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MCID: VTR003
MIFTS: 39

Vitreous Detachment

Categories: Neuronal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Vitreous Detachment

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MalaCards integrated aliases for Vitreous Detachment:

Name: Vitreous Detachment 12 43 15 17 71
Posterior Vitreous Detachment 71

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:9726
MeSH 43 D020255
NCIt 49 C50807
SNOMED-CT 67 53772007
ICD10 32 H43.81
UMLS 71 C0042907 C0423361
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Summaries for Vitreous Detachment

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MalaCards based summary : Vitreous Detachment, also known as posterior vitreous detachment, is related to macular retinal edema and branch retinal artery occlusion, and has symptoms including eye manifestations An important gene associated with Vitreous Detachment is LAMA5 (Laminin Subunit Alpha 5), and among its related pathways/superpathways are Phospholipase-C Pathway and PI3K-Akt signaling pathway. The drugs Bevacizumab and Temazepam have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and cortex.

Wikipedia : 74 A posterior vitreous detachment (PVD) is a condition of the eye in which the vitreous membrane separates... more...

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Related Diseases for Vitreous Detachment

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Diseases related to Vitreous Detachment via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 88)
# Related Disease Score Top Affiliating Genes
1 macular retinal edema 30.8 VEGFB VEGFA KCNMA1
2 branch retinal artery occlusion 30.3 VEGFA PLG
3 preretinal fibrosis 30.3 VEGFA FN1
4 central retinal artery occlusion 30.3 VEGFA PLG
5 myopia 30.1 VEGFA OPTC LAMA5 COL2A1
6 neovascular glaucoma 30.1 VEGFB VEGFA PLG
7 endophthalmitis 30.1 VEGFB VEGFA PLG
8 kuhnt-junius degeneration 30.0 VEGFB VEGFA PLG FAM187A
9 retinal vascular disease 30.0 VEGFB VEGFA PLG FN1
10 retinal artery occlusion 29.8 VEGFB VEGFA PLG
11 macular holes 29.7 VEGFA PLG OPTC LHFPL5 KCNMA1 FN1
12 vitreous syneresis 29.3 OPTC CYLC1 COL2A1
13 macular degeneration, age-related, 1 29.2 VEGFB VEGFA PLG OPTC LAMA3 KCNMA1
14 retinal lattice degeneration 28.9 DPT CYLC1 COL2A1
15 retinal detachment 10.8
16 joint laxity, short stature, and myopia 10.5
17 microvascular complications of diabetes 5 10.5
18 diabetic macular edema 10.4
19 cataract 10.4
20 refractive error 10.4
21 microvascular complications of diabetes 1 10.3
22 microvascular complications of diabetes 2 10.3
23 erysipeloid 10.3 PLG FN1
24 chorioretinal scar 10.3 VEGFA KCNMA1
25 retinal vein occlusion 10.3
26 intraocular pressure quantitative trait locus 10.2
27 retinal disease 10.2
28 neuroretinitis 10.2
29 retinitis 10.2
30 degenerative myopia 10.2 VEGFA DPT
31 glaucomatocyclitic crisis 10.2 SSC5D IGFBPL1
32 exudative vitreoretinopathy 1 10.1
33 retinitis pigmentosa 10.1
34 open-angle glaucoma 10.1
35 peripheral retinal degeneration 10.1
36 uveitis 10.1
37 optic nerve disease 10.1
38 retinal degeneration 10.1
39 scotoma 10.1
40 47,xyy 10.1
41 macular dystrophy, dominant cystoid 10.1 VEGFA KCNMA1
42 nonarteritic anterior ischemic optic neuropathy 10.0
43 vascular disease 10.0
44 neuropathy 10.0
45 optic disc pit 10.0
46 vitreoretinopathy 10.0
47 decubitus ulcer 10.0 VEGFA FN1
48 background diabetic retinopathy 10.0 VEGFB VEGFA
49 presbyopia 10.0 LAMA3 DPT
50 regular astigmatism 9.9 DPT CYLC1

Graphical network of the top 20 diseases related to Vitreous Detachment:



Diseases related to Vitreous Detachment
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Symptoms & Phenotypes for Vitreous Detachment

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UMLS symptoms related to Vitreous Detachment:


eye manifestations
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Drugs & Therapeutics for Vitreous Detachment

