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MCID: VTR003
MIFTS: 38

Vitreous Detachment

Categories: Eye diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Vitreous Detachment

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MalaCards integrated aliases for Vitreous Detachment:

Name: Vitreous Detachment 12 44 15 73
Posterior Vitreous Detachment 73

Classifications:

MalaCards categories:
Anatomical: Eye diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:9726
ICD10 33 H43.81
MeSH 44 D020255
NCIt 50 C50807
SNOMED-CT 68 53772007
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Summaries for Vitreous Detachment

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MalaCards based summary : Vitreous Detachment, also known as posterior vitreous detachment, is related to macular retinal edema and macular holes, and has symptoms including eye manifestations An important gene associated with Vitreous Detachment is KCNMA1 (Potassium Calcium-Activated Channel Subfamily M Alpha 1), and among its related pathways/superpathways are Degradation of the extracellular matrix and Microglia Activation During Neuroinflammation: Overview. The drugs Bevacizumab and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and endothelial, and related phenotype is digestive/alimentary.

Wikipedia : 76 A posterior vitreous detachment (PVD) is a condition of the eye in which the vitreous membrane separates... more...

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Related Diseases for Vitreous Detachment

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Diseases related to Vitreous Detachment via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
# Related Disease Score Top Affiliating Genes
1 macular retinal edema 30.6 KCNMA1 VEGFA
2 macular holes 30.1 KCNMA1 LHFPL5 VEGFA
3 macular degeneration, age-related, 1 30.0 KCNMA1 OPTC PLG VEGFA
4 endophthalmitis 29.8 PLG VEGFA
5 retinal detachment 10.5
6 microvascular complications of diabetes 5 10.3
7 diabetic macular edema 10.3
8 cataract 10.2
9 retinal vein occlusion 10.2
10 myopia 10.2
11 optic disk drusen 10.0 KCNMA1 VEGFA
12 chronic myocardial ischemia 10.0 PLG VEGFA
13 blood group, globoside system 10.0 PLG VEGFA
14 diabetes mellitus 10.0
15 kuhnt-junius degeneration 10.0
16 optic nerve disease 10.0
17 neuropathy 10.0
18 optic disc pit 10.0
19 retinal vascular occlusion 10.0 PLG VEGFA
20 vein disease 10.0 PLG VEGFA
21 corneal neovascularization 10.0 PLG VEGFA
22 retinal vascular disease 9.9 PLG VEGFA
23 arteries, anomalies of 9.9 PLG VEGFA
24 vitreous disease 9.9 OPTC PLG VEGFA
25 diabetes mellitus, noninsulin-dependent 9.9
26 exudative vitreoretinopathy 1 9.9
27 systemic lupus erythematosus 9.9
28 vitreoretinopathy, neovascular inflammatory 9.9
29 nonarteritic anterior ischemic optic neuropathy 9.9
30 retinitis pigmentosa 9.9
31 microvascular complications of diabetes 1 9.9
32 leber congenital amaurosis 4 9.9
33 pars planitis 9.9
34 microvascular complications of diabetes 2 9.9
35 ischemic optic neuropathy 9.9
36 isolated ectopia lentis 9.9
37 central retinal artery occlusion 9.9
38 central retinal vein occlusion 9.9
39 retinitis 9.9
40 retinal disease 9.9
41 retinal artery occlusion 9.9
42 lupus erythematosus 9.9
43 lens disease 9.8 LAMA3 VEGFA
44 nervous system disease 9.8 PLG VEGFA

Graphical network of the top 20 diseases related to Vitreous Detachment:



Diseases related to Vitreous Detachment
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Symptoms & Phenotypes for Vitreous Detachment

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UMLS symptoms related to Vitreous Detachment:


eye manifestations

MGI Mouse Phenotypes related to Vitreous Detachment:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 8.92 KCNMA1 LAMA3 PLG VEGFA
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Drugs & Therapeutics for Vitreous Detachment

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Drugs for Vitreous Detachment (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 46)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 4,Not Applicable 216974-75-3
2
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
3
Temazepam Approved, Investigational Phase 4 846-50-4 5391
4
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
5 Angiogenesis Inhibitors Phase 4,Phase 2,Phase 1,Not Applicable
6 Angiogenesis Modulating Agents Phase 4,Phase 2,Phase 1,Not Applicable
7 Pharmaceutical Solutions Phase 4,Phase 2
8 Hormones Phase 4,Phase 3
9 BB 1101 Phase 4
10 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3
11 Anti-Inflammatory Agents Phase 4,Phase 3
12 Psychotropic Drugs Phase 4
13 HIV Protease Inhibitors Phase 4
14 Antiemetics Phase 4
15 GABA Agents Phase 4
16 Central Nervous System Depressants Phase 4
17 Hypnotics and Sedatives Phase 4
18 Neurotransmitter Agents Phase 4
19 Anti-Anxiety Agents Phase 4
20
protease inhibitors Phase 4
21 Hormone Antagonists Phase 4,Phase 3
22 glucocorticoids Phase 4,Phase 3
23 GABA Modulators Phase 4
24 Peripheral Nervous System Agents Phase 4
25 Autonomic Agents Phase 4
26 Tranquilizing Agents Phase 4
27 Gastrointestinal Agents Phase 4
28 Antineoplastic Agents, Hormonal Phase 4
29
Triamcinolone Approved, Vet_approved Phase 3 124-94-7 31307
30 Fibrinolytic Agents Phase 3,Phase 2,Phase 1,Not Applicable
31 Plasminogen Phase 3,Phase 2,Phase 1,Not Applicable
32 triamcinolone acetonide Phase 3
33 Immunosuppressive Agents Phase 3
34 Triamcinolone hexacetonide Phase 3
35 Triamcinolone diacetate Phase 3
36 Immunologic Factors Phase 3,Phase 2,Phase 1,Not Applicable
37
Ranibizumab Approved Phase 2,Phase 1,Not Applicable 347396-82-1 459903
38
Fibrinolysin Investigational Phase 2,Phase 1 9004-09-5
39 Endothelial Growth Factors Phase 2
40 Ophthalmic Solutions Phase 2
41 Mitogens Phase 2
42
Dipivefrin Approved Not Applicable 52365-63-6 3105
43 Proxymetacaine
44 Diminazene aceturate Not Applicable
45 Tetrahydrozoline Not Applicable
46 Tissue Plasminogen Activator Not Applicable

Interventional clinical trials:

(show all 46)
# Name Status NCT ID Phase Drugs
1 Combined Therapy in Age-Related Macular Degeneration (ARMD) Completed NCT00805649 Phase 4 dexamethasone;bevacizumab;triamcincolone
2 Assessment of Patients Treated With JETREA® for Vitreomacular Traction Completed NCT02035748 Phase 4 Ocriplasmin
3 Ocriplasmin for Vitreomacular Traction/Symptomatic Vitreomacular Adhesion Completed NCT02322229 Phase 4 Ocriplasmin 0.125 mg in a 0.1 mL volume
4 A Safety and Efficacy Study of Vitreosolve® for Non-Proliferative Diabetic Retinopathy Subjects Unknown status NCT00908778 Phase 3 Vitreosolve;Vitreosolve
5 Trial of Microplasmin Intravitreal Injection for Non-surgical Treatment of Focal Vitreomacular Adhesion. The MIVI-TRUST (TG-MV-006) Trial. Completed NCT00781859 Phase 3 125 µg Ocriplasmin;Placebo
6 Trial of Microplasmin Intravitreal Injection for Non-Surgical Treatment of Focal Vitreomacular Adhesion. The MIVI-TRUST (TG-MV-007) Trial. Completed NCT00798317 Phase 3 Ocriplasmin 125µg;Placebo
7 Laser Versus Vitrectomy Versus Intravitreal Triamcinolone Injection for Diabetic Macular Edema Completed NCT00764244 Phase 3 Intravitreal triamcinolone injections
8 Combined Vitrectomy and Triamcinolone in Macular Edema Secondary to Branch Retinal Vein Occlusion (BRVO) Terminated NCT00642226 Phase 3
9 Assessment of Intravitreous Injections of Vitrase for Inducing Posterior Vitreous Detachment Completed NCT00198471 Phase 2 Vitrase
10 Posterior Vitreous Detachment (PVD) Assessment During Dual Retinal Vein Occlusion (RVO) Lucentis Evaluations Completed NCT00831350 Phase 2 Ranibizumab
11 A Study of the Safety and Efficacy of Microplasmin to Induce a Posterior Vitreous Detachment (MIVI III) Completed NCT00412958 Phase 2 Ocriplasmin 25µg;Ocriplasmin 75µg;Ocriplasmin 125µg;Placebo
12 A Study to Compare Multiple Doses Intravitreal Microplasmin for Treatment of Patients With Vitreomacular Traction (MIVI-IIt) Completed NCT00435539 Phase 2 ocriplasmin;ocriplasmin;Sham Comparator
13 A Multicenter Study to Compare Multiple Doses of Intravitreal Microplasmin Versus Sham Injection for Treatment of Patients With Diabetic Macular Edema (DME) Completed NCT00412451 Phase 2 ocriplasmin
14 A Clinical Trial Designed to Evaluate the Safety and Efficacy Study of Luminate® in Inducing PVD (Posterior Vitreous Detachment) in Non-Proliferative Diabetic Retinopathy Completed NCT02435862 Phase 2 1.0mg Luminate®;2.0mg Luminate®;3.0mg Luminate®
15 Clinical Trial of Intravitreal Microplasmin in Infants and Children Scheduled for Vitrectomy Completed NCT00986362 Phase 2 Ocriplasmin;Placebo
16 Intravitreal Microplasmin in Patients Undergoing Surgical Vitrectomy Completed NCT00123279 Phase 2 Microplasmin
17 Safety and Efficacy Study of Microplasmin in for Non-Surgical Treatment of Focal Vitreomacular Adhesion Completed NCT01055535 Phase 2 Microplasmin
18 An Extension to Study MD7108240 Completed NCT00733304 Phase 2 Pazopanib
19 A Study to Evaluate the Efficacy and Safety of Ocriplasmin in Inducing Total PVD in Subjects With NPDR Active, not recruiting NCT02681809 Phase 2 ocriplasmin 0.0625mg;ocriplasmin 0.125mg;Sham injection
