MCID: VRL012
MIFTS: 46

Viral Meningitis

Categories: Ear diseases, Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Viral Meningitis

MalaCards integrated aliases for Viral Meningitis:

Name: Viral Meningitis 12 3 15 17 70 32
Meningitis, Viral 44
Meningitis Viral 54

Classifications:



External Ids:

Disease Ontology 12 DOID:10310
ICD9CM 34 047.9
MeSH 44 D008587
NCIt 50 C118298
SNOMED-CT 67 154321007
ICD10 32 A87 A87.9
UMLS 70 C0025297

Summaries for Viral Meningitis

CDC : 3 Viral meningitis is the most common type of meningitis, an inflammation of the lining of the brain and spinal cord. It is often less severe than bacterial meningitis, and most people get better on their own (without treatment). However, anyone with symptoms of meningitis should see a doctor right away because some types of meningitis can be very serious. Only a doctor can determine if someone has meningitis, what is causing it, and the best treatment. Babies younger than 1 month old and people with weakened immune systems are more likely to have severe illness from viral meningitis.

MalaCards based summary : Viral Meningitis, also known as meningitis, viral, is related to aseptic meningitis and meningitis. An important gene associated with Viral Meningitis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include spinal cord, bone and brain, and related phenotypes are hematopoietic system and immune system

Disease Ontology : 12 A meningitis that has material basis in a viral infection.

Wikipedia : 73 Viral meningitis, also known as aseptic meningitis, is a type of meningitis due to a viral infection. It... more...

Related Diseases for Viral Meningitis

Diseases in the Meningitis family:

Viral Meningitis Chronic Meningitis
Bacterial Meningitis

Diseases related to Viral Meningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 525)
# Related Disease Score Top Affiliating Genes
1 aseptic meningitis 31.3 IFNG CXCL8 CRP CALCA ADA
2 meningitis 31.1 IL6 IFNG CXCL8 CRP CCL5 CCL2
3 encephalitis 30.6 IL6 CXCL10 CCL5 CCL2
4 bacterial meningitis 30.5 IL6 IFNG CXCL8 CRP CCL2
5 chickenpox 30.4 IL6 IFNG CRP ADA
6 meningoencephalitis 30.3 IL6 CXCL10 CRP CCL5
7 disease by infectious agent 30.3 SERPINA1 IL6 IFNG CRP
8 brain edema 30.2 IL6 IFNG CRP
9 tuberculous meningitis 30.2 CXCL8 CCL2 ADA
10 purpura 30.1 IL6 IFNG CRP
11 mumps 30.0 IL6 IFNG CXCL8 CXCL10
12 exanthem 29.9 IL6 IFNG CXCL8 CRP
13 miliary tuberculosis 29.9 IFNG CRP ADA
14 fungal meningitis 29.9 IL6 IFNG CXCL8
15 lymphopenia 29.7 IL6 IFNG ADA
16 sleep disorder 29.6 IL6 CXCL8 CRP
17 tetanus 29.6 IL6 IFNG CRP
18 bacterial infectious disease 29.5 IL6 IFNG CXCL8 CRP CD14 CCL2
19 chronic fatigue syndrome 29.4 IL6 IFNG CXCL8 CCL5
20 viral encephalitis 29.4 IL6 CXCL8 CXCL10 CCL5 CCL2
21 rhinitis 29.4 IL6 IFNG CXCL8 CCL5
22 leptospirosis 29.3 IL6 IFNG CXCL8 CRP CCL2
23 covid-19 29.1 IL6 CXCL8 CXCL10 CCL2
24 nervous system disease 29.0 IL6 IFNG CXCR3 CXCL8 CRP CCL2
25 dermatitis 28.9 IL6 IL16 IFNG CXCR3 CXCL8 CCL5
26 neuritis 28.5 IL6 IFNG CXCR3 CXCL8 CXCL10 CCL5
27 mollaret meningitis 11.0
28 lymphocytic choriomeningitis 10.5
29 scorpion envenomation 10.4 IL6 CCL5
30 cold agglutinin disease 10.4 IL6 CRP
31 prosthetic joint infection 10.4 IL6 CRP
32 sepsis in premature infants 10.4 CRP CALCA
33 viral laryngitis 10.4 SERPINA1 CRP
34 petrositis 10.4 IFNG CRP
35 near-fatal asthma 10.4 CCL5 CCL2
36 uremic pruritus 10.4 IL6 CRP
37 systemic autoimmune disease 10.4 IL6 CRP
38 cryopyrin-associated periodic syndrome 10.4 IL6 CRP
39 obesity-hypoventilation syndrome 10.4 IL6 CCL5
40 nodular nonsuppurative panniculitis 10.4 SERPINA1 CRP
41 allergic encephalomyelitis 10.4 CCL5 CCL2
42 panophthalmitis 10.4 IFNG CRP
43 b-cell growth factor 10.4 IL6 IFNG
44 xanthogranulomatous pyelonephritis 10.4 CRP CCL2
45 spotted fever rickettsiosis 10.4 IFNG CCL5
46 meningitis and encephalitis 10.4
47 skeletal tuberculosis 10.3 IFNG CRP
48 external ear carcinoma 10.3 CRP CALCA
49 bullous impetigo 10.3 IL6 CALCA
50 ulcer of lower limbs 10.3 IL6 CCL5

