MCID: VRS001
MIFTS: 38

Virus Associated Hemophagocytic Syndrome

Categories: Blood diseases, Immune diseases, Rare diseases

Aliases & Classifications for Virus Associated Hemophagocytic Syndrome

MalaCards integrated aliases for Virus Associated Hemophagocytic Syndrome:

Name: Virus Associated Hemophagocytic Syndrome 53

Classifications:



Summaries for Virus Associated Hemophagocytic Syndrome

NIH Rare Diseases : 53 Virus associated hemophagocytic syndromeis a very serious complication of a viral infection. Signs and symptoms of virus associated hemophagocytic syndrome, include high fever, liver problems, enlarged liver and spleen, coagulation factor abnormalities, decreased red or white blood cells and platelets (pancytopenia), and a build-up of histiocytes, a type of immune cell, in various tissues in the body resulting in the destruction of blood-producing cells (histiocytic proliferation with prominent hemophagocytosis). Diagnosis is based upon the signs and symptoms of the patient. The cause of the condition is not known. Treatment is challenging and approach will vary depending on the age and medical history of the patient. Complications of this syndrome can become life threatening. Related conditions (conditions with overlapping signs and symptoms), include histiocytic medullary reticulosis (HMR), familial hemophagocytic lymphohistiocytosis (FHL), and X-linked lymphoproliferative syndrome.

MalaCards based summary : Virus Associated Hemophagocytic Syndrome is related to hemophagocytic syndrome associated with an infection and histiocytosis. An important gene associated with Virus Associated Hemophagocytic Syndrome is IL2 (Interleukin 2), and among its related pathways/superpathways are IL-2 Pathway and Pathways in cancer. The drugs leucovorin and Methotrexate have been mentioned in the context of this disorder. Affiliated tissues include liver, spleen and bone, and related phenotypes are hematopoietic system and immune system

Related Diseases for Virus Associated Hemophagocytic Syndrome

Diseases related to Virus Associated Hemophagocytic Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 123)
# Related Disease Score Top Affiliating Genes
1 hemophagocytic syndrome associated with an infection 11.8
2 histiocytosis 10.3
3 malignant histiocytosis 10.3
4 viral infectious disease 10.3
5 influenza 10.2
6 autoimmune vasculitis 10.2 IL2 IL4
7 jak3-deficient severe combined immunodeficiency 10.2 IL2 IL4
8 atopic keratoconjunctivitis 10.2 IL2 IL4
9 keratoconjunctivitis 10.1 IL2 IL4
10 conjunctivitis 10.1 IL2 IL4
11 gaucher disease, type ii 10.1 IL2 IL4
12 angiostrongyliasis 10.1 IL2 IL4
13 autoimmune gastritis 10.1 IL2 IL4
14 vulvovaginal candidiasis 10.1 IL2 IL4
15 coccidiosis 10.1 IL2 IL4
16 severe combined immunodeficiency, x-linked 10.1 IL2 IL4
17 vernal conjunctivitis 10.1 IL2 IL4
18 aphthous stomatitis 10.1 IL2 IL4
19 acute graft versus host disease 10.1 IL2 IL4
20 onchocerciasis 10.1 IL2 IL4
21 autoimmune uveitis 10.1 IL2 IL4
22 paracoccidioidomycosis 10.1 IL2 IL4
23 parasitic helminthiasis infectious disease 10.1 IL2 IL4
24 brucellosis 10.1 IL2 IL4
25 tonsillitis 10.1 IL2 IL4
26 parasitic protozoa infectious disease 10.1 IL2 IL4
27 leprosy 3 10.1 IL2 IL4
28 agammaglobulinemia, x-linked 10.1 IL2 IL4
29 autoimmune disease of musculoskeletal system 10.1 IL2 IL4
30 autoimmune disease of central nervous system 10.1 IL2 IL4
31 primary bacterial infectious disease 10.1 IL2 IL4
32 b-cell expansion with nfkb and t-cell anergy 10.1 IL2 IL2RB
33 autoimmune disease of the nervous system 10.1 IL2 IL4
34 leukocyte disease 10.1 IL2 IL4
35 visceral leishmaniasis 10.1 IL2 IL4
36 bone inflammation disease 10.1 IL2 IL4
37 toxic shock syndrome 10.1 IL2 IL4
38 sezary's disease 10.1 IL2 IL4
39 respiratory allergy 10.1 IL2RB IL4
40 schistosomiasis 10.1 IL2 IL4
41 hepatitis 10.1
42 trichinosis 10.1 IL4 PIK3C2A
43 trypanosomiasis 10.1 IL2 IL4
44 interstitial myocarditis 10.1 MB PIK3C2A
45 immune system disease 10.1 IL2 IL4
46 peripheral t-cell lymphoma 10.0 IL2 IL2RB
47 myositis 10.0 MB PIK3C2A
48 extrinsic cardiomyopathy 10.0 IL4 PIK3C2A
49 creatine phosphokinase, elevated serum 10.0 MB PIK3C2A
50 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 10.0 IL2 IL4

