MCID: VRL012
MIFTS: 47

Viral Meningitis

Categories: Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Viral Meningitis

MalaCards integrated aliases for Viral Meningitis:

Name: Viral Meningitis 12 15 17 74 3
Meningitis, Viral 45
Meningitis Viral 56

Classifications:



External Ids:

Disease Ontology 12 DOID:10310
ICD9CM 36 047.9
MeSH 45 D008587
NCIt 51 C118298
SNOMED-CT 69 58170007
ICD10 34 A87 A87.9
UMLS 74 C0025297

Summaries for Viral Meningitis

CDC : 3 Viral meningitis is the most common type of meningitis, an inflammation of the tissue that covers the brain and spinal cord. It is often less severe than bacterial meningitis, and most people get better on their own (without treatment). However, it’s very important for anyone with symptoms of meningitis to see a healthcare provider right away because some types of meningitis can be very serious. Only a doctor can determine if you have the disease, the type of meningitis, and the best treatment, which can sometimes be lifesaving. Babies younger than 1 month old and people with weakened immune systems are more likely to have severe illness from viral meningitis.

MalaCards based summary : Viral Meningitis, also known as meningitis, viral, is related to aseptic meningitis and meningitis. An important gene associated with Viral Meningitis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. Affiliated tissues include brain, spinal cord and t cells, and related phenotype is immune system.

Disease Ontology : 12 A meningitis that has material basis in a viral infection.

Wikipedia : 77 Viral meningitis, also known as aseptic meningitis, is a type of meningitis due to a viral infection. It... more...

Related Diseases for Viral Meningitis

Diseases in the Meningitis family:

Viral Meningitis Chronic Meningitis
Bacterial Meningitis

Diseases related to Viral Meningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 244)
# Related Disease Score Top Affiliating Genes
1 aseptic meningitis 32.7 CXCL8 IFNG
2 meningitis 31.5 CCL2 CRP CXCL8 IFNG IL6
3 encephalitis 30.4 CCL2 CCL5 CXCL10
4 tuberculous meningitis 29.9 CCL2 CXCL8
5 bacterial meningitis 29.8 CRP CXCL8 IL6
6 viral infectious disease 29.4 CCL5 CXCL10 CXCL8 IFNG IL6
7 viral encephalitis 28.3 CCL2 CCL5 CXCL10 CXCL8 IL6
8 mollaret meningitis 11.1
9 lymphocytic choriomeningitis 10.6
10 panniculitis 10.4 IFNG SERPINA1
11 eumycotic mycetoma 10.4 CCL5 IFNG
12 folliculitis 10.4 CCL5 IFNG
13 orofacial granulomatosis 10.3 CCL5 IFNG
14 pharyngitis 10.3 CRP CXCL8
15 septic arthritis 10.3 CRP CXCL8
16 wells syndrome 10.3 CRP CXCL8
17 inclusion conjunctivitis 10.3 CCL5 IL16
18 nonspecific interstitial pneumonia 10.3 CCL2 IFNG
19 mycetoma 10.3 CCL5 CXCL8
20 african tick-bite fever 10.3 CCL5 IFNG
21 myasthenic syndrome, congenital, 1a, slow-channel 10.2 CRP CXCL8
22 japanese encephalitis 10.2 CCL5 CXCL10
23 macular holes 10.2 CCL2 CXCL8
24 mycobacterium chelonae 10.2 CD14 CXCL8
25 pyuria 10.2 CRP CXCL8
26 whiplash 10.2 CCL5 IL16
27 meningitis and encephalitis 10.2
28 mycobacterium kansasii 10.2 CD14 CXCL8
29 cardiac rupture 10.2 CRP CXCL8
30 vulvovaginitis 10.2 CCL5 CXCL8
31 tuberculous peritonitis 10.2 CRP IFNG
32 periapical granuloma 10.1 CCL5 CXCL8
33 herpes simplex virus keratitis 10.1 CCL2 CXCL8
34 apnea, obstructive sleep 10.1 CRP IL6
35 prediabetes syndrome 10.1 CRP IL6
36 vasculitis 10.1 CCL2 CRP SERPINA1
37 intermittent explosive disorder 10.1 CRP IL6
38 adult-onset still's disease 10.1 CRP IL6
39 hypersensitivity reaction type iii disease 10.1 CRP IL6
40 intermediate coronary syndrome 10.1 CRP IL6
41 systolic heart failure 10.1 CRP IL6
42 mycobacterium abscessus 10.1 CXCL8 SERPINA1
43 polyarteritis nodosa 10.1 CRP IL6
44 israeli tick typhus 10.1 CCL2 CXCL8
45 transient arthritis 10.1 IL6 SERPINA1
46 status asthmaticus 10.1 CCL5 CXCL8
47 glaucomatocyclitic crisis 10.1 CXCL10 CXCL8
48 fibromyalgia 10.1 IL6 SERPINA1
49 clonorchiasis 10.1 CXCL8 IFNG
50 acute cervicitis 10.1 CCL5 CXCL10

