoms & Phenotypes for Villous Adenoma

GenomeRNAi Phenotypes related to Villous Adenoma according to GeneCards Suite gene sharing:

²⁶ (show all 34)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00055-A-1	10	BRAF HRAS KRAS MUC1
2	Decreased viability	GR00055-A-2	10	BRAF HRAS KRAS MUC1
3	Decreased viability	GR00055-A-3	10	KRAS
4	Decreased viability	GR00106-A-0	10	KRAS
5	Decreased viability	GR00221-A-1	10	HRAS KRAS
6	Decreased viability	GR00221-A-2	10	HRAS KRAS
7	Decreased viability	GR00221-A-3	10	HRAS
8	Decreased viability	GR00221-A-4	10	BRAF
9	Decreased viability	GR00249-S	10	BRAF MUC1
10	Decreased viability	GR00301-A	10	BRAF KRAS
11	Decreased viability	GR00381-A-1	10	BRAF KRAS
12	Decreased shRNA abundance (Z-score < -2)	GR00366-A-177	9.76	APC
13	Decreased shRNA abundance (Z-score < -2)	GR00366-A-29	9.76	APC
14	Decreased shRNA abundance (Z-score < -2)	GR00366-A-49	9.76	APC
15	Decreased shRNA abundance (Z-score < -2)	GR00366-A-6	9.76	KRT8
16	Decreased shRNA abundance (Z-score < -2)	GR00366-A-71	9.76	KRT7 KRT8
17	Decreased shRNA abundance (Z-score < -2)	GR00366-A-72	9.76	APC
18	Decreased shRNA abundance (Z-score < -2)	GR00366-A-74	9.76	APC
19	Increased shRNA abundance (Z-score > 2)	GR00366-A-1	9.62	MLH1
20	Increased shRNA abundance (Z-score > 2)	GR00366-A-124	9.62	MLH1
21	Increased shRNA abundance (Z-score > 2)	GR00366-A-126	9.62	KRT8
22	Increased shRNA abundance (Z-score > 2)	GR00366-A-133	9.62	APC
23	Increased shRNA abundance (Z-score > 2)	GR00366-A-135	9.62	KRT7 KRT8
24	Increased shRNA abundance (Z-score > 2)	GR00366-A-180	9.62	KRT8
25	Increased shRNA abundance (Z-score > 2)	GR00366-A-192	9.62	APC KRT7 KRT8
26	Increased shRNA abundance (Z-score > 2)	GR00366-A-195	9.62	MLH1
27	Increased shRNA abundance (Z-score > 2)	GR00366-A-200	9.62	MLH1
28	Increased shRNA abundance (Z-score > 2)	GR00366-A-202	9.62	APC
29	Increased shRNA abundance (Z-score > 2)	GR00366-A-40	9.62	KRT8
30	Increased shRNA abundance (Z-score > 2)	GR00366-A-68	9.62	KRT7
31	Increased shRNA abundance (Z-score > 2)	GR00366-A-72	9.62	KRT7
32	Increased shRNA abundance (Z-score > 2)	GR00366-A-74	9.62	KRT7 KRT8
33	Increased shRNA abundance (Z-score > 2)	GR00366-A-78	9.62	MLH1
34	Increased shRNA abundance (Z-score > 2)	GR00366-A-91	9.62	KRT7

MGI Mouse Phenotypes related to Villous Adenoma:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	digestive/alimentary	MP:0005381	9.85	APC BRAF CDX2 HRAS KRAS KRT8
2	neoplasm	MP:0002006	9.61	ACP3 APC BRAF CDX2 GNAS HRAS
3	normal	MP:0002873	9.28	APC BRAF CDX2 GNAS HRAS KLK3

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Drugs & Therapeutics for Villous Adenoma

Drugs for Villous Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Catechin

Approved, Withdrawn

Phase 2

154-23-4

9064

Synonyms:

(-)-Epicatechin

(+)-(2R,3S)-5,7,3',4'-Tetrahydroxyflavan-3-ol

(+)-3',4',5,7-Tetrahydroxy-2,3-trans-flavan-3-ol

(+)-catechin

(+)-Catechin

(+)-Catechin hydrate

(+)-Catechol

(+)-Cyanidan-3-ol

(+)-Cyanidanol

(+)-Cyanidanol-3

(+/-)-catechin

(+/-)-catechin hydrate

(2R,3S)-(+)-Catechin

(2R,3S)-catechin

(2R,3S)-Catechin

(2R-trans)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3,5,7-triol

3,3',4',5,7-Flavanpentol

Acid, catechinic

Acid, catechuic

Biocatechin

Catechin

Catechinate

Catechinic acid

Catechuate

Catechuic acid

Catergen

Cianidanol

Cianidanolum

Cianidol

Cyanidanol

Cyanidanol 3

Cyanidanol-3

D-(+)-Catechin

d-Catechin

D-Catechin

D-Catechol

Epicatechin

KB 53

KB-53

trans3,3,4,5,7 Pentahydroxyflavane

YK-85 light yellow powder 85

Zyma

Epigallocatechin gallate

Investigational

Phase 2

989-51-5

65064

Synonyms:

(-)-Epigallocatechin gallat

(-)-Epigallocatechin gallate

(-)-Epigallocatechin-3-O-gallate

(-)-Epigallocatechin-3-O-gallic acid

(-)-Epigallocatechol gallate

(-)-Epigallocatehin gallate

[(2R,3R)-5,7-Dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate

[(2R,3R)-5,7-Dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoic acid

Catechin deriv.

EGCG

EGCG CPD

Epigallocatcchin gallate

Epigallocate

Epigallocatechin 3-gallate

Epigallocatechin 3-gallic acid

Epigallocatechin gallate

Epigallo-catechin gallate

Epigallocatechin gallic acid

Epigallocatechin-3-gallate

Epigallocatechin-3-O-gallate

Epigallocic acid

Galloyl-L-epigallocatechol

Sunphenon

Tea catechin

Epigallocatechin

Experimental, Investigational

Phase 2

970-74-1

72277

Synonyms:

(-)-3,3',4',5,5',7-Flavanhexol

(-)-3,3’,4’,5,5’,7-Flavanhexol

(-)-cis-3,3',4',5,5',7-Hexahydroxyflavan

(-)-cis-3,3',4',5,5',7-Hexahydroxyflavane

(-)-epigallocatechin

(-)-epi-gallocatechin

(−)-epigallocatechin

(-)-epi-Gallocatechin

(-)-Epigallocatechin

(-)-epigallocatechol

(-)-Epigallocatechol

(2R,3R)-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol

(2R,3R)-2-(3,4,5-Trihydroxyphenyl)-3,5,7-trihydroxychroman

(2R,3R)-3,4-Dihydro-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3,5,7-triol

1-epi-3',4',5',5,7-Pentahydroxy-3-flavanol

1-epi-3’,4’,5’,5,7-Pentahydroxy-3-flavanol

2,3-cis-Epigallocatechin

3,3',4',5,5',7-flavanhexol

3,3',4',5,5',7-Flavanhexol

3,3’,4’,5,5’,7-Flavanhexol

Antiscurvy factor C2

EGC

epi-Gallocatechin

Epigallocatechin

Epi-gallocatechin

Epigallocatechol

Gallocatechin

Gallocatechol

Gallocatechol, (2R-cis)-isomer

Gallocatechol, (2R-trans)-isomer

Galloepicatechin

L-epigallocatechin

L-Epigallocatechin

L-Epigallocatechol

Epicatechin

Investigational

Phase 2

490-46-0

72276

Synonyms:

(-)-Epicatechin

(-)-Epicatechol

(+)-Catechin

(+)-Cyanidanol

(+)-Cyanidanol-3

(2R,3R)-(-)-Epicatechin

3,3',4',5,7-Flavanpentol

3,3',4',5,7-Pentahydroxyflavane

Acid, catechinic

Acid, catechuic

alpha-Catechin

Catechin

Catechinic acid

Catechuic acid

Catergen

Cianidanol

Cyanidanol 3

Cyanidanol-3

Epicatechol

Epigallocatechin

KB 53

KB-53

L(-)-Epicatechin

L-Acacatechin

L-Epicatechin

L-Epicatechol

Zyma

Cola

Phase 2

Tea

Phase 2

Interventional clinical trials:

#	Name	Status	NCT ID	Phase
1	Minimizing the Risk of Metachronous Adenomas of the Colorectum With Green Tea Extract -MIRACLE-	Completed	NCT01360320	Phase 2
2	Outcomes of Endoscopic Resection of Mucosal and Submucosal Lesions in the Duodenum and Ampulla	Recruiting	NCT02306603
3	Outcomes of Endoscopic Resection in the Upper Gastrointestinal Tract	Recruiting	NCT02305290
4	Outcomes of Endoscopic Resection of Mucosal and Submucosal Lesions in the Stomach.	Recruiting	NCT02306707

Search NIH Clinical Center for Villous Adenoma

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Genetic Tests for Villous Adenoma

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Anatomical Context for Villous Adenoma

The Foundational Model of Anatomy Ontology organs/tissues related to Villous Adenoma:

¹⁹

Colon

MalaCards organs/tissues related to Villous Adenoma:

⁴⁰

Colon, Appendix, Pancreas, Kidney, Prostate, Lymph Node, Small Intestine

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Publications for Villous Adenoma

Articles related to Villous Adenoma:

(show top 50) (show all 988)

