MCID: VTM033
MIFTS: 47

Vitamin K Deficiency Bleeding

Categories: Blood diseases, Gastrointestinal diseases, Metabolic diseases

Aliases & Classifications for Vitamin K Deficiency Bleeding

MalaCards integrated aliases for Vitamin K Deficiency Bleeding:

Name: Vitamin K Deficiency Bleeding 12 15
Vitamin K Deficiency 12 56 45
Vitamin K Deficiency Hemorrhagic Disease 12
Deficiency of Vitamin K 12
Vitamin K 44

Classifications:



External Ids:

Disease Ontology 12 DOID:11249
ICD9CM 36 269.0
MeSH 45 D014813
NCIt 51 C99108
SNOMED-CT 69 52675005
ICD10 34 E56.1
UMLS 74 C0042880

Summaries for Vitamin K Deficiency Bleeding

MedlinePlus : 44 Vitamins are substances that your body needs to grow and develop normally. Vitamin K helps your body by making proteins for healthy bones and tissues. It also makes proteins for blood clotting. If you don't have enough vitamin K, you may bleed too much. Newborns have very little vitamin K. They usually get a shot of vitamin K soon after they are born. If you take blood thinners, you need to be careful about how much vitamin K you get. You also need to be careful about taking vitamin E supplements. Vitamin E can interfere with how vitamin K works in your body. Ask your health care provider for recommendations about these vitamins. There are different types of vitamin K. Most people get vitamin K from plants such as green vegetables, and dark berries. Bacteria in your intestines also produce small amounts of another type of vitamin K.

MalaCards based summary : Vitamin K Deficiency Bleeding, also known as vitamin k deficiency, is related to hereditary combined deficiency of vitamin k-dependent clotting factors and factor vii deficiency. An important gene associated with Vitamin K Deficiency Bleeding is F2 (Coagulation Factor II, Thrombin), and among its related pathways/superpathways are Formation of Fibrin Clot (Clotting Cascade) and Complement and coagulation cascades. The drugs Phylloquinone and Menadione have been mentioned in the context of this disorder. Affiliated tissues include bone, kidney and brain, and related phenotypes are homeostasis/metabolism and mortality/aging

Disease Ontology : 12 A nutritional deficiency disease that is characterized by easy bleeding due to an inability to form blood clots caused by vitamin K deficiency, occurs most commonly in newborns, and has material basis in deficiency of vitamin K secondary to liver prematurity, lack of vitamin K in a breastmillk diet, largely sterile gut, malabsorption, diarrhea, chronic illness, menorrhagia, chronic kidney disease, and some medications.

Wikipedia : 77 Vitamin K deficiency results from insufficient dietary vitamin K1 or vitamin K2 or... more...

