MCID: VRL007
MIFTS: 51

Viral Encephalitis

Categories: Immune diseases, Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Viral Encephalitis

MalaCards integrated aliases for Viral Encephalitis:

Name: Viral Encephalitis 12 15 17 71
Epidemic Encephalitis 12 74
Encephalitis, Arbovirus 43
Arbovirus Encephalitis 71
Encephalitis Viral 54

Classifications:



External Ids:

Disease Ontology 12 DOID:646
MeSH 43 D004671
NCIt 49 C34576
SNOMED-CT 67 20411005 68197003
ICD10 32 A85.8 A86
UMLS 71 C0014055 C0243010

Summaries for Viral Encephalitis

Disease Ontology : 12 An encephalitis that involves inflammation of the brain caused by viral infection.

MalaCards based summary : Viral Encephalitis, also known as epidemic encephalitis, is related to japanese encephalitis and cerebral palsy. An important gene associated with Viral Encephalitis is VCAM1 (Vascular Cell Adhesion Molecule 1), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Dexamethasone acetate and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include brain, t cells and bone, and related phenotypes are hematopoietic system and immune system

Wikipedia : 74 Encephalitis is inflammation of the brain. Severity is variable. Symptoms may include headache, fever,... more...

Related Diseases for Viral Encephalitis

Diseases in the Encephalitis family:

Viral Encephalitis Autoimmune Encephalitis
Chronic Encephalitis Infectious Encephalitis

Diseases related to Viral Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 796)
# Related Disease Score Top Affiliating Genes
1 japanese encephalitis 32.3 TNF CXCL10 CCL5 CCL2
2 cerebral palsy 31.8 TNF PTGS2 IL6 IL1B IL10 CXCL8
3 rabies 31.0 MX1 CXCL10 CD40LG CCL5
4 measles 30.7 TNF IL6 IL1B CD40LG CCL5
5 neurosyphilis 30.6 IL10 CXCL8 CXCL10
6 intracranial hypertension 30.5 TNF IL1B CXCL10
7 thyroiditis 30.5 TNF IL6 IL10
8 acute transverse myelitis 30.4 IL6 IL10 CXCL8
9 poliomyelitis 30.3 TNF IL10 CD8A CD40LG
10 acute myocarditis 30.3 IL6 IL10 CD8A
11 mumps 30.2 TNF MX1 IL6 IL10 CXCL8 CXCL10
12 hepatitis a 30.2 TNF IL10 CXCL10
13 subacute sclerosing panencephalitis 30.2 TNF MX1 MOG MBP IL6 IL10
14 retinal vasculitis 30.2 CD40LG CCR6 CCL2
15 encephalomalacia 30.2 MBP IL6 IL1B
16 graft-versus-host disease 30.2 TNF IL6 IL1B IL10
17 tuberculous meningitis 30.1 VEGFA TNF CXCL8 CCL2
18 pulmonary edema 30.1 TNF IL1B IL10 CXCL8
19 bacterial meningitis 30.1 TNF IL6 IL1B IL10 CXCL8 CCL2
20 carotid stenosis 30.1 VEGFA VCAM1 TNF CXCL8
21 rubella 30.1 TNF MOG IL6 IL10 CD40LG
22 allergic encephalomyelitis 30.1 MOG MBP CCL5 CCL2
23 toxic encephalopathy 30.1 TNF PTGS2 IL6 IL1B
24 viral meningitis 30.1 IL6 CXCL8 CXCL10 CD40LG CCL5 CCL2
25 chikungunya 30.0 TNF IL6 IL1B CCL5 CCL2
26 stomatitis 30.0 TNF MX1 IL6 IL1B IL10 CXCL8
27 mouth disease 30.0 MX1 IL6 IL1B IL10 CCR6
28 plague 30.0 TNF IL6 IL10 CD8A
29 chickenpox 29.9 TNF IL6 IL10 CD8A CD40LG CCR6
30 plasmodium falciparum malaria 29.9 TNF IL6 IL10 CD40LG
31 lyme disease 29.9 TNF IL6 IL1B CD40LG
32 syphilis 29.9 CD8A CD40LG CCR6
33 retinal detachment 29.9 VEGFA TNF IL6 CXCL8 CCL2
34 myasthenia gravis 29.9 TNFSF13B TNF MBP IL10
35 aseptic meningitis 29.9 TNF IL1B IL10 CXCL8 CD40LG
36 choroiditis 29.9 VEGFA TNF IL10 CD40LG
37 transverse myelitis 29.8 TNF MBP IL6 IL10 CXCL8
38 vasculitis 29.8 VCAM1 TNFSF13B TNF IL6 CD40LG CCL2
39 ehrlichiosis 29.8 IL10 CD8A CD40LG
40 viral hepatitis 29.8 TNF MX1 IL6 IL10 CD40LG
41 cerebrovascular disease 29.8 VCAM1 TNF IL6 CD40LG
42 encephalitis 29.8 VCAM1 TNF MX1 MOG LGI1 IL6
43 guillain-barre syndrome 29.8 TNF MOG MBP CD40LG
44 respiratory failure 29.8 TNF IL6 IL1B IL10 CXCL8 CXCL10
45 influenza 29.7 TNF MX1 IL6 IL1B CXCL8 CXCL10
46 brucellosis 29.7 TNF IL6 IL10 CXCL8 CD40LG
47 toxoplasmosis 29.7 TNF IL6 IL1B IL10 CD40LG
48 kidney disease 29.7 VEGFA VCAM1 TNF IL6 CCL5 CCL2
49 myocarditis 29.6 VCAM1 TNF IL6 IL1B IL10 CD40LG
50 spotted fever 29.6 TNF IL10 CXCL9 CXCL10 CD40LG CCL5

