MCID: VRL004
MIFTS: 35

Viral Labyrinthitis

Categories: Ear diseases, Infectious diseases, Neuronal diseases

Aliases & Classifications for Viral Labyrinthitis

MalaCards integrated aliases for Viral Labyrinthitis:

Name: Viral Labyrinthitis 12 15 71
Epidemic Vertigo 12 32
Vestibular Neuronitis 71

Classifications:



External Ids:

Disease Ontology 12 DOID:12357
ICD9CM 34 386.35
SNOMED-CT 67 34243007
ICD10 32 A88.1
UMLS 71 C0155508 C0751908

Summaries for Viral Labyrinthitis

Disease Ontology : 12 A labyrinthitis which involves viral infection of the inner ear through the upper airway or the blood stream. The symptoms may include hearing loss and ringing in the ears. If the virus reaches the vestibular system, dizziness, severe vertigo with nausea and vomiting, and imbalance can occur.

MalaCards based summary : Viral Labyrinthitis, also known as epidemic vertigo, is related to labyrinthitis and sensorineural hearing loss. An important gene associated with Viral Labyrinthitis is RERGL (RERG Like), and among its related pathways/superpathways is Gap junction trafficking. The drugs Methylprednisolone and Prednisolone acetate have been mentioned in the context of this disorder. Affiliated tissues include testes, eye and bone, and related phenotypes are hearing/vestibular/ear and no phenotypic analysis

Related Diseases for Viral Labyrinthitis

Diseases in the Labyrinthitis family:

Viral Labyrinthitis

Diseases related to Viral Labyrinthitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Related Disease Score Top Affiliating Genes
1 labyrinthitis 30.4 GJB6 GJB2 ATOH1
2 sensorineural hearing loss 29.1 GJB6 GJB2 ATOH1
3 nonsyndromic hearing loss and deafness, dfna3 10.2 GJB6 GJB2
4 nonsyndromic hearing loss and deafness, dfnb1 10.2 GJB6 GJB2
5 dfnb1 10.2 GJB6 GJB2
6 deafness, autosomal dominant 24 10.1 GJB6 GJB2
7 pseudoainhum 10.1 GJB6 GJB2
8 purulent labyrinthitis 10.1 GJB6 GJB2
9 congenital cytomegalovirus 10.1 GJB6 GJB2
10 deafness, autosomal recessive 1b 10.1 GJB6 GJB2
11 deafness, x-linked 2 10.1 GJB6 GJB2
12 deafness, autosomal dominant 3b 10.1 GJB6 GJB2
13 keratitis-ichthyosis-deafness syndrome, autosomal dominant 10.1 GJB6 GJB2
14 deafness, autosomal dominant 64 10.1 GJB6 GJB2
15 deafness, autosomal dominant 59 10.1 GJB6 GJB2
16 deafness, autosomal dominant 3a 10.1 GJB6 GJB2
17 knuckle pads 10.1 GJB6 GJB2
18 knuckle pads, leukonychia, and sensorineural deafness 10.1 GJB6 GJB2
19 vohwinkel syndrome 10.1 GJB6 GJB2
20 x-linked nonsyndromic deafness 10.1 GJB6 GJB2
21 hodgkin's lymphoma, nodular sclerosis 10.1 GJB6 GJB2
22 episodic ataxia, type 4 10.1 RERGL PIK3C2G
23 branchiootic syndrome 1 10.1
24 mumps 10.1
25 clouston syndrome 10.1 GJB6 GJB2
26 vestibular disease 10.1 GJB6 GJB2
27 oculodentodigital dysplasia 10.0 GJB6 GJB2
28 deafness, autosomal recessive 1a 10.0 GJB6 GJB2
29 deafness, autosomal recessive 12 10.0 GJB6 GJB2
30 autosomal dominant non-syndromic sensorineural deafness type dfna 10.0 GJB6 GJB2
31 ear malformation 10.0 GJB2 ATOH1
32 branchiootorenal syndrome 10.0 GJB6 GJB2
33 erythrokeratodermia variabilis et progressiva 1 10.0 GJB6 GJB2
34 peripheral vertigo 10.0 KCNE3 GJB2
35 keratitis, hereditary 10.0 GJB6 GJB2
36 palmoplantar keratosis 9.9 GJB6 GJB2
37 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.9
38 exanthem 9.9
39 parotitis 9.9
40 vestibular neuronitis 9.9
41 neuritis 9.9
42 encephalitis 9.9
43 pathologic nystagmus 9.9
44 sudden sensorineural hearing loss 9.9
45 encephalopathy 9.9
46 pendred syndrome 9.9 GJB6 GJB2
47 orthostatic intolerance 9.9
48 meningoencephalitis 9.9
49 neuronitis 9.9
50 deafness, autosomal recessive 4, with enlarged vestibular aqueduct 9.8 GJB6 GJB2

