MCID: VRS001
MIFTS: 38

Virus Associated Hemophagocytic Syndrome

Categories: Blood diseases, Immune diseases, Rare diseases

Aliases & Classifications for Virus Associated Hemophagocytic Syndrome

MalaCards integrated aliases for Virus Associated Hemophagocytic Syndrome:

Name: Virus Associated Hemophagocytic Syndrome 54

Classifications:



Summaries for Virus Associated Hemophagocytic Syndrome

NIH Rare Diseases : 54 Virus associated hemophagocytic syndromeis a very serious complication of a viral infection. Signs and symptoms of virus associated hemophagocytic syndrome, include high fever, liver problems, enlarged liver and spleen, coagulation factor abnormalities, decreased red or white blood cells and platelets (pancytopenia), and a build-up of histiocytes, a type of immune cell, in various tissues in the body resulting in the destruction of blood-producing cells (histiocytic proliferation with prominent hemophagocytosis). Diagnosis is based upon the signs and symptoms of the patient. The cause of the condition is not known. Treatment is challenging and approach will vary depending on the age and medical history of the patient. Complications of this syndrome can become life threatening. Related conditions (conditions with overlapping signs and symptoms), include histiocytic medullary reticulosis (HMR), familial hemophagocytic lymphohistiocytosis (FHL), and X-linked lymphoproliferative syndrome.

MalaCards based summary : Virus Associated Hemophagocytic Syndrome is related to hemophagocytic syndrome associated with an infection and histiocytosis. An important gene associated with Virus Associated Hemophagocytic Syndrome is IL2 (Interleukin 2), and among its related pathways/superpathways are IL-2 Pathway and Pathways in cancer. The drugs Miconazole and Lenograstim have been mentioned in the context of this disorder. Affiliated tissues include spleen, liver and t cells, and related phenotypes are hematopoietic system and immune system

Related Diseases for Virus Associated Hemophagocytic Syndrome

Diseases related to Virus Associated Hemophagocytic Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 124)
# Related Disease Score Top Affiliating Genes
1 hemophagocytic syndrome associated with an infection 11.8
2 histiocytosis 10.3
3 malignant histiocytosis 10.3
4 polymorphic reticulosis 10.3
5 influenza 10.2
6 interstitial myocarditis 10.2 MB PIK3C2A
7 myositis 10.2 MB PIK3C2A
8 creatine phosphokinase, elevated serum 10.2 MB PIK3C2A
9 posterior myocardial infarction 10.2 MB PIK3C2A
10 myositis fibrosa 10.2 MB PIK3C2A
11 gas gangrene 10.2 MB PIK3C2A
12 anuria 10.2 MB PIK3C2A
13 neuroleptic malignant syndrome 10.1 MB PIK3C2A
14 plexopathy 10.1 MB PIK3C2A
15 compartment syndrome 10.1 MB PIK3C2A
16 b-cell expansion with nfkb and t-cell anergy 10.1 IL2 IL2RB
17 autoimmune vasculitis 10.1 IL2 IL4
18 intermediate coronary syndrome 10.1 MB PIK3C2A
19 pfeiffer syndrome 10.1
20 jak3-deficient severe combined immunodeficiency 10.1 IL2 IL4
21 pseudohyperkalemia, familial, 2, due to red cell leak 10.1 MB PIK3C2A
22 atopic keratoconjunctivitis 10.1 IL2 IL4
23 keratoconjunctivitis 10.1 IL2 IL4
24 conjunctivitis 10.1 IL2 IL4
25 acute mountain sickness 10.1 MB PIK3C2A
26 angiostrongyliasis 10.1 IL2 IL4
27 gaucher disease, type ii 10.1 IL2 IL4
28 autoimmune gastritis 10.1 IL2 IL4
29 malignant hyperthermia 10.1 MB PIK3C2A
30 vulvovaginal candidiasis 10.1 IL2 IL4
31 myoglobinuria 10.1 MB PIK3C2A
32 coccidiosis 10.1 IL2 IL4
33 acute kidney failure 10.1 MB PIK3C2A
34 severe combined immunodeficiency, x-linked 10.1 IL2 IL4
35 vernal conjunctivitis 10.1 IL2 IL4
36 aphthous stomatitis 10.1 IL2 IL4
37 acute graft versus host disease 10.1 IL2 IL4
38 trichinosis 10.1 IL4 PIK3C2A
39 onchocerciasis 10.1 IL2 IL4
40 autoimmune uveitis 10.1 IL2 IL4
41 paracoccidioidomycosis 10.1 IL2 IL4
42 disseminated intravascular coagulation 10.1 MB PIK3C2A
43 muscle tissue disease 10.1 MB PIK3C2A
44 hepatitis 10.1
45 parasitic helminthiasis infectious disease 10.1 IL2 IL4
46 brucellosis 10.1 IL2 IL4
47 peripheral t-cell lymphoma 10.1 IL2 IL2RB
48 tonsillitis 10.1 IL2 IL4
49 extrinsic cardiomyopathy 10.1 IL4 PIK3C2A
50 parasitic protozoa infectious disease 10.1 IL2 IL4

Graphical network of the top 20 diseases related to Virus Associated Hemophagocytic Syndrome:



Diseases related to Virus Associated Hemophagocytic Syndrome

Symptoms & Phenotypes for Virus Associated Hemophagocytic Syndrome

MGI Mouse Phenotypes related to Virus Associated Hemophagocytic Syndrome:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.43 CD68 IL2 IL2RB IL4 MB PIK3C2A
2 immune system MP:0005387 9.02 CD68 IL2 IL2RB IL4 PIK3C2A

Drugs & Therapeutics for Virus Associated Hemophagocytic Syndrome

Drugs for Virus Associated Hemophagocytic Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 50)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Not Applicable 22916-47-8 4189
2
Lenograstim Approved, Investigational Not Applicable 135968-09-1
3
Etoposide Approved Not Applicable 33419-42-0 36462
4
Busulfan Approved, Investigational Not Applicable 55-98-1 2478
5
leucovorin Approved Not Applicable 58-05-9 143 6006
6
Methotrexate Approved Not Applicable 1959-05-2, 59-05-2 126941
7
Cyclophosphamide Approved, Investigational Not Applicable 50-18-0, 6055-19-2 2907
8
Methylprednisolone Approved, Vet_approved Not Applicable 83-43-2 6741
9
Prednisone Approved, Vet_approved Not Applicable 53-03-2 5865
10
Methylprednisolone hemisuccinate Approved Not Applicable 2921-57-5
11
Prednisolone phosphate Approved, Vet_approved Not Applicable 302-25-0
12
Prednisolone Approved, Vet_approved Not Applicable 50-24-8 5755
13
Folic Acid Approved, Nutraceutical, Vet_approved Not Applicable 59-30-3 6037
14
Prednisolone hemisuccinate Experimental Not Applicable 2920-86-7
15 Folate Not Applicable
16 Nucleic Acid Synthesis Inhibitors Not Applicable
17 Immunosuppressive Agents Not Applicable
18 Antimetabolites Not Applicable
19 Folic Acid Antagonists Not Applicable
20 Immunologic Factors Not Applicable
21 Antirheumatic Agents Not Applicable
22 Anti-Infective Agents Not Applicable
23 Antifungal Agents Not Applicable
24 Dermatologic Agents Not Applicable
25 Topoisomerase Inhibitors Not Applicable
26 Vitamin B Complex Not Applicable
27 Antilymphocyte Serum Not Applicable
28 Antineoplastic Agents, Alkylating Not Applicable
29 Calcineurin Inhibitors Not Applicable
30 Antineoplastic Agents, Phytogenic Not Applicable
31 Antimetabolites, Antineoplastic Not Applicable
32 Alkylating Agents Not Applicable
33 Cyclosporins Not Applicable
34 Etoposide phosphate Not Applicable
35 Vitamin B9 Not Applicable
36 Gastrointestinal Agents Not Applicable
37 Hormones Not Applicable
38 glucocorticoids Not Applicable
39 Hormone Antagonists Not Applicable
40 Autonomic Agents Not Applicable
41 Methylprednisolone Acetate Not Applicable
42 Complement System Proteins Not Applicable
43 Prednisolone acetate Not Applicable
44 Protective Agents Not Applicable
45 Peripheral Nervous System Agents Not Applicable
46 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable
47 Antineoplastic Agents, Hormonal Not Applicable
48 Antiemetics Not Applicable
49 Anti-Inflammatory Agents Not Applicable
50 Neuroprotective Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pilot Study of Unrelated Donor Hematopoietic Stem Cell Transplantation in Patients With Life Threatening Hemophagocytic Disorders Unknown status NCT00006056 Not Applicable anti-thymocyte globulin;busulfan;cyclophosphamide;cyclosporine;etoposide;filgrastim;methotrexate
2 Allogeneic Bone Marrow Transplantation in Patients With Primary Immunodeficiencies Terminated NCT00006054 Not Applicable anti-thymocyte globulin;busulfan;cyclophosphamide;cyclosporine;etoposide;methotrexate;methylprednisolone;prednisone

