Visual Cortex Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Visual Cortex Disease

MalaCards integrated aliases for Visual Cortex Disease:

Name: Visual Cortex Disease ¹² ¹⁵

Visual Cortex Dysfunction ¹²

Visual Cortex Disorder ⁷¹

Classifications:

MalaCards categories:
Anatomical: Eye diseases Neuronal diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Diseases of the eye and adnexa

Disorders of optic nerve and visual pathways

Other disorders of optic [2nd] nerve and visual pathways

Disorders of visual cortex

External Ids:

Disease Ontology ¹² DOID:5691

ICD9CM ³⁴ 377.7

NCIt ⁴⁹ C35275

SNOMED-CT ⁶⁷ 128329001

ICD10 ³² H47.6

UMLS ⁷¹ C0234398

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Summaries for Visual Cortex Disease

MalaCards based summary : Visual Cortex Disease, also known as visual cortex dysfunction, is related to pearson marrow-pancreas syndrome and auditory agnosia. An important gene associated with Visual Cortex Disease is SLC26A5 (Solute Carrier Family 26 Member 5), and among its related pathways/superpathways are Mitochondrial protein import and NCAM1 interactions. Affiliated tissues include cortex, eye and brain.

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Related Diseases for Visual Cortex Disease

Diseases related to Visual Cortex Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)

#	Related Disease	Score	Top Affiliating Genes
1	pearson marrow-pancreas syndrome	10.1	POLG MT-TL1
2	auditory agnosia	10.1	PRNP MT-TL1
3	3-methylglutaconic aciduria	10.0	TIMM8A POLG MT-TL1
4	hypertensive encephalopathy	10.0	SLC26A5 CABIN1
5	sengers syndrome	9.9	TIMM29 TIMM10B
6	leber optic atrophy	9.8	TIMM8A POLG MT-TL1
7	mohr-tranebjaerg syndrome	9.8	TIMM8A TIMM29 TIMM13 TIMM10B TIMM10
8	mitochondrial metabolism disease	9.3	TIMM8A TIMM29 TIMM13 TIMM10B TIMM10 POLG
9	dystonia	9.3	TIMM8A TIMM13 TIMM10B TIMM10 RNASEH2C POLG
10	cortical blindness	9.1	TIMM8A TIMM29 TIMM13 TIMM10 SLC26A5 SAMD15
11	visual pathway disease	6.1	TMED8 TIMM8A TIMM29 TIMM13 TIMM10B TIMM10

Graphical network of the top 20 diseases related to Visual Cortex Disease:

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Symptoms & Phenotypes for Visual Cortex Disease

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Drugs & Therapeutics for Visual Cortex Disease

Search Clinical Trials , NIH Clinical Center for Visual Cortex Disease

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Genetic Tests for Visual Cortex Disease

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Anatomical Context for Visual Cortex Disease

MalaCards organs/tissues related to Visual Cortex Disease:

⁴⁰

Cortex, Eye, Brain

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Publications for Visual Cortex Disease

Articles related to Visual Cortex Disease:

#	Title	Authors	PMID	Year
1	Frequency-Specific Changes of Resting Brain Activity in Parkinson's Disease: A Machine Learning Approach. ⁶¹	Tian ZY...Shao J	32059985	2020

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Genes for Visual Cortex Disease

Genes related to Visual Cortex Disease (0 elite genes):

