MCID: VTM001
MIFTS: 46

Vitamin K Deficiency Hemorrhagic Disease

Categories: Blood diseases, Metabolic diseases

Aliases & Classifications for Vitamin K Deficiency Hemorrhagic Disease

MalaCards integrated aliases for Vitamin K Deficiency Hemorrhagic Disease:

Name: Vitamin K Deficiency Hemorrhagic Disease 12 15
Vitamin K Deficiency 12 55 44 73
Deficiency of Vitamin K 12
Vitamin K 43

Classifications:



External Ids:

Disease Ontology 12 DOID:11249
ICD10 33 E56.1
ICD9CM 35 269.0
MeSH 44 D014813
NCIt 50 C99108
SNOMED-CT 68 52675005
UMLS 73 C0042880

Summaries for Vitamin K Deficiency Hemorrhagic Disease

MedlinePlus : 43 Vitamins are substances that your body needs to grow and develop normally. Vitamin K helps your body by making proteins for healthy bones and tissues. It also makes proteins for blood clotting. If you don't have enough vitamin K, you may bleed too much. Newborns have very little vitamin K. They usually get a shot of vitamin K soon after they are born. If you take blood thinners, you need to be careful about how much vitamin K you get. You also need to be careful about taking vitamin E supplements. Vitamin E can interfere with how vitamin K works in your body. Ask your health care provider for recommendations about these vitamins. There are different types of vitamin K. Most people get vitamin K from plants such as green vegetables, and dark berries. Bacteria in your intestines also produce small amounts of another type of vitamin K.

MalaCards based summary : Vitamin K Deficiency Hemorrhagic Disease, also known as vitamin k deficiency, is related to hereditary combined deficiency of vitamin k-dependent clotting factors and factor vii deficiency. An important gene associated with Vitamin K Deficiency Hemorrhagic Disease is F2 (Coagulation Factor II, Thrombin), and among its related pathways/superpathways are Formation of Fibrin Clot (Clotting Cascade) and Complement and coagulation cascades. Affiliated tissues include bone, liver and kidney, and related phenotypes are homeostasis/metabolism and mortality/aging

Wikipedia : 76 Vitamin K deficiency results from insufficient dietary vitamin K1 or vitamin K2 or... more...

Related Diseases for Vitamin K Deficiency Hemorrhagic Disease

Diseases related to Vitamin K Deficiency Hemorrhagic Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 215)
# Related Disease Score Top Affiliating Genes
1 hereditary combined deficiency of vitamin k-dependent clotting factors 33.7 GGCX VKORC1
2 factor vii deficiency 32.2 F2 F8
3 prothrombin deficiency 32.0 F2 GGCX
4 hemophilia b 31.8 F2 F8
5 protein s deficiency 31.8 F2 PROS1
6 purpura 30.2 F2 PROS1
7 hemorrhagic disease 30.2 F2 F8
8 thrombophilia due to thrombin defect 30.0 F2 F8
9 hemarthrosis 29.9 BGLAP F8
10 retinal vein occlusion 29.7 F2 VKORC1
11 factor viii deficiency 29.7 F2 F8
12 portal vein thrombosis 29.7 AFP F2
13 post-thrombotic syndrome 29.7 F2 F8
14 hemophilia 29.7 F2 F8
15 purpura fulminans 29.6 F2 PROS1
16 thrombophilia due to activated protein c resistance 29.6 F2 F8
17 biliary tract disease 29.6 AFP F2
18 alcoholic liver cirrhosis 29.6 AFP F2
19 thrombosis 29.5 F2 F8 PROS1
20 retinal vascular occlusion 29.5 F2 VKORC1
21 pseudoxanthoma elasticum 29.4 GGCX MGP VKORC1
22 thrombophilia 29.4 F2 F8 PROS1
23 hereditary resistance to anti-vitamin k 12.3
24 vitamin k antagonists toxicity or dose selection 12.3
25 resistance to vitamin k antagonists 12.3
26 vitamin k-dependent clotting factors, combined deficiency of, 1 11.8
27 vitamin k-dependent clotting factors, combined deficiency of, 2 11.8
28 maxillonasal dysplasia, binder type 11.5
29 neonatal adrenoleukodystrophy 11.3
30 pseudoxanthoma elasticum-like disorder with multiple coagulation factor deficiency 11.2
31 factor x deficiency 11.2
32 congenital disorder of glycosylation, type iil 11.2
33 protein c deficiency 11.2
34 galactosemia 11.1
35 cholestasis, progressive familial intrahepatic, 5 11.1
36 atrial fibrillation 10.5
37 cystic fibrosis 10.2
38 endometrial small cell carcinoma 10.2 AFP F2
39 esophageal varix 10.1 AFP F2
40 crohn's disease 10.1
41 biliary atresia 10.1
42 fournier gangrene 10.1 F2 F8
43 brachydactyly, type d 10.1 F2 F8
44 alcohol-related birth defect 10.1 F2 F8
45 von willebrand disease, type 1 10.1 F2 F8
46 peliosis hepatis 10.1 AFP F2
47 cardiac tamponade 10.1 F2 F8
48 hepatic vascular disease 10.1 AFP F2
49 livedoid vasculitis 10.1 F2 F8
50 thrombophlebitis 10.1 F2 F8

