MCID: VRL008
MIFTS: 36

Viral Exanthem

Categories: Infectious diseases, Skin diseases
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Aliases & Classifications for Viral Exanthem

MalaCards integrated aliases for Viral Exanthem:

Name: Viral Exanthem 11 14 16 71 33
Nonspecific Exanthematous Viral Infection 33
Viral Disease Characterised by Exanthem 33
Viral Exanthem, Unspecified 33
Nonspecific Viral Exanthem 33
Nonspecific Viral Rash 33
Viral Enanthema Nos 33
Viral Exanthema Nos 33
Viral Exanthemata 33
Virus Exanthema 33
Viral Rash Nos 33

Classifications:



External Ids:

Disease Ontology 11 DOID:8672
ICD9CM 34 057.8
SNOMED-CT 68 186577001
UMLS 71 C0029841 C0153062

Summaries for Viral Exanthem

MalaCards based summary: Viral Exanthem, also known as nonspecific exanthematous viral infection, is related to pityriasis rosea and chikungunya, and has symptoms including exanthema An important gene associated with Viral Exanthem is IZUMO4 (IZUMO Family Member 4), and among its related pathways/superpathways are Immune response IL-23 signaling pathway and NF-kappaB Signaling. Affiliated tissues include skin and liver, and related phenotypes are immune system and respiratory system

Related Diseases for Viral Exanthem

Diseases in the Exanthem family:

Bacterial Exanthem Viral Exanthem

Diseases related to Viral Exanthem via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 796)
# Related Disease Score Top Affiliating Genes
1 pityriasis rosea 30.2 CD8A CD4 ACE2
2 chikungunya 29.9 TNF IL6 CRP
3 viral infectious disease 29.7 TNF IL6 IFNG CD4 ACE2
4 meningitis 29.5 TNF IL6 IFNG CRP
5 allergic disease 29.5 TNF IL6 IFNG CD8A CD4
6 exanthem 29.5 TNF IL6 IFNG CRP CD8A CD4
7 covid-19 29.2 TNF IL6 CRP ACE2 ACE
8 poliomyelitis 29.1 TNF IL6 IFNG CD8A CD4 ACE2
9 fungal infectious disease 29.1 TNF IL6 IFNG CRP CD8A CD4
10 urticaria 28.7 TNF IL6 IFNG CRP CD4 ACE
11 pneumonia 28.5 TNF IL6 IFNG CRP CD8A ACE2
12 hilar lung neoplasm 10.3 CD8A CD4
13 syphilitic meningitis 10.3 CRP CD4
14 oral tuberculosis 10.3 CD8A CD4
15 early yaws 10.3 CD8A CD4
16 intracranial abscess 10.3 CRP CD4
17 diffuse infiltrative lymphocytosis syndrome 10.3 CD8A CD4
18 wissler-fanconi syndrome 10.3 CD8A CD4
19 autoimmune lymphoproliferative syndrome, type iia 10.3 CD8A CD4
20 viral laryngitis 10.3 CRP ACE2
21 purulent endophthalmitis 10.3 CRP CD4
22 encephalitozoonosis 10.3 CD8A CD4
23 cork-handlers' disease 10.3 CD8A CD4
24 pyomyositis 10.3 CRP CD4
25 breast abscess 10.3 CRP CD4
26 follicular mucinosis 10.3 CD8A CD4
27 acute pulmonary heart disease 10.3 CRP ACE2
28 intracranial sinus thrombosis 10.3 CRP ACE2
29 bird fancier's lung 10.3 CD8A CD4
30 exanthema subitum 10.3 IZUMO4 CD4
31 parapsoriasis 10.3 CD8A CD4
32 primary syphilis 10.3 CD8A CD4
33 primary cutaneous gamma-delta t-cell lymphoma 10.3 CD8A CD4
34 gastroduodenitis 10.3 CD8A CD4
35 thymic dysplasia 10.3 CD8A CD4
36 mooren's ulcer 10.3 CD8A CD4
37 herpes simplex virus keratitis 10.3 CD8A CD4
38 norwegian scabies 10.3 CD8A CD4
39 beta-lactam allergy 10.3 CRP CD4
40 folic acid deficiency anemia 10.3 EPO CRP
41 congenital syphilis 10.3 CRP CD4
42 spongiotic dermatitis 10.3 CD8A CD4
43 mikulicz disease 10.3 CRP CD4
44 autoimmune peripheral neuropathy 10.2 CD8A CD4
45 glanders 10.2 CD8A CD4
46 lymphangitis 10.2 CRP CD4
47 retinitis pigmentosa 46 10.2 CD8A CD4
48 marburg hemorrhagic fever 10.2 CD8A ACE2
49 ulcerative stomatitis 10.2 CD8A CD4
50 rheumatoid arthritis interstitial lung disease 10.2 TNF CRP

Graphical network of the top 20 diseases related to Viral Exanthem:



Diseases related to Viral Exanthem

Symptoms & Phenotypes for Viral Exanthem

UMLS symptoms related to Viral Exanthem:


exanthema

MGI Mouse Phenotypes related to Viral Exanthem:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.65 ACE ACE2 CD4 CD8A CRP EPO
2 respiratory system MP:0005388 9.17 ACE2 EPO IFNG IL6 MDFI TNF

Drugs & Therapeutics for Viral Exanthem

Search Clinical Trials, NIH Clinical Center for Viral Exanthem

Genetic Tests for Viral Exanthem

Anatomical Context for Viral Exanthem

Organs/tissues related to Viral Exanthem:

MalaCards : Skin, Liver

Publications for Viral Exanthem

Articles related to Viral Exanthem:

(show top 50) (show all 79)
# Title Authors PMID Year
1
The mixed spongiotic and interface reaction pattern: A study of clinical and histopathologic findings. 62
36445270 2022
2
Skin, mucosa and nail findings in hospitalized pediatric patients with Coronavirus disease-2019 (COVID-19). 62
36435635 2022
3
Acute Epstein-Barr virus infection resembling cutaneous T-cell lymphoma. 62
36349388 2022
4
Eruptive Hypomelanosis: An Under-Recognized Viral Exanthem. 62
36270393 2022
5
Drug-Induced vs. Viral Maculopapular Exanthem-Resolving the Dilemma. 62
35645232 2022
6
A Case Report of Secondary Syphilis Co-Infected with Measles: A Diagnostic Dilemma with Fever and Rash. 62
35622697 2022
7
Angioimmunoblastic T-cell Lymphoma Mimicking DRESS Syndrome. 62
35659145 2022
8
Group A Streptococcal Pharyngitis Testing Appropriateness in Pediatric Acute Care Settings. 62
32898124 2022
9
Adult T-cell leukemia/lymphoma clinically confused with viral/drug skin eruptions and pathologically misinterpreted as mycosis fungoides/Sézary syndrome. 62
33354782 2021
10
Dermatological opinions are imperative in ambulatory and acute care settings for pediatric skin disorders - HL-SkinPed. 62
33994265 2021
11
Dermatologic manifestations of COVID-19: a comprehensive systematic review. 62
33141443 2021
12
Differentiating Between β-Lactam-Induced Serum Sickness-Like Reactions and Viral Exanthem in Children Using a Graded Oral Challenge. 62
32898711 2021
13
Cutaneous manifestations associated with COVID-19 in children: A systematic review. 62
34017709 2021
14
Cutaneous manifestations of COVID-19. 62
33560783 2021
15
T-Cell Lymphoblastic Lymphoma/Leukemia Presenting as a Diffuse Viral Exanthem-like Reaction: A Clinical and Histopathological Challenge. 62
32732689 2020
16
The trend of cutaneous lesions during COVID-19 pandemic: lessons from a meta-analysis and systematic review. 62
32936462 2020
17
A Case of a Rare Tick-Borne Illness in Michigan Associated With Reversible Splenial Lesion Syndrome: When It Is Not a Viral Exanthem. 62
32248700 2020
18
An Atypical Presentation of Pityriasis Rosea Localized to the Extremities. 62
32944477 2020
19
Viral exanthem with "Spins and needles sensation" on extremities of a COVID-19 patient: A self-reported case from an Indonesian medical frontliner. 62
32437936 2020
20
COVID-19 presenting as a viral exanthem and detected during admission prescreening in a hematopoietic cell transplant recipient. 62
32646836 2020
21
Mycosis fungoides manifesting as a morbilliform eruption mimicking a viral exanthem. 62
32717002 2020
22
Viral exanthem in COVID-19, a clinical enigma with biological significance. 62
32294270 2020
23
Atypical acral swelling and viral exanthem with parechovirus meningitis. 62
31833105 2020
24
Simultaneous occurrence of hand, foot and mouth disease and pityriasis rosea: double viral exanthem. 62
29144097 2019
25
Eruptive pseudoangiomatosis - cherry angiomas with perilesional halo. 62
29327698 2018
26
What's in a Rash? Viral Exanthem Versus CBRNE Exposure: Teleconsultation Support for Two Special Forces Soldiers With Diffuse Rash in an Austere Environment. 62
29889970 2018
27
Assessment of histopathological features of maculopapular viral exanthem and drug-induced exanthem. 62
28914958 2017
28
Main Characteristics of Zika Virus Exanthema in Guadeloupe. 62
28241170 2017
29
Viral exanthems: An update on laboratory testing of the adult patient. 62
28413059 2017
30
Coxsackievirus A6 Polymorphic Exanthem in Israeli Children. 62
26463513 2016
31
Early diagnosis of post-varicella necrotising fasciitis: A medical and surgical emergency. 62
27251524 2016
32
Eruptive hypomelanosis in a child, a new viral exanthem. 62
26728822 2016
33
Generalized benign cutaneous reaction to cytarabine. 62
26321388 2015
34
Update on hand-foot-and-mouth disease. 62
25889136 2015
35
Reappearance of chikungunya, formerly called dengue, in the Americas. 62
25816211 2015
36
Cutaneous manifestations of angioimmunoblastic T-cell lymphoma: clinical and pathological characteristics. 62
25794369 2015
37
Vesiculobullous viral exanthem due to chikungunya in an infant. 62
25593800 2014
38
[Generalized inflammatory epidermolysis bullosa acquisita initially diagnosed as viral exanthem: a rare disease within the subepidermal blistering disorders]. 62
25260302 2014
39
Eruptive hypomelanosis: a novel exanthem associated with viral symptoms in children. 62
25229328 2014
40
Approach to drug allergies in the childhood. 62
26078643 2014
41
Viral exanthems: an update. 62
24552405 2013
42
Black heel (talon noir) associated with a viral exanthem. 62
24222298 2013
43
The spectrum of histopathologic findings in cutaneous eruptions associated with influenza A (H1N1) infection. 62
23216248 2013
44
Atypical hydroa vacciniforme-like epstein-barr virus associated T/NK-cell lymphoproliferative disorder. 62
23169419 2012
45
Interesting effect of Malassezia spp. infection on dermatoses of other origins. 62
22097998 2011
46
[Inflammatory dermatoses]. 62
21779755 2011
47
Echovirus 18 meningitis in southern Taiwan. 62
20881653 2011
48
Image in medicine. An exanthem with an annular pattern in a 2-year-old girl. Atypical viral exanthem with an annular pattern. 62
20838712 2010
49
Exanthema in Legionnaires' disease mimicking a severe cutaneous drug reaction. 62
19438525 2009
50
Approach to the morbilliform eruption in the hematopoietic transplant patient. 62
18070682 2007