(show all 22)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	SLC26A5	Solute Carrier Family 26 Member 5	Protein Coding	6.57	DISEASES inferred ¹⁵
2	C14orf178	Chromosome 14 Open Reading Frame 178	RNA Gene	6.27	DISEASES inferred ¹⁵
3	NOXRED1	NADP Dependent Oxidoreductase Domain Containing 1	Protein Coding	6.22	DISEASES inferred ¹⁵
4	POLG	DNA Polymerase Gamma, Catalytic Subunit	Protein Coding	6.21	DISEASES inferred ¹⁵
5	TIMM8A	Translocase Of Inner Mitochondrial Membrane 8A	Protein Coding	6.2	DISEASES inferred ¹⁵
6	SAMD15	Sterile Alpha Motif Domain Containing 15	Protein Coding	6.14	DISEASES inferred ¹⁵
7	TIMM29	Translocase Of Inner Mitochondrial Membrane 29	Protein Coding	6.03	DISEASES inferred ¹⁵
8	TIMM13	Translocase Of Inner Mitochondrial Membrane 13	Protein Coding	5.98	DISEASES inferred ¹⁵
9	TIMM10	Translocase Of Inner Mitochondrial Membrane 10	Protein Coding	5.96	DISEASES inferred ¹⁵
10	HNMT	Histamine N-Methyltransferase	Protein Coding	5.94	DISEASES inferred ¹⁵
11	TIMM10B	Translocase Of Inner Mitochondrial Membrane 10B	Protein Coding	5.92	DISEASES inferred ¹⁵
12	INKA1	Inka Box Actin Regulator 1	Protein Coding	5.84	DISEASES inferred ¹⁵
13	DOCK7	Dedicator Of Cytokinesis 7	Protein Coding	5.84	DISEASES inferred ¹⁵
14	PRNP	Prion Protein	Protein Coding	5.8	DISEASES inferred ¹⁵
15	MT-TL1	Mitochondrially Encoded TRNA-Leu (UUA/G) 1	RNA Gene	5.76	DISEASES inferred ¹⁵
16	TMED8	Transmembrane P24 Trafficking Protein Family Member 8	Protein Coding	5.67	DISEASES inferred ¹⁵
17	RNASEH2C	Ribonuclease H2 Subunit C	Protein Coding	5.66	DISEASES inferred ¹⁵
18	ST8SIA2	ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase 2	Protein Coding	5.63	DISEASES inferred ¹⁵
19	CABIN1	Calcineurin Binding Protein 1	Protein Coding	5.6	DISEASES inferred ¹⁵
20	INKA2	Inka Box Actin Regulator 2	Protein Coding	5.6	DISEASES inferred ¹⁵
21	RNASEH2B	Ribonuclease H2 Subunit B	Protein Coding	5.54	DISEASES inferred ¹⁵
22	POLG2	DNA Polymerase Gamma 2, Accessory Subunit	Protein Coding	5.53	DISEASES inferred ¹⁵

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Variations for Visual Cortex Disease

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Expression for Visual Cortex Disease

Search GEO for disease gene expression data for Visual Cortex Disease.

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Pathways for Visual Cortex Disease

Pathways related to Visual Cortex Disease according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Mitochondrial protein import ⁶⁵	10.72	TIMM8A TIMM13 TIMM10B TIMM10
2	NCAM1 interactions ⁶⁵	10.52	ST8SIA2 PRNP

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GO Terms for Visual Cortex Disease

Cellular components related to Visual Cortex Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	mitochondrial inner membrane	GO:0005743	9.65	TIMM8A TIMM29 TIMM13 TIMM10B TIMM10
2	TIM22 mitochondrial import inner membrane insertion complex	GO:0042721	9.16	TIMM29 TIMM10B
3	mitochondrial intermembrane space protein transporter complex	GO:0042719	9.13	TIMM13 TIMM10B TIMM10
4	mitochondrial intermembrane space	GO:0005758	9.02	TIMM8A TIMM29 TIMM13 TIMM10B TIMM10

Biological processes related to Visual Cortex Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein transport	GO:0015031	9.65	TIMM8A TIMM29 TIMM13 TIMM10B TIMM10
2	sensory perception of sound	GO:0007605	9.54	TIMM13 TIMM10 SLC26A5
3	protein targeting to mitochondrion	GO:0006626	9.33	TIMM13 TIMM10B TIMM10
4	negative regulation of protein serine/threonine kinase activity	GO:0071901	9.32	INKA2 INKA1
5	chaperone-mediated protein transport	GO:0072321	9.13	TIMM8A TIMM13 TIMM10
6	protein import into mitochondrial inner membrane	GO:0045039	8.8	TIMM29 TIMM13 TIMM10

Molecular functions related to Visual Cortex Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein serine/threonine kinase inhibitor activity	GO:0030291	8.62	INKA2 INKA1

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Sources for Visual Cortex Disease

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia