Vitreous Detachment disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: VTR003 MIFTS: 41	Vitreous Detachment Categories: Eye diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Vitreous Detachment

MalaCards integrated aliases for Vitreous Detachment:

Name: Vitreous Detachment ¹² ⁴⁴ ¹⁵ ¹⁷ ⁷²

Posterior Vitreous Detachment ⁷²

Classifications:

MalaCards categories:
Anatomical: Eye diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:9726

MeSH ⁴⁴ D020255

NCIt ⁵⁰ C50807

SNOMED-CT ⁶⁸ 53772007

ICD10 ³³ H43.81

EFO ¹⁷ EFO_1001238

UMLS ⁷² C0042907 C0423361

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Summaries for Vitreous Detachment

MalaCards based summary : Vitreous Detachment, also known as posterior vitreous detachment, is related to macular retinal edema and macular holes, and has symptoms including eye manifestations An important gene associated with Vitreous Detachment is KCNMA1 (Potassium Calcium-Activated Channel Subfamily M Alpha 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Degradation of the extracellular matrix. The drugs Bevacizumab and Temazepam have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and cortex, and related phenotypes are cardiovascular system and growth/size/body region

Wikipedia : ⁷⁵ A posterior vitreous detachment (PVD) is a condition of the eye in which the vitreous membrane separates... more...

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Related Diseases for Vitreous Detachment

Diseases related to Vitreous Detachment via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 73)

#	Related Disease	Score	Top Affiliating Genes
1	macular retinal edema	30.6	VEGFA KCNMA1
2	macular holes	30.1	VEGFA LHFPL5 KCNMA1
3	endophthalmitis	29.8	VEGFA PLG
4	retinal vascular disease	29.6	VEGFA PLG
5	macular degeneration, age-related, 1	29.4	VEGFA PLG OPTC KCNMA1
6	retinal detachment	10.8
7	myopia	10.5
8	microvascular complications of diabetes 5	10.5
9	hydrops, lactic acidosis, and sideroblastic anemia	10.5
10	cataract	10.4
11	refractive error	10.4
12	diabetic macular edema	10.4
13	microvascular complications of diabetes 1	10.3
14	microvascular complications of diabetes 2	10.3
15	retinal vein occlusion	10.3
16	intraocular pressure quantitative trait locus	10.2
17	neuroretinitis	10.2
18	retinitis	10.2
19	retinal disease	10.2
20	exudative vitreoretinopathy 1	10.1
21	retinitis pigmentosa	10.1
22	open-angle glaucoma	10.1
23	peripheral retinal degeneration	10.1
24	uveitis	10.1
25	optic nerve disease	10.1
26	retinal degeneration	10.1
27	scotoma	10.1
28	nonarteritic anterior ischemic optic neuropathy	10.0
29	kuhnt-junius degeneration	10.0
30	vitreous syneresis	10.0
31	neovascular glaucoma	10.0
32	vascular disease	10.0
33	neuropathy	10.0
34	47,xyy	10.0
35	optic disc pit	10.0
36	vitreoretinopathy	10.0
37	diabetes mellitus, noninsulin-dependent	9.9
38	fibrosis of extraocular muscles, congenital, 1	9.9
39	glaucoma, primary open angle	9.9
40	systemic lupus erythematosus	9.9
41	retinoblastoma	9.9
42	vitreoretinopathy, neovascular inflammatory	9.9
43	retinoschisis 1, x-linked, juvenile	9.9
44	astigmatism	9.9
45	pars planitis	9.9
46	cytomegalovirus retinitis	9.9
47	isolated ectopia lentis	9.9
48	disseminated intravascular coagulation	9.9
49	retinal vasculitis	9.9
50	retinal lattice degeneration	9.9

Graphical network of the top 20 diseases related to Vitreous Detachment:

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Symptoms & Phenotypes for Vitreous Detachment

UMLS symptoms related to Vitreous Detachment:

eye manifestations

MGI Mouse Phenotypes related to Vitreous Detachment:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	9.73	FN1 KCNMA1 LAMA5 OPTC PLG VEGFA
2	growth/size/body region	MP:0005378	9.63	FN1 KCNMA1 LAMA5 PLG SLC44A2 VEGFA
3	hearing/vestibular/ear	MP:0005377	9.26	KCNMA1 LAMA5 LHFPL5 SLC44A2
4	nervous system	MP:0003631	9.17	FN1 KCNMA1 LAMA5 LHFPL5 PLG SLC44A2