Comorbidity relations with Viral Meningitis via Phenotypic Disease Network (PDN):


Acute Cystitis Hypertension, Essential

Graphical network of the top 20 diseases related to Viral Meningitis:



Diseases related to Viral Meningitis

Symptoms & Phenotypes for Viral Meningitis

MGI Mouse Phenotypes related to Viral Meningitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.23 CCL2 CCL5 CD14 CRP CXCL10 IFNG

Drugs & Therapeutics for Viral Meningitis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Long Term Outcomes of EV71 CNS Infection Unknown status NCT00172393
2 Procalcitonin (PCT) as a Diagnostic Marker of Bacterial Infection in the Patients Admitted for Fever and/or Inflammatory Syndrome to the Internal Medicine Department Completed NCT02898948
3 Central Nervous System Infections in Denmark Recruiting NCT03418441
4 Role of CSF-CRPand Serum Procalcitonin in Differentiation Between Bacterial and Viral Meningitis in Children Not yet recruiting NCT03387969
5 A New Enzymatic Assay for Rapid Diagnosing of Central Nervous System Enteroviral Infection Withdrawn NCT00864903

Search NIH Clinical Center for Viral Meningitis

Cochrane evidence based reviews: meningitis, viral

Genetic Tests for Viral Meningitis

Anatomical Context for Viral Meningitis

MalaCards organs/tissues related to Viral Meningitis:

42
Brain, Spinal Cord, T Cells, Testes, Neutrophil, Monocytes, B Cells

Publications for Viral Meningitis

Articles related to Viral Meningitis:

(show top 50) (show all 171)
# Title Authors Year
1
A study on correlations of procalcitonin and interleukin-6 with viral meningitis. ( 29917201 )
2018
2
Cerebrospinal fluid monocytes in bacterial meningitis, viral meningitis, and neuroborreliosis. ( 29628177 )
2018
3
Cerebrospinal Fluid Concentrations of Biogenic Amines: Potential Biomarkers for Diagnosis of Bacterial and Viral Meningitis. ( 29652804 )
2018
4
Incidence, aetiology, and sequelae of viral meningitis in UK adults: a multicentre prospective observational cohort study. ( 30153934 )
2018
5
Viral meningitis in the UK: time to speed up. ( 30153931 )
2018
6
Molecular investigations of viral meningitis among HIV-infected adults in Accra, Ghana. ( 30153867 )
2018
7
Comparison of C Reactive Protein and Procalcitonin Levels in Cerebrospinal Fluid and Serum to Differentiate Bacterial from Viral Meningitis. ( 30143494 )
2018
8
A New Scoring System for the Differential Diagnosis between Tuberculous Meningitis and Viral Meningitis. ( 30069169 )
2018
9
Viral Meningitis and Encephalitis. ( 30273240 )
2018
10
Cerebrospinal fluid lactate: a differential biomarker for bacterial and viral meningitis in children. ( 28866321 )
2017
11
With a little help from a computer: discriminating between bacterial and viral meningitis based on dominance-based rough set approach analysis. ( 28796045 )
2017
12
Viral meningitis: current issues in diagnosis and treatment. ( 28118219 )
2017
13
Etiological agents of viral meningitis in children from a dengue-endemic area, Southeast region of Brazil. ( 28320174 )
2017
14
Cerebrospinal fluid metabolomic profiling in tuberculous and viral meningitis: Screening potential markers for differential diagnosis. ( 28063937 )
2017
15
Diagnostic value of lactate, procalcitonin, ferritin, serum-C-reactive protein, and other biomarkers in bacterial and viral meningitis: A cross-sectional study. ( 28858084 )
2017
16
Viral meningitis: epidemiology and diagnosis. ( 27527750 )
2016
17
The usefulness of serum delta neutrophil index for differentiating bacterial and viral meningitis in the emergency department. ( 27752624 )
2016
18
Cerebrospinal fluid ferritin and albumin index: potential candidates for scoring system to differentiate between bacterial and viral meningitis in children. ( 26999689 )
2016
19
Predominance of enterovirus B and echovirus 30 as cause of viral meningitis in a UK population. ( 27367546 )
2016
20
Hospital admissions for viral meningitis in children in England over five decades: a population-based observational study. ( 27527749 )
2016
21
Meningitis retention syndrome: An unusual complication of viral meningitis. ( 27841204 )
2016
22
Procalcitonin as a Serum Biomarker for Differentiation of Bacterial Meningitis From Viral Meningitis in Children: Evidence From a Meta-Analysis. ( 26378091 )
2015
23
Viral Meningitis Epidemics and a Single, Recent, Recombinant and Anthroponotic Origin of Swine Vesicular Disease Virus. ( 26508717 )
2015
24
Restricted diffusion of the splenium of the corpus callosum in viral meningitis. ( 24707341 )
2014
25
Cerebral microbleeding in varicella-zoster viral meningitis: an early sign of vasculopathy? ( 24463624 )
2014
26
Confirmed viral meningitis with normal CSF findings. ( 25035443 )
2014
27
Time trends of viral meningitis among young adults in Israel: 1978-2012. ( 24463724 )
2014
28
Molecular characterisation of enteroviruses and clinical findings from a cluster of paediatric viral meningitis cases in Tshwane, South Africa 2010-2011. ( 25176522 )
2014
29
Underreporting of viral encephalitis and viral meningitis, Ireland, 2005-2008. ( 23965781 )
2013
30
Comparison of cytokine gene polymorphisms among Greek patients with invasive meningococcal disease or viral meningitis. ( 23378564 )
2013
31
Viral meningitis and encephalitis. ( 23981453 )
2013
32
Detection of herpes viruses in the cerebrospinal fluid of adults with suspected viral meningitis in Malawi. ( 22798048 )
2013
33
Viral meningitis admitted to an infectious diseases hospital: a retrospective case series. ( 24340533 )
2013
34
Trends in the management of viral meningitis at United States children's hospitals. ( 23530164 )
2013
35
Herpes zoster as a cause of viral meningitis in immunocompetent patients. ( 23307457 )
2013
36
Viral meningitis, active and reserve components, U.S. Armed Forces, 2002-2011. ( 22963254 )
2012
37
Impact of polymerase chain reaction results on patient management during a viral meningitis outbreak in Tropical North Queensland. ( 22313560 )
2012
38
Epidemics of viral meningitis caused by echovirus 6 and 30 in Korea in 2008. ( 22336050 )
2012
39
Vogt-Koyanagi-Harada syndrome: a rare but important differential diagnosis of viral meningitis. ( 21905951 )
2012
40
Acute bacterial and viral meningitis. ( 23221840 )
2012
41
Clinical prediction rule for differentiating tuberculous from viral meningitis. ( 22507645 )
2012
42
Viral meningitis: which patients can be discharged from the emergency department? ( 22709622 )
2012
43
Vertebral artery dissection associated with viral meningitis. ( 22909191 )
2012
44
Lumbar puncture is not needed for all patients suspected to have viral meningitis. ( 22340799 )
2012
45
Performance of thirteen clinical rules to distinguish bacterial and presumed viral meningitis in Vietnamese children. ( 23209715 )
2012
46
Patient Education Series. Viral meningitis in adults. ( 21403505 )
2011
47
A dural arteriovenous fistula in cavernous sinus developed from viral meningitis. ( 21748936 )
2011
48
Descriptive analysis of viral meningitis in a general hospital: differences in the characteristics between children and adults. ( 21349608 )
2011
49
Review of the etiologies of viral meningitis and encephalitis in a dengue endemic region. ( 21292281 )
2011
50
Cytokine and adhesion molecule expression evolves between the neutrophilic and lymphocytic phases of viral meningitis. ( 20626298 )
2010

Variations for Viral Meningitis

Expression for Viral Meningitis

Search GEO for disease gene expression data for Viral Meningitis.

Pathways for Viral Meningitis

Pathways related to Viral Meningitis according to GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.8 CCL2 CCL5 CD14 CRP CXCL10 CXCL8
2
Show member pathways
13.55 CCL2 CCL5 CD14 CXCL10 CXCL8 IFNG
3
Show member pathways
13.41 CCL2 CCL5 CXCL8 IFNG IL16 IL6
4
Show member pathways
13.28 CCL2 CCL5 CXCL10 CXCL8 IL16 IL6
5
Show member pathways
13.25 CCL2 CCL5 CXCL10 CXCL8 IFNG IL16
6
Show member pathways
13.18 CCL2 CCL5 CXCL10 CXCL8 IL16 IL6
7
Show member pathways
12.97 CCL2 CCL5 CD14 CXCL10 CXCL8 IFNG
8
Show member pathways
12.76 CCL2 CCL5 CXCL10 CXCL8
9
Show member pathways
12.64 CCL5 CD14 CXCL10 CXCL8 IFNG IL6
10
Show member pathways
12.5 CCL2 CD14 IFNG IL6
11 12.48 CCL2 CCL5 CXCL10 IFNG
12
Show member pathways
12.48 CCL2 CCL5 CXCL10 CXCL8 IFNG IL6
13
Show member pathways
12.28 CCL2 CCL5 CRP IFNG IL6
14
Show member pathways
12.27 CCL2 CXCL10 CXCL8 IFNG IL6
15
Show member pathways
12.24 CD14 CXCL8 IFNG IL6
16
Show member pathways
12.18 CXCL8 IFNG IL16 IL6
17
Show member pathways
12.16 CD14 CXCL8 IL6
18 12.15 CD14 CXCL8 IL6
19 12.12 CD14 IFNG IL6
20
Show member pathways
12.11 CCL2 CCL5 CXCL10 CXCL8
21
Show member pathways
12.07 CD14 CXCL10 CXCL8 IFNG IL6
22
Show member pathways
11.97 CCL2 CCL5 CXCL10 CXCL8
23
Show member pathways
11.96 CD14 IFNG IL6
24 11.93 CD14 IFNG IL6
25 11.93 CCL2 CCL5 CXCL10 IL6
26
Show member pathways
11.92 CCL2 CCL5 CXCL8 IFNG IL16 IL6
27 11.91 CCL2 CXCL8 IL6
28 11.88 CXCL8 IFNG IL6
29 11.86 CD14 CXCL8 IFNG IL6
30 11.85 CCL2 CXCL8 IL6
31 11.85 CCL2 CXCL10 CXCL8 IFNG IL6
32
Show member pathways
11.81 CD14 CXCL8 IL6
33 11.8 CD14 CXCL8 IFNG IL6
34 11.74 CXCL8 IFNG IL6
35 11.71 CD14 CXCL8 IL6
36 11.69 CD14 IFNG IL6
37 11.68 CCL2 CCL5 CXCL8 IFNG IL6
38
Show member pathways
11.61 CXCL8 IFNG IL6
39 11.54 CXCL8 IFNG IL6
40 11.54 CD14 CXCL8 IL6
41 11.51 CCL2 CCL5 CXCL10 IFNG IL6
42 11.47 CCL2 CXCL8 IFNG IL6
43 11.32 CCL2 CXCL8 IL6
44 11.29 IFNG IL6
45 11.26 CD14 IL6
46 11.26 CCL5 IL6
47 11.22 CCL2 CD14
48 11.22 IFNG IL6
49 11.17 IFNG IL6
50 11.15 CCL2 CCL5 CXCL8 IL6 SERPINA1

