MCID: VTM021
MIFTS: 13

Vitamin K Antagonists Toxicity or Dose Selection

Categories: Rare diseases

Aliases & Classifications for Vitamin K Antagonists Toxicity or Dose Selection

MalaCards integrated aliases for Vitamin K Antagonists Toxicity or Dose Selection:

Name: Vitamin K Antagonists Toxicity or Dose Selection 60

Classifications:



External Ids:

Orphanet 60 ORPHA413674

Summaries for Vitamin K Antagonists Toxicity or Dose Selection

MalaCards based summary : Vitamin K Antagonists Toxicity or Dose Selection is related to diffuse alveolar hemorrhage and phenytoin toxicity. Among its related pathways/superpathways are Arachidonic acid metabolism and Linoleic acid metabolism.

Related Diseases for Vitamin K Antagonists Toxicity or Dose Selection

Diseases related to Vitamin K Antagonists Toxicity or Dose Selection via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 diffuse alveolar hemorrhage 9.8 CYP2C9 VKORC1
2 phenytoin toxicity 9.7 CYP2C9 VKORC1
3 atrial fibrillation 9.4 CYP4F2 VKORC1
4 coumarin resistance 9.4 CYP2C9 CYP4F2 VKORC1

Symptoms & Phenotypes for Vitamin K Antagonists Toxicity or Dose Selection

Drugs & Therapeutics for Vitamin K Antagonists Toxicity or Dose Selection

Search Clinical Trials , NIH Clinical Center for Vitamin K Antagonists Toxicity or Dose Selection

Genetic Tests for Vitamin K Antagonists Toxicity or Dose Selection

Anatomical Context for Vitamin K Antagonists Toxicity or Dose Selection

Publications for Vitamin K Antagonists Toxicity or Dose Selection

Variations for Vitamin K Antagonists Toxicity or Dose Selection

Expression for Vitamin K Antagonists Toxicity or Dose Selection

Search GEO for disease gene expression data for Vitamin K Antagonists Toxicity or Dose Selection.

Pathways for Vitamin K Antagonists Toxicity or Dose Selection

GO Terms for Vitamin K Antagonists Toxicity or Dose Selection

Cellular components related to Vitamin K Antagonists Toxicity or Dose Selection according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum GO:0005783 9.43 CYP2C9 CYP4F2 VKORC1
2 endoplasmic reticulum membrane GO:0005789 9.33 CYP2C9 CYP4F2 VKORC1
3 organelle membrane GO:0031090 8.96 CYP2C9 CYP4F2
4 intracellular membrane-bounded organelle GO:0043231 8.8 CYP2C9 CYP4F2 VKORC1

Biological processes related to Vitamin K Antagonists Toxicity or Dose Selection according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.43 CYP2C9 CYP4F2 VKORC1
2 blood coagulation GO:0007596 9.32 CYP4F2 VKORC1
3 epoxygenase P450 pathway GO:0019373 9.16 CYP2C9 CYP4F2
4 omega-hydroxylase P450 pathway GO:0097267 8.96 CYP2C9 CYP4F2
5 drug metabolic process GO:0017144 8.8 CYP2C9 CYP4F2 VKORC1

Molecular functions related to Vitamin K Antagonists Toxicity or Dose Selection according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 9.37 CYP2C9 CYP4F2
2 iron ion binding GO:0005506 9.32 CYP2C9 CYP4F2
3 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.26 CYP2C9 CYP4F2
4 monooxygenase activity GO:0004497 9.16 CYP2C9 CYP4F2
5 oxidoreductase activity GO:0016491 9.13 CYP2C9 CYP4F2 VKORC1
6 arachidonic acid epoxygenase activity GO:0008392 8.62 CYP2C9 CYP4F2

Sources for Vitamin K Antagonists Toxicity or Dose Selection

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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