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Drugs for Vitreous Detachment (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 4 216974-75-3
2
Temazepam Approved, Investigational Phase 4 846-50-4 5391
3
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
4
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
5
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
6
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
7
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
8
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
9
Triazolam Approved, Investigational Phase 4 28911-01-5 5556
10
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
11 Angiogenesis Inhibitors Phase 4
12 Antineoplastic Agents, Immunological Phase 4
13 Neurotransmitter Agents Phase 4
14 Gastrointestinal Agents Phase 4
15 Hormones Phase 4
16 Antineoplastic Agents, Hormonal Phase 4
17 Anti-Anxiety Agents Phase 4
18 Psychotropic Drugs Phase 4
19 Hormone Antagonists Phase 4
20 Antiemetics Phase 4
21 GABA Modulators Phase 4
22 glucocorticoids Phase 4
23 Anti-Inflammatory Agents Phase 4
24 Proxymetacaine Phase 4
25 Hypnotics and Sedatives Phase 4
26 Anesthetics Phase 4
27
Ranibizumab Approved Phase 2 347396-82-1 459903
28
Fibrinolysin Investigational Phase 2 9004-09-5
29 Pharmaceutical Solutions Phase 2
30 Fibrinolytic Agents Phase 2
31 Plasminogen Phase 1, Phase 2
32
Dipivefrin Approved 52365-63-6 3105
33
Triamcinolone Approved, Vet_approved 124-94-7 31307
34
tannic acid Approved 1401-55-4
35
Benzocaine Approved, Investigational 94-09-7, 1994-09-7 2337
36 triamcinolone acetonide
37 Triamcinolone hexacetonide
38 Triamcinolone diacetate
39
protease inhibitors
40 HIV Protease Inhibitors
41 BB 1101
42 Tissue Plasminogen Activator

Interventional clinical trials:

(show all 42)
# Name Status NCT ID Phase Drugs
1 Combined Therapy in ARMD - Retrospective Case Series Completed NCT00805649 Phase 4 dexamethasone;bevacizumab;triamcincolone
2 Comparative Analysis of Oral Sedation Versus Standard Intravenous Sedation in Vitreoretinal Surgery With Topical Anesthesia and Sub-tenon's Block Not yet recruiting NCT04346095 Phase 4 Oral Sedatives with or Without Analgesia;Intravenous Sedatives with or Without Analgesia
3 A Phase 3 Safety and Efficacy Study of Vitreosolve® for Four Ophthalmic Intravitreal Injections For Inducing Posterior Vitreous Detachment in Retinopathy Patients. Unknown status NCT00908778 Phase 3 Vitreosolve;Vitreosolve
4 Resolution of Vitreomacular Adhesion (VMA) Associated With Neovascular Age Related Macular Degeneration (AMD) With Intravitreal Microplasmin Unknown status NCT00996684 Phase 2 Microplasmin;Placebo control
5 An Open-label Assessment of Intravitreous Injections of Vitrase (Hyaluronidase for Injection) for Inducing Posterior Vitreous Detachment in Subjects With Moderate to Severe Non-proliferative Diabetic Retinopathy Completed NCT00198471 Phase 2 Vitrase
6 A Phase 2, Randomised, Double Masked, Sham Controlled, Multicentre Study to Evaluate the Efficacy and Safety of Ocriplasmin in Inducing Total Posterior Vitreous Detachment (PVD) in Subjects With Non-proliferative Diabetic Retinopathy (NPDR) Completed NCT02681809 Phase 2 ocriplasmin 0.0625mg;ocriplasmin 0.125mg;Sham injection
7 A Randomized, Sham-Injection Controlled, Double-Masked, Ascending-Dose, Dose-Range-Finding Trial of Microplasmin Intravitreal Injection for Non-Surgical Posterior Vitreous Detachment (PVD) Induction for Treatment of DME. Completed NCT00412451 Phase 2 ocriplasmin
8 A Randomized, Sham-Injection Controlled, Double-Masked, Ascending-Dose, Dose-Range-Finding Trial of Microplasmin Intravitreal Injection for Non-Surgical Posterior Vitreous Detachment (PVD) Induction for Treatment of Vitreomacular Traction (VMT). Completed NCT00435539 Phase 2 ocriplasmin;ocriplasmin;Sham Comparator
9 An Open Label, Single Centre Trial of Microplasmin Intravitreal Injection for Non-Surgical Treatment of Focal Vitreomacular Adhesion Completed NCT01055535 Phase 2 Microplasmin
10 Posterior Vitreous Detachment (PVD) Assessment During Dual RVO Lucentis Evaluations (PADDLE Study) Completed NCT00831350 Phase 2 Ranibizumab
11 A Multicenter, Randomized, Double Masked, Placebo Controlled, Sequential Dose Response Study of Intravitreally Administered Plasmin for the Creation of a Posterior Vitreous Detachment (PVD) Terminated NCT00348439 Phase 2 Plasmin;Vehicle
12 An Open Label Sequential Dose Response Observational Study of Intravitreally Administered Plasmin for the Creation of a Posterior Vitreous Detachment (PVD) Terminated NCT00347646 Phase 1, Phase 2 Plasmin
13 Microplasmin Intravitreal Administration in Participants With Uveitic Macular Edema Terminated NCT01194674 Phase 1, Phase 2 Microplasmin
14 Partial Posterior Hyaloidectomy in Macular Surgery : A Modified Procedure of Vitrectomy to Prevent Retinal Break Related to Induction of a Posterior Vitreous Detachment Completed NCT01454466 Phase 1
15 A Phase 1 Open-Label, Dose Escalation Study to Assess the Safety and Tolerability of Intravitreal ONL1204 in Patients With Macula-off, Rhegmatogenous Retinal Detachment Recruiting NCT03780972 Phase 1 ONL1204
16 Vitreopapillary Traction and Optic Disc Morphology in Healthy Subjects, Vitreomacular Traction Patients and Glaucoma Patients Unknown status NCT02290795
17 Intravitreal Injection of Bevacizumab and Gas for Diabetic Premacular Hemorrhage With Active Fibrovascular Proliferation Unknown status NCT00673296 Intravitreal Bevacizumab
18 Evaluation of the Effect of Vitreous Composition Determined by Ultrasound and Optical Coherence Tomography (OCT) on Ranibizumab Therapy Completed NCT01256632 Ranibizumab
19 A Prospective Randomized Controlled Trial Evaluating the Safety and Efficacy of YAG Vitreolysis Versus Sham for Symptomatic Weiss Ring Due to Posterior Vitreous Detachment Completed NCT02897583
20 Ultrastructure Analysis of Excised Internal Limiting Membrane in Eyes of Highly Myopia With Myopic Traction Maculopathy Completed NCT02528058
21 Randomized Trial of Laser Ablation for Highly Symptomatic Floaters Completed NCT01970267
22 Assessment of Retinal Layers and Visual Rehabilitation After Epiretinal Membrane Removal Completed NCT01474655
23 OCT Documents Vitreo-papillary Traction Completed NCT03460600
24 Vitrectomy Without Laser or Gas Tamponade for Optic Disc Pit Maculopathy Completed NCT01340703
25 Evaluation of Blood-retinal Barrier Functional Alterations by Optical Coherence Tomography Completed NCT01220804
26 High-frequency-ultrasound Annular Arrays for Small Animal and Ophthalmic Imaging Completed NCT00633854
27 Intravitreal Administration of Ranibizumab Combined With Intravitreous Injection of Expansile Gas and Induction of Posterior Vitreous Detachment in Treatment of Exudative AMD With Posterior VMA: a Pilot, Open Label, Comparative Study Completed NCT01291121
28 Vitrectomy for Persistent Macular Edema in Branch Retinal Vein Occlusion Completed NCT00685490
29 Phase 1 Study of Optical Coherence Tomography Images to Identify the Prevalence of Vitreomacular Adhesion and Associated Maculopathies Completed NCT02160340
30 High-frequency-ultrasound Annular Arrays for Ophthalmic Imaging Completed NCT01415037
31 Outcomes of Vitrectomy in Pediatric Retinal Detachment With Proliferative Vitreoretinopathy Completed NCT03208205
32 Extent of Internal Limiting Membrane Removal and Its Impact on Outcomes of Macular Hole Surgery Completed NCT02010138
33 Perfluorocarbone Liquids for Tamponading Lower Retinal Breaks to Achieve Retinal Reattachment in Eyes of Retinal Detachment With Proliferative Vitreoretinopathy Completed NCT04168255
34 Comparing the Surgical Outcomes of Internal Limiting Membrane Peeling-reposition Versus Peeling in Idiopathic Macular Holes: A Randomized Controlled Trial Completed NCT03020459 Brilliant Blue G
35 Role of Intraoperative Dexamethasone Implant in Improving Outcome of Taut Posterior Hyaloid Removal in Diabetic Macular Edema Completed NCT01698788 Dexamethasone Drug delivery system (Ozurdex)
36 Comparison of a Spectral OCT/SLO With the Stratus OCT for Imaging Various Retinal Pathologies Completed NCT00408720
37 Influence of Posterior Vitreous Detachment on Retinal Detachment After Lens Surgery in Myopic Eyes Recruiting NCT03152747
38 YAG Laser Vitreolysis of Symptomatic Vitreal Floaters Recruiting NCT03970148
39 Vitreomacular Interface Abnormalities Indiabetic Retinopathy Using Ocular Coherence Tomography Not yet recruiting NCT03686436
40 Effect on the Vitreous of the Not Complicated Surgery of the Cataract to the Emmetropic Patient Terminated NCT02783209
41 Evaluation of the Role of Intravitreal Injection of TPA in Treatment of Refractory Diabetic Macular Edema Terminated NCT01141881 Tissue Plasminogen Activator,bevacizumab ,follow up
42 Intravitreal Injection of Expansile Sulfa Hexafluoride Gas for Symptomatic Vitreomacular Adhesion Withdrawn NCT02001701

Search NIH Clinical Center for Vitreous Detachment

Cochrane evidence based reviews: vitreous detachment

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Genetic Tests for Vitreous Detachment

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Anatomical Context for Vitreous Detachment

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MalaCards organs/tissues related to Vitreous Detachment:

40
Eye, Retina, Cortex, Endothelial, Brain, Testes
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Publications for Vitreous Detachment

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Articles related to Vitreous Detachment:

(show top 50) (show all 1312)
# Title Authors PMID Year
1
Role of posterior vitreous detachment induced by intravitreal tissue plasminogen activator in macular edema with central retinal vein occlusion. 54 61
18040240 2007
2
The effect of tissue plasminogen activator on premacular hemorrhage. 54 61
11195747 2001
3
Effect of posterior vitreous detachment on treat-and-extend versus monthly ranibizumab for neovascular age-related macular degeneration. 61
31563866 2020
4
Systematic ultrastructural comparison of swept-source and full-depth spectral domain optical coherence tomography imaging of diabetic macular oedema. 61
31473626 2020
5
STRICT POSTURING WITH OR WITHOUT BILATERAL PATCHING FOR POSTERIOR VITREOUS DETACHMENT-RELATED VITREOUS HEMORRHAGE. 61
31136460 2020
6
Anatomical and functional responses in eyes with diabetic macular edema treated with "1 + PRN" ranibizumab: one-year outcomes in population of mainland China. 61
32539744 2020
7
Induction of Posterior Vitreous Detachment in Pediatric Patients by Radial Perifoveal Stripping. 61
32541436 2020
8
Development of traumatic bilateral horseshoe-shaped macular tear without vitreous traction: Case report. 61
32317498 2020
9
Induction of posterior vitreous detachment (PVD) by non-enzymatic reagents targeting vitreous collagen liquefaction as well as vitreoretinal adhesion. 61
32427865 2020
10
Removal of foveal hard exudates by subretinal balanced salt solution injection using 38-gauge needle in diabetic patients. 61
32451607 2020
11
A novel hybrid approach for automated detection of retinal detachment using ultrasound images. 61
32250849 2020
12
[Rhegmatogenous retinal detachment in young adults: Clinical characteristics and surgical outcomes]. 61
32312595 2020
13
[Vitreous body hemorrhage-How long can one wait?] 61
32385553 2020
14
Standard 6 mm Compared to Wide Field 16.5 mm Optical Coherence Tomography for Staging of Posterior Vitreous Detachment. 61
32442535 2020
15
Retinal Features in Cynomolgus Macaques (Macaca fascicularis) Assessed by Using Scanning Laser Ophthalmoscopy and Spectral Domain Optical Coherence Tomography. 61
32164796 2020
16
Posterior Vitreous Detachment in Highly Myopic Patients. 61
32334432 2020
17
Comparison of Ocular Ultrasound Versus SD-OCT for Imaging of the Posterior Vitreous Status in Patients With DME. 61
32348535 2020
18
Vitreous albumin redox state in open-angle glaucoma patients and controls: a pilot study. 61
31925660 2020
19
Delayed Retinal Breaks and Detachments after Acute Posterior Vitreous Detachment. 61
31767432 2020
20
Impact of Posterior Vitreous Detachment on Treatment Outcomes in Diabetic Macular Edema. 61
31982388 2020
21
Impact of posterior vitreous detachment on contrast sensitivity in patients with multifocal intraocular lens. 61
32318806 2020
22
An Unusual Case: Self-separation of an Idiopathic Epiretinal Membrane 61
32167266 2020
23
Microsurgical observation of the posterior vitreous in patients with vitreous hemorrhage caused by Terson syndrome. 61
32083223 2020
24
Retinal tear and posterior vitreous detachment following repetitive transcranial magnetic stimulation for major depression: A case report. 61
31884185 2020
25
Vitreous and Vision Degrading Myodesopsia. 61
32151758 2020
26
Intraoperative iatrogenic retinal breaks in 23-gauge vitrectomy for stage 3 and stage 4 idiopathic macular holes. 61
32217539 2020
27
Posterior vitreous detachment in patients with diabetes mellitus. 61
32048080 2020
28
To Treat or Not to Treat: Management Options for Symptomatic Vitreous Floaters. 61
32097127 2020
29
Resolution of optic disc pit-associated macular retinoschisis after topical carbonic anhydrase inhibitor treatment: Report of a case. 61
32019335 2020
30
Ocular Point-of-Care Ultrasonography to Diagnose Posterior Chamber Abnormalities: A Systematic Review and Meta-analysis. 61
32074291 2020
31
Effect of partial posterior vitreous detachment on spectral-domain optical coherence tomography retinal nerve fibre layer thickness measurements. 61
32051132 2020
32
Evaluation of posterior vitreous detachment using ultrasonography and optical coherence tomography. 61
31301107 2020
33
Accuracy of Spectral-Domain OCT of the Macula for Detection of Complete Posterior Vitreous Detachment. 61
31864940 2020
34
Foveal cyst: Unknown etiology and unexplained response to treatment. 61
32054303 2020
35
Posterior Vitreous Detachment: Methods for Detection. 61
32033710 2020
36
Clinical Features of Vitreomacular Traction Syndrome with Peripheral Vitreoretinal Adhesion. 61
32095069 2020
37
FIRST-IN-HUMAN CLINICAL STUDY TO INVESTIGATE THE EFFECTIVENESS AND SAFETY OF PARS PLANA VITRECTOMY SURGERY USING A NEW HYPERSONIC TECHNOLOGY. 61
30358763 2020
38
Posterior Vitreous Detachment, Retinal Breaks, and Lattice Degeneration Preferred Practice Pattern®. 61
31757500 2020
39
Anterior vitreous detachment: risk factor for intraoperative complications during phacoemulsification. 61
32050233 2020
40
Posterior vitreous detachment and macular microvasculature in the elderly. 61
32267887 2020
41
Using the Retrobulbar Spot Sign to Assist in Diagnosis and Management of Central Retinal Artery Occlusions. 61
31228289 2020
42
[Preventive laser treatment of tractional symptomatic retinal flap tears: long-term outcomes]. 61
32504474 2020
43
Incidence and Risk Factors of Iatrogenic Retinal Breaks: 20-Gauge versus 25-Gauge Vitrectomy for Idiopathic Macular Hole Repair. 61
32104593 2020
44
RETINAL TEARS DUE TO PICKLEBALL INJURY. 61
31971926 2020
45
OUTCOME OF ACUTE NONTRAUMATIC VITREOUS HEMORRHAGE IN HEALTHY PATIENTS. 61
30300268 2020
46
NOVEL SURGICAL TECHNIQUE FOR INDUCING POSTERIOR VITREOUS DETACHMENT DURING PARS PLANA VITRECTOMY FOR PEDIATRIC PATIENTS USING A FLEXIBLE LOOP. 61
29176537 2020
47
Objective assessment of YAG laser vitreolysis in patients with symptomatic vitreous floaters. 61
31988795 2020
48
Intrachoroidal cavitation in myopic eyes. 61
31300972 2020
49
COMPARING INTRAVITREAL AIR AND GAS FOR THE TREATMENT OF VITREOMACULAR TRACTION. 61
31876891 2019
50
Swept-source optical coherence tomography features of regressed macular retinoblastoma. 61
31755441 2019
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Variations for Vitreous Detachment

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Expression for Vitreous Detachment

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Search GEO for disease gene expression data for Vitreous Detachment.
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Pathways for Vitreous Detachment