Graphical network of the top 20 diseases related to Viral Encephalitis:



Diseases related to Viral Encephalitis

Symptoms & Phenotypes for Viral Encephalitis

MGI Mouse Phenotypes related to Viral Encephalitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.13 CCL5 CCR6 CD40LG CD8A CXCL10 IL10
2 immune system MP:0005387 10.06 CCL2 CCL5 CCR6 CD40LG CD8A CXCL10
3 cardiovascular system MP:0005385 10.02 CCR6 CD40LG CXCL10 IL10 IL1B IL6
4 integument MP:0010771 9.61 CD40LG CD8A IL10 IL1B IL6 LGI1
5 nervous system MP:0003631 9.44 CCR6 CD40LG CD8A CXCL10 IL10 IL1B

Drugs & Therapeutics for Viral Encephalitis

Drugs for Viral Encephalitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
2
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
3
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
4
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
5
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
6 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
7
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
8
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
9 Gastrointestinal Agents Phase 4
10 Methylprednisolone Acetate Phase 4
11 Autonomic Agents Phase 4
12 Hormone Antagonists Phase 4
13 Neuroprotective Agents Phase 4
14 Protective Agents Phase 4
15 Anti-Inflammatory Agents Phase 4
16 BB 1101 Phase 4
17 Antineoplastic Agents, Hormonal Phase 4
18 glucocorticoids Phase 4
19 Hormones Phase 4
20 Antiemetics Phase 4
21
Ribavirin Approved Phase 2 36791-04-5 37542
22 Antiviral Agents Phase 2
23 Antimetabolites Phase 2
24 Anti-Infective Agents Phase 2
25 Immunoglobulins Phase 2
26 Antibodies Phase 2
27 Rho(D) Immune Globulin Phase 2
28 Immunoglobulins, Intravenous Phase 2
29 gamma-Globulins Phase 2
30
Aluminum hydroxide Approved, Investigational Phase 1 21645-51-2
31 Vaccines Phase 1
32 Immunologic Factors Phase 1

