MCID: VLL006
MIFTS: 40

Villous Adenoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Villous Adenoma

MalaCards integrated aliases for Villous Adenoma:

Name: Villous Adenoma 12 15
Adenoma, Villous 70
Adenoma Villous 54

Classifications:



External Ids:

Disease Ontology 12 DOID:0050869
UMLS 70 C0206674

Summaries for Villous Adenoma

Disease Ontology : 12 An adenoma that is located in the colon and other places in the gastrointestinal tract and sometimes in other parts of the body.

MalaCards based summary : Villous Adenoma, also known as adenoma, villous, is related to urethral villous adenoma and urinary bladder villous adenoma. An important gene associated with Villous Adenoma is GNAS (GNAS Complex Locus), and among its related pathways/superpathways are Beta-Adrenergic Signaling and Development HGF signaling pathway. The drugs Catechin and Epigallocatechin gallate have been mentioned in the context of this disorder. Affiliated tissues include colon, appendix and pancreas, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Villous Adenoma

Diseases related to Villous Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 514)
# Related Disease Score Top Affiliating Genes
1 urethral villous adenoma 32.2 KRT7 KRT20 CEACAM5
2 urinary bladder villous adenoma 31.0 MUC6 MUC5AC MUC1 KRT7 KRT20 CEACAM5
3 urachal adenocarcinoma 30.4 KRAS GNAS CEACAM5 BRAF
4 in situ carcinoma 30.3 TP53 MUC1 KRT8 HRAS
5 neuroendocrine carcinoma 30.1 SST MUC1 KRT7 KRT20 CEACAM5
6 urethral diverticulum 30.1 KRT7 KLK3
7 meckel diverticulum 30.1 SST KRT7 CDX2
8 appendix adenocarcinoma 30.0 KRT7 KRT20 KRAS HRAS GNAS CDX2
9 squamous cell papilloma 30.0 TP53 HRAS
10 neuroendocrine tumor 30.0 SST KRT20 HRAS CDX2
11 bladder adenocarcinoma 29.9 KRT7 KRT20 KLK3 CDX2
12 mammary paget's disease 29.9 MUC1 KRT8 KRT7 KRT20
13 adenocarcinoma in situ 29.8 KRT7 KRT20 KRAS CEACAM5 CDX2
14 bladder urothelial carcinoma 29.7 TP53 KRT20 KRAS HRAS BRAF
15 intestinal obstruction 29.7 KRT7 KRT20 CEACAM5 CDX2
16 gastrointestinal carcinoma 29.7 TP53 MUC1 KRT20 CEACAM5 CDX2
17 glandular cystitis 29.7 TP53 MUC5AC MUC1 KRT7 KRT20 CDX2
18 bile duct adenoma 29.6 TP53 MUC1 KRT7 KRT20
19 papilloma 29.6 TP53 KRT8 KRT7 KRT20 KRAS
20 colorectal adenoma 29.6 TP53 MLH1 KRAS HRAS APC
21 bile duct cysts 29.6 KRT7 KRAS HRAS CEACAM5
22 appendiceal neoplasm 29.5 KRT7 KRAS HRAS GNAS CEACAM5 CDX2
23 anal canal adenocarcinoma 29.5 MUC5AC KRT7 KRT20 CEACAM5 CDX2
24 rectum cancer 29.3 MLH1 KRT20 KRAS HRAS CEACAM5 APC
25 cholecystitis 29.2 TP53 MUC6 MUC5AC MUC1
26 familial adenomatous polyposis 29.1 TP53 MLH1 KRAS HRAS APC
27 mucoepidermoid carcinoma 29.1 TP53 MUC5AC MUC1 KRT7 CEACAM5
28 cervical adenocarcinoma 29.1 TP53 KRT7 KRT20 KRAS CEACAM5 CDX2
29 adenoma 29.1 TP53 SST MUC6 MUC5AC MUC1 MLH1
30 papillary adenoma 29.1 TP53 KRT7 KRAS HRAS CEACAM5
31 intrahepatic cholangiocarcinoma 29.1 TP53 MUC5AC MUC1 KRT7 KRT20 KRAS
32 small cell carcinoma 29.0 TP53 MUC1 KRT8 KRT7 KRT20 KRAS
33 adenosquamous carcinoma 29.0 TP53 MUC1 KRT8 KRT7 KRAS CEACAM5
34 mucinous adenocarcinoma 28.7 TP53 MUC5AC MUC1 MLH1 KRT7 KRT20
35 bladder cancer 28.6 TP53 MUC1 MLH1 KRT8 KRT20 KRAS
36 transitional cell carcinoma 28.6 TP53 MLH1 KRT8 KRT7 KRT20 KLK3
37 intestinal benign neoplasm 28.6 TP53 MLH1 KRAS HRAS CEACAM5 CDX2
38 renal cell carcinoma, nonpapillary 28.6 TP53 MUC1 KRT8 KRT7 KRT20 HRAS
39 barrett esophagus 28.4 TP53 MUC6 MUC5AC KRT7 KRT20 CDX2
40 rectum adenocarcinoma 28.3 TP53 MLH1 KRT7 KRT20 KRAS HRAS
41 adenocarcinoma 28.3 TP53 MUC1 MLH1 KRT7 KRT20 KRAS
42 duodenum adenocarcinoma 28.3 MUC6 MUC5AC MLH1 KRT7 KRAS HRAS
43 cholangiocarcinoma 28.2 TP53 MUC5AC MUC1 KRT8 KRT7 KRT20
44 gastric adenocarcinoma 28.1 TP53 MLH1 KRT20 KRAS HRAS GNAS
45 pseudomyxoma peritonei 27.8 TP53 MUC6 MUC5AC MUC1 KRT7 KRT20
46 colorectal adenocarcinoma 27.7 TP53 MUC1 MLH1 KRT7 KRT20 KRAS
47 signet ring cell adenocarcinoma 27.4 TP53 MUC6 MUC5AC MUC1 MLH1 KRT7
48 duodenum cancer 27.4 TP53 SST MUC6 MUC5AC MUC1 MLH1
49 lung cancer susceptibility 3 27.2 TP53 MUC5AC MUC1 MLH1 KRT7 KRT20
50 bile duct cancer 26.9 TP53 MUC6 MUC5AC MUC1 MLH1 KRT7

