MCID: VSL004
MIFTS: 23

Visual Cortex Disease

Categories: Eye diseases

Aliases & Classifications for Visual Cortex Disease

MalaCards integrated aliases for Visual Cortex Disease:

Name: Visual Cortex Disease 12 15
Visual Cortex Dysfunction 12
Visual Cortex Disorder 74

Classifications:



External Ids:

Disease Ontology 12 DOID:5691
ICD9CM 36 377.7
NCIt 51 C35275
SNOMED-CT 69 86492004
ICD10 34 H47.6
UMLS 74 C0234398

Summaries for Visual Cortex Disease

MalaCards based summary : Visual Cortex Disease, also known as visual cortex dysfunction, is related to ceroid lipofuscinosis, neuronal, 8, northern epilepsy variant and ceroid lipofuscinosis, neuronal, 7. An important gene associated with Visual Cortex Disease is CLN8 (CLN8 Transmembrane ER And ERGIC Protein). The drugs Magnesium Sulfate and Calcium have been mentioned in the context of this disorder. Affiliated tissues include cortex and eye, and related phenotypes are pigmentation and vision/eye

Related Diseases for Visual Cortex Disease

Graphical network of the top 20 diseases related to Visual Cortex Disease:



Diseases related to Visual Cortex Disease

Symptoms & Phenotypes for Visual Cortex Disease

MGI Mouse Phenotypes related to Visual Cortex Disease:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 pigmentation MP:0001186 9.13 CLN8 DOCK7 MFSD8
2 vision/eye MP:0005391 9.02 CLN8 DOCK7 MFSD8 PRNP PTPN23

Drugs & Therapeutics for Visual Cortex Disease

Drugs for Visual Cortex Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 3 7487-88-9 24083
2
Calcium Approved, Nutraceutical Phase 3 7440-70-2 271
3 Central Nervous System Depressants Phase 3
4 Peripheral Nervous System Agents Phase 3
5 Tocolytic Agents Phase 3
6 Anti-Arrhythmia Agents Phase 3
7 Hormones Phase 3
8 calcium channel blockers Phase 3
9 Anesthetics Phase 3
10 Analgesics Phase 3
11 Calcium, Dietary Phase 3
12 Anticonvulsants Phase 3
13 Hematinics Phase 2, Phase 3,Phase 3
14 Epoetin alfa Phase 2, Phase 3,Phase 3 113427-24-0

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy Study of Hypothermia Plus Magnesium Sulphate(MgSO4) in the Management of Term and Near Term Babies With Hypoxic Ischemic Encephalopathy Unknown status NCT01646619 Phase 3 Magnesium Sulphate;Placebo
2 Neuroprotective Role of Erythropoietin in Perinatal Asphyxia Completed NCT02002039 Phase 2, Phase 3 Erythropoietin
3 PAEAN - Erythropoietin for Hypoxic Ischaemic Encephalopathy in Newborns Recruiting NCT03079167 Phase 3 Epoetin Alfa;Normal saline
4 Cortical Visual Impairment and Visual Attentiveness Completed NCT00342108 Not Applicable
5 TOBY (TOtal Body hYpothermia): a Study of Treatment for Perinatal Asphyxia Completed NCT00147030 Not Applicable
6 CoolCap Trial, Treatment of Perinatal Hypoxic-Ischemic Encephalopathy Completed NCT00383305 Not Applicable

Search NIH Clinical Center for Visual Cortex Disease

Genetic Tests for Visual Cortex Disease

Anatomical Context for Visual Cortex Disease

MalaCards organs/tissues related to Visual Cortex Disease:

42
Cortex, Eye

Publications for Visual Cortex Disease

Variations for Visual Cortex Disease

Expression for Visual Cortex Disease

Search GEO for disease gene expression data for Visual Cortex Disease.

Pathways for Visual Cortex Disease

GO Terms for Visual Cortex Disease

Biological processes related to Visual Cortex Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nervous system development GO:0007399 9.13 CLN8 DOCK7 TIMM8A
2 lysosome organization GO:0007040 8.32 MFSD8

Sources for Visual Cortex Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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