MCID: VRL005
MIFTS: 42

Viral Pneumonia

Categories: Respiratory diseases, Infectious diseases

Aliases & Classifications for Viral Pneumonia

MalaCards integrated aliases for Viral Pneumonia:

Name: Viral Pneumonia 12 15
Pneumonia, Viral 44 73

Classifications:



External Ids:

Disease Ontology 12 DOID:10533
ICD10 33 J12.9 J12
ICD9CM 35 480 480.9
MeSH 44 D011024
UMLS 73 C0032310

Summaries for Viral Pneumonia

Disease Ontology : 12 A pneumonia described as an inflammatory illness of the lung commonly caused by viruses such as influenza virus, parainfluenza, adenovirus, rhinovirus, herpes simplex virus, respiratory syncytial virus, hantavirus, and cytomegalovirus.

MalaCards based summary : Viral Pneumonia, also known as pneumonia, viral, is related to pneumonia and malaria. An important gene associated with Viral Pneumonia is NSMCE3 (NSE3 Homolog, SMC5-SMC6 Complex Component), and among its related pathways/superpathways are Innate Immune System and Regulation of IFNA signaling. The drugs Acyclovir and Ganciclovir have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and bone.

Wikipedia : 76 Viral pneumonia is a pneumonia caused by a virus. Viruses are one of the two major causes of pneumonia,... more...

Related Diseases for Viral Pneumonia

Diseases in the Pneumonia family:

Viral Pneumonia

Diseases related to Viral Pneumonia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 142)
# Related Disease Score Top Affiliating Genes
1 pneumonia 32.0 CRP IL6 TLR9
2 malaria 27.8 CR1 CRP IL17A IL6 TLR9
3 influenza 11.3
4 lung disease, immunodeficiency, and chromosome breakage syndrome 10.9
5 cold agglutinin disease 10.7 CRP IL6
6 cryopyrin-associated periodic syndrome 10.7 CRP IL6
7 cardiogenic shock 10.7 CRP IL6
8 acute cholangitis 10.7 CRP IL6
9 neutrophilia, hereditary 10.7 CRP IL6
10 uremic pruritus 10.7 CRP IL6
11 spinal disease 10.7 CRP IL6
12 angina pectoris 10.7 CRP IL6
13 cecal disease 10.7 CRP IL6
14 relapsing polychondritis 10.7 CRP IL6
15 subacute thyroiditis 10.7 CRP IL6
16 intussusception 10.7 CRP IL6
17 louse-borne relapsing fever 10.7 CRP IL6
18 multicentric castleman disease 10.7 CRP IL6
19 hypersensitivity reaction type iii disease 10.7 CRP IL6
20 ischemic heart disease 10.7 CRP IL6
21 mesenteric lymphadenitis 10.7 CRP IL6
22 alexithymia 10.6 CRP IL6
23 intermittent explosive disorder 10.6 CRP IL6
24 intermediate coronary syndrome 10.6 CRP IL6
25 acute cystitis 10.6 CRP IL6
26 systolic heart failure 10.6 CRP IL6
27 polyarteritis nodosa 10.6 CRP IL6
28 prediabetes syndrome 10.6 CRP IL6
29 acute pyelonephritis 10.6 CRP IL6
30 apnea, obstructive sleep 10.6 CRP IL6
31 adult-onset still's disease 10.6 CRP IL6
32 viral meningitis 10.6 CRP IL6
33 infective endocarditis 10.6 CRP IL6
34 hemorrhagic fever with renal syndrome 10.6 CRP IL6
35 lymph node disease 10.6 CRP IL6
36 bladder disease 10.6 CRP IL6
37 intermittent claudication 10.6 CRP IL6
38 leptospirosis 10.6 CRP IL6
39 peripheral artery disease 10.6 CRP IL6
40 pericardial effusion 10.6 CRP IL6
41 proliferative glomerulonephritis 10.5 CR1 IL6
42 pancreas disease 10.5 CRP IL6
43 sleep disorder 10.5 CRP IL6
44 pericarditis 10.5 CRP IL6
45 transverse myelitis 10.5 IL17A IL6
46 reactive arthritis 10.5 CRP IL6
47 radiculopathy 10.5 IL17A IL6
48 brucellosis 10.5 CRP IL6
49 myelitis 10.5 IL17A IL6
50 stromal keratitis 10.5 IL17A IL6

Comorbidity relations with Viral Pneumonia via Phenotypic Disease Network (PDN):


Acute Cystitis Bronchitis
Chronic Myocardial Ischemia Deficiency Anemia
Familial Atrial Fibrillation Heart Disease
Hypothyroidism Ischemic Heart Disease
Postinflammatory Pulmonary Fibrosis Respiratory Failure

Graphical network of the top 20 diseases related to Viral Pneumonia:



Diseases related to Viral Pneumonia

Symptoms & Phenotypes for Viral Pneumonia

Drugs & Therapeutics for Viral Pneumonia

Drugs for Viral Pneumonia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 37)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acyclovir Approved Phase 4 59277-89-3 2022
2
Ganciclovir Approved, Investigational Phase 4 82410-32-0 3454
3
Oseltamivir Approved Phase 4 204255-11-8, 196618-13-0 65028
4 Anti-Infective Agents Phase 4,Phase 3,Not Applicable
5 Antiviral Agents Phase 4,Phase 3
6 Ganciclovir triphosphate Phase 4
7 Nucleic Acid Synthesis Inhibitors Phase 4
8 Anti-Bacterial Agents Phase 4,Not Applicable
9 Antibiotics, Antitubercular Phase 4
10 Antitubercular Agents Phase 4
11
Fluticasone Approved, Experimental, Investigational Phase 3 90566-53-3 62924
12
Hydrocortisone Approved, Vet_approved Phase 3 50-23-7 5754
13
Butyric Acid Experimental, Investigational Phase 3 107-92-6 264
14 Anti-Allergic Agents Phase 3
15 Anti-Asthmatic Agents Phase 3
16 Anti-Inflammatory Agents Phase 3
17 Autonomic Agents Phase 3
18 Bronchodilator Agents Phase 3
19 Dermatologic Agents Phase 3
20 Peripheral Nervous System Agents Phase 3
21 Respiratory System Agents Phase 3
22 Cortisol succinate Phase 3
23 Hydrocortisone 17-butyrate 21-propionate Phase 3
24 Hydrocortisone acetate Phase 3
25 Hydrocortisone-17-butyrate Phase 3
26
Azithromycin Approved Not Applicable 83905-01-5 55185 447043
27
Erythromycin Approved, Investigational, Vet_approved Not Applicable 114-07-8 12560
28
Nitric Oxide Approved 10102-43-9 145068 160954
29
Salmon Calcitonin Approved, Investigational 47931-85-1 16129616
30
Calcitonin gene-related peptide Investigational 83652-28-2
31 Cephalosporins Not Applicable
32 Erythromycin Estolate Not Applicable
33 Erythromycin Ethylsuccinate Not Applicable
34 Erythromycin stearate Not Applicable
35 Gastrointestinal Agents Not Applicable
36 Bone Density Conservation Agents
37 calcitonin

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 PTH - Preemptive Treatment for Herpesviridae Unknown status NCT02152358 Phase 4 Aciclovir;Ganciclovir;Placebo
2 Duration of Antibiotic Therapy in Community - Acquired Pneumonia Unknown status NCT01492387 Phase 4
3 Rapid Empiric Treatment With Oseltamivir Study (RETOS) Completed NCT01248715 Phase 4 oseltamivir
4 Inhaled Corticosteroids in U-5 Children With Acute Respiratory Infection in Uganda: A Randomised Trial Completed NCT01868113 Phase 3 Inhaled corticosteroid
5 A Study to Evaluate the Efficacy and Safety of Pimodivir in Combination With the Standard-of-Care Treatment in Adolescent, Adult, and Elderly Non-Hospitalized Participants With Influenza A Infection Who Are at Risk of Developing Complications Recruiting NCT03381196 Phase 3 Pimodivir 600 mg;Placebo
6 A Study to Evaluate the Efficacy and Safety of Pimodivir in Combination With the Standard-of-Care Treatment in Adolescent, Adult, and Elderly Hospitalized Participants With Influenza A Infection Recruiting NCT03376321 Phase 3 Pimodivir 600 mg;Placebo
7 Low Doses Corticosteroids as Adjuvant Therapy for the Treatment of Severe H1N1 Flu Terminated NCT01014364 Phase 3 hydrocortisone;isotonic saline
8 Use of TREM-1 Protein to Differentiate Viral and Bacterial Pneumonias in Intubated Children Unknown status NCT00645619
9 A Registry Study on Xiyanping(a Chinese Medicine Injection) Used in Fifty Hospitals Unknown status NCT01612572
10 The Impact of Simultaneous Presence of Viral and Bacterial Pathogens on Therapy and Course of Severe Pneumonia Unknown status NCT02203110
11 Effectiveness Study of Integrative Treatment for Pediatric Community Acquired Pneumonia Unknown status NCT02362906 Not Applicable Xiyanping injection;wind-heat formula granules;phlegm-heat formula granules;Fu-xiong San;second generation cephalosporin;Erythromycin;Azithromycin
12 Severe Pandemic H1N1 Infection in ICU: Comparative Resource Utilization Completed NCT01485237
13 Pneumonia in the Intensive Care Unit (ICU) Setting Completed NCT02685930
14 Long-term Outcome and Lung Capacity in Survivors of ARDS Due to Influenza A (H1N1) v2009 The RESPIFLU Study Completed NCT01271842
15 Procalcitonin Test for Differentiation of the Cause of Pneumonia Recruiting NCT03350802
16 Surveillance of Hospitalised Pneumonia and Bacterial Meningitis in Tône District, Togo, 2010-2013 Recruiting NCT01747369
17 Managing Bacterial Pneumonia in Children Without Antimicrobials Not yet recruiting NCT03256474
18 Clinical Pediatric Pneumonia Score in Critically Ill Children Withdrawn NCT02139384
19 Microbiology Testing With the Aim Of Directed Antimicrobial Therapy For CAP Withdrawn NCT01662258 Not Applicable