Search NIH Clinical Center for Virus Associated Hemophagocytic Syndrome

Genetic Tests for Virus Associated Hemophagocytic Syndrome

Anatomical Context for Virus Associated Hemophagocytic Syndrome

MalaCards organs/tissues related to Virus Associated Hemophagocytic Syndrome:

42
Spleen, Liver, T Cells, Bone Marrow, Skin, Kidney, Tonsil

Publications for Virus Associated Hemophagocytic Syndrome

Articles related to Virus Associated Hemophagocytic Syndrome:

(show top 50) (show all 92)
# Title Authors Year
1
Epstein-Barr virus-associated hemophagocytic syndrome in a patient with ulcerative colitis during treatment with azathioprine: A case report and review of literature. ( 30510942 )
2018
2
Epstein-Barr Virus Associated Hemophagocytic Syndrome after Scrub Typhus Infection. ( 27883370 )
2016
3
Fulminant Epstein-Barr virus-associated hemophagocytic syndrome in a renal transplant patient and review of the literature. ( 27496079 )
2016
4
Virus-associated hemophagocytic syndrome in renal transplant recipients: report of 2 cases from a single center. ( 25838952 )
2015
5
Analysis of prognostic risk factors in children with Epstein-Barr virus-associated hemophagocytic syndrome. ( 25941132 )
2015
6
BK virus-associated hemophagocytic syndrome in a renal transplant recipient. ( 24821160 )
2014
7
Cytokine nephropathy in a patient with fatal Epstein-Barr virus-associated hemophagocytic syndrome. ( 23991898 )
2013
8
A case of novel swine influenza A (H1N1) pneumonia complicated with virus-associated hemophagocytic syndrome. ( 22286408 )
2012
9
Repeated Epstein-Barr virus-associated hemophagocytic syndrome in a lupus nephritis patient. ( 22185972 )
2012
10
Ocular findings in a patient with virus-associated hemophagocytic syndrome. ( 22486263 )
2012
11
Virus-associated hemophagocytic syndrome caused by pandemic swine-origin influenza A (H1N1) in a patient after unrelated bone marrow transplantation. ( 21628863 )
2011
12
Virus-associated hemophagocytic syndrome as a major contributor to death in patients with 2009 influenza A (H1N1) infection. ( 21366922 )
2011
13
Dengue virus associated hemophagocytic syndrome in children: a case report. ( 20853575 )
2010
14
Novel swine-origin influenza A (H1N1) virus-associated hemophagocytic syndrome--a first case report. ( 20348529 )
2010
15
Kaposi sarcoma herpes virus-associated hemophagocytic syndrome complicated by multicentric castleman disease and kaposi sarcoma in a HIV-negative immunocompetent patient: an autopsy case. ( 19795003 )
2009
16
Epstein-Barr virus-induced infectious mononucleosis after two separate episodes of virus-associated hemophagocytic syndrome. ( 19571453 )
2009
17
Virus-Associated Hemophagocytic Syndrome related to acute CMV and HBV sexual co-infection: a case report. ( 19640781 )
2009
18
Epstein-Barr virus-associated hemophagocytic syndrome mimicking severe sepsis. ( 19561991 )
2008
19
Emergence of anti-red blood cell antibodies triggers red cell phagocytosis by activated macrophages in a rabbit model of Epstein-Barr virus-associated hemophagocytic syndrome. ( 17456768 )
2007
20
Severe Epstein-Barr virus-associated hemophagocytic syndrome in six adult patients. ( 17703994 )
2007
21
Cytokine profile in fatal human immunodeficiency virus tuberculosis Epstein-Barr virus associated hemophagocytic syndrome. ( 17893313 )
2007
22
Virus associated hemophagocytic syndrome accompanied by acute respiratory failure caused by influenza A (H3N2). ( 17106167 )
2006
23
Late-onset fatal Epstein-Barr virus-associated hemophagocytic syndrome following cord blood cell transplantation for adult acute lymphoblastic leukemia. ( 17189228 )
2006
24
Mumps virus-associated hemophagocytic syndrome. ( 15759337 )
2005
25
Epstein-Barr virus-associated hemophagocytic syndrome in a patient with lupus nephritis. ( 15625619 )
2005
26
Cyclosporin neurotoxicity with Epstein-Barr virus-associated hemophagocytic syndrome. ( 15753052 )
2005
27
Dengue virus-associated hemophagocytic syndrome and dyserythropoiesis: a case report. ( 15754587 )
2005
28
Virus-associated hemophagocytic syndrome in an international traveler as a differential diagnosis of SARS. ( 15897649 )
2005
29
Epstein-Barr virus-associated hemophagocytic syndrome as first presentation of Fanconi anemia. ( 15926162 )
2005
30
Virus-associated hemophagocytic syndrome and hemorrhagic jejunal ulcer caused by cytomegalovirus infection in a non-compromised host; a case report of unusual entity. ( 15086189 )
2004
31
Virological and immunological characteristics of a 19-year-old Japanese female with fatal outcome with Epstein-Barr virus-associated hemophagocytic syndrome. ( 15465418 )
2004
32
Latency pattern of Epstein-Barr virus and methylation status in Epstein-Barr virus-associated hemophagocytic syndrome. ( 12767005 )
2003
33
Unusual clinical manifestation of virus-associated hemophagocytic syndrome. ( 14708643 )
2003
34
Viral load in Epstein-Barr virus-associated hemophagocytic syndrome. ( 12363023 )
2002
35
Sequential quantification of Epstein-Barr virus DNA in a case of Epstein-Barr virus-associated hemophagocytic syndrome. ( 12416743 )
2002
36
Virus-associated hemophagocytic syndrome due to rubella virus and varicella-zoster virus dual infection in patient with adult idiopathic thrombocytopenic purpura. ( 11475151 )
2001
37
Epstein-Barr virus-associated hemophagocytic syndrome masquerading as lymphoma: a case report. ( 11456362 )
2001
38
No mutations of SAP/SH2D1A/DSHP and perforin genes in patients with Epstein-Barr virus-associated hemophagocytic syndrome in Japan. ( 11536244 )
2001
39
CNS involvement of virus-associated hemophagocytic syndrome: MR imaging appearance. ( 10954276 )
2000
40
Fatal virus-associated hemophagocytic syndrome associated with coexistent chronic active hepatitis B and acute hepatitis C virus infection. ( 10367794 )
1999
41
Clinicopathological findings of virus-associated hemophagocytic syndrome in bone marrow: association with Epstein-Barr virus and apoptosis. ( 10469396 )
1999
42
Liver and spleen MRI findings in virus-associated hemophagocytic syndrome in a patient with acute lymphocytic leukemia. ( 9880630 )
1998
43
Severe chronic active Epstein-Barr virus infection accompanied by virus-associated hemophagocytic syndrome, cerebellar ataxia and encephalitis. ( 9766697 )
1998
44
Virus-associated hemophagocytic syndrome after hepatic resection: a case report. ( 9496516 )
1998
45
Therapy-related AML after successful chemotherapy with low dose etoposide for virus-associated hemophagocytic syndrome. ( 9846019 )
1998
46
Epstein-Barr virus--Associated hemophagocytic syndrome. A cause of fever of unknown origin in human immunodeficiency virus infection. ( 9278614 )
1997
47
Epstein Barr virus associated hemophagocytic syndrome--a case report. ( 9364304 )
1997
48
Epstein-Barr virus induced virus-associated hemophagocytic syndrome and monoclonal TCR-beta rearrangement: a case report. ( 9378473 )
1997
49
Host defensive, immunological, and microbiological observations of an early-onset periodontitis patient with virus-associated hemophagocytic syndrome. ( 9444599 )
1997
50
The use of cyclosporin-A in the treatment of virus-associated hemophagocytic syndrome in adults. ( 9498706 )
1997