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Drugs & Therapeutics for Vitreous Detachment

Drugs for Vitreous Detachment (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 43)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Bevacizumab

Approved, Investigational

Phase 4

216974-75-3

Temazepam

Approved, Investigational

Phase 4

846-50-4

5391

Dexamethasone

Approved, Investigational, Vet_approved

Phase 4

50-02-2

5743

Dexamethasone acetate

Approved, Investigational, Vet_approved

Phase 4

1177-87-3

Angiogenesis Inhibitors

Phase 4

Angiogenesis Modulating Agents

Phase 4

Antineoplastic Agents, Immunological

Phase 4

Neurotransmitter Agents

Phase 4

Tranquilizing Agents

Phase 4

Anti-Anxiety Agents

Phase 4

GABA Agents

Phase 4

Hypnotics and Sedatives

Phase 4

GABA Modulators

Phase 4

Central Nervous System Depressants

Phase 4

Psychotropic Drugs

Phase 4

Hormone Antagonists

Phase 4

Antiemetics

Phase 4

Anti-Inflammatory Agents

Phase 4

Gastrointestinal Agents

Phase 4

HIV Protease Inhibitors

Phase 4

glucocorticoids

Phase 4

Hormones

Phase 4

Peripheral Nervous System Agents

Phase 4

Antineoplastic Agents, Hormonal

Phase 4

protease inhibitors

Phase 4

BB 1101

Phase 4

Autonomic Agents

Phase 4

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 4

Ranibizumab

Approved

Phase 2

347396-82-1

459903

Fibrinolysin

Investigational

Phase 2

9004-09-5

Pharmaceutical Solutions

Phase 2

Fibrinolytic Agents

Phase 2

Plasminogen

Phase 1, Phase 2

Triamcinolone

Approved, Vet_approved

124-94-7

31307

Dipivefrin

Approved

52365-63-6

3105

tannic acid

Approved

1401-55-4

Benzocaine

Approved, Investigational

94-09-7, 1994-09-7

2337

Tetrahydrozoline

Proxymetacaine

triamcinolone acetonide

Triamcinolone diacetate

Triamcinolone hexacetonide

Tissue Plasminogen Activator

Interventional clinical trials:

(show all 42)