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Low Dose Versus High Dose Steroids in Treatment of Viral Encephalitis Not yet recruiting NCT04103684 Phase 4 Methylprednisolone;Dexamethasone
2 Assessment of the Non-Inferiority of the Concurrent Administration of Japanese Encephalitis Live Attenuated SA 14-14-2 Vaccine and Measles Vaccine Given Alone Completed NCT00249769 Phase 3
3 Long-Term Assessment at 24 Months Post-Vaccination of the Non-Inferiority of the Concurrent Administration of Japanese Encephalitis Live Attenuated SA 14-14-2 Vaccine and Measles Vaccine to Measles Vaccine Given Alone Completed NCT00412516 Phase 3
4 A Single-centre Phase III Clinical Trial for Vero Cell-derived Inactivated Japanese Encephalitis Vaccine Produced by Shandong Hengye Biotech Co., Ltd. in Healthy Chinese Infants Aged 6-11 Months, Aimed to Evaluate Immunogenicity and Safety Completed NCT02367664 Phase 3
5 Assessment of the Immunogenicity and Safety of Japanese Encephalitis Live Attenuated SA 14-14-2 Vaccine in Children in Sri Lanka Completed NCT00463476 Phase 3
6 Immunogenicity and Safety of Inactivated Vero Cell Derived Japanese Encephalitis Vaccine in Thai Children Completed NCT01408537 Phase 3
7 Treatment of Japanese Encephalitis - a Double Blind Placebo Controlled Trial Unknown status NCT00216268 Phase 2 Ribavirin
8 A Randomized Double Blind Placebo Controlled Trial to Assess the Safety and Efficacy of Intravenous Immunoglobulin (IVIG) in Children With Japanese Encephalitis in Nepal Completed NCT01856205 Phase 2 Intravenous immunoglobulin [ImmunoRel™ (batch 20081217)]
9 Phase II Study Assessing the Effect of BK Specific CTL Lines Generated by Ex Vivo Expansion in Patients With BK Virus Infection and JC Virus Infection Recruiting NCT02479698 Phase 2
10 A Phase 2 Open-Label, Safety and Immunogenicity Study of Venezuelan Equine Encephalomyelitis Vaccine, Inactivated, Dried, C-84, TSI-GSD 205 When Used as a Booster After TC-83 Primary Immunization in Healthy Adults At-Risk for Exposure to Virulent Venezuelan Equine Encephalomyelitis Virus Active, not recruiting NCT00582088 Phase 2
11 Phase 1 Study of the Safety and Immunogenicity of a 2-Dose Regimen of West Nile/Dengue 4-3´Δ30 Chimeric Virus Vaccine (WN/DEN4Δ30), a Live Attenuated Vaccine for West Nile Encephalitis, in Flavivirus-naïve Adults 50-65 Years of Age Completed NCT02186626 Phase 1
12 A Phase 1 Dose Escalation Study to Assess the Safety and Immunogenicity of a Monovalent Virus-Like Particle (VLP) Venezuelan Equine Encephalitis Vaccine in Healthy Adults Recruiting NCT03776994 Phase 1
13 Singapore Neurologic Infections Program Unknown status NCT02017665
14 Management of Acute Disseminated Encephalomyelitis in Neurology Unit of Assiut University Children Hospital Unknown status NCT03284801
15 Cerebrospinal Fluid Polymerase Chain Reaction Arrays for Central Nervous System Neurotropic Viral Infection and Mycobacterium Infection Study Completed NCT00807378
16 Paediatric Infections Point-Of-Care: Point-of-care Approach for Rapid and Easy Meningitis Diagnosis Not yet recruiting NCT03900091

Search NIH Clinical Center for Viral Encephalitis

Cochrane evidence based reviews: encephalitis, arbovirus

Genetic Tests for Viral Encephalitis

Anatomical Context for Viral Encephalitis

MalaCards organs/tissues related to Viral Encephalitis:

40
Brain, T Cells, Bone, B Cells, Kidney, Monocytes, Liver

Publications for Viral Encephalitis

Articles related to Viral Encephalitis:

(show top 50) (show all 1956)
# Title Authors PMID Year
1
[Changes and roles of VEGF and VCAM-1 in cerebrospinal fluid of children with viral encephalitis]. 54 61
18554449 2008
2
Immunohistochemical evaluation of mx protein expression in canine encephalitides. 54 61
17099155 2006
3
Characteristic abnormalities in cerebrospinal fluid biochemistry in children with cerebral malaria compared to viral encephalitis. 54 61
16764711 2006
4
Expression of the interferon-induced MxA protein in viral encephalitis. 54 61
12787324 2003
5
Antibody responses to Acinetobacter spp. and Pseudomonas aeruginosa in multiple sclerosis: prospects for diagnosis using the myelin-acinetobacter-neurofilament antibody index. 54 61
11687461 2001
6
Intravenous immunoglobulin therapy in acute disseminated encephalomyelitis. 54 61
10465150 1999
7
Computational Identification of Natural Product Leads that Inhibit Mast Cell Chymase: An Exclusive Plausible Treatment for Japanese Encephalitis. 61
32036760 2020
8
Three-year surveillance of culicine mosquitoes (Diptera: Culicidae) for flavivirus infections in Incheon Metropolitan City and Hwaseong-si of Gyeonggi-do Province, Republic of Korea. 61
31733189 2020
9
Clinical and Diagnostic Evaluation in Case of Viral Encephalitis. 61
31979627 2020
10
Human encephalitis caused by pseudorabies virus infection: a case report. 61
31898060 2020
11
Parainfluenza Virus 5 Infection in Neurological Disease and Encephalitis of Cattle. 61
31941046 2020
12
Cytokine characteristic of cerebrospinal fluid from children with enteroviral meningitis compared to bacterial meningitis. 61
31912935 2020
13
Clinical, laboratory and immune aspects of Zika virus-associated encephalitis in children. 61
31678190 2020
14
West Nile virus capsid protein inhibits autophagy by AMP-activated protein kinase degradation in neurological disease development. 61
31971978 2020
15
Development and validation of a multiplex-PCR based assay for the detection of 18 pathogens in the cerebrospinal fluid of hospitalized children with viral encephalitis. 61
31863863 2019
16
Viral Equine Encephalitis, a Growing Threat to the Horse Population in Europe? 61
31878129 2019
17
Treatable causes of adult-onset rapid cognitive impairment. 61
31715517 2019
18
Enterovirus pathogenesis requires the host methyltransferase SETD3. 61
31527793 2019
19
Cellular microRNA-155 Regulates Virus-Induced Inflammatory Response and Protects against Lethal West Nile Virus Infection. 61
31861621 2019
20
Determining the clinical characteristics and prognostic factors for the outcomes of Japanese encephalitis in adults: A multicenter study from southern Taiwan. 61
31628089 2019
21
Human encephalitis complicated with bilateral acute retinal necrosis associated with pseudorabies virus infection: A case report. 61
31562933 2019
22
Reduction patterns of Japanese encephalitis incidence following vaccine introduction into long-term expanded program on immunization in Yunnan Province, China. 61
31818328 2019
23
Vector Mosquito Ecology and Japanese Encephalitis Virus Genotype III Strain Detection from Culex tritaeniorhynchus and Pig in Huaihua, China. 61
31184992 2019
24
Host CARD11 Inhibits Newcastle Disease Virus Replication by Suppressing Viral Polymerase Activity in Neurons. 61
31554683 2019
25
Reversible lesion in the splenium of the corpus callosum. 61