Graphical network of the top 20 diseases related to Virus Associated Hemophagocytic Syndrome:



Diseases related to Virus Associated Hemophagocytic Syndrome

Symptoms & Phenotypes for Virus Associated Hemophagocytic Syndrome

MGI Mouse Phenotypes related to Virus Associated Hemophagocytic Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.43 CD68 IL2 IL2RB IL4 MB PIK3C2A
2 immune system MP:0005387 9.02 CD68 IL2 IL2RB IL4 PIK3C2A

Drugs & Therapeutics for Virus Associated Hemophagocytic Syndrome

Drugs for Virus Associated Hemophagocytic Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 50)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
leucovorin Approved Not Applicable 58-05-9 6006 143
2
Methotrexate Approved Not Applicable 59-05-2, 1959-05-2 126941
3
Busulfan Approved, Investigational Not Applicable 55-98-1 2478
4
Cyclophosphamide Approved, Investigational Not Applicable 6055-19-2, 50-18-0 2907
5
Lenograstim Approved, Investigational Not Applicable 135968-09-1
6
Etoposide Approved Not Applicable 33419-42-0 36462
7
Miconazole Approved, Investigational, Vet_approved Not Applicable 22916-47-8 4189
8
Methylprednisolone Approved, Vet_approved Not Applicable 83-43-2 6741
9
Prednisolone Approved, Vet_approved Not Applicable 50-24-8 5755
10
Prednisone Approved, Vet_approved Not Applicable 53-03-2 5865
11
Methylprednisolone hemisuccinate Approved Not Applicable 2921-57-5
12
Prednisolone phosphate Approved, Vet_approved Not Applicable 302-25-0
13
Folic Acid Approved, Nutraceutical, Vet_approved Not Applicable 59-30-3 6037
14
Prednisolone hemisuccinate Experimental Not Applicable 2920-86-7
15 Immunosuppressive Agents Not Applicable
16 Antirheumatic Agents Not Applicable
17 Antilymphocyte Serum Not Applicable
18 Immunologic Factors Not Applicable
19 Antineoplastic Agents, Phytogenic Not Applicable
20 Calcineurin Inhibitors Not Applicable
21 Alkylating Agents Not Applicable
22 Antifungal Agents Not Applicable
23 Vitamin B Complex Not Applicable
24 Dermatologic Agents Not Applicable
25 Etoposide phosphate Not Applicable
26 Topoisomerase Inhibitors Not Applicable
27 Folate Not Applicable
28 Antineoplastic Agents, Alkylating Not Applicable
29 Folic Acid Antagonists Not Applicable
30 Anti-Infective Agents Not Applicable
31 Cyclosporins Not Applicable
32 Antimetabolites, Antineoplastic Not Applicable
33 Nucleic Acid Synthesis Inhibitors Not Applicable
34 Vitamin B9 Not Applicable
35 Antimetabolites Not Applicable
36 Neuroprotective Agents Not Applicable
37 Autonomic Agents Not Applicable
38 Protective Agents Not Applicable
39 Prednisolone acetate Not Applicable
40 Antiemetics Not Applicable
41 Peripheral Nervous System Agents Not Applicable
42 Gastrointestinal Agents Not Applicable
43 Hormone Antagonists Not Applicable
44 glucocorticoids Not Applicable
45 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable
46 Complement System Proteins Not Applicable
47 Methylprednisolone acetate Not Applicable
48 Anti-Inflammatory Agents Not Applicable
49 Antineoplastic Agents, Hormonal Not Applicable
50 Hormones Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pilot Study of Unrelated Donor Hematopoietic Stem Cell Transplantation in Patients With Life Threatening Hemophagocytic Disorders Unknown status NCT00006056 Not Applicable anti-thymocyte globulin;busulfan;cyclophosphamide;cyclosporine;etoposide;filgrastim;methotrexate
2 Allogeneic Bone Marrow Transplantation in Patients With Primary Immunodeficiencies Terminated NCT00006054 Not Applicable anti-thymocyte globulin;busulfan;cyclophosphamide;cyclosporine;etoposide;methotrexate;methylprednisolone;prednisone

Search NIH Clinical Center for Virus Associated Hemophagocytic Syndrome

Genetic Tests for Virus Associated Hemophagocytic Syndrome

Anatomical Context for Virus Associated Hemophagocytic Syndrome

MalaCards organs/tissues related to Virus Associated Hemophagocytic Syndrome:

41
Liver, Spleen, Bone, Bone Marrow, T Cells, Kidney, Thyroid

Publications for Virus Associated Hemophagocytic Syndrome

Articles related to Virus Associated Hemophagocytic Syndrome:

(show top 50) (show all 93)
# Title Authors Year
1
Epstein-Barr virus-associated hemophagocytic syndrome in a patient with ulcerative colitis during treatment with azathioprine: A case report and review of literature. ( 30510942 )
2018
2
Fulminant Epstein-Barr virus-associated hemophagocytic syndrome in a renal transplant patient and review of the literature. ( 27496079 )
2016
3
Epstein-Barr Virus Associated Hemophagocytic Syndrome after Scrub Typhus Infection. ( 27883370 )
2016
4
Analysis of prognostic risk factors in children with Epstein-Barr virus-associated hemophagocytic syndrome. ( 25941132 )
2015
5
P488. Virus associated hemophagocytic syndrome: rare but serious complication of azathioprine treatment in patients with CrohnA' s disease. ( 25717983 )
2015
6
Virus-associated hemophagocytic syndrome in renal transplant recipients: report of 2 cases from a single center. ( 25838952 )
2015
7
BK virus-associated hemophagocytic syndrome in a renal transplant recipient. ( 24821160 )
2014
8
Cytokine nephropathy in a patient with fatal Epstein-Barr virus-associated hemophagocytic syndrome. ( 23991898 )
2013
9
Ocular findings in a patient with virus-associated hemophagocytic syndrome. ( 22486263 )
2012
10
A case of novel swine influenza A (H1N1) pneumonia complicated with virus-associated hemophagocytic syndrome. ( 22286408 )
2012
11
Repeated Epstein-Barr virus-associated hemophagocytic syndrome in a lupus nephritis patient. ( 22185972 )
2012
12
Virus-associated hemophagocytic syndrome as a major contributor to death in patients with 2009 influenza A (H1N1) infection. ( 21366922 )
2011
13
Virus-associated hemophagocytic syndrome caused by pandemic swine-origin influenza A (H1N1) in a patient after unrelated bone marrow transplantation. ( 21628863 )
2011
14
Dengue virus associated hemophagocytic syndrome in children: a case report. ( 20853575 )
2010
15
Novel swine-origin influenza A (H1N1) virus-associated hemophagocytic syndrome--a first case report. ( 20348529 )
2010
16
Epstein-Barr virus-induced infectious mononucleosis after two separate episodes of virus-associated hemophagocytic syndrome. ( 19571453 )
2009
17
Virus-Associated Hemophagocytic Syndrome related to acute CMV and HBV sexual co-infection: a case report. ( 19640781 )
2009
18
Kaposi sarcoma herpes virus-associated hemophagocytic syndrome complicated by multicentric castleman disease and kaposi sarcoma in a HIV-negative immunocompetent patient: an autopsy case. ( 19795003 )
2009
19
Epstein-Barr virus-associated hemophagocytic syndrome mimicking severe sepsis. ( 19561991 )
2008
20
Cytokine profile in fatal human immunodeficiency virus tuberculosis Epstein-Barr virus associated hemophagocytic syndrome. ( 17893313 )
2007
21
Emergence of anti-red blood cell antibodies triggers red cell phagocytosis by activated macrophages in a rabbit model of Epstein-Barr virus-associated hemophagocytic syndrome. ( 17456768 )
2007
22
Severe Epstein-Barr virus-associated hemophagocytic syndrome in six adult patients. ( 17703994 )
2007
23
Late-onset fatal Epstein-Barr virus-associated hemophagocytic syndrome following cord blood cell transplantation for adult acute lymphoblastic leukemia. ( 17189228 )