#	Name	Status	NCT ID	Phase	Drugs
1	Combined Therapy in ARMD - Retrospective Case Series	Completed	NCT00805649	Phase 4	dexamethasone;bevacizumab;triamcincolone
2	A Phase 3 Safety and Efficacy Study of Vitreosolve® for Four Ophthalmic Intravitreal Injections For Inducing Posterior Vitreous Detachment in Retinopathy Patients.	Unknown status	NCT00908778	Phase 3	Vitreosolve;Vitreosolve
3	Resolution of Vitreomacular Adhesion (VMA) Associated With Neovascular Age Related Macular Degeneration (AMD) With Intravitreal Microplasmin	Unknown status	NCT00996684	Phase 2	Microplasmin;Placebo control
4	An Open-label Assessment of Intravitreous Injections of Vitrase (Hyaluronidase for Injection) for Inducing Posterior Vitreous Detachment in Subjects With Moderate to Severe Non-proliferative Diabetic Retinopathy	Completed	NCT00198471	Phase 2	Vitrase
5	A Randomized, Sham-Injection Controlled, Double-Masked, Ascending-Dose, Dose-Range-Finding Trial of Microplasmin Intravitreal Injection for Non-Surgical Posterior Vitreous Detachment (PVD) Induction for Treatment of DME.	Completed	NCT00412451	Phase 2	ocriplasmin
6	A Randomized, Sham-Injection Controlled, Double-Masked, Ascending-Dose, Dose-Range-Finding Trial of Microplasmin Intravitreal Injection for Non-Surgical Posterior Vitreous Detachment (PVD) Induction for Treatment of Vitreomacular Traction (VMT).	Completed	NCT00435539	Phase 2	ocriplasmin;ocriplasmin;Sham Comparator
7	An Open Label, Single Centre Trial of Microplasmin Intravitreal Injection for Non-Surgical Treatment of Focal Vitreomacular Adhesion	Completed	NCT01055535	Phase 2	Microplasmin
8	Posterior Vitreous Detachment (PVD) Assessment During Dual RVO Lucentis Evaluations (PADDLE Study)	Completed	NCT00831350	Phase 2	Ranibizumab
9	A Multicenter, Randomized, Placebo-Controlled, Double-Masked, Parallel Group, Dose-Ranging Clinical Trial of Intravitreal Microplasmin in Patients Undergoing Surgical Vitrectomy: The MIVI III (Microplasmin For Vitreous Injection III) Trial	Completed	NCT00412958	Phase 2	Ocriplasmin 25µg;Ocriplasmin 75µg;Ocriplasmin 125µg;Placebo
10	Protocol PVD-202: A Phase 2, Randomized, Double-Masked, Placebo-Controlled Multicenter Clinical Trial Designed to Evaluate the Safety and Efficacy Study of Luminate® in Inducing PVD in Non-Proliferative Diabetic Retinopathy	Completed	NCT02435862	Phase 2	1.0mg Luminate®;2.0mg Luminate®;3.0mg Luminate®
11	A Phase 2, Randomised, Double Masked, Sham Controlled, Multicentre Study to Evaluate the Efficacy and Safety of Ocriplasmin in Inducing Total Posterior Vitreous Detachment (PVD) in Subjects With Non-proliferative Diabetic Retinopathy (NPDR)	Active, not recruiting	NCT02681809	Phase 2	ocriplasmin 0.0625mg;ocriplasmin 0.125mg;Sham injection
12	A Multicenter, Randomized, Double Masked, Placebo Controlled, Sequential Dose Response Study of Intravitreally Administered Plasmin for the Creation of a Posterior Vitreous Detachment (PVD)	Terminated	NCT00348439	Phase 2	Plasmin;Vehicle
13	An Open Label Sequential Dose Response Observational Study of Intravitreally Administered Plasmin for the Creation of a Posterior Vitreous Detachment (PVD)	Terminated	NCT00347646	Phase 1, Phase 2	Plasmin
14	Microplasmin Intravitreal Administration in Participants With Uveitic Macular Edema	Terminated	NCT01194674	Phase 1, Phase 2	Microplasmin
15	Partial Posterior Hyaloidectomy in Macular Surgery : A Modified Procedure of Vitrectomy to Prevent Retinal Break Related to Induction of a Posterior Vitreous Detachment	Completed	NCT01454466	Phase 1
16	A Phase 1, Randomized, Sham-Controlled, Double-Masked, Dose Escalation, Multi-Center Study to Assess the Safety and Tolerability of Intravitreal ONL1204 in Patients With Macula-off, Rhegmatogenous Retinal Detachment	Not yet recruiting	NCT03780972	Phase 1	ONL1204