Comorbidity relations with Viral Labyrinthitis via Phenotypic Disease Network (PDN):


Hypertension, Essential Labyrinthitis
Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Viral Labyrinthitis:



Diseases related to Viral Labyrinthitis

Symptoms & Phenotypes for Viral Labyrinthitis

MGI Mouse Phenotypes related to Viral Labyrinthitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hearing/vestibular/ear MP:0005377 9.26 ATOH1 GJB2 GJB6 KCNE3
2 no phenotypic analysis MP:0003012 9.02 AQP6 ATOH1 GJB2 GJB6 KCNE3

Drugs & Therapeutics for Viral Labyrinthitis

Drugs for Viral Labyrinthitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 37)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
2 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
3
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
4
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
5
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
6
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
7
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
8 Hormone Antagonists Phase 4
9 Anti-Inflammatory Agents Phase 4
10 glucocorticoids Phase 4
11 Antineoplastic Agents, Hormonal Phase 4
12 Hormones Phase 4
13 Gastrointestinal Agents Phase 4
14 Antiemetics Phase 4
15 Methylprednisolone Acetate Phase 4
16 Betamethasone benzoate Phase 4
17 Betamethasone Valerate Phase 4 2152-44-5
18 Betamethasone sodium phosphate Phase 4
19 Betamethasone-17,21-dipropionate Phase 4
20
Cilostazol Approved, Investigational Phase 3 73963-72-1 2754
21 Protective Agents Phase 3
22 Autonomic Agents Phase 3
23 Neuroprotective Agents Phase 3
24 Ginkgo Phase 3
25 Anti-Asthmatic Agents Phase 3
26 Respiratory System Agents Phase 3
27 Fibrinolytic Agents Phase 3
28 Platelet Aggregation Inhibitors Phase 3
29 Vasodilator Agents Phase 3
30 Phosphodiesterase Inhibitors Phase 3
31 Bronchodilator Agents Phase 3
32 Phosphodiesterase 3 Inhibitors Phase 3
33
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
34
Dexamethasone acetate Approved, Investigational, Vet_approved Early Phase 1 1177-87-3
35
Dexamethasone Approved, Investigational, Vet_approved Early Phase 1 50-02-2 5743
36 Kava Approved, Investigational, Nutraceutical 9000-38-8
37 BB 1101 Early Phase 1

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 Acute Unilateral Vestibulopathy and Corticosteroid Treatment Suspended NCT02912182 Phase 4 Betamethasone;Placebo;Prednisolone
2 The Efficacy of Steroid Therapy in Vestibular Neuritis Confirmed by Head Impulse Test: Prospective Randomized Controlled Study Completed NCT02098330 Phase 3 Ginkgo biloba & Methylprednisolone;Ginkgo biloba
3 A Single-center, Prospective, Randomized, Parallel Group, Placebo-controlled Exploratory Study on the Effect of Renexin Tablet in Patients With Recurrent Vestibulopathy Terminated NCT01895400 Phase 3 Renexin (cilostazol 100mg + gingko biloba extract 80 mg);Placebo
4 Prednisone Treatment for Vestibular Neuronitis Completed NCT00271791 Phase 2 Prednisone;Prednisone
5 Complementary/Alternative Medicine for Vestibulopathy Completed NCT00032383 Phase 1, Phase 2
6 INVENT VPT: Incremental Velocity Error as a New Treatment in Vestibular Rehabilitation Not yet recruiting NCT03846830 Phase 2
7 Do Migrainous Vertigo Patients Have More Hypersensitivity in Their Vestibular System Than Migraine Patients Without Vertigo? Unknown status NCT00901953
8 The Role of Corticosteroids and Vestibular Exercises in Recovery of Vestibular Neuritis: a Prospective Randomized Controlled Clinical Trial Unknown status NCT01231009 Early Phase 1 Corticosteroids
9 Characterisation of Cortical Vestibular Evoked Potentials (C-VEPs): A Comparative Study of Normal Ears Versus Those With Vestibular Deficits Unknown status NCT02463695
10 Positive Diagnosis of Vestibular Neuritis Using Fluid Attenuated Inversion Recuperation (FLAIR) Sequence, One Hour After Intravenous Gadolinium Injection, on a 1.5 Tesla Completed NCT03452410
11 Recovery of Visual Acuity in Vestibular Deficits Completed NCT00411216
12 Home-based Computer Gaming in Vestibular Rehabilitation: Effects on Gaze and Balance Impairment Completed NCT01943955
13 Clinical Evaluation of a Novel Balance, Vestibular and Oculomotor Assessment Tool Completed NCT02171312
14 Which Treatment is Most Effective When Treating Vestibular Neuritis: Corticosteroid Treatment Alone or Combined Corticosteroid Treatment and Vestibular Rehabilitation? Recruiting NCT03821155 Corticosteroid
15 Production of a Device to Obtain Continuous Ambulatory Vestibular Assessment (CAVA) - Dizziness Trial Recruiting NCT04026516
16 Assessment and Treatment of Patients With Long-term Dizziness in Primary Care Recruiting NCT02655575
17 Vestibulopathy With Vestibulo Ocular Reflex (VOR) Gain Deficit - Characteristics of Overt and Covert Saccadic Eye Movements Measured by the Video Head Impulse Test (vHIT) Not yet recruiting NCT03271775

Search NIH Clinical Center for Viral Labyrinthitis

Genetic Tests for Viral Labyrinthitis

Anatomical Context for Viral Labyrinthitis

MalaCards organs/tissues related to Viral Labyrinthitis:

40
Testes, Eye, Bone, Brain, Endothelial

Publications for Viral Labyrinthitis

Articles related to Viral Labyrinthitis:

(show top 50) (show all 83)
# Title Authors PMID Year
1
Hydrops of the organ of Corti. 61
27241920 2016
2
Benign paroxysmal positional vertigo after nonotologic surgery: case series. 61
25838683 2015
3
Tinnitus pitch and minimum masking levels in different etiologies. 61
24684405 2014
4
Audiovestibular impairment presenting as a portent of vertebrobasilar infarction. 61
24401972 2014
5
Recent advances in viral inner ear disorders. 61
22902415 2012
6
Auditory and vestibular defects induced by experimental labyrinthitis following herpes simplex virus in mice. 61
21526906 2011
7
Clinical characteristics of delayed endolymphatic hydrops in Japan: A nationwide survey by the Peripheral Vestibular Disorder Research Committee of Japan. 61
20441535 2010
8
Familial unilateral deafness and delayed endolymphatic hydrops. 61
17497713 2007
9
Diagnostic value of vestibulo-ocular reflex parameters in the detection and characterization of labyrinthine lesions. 61
16791046 2006
10
[Temporal bone histopathology exhibiting cochleosaccular degeneration in a patient with profound deafness]. 61
15103945 2004
11
Horizontal vestibulo-ocular reflex dynamics in acute vestibular neuritis and viral labyrinthitis: evidence of otolith-canal interaction. 61
14977076 2004
12
Treatment of idiopathic sudden sensorineural hearing loss with antiviral therapy: a prospective, randomized, double-blind clinical trial. 61
14653370 2003
13
Vestibular histopathology of the human temporal bone. What can we learn? 61
11710467 2001
14
HSV-1 not only in human vestibular ganglia but also in the vestibular labyrinth. 61
11729328 2001
15
[Benign paroxysmal positional vertigo secondary to surgical maneuvers on superior maxilla]. 61
11526631 2001
16
Delayed endolymphatic hydrops: study and review of clinical implications and surgical treatment. 61
11233350 2001
17
Therapy of idiopathic sudden sensorineural hearing loss: antiviral treatment of experimental herpes simplex virus infection of the inner ear. 61
10335700 1999
18
Subjective visual vertical in peripheral unilateral vestibular diseases. 61
10378186 1999
19
[Delayed endolymphatic hydrops]. 61
10205936 1998
20
The etiology of idiopathic sudden sensorineural hearing loss. Experimental herpes simplex virus infection of the inner ear. 61
9661753 1998
21
Antiviral treatment of idiopathic sudden sensorineural hearing loss: a prospective, randomized, double-blind clinical trial. 61
9726671 1998
22
Dizzy patients: the varieties of vertigo. 61
9636351 1998
23
Magnetic resonance imaging of the inner ear in patients with idiopathic sudden sensorineural hearing loss. 61
9833208 1998
24
Viral theory for Ménière's disease and endolymphatic hydrops: overview and new therapeutic options for viral labyrinthitis. 61
9616689 1997
25
Patterns of neural degeneration in the human cochlea and auditory nerve: implications for cochlear implantation. 61
9334769 1997
26
Morphological changes of stria vascularis in congenital hearing impairment due to membranous labyrinth underdevelopment. 61
9288205 1997
27
Effect of adult-onset deafness on the human central auditory system. 61
9153102 1997
28
Vestibular changes after guinea pig cytomegalovirus infection. 61
8749107 1995