31588684 2019
26
Dengue infection in mice inoculated by the intracerebral route: neuropathological effects and identification of target cells for virus replication. 61
31784616 2019
27
Japanese encephalitis virus: Associated immune response and recent progress in vaccine development. 61
31437579 2019
28
Chronic post-encephalitic epilepsy following Japanese encephalitis: Clinical features, neuroimaging data, and outcomes. 61
31600677 2019
29
The immunobiology of autoimmune encephalitides. 61
31611142 2019
30
West Nile Virus Induced Cell Death in the Central Nervous System. 61
31683807 2019
31
Twenty years of West Nile virus spread and evolution in the Americas visualized by Nextstrain. 61
31671157 2019
32
Analysis of cross-reactivity between flaviviruses with sera of patients with Japanese encephalitis showed the importance of neutralization tests for the diagnosis of Japanese encephalitis. 61
31105002 2019
33
PD1+CCR2+CD8+ T Cells Infiltrate the Central Nervous System during Acute Japanese Encephalitis Virus Infection. 61
31215000 2019
34
Upregulated expression of the antioxidant sestrin 2 identified by transcriptomic analysis of Japanese encephalitis virus-infected SH-SY5Y neuroblastoma cells. 61
31292858 2019
35
Multiple Factors Including Infections and Antibiotics Affecting New-Onset Epilepsy in Hemodialysis Patients. 61
30673174 2019
36
Centenary of Tretiakoff's thesis on the morphology of Parkinson's disease, evolved on the grounds of encephalitis lethargica pathology. 61
31226240 2019
37
Simply influenza A (H3N2)-associated encephalitis with seizure. 61
31230923 2019
38
Parkinsonism Caused by Viral Encephalitis Affecting the Bilateral Substantia Nigra. 61
30796493 2019
39
Correction to: Ventral striatal and septal area hypermetabolism on FDG-PET in herpes simplex viral encephalitis. 61
31515701 2019
40
Viral encephalitis: a practical review on diagnostic approach and treatment. 61
31513761 2019
41
Gamma Interferon Alters Junctional Integrity via Rho Kinase, Resulting in Blood-Brain Barrier Leakage in Experimental Viral Encephalitis. 61
31387911 2019
42
Herpes simplex reactivation following neurosurgery: case report and review of the literature. 61
31370030 2019
43
Two Years of Viral Metagenomics in a Tertiary Diagnostics Unit: Evaluation of the First 105 Cases. 61
31470675 2019
44
Diagnostic value of specific antibody synthesis in brain of patients with neuroinfections 61
31999907 2019
45
Pathogenicity comparison of duck Tembusu virus in different aged Cherry Valley breeding ducks. 61
31387589 2019
46
T cells promote microglia-mediated synaptic elimination and cognitive dysfunction during recovery from neuropathogenic flaviviruses. 61
31235930 2019
47
Fulminant bilateral acute retinal necrosis complicated with secondary herpes simplex type-1 viral encephalitis: A case report. 61
31464954 2019
48
[Epidemiological and spatial-temporal distribution of several natural focus diseases in Gansu province, 2014-2018]. 61
31484259 2019
49
Spectrum and Immediate Outcome of Acute Kidney Injury in a Pediatric Intensive Care Unit: A Snapshot Study from Indian Subcontinent. 61
31485103 2019
50
Deep brain stimulation of the anterior nucleus of the thalamus in a patient with super-refractory convulsive status epilepticus. 61
31403465 2019