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Pathways related to Vitreous Detachment according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Phospholipase-C Pathway 63
Show member pathways
 12.87 VEGFB LAMA5 LAMA3 FN1 COL2A1
2
PI3K-Akt signaling pathway 36
Show member pathways
 12.68 VEGFB VEGFA LAMA5 LAMA3 FN1 COL2A1
3
Pathways in cancer 36
12.58 VEGFB VEGFA LAMA5 LAMA3 FN1
4
Focal Adhesion 36 1
Show member pathways
 12.5 VEGFB VEGFA LAMA5 LAMA3 FN1 COL2A1
5
Degradation of the extracellular matrix 65
Show member pathways
 12.09 PLG OPTC LAMA5 LAMA3 FN1 COL2A1
6
ECM-receptor interaction 36
Show member pathways
 11.82 LAMA5 LAMA3 FN1 COL2A1
7
Interleukin-4 and 13 signaling 65
11.78 VEGFA LAMA5 FN1
8
Amoebiasis 36
11.71 LAMA5 LAMA3 FN1
9
AGE-RAGE signaling pathway in diabetic complications 36
11.69 VEGFB VEGFA FN1
10
Small cell lung cancer 36
11.63 LAMA5 LAMA3 FN1
11
Cell adhesion_Plasmin signaling 22
11.27 VEGFA PLG FN1
12
Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway 1
10.89 FN1 COL2A1
13
Overview of nanoparticle effects 1
10.84 LAMA3 FN1
14
Syndecan-4-mediated signaling events 1
10.82 PLG LAMA3 FN1
15
G-protein signaling_Rap2B regulation pathway 22
10.78 VEGFB LAMA5 LAMA3 FN1 COL2A1
16
VEGF binds to VEGFR leading to receptor dimerization 65
Show member pathways
 10.74 VEGFB VEGFA
17
Cell adhesion_ECM remodeling 22
10.71 PLG LAMA3 FN1 COL2A1
18
miR-148a/miR-31/FIH1/HIF1andalpha;-Notch signaling in glioblastoma 1
10.39 VEGFB VEGFA
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GO Terms for Vitreous Detachment

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Cellular components related to Vitreous Detachment according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 10.02 VEGFB VEGFA SSC5D PLG LAMA5 IGFBPL1
2 extracellular region GO:0005576 9.9 VEGFB VEGFA SSC5D PLG OPTC LAMA5
3 basement membrane GO:0005604 9.62 LAMA5 LAMA3 FN1 COL2A1
4 platelet alpha granule lumen GO:0031093 9.56 VEGFB VEGFA PLG FN1
5 extracellular matrix GO:0031012 9.43 VEGFA SSC5D OPTC LAMA5 FN1 COL2A1
6 laminin-5 complex GO:0005610 9.4 LAMA5 LAMA3
7 collagen-containing extracellular matrix GO:0062023 9.17 SSC5D PLG LAMA5 LAMA3 FN1 DPT

Biological processes related to Vitreous Detachment according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.71 LAMA5 LAMA3 FN1 COL2A1
2 branching morphogenesis of an epithelial tube GO:0048754 9.49 VEGFA LAMA5
3 regulation of embryonic development GO:0045995 9.48 LAMA5 LAMA3
4 vascular endothelial growth factor signaling pathway GO:0038084 9.46 VEGFB VEGFA
5 induction of positive chemotaxis GO:0050930 9.43 VEGFB VEGFA
6 negative regulation of cell-cell adhesion mediated by cadherin GO:2000048 9.37 VEGFA PLG
7 morphogenesis of a polarized epithelium GO:0001738 9.32 LAMA5 LAMA3
8 positive regulation of mast cell chemotaxis GO:0060754 9.26 VEGFB VEGFA
9 interaction with symbiont GO:0051702 9.16 PLG FN1
10 collagen fibril organization GO:0030199 9.13 OPTC DPT COL2A1
11 platelet degranulation GO:0002576 8.92 VEGFB VEGFA PLG FN1

Molecular functions related to Vitreous Detachment according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.67 PLG LAMA5 LAMA3 FN1
2 integrin binding GO:0005178 9.5 LAMA5 LAMA3 FN1
3 fibronectin binding GO:0001968 9.4 VEGFA SSC5D
4 proteoglycan binding GO:0043394 9.26 FN1 COL2A1
5 vascular endothelial growth factor receptor binding GO:0005172 9.16 VEGFB VEGFA
6 extracellular matrix structural constituent GO:0005201 9.1 OPTC LAMA5 LAMA3 FN1 DPT COL2A1
7 vascular endothelial growth factor receptor 1 binding GO:0043183 8.96 VEGFB VEGFA
Sources

Sources for Vitreous Detachment

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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