2006
24
Virus associated hemophagocytic syndrome accompanied by acute respiratory failure caused by influenza A (H3N2). ( 17106167 )
2006
25
Mumps virus-associated hemophagocytic syndrome. ( 15759337 )
2005
26
Cyclosporin neurotoxicity with Epstein-Barr virus-associated hemophagocytic syndrome. ( 15753052 )
2005
27
Dengue virus-associated hemophagocytic syndrome and dyserythropoiesis: a case report. ( 15754587 )
2005
28
Epstein-Barr virus-associated hemophagocytic syndrome as first presentation of Fanconi anemia. ( 15926162 )
2005
29
Virus-associated hemophagocytic syndrome in an international traveler as a differential diagnosis of SARS. ( 15897649 )
2005
30
Epstein-Barr virus-associated hemophagocytic syndrome in a patient with lupus nephritis. ( 15625619 )
2005
31
Virus-associated hemophagocytic syndrome and hemorrhagic jejunal ulcer caused by cytomegalovirus infection in a non-compromised host; a case report of unusual entity. ( 15086189 )
2004
32
Virological and immunological characteristics of a 19-year-old Japanese female with fatal outcome with Epstein-Barr virus-associated hemophagocytic syndrome. ( 15465418 )
2004
33
Unusual clinical manifestation of virus-associated hemophagocytic syndrome. ( 14708643 )
2003
34
Latency pattern of Epstein-Barr virus and methylation status in Epstein-Barr virus-associated hemophagocytic syndrome. ( 12767005 )
2003
35
Sequential quantification of Epstein-Barr virus DNA in a case of Epstein-Barr virus-associated hemophagocytic syndrome. ( 12416743 )
2002
36
Viral load in Epstein-Barr virus-associated hemophagocytic syndrome. ( 12363023 )
2002
37
Epstein-Barr virus-associated hemophagocytic syndrome masquerading as lymphoma: a case report. ( 11456362 )
2001
38
No mutations of SAP/SH2D1A/DSHP and perforin genes in patients with Epstein-Barr virus-associated hemophagocytic syndrome in Japan. ( 11536244 )
2001
39
Virus-associated hemophagocytic syndrome due to rubella virus and varicella-zoster virus dual infection in patient with adult idiopathic thrombocytopenic purpura. ( 11475151 )
2001
40
CNS involvement of virus-associated hemophagocytic syndrome: MR imaging appearance. ( 10954276 )
2000
41
Fatal virus-associated hemophagocytic syndrome associated with coexistent chronic active hepatitis B and acute hepatitis C virus infection. ( 10367794 )
1999
42
Clinicopathological findings of virus-associated hemophagocytic syndrome in bone marrow: association with Epstein-Barr virus and apoptosis. ( 10469396 )
1999
43
Therapy-related AML after successful chemotherapy with low dose etoposide for virus-associated hemophagocytic syndrome. ( 9846019 )
1998
44
Liver and spleen MRI findings in virus-associated hemophagocytic syndrome in a patient with acute lymphocytic leukemia. ( 9880630 )
1998
45
Virus-associated hemophagocytic syndrome after hepatic resection: a case report. ( 9496516 )
1998
46
Severe chronic active Epstein-Barr virus infection accompanied by virus-associated hemophagocytic syndrome, cerebellar ataxia and encephalitis. ( 9766697 )
1998
47
The use of cyclosporin-A in the treatment of virus-associated hemophagocytic syndrome in adults. ( 9498706 )
1997
48
Epstein-Barr virus--Associated hemophagocytic syndrome. A cause of fever of unknown origin in human immunodeficiency virus infection. ( 9278614 )
1997
49
Epstein Barr virus associated hemophagocytic syndrome--a case report. ( 9364304 )
1997
50
Host defensive, immunological, and microbiological observations of an early-onset periodontitis patient with virus-associated hemophagocytic syndrome. ( 9444599 )
1997

