MCID: VTM001
MIFTS: 40

Vitamin K Deficiency Hemorrhagic Disease

Categories: Metabolic diseases

Aliases & Classifications for Vitamin K Deficiency Hemorrhagic Disease

MalaCards integrated aliases for Vitamin K Deficiency Hemorrhagic Disease:

Name: Vitamin K Deficiency Hemorrhagic Disease 12 15
Vitamin K Deficiency 12 55 44 73
Deficiency of Vitamin K 12
Vitamin K 43

Classifications:



External Ids:

Disease Ontology 12 DOID:11249
ICD10 33 E56.1
ICD9CM 35 269.0
MeSH 44 D014813
NCIt 50 C99108
SNOMED-CT 68 124892003 52675005
UMLS 73 C0042880

Summaries for Vitamin K Deficiency Hemorrhagic Disease

MedlinePlus : 43 Vitamins are substances that your body needs to grow and develop normally. Vitamin K helps your body by making proteins for healthy bones and tissues. It also makes proteins for blood clotting. If you don't have enough vitamin K, you may bleed too much. Newborns have very little vitamin K. They usually get a shot of vitamin K soon after they are born. If you take blood thinners, you need to be careful about how much vitamin K you get. You also need to be careful about taking vitamin E supplements. Vitamin E can interfere with how vitamin K works in your body. Ask your health care provider for recommendations about these vitamins. There are different types of vitamin K. Most people get vitamin K from plants such as green vegetables, and dark berries. Bacteria in your intestines also produce small amounts of another type of vitamin K.

MalaCards based summary : Vitamin K Deficiency Hemorrhagic Disease, also known as vitamin k deficiency, is related to hereditary combined deficiency of vitamin k-dependent clotting factors and factor vii deficiency. An important gene associated with Vitamin K Deficiency Hemorrhagic Disease is F2 (Coagulation Factor II, Thrombin), and among its related pathways/superpathways are Formation of Fibrin Clot (Clotting Cascade) and Complement and coagulation cascades. The drugs Menadione and Phytonadione have been mentioned in the context of this disorder. Affiliated tissues include bone, liver and lung, and related phenotypes are homeostasis/metabolism and mortality/aging

Wikipedia : 76 Vitamin K deficiency results from insufficient dietary vitamin K1 or vitamin K2 or... more...

Related Diseases for Vitamin K Deficiency Hemorrhagic Disease

Diseases related to Vitamin K Deficiency Hemorrhagic Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Related Disease Score Top Affiliating Genes
1 hereditary combined deficiency of vitamin k-dependent clotting factors 33.3 GGCX VKORC1
2 factor vii deficiency 32.3 F2 F8
3 prothrombin deficiency 32.2 F2 F8
4 hemorrhagic disease 30.0 F2 F8
5 vitamin k-dependent clotting factors, combined deficiency of, 1 11.7
6 vitamin k-dependent clotting factors, combined deficiency of, 2 11.7
7 maxillonasal dysplasia, binder type 11.4
8 factor x deficiency 11.0
9 congenital disorder of glycosylation, type iil 11.0
10 protein c deficiency 11.0
11 endometrial small cell carcinoma 10.5 AFP F2
12 esophageal varix 10.5 AFP F2
13 peliosis hepatis 10.5 AFP F2
14 portal vein thrombosis 10.5 AFP F2
15 fournier gangrene 10.4 F2 F8
16 hepatic vascular disease 10.4 AFP F2
17 von willebrand disease, type 1 10.4 F2 F8
18 alcohol-related birth defect 10.4 F2 F8
19 factor viii deficiency 10.4 F2 F8
20 retinal artery occlusion 10.4 F2 F8
21 cardiac tamponade 10.4 F2 F8
22 inherited blood coagulation disease 10.4 F2 F8
23 osteonecrosis 10.4 BGLAP F2
24 retinal vascular occlusion 10.4 F2 VKORC1
25 thrombophlebitis 10.4 F2 F8
26 hepatitis a 10.4 AFP F2
27 post-thrombotic syndrome 10.4 F2 F8
28 compartment syndrome 10.4 F2 F8
29 hemophilia 10.4 F2 F8
30 hemarthrosis 10.4 BGLAP F8
31 severe hemophilia a 10.4 F2 F8
32 hemophilia b 10.3 F2 F8
33 afibrinogenemia, congenital 10.3 F2 F8
34 placental insufficiency 10.3 AFP F2
35 retinal vein occlusion 10.3 F2 VKORC1
36 cerebral sinovenous thrombosis 10.3 F2 PROS1
37 blood coagulation disease 10.3 F2 F8
38 blood protein disease 10.3 F2 PROS1
39 thrombophilia due to activated protein c resistance 10.3 F2 F8
40 purpura fulminans 10.3 F2 PROS1
41 heart conduction disease 10.3 F2 VKORC1
42 afibrinogenemia 10.3 F2 F8
43 alcoholic liver cirrhosis 10.3 AFP F2
44 von willebrand's disease 10.3 F2 F8
45 protein s deficiency 10.2 F2 PROS1
46 factor v deficiency 10.2 F2 F8
47 thrombophilia due to thrombin defect 10.2 F2 F8
48 testicular yolk sac tumor 10.2 AFP F8
49 glanzmann thrombasthenia 10.1 F2 F8
50 nutritional deficiency disease 10.1 BGLAP F2 MGP