20 A Study to Evaluate Plasmin for the Creation of a Posterior Vitreous Detachment (PVD) Terminated NCT00347646 Phase 1, Phase 2 Plasmin
21 Study to Evaluate Plasmin for the Creation of a Posterior Vitreous Detachment Terminated NCT00348439 Phase 2 Plasmin;Vehicle
22 Microplasmin Intravitreal Administration in Participants With Uveitic Macular Edema Terminated NCT01194674 Phase 1, Phase 2 Microplasmin
23 Partial Posterior Hyaloidectomy in Macular Surgery Completed NCT01454466 Phase 1
24 Ranibizumab in Hemorrhagic Choroidal Neovascularization Trial Completed NCT00363168 Phase 1 Ranibizumab;Ranibizumab
25 A Study to Evaluate the Safety and Tolerability of ONL1204 in Patients With Macula-off, Rhegmatogenous Retinal Detachment Not yet recruiting NCT03780972 Phase 1 ONL1204
26 Annular Array Ultrasound in Ophthalmology Unknown status NCT01415037
27 High-Frequency-Ultrasound Annular Arrays for Ophthalmic Imaging Unknown status NCT00633854
28 Vitreopapillary Interface and Optic Disc Morphology Unknown status NCT02290795
29 Intravitreal Injection of Bevacizumab and Gas for Diabetic Premacular Hemorrhage With Active Fibrovascular Proliferation Unknown status NCT00673296 Not Applicable Intravitreal Bevacizumab
30 Comparison of Two Techniques for Epiretinal or Internal Limiting Membrane Peel Unknown status NCT00892619 Not Applicable
31 Triple Therapy for Diffuse Diabetic Macular Edema Unknown status NCT01218750 Not Applicable
32 YAG Vitreolysis for Floaters Completed NCT02897583 Not Applicable
33 Intravitreal Ranibizumab in Exudative Age-related Macular Degeneration With Posterior Vitreomacular Adhesion Completed NCT01291121 Not Applicable
34 Clear Vision Study Completed NCT01970267 Not Applicable
35 Evaluation of the Effect of Vitreous Composition Determined by Ultrasound and Optical Coherence Tomography (OCT) on Ranibizumab Therapy Completed NCT01256632 Not Applicable Ranibizumab
36 Ultrastructure Analysis of Excised Internal Limiting Membrane in Eyes of Highly Myopia With Myopic Traction Maculopathy Completed NCT02528058
37 Comparison of a Spectral OCT/SLO With the Stratus OCT for Imaging Various Retinal Pathologies Completed NCT00408720
38 Prevalence of Vitreomacular Adhesion in Patients 40 Years and Older Completed NCT02160340
39 A Long-Term Safety Study of OZURDEX® in Clinical Practice Completed NCT01539577 dexamethasone 700 μg intravitreal implant
40 Outcomes of Vitrectomy in Pediatric Retinal Detachment With Proliferative Vitreoretinopathy Completed NCT03208205
41 Vitrectomy for Branch Retinal Vein Occlusion Completed NCT00685490
42 Retinal Layers and Visual Rehabilitation After Epiretinal Membrane Removal Completed NCT01474655 Not Applicable
43 Vitrectomy for Optic Disc Pit Maculopathy Completed NCT01340703 Not Applicable
44 Influence of Posterior Vitreous Detachment on Retinal Detachment After Lens Surgery in Myopic Eyes Recruiting NCT03152747
45 Effect on the Vitreous of the Not Complicated Surgery of the Cataract to the Emmetropic Patient Terminated NCT02783209 Not Applicable
46 Evaluation of the Role of Intravitreal Tissue Plasminogen Activator in Treatment of Refractory Diabetic Macular Edema Terminated NCT01141881 Not Applicable Tissue Plasminogen Activator,bevacizumab ,follow up