Variations for Virus Associated Hemophagocytic Syndrome

Expression for Virus Associated Hemophagocytic Syndrome

Search GEO for disease gene expression data for Virus Associated Hemophagocytic Syndrome.

Pathways for Virus Associated Hemophagocytic Syndrome

Pathways related to Virus Associated Hemophagocytic Syndrome according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.81 IL2 IL2RB IL4 PIK3C2A
2 12.5 IL2 IL2RB IL4
3
Show member pathways
12.44 IL2 IL2RB IL4
4
Show member pathways
12.42 IL2 IL2RB IL4
5
Show member pathways
12.25 IL2 IL2RB IL4
6 12.2 IL2 IL2RB IL4
7
Show member pathways
12.04 IL2 IL2RB IL4
8
Show member pathways
12.01 IL2 IL2RB PIK3C2A
9
Show member pathways
11.74 IL2 IL2RB IL4
10
Show member pathways
11.63 IL2 IL2RB IL4
11 11.51 IL2 IL4
12
Show member pathways
11.46 IL2 IL4
13 11.45 IL2 IL2RB IL4
14 11.35 CD68 IL2 IL4
15
Show member pathways
11.34 IL2 IL2RB
16
Show member pathways
11.26 IL2 IL2RB IL4
17 10.99 IL2 IL2RB IL4
18 10.99 CD68 IL2 IL2RB IL4
19 10.94 IL2 IL4
20
Show member pathways
10.93 IL2 IL2RB
21 10.85 IL2 IL4
22 10.65 IL2 IL2RB IL4

GO Terms for Virus Associated Hemophagocytic Syndrome

Biological processes related to Virus Associated Hemophagocytic Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.61 IL2 IL2RB IL4
2 cytokine-mediated signaling pathway GO:0019221 9.43 IL2 IL2RB IL4
3 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.4 IL2 IL4
4 positive regulation of T cell proliferation GO:0042102 9.37 IL2 IL4
5 positive regulation of B cell proliferation GO:0030890 9.32 IL2 IL4
6 positive regulation of T cell differentiation GO:0045582 9.16 IL2 IL4
7 interleukin-2-mediated signaling pathway GO:0038110 8.96 IL2 IL2RB
8 positive regulation of isotype switching to IgG isotypes GO:0048304 8.62 IL2 IL4

Sources for Virus Associated Hemophagocytic Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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