17	Vitreopapillary Traction and Optic Disc Morphology in Healthy Subjects, Vitreomacular Traction Patients and Glaucoma Patients	Unknown status	NCT02290795
18	Intravitreal Injection of Bevacizumab and Gas for Diabetic Premacular Hemorrhage With Active Fibrovascular Proliferation	Unknown status	NCT00673296		Intravitreal Bevacizumab
19	Evaluation of the Effect of Vitreous Composition Determined by Ultrasound and Optical Coherence Tomography (OCT) on Ranibizumab Therapy	Completed	NCT01256632		Ranibizumab
20	A Prospective Randomized Controlled Trial Evaluating the Safety and Efficacy of YAG Vitreolysis Versus Sham for Symptomatic Weiss Ring Due to Posterior Vitreous Detachment	Completed	NCT02897583
21	Ultrastructure Analysis of Excised Internal Limiting Membrane in Eyes of Highly Myopia With Myopic Traction Maculopathy	Completed	NCT02528058
22	Randomized Trial of Laser Ablation for Highly Symptomatic Floaters	Completed	NCT01970267
23	Assessment of Retinal Layers and Visual Rehabilitation After Epiretinal Membrane Removal	Completed	NCT01474655
24	Evaluation of Blood-retinal Barrier Functional Alterations by Optical Coherence Tomography	Completed	NCT01220804
25	OCT Documents Vitreo-papillary Traction	Completed	NCT03460600
26	Vitrectomy Without Laser or Gas Tamponade for Optic Disc Pit Maculopathy	Completed	NCT01340703
27	High-frequency-ultrasound Annular Arrays for Small Animal and Ophthalmic Imaging	Completed	NCT00633854
28	Intravitreal Administration of Ranibizumab Combined With Intravitreous Injection of Expansile Gas and Induction of Posterior Vitreous Detachment in Treatment of Exudative AMD With Posterior VMA: a Pilot, Open Label, Comparative Study	Completed	NCT01291121
29	Phase 1 Study of Optical Coherence Tomography Images to Identify the Prevalence of Vitreomacular Adhesion and Associated Maculopathies	Completed	NCT02160340
30	Vitrectomy for Persistent Macular Edema in Branch Retinal Vein Occlusion	Completed	NCT00685490
31	High-frequency-ultrasound Annular Arrays for Ophthalmic Imaging	Completed	NCT01415037
32	Extent of Internal Limiting Membrane Removal and Its Impact on Outcomes of Macular Hole Surgery	Completed	NCT02010138
33	Outcomes of Vitrectomy in Pediatric Retinal Detachment With Proliferative Vitreoretinopathy	Completed	NCT03208205
34	Role of Intraoperative Dexamethasone Implant in Improving Outcome of Taut Posterior Hyaloid Removal in Diabetic Macular Edema	Completed	NCT01698788		Dexamethasone Drug delivery system (Ozurdex)
35	Comparison of a Spectral OCT/SLO With the Stratus OCT for Imaging Various Retinal Pathologies	Completed	NCT00408720
36	Influence of Posterior Vitreous Detachment on Retinal Detachment After Lens Surgery in Myopic Eyes	Recruiting	NCT03152747
37	YAG Laser Vitreolysis of Symptomatic Vitreal Floaters	Recruiting	NCT03970148
38	Comparing the Surgical Outcomes of Internal Limiting Membrane Peeling-reposition Versus Peeling in Idiopathic Macular Holes: A Randomized Controlled Trial	Active, not recruiting	NCT03020459		Brilliant Blue G
39	Vitreomacular Interface Abnormalities Indiabetic Retinopathy Using Ocular Coherence Tomography	Not yet recruiting	NCT03686436
40	Effect on the Vitreous of the Not Complicated Surgery of the Cataract to the Emmetropic Patient	Terminated	NCT02783209
41	Evaluation of the Role of Intravitreal Injection of TPA in Treatment of Refractory Diabetic Macular Edema	Terminated	NCT01141881		Tissue Plasminogen Activator,bevacizumab ,follow up
42	Intravitreal Injection of Expansile Sulfa Hexafluoride Gas for Symptomatic Vitreomacular Adhesion	Withdrawn	NCT02001701