#	Title	Authors	PMID	Year
1	Aberrant expression of a human mucin gene (MUC5AC) in rectosigmoid villous adenoma. ⁵⁴ ⁶¹	Buisine MP...Porchet N	8536891	1996
2	Differential Expression Profiles of Mitogenome Associated MicroRNAs Among Colorectal Adenomatous Polyps. ⁶¹	Wallace L...Aikhionbare F	33628862	2021
3	Molecular profiling of appendiceal serrated lesions, polyps and mucinous neoplasms: a single-centre experience. ⁶¹	Munari G...Fassan M	33712927	2021
4	Telomerase reverse transcriptase (TERT) promoter mutations in primary adenocarcinoma of bladder and urothelial carcinoma with glandular differentiation: pathogenesis and diagnostic implications. ⁶¹	Cheng L...Zhang S	33674765	2021
5	Villous adenoma of the urethra. ⁶¹	Dowd KE...Bird ET	33678969	2021
6	Giant Villous Adenoma: A Rare Case of Colorectal Adenoma that Mimic Colorectal Cancer. ⁶¹	Ferdaus AM...Rahman MH	33397878	2021
7	Giant villous adenoma of the sigmoid colon: an unusual cause of homogeneous, segmental bowel wall thickening. ⁶¹	Sacks J...Kirwan A	33299583	2020
8	Non-conventional dysplasia in inflammatory bowel disease is more frequently associated with advanced neoplasia and aneuploidy than conventional dysplasia. ⁶¹	Lee H...Choi WT	33155325	2020
9	Reliability in villous tumors staging between preoperative MRI and histopathological examination. ⁶¹	Vogrig C...Laurent V	32123949	2020
10	Transanal minimally invasive surgery (TAMIS) for rectal tumor: a case report and literature review. ⁶¹	Wang H...Cai Y	33145320	2020
11	Villous adenoma of the urachus obscuring urachal adenocarcinoma: A case report. ⁶¹	Nishikawa Y...Isoyama T	32477881	2020
12	Molecular Genetic Features of Primary Nonurachal Enteric-type Adenocarcinoma, Urachal Adenocarcinoma, Mucinous Adenocarcinoma, and Intestinal Metaplasia/Adenoma: Review of the Literature and Next-generation Sequencing Study. ⁶¹	Pires-Luis AS...Hes O	32520749	2020
13	Villous Adenoma Arising in the Urethra of a Female with Bladder Augmentation History: A Case Report and Review of the Literature. ⁶¹	Demir H...Uygun N	32779155	2020
14	Adult duodenal intussusception with horizontal adenoma: A rare case report. ⁶¹	Wang KP...Jin C	32874987	2020
15	A rare case of huge villous adenoma of the renal pelvis deforming the abdominal wall. ⁶¹	Stoykov B...Mateva S	32309146	2020
16	Colonoscopy in patients with psoriasis before the initiation of treatment with biological agents. ⁶¹	Tamer F...Yuksel ME	32506694	2020
17	Nomograms that predict the survival of patients with adenocarcinoma in villous adenoma of the colorectum: a SEER-based study. ⁶¹	Tang CT...Chen Y	32600342	2020
18	Lessons of the month 2: McKittrick-Wheelock syndrome: Case report of a patient declining resection of a large villous adenoma. ⁶¹	Murugachandran J...Gannon D	32414717	2020
19	Endoscopic resection of a prolapsing giant villous adenoma of the supraanal rectum. ⁶¹	Zimmer V...Eltze E	31447294	2020
20	Evaluation of a Deep Neural Network for Automated Classification of Colorectal Polyps on Histopathologic Slides. ⁶¹	Wei JW...Hassanpour S	32324237	2020
21	Villous Morphology in Urinary Bladder Biopsy: An Approach to Diagnosis. ⁶¹	Mitra S...Kaur G	31409167	2020
22	Endocytoscopic Observation of Non-Ampullary Mucosal Duodenal Cancer. ⁶¹	Kumagai Y...Ishida H	32355485	2020
23	A histopathological rarity: Primary signet ring cell carcinoma arising within a colonic villous adenoma. ⁶¹	Jacob S...Zayyani NR	32031145	2020
24	Urinary tract villous adenoma in Indonesia. ⁶¹	Pramod SV...Wijayanti Z	31687348	2019
25	Effect of Supplementation With Marine ω-3 Fatty Acid on Risk of Colorectal Adenomas and Serrated Polyps in the US General Population: A Prespecified Ancillary Study of a Randomized Clinical Trial. ⁶¹	Song M...VITAL Research Group	31750855	2019
