MCID: VRL012
MIFTS: 49

Viral Meningitis

Categories: Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Viral Meningitis

MalaCards integrated aliases for Viral Meningitis:

Name: Viral Meningitis 12 3 15 73
Meningitis, Viral 44
Meningitis Viral 55

Classifications:



External Ids:

Disease Ontology 12 DOID:10310
ICD10 33 A87 A87.9
ICD9CM 35 047.9
MeSH 44 D008587
NCIt 50 C118298
SNOMED-CT 68 58170007
UMLS 73 C0025297

Summaries for Viral Meningitis

Disease Ontology : 12 A meningitis that has material basis in a viral infection.

MalaCards based summary : Viral Meningitis, also known as meningitis, viral, is related to meningitis and encephalitis. An important gene associated with Viral Meningitis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Salmon Calcitonin and Calcitonin gene-related peptide have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and testes, and related phenotype is immune system.

CDC : 3 EspaƱol: Meningitis viral

Wikipedia : 76 Viral meningitis, also known as aseptic meningitis, is a type of meningitis due to a viral infection. It... more...

Related Diseases for Viral Meningitis

Diseases in the Meningitis family:

Viral Meningitis Chronic Meningitis
Bacterial Meningitis

Diseases related to Viral Meningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 262)
# Related Disease Score Top Affiliating Genes
1 meningitis 31.8 IL6 IFNG CXCL8 CRP CCL2
2 encephalitis 30.3 CCL2 CCL5 CXCL10
3 bacterial meningitis 29.9 IL6 CXCL8 CRP
4 aseptic meningitis 29.8 CXCL8 IFNG
5 tuberculous meningitis 29.7 CCL2 CXCL8
6 viral infectious disease 29.7 CCL5 CXCL10 CXCL8 IFNG IL6
7 viral encephalitis 29.0 CCL2 CCL5 CXCL10 IL6
8 mollaret meningitis 11.0
9 lymphocytic choriomeningitis 10.6
10 panniculitis 10.2 IFNG SERPINA1
11 eumycotic mycetoma 10.2 CCL5 IFNG
12 folliculitis 10.2 CCL5 IFNG
13 pelvic inflammatory disease 10.2 CCL2 CRP
14 orofacial granulomatosis 10.2 CCL5 IFNG
15 xanthogranulomatous pyelonephritis 10.2 CCL2 CRP
16 stevens-johnson syndrome/toxic epidermal necrolysis 10.2 CCL5 IFNG
17 pharyngitis 10.2 CRP CXCL8
18 septic arthritis 10.2 CRP CXCL8
19 wells syndrome 10.2 CRP CXCL8
20 meningitis and encephalitis 10.2
21 mycetoma 10.2 CCL5 CXCL8
22 extrapulmonary tuberculosis 10.2 CCL2 IFNG
23 myasthenic syndrome, congenital, 1a, slow-channel 10.1 CRP CXCL8
24 nonspecific interstitial pneumonia 10.1 CCL2 IFNG
25 japanese encephalitis 10.1 CCL5 CXCL10
26 african tick-bite fever 10.1 CCL5 IFNG
27 pyuria 10.1 CRP CXCL8
28 mycobacterium chelonae 10.1 CXCL8 CD14
29 macular holes 10.1 CCL2 CXCL8
30 cardiac rupture 10.1 CRP CXCL8
31 vulvovaginitis 10.1 CCL5 CXCL8
32 mycobacterium kansasii 10.1 CD14 CXCL8
33 apnea, obstructive sleep 10.1 CRP IL6
34 angina pectoris 10.1 CRP IL6
35 exanthem 10.1 CRP IL6
36 infective endocarditis 10.1 CRP IL6
37 mesenteric lymphadenitis 10.1 CRP IL6
38 prediabetes syndrome 10.1 CRP IL6
39 intermittent explosive disorder 10.1 CRP IL6
40 adult-onset still's disease 10.1 CRP IL6
41 hypersensitivity reaction type iii disease 10.1 CRP IL6
42 intermediate coronary syndrome 10.1 CRP IL6
43 systolic heart failure 10.1 CRP IL6
44 polyarteritis nodosa 10.1 CRP IL6
45 glaucomatocyclitic crisis 10.1 CXCL10 CXCL8
46 periapical granuloma 10.1 CCL5 CXCL8
47 asbestosis 10.1 IL6 SERPINA1
48 scleritis 10.1 CCL2 IFNG
49 transient arthritis 10.1 IL6 SERPINA1
50 fibromyalgia 10.1 IL6 SERPINA1

Comorbidity relations with Viral Meningitis via Phenotypic Disease Network (PDN):


Acute Cystitis Hypertension, Essential

Graphical network of the top 20 diseases related to Viral Meningitis:



Diseases related to Viral Meningitis

Symptoms & Phenotypes for Viral Meningitis

MGI Mouse Phenotypes related to Viral Meningitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.17 CCL2 CCL5 CD14 CRP CXCL10 IFNG

Drugs & Therapeutics for Viral Meningitis

Drugs for Viral Meningitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Salmon Calcitonin Approved, Investigational 47931-85-1 16129616
2
Calcitonin gene-related peptide Investigational 83652-28-2
3 Bone Density Conservation Agents
4 calcitonin

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Long Term Outcomes of EV71 CNS Infection Unknown status NCT00172393
2 Procalcitonin (PCT) as a Diagnostic Marker of Bacterial Infection in the Patients Admitted for Fever and/or Inflammatory Syndrome to the Internal Medicine Department Completed NCT02898948
3 Central Nervous System Infections in Denmark Recruiting NCT03418441
4 Role of CSF-CRPand Serum Procalcitonin in Differentiation Between Bacterial and Viral Meningitis in Children Not yet recruiting NCT03387969
5 A New Enzymatic Assay for Rapid Diagnosing of Central Nervous System Enteroviral Infection Withdrawn NCT00864903

Search NIH Clinical Center for Viral Meningitis

Cochrane evidence based reviews: meningitis, viral

Genetic Tests for Viral Meningitis

Anatomical Context for Viral Meningitis

MalaCards organs/tissues related to Viral Meningitis:

41
Brain, Spinal Cord, Testes, Bone, Monocytes, Lung, Heart

Publications for Viral Meningitis

Articles related to Viral Meningitis:

(show top 50) (show all 171)
# Title Authors Year
1
A study on correlations of procalcitonin and interleukin-6 with viral meningitis. ( 29917201 )
2018
2
Cerebrospinal fluid monocytes in bacterial meningitis, viral meningitis, and neuroborreliosis. ( 29628177 )
2018
3
Cerebrospinal Fluid Concentrations of Biogenic Amines: Potential Biomarkers for Diagnosis of Bacterial and Viral Meningitis. ( 29652804 )
2018
4
Viral Meningitis and Encephalitis. ( 30273240 )
2018
5
A New Scoring System for the Differential Diagnosis between Tuberculous Meningitis and Viral Meningitis. ( 30069169 )
2018
6
Comparison of C Reactive Protein and Procalcitonin Levels in Cerebrospinal Fluid and Serum to Differentiate Bacterial from Viral Meningitis. ( 30143494 )
2018
7
Molecular investigations of viral meningitis among HIV-infected adults in Accra, Ghana. ( 30153867 )
2018
8
Viral meningitis in the UK: time to speed up. ( 30153931 )
2018
9
Incidence, aetiology, and sequelae of viral meningitis in UK adults: a multicentre prospective observational cohort study. ( 30153934 )
2018
10
Cerebrospinal fluid lactate: a differential biomarker for bacterial and viral meningitis in children. ( 28866321 )
2017
11
With a little help from a computer: discriminating between bacterial and viral meningitis based on dominance-based rough set approach analysis. ( 28796045 )
2017
12
Viral meningitis: current issues in diagnosis and treatment. ( 28118219 )
2017
13
Etiological agents of viral meningitis in children from a dengue-endemic area, Southeast region of Brazil. ( 28320174 )
2017
14
Cerebrospinal fluid metabolomic profiling in tuberculous and viral meningitis: Screening potential markers for differential diagnosis. ( 28063937 )
2017
15
Diagnostic value of lactate, procalcitonin, ferritin, serum-C-reactive protein, and other biomarkers in bacterial and viral meningitis: A cross-sectional study. ( 28858084 )
2017
16
Viral meningitis: epidemiology and diagnosis. ( 27527750 )
2016
17
The usefulness of serum delta neutrophil index for differentiating bacterial and viral meningitis in the emergency department. ( 27752624 )
2016
18
Cerebrospinal fluid ferritin and albumin index: potential candidates for scoring system to differentiate between bacterial and viral meningitis in children. ( 26999689 )
2016
19
Meningitis retention syndrome: An unusual complication of viral meningitis. ( 27841204 )
2016
20
Predominance of enterovirus B and echovirus 30 as cause of viral meningitis in a UK population. ( 27367546 )
2016
21
Hospital admissions for viral meningitis in children in England over five decades: a population-based observational study. ( 27527749 )
2016
22
Procalcitonin as a Serum Biomarker for Differentiation of Bacterial Meningitis From Viral Meningitis in Children: Evidence From a Meta-Analysis. ( 26378091 )
2015
23
Viral Meningitis Epidemics and a Single, Recent, Recombinant and Anthroponotic Origin of Swine Vesicular Disease Virus. ( 26508717 )
2015
24
Restricted diffusion of the splenium of the corpus callosum in viral meningitis. ( 24707341 )
2014
25
Cerebral microbleeding in varicella-zoster viral meningitis: an early sign of vasculopathy? ( 24463624 )
2014
26
Confirmed viral meningitis with normal CSF findings. ( 25035443 )
2014
27
Molecular characterisation of enteroviruses and clinical findings from a cluster of paediatric viral meningitis cases in Tshwane, South Africa 2010-2011. ( 25176522 )
2014
28
Time trends of viral meningitis among young adults in Israel: 1978-2012. ( 24463724 )
2014
29
Underreporting of viral encephalitis and viral meningitis, Ireland, 2005-2008. ( 23965781 )
2013
30
Herpes zoster as a cause of viral meningitis in immunocompetent patients. ( 23307457 )
2013
31
Comparison of cytokine gene polymorphisms among Greek patients with invasive meningococcal disease or viral meningitis. ( 23378564 )
2013
32
Viral meningitis and encephalitis. ( 23981453 )
2013
33
Detection of herpes viruses in the cerebrospinal fluid of adults with suspected viral meningitis in Malawi. ( 22798048 )
2013
34
Viral meningitis admitted to an infectious diseases hospital: a retrospective case series. ( 24340533 )
2013
35
Trends in the management of viral meningitis at United States children's hospitals. ( 23530164 )
2013
36
Viral meningitis, active and reserve components, U.S. Armed Forces, 2002-2011. ( 22963254 )
2012
37
Impact of polymerase chain reaction results on patient management during a viral meningitis outbreak in Tropical North Queensland. ( 22313560 )
2012
38
Epidemics of viral meningitis caused by echovirus 6 and 30 in Korea in 2008. ( 22336050 )
2012
39
Vogt-Koyanagi-Harada syndrome: a rare but important differential diagnosis of viral meningitis. ( 21905951 )
2012
40
Acute bacterial and viral meningitis. ( 23221840 )
2012
41
Clinical prediction rule for differentiating tuberculous from viral meningitis. ( 22507645 )
2012
42
Viral meningitis: which patients can be discharged from the emergency department? ( 22709622 )
2012
43
Vertebral artery dissection associated with viral meningitis. ( 22909191 )
2012
44
Performance of thirteen clinical rules to distinguish bacterial and presumed viral meningitis in Vietnamese children. ( 23209715 )
2012
45
Lumbar puncture is not needed for all patients suspected to have viral meningitis. ( 22340799 )
2012
46
Patient Education Series. Viral meningitis in adults. ( 21403505 )
2011
47
A dural arteriovenous fistula in cavernous sinus developed from viral meningitis. ( 21748936 )
2011
48
Review of the etiologies of viral meningitis and encephalitis in a dengue endemic region. ( 21292281 )
2011
49
Descriptive analysis of viral meningitis in a general hospital: differences in the characteristics between children and adults. ( 21349608 )
2011
50
Cytokine and adhesion molecule expression evolves between the neutrophilic and lymphocytic phases of viral meningitis. ( 20626298 )
2010

Variations for Viral Meningitis

Expression for Viral Meningitis

Search GEO for disease gene expression data for Viral Meningitis.