Variations for Viral Encephalitis

Expression for Viral Encephalitis

Search GEO for disease gene expression data for Viral Encephalitis.

Pathways for Viral Encephalitis

Pathways related to Viral Encephalitis according to GeneCards Suite gene sharing:

(show top 50) (show all 75)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.1 VEGFA VCAM1 TNFSF13B TNF PTGS2 MX1
2
Show member pathways
13.9 VEGFA TNFSF13B TNF PTGS2 IL6 IL1B
3
Show member pathways
13.78 TNFSF13B TNF PTGS2 IL6 IL1B IL10
4
Show member pathways
13.62 VEGFA TNFSF13B TNF IL6 IL1B IL10
5
Show member pathways
13.5 TNFSF13B TNF IL6 IL1B IL10 CXCL9
6
Show member pathways
13.48 VEGFA VCAM1 CXCL9 CXCL8 CXCL10 CCR6
7
Show member pathways
13.43 VEGFA VCAM1 TNFSF13B TNF PTGS2 MX1
8
Show member pathways
13.4 TNFSF13B TNF IL6 IL1B IL10 CXCL9
9
Show member pathways
13.24 TNF MX1 IL6 IL1B IL10 CXCL9
10
Show member pathways
13.06 VEGFA TNF PTGS2 IL6 IL1B CXCL8
11
Show member pathways
12.99 VEGFA TNFSF13B TNF IL6 IL1B IL10
12
Show member pathways
12.97 CXCL9 CXCL8 CXCL10 CCR6 CCL5 CCL2
13
Show member pathways
12.95 TNF MX1 IL6 IL1B CXCL8 CXCL10
14
Show member pathways
12.86 TNF IL6 IL1B CXCL8 CXCL10 CCL5
15 12.84 TNF IL6 IL1B CCL5 CCL2
16
Show member pathways
12.76 TNFSF13B TNF IL6 IL1B CD40LG
17
Show member pathways
12.72 TNF IL6 IL1B IL10 CD8A CD40LG
18
Show member pathways
12.7 TNF IL6 IL1B IL10 CXCL9 CCL2
19 12.62 VCAM1 TNFSF13B TNF PTGS2 IL1B IL10
20
Show member pathways
12.48 TNF PTGS2 IL6 IL1B CCL5 CCL2
21
Show member pathways
12.48 TNF PTGS2 IL6 IL1B CXCL8 CXCL10
22
Show member pathways
12.48 TNF IL6 IL10 CXCL9 CXCL8 CXCL10
23 12.42 TNF IL1B CXCL8 CCL5
24
Show member pathways
12.41 TNF PTGS2 IL6 IL1B CXCL8
25 12.39 TNF IL6 IL1B CXCL8 CCL5 CCL2
26
Show member pathways
12.38 TNF PTGS2 IL1B IL10 CD40LG
27
Show member pathways
12.38 TNF MX1 IL6 IL1B IL10 CXCL8
28 12.35 TNF IL6 IL1B CXCL8
29
Show member pathways
12.34 TNF PTGS2 IL6 IL1B CXCL8
30
Show member pathways
12.33 TNF PTGS2 IL6 IL1B IL10
31 12.32 VEGFA TNF IL6 IL1B IL10 CXCL8
32 12.3 TNF IL6 IL1B IL10
33
Show member pathways
12.3 TNF IL6 IL1B CXCL8 CXCL10
34 12.26 VEGFA TNF PTGS2 IL6
35 12.22 VEGFA VCAM1 TNF IL1B CCL2
36 12.17 TNF IL6 IL1B IL10 CXCL8 CCL2
37
Show member pathways
12.14 TNF IL6 IL1B IL10
38 12.14 TNFSF13B TNF PTGS2 MBP IL6 IL1B
39 12.11 VCAM1 TNF PTGS2 IL6 IL1B CXCL10
40 12.09 VCAM1 TNFSF13B TNF PTGS2 IL1B CXCL8
41 12.08 TNF IL6 IL10 CD8A
42 12.08 TNF IL6 IL1B IL10 CXCL8
43 12.07 VEGFA VCAM1 TNF IL6 IL1B CXCL8
44 12.01 TNF IL6 IL1B CD8A
45 12 VEGFA TNFSF13B TNF IL6 IL1B CXCL8
46 11.97 VEGFA VCAM1 TNF PTGS2 IL6 IL1B
47 11.96 TNF IL1B IL10 CD8A CCR6
48 11.93 TNF IL6 IL1B IL10 CXCL8
49 11.91 TNF IL6 IL1B IL10 CD8A
50
Show member pathways
11.89 TNF PTGS2 CXCL8 CD40LG