Comorbidity relations with Vitamin K Deficiency Hemorrhagic Disease via Phenotypic Disease Network (PDN):


Acute Cystitis Familial Atrial Fibrillation
Heart Disease

Graphical network of the top 20 diseases related to Vitamin K Deficiency Hemorrhagic Disease:



Diseases related to Vitamin K Deficiency Hemorrhagic Disease

Symptoms & Phenotypes for Vitamin K Deficiency Hemorrhagic Disease

MGI Mouse Phenotypes related to Vitamin K Deficiency Hemorrhagic Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.5 AFP F2 F8 GGCX MGP PROS1
2 mortality/aging MP:0010768 9.17 AFP F2 F8 GGCX MGP PROS1

Drugs & Therapeutics for Vitamin K Deficiency Hemorrhagic Disease

Search Clinical Trials , NIH Clinical Center for Vitamin K Deficiency Hemorrhagic Disease

Cochrane evidence based reviews: vitamin k deficiency

Genetic Tests for Vitamin K Deficiency Hemorrhagic Disease

Anatomical Context for Vitamin K Deficiency Hemorrhagic Disease

MalaCards organs/tissues related to Vitamin K Deficiency Hemorrhagic Disease:

41
Bone, Liver, Kidney, Brain, Lung, Heart, Prostate

Publications for Vitamin K Deficiency Hemorrhagic Disease

Articles related to Vitamin K Deficiency Hemorrhagic Disease:

(show top 50) (show all 377)
# Title Authors Year
1
Vitamin K deficiency in critical ill patients; a prospective observational study. ( 30415179 )
2019
2
X-Linked Chronic Granulomatous Disease: Initial Presentation with Intracranial Hemorrhage from Vitamin K Deficiency in Infant. ( 30034904 )
2018
3
Prevalence of vitamin K deficiency and associated factors in non-supplemented cystic fibrosis patients. ( 29333815 )
2018
4
Fetal intracranial hemorrhage due to maternal subclinical vitamin K deficiency associated with long-term eating disorder. ( 30255653 )
2018
5
Neonatal vitamin K deficiency in the son of a mother with short bowel syndrome. ( 30298697 )
2018
6
Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates. ( 29401369 )
2018
7
Transdermal delivery of vitamin K using dissolving microneedles for the prevention of vitamin K deficiency bleeding. ( 29471143 )
2018
8
Pharmacogenetic variants and vitamin K deficiency: a risk factor or trigger for fibrosing interstitial pneumonias? ( 29538081 )
2018
9
Late-Onset Vitamin K Deficiency Presenting as Scrotal Bruising and Mediastinal Mass. ( 29538265 )
2018
10
Vitamin K deficiency: a case report and review of current guidelines. ( 29540231 )
2018
11
Estimated costs for treatment and prophylaxis of newborn vitamin K deficiency bleeding in Tashkent, Uzbekistan. ( 29581610 )
2018
12
Controllable vitamin K deficiency under high-dose oral menatetrenone administration - a case report. ( 29609692 )
2018
13
Review on Vitamin K Deficiency and its Biomarkers: Focus on the Novel Application of PIVKA-II in Clinical Practice. ( 29739078 )
2018
14
A rare case of fetal extensive intracranial hemorrhage and whole-cerebral hypoplasia due to latent maternal vitamin K deficiency. ( 29843264 )
2018
15
Vitamin K Deficiency in Patients After Restorative Proctocolectomy. ( 29846595 )
2018
16
Neonatal Cerebellar Hemorrhage Due to Vitamin K Deficiency. ( 29968560 )
2018
17
Vitamin K Deficiency Induced by Warfarin Is Associated With Cognitive and Behavioral Perturbations, and Alterations in Brain Sphingolipids in Rats. ( 30061825 )
2018
18
Genetic Polymorphism of VKORC1-1639 in Children With Intracranial Hemorrhage Due to Vitamin K Deficiency. ( 30099920 )
2018
19
Intrahepatic Cholestasis of Pregnancy Leading to Severe Vitamin K Deficiency and Coagulopathy. ( 28680707 )
2017
20
Coagulopathy secondary to vitamin K deficiency caused by severe diarrhea. ( 29804618 )
2017
21
K-alcification Protection in Dialysis Patients: The Underestimated Phenomenon of Vitamin K Deficiency. ( 28373275 )
2017
22
Finding the optimal dose of vitamin K1 to treat vitamin K deficiency and to avoid anaphylactoid reactions. ( 28407450 )
2017
23
Progressive Fetal Subdural Hematoma Associated With Maternal Vitamin K Deficiency: Prenatal Diagnosis and Neurologically Favorable Prognosis. ( 28480584 )
2017
24
Nonhealing, progressive stress fractures of the foot in a 13-year-old basketball player: is vitamin K deficiency a risk factor? ( 28533626 )
2017
25
Acquired Vitamin K Deficiency as Unusual Cause of Bleeding Tendency in Adults: A Case Report of a Nonhospitalized Student Presenting with Severe Menorrhagia. ( 28928999 )
2017
26
Vitamin K deficiency: the linking pin between COPD and cardiovascular diseases? ( 29132356 )
2017
27
Vitamin K Deficiency in Chronic Kidney Disease: Evidence Is Building Up. ( 27842304 )
2017
28
The Presentation of a Fussy Infant With Bruising: Late-Onset Vitamin K Deficiency Bleeding. ( 28225379 )
2017
29
Vitamin K Deficiency Presenting in an Infant with an Anterior Mediastinal Mass: A Case Report and Review of the Literature. ( 28280644 )
2017
30
Detection of subclinical vitamin K deficiency in neurosurgery with PIVKA-II. ( 28319421 )
2017
31
Vitamin K deficiency leads to exacerbation of murine dextran sulfate sodium-induced colitis. ( 26314836 )
2016
32
Management of vitamin K deficiency after biliopancreatic diversion with or without duodenal switch. ( 26826922 )
2016
33
Biological Systems of Vitamin K: A Plasma Nutriproteomics Study of Subclinical Vitamin K Deficiency in 500 Nepalese Children. ( 26913649 )
2016
34
Prevention of Vitamin K Deficiency Bleeding in Newborn Infants: A Position Paper by the ESPGHAN Committee on Nutrition. ( 27050049 )
2016
35
Vitamin K prophylaxis for prevention of vitamin K deficiency bleeding: a systematic review. ( 27109090 )
2016
36
Establishing a rat model for the study of vitamin K deficiency. ( 27256579 )
2016
37
Gastrointestinal bleeding secondary to trimethoprim-sulfamethoxazole-induced vitamin K deficiency. ( 27268289 )
2016
38
A Blown Pupil and Intracranial Hemorrhage in a 4-Week-Old: A Case of Delayed Onset Vitamin K Deficiency Bleeding, a Rare "Can't Miss" Diagnosis. ( 27301668 )
2016
39
Correction: Gastrointestinal bleeding secondary to trimethoprim-sulfamethoxazole-induced vitamin K deficiency. ( 27340082 )
2016
40
Prevention of Vitamin K Deficiency Bleeding. ( 27389610 )
2016
41
Intraperitoneal Hemorrhage in a Pregnant Woman with Hyperemesis Gravidarum: Vitamin K Deficiency as a Possible Cause. ( 27597910 )
2016
42
Unusual presentation of late vitamin K deficiency bleeding in an infant. ( 28050096 )
2016
43
Vitamin K deficiency evaluated by serum levels of undercarboxylated osteocalcin in patients with anorexia nervosa with bone loss. ( 24909585 )
2015
44
It's not just a vitamin: comment on "Rise in late onset vitamin K deficiency bleeding in young infants because of omission or refusal of prophylaxis at birth" by Schulte and colleagues. ( 25553862 )
2015
45
A case of maternal vitamin K deficiency associated with hyperemesis gravidarum: its potential impact on fetal blood coagulability. ( 25797877 )
2015
46
Vitamin K Deficiency Embryopathy from Hyperemesis Gravidarum. ( 26347836 )
2015
47
Are Pediatricians Complicit in Vitamin K Deficiency Bleeding? ( 26371205 )
2015
48
Prothrombin Complex Concentrate for Intracerebral Hemorrhage Secondary to Vitamin K Deficiency Bleeding in a 6-Week-Old Child. ( 26454577 )
2015
49
Early Vitamin K Deficiency Bleeding in a Neonate Associated with Maternal Acute Fatty Liver of Pregnancy. ( 26495183 )
2015
50
Neonatal Prophylaxis: Prevention of Vitamin K Deficiency Haemorrhage and Neonatal Ophthalmia. ( 27646726 )
2015