Comorbidity relations with Vitamin K Deficiency Hemorrhagic Disease via Phenotypic Disease Network (PDN):


Acute Cystitis Familial Atrial Fibrillation
Heart Disease

Graphical network of the top 20 diseases related to Vitamin K Deficiency Hemorrhagic Disease:



Diseases related to Vitamin K Deficiency Hemorrhagic Disease

Symptoms & Phenotypes for Vitamin K Deficiency Hemorrhagic Disease

MGI Mouse Phenotypes related to Vitamin K Deficiency Hemorrhagic Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.5 MGP PROS1 VKORC1 AFP F2 F8
2 mortality/aging MP:0010768 9.17 GGCX MGP PROS1 VKORC1 AFP F2

Drugs & Therapeutics for Vitamin K Deficiency Hemorrhagic Disease

Drugs for Vitamin K Deficiency Hemorrhagic Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Menadione Approved, Nutraceutical Phase 3,Phase 1,Phase 2,Not Applicable 58-27-5 4055
2
Phytonadione Approved, Investigational, Nutraceutical Phase 3,Phase 1,Phase 2,Not Applicable 84-80-0 4812 5284607
3 Antifibrinolytic Agents Phase 3,Phase 1,Phase 2,Not Applicable
4 Coagulants Phase 3,Phase 1,Phase 2,Not Applicable
5 Hemostatics Phase 3,Phase 1,Phase 2,Not Applicable
6 Micronutrients Phase 3,Phase 1,Phase 2,Not Applicable
7 Trace Elements Phase 3,Phase 1,Phase 2,Not Applicable
8 Vitamin K 2 Phase 3,Phase 1,Phase 2,Not Applicable
9 Vitamin MK 7 Phase 3,Phase 1,Phase 2,Not Applicable
10 Vitamins Phase 3,Phase 1,Phase 2,Not Applicable
11 Menaquinone Nutraceutical Phase 3,Phase 1,Phase 2,Not Applicable
12 naphthoquinone Nutraceutical Phase 3,Phase 1,Phase 2,Not Applicable
13 Vitamin K Nutraceutical Phase 3,Phase 1,Phase 2,Not Applicable
14
Glycerol Approved, Investigational 56-81-5 753
15 4-phenylbutyric acid
16 Protective Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Vitamin K2 Supplementation to Activate Matrix Gla Protein (MGP) as Endogenous Inhibitor of Vascular Calcification in Hemodialysis Patients Completed NCT01407601 Phase 3
2 Effect of Vitamin K on Age-Related Bone Loss and Vascular Calcification Completed NCT00183001 Phase 3 Vitamin K
3 Vitamin K to Slow Progression of Cardiovascular Disease Risk in Hemodialysis Patients Recruiting NCT03311321 Phase 1, Phase 2
4 Treatment to Reduce Vascular Calcification In Hemodialysis Patients Using Vitamin K Active, not recruiting NCT02870829 Phase 2 menaquinone-7
5 Underlying Causes of Low Vitamin K Status in Hemodialysis Patients Recruiting NCT03493087 Not Applicable
6 The Effects of Vitamin K2 Supplementation on the Progression of Coronary Artery Calcification Recruiting NCT01002157 Not Applicable
7 Expanded Access Protocol for an Intermediate Size Population - RAVICTI for Byler Disease Temporarily not available NCT02094222 RAVICTI

Search NIH Clinical Center for Vitamin K Deficiency Hemorrhagic Disease

Cochrane evidence based reviews: vitamin k deficiency

Genetic Tests for Vitamin K Deficiency Hemorrhagic Disease

Anatomical Context for Vitamin K Deficiency Hemorrhagic Disease

MalaCards organs/tissues related to Vitamin K Deficiency Hemorrhagic Disease:

41
Bone, Liver, Lung

Publications for Vitamin K Deficiency Hemorrhagic Disease

Articles related to Vitamin K Deficiency Hemorrhagic Disease:

(show top 50) (show all 54)
# Title Authors Year
1
Intrahepatic Cholestasis of Pregnancy Leading to Severe Vitamin K Deficiency and Coagulopathy. ( 28680707 )
2017
2
Vitamin K deficiency bleeding leading to the diagnosis of Crohn's disease. ( 25117110 )
2014
3
Vitamin k deficiency bleeding presenting as nodular purpura in infancy: a rare and life-threatening entity. ( 24082204 )
2013
4
Intracranial hemorrhage associated with vitamin K-deficiency bleeding in patients with biliary atresia: focus on long-term outcomes. ( 22124309 )
2012
5
Subdural hemorrhage: A unique case involving secondary vitamin K deficiency bleeding due to biliary atresia. ( 22607980 )
2012
6
Binder phenotype and brachytelephalangic chondrodysplasia punctata secondary to maternal vitamin K deficiency. ( 20177377 )
2010
7
Late vitamin K deficiency bleeding in an infant with choledochal cyst. ( 21428201 )
2010
8
Hydrolysed formula is a risk factor for vitamin K deficiency in infants with unrecognised cholestasis. ( 21057325 )
2010
9
Prevalence of subclinical vitamin K deficiency in cholestatic liver disease. ( 19502999 )
2009
10
Paraplegia: a rare manifestation of vitamin K deficiency. ( 19242045 )
2009
11
Vitamin K deficiency bleeding in cholestatic infants with alpha-1-antitrypsin deficiency. ( 19414430 )
2009
12
A study of the prevalence of vitamin K deficiency in patients with cancer referred to a hospital palliative care team and its association with abnormal haemostasis. ( 17923470 )
2008
13
Prevention of vitamin K deficiency bleeding in breastfed infants: lessons from the Dutch and Danish biliary atresia registries. ( 18381514 )
2008
14
Efficacy of high dose phylloquinone in correcting vitamin K deficiency in cystic fibrosis. ( 18511355 )
2008
15
Vitamin K deficiency from long-term warfarin anticoagulation does not alter skeletal status in male rhesus monkeys. ( 17295605 )
2007
16
[Suspicious case of epidural hematoma due to coagulopathy caused by vitamin K deficiency associated with antibiotics]. ( 17315736 )
2007
17
Celiac disease with diffuse cutaneous vitamin K-deficiency bleeding. ( 18165211 )
2007
18
Gray matter heterotopias and brachytelephalangic chondrodysplasia punctata: a complication of hyperemesis gravidarum induced vitamin K deficiency? ( 17163521 )
2007
19
Subclinical vitamin K deficiency in hemodialysis patients. ( 17336705 )
2007
20
Hemothorax as presentation of late vitamin-K-deficient bleeding in a 1-month-old infant with homozygous alpha-1-antitrypsin deficiency. ( 17124588 )
2007
21
Prevalence of vitamin K deficiency in children with mild to moderate chronic liver disease. ( 16385257 )
2006
22
Intracranial hemorrhage and vitamin K deficiency associated with biliary atresia: summary of 15 cases and review of the literature. ( 17047416 )
2006
23
Central diabetes insipidus following intracranial hemorrhage due to vitamin K deficiency in a neonate. ( 16302578 )
2005
24
Biliary lithiasis in early pregnancy and abnormal development of facial and distal limb bones (Binder syndrome): a possible role for vitamin K deficiency. ( 15751048 )
2005
25
Assessment of vitamin K deficiency in CF--how much sophistication is useful? ( 15463856 )
2003
26
Cervical spine stenosis and possible vitamin K deficiency embryopathy in an unusual case of chondrodysplasia punctata and an updated classification system. ( 12949976 )
2003
27
Intestinal absorption of mixed micellar phylloquinone (vitamin K1) is unreliable in infants with conjugated hyperbilirubinaemia: implications for oral prophylaxis of vitamin K deficiency bleeding. ( 12598499 )
2003
28
Vitamin K deficiency and osteopenia in vitamin D-deficient elderly women with Parkinson's disease. ( 11782837 )
2002
29
Vitamin K deficiency and D-dimer levels in the intensive care unit: a prospective cohort study. ( 11994567 )
2002
30
Treatment of vitamin K deficiency in cystic fibrosis: Effectiveness of a daily fat-soluble vitamin combination. ( 11391328 )
2001
31
Vitamin K deficiency in diarrhoea. ( 11338219 )
2001
32
Vitamin K administration to elderly patients with osteoporosis induces no hemostatic activation, even in those with suspected vitamin K deficiency. ( 11846334 )
2001
33
Are breast-fed infants vitamin K deficient? ( 11787707 )
2001
34
Fibroblast studies documenting a case of peroxisomal 2-methylacyl-CoA racemase deficiency: possible link between racemase deficiency and malabsorption and vitamin K deficiency. ( 11473573 )
2001
35
Vitamin K deficiency in diffuse alveolar hemorrhage associated with systemic lupus erythematosus. ( 11786727 )
2001
36
Severe acquired vitamin K deficiency: a hypothesis for rapid response to therapy. ( 10870812 )
2000
37
Vitamin K deficiency and osteopenia in disuse-affected limbs of vitamin D-deficient elderly stroke patients. ( 10418836 )
1999
38
Prevalence of vitamin K deficiency in cystic fibrosis. ( 10479200 )
1999
39
VITAMIN K DEFICIENCY HEMORRHAGIC DISEASE OF NEWBORN AND PRESENT CONTROVERSIES. ( 28775544 )
1998
40
Hemorrhagic disease in an infant fed on a vitamin K-deficient soya formula. ( 8956177 )
1996
41
Vitamin K-dependent carboxylase: mRNA distribution and effects of vitamin K-deficiency and warfarin treatment. ( 8702425 )
1996
42
Vitamin K deficiency bleeding in infants and children. ( 8588159 )
1995
43
The extent of vitamin K deficiency in patients with cholestatic jaundice: a preliminary communication. ( 8046700 )
1994
44
Evaluation of a daily dose of 25 micrograms vitamin K1 to prevent vitamin K deficiency in breast-fed infants. ( 8492260 )
1993
45
Evidence of vitamin K deficiency in cord blood. ( 7886551 )
1993
46
Vitamin K deficiency. ( 7886607 )
1993
47
Dietary induced subclinical vitamin K deficiency in normal human subjects. ( 8473516 )
1993
48
Hemolytic uremic syndrome complicated by vitamin K deficiency. ( 2069228 )
1991
49
Vitamin K deficiency presenting with hemarthrosis. ( 6490891 )
1984
50
Warfarin inhibits both procoagulant activity and metastatic capacity of Lewis lung carcinoma cells. Role of vitamin K deficiency. ( 6870908 )
1983