Graphical network of the top 20 diseases related to Villous Adenoma:



Diseases related to Villous Adenoma

Symptoms & Phenotypes for Villous Adenoma

GenomeRNAi Phenotypes related to Villous Adenoma according to GeneCards Suite gene sharing:

26 (show all 34)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-1 10 BRAF HRAS KRAS MUC1
2 Decreased viability GR00055-A-2 10 BRAF HRAS KRAS MUC1
3 Decreased viability GR00055-A-3 10 KRAS
4 Decreased viability GR00106-A-0 10 KRAS
5 Decreased viability GR00221-A-1 10 HRAS KRAS
6 Decreased viability GR00221-A-2 10 HRAS KRAS
7 Decreased viability GR00221-A-3 10 HRAS
8 Decreased viability GR00221-A-4 10 BRAF
9 Decreased viability GR00249-S 10 BRAF MUC1
10 Decreased viability GR00301-A 10 BRAF KRAS
11 Decreased viability GR00381-A-1 10 BRAF KRAS
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-177 9.76 APC
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-29 9.76 APC
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-49 9.76 APC
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-6 9.76 KRT8
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.76 KRT7 KRT8
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.76 APC
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-74 9.76 APC
19 Increased shRNA abundance (Z-score > 2) GR00366-A-1 9.62 MLH1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-124 9.62 MLH1
21 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.62 KRT8
22 Increased shRNA abundance (Z-score > 2) GR00366-A-133 9.62 APC
23 Increased shRNA abundance (Z-score > 2) GR00366-A-135 9.62 KRT7 KRT8
24 Increased shRNA abundance (Z-score > 2) GR00366-A-180 9.62 KRT8
25 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.62 APC KRT7 KRT8
26 Increased shRNA abundance (Z-score > 2) GR00366-A-195 9.62 MLH1
27 Increased shRNA abundance (Z-score > 2) GR00366-A-200 9.62 MLH1
28 Increased shRNA abundance (Z-score > 2) GR00366-A-202 9.62 APC
29 Increased shRNA abundance (Z-score > 2) GR00366-A-40 9.62 KRT8
30 Increased shRNA abundance (Z-score > 2) GR00366-A-68 9.62 KRT7
31 Increased shRNA abundance (Z-score > 2) GR00366-A-72 9.62 KRT7
32 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.62 KRT7 KRT8
33 Increased shRNA abundance (Z-score > 2) GR00366-A-78 9.62 MLH1
34 Increased shRNA abundance (Z-score > 2) GR00366-A-91 9.62 KRT7