Comorbidity relations with Viral Meningitis via Phenotypic Disease Network (PDN):


Acute Cystitis Hypertension, Essential

Graphical network of the top 20 diseases related to Viral Meningitis:



Diseases related to Viral Meningitis

Symptoms & Phenotypes for Viral Meningitis

MGI Mouse Phenotypes related to Viral Meningitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.65 ADA CCL5 CD14 CXCL10 CXCR3 IFNG
2 immune system MP:0005387 9.44 ADA CCL2 CCL5 CD14 CRP CXCL10

Drugs & Therapeutics for Viral Meningitis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Role of CSF-CRPand Serum Procalcitonin in Differentiation Between Bacterial and Viral Meningitis in Children Unknown status NCT03387969
2 Danish Study Group of Infections of the Brain: A Nationwide Prospective Observational Cohort Study of All Central Nervous System Infections in Adults at Departments of Infectious Diseases in Denmark Recruiting NCT03418441
3 Coordination of Rare Diseases at Sanford Recruiting NCT01793168
4 A Comparison Between a New Experimental Enzymatic Assay to Real Time PCR for the Diagnosing of Central Nervous System Enteroviral Infection Withdrawn NCT00864903

Search NIH Clinical Center for Viral Meningitis

Cochrane evidence based reviews: meningitis, viral

Genetic Tests for Viral Meningitis

Anatomical Context for Viral Meningitis

MalaCards organs/tissues related to Viral Meningitis:

40
Spinal Cord, Bone, Brain, Skin, Lung, Lymph Node, Heart

Publications for Viral Meningitis

Articles related to Viral Meningitis:

(show top 50) (show all 1068)
# Title Authors PMID Year
1
Cerebrospinal fluid hepatocyte growth factor level in meningitis. 54 61
18787736 2008
2
Viral loads of cerebrospinal fluid in infants with enterovirus meningitis. 61 54
18484653 2008
3
[Expression of inflammatory mediators in meningitis]. 61 54
17760391 2007
4
[Differential diagnosis of bacterial and viral meningitis in childhood acute meningitis: a statistical model]. 54 61
17427553 2007
5
Adult meningism and viral meningitis, 1997-2004: clinical data and cerebrospinal fluid cytokines. 61 54
17139119 2006
6
High concentrations of the melatonin metabolite, N1-acetyl-N2-formyl-5-methoxykynuramine, in cerebrospinal fluid of patients with meningitis: a possible immunomodulatory mechanism. 61 54
16150112 2005
7
Serum procalcitonin and cerebrospinal fluid cytokines level in children with meningitis. 61 54
15545058 2004
8
[Concentration of proinflammatory cytokines (TNF-alpha, IL-8) in the cerebrospinal fluid and the course of bacterial meningitis]. 54 61
15230146 2004
9
Cytokine profile in cerebrospinal fluid of children with echovirus type 4 meningitis. 54 61
14643393 2003
10
New and old diagnostic markers of meningitis in cerebrospinal fluid (CSF). 61 54
12909299 2003
11
[Acute meningitidis, acute phase proteins and procalcitonin]. 54 61
12702467 2003
12
Direct and mononuclear cell mediated effects on interleukin 6 production by glioma cells in infection with herpes simplex virus type 1. 61 54
11170066 2001
13
Levels of three inflammation markers, C-reactive protein, serum amyloid A protein and procalcitonin, in the serum and cerebrospinal fluid of patients with meningitis. 54 61
11763415 2001
14
[Rapid diagnosis of the type of meningitis (bacterial or viral) by the assay of serum procalcitonin]. 54 61
10776411 2000
15
C-reactive protein is useful in distinguishing Gram stain-negative bacterial meningitis from viral meningitis in children. 61 54
10356141 1999
16
[Levels of interleukin-6 in cerebrospinal fluid of patients with meningitis]. 61 54
11107582 1999
17
[Quantitative levels of serum amyloid A protein and other proteins in cerebrospinal fluid and serum of patients with meningitis]. 54 61
9800479 1998
18
[Procalcitonin, C-reactive protein and interleukin 6 in bacterial and viral meningitis in children]. 54 61
9767794 1998
19
Chemokines and chemotaxis of leukocytes in infectious meningitis. 54 61
9626995 1998
20
Levels of interleukin-6, CRP and alpha 2 macroglobulin in cerebrospinal fluid (CSF) and serum as indicator of blood-CSF barrier damage. 61 54
9350334 1997
21
Chemotactic activity on mononuclear cells in the cerebrospinal fluid of patients with viral meningitis is mediated by interferon-gamma inducible protein-10 and monocyte chemotactic protein-1. 54 61
9368600 1997
22
[Beta 2 microglobulin in children with neuroinfections]. 61 54
9562796 1997
23
Acute phase proteins in serum and cerebrospinal fluid in the course of bacterial meningitis. 54 61
8521602 1995
24
Cerebrospinal fluid interleukin-6 and its diagnostic value in the investigation of meningitis. 61 54
7632033 1995
25
[The value of C-reactive protein for the differentiation of bacterial meningitis from viral meningitis]. 54 61
9524672 1995
26
The use of cytokine and C-reactive protein measurements in cerebrospinal fluid during acute infective meningitis. 54 61
8067666 1994
27
High concentrations of intrathecal interleukin-6 in human bacterial and nonbacterial meningitis. 61 54
1634815 1992
28
Interleukin-8 is produced in neoplastic and infectious diseases of the human central nervous system. 61 54
1643627 1992
29
The value of CSF adenosine deaminase levels in the differential diagnosis of childhood meningitis. 54 61
1440956 1992
30
Cerebrospinal fluid interleukin-6 and IgE in bacterial and viral meningitis. 54 61
1580206 1992
31
Cerebrospinal fluid levels of IL-6 in patients with acute infections of the central nervous system. 61 54
1287813 1992
32
Diagnostic value of cerebrospinal fluid adenosine deaminase determination. 61 54
2028233 1991
33
The research progresses and future prospects of Tetrastigma hemsleyanum Diels et Gilg: A valuable Chinese herbal medicine. 61
33465440 2021
34
Cerebrospinal Fluid Analysis. 61
33788511 2021
35
Artificial Intelligence in Differential Diagnostics of Meningitis: A Nationwide Study. 61
33800653 2021
36
The Epidemiology of Meningitis in Infants under 90 Days of Age in a Large Pediatric Hospital. 61
33806478 2021
37
A young man presenting with encephalopathy and seizures secondary to SARS-CoV-2. 61
33762283 2021
38
YouTube as a source of patient information for meningitis: A content-quality and audience engagement analysis. 61
33497948 2021
39
Cerebrospinal fluid type I interferon and cytokine profiles in enteroviral meningitis according to the presence or absence of pleocytosis. 61
33707153 2021
40
Delayed diagnosis of bilateral subdural effusions complicating intracranial hypotension in a patient presenting with post lumbar puncture headache. 61
33547096 2021
41
Viral Meningitis Associated With COVID-19 in a 9-year-old Child: A Case Report. 61
33181787 2021
42
Viral meningitis: an overview. 61
33392820 2021
43
Real-World Experience of Safety of Mycophenolate Mofetil in 119 Japanese Patients with Systemic Lupus Erythematosus: A Retrospective Single-Center Study. 61
33564682 2021
44
Cryptococcal meningitis: a review for emergency clinicians. 61
33420904 2021
45
Viral Etiologies of Meningitis in Patients with Presumed Pyogenic Meningitis at University Hospitals in Ethiopia. 61
33762832 2021
46
Evidence of SARS-CoV2 Entry Protein ACE2 in the Human Nose and Olfactory Bulb. 61
33486479 2021
47
Machine-Learning-Based Approach to Differential Diagnosis in Tuberculous and Viral Meningitis. 61
33538134 2020
48
Efficacy of auditory evoked potential follow-up in viral meningitis of infants. 61
32388814 2020
49
Pregabalin-associated stuttering and frequent blepharospasm: case report and review. 61
32632575 2020
50
Cerebrospinal Fluid Lactate as a Prognostic Marker of Disease Severity and Mortality in Cryptococcal Meningitis. 61
33249459 2020

Variations for Viral Meningitis

Expression for Viral Meningitis

Search GEO for disease gene expression data for Viral Meningitis.