26	Intussusception in the Setting of Tuberous Sclerosis Complex. ⁶¹	Zhornitskiy A...Tabibian JH	31832470	2019
27	Laparoscopic Pancreas-Sparing Duodenectomy with Roux en Y Reconstruction for Duodenal Polyposis. ⁶¹	Copaescu C...Saftoiu A	31511136	2019
28	Giant villous adenoma of rectum- what is the malignant potential and what is the optimal treatment? A case and review of literature. ⁶¹	Bains L...Singh M	31238922	2019
29	Villous Adenoma Arising in the Native Bladder Mucosa and the Upper Urinary Tract With Coexisting Neuroendocrine Carcinoma Following Augmentation Cystoplasty. ⁶¹	Nayak A...Lal P	30701999	2019
30	Villous adenoma coexistent with focal well-differentiated adenocarcinoma of female urethral orifice: A case report and review of literature. ⁶¹	Qin LF...Niu HT	31024961	2019
31	Recurrence of adenoma after curative endoscopic submucosal dissection for a rectal intramucosal adenocarcinoma in adenoma. ⁶¹	Nakano Y...Kodama Y	30993167	2019
32	A Rare Case of Acute Kidney Injury: McKittrick Wheelock Syndrome. ⁶¹	Guney I...Omeroglu E	30988251	2019
33	Photodynamic therapy as salvage therapy for residual microscopic cancer after ultra-low anterior resection: A case report. ⁶¹	Zhang SQ...Zhao H	30968047	2019
34	Cancer risk in microscopic colitis: a retrospective cohort study. ⁶¹	Levy A...Ananthakrishnan AN	30611218	2019
35	Tubulo-villous adenoma of the appendix: A case report and review of the literature. ⁶¹	Evola G...Reina GA	31349156	2019
36	[A case of rectal villous adenoma with electrolyte depletion syndrome treated with surgical resection]. ⁶¹	Suzuki N...Yoshida H	31292319	2019
37	McKittrick-Wheelock Syndrome Presenting with Acute Kidney Injury and Metabolic Alkalosis: Case Report and Narrative Review. ⁶¹	Caron M...Lafleur A	30838142	2019
38	Precursor lesions of the urinary bladder. ⁶¹	McKenney JK	30565304	2019
39	Is magnetic resonance imaging useful for the management of patients with rectal villous adenoma? A study of 45 consecutive patients treated by transanal endoscopic microsurgery. ⁶¹	Raynaud L...Panis Y	30136172	2018
40	Should asymptomatic young men with iron deficiency anemia necessarily undergo endoscopy? ⁶¹	Kim NH...Jung YS	29294595	2018
41	[Risk analysis of the canceration of colorectal large polyps]. ⁶¹	Jin Y...Gong L	30370516	2018
42	Villous adenoma of the choledocho: an infrequent pathology of the main bile duct. ⁶¹	Garcia Bernardo CM...Solar Garcia L	30286605	2018
43	A systematic review of McKittrick-Wheelock syndrome. ⁶¹	Orchard MR...McCarthy K	30322287	2018
44	Intestinal-type adenocarcinoma of the vagina: clinico-pathologic features of a common tumor with a rare localization. ⁶¹	Broggi G...Vecchio GM	30546144	2018
45	Analysis of Syndecan-2 Methylation in Bowel Lavage Fluid for the Detection of Colorectal Neoplasm. ⁶¹	Park YS...Chae JD	29730903	2018
46	Robotic approach to resection of villous adenoma of the urachus: a case report and literature review. ⁶¹	Chen A...Mehrazin R	28889213	2018
47	Colonoscopy conversion after flexible sigmoidoscopy screening: results from the UK Bowel Scope Screening Programme. ⁶¹	Siau K...Murugananthan A	29205835	2018
48	Endoanal resection of a giant villous adenoma in the middle rectum - a video vignette. ⁶¹	Duran-Martinez M...Briceno-Delgado J	29364560	2018
49	Urothelial tumors with villous morphology: Histomorphology and role of immunohistochemistry in diagnosis. ⁶¹	Mitra S...Mandal AK	29399882	2018
50	Risk of advanced colorectal neoplasm by the proposed combined United States and United Kingdom risk stratification guidelines. ⁶¹	Park SK...Park DI	28986265	2018

