Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect TGex
News and Views Disease Lists/Categories
About
About MalaCards Our Publications Academic Licensing Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MCID: VTR003
MIFTS: 37

Vitreous Detachment

Categories: Eye diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
Sources

Aliases & Classifications for Vitreous Detachment

About this section

MalaCards integrated aliases for Vitreous Detachment:

Name: Vitreous Detachment 12 44 15 73
Posterior Vitreous Detachment 73

Classifications:

MalaCards categories:
Anatomical: Eye diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:9726
ICD10 33 H43.81
MeSH 44 D020255
NCIt 50 C50807
Sources

Summaries for Vitreous Detachment

About this section
MalaCards based summary : Vitreous Detachment, also known as posterior vitreous detachment, is related to macular retinal edema and macular holes, and has symptoms including eye manifestations An important gene associated with Vitreous Detachment is KCNMA1 (Potassium Calcium-Activated Channel Subfamily M Alpha 1), and among its related pathways/superpathways are Degradation of the extracellular matrix and Cell adhesion_ECM remodeling. The drugs Bevacizumab and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and retina, and related phenotype is digestive/alimentary.

Sources

Related Diseases for Vitreous Detachment

About this section

Diseases related to Vitreous Detachment via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)
# Related Disease Score Top Affiliating Genes
1 macular retinal edema 29.9 KCNMA1 VEGFA
2 macular holes 29.4 KCNMA1 LHFPL5 VEGFA
3 endophthalmitis 29.2 PLG VEGFA
4 macular degeneration, age-related, 1 28.4 KCNMA1 OPTC PLG VEGFA
5 retinitis 10.6
6 retinal detachment 10.4
7 aging 10.2
8 microvascular complications of diabetes 5 10.2
9 diabetic macular edema 10.1
10 cataract 10.1
11 retinal vein occlusion 10.1
12 myopia 10.1
13 diabetes mellitus 9.9
14 optic nerve disease 9.9
15 neuropathy 9.9
16 endotheliitis 9.9
17 macular dystrophy, dominant cystoid 9.8 KCNMA1 VEGFA
18 exudative vitreoretinopathy 1 9.8
19 vitreoretinopathy, neovascular inflammatory 9.8
20 nonarteritic anterior ischemic optic neuropathy 9.8
21 retinitis pigmentosa 9.8
22 microvascular complications of diabetes 1 9.8
23 leber congenital amaurosis 4 9.8
24 microvascular complications of diabetes 2 9.8
25 ischemic optic neuropathy 9.8
26 isolated ectopia lentis 9.8
27 choroiditis 9.8
28 central retinal artery occlusion 9.8
29 central retinal vein occlusion 9.8
30 retinal disease 9.8
31 retinal artery occlusion 9.8
32 chronic myocardial ischemia 9.7 PLG VEGFA
33 blood group, globoside system 9.7 PLG VEGFA
34 retinal vascular occlusion 9.7 PLG VEGFA
35 rubeosis iridis 9.6 PLG VEGFA
36 degeneration of macula and posterior pole 9.6 PLG VEGFA
37 corneal neovascularization 9.4 PLG VEGFA
38 lens disease 9.4 LAMA3 VEGFA
39 retinal vascular disease 9.3 PLG VEGFA
40 vitreous disease 9.3 OPTC PLG VEGFA
41 arteries, anomalies of 9.1 PLG VEGFA

Graphical network of the top 20 diseases related to Vitreous Detachment:



Diseases related to Vitreous Detachment
Sources

Symptoms & Phenotypes for Vitreous Detachment

About this section

UMLS symptoms related to Vitreous Detachment:


eye manifestations

MGI Mouse Phenotypes related to Vitreous Detachment:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 8.92 KCNMA1 LAMA3 PLG VEGFA
Sources