Search NIH Clinical Center for Viral Pneumonia

Cochrane evidence based reviews: pneumonia, viral

Genetic Tests for Viral Pneumonia

Anatomical Context for Viral Pneumonia

MalaCards organs/tissues related to Viral Pneumonia:

41
Lung, Testes, Bone, Neutrophil, Endothelial, Monocytes, Kidney

Publications for Viral Pneumonia

Articles related to Viral Pneumonia:

(show top 50) (show all 158)
# Title Authors Year
1
Hemorrhagic encephalitis associated with H3N2 influenza A viral pneumonia. ( 29440541 )
2018
2
Radiographic and CT Features of Viral Pneumonia. ( 29757717 )
2018
3
Application of extracorporeal membrane oxygenation in patients with severe acute respiratory distress syndrome induced by avian influenza A (H7N9) viral pneumonia: national data from the Chinese multicentre collaboration. ( 29310581 )
2018
4
Viral pneumonia: etiologies and treatment. ( 29680828 )
2018
5
Stewardship opportunities in viral pneumonia: why not the immunocompromised? ( 29423923 )
2018
6
Viral Pneumonia in Patients with Hematopoietic Cell Transplantation and Hematologic Malignancies. ( 28477640 )
2017
7
Does atopy affect the course of viral pneumonia? ( 28634031 )
2017
8
Retrospective review of epidemic viral pneumonia cases in Turkey: A multicenter study. ( 28413489 )
2017
9
Viral Pneumonia in Patients with Hematologic Malignancy or Hematopoietic Stem Cell Transplantation. ( 28159165 )
2017
10
Epidemiology of Viral Pneumonia. ( 28159152 )
2017
11
Secondary organizing pneumonia following viral pneumonia caused by severe influenza B: a case report and literature reviews. ( 28810835 )
2017
12
The impact of pneumococcal vaccination on bacterial and viral pneumonia in Western Australian children: record linkage cohort study of 469,589 births (1996-2012). ( 29069315 )
2017
13
Emodin Inhibition of Influenza A Virus Replication and Influenza Viral Pneumonia via the Nrf2, TLR4, p38/JNK and NF-kappaB Pathways. ( 29057806 )
2017
14
Severe viral pneumonia in adults: what is important for the ICU physician? ( 28633583 )
2017
15
Effect of low-to-moderate-dose corticosteroids on mortality of hospitalized adolescents and adults with influenza A(H1N1)pdm09 viral pneumonia. ( 28464462 )
2017
16
Bacterial and viral pneumonia: New insights from the Drakenstein Child Health Study. ( 28687247 )
2017
17
Vaccines in the Prevention of Viral Pneumonia. ( 28159157 )
2017
18
Viral Pneumonia and Acute Respiratory Distress Syndrome. ( 28159154 )
2017
19
Graft Loss and Clad Onset is Hastened by Viral Pneumonia After Lung Transplantation. ( 27467538 )
2016
20
Protective effects of Yinhuapinggan granule on mice with influenza viral pneumonia. ( 26655878 )
2016
21
Adjuvant Corticosteroid Treatment in Adults With Influenza A (H7N9) Viral Pneumonia. ( 26934144 )
2016
22
Epidemiology, Co-Infections, and Outcomes of Viral Pneumonia in Adults: An Observational Cohort Study. ( 26683973 )
2015
23
Impact of antibacterials on subsequent resistance and clinical outcomes in adult patients with viral pneumonia: an opportunity for stewardship. ( 26577540 )
2015
24
CAUSATIVE AGENTS OF SEVERE COMMUNITY ACQUIRED VIRAL PNEUMONIA AMONG CHILDREN IN EASTERN THAILAND. ( 26867384 )
2015
25
Review of Non-Bacterial Infections in Respiratory Medicine: Viral Pneumonia. ( 25957460 )
2015
26
The Serum Value of NO and IL-17 were Increased in Children with Influenza A Viral Pneumonia. ( 26642702 )
2015
27
Middle East respiratory syndrome (MERS): a new zoonotic viral pneumonia. ( 25089913 )
2014
28
Viral pneumonia in severe respiratory failure. ( 24602995 )
2014
29
Aging exacerbates damage and delays repair of alveolar epithelia following influenza viral pneumonia. ( 25265939 )
2014
30
Combination therapy with hepatocyte growth factor and oseltamivir confers enhanced protection against influenza viral pneumonia. ( 24894172 )
2014
31
Epidemiology, etiology, x-ray features, importance of co-infections and clinical features of viral pneumonia in developing countries. ( 24410617 )
2014
32
Predictors of viral pneumonia in patients with community-acquired pneumonia. ( 25531901 )
2014
33
Influenza and endemic viral pneumonia. ( 24094391 )
2013
34
Macrolide-based regimens in absence of bacterial co-infection in critically ill H1N1 patients with primary viral pneumonia. ( 23344833 )
2013
35
Gravity-dependent opacity in pure influenza viral pneumonia. ( 23370759 )
2013
36
Predictors of viral pneumonia: the need for viral testing in all patients hospitalized for nursing home-acquired pneumonia. ( 23441872 )
2013
37
Effect of the Haoqinqingdan decoction on damp-heat syndrome in rats with influenza viral pneumonia. ( 23790339 )
2013
38
H7N9 viral pneumonia: asymmetric and irregular changes on computed tomography. ( 24342341 )
2013
39
IgA level in plasma as a differential factor for influenza infection in severe viral pneumonia. ( 24380719 )
2013
40
A Patient who Survived Primary Seasonal Influenza Viral Pneumonia: Histologic Findings Obtained via Bronchoscopy. ( 24334588 )
2013
41
Are statins beneficial for viral pneumonia? ( 23633609 )
2013
42
Integrated clinical, pathologic, virologic, and transcriptomic analysis of H5N1 influenza virus-induced viral pneumonia in the rhesus macaque. ( 22491448 )
2012
43
Comparison of initial high resolution computed tomography features in viral pneumonia between metapneumovirus infection and severe acute respiratory syndrome. ( 21439753 )
2012
44
Radiological findings in 210 paediatric patients with viral pneumonia: a retrospective case study. ( 22514104 )
2012
45
Clinical significance of pleural effusion in the new influenza A (H1N1) viral pneumonia in children and adolescent. ( 22028096 )
2012
46
Alveolar epithelial cells orchestrate DC function in murine viral pneumonia. ( 22996662 )
2012
47
Type I interferon signaling regulates Ly6C(hi) monocytes and neutrophils during acute viral pneumonia in mice. ( 21383977 )
2011
48
Viral pneumonia. ( 21435708 )
2011
49
ChemR23 dampens lung inflammation and enhances anti-viral immunity in a mouse model of acute viral pneumonia. ( 22072972 )
2011
50
H1N1: viral pneumonia as a cause of acute respiratory distress syndrome. ( 21157318 )
2011

Variations for Viral Pneumonia

Expression for Viral Pneumonia

Search GEO for disease gene expression data for Viral Pneumonia.

Pathways for Viral Pneumonia

GO Terms for Viral Pneumonia

Biological processes related to Viral Pneumonia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.56 CR1 CRP IFITM3 TLR9
2 positive regulation of interleukin-6 production GO:0032755 9.37 IL6 TLR9
3 acute-phase response GO:0006953 9.32 CRP IL6
4 inflammatory response GO:0006954 9.26 CRP IL17A IL6 TLR9
5 positive regulation of chemokine production GO:0032722 9.16 IL6 TLR9
6 negative regulation of lipid storage GO:0010888 8.62 CRP IL6

Sources for Viral Pneumonia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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