Variations for Viral Exanthem

Expression for Viral Exanthem

Search GEO for disease gene expression data for Viral Exanthem.

Pathways for Viral Exanthem

Pathways related to Viral Exanthem according to GeneCards Suite gene sharing:

(show all 28)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.44 TNF IL6 IFNG CD4
2 12.42 XRCC5 TNF IFNG CD8A
3
Show member pathways
11.99 TNF IFNG CD8A CD4
4 11.86 TNF IL6 IFNG
5
Show member pathways
11.86 TNF ACE2 ACE
6
Show member pathways
11.84 IFNG CD8A CD4
7
Show member pathways
11.73 CD4 IFNG IL6
8
Show member pathways
11.73 TNF IL6 IFNG CD4
9 11.64 IL6 IFNG CD4
10 11.59 IL6 IFNG CD4
11 11.57 CD4 CD8A IFNG TNF
12
Show member pathways
11.54 TNF IL6 IFNG
13
Show member pathways
11.5 TNF IL6 IFNG
14 11.47 TNF IL6 IFNG CRP
15
Show member pathways
11.44 IL6 CRP CD8A CD4 ACE2
16 11.42 TNF IFNG CD4
17 11.42 TNF IL6 IFNG
18 11.35 IFNG IL6 TNF
19 11.22 TNF IL6 IFNG CD8A CD4
20 11.18 TNF IL6 IFNG
21 11.16 TNF IL6 IFNG EPO CD8A CD4
22 11.13 TNF IL6 ACE2
23 11.06 TNF IL6 IFNG
24 11.02 TNF IL6 IFNG CD4
25 10.86 TNF IL6 CRP
26 10.81 IFNG CD4
27 10.6 ACE2 IL6
28
Show member pathways
10.25 TNF IL6

GO Terms for Viral Exanthem

Cellular components related to Viral Exanthem according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.62 XRCC5 TNF IZUMO4 IL6 IFNG EPO

Biological processes related to Viral Exanthem according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of interleukin-1 beta production GO:0032731 10 TNF IL6 IFNG
2 humoral immune response GO:0006959 9.99 IFNG IL6 TNF
3 positive regulation of protein kinase activity GO:0045860 9.93 XRCC5 EPO CD4
4 regulation of insulin secretion GO:0050796 9.93 TNF IL6 IFNG
5 positive regulation of chemokine production GO:0032722 9.91 IFNG IL6 TNF
6 acute-phase response GO:0006953 9.88 IL6 EPO CRP
7 neutrophil mediated immunity GO:0002446 9.86 IL6 ACE
8 angiotensin maturation GO:0002003 9.85 ACE2 ACE
9 positive regulation of neurogenesis GO:0050769 9.85 XRCC5 IFNG ACE
10 vascular endothelial growth factor production GO:0010573 9.8 TNF IL6
11 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.78 ACE2 ACE
12 positive regulation of nitrogen compound metabolic process GO:0051173 9.62 IFNG TNF
13 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.56 IFNG TNF
14 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.56 TNF IL6 IFNG EPO
15 positive regulation of vitamin D biosynthetic process GO:0060557 9.46 TNF IFNG
16 negative regulation of lipid storage GO:0010888 9.1 TNF IL6 CRP

Molecular functions related to Viral Exanthem according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidyl-dipeptidase activity GO:0008241 8.92 ACE2 ACE

Sources for Viral Exanthem

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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