29
[Benign paroxysmal positional vertigo. Diagnosis, course, physiopathology and treatment]. 61
8178095 1994
30
Pathology of prelingual profound deafness: magnitude of labyrinthitis fibro-ossificans. 61
8109636 1994
31
An unusual cause of benign paroxysmal positional vertigo. 61
8289008 1993
32
[Recovery from Meniere's disease]. 61
8209688 1993
33
Development of high endothelial venule-like characteristics in the spiral modiolar vein induced by viral labyrinthitis. 61
8395627 1993
34
Sensorineural hearing loss: more than meets the eye? 61
8427110 1993
35
[An experimental study of hearing loss caused by mumps virus in guinea pigs]. 61
8031587 1993
36
[Effect of steroid hormone on experimental viral labyrinthitis in guinea pigs]. 61
1660016 1991
37
Guinea pig model of transplacental congenital cytomegaloviral infection with analysis for labyrinthitis. 61
1647141 1991
38
Idiopathic sudden sensorineural hearing loss and postnatal viral labyrinthitis: a statistical comparison of temporal bone findings. 61
2244729 1990
39
Delayed endolymphatic hydrops and its relationship to Meniére's disease. 61
2241008 1990
40
Comparative experimental viral labyrinthitis. 61
2177958 1990
41
Clinical aspects of inflight incapacitations in commercial aviation. 61
2317181 1990
42
Survival of spiral ganglion cells in profound sensorineural hearing loss: implications for cochlear implantation. 61
2729822 1989
43
Experimental herpes simplex virus and cytomegalovirus labyrinthitis. 61
2538996 1989
44
Temporal sequence of viral antigen expression in the cochlea induced by cytomegalovirus. 61
2844054 1988
45
Faint palatal rash and viral labyrinthitis. 61
2893203 1988
46
Viral infection and the inner ear. 61
2845327 1988
47
Viral labyrinthitis/encephalitis: Marondera area. 61
3607864 1986
48
[Experimental viral labyrinthitis--an immunohistochemical investigation of the cochlear lesion]. 61
3009291 1986
49
Demonstration of pseudorabies virus DNA in the mouse inner ear by an in situ nucleic acid hybridization technique in plastic embedded bony material. 61
3007764 1986
50
Hearing loss in experimental cytomegalovirus infection of the guinea pig inner ear: prevention by systemic immunity. 61
2992353 1985

Variations for Viral Labyrinthitis

Expression for Viral Labyrinthitis

Search GEO for disease gene expression data for Viral Labyrinthitis.

Pathways for Viral Labyrinthitis

Pathways related to Viral Labyrinthitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.61 GJB6 GJB2

GO Terms for Viral Labyrinthitis

Cellular components related to Viral Labyrinthitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 gap junction GO:0005921 8.96 GJB6 GJB2
2 connexin complex GO:0005922 8.62 GJB6 GJB2

Biological processes related to Viral Labyrinthitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell communication GO:0007154 9.32 GJB6 GJB2
2 gap junction assembly GO:0016264 9.26 GJB6 GJB2
3 cell communication by electrical coupling GO:0010644 9.16 GJB6 GJB2
4 gap junction-mediated intercellular transport GO:1990349 8.96 GJB6 GJB2
5 inner ear development GO:0048839 8.8 GJB6 GJB2 ATOH1

Molecular functions related to Viral Labyrinthitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 gap junction channel activity GO:0005243 8.96 GJB6 GJB2
2 gap junction channel activity involved in cell communication by electrical coupling GO:1903763 8.62 GJB6 GJB2

Sources for Viral Labyrinthitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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