MGI Mouse Phenotypes related to Villous Adenoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.85 APC BRAF CDX2 HRAS KRAS KRT8
2 neoplasm MP:0002006 9.61 ACP3 APC BRAF CDX2 GNAS HRAS
3 normal MP:0002873 9.28 APC BRAF CDX2 GNAS HRAS KLK3

Drugs & Therapeutics for Villous Adenoma

Drugs for Villous Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Catechin Approved, Withdrawn Phase 2 154-23-4 9064
2
Epigallocatechin gallate Investigational Phase 2 989-51-5 65064
3
Epigallocatechin Experimental, Investigational Phase 2 970-74-1 72277
4
Epicatechin Investigational Phase 2 490-46-0 72276
5 Cola Phase 2
6 Tea Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Minimizing the Risk of Metachronous Adenomas of the Colorectum With Green Tea Extract -MIRACLE- Completed NCT01360320 Phase 2
2 Outcomes of Endoscopic Resection of Mucosal and Submucosal Lesions in the Duodenum and Ampulla Recruiting NCT02306603
3 Outcomes of Endoscopic Resection in the Upper Gastrointestinal Tract Recruiting NCT02305290
4 Outcomes of Endoscopic Resection of Mucosal and Submucosal Lesions in the Stomach. Recruiting NCT02306707

Search NIH Clinical Center for Villous Adenoma

Genetic Tests for Villous Adenoma

Anatomical Context for Villous Adenoma

The Foundational Model of Anatomy Ontology organs/tissues related to Villous Adenoma:

19
Colon

MalaCards organs/tissues related to Villous Adenoma:

40
Colon, Appendix, Pancreas, Kidney, Prostate, Lymph Node, Small Intestine

Publications for Villous Adenoma

Articles related to Villous Adenoma:

(show top 50) (show all 988)
# Title Authors PMID Year
1
Aberrant expression of a human mucin gene (MUC5AC) in rectosigmoid villous adenoma. 54 61
8536891 1996
2
Differential Expression Profiles of Mitogenome Associated MicroRNAs Among Colorectal Adenomatous Polyps. 61
33628862 2021
3
Molecular profiling of appendiceal serrated lesions, polyps and mucinous neoplasms: a single-centre experience. 61
33712927 2021
4
Telomerase reverse transcriptase (TERT) promoter mutations in primary adenocarcinoma of bladder and urothelial carcinoma with glandular differentiation: pathogenesis and diagnostic implications. 61
33674765 2021
5
Villous adenoma of the urethra. 61
33678969 2021
6
Giant Villous Adenoma: A Rare Case of Colorectal Adenoma that Mimic Colorectal Cancer. 61
33397878 2021
7
Giant villous adenoma of the sigmoid colon: an unusual cause of homogeneous, segmental bowel wall thickening. 61
33299583 2020
8
Non-conventional dysplasia in inflammatory bowel disease is more frequently associated with advanced neoplasia and aneuploidy than conventional dysplasia. 61
33155325 2020
9
Reliability in villous tumors staging between preoperative MRI and histopathological examination. 61
32123949 2020
10
Transanal minimally invasive surgery (TAMIS) for rectal tumor: a case report and literature review. 61
33145320 2020
11
Villous adenoma of the urachus obscuring urachal adenocarcinoma: A case report. 61
32477881 2020
12
Molecular Genetic Features of Primary Nonurachal Enteric-type Adenocarcinoma, Urachal Adenocarcinoma, Mucinous Adenocarcinoma, and Intestinal Metaplasia/Adenoma: Review of the Literature and Next-generation Sequencing Study. 61
32520749 2020
13
Villous Adenoma Arising in the Urethra of a Female with Bladder Augmentation History: A Case Report and Review of the Literature. 61
32779155 2020
14
Adult duodenal intussusception with horizontal adenoma: A rare case report. 61
32874987 2020
15
A rare case of huge villous adenoma of the renal pelvis deforming the abdominal wall. 61
32309146 2020
16
Colonoscopy in patients with psoriasis before the initiation of treatment with biological agents. 61
32506694 2020
17
Nomograms that predict the survival of patients with adenocarcinoma in villous adenoma of the colorectum: a SEER-based study. 61
32600342 2020
18
Lessons of the month 2: McKittrick-Wheelock syndrome: Case report of a patient declining resection of a large villous adenoma. 61
32414717 2020
19
Endoscopic resection of a prolapsing giant villous adenoma of the supraanal rectum. 61
31447294 2020
20
Evaluation of a Deep Neural Network for Automated Classification of Colorectal Polyps on Histopathologic Slides. 61
32324237 2020
21
Villous Morphology in Urinary Bladder Biopsy: An Approach to Diagnosis. 61
31409167 2020
22
Endocytoscopic Observation of Non-Ampullary Mucosal Duodenal Cancer. 61
32355485 2020
23
A histopathological rarity: Primary signet ring cell carcinoma arising within a colonic villous adenoma. 61
32031145 2020
24
Urinary tract villous adenoma in Indonesia. 61
31687348 2019
25
Effect of Supplementation With Marine ω-3 Fatty Acid on Risk of Colorectal Adenomas and Serrated Polyps in the US General Population: A Prespecified Ancillary Study of a Randomized Clinical Trial. 61
31750855 2019
26
Intussusception in the Setting of Tuberous Sclerosis Complex. 61
31832470 2019
27
Laparoscopic Pancreas-Sparing Duodenectomy with Roux en Y Reconstruction for Duodenal Polyposis. 61
31511136 2019
28
Giant villous adenoma of rectum- what is the malignant potential and what is the optimal treatment? A case and review of literature. 61
31238922 2019
29
Villous Adenoma Arising in the Native Bladder Mucosa and the Upper Urinary Tract With Coexisting Neuroendocrine Carcinoma Following Augmentation Cystoplasty. 61
30701999 2019
30
Villous adenoma coexistent with focal well-differentiated adenocarcinoma of female urethral orifice: A case report and review of literature. 61
31024961 2019
31
Recurrence of adenoma after curative endoscopic submucosal dissection for a rectal intramucosal adenocarcinoma in adenoma. 61
30993167 2019
32
A Rare Case of Acute Kidney Injury: McKittrick Wheelock Syndrome. 61
30988251 2019
33
Photodynamic therapy as salvage therapy for residual microscopic cancer after ultra-low anterior resection: A case report. 61
30968047 2019
34
Cancer risk in microscopic colitis: a retrospective cohort study. 61
30611218 2019
35
Tubulo-villous adenoma of the appendix: A case report and review of the literature. 61
31349156 2019
36
[A case of rectal villous adenoma with electrolyte depletion syndrome treated with surgical resection]. 61
31292319 2019
37
McKittrick-Wheelock Syndrome Presenting with Acute Kidney Injury and Metabolic Alkalosis: Case Report and Narrative Review. 61
30838142 2019
38
Precursor lesions of the urinary bladder. 61
30565304 2019
39
Is magnetic resonance imaging useful for the management of patients with rectal villous adenoma? A study of 45 consecutive patients treated by transanal endoscopic microsurgery. 61
30136172 2018
40
Should asymptomatic young men with iron deficiency anemia necessarily undergo endoscopy? 61
29294595 2018
41
[Risk analysis of the canceration of colorectal large polyps]. 61
30370516 2018
42
Villous adenoma of the choledocho: an infrequent pathology of the main bile duct. 61
30286605 2018
43
A systematic review of McKittrick-Wheelock syndrome. 61
30322287 2018
44
Intestinal-type adenocarcinoma of the vagina: clinico-pathologic features of a common tumor with a rare localization. 61
30546144 2018
45
Analysis of Syndecan-2 Methylation in Bowel Lavage Fluid for the Detection of Colorectal Neoplasm. 61
29730903 2018
46
Robotic approach to resection of villous adenoma of the urachus: a case report and literature review. 61
28889213 2018
47
Colonoscopy conversion after flexible sigmoidoscopy screening: results from the UK Bowel Scope Screening Programme. 61
29205835 2018
48
Endoanal resection of a giant villous adenoma in the middle rectum - a video vignette. 61
29364560 2018
49
Urothelial tumors with villous morphology: Histomorphology and role of immunohistochemistry in diagnosis. 61
29399882 2018
50
Risk of advanced colorectal neoplasm by the proposed combined United States and United Kingdom risk stratification guidelines. 61
28986265 2018