Variations for Virus Associated Hemophagocytic Syndrome

Expression for Virus Associated Hemophagocytic Syndrome

Search GEO for disease gene expression data for Virus Associated Hemophagocytic Syndrome.

Pathways for Virus Associated Hemophagocytic Syndrome

Pathways related to Virus Associated Hemophagocytic Syndrome according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.81 IL2 IL2RB IL4 PIK3C2A
2 12.49 IL2 IL2RB IL4
3
Show member pathways
12.42 IL2 IL2RB IL4
4
Show member pathways
12.25 IL2 IL2RB IL4
5 12.2 IL2 IL2RB IL4
6
Show member pathways
12.04 IL2 IL2RB IL4
7
Show member pathways
12.01 IL2 IL2RB PIK3C2A
8
Show member pathways
11.74 IL2 IL2RB IL4
9
Show member pathways
11.63 IL2 IL2RB IL4
10 11.5 IL2 IL4
11
Show member pathways
11.46 IL2 IL4
12 11.45 IL2 IL2RB IL4
13 11.35 CD68 IL2 IL4
14
Show member pathways
11.34 IL2 IL2RB
15
Show member pathways
11.26 IL2 IL2RB IL4
16 10.99 IL2 IL2RB IL4
17 10.99 CD68 IL2 IL2RB IL4
18 10.94 IL2 IL4
19
Show member pathways
10.92 IL2 IL2RB
20 10.85 IL2 IL4
21 10.65 IL2 IL2RB IL4

GO Terms for Virus Associated Hemophagocytic Syndrome

Biological processes related to Virus Associated Hemophagocytic Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.61 IL2 IL2RB IL4
2 cytokine-mediated signaling pathway GO:0019221 9.43 IL2 IL2RB IL4
3 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.4 IL2 IL4
4 positive regulation of T cell proliferation GO:0042102 9.37 IL2 IL4
5 positive regulation of B cell proliferation GO:0030890 9.32 IL2 IL4
6 positive regulation of T cell differentiation GO:0045582 9.16 IL2 IL4
7 interleukin-2-mediated signaling pathway GO:0038110 8.96 IL2 IL2RB
8 positive regulation of isotype switching to IgG isotypes GO:0048304 8.62 IL2 IL4

Sources for Virus Associated Hemophagocytic Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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