Pathways for Viral Meningitis

Pathways related to Viral Meningitis according to GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.82 CCL2 CCL5 CD14 CRP CXCL10 CXCL8
2
Show member pathways
13.51 CCL2 CCL5 CD14 CXCL10 CXCL8 IFNG
3
Show member pathways
13.25 CCL2 CCL5 CXCL10 CXCL8 IL6
4
Show member pathways
13.22 CCL2 CCL5 CXCL10 CXCL8 IFNG IL6
5
Show member pathways
13.15 CCL2 CCL5 CXCL10 CXCL8 IL6
6
Show member pathways
12.91 CCL2 CCL5 CXCL8 IL6
7
Show member pathways
12.76 CCL2 CCL5 CD14 CXCL10 CXCL8 IFNG
8
Show member pathways
12.75 CCL2 CCL5 CXCL10 CXCL8
9
Show member pathways
12.66 CCL2 CCL5 CXCL10 CXCL8 IFNG IL6
10
Show member pathways
12.62 CCL5 CD14 CXCL10 CXCL8 IFNG IL6
11
Show member pathways
12.49 CCL2 CD14 IFNG IL6
12 12.47 CCL2 CCL5 CXCL10 IFNG
13
Show member pathways
12.26 CCL2 CCL5 CRP IFNG IL6
14
Show member pathways
12.24 CCL2 CXCL10 CXCL8 IFNG IL6
15
Show member pathways
12.23 CD14 CXCL8 IFNG IL6
16
Show member pathways
12.15 CD14 CXCL8 IL6
17 12.14 CD14 CXCL8 IL6
18 12.12 CD14 IFNG IL6
19
Show member pathways
12.09 CCL2 CCL5 CXCL10 CXCL8
20
Show member pathways
12.02 CD14 CXCL10 CXCL8 IFNG IL6
21
Show member pathways
12 CCL2 CCL5 CXCL8 IFNG IL6
22
Show member pathways
11.96 CD14 IFNG IL6
23
Show member pathways
11.95 CCL2 CCL5 CXCL10 CXCL8
24 11.92 CD14 IFNG IL6
25 11.91 CCL2 CXCL8 IL6
26 11.91 CCL2 CCL5 CXCL10 IL6
27 11.87 CXCL8 IFNG IL6
28 11.84 CCL2 CXCL8 IL6
29 11.83 CD14 CXCL8 IFNG IL6
30
Show member pathways
11.81 CD14 CXCL8 IL6
31 11.8 CCL2 CXCL10 CXCL8 IFNG IL6
32 11.77 CD14 CXCL8 IFNG IL6
33 11.74 CXCL8 IFNG IL6
34 11.7 CD14 CXCL8 IL6
35 11.69 CD14 IFNG IL6
36
Show member pathways
11.61 CXCL8 IFNG IL6
37 11.61 CCL2 CCL5 CXCL8 IFNG IL6
38 11.53 CXCL8 IFNG IL6
39 11.53 CD14 CXCL8 IL6
40 11.42 CCL2 CXCL8 IFNG IL6
41 11.4 CCL2 CCL5 CXCL10 IFNG IL6
42 11.31 CCL2 CXCL8 IL6
43 11.29 CXCL10 IFNG
44 11.26 IFNG IL6
45 11.26 CD14 IL6
46 11.26 CCL5 IL6
47 11.21 CCL2 CD14
48 11.21 IFNG IL6
49 11.17 IFNG IL6
50 11.15 CCL2 CCL5 CXCL8 IL6 SERPINA1