Variations for Villous Adenoma

Expression for Villous Adenoma

Search GEO for disease gene expression data for Villous Adenoma.

Pathways for Villous Adenoma

Pathways related to Villous Adenoma according to GeneCards Suite gene sharing:

(show all 35)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.75 KRAS KLK3 HRAS GNAS BRAF
2
Show member pathways
12.65 TP53 KRAS HRAS BRAF APC
3
Show member pathways
12.61 TP53 KRAS HRAS GNAS BRAF
4
Show member pathways
12.61 TP53 MLH1 KRAS KLK3 HRAS BRAF
5
Show member pathways
12.6 SST KRT20 KRAS HRAS GNAS
6
Show member pathways
12.47 TP53 MLH1 KRAS HRAS CDX2 BRAF
7 12.44 TP53 SLC45A3 KRAS HRAS APC
8
Show member pathways
12.4 TP53 KRAS HRAS BRAF APC
9 12.28 TP53 MLH1 KRAS KLK3 HRAS GNAS
10
Show member pathways
12.26 MUC1 KRAS HRAS BRAF
11
Show member pathways
12.25 TP53 KLK3 HRAS APC
12 12.24 TP53 KRAS HRAS BRAF
13
Show member pathways
12.24 MUC6 MUC5AC MUC1 KRAS HRAS
14
Show member pathways
12.22 TP53 KRAS HRAS BRAF
15
Show member pathways
12.09 TP53 KRAS HRAS BRAF
16
Show member pathways
12.06 TP53 KRAS HRAS BRAF
17 11.86 KRAS HRAS GNAS BRAF
18 11.84 TP53 KRAS HRAS APC
19
Show member pathways
11.8 KRAS HRAS GNAS BRAF
20 11.79 KRAS HRAS GNAS
21
Show member pathways
11.76 KRAS HRAS BRAF
22 11.73 TP53 KRAS BRAF
23 11.68 KRAS HRAS BRAF
24 11.67 TP53 KRAS HRAS
25 11.65 TP53 KRAS HRAS
26 11.65 HRAS GNAS BRAF
27
Show member pathways
11.62 KRAS HRAS BRAF
28 11.6 TP53 KRAS HRAS BRAF APC
29 11.57 TP53 KRAS HRAS BRAF
30 11.45 KRAS HRAS GNAS BRAF
31 11.38 KRAS HRAS BRAF
32 11.32 TP53 MLH1 KRAS GNAS BRAF APC
33 11.31 KRAS HRAS BRAF
34 11.22 KRAS HRAS BRAF
35 11.16 KRAS HRAS APC

GO Terms for Villous Adenoma

Cellular components related to Villous Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.28 MUC5AC MUC1 KRT8 KRT7 KLK3 GNAS

Biological processes related to Villous Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Ras protein signal transduction GO:0007265 9.5 TP53 KRAS HRAS
2 response to isolation stress GO:0035900 9.26 KRAS HRAS
3 positive regulation of transcription from RNA polymerase II promoter in response to stress GO:0036003 9.16 TP53 MUC1
4 O-glycan processing GO:0016266 9.13 MUC6 MUC5AC MUC1
5 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.02 MUC6 MUC5AC MUC1 KRAS HRAS

Molecular functions related to Villous Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.6 TP53 SST MUC6 MUC5AC MUC1 MLH1

Sources for Villous Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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