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Genes for Villous Adenoma

Genes related to Villous Adenoma (0 elite genes):

(show all 20)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	GNAS	GNAS Complex Locus	Protein Coding	13.35	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	13.35	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	CDX2	Caudal Type Homeobox 2	Protein Coding	13.01	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	MUC5AC	Mucin 5AC, Oligomeric Mucus/Gel-Forming	Protein Coding	12.71	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	10767823 8536891
5	KRT20	Keratin 20	Protein Coding	12.52	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	MUC1	Mucin 1, Cell Surface Associated	Protein Coding	11.8	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
7	SST	Somatostatin	Protein Coding	10.84	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
8	BRAF	B-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	10.73	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	KLK3	Kallikrein Related Peptidase 3	Protein Coding	10.65	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
10	SLC45A3	Solute Carrier Family 45 Member 3	Protein Coding	10.36	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
11	FOLH1	Folate Hydrolase 1	Protein Coding	9.9	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
12	APC	APC Regulator Of WNT Signaling Pathway	Protein Coding	9.89	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	8012980
13	KRT8	Keratin 8	Protein Coding	9.87	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
14	ACP3	Acid Phosphatase 3	Protein Coding	6.68	GeneCards inferred via : Publications (show sections)
15	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	6.56	DISEASES inferred ¹⁵
16	CEACAM5	CEA Cell Adhesion Molecule 5	Protein Coding	6.47	DISEASES inferred ¹⁵
17	MLH1	MutL Homolog 1	Protein Coding	6.31	DISEASES inferred ¹⁵
18	TP53	Tumor Protein P53	Protein Coding	6.03	DISEASES inferred ¹⁵
19	MUC6	Mucin 6, Oligomeric Mucus/Gel-Forming	Protein Coding	6.02	DISEASES inferred ¹⁵
20	KRT7	Keratin 7	Protein Coding	6	DISEASES inferred ¹⁵

Sources

Variations for Villous Adenoma

Sources

Expression for Villous Adenoma

Search GEO for disease gene expression data for Villous Adenoma.