Related Diseases for Vitamin K Deficiency Bleeding

Diseases related to Vitamin K Deficiency Bleeding via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 249)
# Related Disease Score Top Affiliating Genes
1 hereditary combined deficiency of vitamin k-dependent clotting factors 33.8 GGCX VKORC1
2 factor vii deficiency 32.3 F2 F8
3 hemophilia b 31.9 F2 F8
4 protein s deficiency 31.7 F2 PROS1
5 hemorrhagic disease 30.5 F2 F8
6 prothrombin deficiency 30.3 F2 GGCX
7 thrombophilia due to thrombin defect 30.1 F2 F8
8 hemarthrosis 30.0 BGLAP F8
9 retinal vein occlusion 29.9 F2 VKORC1
10 purpura 29.9 F2 PROS1
11 factor viii deficiency 29.8 F2 F8
12 portal vein thrombosis 29.8 AFP F2
13 retinal vascular occlusion 29.8 F2 VKORC1
14 post-thrombotic syndrome 29.8 F2 F8
15 hemophilia 29.8 F2 F8
16 thrombophilia due to activated protein c resistance 29.7 F2 F8
17 biliary tract disease 29.7 AFP F2
18 alcoholic liver cirrhosis 29.6 AFP F2
19 purpura fulminans 29.5 F2 PROS1
20 thrombosis 29.5 F2 F8 PROS1
21 pseudoxanthoma elasticum 29.5 GGCX MGP VKORC1
22 thrombophilia 29.3 F2 F8 PROS1
23 hereditary resistance to anti-vitamin k 12.3
24 vitamin k antagonists toxicity or dose selection 12.3
25 resistance to vitamin k antagonists 12.3
26 vitamin k-dependent clotting factors, combined deficiency of, 1 11.9
27 vitamin k-dependent clotting factors, combined deficiency of, 2 11.9
28 maxillonasal dysplasia, binder type 11.5
29 neonatal adrenoleukodystrophy 11.3
30 pseudoxanthoma elasticum-like disorder with multiple coagulation factor deficiency 11.3
31 factor x deficiency 11.2
32 congenital disorder of glycosylation, type iil 11.2
33 protein c deficiency 11.2
34 chondrodysplasia punctata, autosomal dominant 11.1
35 galactosemia 11.1
36 cholestasis, progressive familial intrahepatic, 5 11.1
37 x-linked chondrodysplasia punctata 1 11.1
38 atrial fibrillation 10.7
39 endometrial small cell carcinoma 10.2 AFP F2
40 esophageal varix 10.2 AFP F2
41 fournier gangrene 10.2 F2 F8
42 brachydactyly, type d 10.2 F2 F8
43 alcohol-related birth defect 10.2 F2 F8
44 von willebrand disease, type 1 10.2 F2 F8
45 peliosis hepatis 10.2 AFP F2
46 cardiac tamponade 10.2 F2 F8
47 hepatic vascular disease 10.2 AFP F2
48 livedoid vasculitis 10.2 F2 F8
49 biliary atresia 10.2
50 thrombophlebitis 10.2 F2 F8

Graphical network of the top 20 diseases related to Vitamin K Deficiency Bleeding:



Diseases related to Vitamin K Deficiency Bleeding

Symptoms & Phenotypes for Vitamin K Deficiency Bleeding

MGI Mouse Phenotypes related to Vitamin K Deficiency Bleeding:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.5 AFP F2 F8 GGCX MGP PROS1
2 mortality/aging MP:0010768 9.17 AFP F2 F8 GGCX MGP PROS1