Pathways for Viral Meningitis

Pathways related to Viral Meningitis according to GeneCards Suite gene sharing:

(show all 47)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.88 TIMP2 SERPINA1 MMP3 MMP1 IL6 IL16
2
Show member pathways
13.77 TIMP2 IL6 IL16 CXCR3 CXCL8 CXCL10
3
Show member pathways
13.63 IL6 IL16 IFNG CXCR3 CXCL8 CXCL10
4
Show member pathways
13.48 TIMP2 IL6 IL16 IFNG CXCL8 CCL5
5
Show member pathways
13.38 TIMP2 IL6 IL16 CXCR3 CXCL8 CXCL10
6
Show member pathways
13.35 MMP3 MMP1 CXCR3 CXCL8 CXCL10 CCL5
7
Show member pathways
13.3 MMP3 MMP1 IL6 IL16 IFNG CXCL8
8
Show member pathways
13.25 TIMP2 IL6 IL16 CXCR3 CXCL8 CXCL10
9
Show member pathways
13.02 MMP3 MMP1 IL6 IFNG CXCL8 CXCL10
10
Show member pathways
12.84 CXCR3 CXCL8 CXCL10 CCL5 CCL2
11
Show member pathways
12.8 IL6 IFNG CXCL8 CXCL10 CCL5 CCL2
12 12.51 IFNG CXCL10 CCL5 CCL2
13
Show member pathways
12.32 IL6 IFNG CRP CCL5 CCL2
14
Show member pathways
12.27 IL6 IFNG CXCL8 CD14
15
Show member pathways
12.25 TIMP2 IL6 IL16 IFNG CXCL8
16 12.24 MMP3 IL6 CXCL8 CD14
17
Show member pathways
12.22 IL6 CXCR3 CXCL8 CXCL10 CCL5 CCL2
18 12.21 IL6 CXCL8 CCL5 CCL2
19
Show member pathways
12.18 IL6 IFNG CXCL8 CXCL10 CD14
20
Show member pathways
12.03 MMP3 MMP1 IL6 IFNG CXCL8 CXCL10
21 11.99 IL6 IFNG CXCL8 CXCL10 CCL2
22 11.95 MMP3 MMP1 IL6 CXCL8 CCL2
23 11.93 IL6 IFNG CXCL8 CD14
24 11.9 IL6 IFNG CXCL8
25 11.9 MMP3 IL6 CXCL10 CCL5 CCL2
26 11.87 IL6 CXCL8 CCL2
27
Show member pathways
11.86 TIMP2 MMP3 MMP1
28
Show member pathways
11.83 IL6 CXCL8 CD14
29 11.81 TIMP2 MMP3 CCL2
30 11.81 MMP1 IL6 IFNG CXCL8
31 11.73 IL6 CXCL8 CD14
32 11.71 IL6 IFNG CD14
33 11.66 TIMP2 MMP3 MMP1 CXCL8
34 11.59 IL6 CXCL8 CD14
35 11.57 IL6 IFNG CXCL8
36 11.56 IL6 IFNG CXCL8 CCL2
37 11.53 MMP1 IL6 CXCL8
38
Show member pathways
11.52 MMP3 MMP1 IL6 IFNG CXCL8
39 11.47 IL6 IFNG CALCA
40 11.42 TIMP2 MMP3 MMP1 CCL5
41 11.34 IL6 CXCL8 CXCL10 CCL5 CCL2
42 11.27 MMP1 IL6 CXCL8 CCL2
43 11.23 SERPINA1 IL6 CXCL8 CCL5 CCL2 CALCA
44 11.2 TIMP2 IFNG CCL2
45 11.14 MMP3 MMP1 IL6 IFNG CXCL8 CCL5
46 11.06 IL6 CXCL8 CRP
47 10.99 TIMP2 IL6 IL16 CXCL8 CXCL10 CCL5

GO Terms for Viral Meningitis

Cellular components related to Viral Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 TIMP2 SERPINA1 MMP3 MMP1 IL6 IL16
2 extracellular space GO:0005615 9.47 TIMP2 SERPINA1 MMP3 IL6 IL16 IFNG