GO Terms for Viral Meningitis

Cellular components related to Viral Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 CCL2 CCL5 CD14 CRP CXCL10 CXCL8
2 extracellular space GO:0005615 9.28 CCL2 CCL5 CD14 CRP CXCL10 CXCL8

Biological processes related to Viral Meningitis according to GeneCards Suite gene sharing:

(show all 35)
# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.84 CCL2 CD14 CXCL10 IFNG
2 defense response to virus GO:0051607 9.83 CXCL10 IFNG IL6
3 cellular response to tumor necrosis factor GO:0071356 9.8 CCL2 CCL5 CXCL8
4 cytokine-mediated signaling pathway GO:0019221 9.8 CCL2 CCL5 CXCL10 CXCL8 IL6
5 response to bacterium GO:0009617 9.77 CCL2 CD14 CXCL10
6 response to virus GO:0009615 9.76 CCL5 CXCL10 IFNG
7 chemotaxis GO:0006935 9.76 CCL2 CCL5 CXCL10 CXCL8
8 cell chemotaxis GO:0060326 9.74 CCL2 CCL5 CXCL10
9 cellular response to interleukin-1 GO:0071347 9.73 CCL2 CCL5 CXCL8
10 immune response GO:0006955 9.73 CCL2 CCL5 CXCL10 CXCL8 IFNG IL6
11 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.72 CCL5 IFNG IL6
12 humoral immune response GO:0006959 9.7 CCL2 IFNG IL6
13 monocyte chemotaxis GO:0002548 9.69 CCL2 CCL5 IL6
14 protein kinase B signaling GO:0043491 9.67 CCL2 CCL5
15 acute-phase response GO:0006953 9.67 CRP IL6 SERPINA1
16 neutrophil chemotaxis GO:0030593 9.67 CCL2 CCL5 CXCL10 CXCL8
17 lymphocyte chemotaxis GO:0048247 9.66 CCL2 CCL5
18 response to tumor necrosis factor GO:0034612 9.66 CCL5 CD14
19 positive regulation of JAK-STAT cascade GO:0046427 9.65 CCL5 IL6
20 leukocyte chemotaxis GO:0030595 9.65 CXCL10 CXCL8
21 lipopolysaccharide-mediated signaling pathway GO:0031663 9.65 CCL2 CCL5 CD14
22 eosinophil chemotaxis GO:0048245 9.64 CCL2 CCL5
23 positive regulation of monocyte chemotaxis GO:0090026 9.64 CCL5 CXCL10
24 positive regulation of T cell migration GO:2000406 9.63 CCL5 CXCL10
25 regulation of signaling receptor activity GO:0010469 9.63 CCL2 CCL5 CXCL10 CXCL8 IFNG IL6
26 macrophage chemotaxis GO:0048246 9.62 CCL2 CCL5
27 negative regulation of G protein-coupled receptor signaling pathway GO:0045744 9.62 CCL5 CXCL8
28 chemokine-mediated signaling pathway GO:0070098 9.62 CCL2 CCL5 CXCL10 CXCL8
29 PERK-mediated unfolded protein response GO:0036499 9.61 CCL2 CXCL8
30 response to molecule of bacterial origin GO:0002237 9.61 CD14 CXCL8
31 cellular response to fibroblast growth factor stimulus GO:0044344 9.61 CCL2 CCL5 CXCL8
32 neutrophil activation GO:0042119 9.6 CCL5 CXCL8
33 negative regulation of lipid storage GO:0010888 9.58 CRP IL6
34 cellular response to lipopolysaccharide GO:0071222 9.35 CCL2 CD14 CXCL10 CXCL8 IL6
35 inflammatory response GO:0006954 9.17 CCL2 CCL5 CD14 CRP CXCL10 CXCL8

Molecular functions related to Viral Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 9.26 CCL2 CCL5 CXCL10 CXCL8
2 CCR chemokine receptor binding GO:0048020 9.16 CCL2 CCL5
3 cytokine activity GO:0005125 9.1 CCL2 CCL5 CXCL10 CXCL8 IFNG IL6

Sources for Viral Meningitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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