Variations for Vitamin K Deficiency Hemorrhagic Disease

Expression for Vitamin K Deficiency Hemorrhagic Disease

Search GEO for disease gene expression data for Vitamin K Deficiency Hemorrhagic Disease.

Pathways for Vitamin K Deficiency Hemorrhagic Disease

Pathways related to Vitamin K Deficiency Hemorrhagic Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.63 F2 F8 PROS1
2 11.47 F2 F8 PROS1
3 11.35 AFP BGLAP
4
Show member pathways
11.29 BGLAP F2 GGCX PROS1
5 11.05 AFP F2
6 10.9 BGLAP MGP
7
Show member pathways
10.68 GGCX VKORC1
8 10.28 BGLAP F2 GGCX MGP PROS1 VKORC1

GO Terms for Vitamin K Deficiency Hemorrhagic Disease

Cellular components related to Vitamin K Deficiency Hemorrhagic Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.65 AFP BGLAP F2 F8 PROS1
2 extracellular region GO:0005576 9.63 AFP BGLAP F2 F8 MGP PROS1
3 platelet alpha granule lumen GO:0031093 9.32 F8 PROS1
4 Golgi lumen GO:0005796 9.13 BGLAP F2 PROS1
5 endoplasmic reticulum lumen GO:0005788 8.92 AFP BGLAP F2 F8

Biological processes related to Vitamin K Deficiency Hemorrhagic Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 bone development GO:0060348 9.48 BGLAP VKORC1
2 acute-phase response GO:0006953 9.46 F2 F8
3 fibrinolysis GO:0042730 9.43 F2 PROS1
4 hemostasis GO:0007599 9.43 F2 F8 PROS1
5 regulation of bone mineralization GO:0030500 9.4 BGLAP MGP
6 blood coagulation, intrinsic pathway GO:0007597 9.37 F2 F8
7 regulation of blood coagulation GO:0030193 9.32 F2 VKORC1
8 ER to Golgi vesicle-mediated transport GO:0006888 9.26 BGLAP F2 F8 PROS1
9 peptidyl-glutamic acid carboxylation GO:0017187 9.16 GGCX VKORC1
10 blood coagulation GO:0007596 9.02 F2 F8 GGCX PROS1 VKORC1

Molecular functions related to Vitamin K Deficiency Hemorrhagic Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.26 BGLAP F2 MGP PROS1
2 structural constituent of bone GO:0008147 8.62 BGLAP MGP

Sources for Vitamin K Deficiency Hemorrhagic Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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