Search NIH Clinical Center for Vitreous Detachment

Cochrane evidence based reviews: vitreous detachment

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Genetic Tests for Vitreous Detachment

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Anatomical Context for Vitreous Detachment

MalaCards organs/tissues related to Vitreous Detachment:

⁴¹

Eye, Retina, Cortex, Endothelial, Brain, Testes

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Publications for Vitreous Detachment

Articles related to Vitreous Detachment:

(show top 50) (show all 1253)

#	Title	Authors	PMID	Year
1	Role of posterior vitreous detachment induced by intravitreal tissue plasminogen activator in macular edema with central retinal vein occlusion. ⁹ ³⁸	Murakami T...Yoshimura N	18040240	2007
2	The effect of tissue plasminogen activator on premacular hemorrhage. ⁹ ³⁸	Chung J...Chang KY	11195747	2001
3	OBSERVATION OF VITREOUS FEATURES USING ENHANCED VITREOUS IMAGING OPTICAL COHERENCE TOMOGRAPHY IN HIGHLY MYOPIC RETINOSCHISIS. ³⁸	Song M...Sun X	29912094	2019
4	Perfluoro-n-octane-assisted mega Weiss-ring technique for posterior vitreous detachment induction in retinal detachment. ³⁸	Babu N...Ramasamy K	31436194	2019
5	Point-of-care ultrasound for the evaluation of non-traumatic visual disturbances in the emergency department: The VIGMO protocol. ³⁸	Gandhi K...Teismann N	31130372	2019
6	Cost-Effectiveness of Limited Vitrectomy for Vision-Degrading Myodesopsia. ³⁸	Rostami B...Sebag J	30849342	2019
7	Posterior vitreous detachment and incidence of delayed retinal breaks: a retrospective, 2-year study at an academic centre. ³⁸	Nassrallah G...Deschenes J	31358152	2019
8	Characterization of Epiretinal Proliferation in Full-Thickness Macular Holes and Effects on Surgical Outcomes. ³⁸	Lee Kim E...Yonekawa Y	31104985	2019
9	[Vitreomacular Interface Diseases: Vitreomacular Adhesion, Vitreomacular Traction, Epiretinal Membranes, and Macular Hole]. ³⁸	Jandeck C	31416094	2019
10	Observation of anterior chamber volume after cataract surgery with swept-source optical coherence tomography. ³⁸	Chen M...Zhu X	30182270	2019
11	CHANGES IN THE POSTERIOR VITREOUS AFTER CATARACT SURGERY ASSESSED BY SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY. ³⁸	Otsuka Y...Yoshimura N	28277441	2019
12	Evaluation of posterior vitreous detachment using ultrasonography and optical coherence tomography. ³⁸	Moon SY...Kim YK	31301107	2019
13	ALTERATIONS OF MACULAR BLOOD FLOW IN SUPERFICIAL AND DEEP CAPILLARY PLEXUSES IN THE FELLOW AND AFFECTED EYES OF PATIENTS WITH UNILATERAL IDIOPATHIC EPIRETINAL MEMBRANE. ³⁸	Coppe AM...Ripandelli G	31305504	2019
14	Effect of vitreomacular adhesion on the treatment outcomes in the STOP-Uveitis clinical trial for non-infectious uveitis. ³⁸	Hassan M...STOP-Uveitis Investigators	31325001	2019
15	Intrachoroidal cavitation in myopic eyes. ³⁸	Venkatesh R...Yadav NK	31300972	2019
16	Ultrasonographic characteristics of active ocular toxoplasmosis. ³⁸	Morais FB...Allemann N	31038555	2019
17	Examiner Position in Ocular Point-of-Care Ultrasound: A Proposed Technique. ³⁸	Khattab E...Beals T	31003818	2019
18	Symptoms related to posterior vitreous detachment and the risk of developing retinal tears: a systematic review. ³⁸	Gishti O...van Overdam K	30632695	2019
19	Using the Retrobulbar Spot Sign to Assist in Diagnosis and Management of Central Retinal Artery Occlusions. ³⁸	Smith AT...Ferre RM	31228289	2019
20	Posterior Vitreous Detachment and the Associated Risk of Retinal Toxicity with Intravitreal Melphalan Treatment for Retinoblastoma. ³⁸	Berry JL...Kim JW	31367584	2019
21	POSTERIOR FUNDUS HEMORRHAGES: Frequency and Associated Factors: The Beijing Eye Study. ³⁸	Zhou JQ...Jonas JB	29533284	2019
22	Vitreous Biopsy Under Air: Technique, Complications, and Volume Outcomes. ³⁸	Zhao M...Liu W	31233153	2019
23	Outcome and Predictors for 2-Year Visual Acuity in Eyes with Diabetic Macular Edema Treated with Ranibizumab. ³⁸	Eski Yucel O...Sullu Y	30896316	2019