Drugs & Therapeutics for Vitamin K Deficiency Bleeding

Drugs for Vitamin K Deficiency Bleeding (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Phylloquinone Approved, Investigational Phase 3,Phase 1,Phase 2,Not Applicable 84-80-0
2
Menadione Approved, Nutraceutical Phase 3,Phase 1,Phase 2,Not Applicable 58-27-5 4055
3 Antifibrinolytic Agents Phase 3,Phase 1,Phase 2,Not Applicable
4 Coagulants Phase 3,Phase 1,Phase 2,Not Applicable
5 Vitamin MK 7 Phase 3,Phase 1,Phase 2,Not Applicable
6 Nutrients Phase 3,Phase 1,Phase 2,Not Applicable
7 naphthoquinone Phase 3,Phase 1,Phase 2,Not Applicable
8 Trace Elements Phase 3,Phase 1,Phase 2,Not Applicable
9 Vitamin K Phase 3,Phase 1,Phase 2,Not Applicable
10 Vitamins Phase 3,Phase 1,Phase 2,Not Applicable
11 Micronutrients Phase 3,Phase 1,Phase 2,Not Applicable
12 Menaquinone Phase 3,Phase 1,Phase 2,Not Applicable
13 Vitamin K 2 Phase 3,Phase 1,Phase 2,Not Applicable
14 Hemostatics Phase 3,Phase 1,Phase 2,Not Applicable
15
Thrombin Approved, Investigational
16
Glycerol Approved, Investigational 56-81-5 753
17
Calcium Approved, Nutraceutical Not Applicable 7440-70-2 271
18
Vitamin D Approved, Nutraceutical, Vet_approved Not Applicable 1406-16-2
19
Vitamin D3 Approved, Nutraceutical Not Applicable 67-97-0 5280795 6221
20
Ergocalciferol Approved, Nutraceutical Not Applicable 50-14-6 5280793
21 Vitamin K 1
22 Calcium, Dietary Not Applicable
23 Hormones Not Applicable
24 Ergocalciferols Not Applicable
25 Vitamin D2 Not Applicable
26 Calciferol Not Applicable
27 Bone Density Conservation Agents Not Applicable
28 4-phenylbutyric acid
29 Protective Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Vitamin K2 Supplementation to Activate Matrix Gla Protein (MGP) as Endogenous Inhibitor of Vascular Calcification in Hemodialysis Patients Completed NCT01407601 Phase 3
2 Effect of Vitamin K on Age-Related Bone Loss and Vascular Calcification Completed NCT00183001 Phase 3 Vitamin K
3 Vitamin K to Slow Progression of Cardiovascular Disease Risk in Hemodialysis Patients Recruiting NCT03311321 Phase 1, Phase 2
4 Treatment to Reduce Vascular Calcification In Hemodialysis Patients Using Vitamin K Active, not recruiting NCT02870829 Phase 2 menaquinone-7
5 Effect of Vitamin K in Critically Ill Patients Recruiting NCT03782025 Phytomenadione
6 Underlying Causes of Low Vitamin K Status in Hemodialysis Patients Recruiting NCT03493087 Not Applicable
7 The Effects of Vitamin K2 Supplementation on the Progression of Coronary Artery Calcification Active, not recruiting NCT01002157 Not Applicable
8 The Vitamin K2 and D3 Intervention Trial in Children and Adolescents With the Low-energy Fractures Not yet recruiting NCT03871322 Not Applicable
9 Expanded Access Protocol for an Intermediate Size Population - RAVICTI for Byler Disease No longer available NCT02094222 RAVICTI

Search NIH Clinical Center for Vitamin K Deficiency Bleeding

Cochrane evidence based reviews: vitamin k deficiency

Genetic Tests for Vitamin K Deficiency Bleeding

Anatomical Context for Vitamin K Deficiency Bleeding

MalaCards organs/tissues related to Vitamin K Deficiency Bleeding:

42
Bone, Kidney, Brain, Testes, Bone Marrow, Skin, Pancreas

Publications for Vitamin K Deficiency Bleeding

Articles related to Vitamin K Deficiency Bleeding:

(show top 50) (show all 379)
# Title Authors Year
1
Vitamin K deficiency bleeding in an apparently healthy newborn infant: the compelling need for evidence-based recommendation. ( 30832683 )
2019
2
Vitamin K Deficiency in Patients After Restorative Proctocolectomy. ( 29846595 )
2019
3
Vitamin K deficiency in critical ill patients; a prospective observational study. ( 30415179 )
2019
4
Prevalence of vitamin K deficiency in older people with hip fracture. ( 30618350 )
2019
5
X-Linked Chronic Granulomatous Disease: Initial Presentation with Intracranial Hemorrhage from Vitamin K Deficiency in Infant. ( 30034904 )
2018
6
Prevalence of vitamin K deficiency and associated factors in non-supplemented cystic fibrosis patients. ( 29333815 )
2018
7
Fetal intracranial hemorrhage due to maternal subclinical vitamin K deficiency associated with long-term eating disorder. ( 30255653 )
2018
8
Neonatal vitamin K deficiency in the son of a mother with short bowel syndrome. ( 30298697 )
2018
9
Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates. ( 29401369 )
2018
10
Transdermal delivery of vitamin K using dissolving microneedles for the prevention of vitamin K deficiency bleeding. ( 29471143 )
2018
11
Estimated costs for treatment and prophylaxis of newborn vitamin K deficiency bleeding in Tashkent, Uzbekistan. ( 29581610 )
2018
12
Pharmacogenetic variants and vitamin K deficiency: a risk factor or trigger for fibrosing interstitial pneumonias? ( 29538081 )
2018
13
Late-Onset Vitamin K Deficiency Presenting as Scrotal Bruising and Mediastinal Mass. ( 29538265 )
2018
14
Vitamin K deficiency: a case report and review of current guidelines. ( 29540231 )
2018
15
Controllable vitamin K deficiency under high-dose oral menatetrenone administration - a case report. ( 29609692 )
2018
16
Review on Vitamin K Deficiency and its Biomarkers: Focus on the Novel Application of PIVKA-II in Clinical Practice. ( 29739078 )
2018
17
A rare case of fetal extensive intracranial hemorrhage and whole-cerebral hypoplasia due to latent maternal vitamin K deficiency. ( 29843264 )
2018
18
Neonatal Cerebellar Hemorrhage Due to Vitamin K Deficiency. ( 29968560 )
2018
19
Vitamin K Deficiency Induced by Warfarin Is Associated With Cognitive and Behavioral Perturbations, and Alterations in Brain Sphingolipids in Rats. ( 30061825 )
2018
20
Genetic Polymorphism of VKORC1-1639 in Children With Intracranial Hemorrhage Due to Vitamin K Deficiency. ( 30099920 )
2018
21
Intrahepatic Cholestasis of Pregnancy Leading to Severe Vitamin K Deficiency and Coagulopathy. ( 28680707 )
2017
22
Coagulopathy secondary to vitamin K deficiency caused by severe diarrhea. ( 29804618 )
2017
23
The Presentation of a Fussy Infant With Bruising: Late-Onset Vitamin K Deficiency Bleeding. ( 28225379 )
2017
24
Detection of subclinical vitamin K deficiency in neurosurgery with PIVKA-II. ( 28319421 )
2017
25
K-alcification Protection in Dialysis Patients: The Underestimated Phenomenon of Vitamin K Deficiency. ( 28373275 )
2017
26
Finding the optimal dose of vitamin K1 to treat vitamin K deficiency and to avoid anaphylactoid reactions. ( 28407450 )
2017
27
Progressive Fetal Subdural Hematoma Associated With Maternal Vitamin K Deficiency: Prenatal Diagnosis and Neurologically Favorable Prognosis. ( 28480584 )
2017
28
Nonhealing, progressive stress fractures of the foot in a 13-year-old basketball player: is vitamin K deficiency a risk factor? ( 28533626 )
2017
29
Acquired Vitamin K Deficiency as Unusual Cause of Bleeding Tendency in Adults: A Case Report of a Nonhospitalized Student Presenting with Severe Menorrhagia. ( 28928999 )
2017
30
Vitamin K deficiency: the linking pin between COPD and cardiovascular diseases? ( 29132356 )
2017
31
Vitamin K Deficiency in Chronic Kidney Disease: Evidence Is Building Up. ( 27842304 )
2017
32
Vitamin K Deficiency Presenting in an Infant with an Anterior Mediastinal Mass: A Case Report and Review of the Literature. ( 28280644 )
2017
33
Prevention of Vitamin K Deficiency Bleeding in Newborn Infants: A Position Paper by the ESPGHAN Committee on Nutrition. ( 27050049 )
2016
34
Vitamin K prophylaxis for prevention of vitamin K deficiency bleeding: a systematic review. ( 27109090 )
2016
35
A Blown Pupil and Intracranial Hemorrhage in a 4-Week-Old: A Case of Delayed Onset Vitamin K Deficiency Bleeding, a Rare "Can't Miss" Diagnosis. ( 27301668 )
2016
36
Prevention of Vitamin K Deficiency Bleeding. ( 27389610 )
2016
37
Unusual presentation of late vitamin K deficiency bleeding in an infant. ( 28050096 )
2016
38
Vitamin K deficiency leads to exacerbation of murine dextran sulfate sodium-induced colitis. ( 26314836 )
2016
39
Management of vitamin K deficiency after biliopancreatic diversion with or without duodenal switch. ( 26826922 )
2016
40
Biological Systems of Vitamin K: A Plasma Nutriproteomics Study of Subclinical Vitamin K Deficiency in 500 Nepalese Children. ( 26913649 )
2016
41
Establishing a rat model for the study of vitamin K deficiency. ( 27256579 )
2016
42
Gastrointestinal bleeding secondary to trimethoprim-sulfamethoxazole-induced vitamin K deficiency. ( 27268289 )
2016
43
Correction: Gastrointestinal bleeding secondary to trimethoprim-sulfamethoxazole-induced vitamin K deficiency. ( 27340082 )
2016
44
Intraperitoneal Hemorrhage in a Pregnant Woman with Hyperemesis Gravidarum: Vitamin K Deficiency as a Possible Cause. ( 27597910 )
2016
45
Vitamin K deficiency evaluated by serum levels of undercarboxylated osteocalcin in patients with anorexia nervosa with bone loss. ( 24909585 )
2015
46
It's not just a vitamin: comment on "Rise in late onset vitamin K deficiency bleeding in young infants because of omission or refusal of prophylaxis at birth" by Schulte and colleagues. ( 25553862 )
2015
47
Are Pediatricians Complicit in Vitamin K Deficiency Bleeding? ( 26371205 )
2015
48
Prothrombin Complex Concentrate for Intracerebral Hemorrhage Secondary to Vitamin K Deficiency Bleeding in a 6-Week-Old Child. ( 26454577 )
2015
49
Early Vitamin K Deficiency Bleeding in a Neonate Associated with Maternal Acute Fatty Liver of Pregnancy. ( 26495183 )
2015
50
A case of maternal vitamin K deficiency associated with hyperemesis gravidarum: its potential impact on fetal blood coagulability. ( 25797877 )
2015