Search NIH Clinical Center for Vitreous Detachment

Cochrane evidence based reviews: vitreous detachment

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Genetic Tests for Vitreous Detachment

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Anatomical Context for Vitreous Detachment

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MalaCards organs/tissues related to Vitreous Detachment:

41
Eye, Retina, Endothelial, Cortex
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Publications for Vitreous Detachment

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Articles related to Vitreous Detachment:

(show top 50) (show all 269)
# Title Authors Year
1
Retinal detachment after acute posterior vitreous detachment resulting from posterior chamber phakic intraocular lens implantation. ( 29502596 )
2018
2
Can emergency physicians accurately distinguish retinal detachment from posterior vitreous detachment?: A response. ( 29793773 )
2018
3
Central retinal artery occlusion during vitrectomy: Immediate retinal revascularization following induction of posterior vitreous detachment. ( 29468216 )
2018
4
Posterior Vitreous Detachment as Observed by Wide-Angle OCT Imaging. ( 29631900 )
2018
5
Can emergency physicians accurately distinguish retinal detachment from posterior vitreous detachment with point-of-care ocular ultrasound? ( 29784278 )
2018
6
Bilateral Posterior Vitreous Detachment in a Young Patient with Systemic Lupus Erythematosus. ( 30057865 )
2018
7
Posterior Vitreous Detachment Precipitated by Yoga. ( 29581921 )
2018
8
FULL DIAGNOSTIC VITRECTOMY WITH POSTERIOR VITREOUS DETACHMENT INDUCTION FOR THE DIAGNOSIS OF VITRITIS DUE TO UNCERTAIN ETIOLOGY. ( 30005004 )
2018
9
Comment on "Ultrasound reliability in detection of retinal tear in acute symptomatic posterior vitreous detachment with vitreous hemorrhage". ( 30046548 )
2018
10
Posterior Vitreous Detachment. ( 30143091 )
2018
11
Post-Traumatic Giant Retinal Tear Without Posterior Vitreous Detachment: A Case Series. ( 30222803 )
2018
12
The vitreopapillary interface in healthy and glaucoma: posterior vitreous detachment in the vitreopapillary interface study. ( 30280516 )
2018
13
The role of posterior vitreous detachment on the efficacy of anti-vascular endothelial growth factor intravitreal injection for treatment of neovascular age-related macular degeneration. ( 30451182 )
2018
14
Ultrasound reliability in detection of retinal tear in acute symptomatic posterior vitreous detachment with vitreous hemorrhage. ( 29259914 )
2017
15
Myopia as a risk factor for subsequent retinal tears in the course of a symptomatic posterior vitreous detachment. ( 29191240 )
2017
16
Can emergency physicians accurately distinguish retinal detachment from posterior vitreous detachment with point-of-care ocular ultrasound? ( 29042095 )
2017
17
Cost-Utility of Evaluation for Posterior Vitreous Detachment and Prophylaxis of Retinal Detachment. ( 28732590 )
2017
18
Assessment of posterior vitreous detachment on enhanced high density line optical coherence tomography. ( 28149795 )
2017
19
Degradation of Contrast Sensitivity Function Following Posterior Vitreous Detachment. ( 28236439 )
2017
20
Response to Re: Evaluation of posterior vitreous detachment after uneventful phacoemulsification surgery by optical coherence tomography and ultrasonography. ( 28971519 )
2017
21
The Role of Posterior Vitreous Detachment and Vitreomacular Adhesion in Patients With Age-Related Macular Degeneration. ( 28297034 )
2017
22
Re: Evaluation of posterior vitreous detachment after uneventful phacoemulsification surgery by optical coherence tomography and ultrasonography. ( 28975671 )
2017
23
Posterior vitreous detachment - prevalence of and risk factors for retinal tears. ( 29075095 )
2017
24
Risk factors for multiple retinal tears in patients with acute posterior vitreous detachment. ( 28160191 )
2017
25
An unusual pathological posterior vitreous detachment. ( 28503754 )
2017
26
PARS PLANA VITRECTOMY AND LENSECTOMY FOR ECTOPIA LENTIS WITH AND WITHOUT THE INDUCTION OF A POSTERIOR VITREOUS DETACHMENT. ( 28207607 )
2017
27
Posterior Vitreous Detachment and the Posterior Hyaloid Membrane. ( 28867131 )
2017
28
PERIPAPILLARY RETINAL NERVE FIBER THICKNESS CHANGES AFTER VITRECTOMY FOR EPIRETINAL MEMBRANE IN EYES WITH AND WITHOUT VITREOUS DETACHMENT. ( 28098728 )
2017
29
NOVEL SURGICAL TECHNIQUE FOR INDUCING POSTERIOR VITREOUS DETACHMENT DURING PARS PLANA VITRECTOMY FOR PEDIATRIC PATIENTS USING A FLEXIBLE LOOP. ( 29176537 )