24	Iatrogenic retinal breaks and postoperative retinal detachments in microincision vitrectomy surgery compared with conventional 20-gauge vitrectomy: a meta-analysis. ³⁸	Chen GH...Li WS	30560911	2019
25	STRICT POSTURING WITH OR WITHOUT BILATERAL PATCHING FOR POSTERIOR VITREOUS DETACHMENT-RELATED VITREOUS HEMORRHAGE. ³⁸	van Etten PG...van Meurs JC	31136460	2019
26	Ophthalmological emergencies. An epidemiological study: Are resources been used properly? ³⁸	Dominguez-Serrano FB...Rodriguez-de-la-Rua-Franch E	30837174	2019
27	Point-of-Care Ultrasonography in the Diagnosis of Retinal Detachment, Vitreous Hemorrhage, and Vitreous Detachment in the Emergency Department. ³⁸	Lahham S...Fox JC	30977855	2019
28	Long-term outcomes of patients with myopic traction maculopathy after phacoemulsification for incident cataract. ³⁸	Cai L...Lu Y	30952957	2019
29	RESOLUTION OF FOVEAL CYST AFTER THE RELEASE OF VITREOMACULAR ATTACHMENT IN EYE WITH MACULAR TELANGIECTASIA TYPE 2. ³⁸	Kimura M...Iida T	28248745	2019
30	Vitreomacular Traction and Outer Retinal Structural Changes ³⁸	Yildirim S...Baris M	31055898	2019
31	Sex-Related Differences in the Progression of Posterior Vitreous Detachment with Age. ³⁸	Hayashi K...Hirata A	31014700	2019
32	MULTILAYERED OPTIC DISK HEMORRHAGE IN ADULTS WITHOUT A POSTERIOR VITREOUS DETACHMENT. ³⁸	Chen X...Baumal CR	30932996	2019
33	Indocyanine Green-Assisted Internal Limiting Membrane Peeling to Induce Posterior Vitreous Detachment in the Cases With Strong Vitreoretinal Adhesion. ³⁸	Chen F...Xie ZG	30893274	2019
34	Lack of Major Ophthalmic Findings in Patients with Primary Familial Brain Calcification Linked to SLC20A2 and PDGFB. ³⁸	Borges-Medeiros RL...de Oliveira JRM	30607898	2019
35	[UNUSUAL VITREOUS DETACHMENT]. ³⁸	Vishnevskia-Dai VV...Zloto O	30779488	2019
36	Early posterior vitreous detachment is associated with LAMA5 dominant mutation. ³⁸	Napolitano F...Sampaolo S	30589377	2019
37	Efficacy of non-fovea-sparing ILM peeling for symptomatic myopic foveoschisis with and without macular hole. ³⁸	Al-Badawi AH...Mortada HA	29712637	2019
38	Pathogenesis and Management of Macular Hole: Review of Current Advances. ³⁸	Bikbova G...Mori K	31191994	2019
39	LONGITUDINAL CHANGES IN THE OPTIC NERVE HEAD AND RETINA OVER TIME IN VERY YOUNG CHILDREN WITH FAMILIAL EXUDATIVE VITREORETINOPATHY. ³⁸	Lee J...Toth CA	29190238	2019
40	Absence of Posterior Vitreous Detachment Is a Risk Factor of Severe Bleb-Related Endophthalmitis. ³⁸	Umazume K...Goto H	30755799	2019
41	Predominantly Superior Retinal Tears Detected by B-Scan Ultrasonography. ³⁸	Streho M...Giocanti-Auregan A	31308974	2019
42	RETINAL DETACHMENT ASSOCIATED WITH PERIPAPILLARY STAPHYLOMA IMAGED WITH SWEPT SOURCE OPTICAL COHERENCE TOMOGRAPHY. ³⁸	Kunita D...Hirakata A	28072615	2019
43	LINCOFF RULES ARE NOT FOLLOWED IN RETINAL DETACHMENT WITH POSTERIOR BREAKS AND ATTACHED CORTICAL VITREOUS. ³⁸	Azad SV...Azad R	30562236	2019
44	International multi-center study of iatrogenic retinal tears in pars plana vitrectomy. ³⁸	Saleh OA...Schaal S	31236359	2019
45	Fibrin Glue and Internal Limiting Membrane Abrasion for Optic Disc Pit Maculopathy. ³⁸	Almeida DRP...Mahajan VB	30566713	2018
46	Pars plana vitrectomy in management of giant retinal tear and retinal detachment following iris-fixated anterior chamber phakic intraocular lens implantation. ³⁸	Sen S...Kumar A	30580313	2018
47	The role of posterior vitreous detachment on the efficacy of anti-vascular endothelial growth factor intravitreal injection for treatment of neovascular age-related macular degeneration. ³⁸	Neudorfer M...Barak A	30451182	2018
48	Spectral-Domain Optical Coherence Tomography of the Vitreopapillary Interface in Acute Nonarteritic Anterior Ischemic Optic Neuropathy. ³⁸	Thompson AC...Gospe SM	30098345	2018
49	Full-thickness macular hole associated with congenital simple hamartoma of retinal pigment epithelium (CSHRPE). ³⁸	Stavrakas P...Tranos P	28828540	2018
50	ULTRASONOGRAPHIC FINDINGS IN THE VITREOUS OF PATIENTS WITH AGE-RELATED MACULAR DEGENERATION TREATED WITH INTRAVITREAL ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR INJECTIONS. ³⁸	Mato-Gondelle T...Pineiro A	28820850	2018