Variations for Vitamin K Deficiency Hemorrhagic Disease

Expression for Vitamin K Deficiency Hemorrhagic Disease

Search GEO for disease gene expression data for Vitamin K Deficiency Hemorrhagic Disease.

Pathways for Vitamin K Deficiency Hemorrhagic Disease

Pathways related to Vitamin K Deficiency Hemorrhagic Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.63 F2 F8 PROS1
2 11.47 F2 F8 PROS1
3 11.35 AFP BGLAP
4
Show member pathways
11.29 BGLAP F2 GGCX PROS1
5 11.05 AFP F2
6 10.9 BGLAP MGP
7
Show member pathways
10.68 GGCX VKORC1
8 10.28 BGLAP F2 GGCX MGP PROS1 VKORC1

GO Terms for Vitamin K Deficiency Hemorrhagic Disease

Cellular components related to Vitamin K Deficiency Hemorrhagic Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.65 AFP BGLAP F2 F8 PROS1
2 extracellular region GO:0005576 9.63 AFP BGLAP F2 F8 MGP PROS1
3 platelet alpha granule lumen GO:0031093 9.32 F8 PROS1
4 Golgi lumen GO:0005796 9.13 BGLAP F2 PROS1
5 endoplasmic reticulum lumen GO:0005788 8.92 AFP BGLAP F2 F8

Biological processes related to Vitamin K Deficiency Hemorrhagic Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ER to Golgi vesicle-mediated transport GO:0006888 9.56 BGLAP F2 F8 PROS1
2 hemostasis GO:0007599 9.5 F2 F8 PROS1
3 bone development GO:0060348 9.48 BGLAP VKORC1
4 acute-phase response GO:0006953 9.46 F2 F8
5 regulation of bone mineralization GO:0030500 9.43 BGLAP MGP
6 fibrinolysis GO:0042730 9.4 F2 PROS1
7 blood coagulation, intrinsic pathway GO:0007597 9.37 F2 F8
8 blood coagulation GO:0007596 9.35 F2 F8 GGCX PROS1 VKORC1
9 signal peptide processing GO:0006465 9.33 BGLAP F2 PROS1
10 peptidyl-glutamic acid carboxylation GO:0017187 9.02 BGLAP F2 GGCX PROS1 VKORC1

Molecular functions related to Vitamin K Deficiency Hemorrhagic Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.26 BGLAP F2 MGP PROS1
2 structural constituent of bone GO:0008147 8.62 BGLAP MGP

Sources for Vitamin K Deficiency Hemorrhagic Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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