2017
30
Optic Nerve Head Hemorrhages Associated With Posterior Vitreous Detachment. ( 29063741 )
2017
31
Vitreous Hyper-Reflective Dots in Optical Coherence Tomography and Retinal Tear in Patients with Acute Posterior Vitreous Detachment. ( 28358220 )
2017
32
Incidence of Posterior Vitreous Detachment After Femtosecond LASIK Compared With Microkeratome LASIK. ( 28708815 )
2017
33
Posterior vitreous detachment and macular anatomical changes - a tomographic-electroretinographic study. ( 27833968 )
2016
34
Possible Relation between Lack of Posterior Vitreous Detachment and Severe Endogenous Endophthalmitis. ( 27766175 )
2016
35
Ranibizumab Versus Bevacizumab for Neovascular Age-Related Macular Degeneration With an Incomplete Posterior Vitreous Detachment. ( 26692256 )
2016
36
Prevalence of posterior vitreous detachment in glaucoma patients and controls. ( 27966831 )
2016
37
Posterior Vitreous Detachment Associated with Non-arteritic Ischaemic Optic Neuropathy. ( 27928412 )
2016
38
SCLERAL BUCKLE SURGERY FOR PRIMARY RETINAL DETACHMENT WITHOUT POSTERIOR VITREOUS DETACHMENT. ( 27172097 )
2016
39
Spectral domain optical coherence tomography and B-scan ultrasonography in the evaluation of retinal tears in acute, incomplete posterior vitreous detachment. ( 27215604 )
2016
40
Evaluation of posterior vitreous detachment after uneventful phacoemulsification surgery by optical coherence tomography and ultrasonography. ( 27435335 )
2016
41
Partial posterior vitreous detachment as a classification criterion of epiretinal membrane. ( 26929594 )
2016
42
Degradation of Contrast Sensitivity Function Following Posterior Vitreous Detachment. ( 27633841 )
2016
43
Induction of Posterior Vitreous Detachment in Pediatric Vitrectomy by Preoperative Intravitreal Injection of Tissue Plasminogen Activator. ( 27018884 )
2016
44
Relationship between variations in posterior vitreous detachment and visual prognosis in idiopathic epiretinal membranes. ( 26730176 )
2016
45
Surgical induction of posterior vitreous detachment using combined sharp dissection and active aspiration. ( 26833701 )
2016
46
POSTERIOR VITREOUS DETACHMENT IN HIGHLY MYOPIC EYES UNDERGOING VITRECTOMY. ( 26669837 )
2016
47
Spontaneous resolution of foveal detachment in traction maculopathy in high myopia unrelated to posterior vitreous detachment. ( 26868376 )
2016
48
Spontaneous resolution of optic disc pit maculopathy after posterior vitreous detachment. ( 26874168 )
2016
49
Spectral-Domain Optical Coherence Tomography in Acute Posterior Vitreous Detachment. ( 25935788 )
2015
50
Small-Gauge Pars Plana Vitrectomy for the Management of Symptomatic Posterior Vitreous Detachment after Phacoemulsification and Multifocal Intraocular Lens Implantation: A Pilot Study from the Pan-American Collaborative Retina Study Group. ( 26504590 )
2015
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Variations for Vitreous Detachment

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Expression for Vitreous Detachment

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Search GEO for disease gene expression data for Vitreous Detachment.
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Pathways for Vitreous Detachment

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Pathways related to Vitreous Detachment according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Degradation of the extracellular matrix 66
Show member pathways
 12.09 LAMA3 OPTC PLG
2
Microglia Activation During Neuroinflammation: Overview 65
Show member pathways
 11.42 LAMA3 PLG
3
Cell adhesion_ECM remodeling 22
10.94 LAMA3 PLG
4
Cell adhesion_Plasmin signaling 22
10.65 PLG VEGFA
5
Syndecan-4-mediated signaling events 1
10.11 LAMA3 PLG
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GO Terms for Vitreous Detachment

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Cellular components related to Vitreous Detachment according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet alpha granule lumen GO:0031093 8.62 PLG VEGFA

Biological processes related to Vitreous Detachment according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet degranulation GO:0002576 8.62 PLG VEGFA

Molecular functions related to Vitreous Detachment according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent GO:0005201 8.62 LAMA3 OPTC
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Sources for Vitreous Detachment

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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