MCID: VTR003
MIFTS: 41

Vitreous Detachment

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Vitreous Detachment

MalaCards integrated aliases for Vitreous Detachment:

Name: Vitreous Detachment 12 44 15 17 70
Posterior Vitreous Detachment 70

Classifications:



External Ids:

Disease Ontology 12 DOID:9726
MeSH 44 D020255
NCIt 50 C50807
SNOMED-CT 67 267747007
ICD10 32 H43.81
UMLS 70 C0042907 C0423361

Summaries for Vitreous Detachment

MalaCards based summary : Vitreous Detachment, also known as posterior vitreous detachment, is related to macular holes and retinal detachment, and has symptoms including eye manifestations An important gene associated with Vitreous Detachment is LAMA5 (Laminin Subunit Alpha 5), and among its related pathways/superpathways are Phospholipase-C Pathway and PI3K-Akt signaling pathway. The drugs Fentanyl and Midazolam have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and cortex, and related phenotypes are cardiovascular system and vision/eye

Wikipedia : 73 A posterior vitreous detachment (PVD) is a condition of the eye in which the vitreous membrane separates... more...

Related Diseases for Vitreous Detachment

Diseases related to Vitreous Detachment via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 93)
# Related Disease Score Top Affiliating Genes
1 macular holes 31.1 VEGFA PLG OPTC FN1
2 retinal detachment 31.0 VEGFA GFAP COL2A1
3 microvascular complications of diabetes 5 30.8 VEGFA PLG PGF
4 myopia 30.6 VEGFA OPTC LAMA5 COL2A1
5 macular retinal edema 30.4 VEGFB VEGFA PGF
6 branch retinal artery occlusion 30.2 VEGFA PLG
7 central retinal artery occlusion 30.2 VEGFA PLG
8 vitreous syneresis 30.2 OPTC CYLC1 COL2A1
9 glaucoma, primary open angle 30.1 VEGFA OPTC FN1
10 preretinal fibrosis 29.9 VEGFA GFAP FN1
11 vitreoretinopathy, neovascular inflammatory 29.9 VEGFA GFAP FN1
12 kuhnt-junius degeneration 29.8 VEGFB VEGFA PLG PGF
13 retinal lattice degeneration 29.7 GFAP CYLC1 COL2A1
14 exudative vitreoretinopathy 1 29.7 VEGFB VEGFA PGF
15 microvascular complications of diabetes 1 29.5 VEGFB VEGFA PGF GFAP FN1
16 neovascular glaucoma 29.5 VEGFB VEGFA PLG PGF
17 endophthalmitis 29.5 VEGFB VEGFA PLG PGF
18 retinal vascular disease 29.4 VEGFB VEGFA PLG PGF FN1
19 macular degeneration, age-related, 1 29.3 VEGFB VEGFA PLG PGF OPTC GFAP
20 retinal artery occlusion 29.2 VEGFB VEGFA PLG PGF
21 cataract 10.4
22 diabetic macular edema 10.4
23 refractive error 10.4
24 microvascular complications of diabetes 2 10.3
25 rubeosis iridis 10.3 VEGFA PLG
26 erysipeloid 10.3 PLG FN1
27 choroid cancer 10.3 VEGFA CYLC1
28 retinal vein occlusion 10.3
29 perforated corneal ulcer 10.2 PLG FN1
30 intraocular pressure quantitative trait locus 10.2
31 retinal disease 10.2
32 spondylometaphyseal dysplasia, corner fracture type 10.2 FN1 COL2A1
33 neuroretinitis 10.2
34 retinitis 10.2
35 scotoma 10.2
36 synovial chondromatosis 10.2 FN1 COL2A1
37 decubitus ulcer 10.2 VEGFA FN1
38 spondyloepimetaphyseal dysplasia, strudwick type 10.1 FN1 COL2A1
39 cancer-associated retinopathy 10.1 VEGFA PGF
40 hypertensive encephalopathy 10.1 VEGFA PGF
41 epithelioid hemangioendothelioma 10.1 VEGFA PGF
42 retinitis pigmentosa 10.1
43 open-angle glaucoma 10.1
44 peripheral retinal degeneration 10.1
45 uveitis 10.1
46 optic nerve disease 10.1
47 retinal degeneration 10.1
48 diabetes mellitus 10.1
49 severe nonproliferative diabetic retinopathy 10.1 VEGFA PGF
50 glaucomatocyclitic crisis 10.1 SSC5D IGFBPL1 GPR162

Graphical network of the top 20 diseases related to Vitreous Detachment:



Diseases related to Vitreous Detachment

Symptoms & Phenotypes for Vitreous Detachment

UMLS symptoms related to Vitreous Detachment:


eye manifestations

MGI Mouse Phenotypes related to Vitreous Detachment:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.61 COL2A1 FN1 GFAP LAMA5 OPTC PGF
2 vision/eye MP:0005391 9.28 COL2A1 GFAP LAMA5 OPTC PDE6G PGF

Drugs & Therapeutics for Vitreous Detachment

Drugs for Vitreous Detachment (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
2
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
3
Triazolam Approved, Investigational Phase 4 28911-01-5 5556
4
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
5
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
6
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
7 Proxymetacaine Phase 4
8 Anesthetics Phase 4
9 Hypnotics and Sedatives Phase 4
10
Ranibizumab Approved Phase 2 347396-82-1 459903
11
Fibrinolysin Investigational Phase 2 9004-09-5
12 Angiogenesis Inhibitors Phase 2
13 Plasminogen Phase 2
14 Pharmaceutical Solutions Phase 2
15 Fibrinolytic Agents Phase 2
16
Dipivefrin Approved 52365-63-6 3105
17
Triamcinolone Approved, Vet_approved 124-94-7 31307
18
Bevacizumab Approved, Investigational 216974-75-3
19 Triamcinolone hexacetonide
20 Triamcinolone diacetate
21 triamcinolone acetonide
22 Antineoplastic Agents, Immunological
23 Tissue Plasminogen Activator

Interventional clinical trials:

(show all 28)
# Name Status NCT ID Phase Drugs
1 Comparative Analysis of Oral Sedation Versus Standard Intravenous Sedation in Vitreoretinal Surgery With Topical Anesthesia and Sub-tenon's Block Not yet recruiting NCT04346095 Phase 4 Oral Sedatives with or Without Analgesia;Intravenous Sedatives with or Without Analgesia
2 A Phase 3 Safety and Efficacy Study of Vitreosolve® for Four Ophthalmic Intravitreal Injections For Inducing Posterior Vitreous Detachment in Retinopathy Patients. Unknown status NCT00908778 Phase 3 Vitreosolve;Vitreosolve
3 An Open-label Assessment of Intravitreous Injections of Vitrase (Hyaluronidase for Injection) for Inducing Posterior Vitreous Detachment in Subjects With Moderate to Severe Non-proliferative Diabetic Retinopathy Completed NCT00198471 Phase 2 Vitrase
4 Posterior Vitreous Detachment (PVD) Assessment During Dual RVO Lucentis Evaluations (PADDLE Study) Completed NCT00831350 Phase 2 Ranibizumab
5 A Randomized, Sham-Injection Controlled, Double-Masked, Ascending-Dose, Dose-Range-Finding Trial of Microplasmin Intravitreal Injection for Non-Surgical Posterior Vitreous Detachment (PVD) Induction for Treatment of DME. Completed NCT00412451 Phase 2 ocriplasmin
6 A Randomized, Sham-Injection Controlled, Double-Masked, Ascending-Dose, Dose-Range-Finding Trial of Microplasmin Intravitreal Injection for Non-Surgical Posterior Vitreous Detachment (PVD) Induction for Treatment of Vitreomacular Traction (VMT). Completed NCT00435539 Phase 2 ocriplasmin;ocriplasmin;Sham Comparator
7 A Phase 2, Randomised, Double Masked, Sham Controlled, Multicentre Study to Evaluate the Efficacy and Safety of Ocriplasmin in Inducing Total Posterior Vitreous Detachment (PVD) in Subjects With Non-proliferative Diabetic Retinopathy (NPDR) Terminated NCT02681809 Phase 2 ocriplasmin 0.0625mg;ocriplasmin 0.125mg;Sham injection
8 An Open Label Sequential Dose Response Observational Study of Intravitreally Administered Plasmin for the Creation of a Posterior Vitreous Detachment (PVD) Terminated NCT00347646 Phase 1, Phase 2 Plasmin
9 A Multicenter, Randomized, Double Masked, Placebo Controlled, Sequential Dose Response Study of Intravitreally Administered Plasmin for the Creation of a Posterior Vitreous Detachment (PVD) Terminated NCT00348439 Phase 2 Plasmin;Vehicle
10 Partial Posterior Hyaloidectomy in Macular Surgery : A Modified Procedure of Vitrectomy to Prevent Retinal Break Related to Induction of a Posterior Vitreous Detachment Completed NCT01454466 Phase 1
11 Vitreopapillary Traction and Optic Disc Morphology in Healthy Subjects, Vitreomacular Traction Patients and Glaucoma Patients Unknown status NCT02290795
12 Vitrectomy Without Laser or Gas Tamponade for Optic Disc Pit Maculopathy Completed NCT01340703
13 Assessment of Retinal Layers and Visual Rehabilitation After Epiretinal Membrane Removal Completed NCT01474655
14 High-frequency-ultrasound Annular Arrays for Ophthalmic Imaging Completed NCT01415037
15 High-frequency-ultrasound Annular Arrays for Small Animal and Ophthalmic Imaging Completed NCT00633854
16 Randomized Trial of Laser Ablation for Highly Symptomatic Floaters Completed NCT01970267
17 Intravitreal Administration of Ranibizumab Combined With Intravitreous Injection of Expansile Gas and Induction of Posterior Vitreous Detachment in Treatment of Exudative AMD With Posterior VMA: a Pilot, Open Label, Comparative Study Completed NCT01291121
18 A Prospective Randomized Controlled Trial Evaluating the Safety and Efficacy of YAG Vitreolysis Versus Sham for Symptomatic Weiss Ring Due to Posterior Vitreous Detachment Completed NCT02897583
19 Vitrectomy for Persistent Macular Edema in Branch Retinal Vein Occlusion Completed NCT00685490
20 Outcomes of Vitrectomy in Pediatric Retinal Detachment With Proliferative Vitreoretinopathy Completed NCT03208205
21 Comparison of a Spectral OCT/SLO With the Stratus OCT for Imaging Various Retinal Pathologies Completed NCT00408720
22 Rate of Visual Field Progression Before and After Posterior Vitreous Detachment Recruiting NCT04719871
23 Influence of Posterior Vitreous Detachment on Retinal Detachment After Lens Surgery in Myopic Eyes Recruiting NCT03152747
24 YAG Laser Vitreolysis of Symptomatic Vitreal Floaters Recruiting NCT03970148
25 The Incidence of Complete Posterior Vitreous Degeneration After Phacoemulsification Not yet recruiting NCT04727398
26 Incidence of Complete Posterior Vitreous Detachment After Trabeculectomy. Not yet recruiting NCT04726267
27 Evaluation of the Role of Intravitreal Injection of TPA in Treatment of Refractory Diabetic Macular Edema Terminated NCT01141881 Tissue Plasminogen Activator,bevacizumab ,follow up
28 Effect on the Vitreous of the Not Complicated Surgery of the Cataract to the Emmetropic Patient Terminated NCT02783209

Search NIH Clinical Center for Vitreous Detachment

Cochrane evidence based reviews: vitreous detachment

Genetic Tests for Vitreous Detachment

Anatomical Context for Vitreous Detachment

MalaCards organs/tissues related to Vitreous Detachment:

40
Eye, Retina, Cortex, Endothelial, Bone

Publications for Vitreous Detachment

Articles related to Vitreous Detachment:

(show top 50) (show all 1356)
# Title Authors PMID Year
1
Role of posterior vitreous detachment induced by intravitreal tissue plasminogen activator in macular edema with central retinal vein occlusion. 54 61
18040240 2007
2
The effect of tissue plasminogen activator on premacular hemorrhage. 54 61
11195747 2001
3
Incidence of posterior vitreous detachment after congenital cataract surgery: an ultrasound evaluation. 61
33180157 2021
4
[Tomographic appearance and etiologies of epimacular membranes in Cotonou]. 61
33612325 2021
5
Characteristics and surgical outcomes of rhegmatogenous retinal detachments that develop after intravitreal injections. 61
33745092 2021
6
Point of care ultrasound and ocular injuries: A case of lens dislocation and a comprehensive review of the literature. 61
32783263 2021
7
A New Retinal Detachment Treatment Model for Evaluation of Vitreous Tamponades. 61
32806983 2021
8
Risk Factors for Onset or Progression of Posterior Vitreous Detachment at the Vitreomacular Interface after Cataract Surgery. 61
32688082 2021
9
Adverse events of repetitive transcranial magnetic stimulation in older adults with depression, a systematic review of the literature. 61
33156540 2021
10
Identification and Characterization of Epivascular Glia using En Face OCT. 61
33773982 2021
11
B-scan ultrasonography of vitreous dynamics during intravitreal administration of antiangiogenics. 61
33782363 2021
12
Refractive Errors, Ocular Biometry and Diabetic Retinopathy: A Comprehensive Review. 61
32589053 2021
13
The effects of aging on the mechanical properties of the vitreous. 61
33721627 2021
14
Prevalence of epiretinal membrane in the phakic eyes based on spectral-domain optical coherence tomography. 61
33411853 2021
15
Micro-incision vitrectomy surgery for primary rhegmatogenous retinal detachments with posterior vitreous detachments in elderly patients: Preoperative characteristics and surgical outcomes. 61
33406140 2021
16
Retinitis pigmentosa sine pigmento masqueraded as myopia: A case report (CARE). 61
33545995 2021
17
Intraoperative optical coherence tomography-assisted displacement of prepapillary membrane in eyes with optic disc pit maculopathy. 61
33459851 2021
18
The characteristics of optic disc pit maculopathy and the efficacy of vitrectomy: a systematic review and meta-analysis. 61
33421324 2021
19
Factors Determining the Morphology of Peripapillary Retinoschisis. 61
33790537 2021
20
Structural Retinal Assessment Using Optical Coherence Tomography and Fundus Fluorescein Angiography in Systemic Lupus Erythematosus Patients. 61
31688343 2021
21
Swept Source Optical Coherence Tomography Compared to Ultrasound and Biomicroscopy for Diagnosis of Posterior Vitreous Detachment. 61
33603328 2021
22
Intraoperative iatrogenic retinal breaks in 23-gauge vitrectomy for stage 3 and stage 4 idiopathic macular holes. 61
32217539 2021
23
Full-Thickness Macular Hole Secondary To Live Intraocular Filarial Worm: A Novel Clinical Association. 61
33492071 2021
24
Spontaneous macular hole closure after posterior vitreous detachment in an eye with hyperreflective OCT stress line. 61
33195877 2020
25
[Retinal Detachment Part 1 - Epidemiology, Risk Factors, Clinical Characteristics, Diagnostic Approach]. 61
33207382 2020
26
A mechanical model of posterior vitreous detachment and generation of vitreoretinal tractions. 61
32642790 2020
27
Spontaneous Vitreous Hemorrhage in a Naval Aviator. 61
33334413 2020
28
Prevalence of vitreous cortex remnants in eyes with primary rhegmatogenous retinal detachment undergoing vitrectomy. 61
33620992 2020
29
Standard 6-mm Compared with Widefield 16.5-mm OCT for Staging of Posterior Vitreous Detachment. 61
32442535 2020
30
Foveal crack sign as a predictive biomarker for development of macular hole in fellow eyes of patients with full-thickness macular holes. 61
33199791 2020
31
Vitreous and Vision Degrading Myodesopsia. 61
32151758 2020
32
Full thickness macular hole formation and spontaneous closure during intravitreal Ranibizumab therapy for central retinal vein occlusion. 61
33165304 2020
33
COMPARING INTRAVITREAL AIR AND GAS FOR THE TREATMENT OF VITREOMACULAR TRACTION. 61
31876891 2020
34
Effect of partial posterior vitreous detachment on spectral-domain optical coherence tomography retinal nerve fibre layer thickness measurements. 61
32051132 2020
35
OCT Assistance in Identifying Retinal Breaks in Symptomatic Posterior Vitreous Detachments. 61
33231695 2020
36
Continued smoking and posterior vitreous adhesion in the elderly evaluated on swept-source optical coherence tomography. 61
33116238 2020
37
Changing clinical patterns of Rhegmatogeneous Retinal Detachments during the COVID19 pandemic lockdown in the North West of the UK. 61
33073599 2020
38
A case of tractional retinal detachment associated with congenital retinal vascular hypoplasia in the superotemporal quadrant treated by vitreous surgery. 61
33028264 2020
39
Myopic macular hole detachment associated with intravitreal ocriplasmin. 61
32637726 2020
40
[Vitreous body hemorrhage-How long can one wait?] 61
32385553 2020
41
Vitreous Hemorrhage in Type 3 Gaucher Disease: An Angiographic and Pathologic Analysis. 61
33017378 2020
42
Outer Foveal Microdefects. 61
33007522 2020
43
Vitreous Structure and Visual Function in Myopic Vitreopathy Causing Vision-Degrading Myodesopsia. 61
32950508 2020
44
Removal of foveal hard exudates by subretinal balanced salt solution injection using 38-gauge needle in diabetic patients. 61
32451607 2020
45
Practice Patterns and Responsiveness to Simulated Common Ocular Complaints Among US Ophthalmology Centers During the COVID-19 Pandemic. 61
32777008 2020
46
ALTERATIONS OF MACULAR BLOOD FLOW IN SUPERFICIAL AND DEEP CAPILLARY PLEXUSES IN THE FELLOW AND AFFECTED EYES OF PATIENTS WITH UNILATERAL IDIOPATHIC EPIRETINAL MEMBRANE. 61
31305504 2020
47
Impact of posterior vitreous detachment on contrast sensitivity in patients with multifocal intraocular lens. 61
32318806 2020
48
On-Call Examinations for Acute Onset of Flashes, Floaters, or Curtain by Junior Ophthalmology Residents: Outcomes, Safety, and Resource Use. 61
32795660 2020
49
Effect of posterior vitreous detachment on treat-and-extend versus monthly ranibizumab for neovascular age-related macular degeneration. 61
31563866 2020
50
The effect of posterior vitreous detachment on aflibercept response in diabetic macular oedema. 61
32727727 2020

Variations for Vitreous Detachment

Expression for Vitreous Detachment

Search GEO for disease gene expression data for Vitreous Detachment.

Pathways for Vitreous Detachment

Pathways related to Vitreous Detachment according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.84 VEGFB PGF LAMA5 FN1 COL2A1
2
Show member pathways
12.57 VEGFB VEGFA PGF LAMA5 FN1 COL2A1
3 12.56 VEGFB VEGFA PGF LAMA5 FN1
4
Show member pathways
12.42 PLG OPTC LAMA5 FN1 COL2A1
5
Show member pathways
12.4 VEGFB VEGFA PGF LAMA5 FN1 COL2A1
6
Show member pathways
12.18 VEGFB VEGFA PGF FN1
7
Show member pathways
11.93 LAMA5 FN1 COL2A1
8 11.76 VEGFA LAMA5 FN1
9 11.67 VEGFB VEGFA FN1
10
Show member pathways
11.62 VEGFB VEGFA PGF
11 11.37 PLG FN1 COL2A1
12 11.19 VEGFA PLG FN1
13 10.86 FN1 COL2A1
14 10.41 VEGFB VEGFA
15 10.34 VEGFB PGF LAMA5 GFAP FN1 COL2A1
16
Show member pathways
10 VEGFB VEGFA PGF

GO Terms for Vitreous Detachment

Cellular components related to Vitreous Detachment according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.85 VEGFB VEGFA SSC5D PRSS3 PLG PGF
2 collagen-containing extracellular matrix GO:0062023 9.72 SSC5D PLG LAMA5 FN1 COL2A1
3 extracellular region GO:0005576 9.7 VEGFB VEGFA SSC5D PRSS3 PLG PGF
4 platelet alpha granule lumen GO:0031093 9.56 VEGFB VEGFA PLG FN1
5 basement membrane GO:0005604 9.54 LAMA5 FN1 COL2A1
6 extracellular matrix GO:0031012 9.1 VEGFA SSC5D OPTC LAMA5 FN1 COL2A1

Biological processes related to Vitreous Detachment according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.81 LAMA5 GFAP FN1 COL2A1
2 angiogenesis GO:0001525 9.8 VEGFB VEGFA PGF FN1
3 positive regulation of angiogenesis GO:0045766 9.71 VEGFB VEGFA PGF
4 positive regulation of endothelial cell proliferation GO:0001938 9.65 VEGFB VEGFA PGF
5 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.63 VEGFB VEGFA PGF
6 positive regulation of cell division GO:0051781 9.58 VEGFB VEGFA PGF
7 platelet degranulation GO:0002576 9.56 VEGFB VEGFA PLG FN1
8 branching morphogenesis of an epithelial tube GO:0048754 9.55 VEGFA LAMA5
9 positive chemotaxis GO:0050918 9.54 VEGFB VEGFA PGF
10 negative regulation of cell-cell adhesion mediated by cadherin GO:2000048 9.52 VEGFA PLG
11 sprouting angiogenesis GO:0002040 9.5 VEGFB VEGFA PGF
12 interaction with symbiont GO:0051702 9.43 PLG FN1
13 vascular endothelial growth factor signaling pathway GO:0038084 9.33 VEGFB VEGFA PGF
14 induction of positive chemotaxis GO:0050930 9.13 VEGFB VEGFA PGF
15 positive regulation of mast cell chemotaxis GO:0060754 8.8 VEGFB VEGFA PGF

Molecular functions related to Vitreous Detachment according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 9.62 VEGFB VEGFA PGF FN1
2 growth factor activity GO:0008083 9.61 VEGFB VEGFA PGF
3 integrin binding GO:0005178 9.58 LAMA5 GFAP FN1
4 proteoglycan binding GO:0043394 9.37 FN1 COL2A1
5 chemoattractant activity GO:0042056 9.33 VEGFB VEGFA PGF
6 vascular endothelial growth factor receptor 1 binding GO:0043183 9.26 VEGFB VEGFA
7 extracellular matrix structural constituent GO:0005201 9.26 OPTC LAMA5 FN1 COL2A1
8 vascular endothelial growth factor receptor binding GO:0005172 8.8 VEGFB VEGFA PGF

Sources for Vitreous Detachment

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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