Variations for Vitamin K Deficiency Bleeding

Expression for Vitamin K Deficiency Bleeding

Search GEO for disease gene expression data for Vitamin K Deficiency Bleeding.

Pathways for Vitamin K Deficiency Bleeding

Pathways related to Vitamin K Deficiency Bleeding according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.63 F2 F8 PROS1
2 11.47 F2 F8 PROS1
3 11.35 AFP BGLAP
4
Show member pathways
11.29 BGLAP F2 GGCX PROS1
5 11.05 AFP F2
6 10.9 BGLAP MGP
7
Show member pathways
10.68 GGCX VKORC1
8 10.28 BGLAP F2 GGCX MGP PROS1 VKORC1

GO Terms for Vitamin K Deficiency Bleeding

Cellular components related to Vitamin K Deficiency Bleeding according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.65 AFP BGLAP F2 F8 PROS1
2 extracellular region GO:0005576 9.63 AFP BGLAP F2 F8 MGP PROS1
3 platelet alpha granule lumen GO:0031093 9.32 F8 PROS1
4 Golgi lumen GO:0005796 9.13 BGLAP F2 PROS1
5 endoplasmic reticulum lumen GO:0005788 8.92 AFP BGLAP F2 F8

Biological processes related to Vitamin K Deficiency Bleeding according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 bone development GO:0060348 9.48 BGLAP VKORC1
2 acute-phase response GO:0006953 9.46 F2 F8
3 fibrinolysis GO:0042730 9.43 F2 PROS1
4 hemostasis GO:0007599 9.43 F2 F8 PROS1
5 regulation of bone mineralization GO:0030500 9.4 BGLAP MGP
6 blood coagulation, intrinsic pathway GO:0007597 9.37 F2 F8
7 ER to Golgi vesicle-mediated transport GO:0006888 9.26 BGLAP F2 F8 PROS1
8 peptidyl-glutamic acid carboxylation GO:0017187 9.16 GGCX VKORC1
9 regulation of blood coagulation GO:0030193 9.02 F2
10 blood coagulation GO:0007596 9.02 F2 F8 GGCX PROS1 VKORC1

Molecular functions related to Vitamin K Deficiency Bleeding according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.26 BGLAP F2 MGP PROS1
2 structural constituent of bone GO:0008147 8.62 BGLAP MGP

Sources for Vitamin K Deficiency Bleeding

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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