Sources

Pathways for Villous Adenoma

Pathways related to Villous Adenoma according to GeneCards Suite gene sharing:

(show all 35)

#	Super pathways	Score	Top Affiliating Genes
1	Beta-Adrenergic Signaling ⁶³ Show member pathways CDK5 Pathway ⁶³ Erythropoietin Pathway ⁶³ Insulin Receptor Pathway ⁶³	12.75	KRAS KLK3 HRAS GNAS BRAF
2	Development HGF signaling pathway ²³ Show member pathways Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1 ²³ Apoptosis and survival NGF signaling pathway ²³ Apoptosis and survival Role of CDK5 in neuronal death and survival ²³ Development Neurotrophin family signaling ²³ MET activates PTPN11 ⁶⁵ MET activates STAT3 ⁶⁵ Neurotrophin signaling pathway ³⁶ Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) ¹ Signaling of Hepatocyte Growth Factor Receptor ¹	12.65	TP53 KRAS HRAS BRAF APC
3	Glioma ³⁶ Show member pathways Endocrine resistance ³⁶ Melanoma ³⁶ Non-small cell lung cancer ³⁶ Signaling Pathways in Glioblastoma ¹	12.61	TP53 KRAS HRAS GNAS BRAF
4	Endometrial cancer ³⁶ Show member pathways Acute myeloid leukemia ³⁶ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁵ Chronic myeloid leukemia ³⁶ Colorectal cancer ³⁶ Pancreatic cancer ³⁶ Prostate cancer ³⁶ Signal transduction PTEN pathway ²³ Thyroid cancer ³⁶	12.61	TP53 MLH1 KRAS KLK3 HRAS BRAF
5	Relaxin signaling pathway ³⁶ Show member pathways Estrogen signaling pathway ³⁶ Growth hormone synthesis, secretion and action ³⁶ Relaxin receptors ⁶⁵	12.6	SST KRT20 KRAS HRAS GNAS
6	Gastric cancer ³⁶ Show member pathways Breast cancer ³⁶ Hepatocellular carcinoma ³⁶	12.47	TP53 MLH1 KRAS HRAS CDX2 BRAF
7	MicroRNAs in cancer ³⁶	12.44	TP53 SLC45A3 KRAS HRAS APC
8	mTOR signaling pathway (KEGG) ³⁶ Show member pathways mTOR Signaling Pathway ⁶⁴	12.4	TP53 KRAS HRAS BRAF APC
9	Pathways in cancer ³⁶	12.28	TP53 MLH1 KRAS KLK3 HRAS GNAS
10	Development ERBB-family signaling ²³ Show member pathways Development EGFR signaling pathway ²³ EGF Pathway ⁶³ ErbB receptor signaling network ¹ GRB7 events in ERBB2 signaling ⁶⁵ PLCG1 events in ERBB2 signaling ⁶⁵	12.26	MUC1 KRAS HRAS BRAF
11	Translation Non-genomic (rapid) action of Androgen Receptor ²³ Show member pathways Basal cell carcinoma ³⁶ Transcription Androgen Receptor nuclear signaling ²³	12.25	TP53 KLK3 HRAS APC
12	Proteoglycans in cancer ³⁶	12.24	TP53 KRAS HRAS BRAF
13	CLEC7A (Dectin-1) signaling ⁶⁵ Show member pathways Alternative NF-kappaB pathway ¹ CLEC7A/inflammasome pathway ⁶⁵ C-type lectin receptors (CLRs) ⁶⁵	12.24	MUC6 MUC5AC MUC1 KRAS HRAS
14	G-protein signaling Ras family GTPases in kinase cascades (scheme) ²³ Show member pathways Activation of the AP-1 family of transcription factors ⁶⁵ Immune response Oncostatin M signaling via MAPK in human cells ²³ MAPK Cascade ¹ Nanoparticle-mediated activation of receptor signaling ¹ Oncostatin M Signaling Pathway ¹	12.22	TP53 KRAS HRAS BRAF
15	mTOR Pathway ⁶⁹ Show member pathways Insulin Pathway ⁶⁹ TGF-beta Pathway ⁶⁹	12.09	TP53 KRAS HRAS BRAF
16	NGF Pathway ⁶³ Show member pathways TRKA Signaling ⁶³	12.06	TP53 KRAS HRAS BRAF
17	Serotonergic synapse ³⁶	11.86	KRAS HRAS GNAS BRAF
18	DNA Damage Response (only ATM dependent) ¹	11.84	TP53 KRAS HRAS APC
19	Long-term potentiation ³⁶ Show member pathways Common Pathways Underlying Drug Addiction ¹	11.8	KRAS HRAS GNAS BRAF
20	Gap junction ³⁶	11.79	KRAS HRAS GNAS
21	VEGF Pathway (Tocris) ⁶⁹ Show member pathways Sorafenib Pharmacodynamics ⁶⁰	11.76	KRAS HRAS BRAF
22	MAPK Signaling: Oxidative Stress Pathway ⁶⁴	11.73	TP53 KRAS BRAF
23	Commom Cytokine Receptor G Chain Siganaling Pathway ⁶⁶	11.68	KRAS HRAS BRAF
24	Central carbon metabolism in cancer ³⁶	11.67	TP53 KRAS HRAS
25	Mitophagy - animal ³⁶	11.65	TP53 KRAS HRAS
26	Human Thyroid Stimulating Hormone (TSH) signaling pathway ¹	11.65	HRAS GNAS BRAF
27	Negative regulation of MAPK pathway ⁶⁵ Show member pathways RAF activation ⁶⁵	11.62	KRAS HRAS BRAF
28	Glioblastoma Multiforme ⁶³	11.6	TP53 KRAS HRAS BRAF APC
29	Bladder cancer ³⁶ ¹	11.57	TP53 KRAS HRAS BRAF
30	Long-term depression ³⁶	11.45	KRAS HRAS GNAS BRAF
31	Vemurafenib Pathway, Pharmacodynamics ⁶⁰	11.38	KRAS HRAS BRAF
32	Colorectal Cancer Metastasis ⁶³	11.32	TP53 MLH1 KRAS GNAS BRAF APC
33	Crizotinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰	11.31	KRAS HRAS BRAF
34	BDNF-TrkB Signaling ¹	11.22	KRAS HRAS BRAF
35	Extracellular vesicle-mediated signaling in recipient cells ¹	11.16	KRAS HRAS APC

Sources

GO Terms for Villous Adenoma

Cellular components related to Villous Adenoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular exosome	GO:0070062	9.28	MUC5AC MUC1 KRT8 KRT7 KLK3 GNAS

Biological processes related to Villous Adenoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	Ras protein signal transduction	GO:0007265	9.5	TP53 KRAS HRAS
2	response to isolation stress	GO:0035900	9.26	KRAS HRAS
3	positive regulation of transcription from RNA polymerase II promoter in response to stress	GO:0036003	9.16	TP53 MUC1
4	O-glycan processing	GO:0016266	9.13	MUC6 MUC5AC MUC1
5	stimulatory C-type lectin receptor signaling pathway	GO:0002223	9.02	MUC6 MUC5AC MUC1 KRAS HRAS

Molecular functions related to Villous Adenoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:0005515	9.6	TP53 SST MUC6 MUC5AC MUC1 MLH1

Sources

Sources for Villous Adenoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Apr-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ Tocris

⁷⁰ UMLS

⁷¹ UMLS via Orphanet

⁷² UniProtKB/Swiss-Prot

⁷³ Wikipedia