Biological processes related to Viral Meningitis according to GeneCards Suite gene sharing:

(show all 39)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.91 SERPINA1 MMP1 IL6 CALCA
2 cell surface receptor signaling pathway GO:0007166 9.85 IFNG CXCR3 CXCL10 CD14 CCL2
3 positive regulation of interleukin-6 production GO:0032755 9.83 IL6 IL16 IFNG
4 positive regulation of tumor necrosis factor production GO:0032760 9.81 IL6 IFNG CD14
5 cell chemotaxis GO:0060326 9.81 CXCR3 CCL5 CCL2
6 cellular response to tumor necrosis factor GO:0071356 9.81 CXCL8 CCL5 CCL2 CALCA
7 cellular response to interleukin-1 GO:0071347 9.8 CXCL8 CCL5 CCL2
8 cellular response to lipopolysaccharide GO:0071222 9.8 IL6 CXCL8 CXCL10 CD14 CCL2
9 regulation of insulin secretion GO:0050796 9.79 IL6 IFNG CCL5
10 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.79 IL6 IFNG CCL5
11 extracellular matrix disassembly GO:0022617 9.77 TIMP2 MMP3 MMP1
12 immune response GO:0006955 9.76 IL6 IL16 IFNG CXCR3 CXCL8 CXCL10
13 positive regulation of interleukin-8 production GO:0032757 9.74 IL6 CD14 CALCA
14 humoral immune response GO:0006959 9.73 IL6 IFNG CCL2
15 neutrophil chemotaxis GO:0030593 9.73 CXCL8 CXCL10 CCL5 CCL2
16 chemotaxis GO:0006935 9.73 IL16 CXCR3 CXCL8 CXCL10 CCL5 CCL2
17 positive regulation of protein complex assembly GO:0031334 9.72 MMP3 MMP1 IFNG
18 chemokine-mediated signaling pathway GO:0070098 9.72 CXCR3 CXCL8 CXCL10 CCL5 CCL2
19 acute-phase response GO:0006953 9.71 SERPINA1 IL6 CRP
20 induction of positive chemotaxis GO:0050930 9.68 IL16 CXCL8
21 macrophage chemotaxis GO:0048246 9.68 CCL5 CCL2
22 positive regulation of leukocyte chemotaxis GO:0002690 9.67 IL6 CXCL10
23 negative regulation of G protein-coupled receptor signaling pathway GO:0045744 9.67 CXCL8 CCL5
24 neutrophil activation GO:0042119 9.67 CXCL8 CCL5
25 cellular response to fibroblast growth factor stimulus GO:0044344 9.67 CXCL8 CCL5 CCL2
26 monocyte chemotaxis GO:0002548 9.67 IL6 CCL5 CCL2 CALCA
27 PERK-mediated unfolded protein response GO:0036499 9.66 CXCL8 CCL2
28 T cell chemotaxis GO:0010818 9.66 CXCR3 CXCL10
29 regulation of neuroinflammatory response GO:0150077 9.65 MMP3 IL6
30 cellular response to UV-A GO:0071492 9.65 MMP3 MMP1
31 lipopolysaccharide-mediated signaling pathway GO:0031663 9.65 CD14 CCL5 CCL2
32 response to molecule of bacterial origin GO:0002237 9.64 CXCL8 CD14
33 negative regulation of lipid storage GO:0010888 9.62 IL6 CRP
34 positive regulation of NMDA glutamate receptor activity GO:1904783 9.59 IFNG CCL2
35 positive regulation of interleukin-1 alpha production GO:0032730 9.58 IL16 CALCA
36 germinal center B cell differentiation GO:0002314 9.58 IL6 ADA
37 cytokine-mediated signaling pathway GO:0019221 9.56 MMP3 MMP1 IL6 IL16 CXCL8 CXCL10
38 positive regulation of cellular biosynthetic process GO:0031328 9.52 CXCL8 CCL5
39 inflammatory response GO:0006954 9.28 IL6 CXCR3 CXCL8 CXCL10 CRP CD14

Molecular functions related to Viral Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 9.26 CXCL8 CXCL10 CCL5 CCL2
2 cytokine activity GO:0005125 9.17 IL6 IL16 IFNG CXCL8 CXCL10 CCL5
3 CXCR chemokine receptor binding GO:0045236 9.16 CXCL8 CXCL10

Sources for Viral Meningitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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