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Genes for Vitreous Detachment

Genes related to Vitreous Detachment (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	KCNMA1	Potassium Calcium-Activated Channel Subfamily M Alpha 1	Protein Coding	16.09	DISEASES inferred ¹⁵
2	OPTC	Opticin	Protein Coding	16.02	DISEASES inferred ¹⁵
3	PLG	Plasminogen	Protein Coding	15.99	DISEASES inferred ¹⁵
4	FN1	Fibronectin 1	Protein Coding	15.81	DISEASES inferred ¹⁵
5	LHFPL5	LHFPL Tetraspan Subfamily Member 5	Protein Coding	15.29	DISEASES inferred ¹⁵
6	SLC44A2	Solute Carrier Family 44 Member 2	Protein Coding	15.18	DISEASES inferred ¹⁵
7	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	15.14	DISEASES inferred ¹⁵
8	LAMA5	Laminin Subunit Alpha 5	Protein Coding	14.98	DISEASES inferred ¹⁵

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Variations for Vitreous Detachment

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Expression for Vitreous Detachment

Search GEO for disease gene expression data for Vitreous Detachment.

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Pathways for Vitreous Detachment

Pathways related to Vitreous Detachment according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Response to elevated platelet cytosolic Ca2+ ⁶⁶ Show member pathways Disinhibition of SNARE formation ⁶⁶ Hemostasis ⁶⁶ Platelet activation, signaling and aggregation ⁶⁶ Platelet degranulation ⁶⁶	12.84	VEGFA PLG KCNMA1 FN1
2	Degradation of the extracellular matrix ⁶⁶ Show member pathways Collagen degradation ⁶⁶ Extracellular matrix organization ⁶⁶	12.11	PLG OPTC LAMA5 FN1
3	Small cell lung cancer ³⁷	11.44	LAMA5 FN1
4	Cell adhesion_ECM remodeling ²²	11.22	PLG FN1
5	Interleukin-4 and 13 signaling ⁶⁶	11.19	VEGFA LAMA5 FN1
6	amb2 Integrin signaling ¹	11.09	PLG FN1
7	Integrins in angiogenesis ¹	11.03	VEGFA FN1
8	Inflammatory Response Pathway ¹	10.84	LAMA5 FN1
9	Syndecan-4-mediated signaling events ¹	10.75	PLG FN1
10	Cell adhesion_Plasmin signaling ²²	10.49	VEGFA PLG FN1

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GO Terms for Vitreous Detachment

Cellular components related to Vitreous Detachment according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.65	VEGFA PLG OPTC LAMA5 FN1
2	collagen-containing extracellular matrix	GO:0062023	9.33	PLG LAMA5 FN1
3	basement membrane	GO:0005604	9.32	LAMA5 FN1
4	extracellular matrix	GO:0031012	9.26	VEGFA OPTC LAMA5 FN1
5	platelet alpha granule lumen	GO:0031093	8.8	VEGFA PLG FN1

Biological processes related to Vitreous Detachment according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytokine-mediated signaling pathway	GO:0019221	9.54	VEGFA LAMA5 FN1
2	angiogenesis	GO:0001525	9.43	VEGFA LAMA5 FN1
3	substrate adhesion-dependent cell spreading	GO:0034446	9.32	LAMA5 FN1
4	branching morphogenesis of an epithelial tube	GO:0048754	9.16	VEGFA LAMA5
5	platelet degranulation	GO:0002576	9.13	VEGFA PLG FN1
6	interaction with symbiont	GO:0051702	8.62	PLG FN1

Molecular functions related to Vitreous Detachment according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	signaling receptor binding	GO:0005102	9.13	PLG LAMA5 FN1
2	extracellular matrix structural constituent	GO:0005201	8.8	OPTC LAMA5 FN1

Sources

Sources for Vitreous Detachment

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ TGDB

⁷¹ Tocris

⁷² UMLS

⁷³ UMLS via Orphanet

⁷⁴ UniProtKB/Swiss-Prot

⁷⁵ Wikipedia