GO Terms for Viral Meningitis

Cellular components related to Viral Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 CCL2 CCL5 CD14 CRP CXCL10 CXCL8
2 extracellular space GO:0005615 9.32 CCL2 CCL5 CD14 CRP CXCL10 CXCL8

Biological processes related to Viral Meningitis according to GeneCards Suite gene sharing:

(show all 35)
# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.86 CCL2 CD14 CXCL10 IFNG
2 defense response to virus GO:0051607 9.83 CXCL10 IFNG IL6
3 cellular response to tumor necrosis factor GO:0071356 9.81 CCL2 CCL5 CXCL8
4 response to bacterium GO:0009617 9.78 CCL2 CD14 CXCL10
5 response to virus GO:0009615 9.77 CCL5 CXCL10 IFNG
6 cellular response to lipopolysaccharide GO:0071222 9.77 CCL2 CD14 CXCL10 CXCL8 IL6
7 cell chemotaxis GO:0060326 9.75 CCL2 CCL5 CXCL10
8 cellular response to interleukin-1 GO:0071347 9.74 CCL2 CCL5 CXCL8
9 neutrophil chemotaxis GO:0030593 9.73 CCL2 CCL5 CXCL10 CXCL8
10 cytokine-mediated signaling pathway GO:0019221 9.73 CCL2 CCL5 CXCL10 CXCL8 IL16 IL6
11 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.72 CCL5 IFNG IL6
12 chemotaxis GO:0006935 9.72 CCL2 CCL5 CXCL10 CXCL8 IL16
13 humoral immune response GO:0006959 9.71 CCL2 IFNG IL6
14 chemokine-mediated signaling pathway GO:0070098 9.71 CCL2 CCL5 CXCL10 CXCL8
15 monocyte chemotaxis GO:0002548 9.7 CCL2 CCL5 IL6
16 immune response GO:0006955 9.7 CCL2 CCL5 CXCL10 CXCL8 IFNG IL16
17 acute-phase response GO:0006953 9.69 CRP IL6 SERPINA1
18 lymphocyte chemotaxis GO:0048247 9.67 CCL2 CCL5
19 lipopolysaccharide-mediated signaling pathway GO:0031663 9.67 CCL2 CCL5 CD14
20 positive regulation of JAK-STAT cascade GO:0046427 9.65 CCL5 IL6
21 eosinophil chemotaxis GO:0048245 9.65 CCL2 CCL5
22 positive regulation of monocyte chemotaxis GO:0090026 9.65 CCL5 CXCL10
23 cellular response to fibroblast growth factor stimulus GO:0044344 9.65 CCL2 CCL5 CXCL8
24 positive regulation of T cell migration GO:2000406 9.64 CCL5 CXCL10
25 induction of positive chemotaxis GO:0050930 9.63 CXCL8 IL16
26 macrophage chemotaxis GO:0048246 9.63 CCL2 CCL5
27 leukocyte chemotaxis GO:0030595 9.63 CXCL10 CXCL8 IL16
28 negative regulation of G protein-coupled receptor signaling pathway GO:0045744 9.62 CCL5 CXCL8
29 PERK-mediated unfolded protein response GO:0036499 9.62 CCL2 CXCL8
30 response to molecule of bacterial origin GO:0002237 9.61 CD14 CXCL8
31 neutrophil activation GO:0042119 9.59 CCL5 CXCL8
32 negative regulation of lipid storage GO:0010888 9.58 CRP IL6
33 regulation of signaling receptor activity GO:0010469 9.5 CCL2 CCL5 CXCL10 CXCL8 IFNG IL16
34 response to tumor necrosis factor GO:0034612 9.36 CD14
35 inflammatory response GO:0006954 9.17 CCL2 CCL5 CD14 CRP CXCL10 CXCL8

Molecular functions related to Viral Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 9.26 CCL2 CCL5 CXCL10 CXCL8
2 cytokine activity GO:0005125 9.17 CCL2 CCL5 CXCL10 CXCL8 IFNG IL16
3 CCR chemokine receptor binding GO:0048020 9.16 CCL2 CCL5

Sources for Viral Meningitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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