Drugs & Therapeutics for Vitreous Detachment

About this section

Drugs for Vitreous Detachment (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 46)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 4,Not Applicable 216974-75-3
2
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
3
Temazepam Approved, Investigational Phase 4 846-50-4 5391
4 Angiogenesis Inhibitors Phase 4,Phase 2,Phase 1,Not Applicable
5 Angiogenesis Modulating Agents Phase 4,Phase 2,Phase 1,Not Applicable
6 Pharmaceutical Solutions Phase 4,Phase 2
7 Dexamethasone acetate Phase 4 1177-87-3
8 glucocorticoids Phase 4,Phase 3
9
protease inhibitors Phase 4
10 Central Nervous System Depressants Phase 4
11 GABA Agents Phase 4
12 GABA Modulators Phase 4
13 Gastrointestinal Agents Phase 4
14 Neurotransmitter Agents Phase 4
15 HIV Protease Inhibitors Phase 4
16 Hormone Antagonists Phase 4,Phase 3
17 Tranquilizing Agents Phase 4
18 Hormones Phase 4,Phase 3
19 Anti-Anxiety Agents Phase 4
20 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3
21 Peripheral Nervous System Agents Phase 4
22 Hypnotics and Sedatives Phase 4
23 Antiemetics Phase 4
24 Anti-Inflammatory Agents Phase 4,Phase 3
25 Psychotropic Drugs Phase 4
26 BB 1101 Phase 4
27 Autonomic Agents Phase 4
28 Antineoplastic Agents, Hormonal Phase 4
29
Triamcinolone Approved, Vet_approved Phase 3 124-94-7 31307
30 triamcinolone acetonide Phase 3
31 Fibrinolytic Agents Phase 3,Phase 2,Phase 1,Not Applicable
32 Triamcinolone diacetate Phase 3
33 Triamcinolone hexacetonide Phase 3
34 Plasminogen Phase 3,Phase 2,Phase 1,Not Applicable
35 Immunosuppressive Agents Phase 3
36
Ranibizumab Approved Phase 2,Phase 1,Not Applicable 347396-82-1 459903
37
Fibrinolysin Investigational Phase 2,Phase 1 9004-09-5
38 Mitogens Phase 2
39 Tetrahydrozoline Phase 2,Not Applicable
40 Ophthalmic Solutions Phase 2
41 Endothelial Growth Factors Phase 2
42
Menthol Approved Not Applicable 2216-51-5 16666
43
Dipivefrin Approved Not Applicable 52365-63-6 3105
44 Diminazene aceturate Not Applicable
45 Proxymetacaine
46 Tissue Plasminogen Activator Not Applicable

Interventional clinical trials:

(show all 45)
# Name Status NCT ID Phase Drugs
1 Combined Therapy in Age-Related Macular Degeneration (ARMD) Completed NCT00805649 Phase 4 dexamethasone;bevacizumab;triamcincolone
2 Assessment of Patients Treated With JETREA® for Vitreomacular Traction Completed NCT02035748 Phase 4 Ocriplasmin
3 A Safety and Efficacy Study of Vitreosolve® for Non-Proliferative Diabetic Retinopathy Subjects Unknown status NCT00908778 Phase 3 Vitreosolve;Vitreosolve
4 Trial of Microplasmin Intravitreal Injection for Non-surgical Treatment of Focal Vitreomacular Adhesion. The MIVI-TRUST (TG-MV-006) Trial. Completed NCT00781859 Phase 3 125 µg Ocriplasmin;Placebo
5 Trial of Microplasmin Intravitreal Injection for Non-Surgical Treatment of Focal Vitreomacular Adhesion. The MIVI-TRUST (TG-MV-007) Trial. Completed NCT00798317 Phase 3 Ocriplasmin 125µg;Placebo
6 Laser Versus Vitrectomy Versus Intravitreal Triamcinolone Injection for Diabetic Macular Edema Completed NCT00764244 Phase 3 Intravitreal triamcinolone injections
7 Combined Vitrectomy and Triamcinolone in Macular Edema Secondary to Branch Retinal Vein Occlusion (BRVO) Terminated NCT00642226 Phase 3
8 Assessment of Intravitreous Injections of Vitrase for Inducing Posterior Vitreous Detachment Completed NCT00198471 Phase 2 Vitrase
9 Posterior Vitreous Detachment (PVD) Assessment During Dual Retinal Vein Occlusion (RVO) Lucentis Evaluations Completed NCT00831350 Phase 2 Ranibizumab
10 A Study of the Safety and Efficacy of Microplasmin to Induce a Posterior Vitreous Detachment (MIVI III) Completed NCT00412958 Phase 2 Ocriplasmin 25µg;Ocriplasmin 75µg;Ocriplasmin 125µg;Placebo
11 A Study to Compare Multiple Doses Intravitreal Microplasmin for Treatment of Patients With Vitreomacular Traction (MIVI-IIt) Completed NCT00435539 Phase 2 ocriplasmin;ocriplasmin;Sham Comparator
12 A Multicenter Study to Compare Multiple Doses of Intravitreal Microplasmin Versus Sham Injection for Treatment of Patients With Diabetic Macular Edema (DME) Completed NCT00412451 Phase 2 ocriplasmin
13 A Clinical Trial Designed to Evaluate the Safety and Efficacy Study of Luminate® in Inducing PVD (Posterior Vitreous Detachment) in Non-Proliferative Diabetic Retinopathy Completed NCT02435862 Phase 2 1.0mg Luminate®;2.0mg Luminate®;3.0mg Luminate®
14 Clinical Trial of Intravitreal Microplasmin in Infants and Children Scheduled for Vitrectomy Completed NCT00986362 Phase 2 Ocriplasmin;Placebo
15 Intravitreal Microplasmin in Patients Undergoing Surgical Vitrectomy Completed NCT00123279 Phase 2 Microplasmin
16 Safety and Efficacy Study of Microplasmin in for Non-Surgical Treatment of Focal Vitreomacular Adhesion Completed NCT01055535 Phase 2 Microplasmin
17 An Extension to Study MD7108240 Completed NCT00733304 Phase 2 Pazopanib
18 A Study to Evaluate the Efficacy and Safety of Ocriplasmin in Inducing Total PVD in Subjects With NPDR Active, not recruiting NCT02681809 Phase 2 ocriplasmin 0.0625mg;ocriplasmin 0.125mg;Sham injection
19 A Study to Evaluate Plasmin for the Creation of a Posterior Vitreous Detachment (PVD) Terminated NCT00347646 Phase 1, Phase 2 Plasmin
20 Study to Evaluate Plasmin for the Creation of a Posterior Vitreous Detachment Terminated NCT00348439 Phase 2 Plasmin;Vehicle
21 Microplasmin Intravitreal Administration in Participants With Uveitic Macular Edema Terminated NCT01194674 Phase 1, Phase 2 Microplasmin
22 Partial Posterior Hyaloidectomy in Macular Surgery Completed NCT01454466 Phase 1
23 Ranibizumab in Hemorrhagic Choroidal Neovascularization Trial Completed NCT00363168 Phase 1 Ranibizumab;Ranibizumab
24 Annular Array Ultrasound in Ophthalmology Unknown status NCT01415037
25 Effect of Vitrectomy and Posterior Vitreous Detachment on Intravitreal Ranibizumab Pharmacokinetics Unknown status NCT02174211 Not Applicable Ranibizumab
26 High-Frequency-Ultrasound Annular Arrays for Ophthalmic Imaging Unknown status NCT00633854
27 Vitreopapillary Interface and Optic Disc Morphology Unknown status NCT02290795
28 Intravitreal Injection of Bevacizumab and Gas for Diabetic Premacular Hemorrhage With Active Fibrovascular Proliferation Unknown status NCT00673296 Not Applicable Intravitreal Bevacizumab
29 Comparison of Two Techniques for Epiretinal or Internal Limiting Membrane Peel Unknown status NCT00892619 Not Applicable
30 Triple Therapy for Diffuse Diabetic Macular Edema Unknown status NCT01218750 Not Applicable
31 YAG Vitreolysis for Floaters Completed NCT02897583 Not Applicable
32 Intravitreal Ranibizumab in Exudative Age-related Macular Degeneration With Posterior Vitreomacular Adhesion Completed NCT01291121 Not Applicable
33 Clear Vision Study Completed NCT01970267 Not Applicable
34 Evaluation of the Effect of Vitreous Composition Determined by Ultrasound and Optical Coherence Tomography (OCT) on Ranibizumab Therapy Completed NCT01256632 Not Applicable Ranibizumab
35 Ultrastructure Analysis of Excised Internal Limiting Membrane in Eyes of Highly Myopia With Myopic Traction Maculopathy Completed NCT02528058
36 Comparison of a Spectral OCT/SLO With the Stratus OCT for Imaging Various Retinal Pathologies Completed NCT00408720
37 Prevalence of Vitreomacular Adhesion in Patients 40 Years and Older Completed NCT02160340
38 A Long-Term Safety Study of OZURDEX® in Clinical Practice Completed NCT01539577 dexamethasone 700 μg intravitreal implant
39 Outcomes of Vitrectomy in Pediatric Retinal Detachment With Proliferative Vitreoretinopathy Completed NCT03208205
40 Vitrectomy for Branch Retinal Vein Occlusion Completed NCT00685490
41 Retinal Layers and Visual Rehabilitation After Epiretinal Membrane Removal Completed NCT01474655 Not Applicable
42 Vitrectomy for Optic Disc Pit Maculopathy Completed NCT01340703 Not Applicable
43 Influence of Posterior Vitreous Detachment on Retinal Detachment After Lens Surgery in Myopic Eyes Recruiting NCT03152747
44 Effect on the Vitreous of the Not Complicated Surgery of the Cataract to the Emmetropic Patient Terminated NCT02783209 Not Applicable
45 Evaluation of the Role of Intravitreal Tissue Plasminogen Activator in Treatment of Refractory Diabetic Macular Edema Terminated NCT01141881 Not Applicable Tissue Plasminogen Activator,bevacizumab ,follow up