GO Terms for Viral Encephalitis

Cellular components related to Viral Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 VEGFA TNFSF13B TNF LGI1 IL6 IL1B
2 external side of plasma membrane GO:0009897 9.76 VCAM1 TNF MOG CXCL9 CXCL10 CD8A
3 cell surface GO:0009986 9.73 VEGFA VCAM1 TNF MBP CD40LG CCR6
4 extracellular space GO:0005615 9.47 VEGFA VCAM1 TNFSF13B TNF LGI1 IL6

Biological processes related to Viral Encephalitis according to GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.25 VEGFA TNFSF13B MX1 IL6 IL1B IL10
2 negative regulation of cell proliferation GO:0008285 10.12 PTGS2 IL6 IL1B IL10 CXCL8
3 MAPK cascade GO:0000165 10.04 TNF MBP IL1B CCL5 CCL2
4 cell-cell signaling GO:0007267 10.03 IL1B CXCL9 CXCL10 CCL5
5 regulation of immune response GO:0050776 10.03 VCAM1 TNFSF13B MOG CD8A CD40LG
6 regulation of cell proliferation GO:0042127 10.02 TNF PTGS2 CXCL9 CXCL10
7 defense response to virus GO:0051607 10.01 MX1 IL6 CXCL9 CXCL10
8 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.99 TNF IL6 IL1B CD40LG
9 response to lipopolysaccharide GO:0032496 9.99 VCAM1 PTGS2 IL1B IL10 CXCL10
10 cellular response to tumor necrosis factor GO:0071356 9.98 VCAM1 CXCL8 CCL5 CCL2
11 defense response GO:0006952 9.97 TNF MX1 CXCL9 CXCL8 CXCL10
12 positive regulation of DNA-binding transcription factor activity GO:0051091 9.96 TNF IL6 IL1B IL10
13 response to virus GO:0009615 9.95 TNF MX1 CXCL10 CCL5
14 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.93 VEGFA TNF PTGS2 IL6
15 chemotaxis GO:0006935 9.93 CXCL9 CXCL8 CXCL10 CCR6 CCL5 CCL2
16 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.92 VEGFA TNF IL6 CCL5
17 B cell differentiation GO:0030183 9.91 VCAM1 IL10 CD40LG
18 cellular response to organic cyclic compound GO:0071407 9.91 TNF IL1B CCL5 CCL2
19 cell chemotaxis GO:0060326 9.91 VCAM1 CXCL10 CCR6 CCL5 CCL2
20 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.9 CXCL9 CXCL8 CXCL10
21 regulation of insulin secretion GO:0050796 9.9 TNF IL1B CCL5
22 response to glucocorticoid GO:0051384 9.9 TNF PTGS2 IL6 IL10
23 inflammatory response GO:0006954 9.9 TNF PTGS2 IL6 IL1B IL10 CXCL9
24 positive regulation of interleukin-6 production GO:0032755 9.89 TNF IL6 IL1B
25 positive regulation of cell adhesion GO:0045785 9.88 VEGFA TNF CCL5
26 positive chemotaxis GO:0050918 9.88 VEGFA CXCL10 CCL5
27 positive regulation of smooth muscle cell proliferation GO:0048661 9.88 TNF PTGS2 IL6 CCL5
28 neutrophil chemotaxis GO:0030593 9.88 IL1B CXCL9 CXCL8 CXCL10 CCL5 CCL2
29 positive regulation of nitric oxide biosynthetic process GO:0045429 9.87 TNF PTGS2 IL1B
30 monocyte chemotaxis GO:0002548 9.87 IL6 CCL5 CCL2
31 negative regulation of viral genome replication GO:0045071 9.86 TNF MX1 CCL5
32 humoral immune response GO:0006959 9.86 TNF IL6 CCR6 CCL2
33 cellular response to lipopolysaccharide GO:0071222 9.86 TNF IL6 IL1B IL10 CXCL9 CXCL8
34 positive regulation of interleukin-6 secretion GO:2000778 9.85 TNF MBP IL1B
35 protein kinase B signaling GO:0043491 9.85 TNF IL1B CCL5 CCL2
36 chemokine-mediated signaling pathway GO:0070098 9.85 CXCL9 CXCL8 CXCL10 CCR6 CCL5 CCL2
37 cellular response to fibroblast growth factor stimulus GO:0044344 9.84 CXCL8 CCL5 CCL2
38 lipopolysaccharide-mediated signaling pathway GO:0031663 9.84 TNF IL1B CCL5 CCL2
39 positive regulation of vascular endothelial growth factor production GO:0010575 9.83 PTGS2 IL6 IL1B
40 leukocyte cell-cell adhesion GO:0007159 9.83 VCAM1 CD40LG CCL5
41 positive regulation of JAK-STAT cascade GO:0046427 9.83 TNF IL6 IL10 CCL5
42 negative regulation of neurogenesis GO:0050768 9.82 TNF IL6 IL1B
43 positive regulation of glial cell proliferation GO:0060252 9.8 TNF IL6 IL1B
44 positive regulation of T cell proliferation GO:0042102 9.8 VCAM1 TNFSF13B IL6 IL1B CD40LG CCL5
45 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.79 TNF IL1B IL10
46 leukocyte chemotaxis GO:0030595 9.78 IL10 CXCL9 CXCL8 CXCL10
47 positive regulation of neuroinflammatory response GO:0150078 9.74 TNF IL6 IL1B
48 regulation of neuroinflammatory response GO:0150077 9.73 PTGS2 IL6
49 negative regulation of lipid storage GO:0010888 9.73 TNF IL6
50 endothelial cell apoptotic process GO:0072577 9.72 TNF IL10

Molecular functions related to Viral Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.32 VEGFA TNFSF13B TNF PTGS2 MX1 MBP
2 signaling receptor binding GO:0005102 9.8 TNFSF13B MOG LGI1 CXCL10 CCL2
3 chemoattractant activity GO:0042056 9.43 VEGFA CXCL10 CCL5
4 cytokine activity GO:0005125 9.4 VEGFA TNFSF13B TNF IL6 IL1B IL10
5 chemokine activity GO:0008009 9.35 CXCL9 CXCL8 CXCL10 CCL5 CCL2
6 tumor necrosis factor receptor binding GO:0005164 9.33 TNFSF13B TNF CD40LG
7 CXCR3 chemokine receptor binding GO:0048248 9.32 CXCL9 CXCL10

Sources for Viral Encephalitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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