Search NIH Clinical Center for Vitreous Detachment

Cochrane evidence based reviews: vitreous detachment

Sources

Genetic Tests for Vitreous Detachment

About this section
Sources

Anatomical Context for Vitreous Detachment

About this section

MalaCards organs/tissues related to Vitreous Detachment:

41
Eye, Endothelial, Retina, Cortex
Sources

Publications for Vitreous Detachment

About this section

Articles related to Vitreous Detachment:

(show top 50) (show all 259)
# Title Authors Year
1
Retinal detachment after acute posterior vitreous detachment resulting from posterior chamber phakic intraocular lens implantation. ( 29502596 )
2018
2
Can emergency physicians accurately distinguish retinal detachment from posterior vitreous detachment?: A response. ( 29793773 )
2018
3
Central retinal artery occlusion during vitrectomy: Immediate retinal revascularization following induction of posterior vitreous detachment. ( 29468216 )
2018
4
Posterior Vitreous Detachment as Observed by Wide-Angle OCT Imaging. ( 29631900 )
2018
5
Can emergency physicians accurately distinguish retinal detachment from posterior vitreous detachment with point-of-care ocular ultrasound? ( 29784278 )
2018
6
Posterior Vitreous Detachment Precipitated by Yoga. ( 29581921 )
2018
7
Ultrasound reliability in detection of retinal tear in acute symptomatic posterior vitreous detachment with vitreous hemorrhage. ( 29259914 )
2017
8
Myopia as a risk factor for subsequent retinal tears in the course of a symptomatic posterior vitreous detachment. ( 29191240 )
2017
9
Can emergency physicians accurately distinguish retinal detachment from posterior vitreous detachment with point-of-care ocular ultrasound? ( 29042095 )
2017
10
Cost-Utility of Evaluation for Posterior Vitreous Detachment and Prophylaxis of Retinal Detachment. ( 28732590 )
2017
11
Assessment of posterior vitreous detachment on enhanced high density line optical coherence tomography. ( 28149795 )
2017
12
Degradation of Contrast Sensitivity Function Following Posterior Vitreous Detachment. ( 28236439 )
2017
13
Response to Re: Evaluation of posterior vitreous detachment after uneventful phacoemulsification surgery by optical coherence tomography and ultrasonography. ( 28971519 )
2017
14
The Role of Posterior Vitreous Detachment and Vitreomacular Adhesion in Patients With Age-Related Macular Degeneration. ( 28297034 )
2017
15
Re: Evaluation of posterior vitreous detachment after uneventful phacoemulsification surgery by optical coherence tomography and ultrasonography. ( 28975671 )
2017
16
Posterior vitreous detachment - prevalence of and risk factors for retinal tears. ( 29075095 )
2017
17
Risk factors for multiple retinal tears in patients with acute posterior vitreous detachment. ( 28160191 )
2017
18
An unusual pathological posterior vitreous detachment. ( 28503754 )
2017
19
PARS PLANA VITRECTOMY AND LENSECTOMY FOR ECTOPIA LENTIS WITH AND WITHOUT THE INDUCTION OF A POSTERIOR VITREOUS DETACHMENT. ( 28207607 )
2017
20
Posterior Vitreous Detachment and the Posterior Hyaloid Membrane. ( 28867131 )
2017
21
PERIPAPILLARY RETINAL NERVE FIBER THICKNESS CHANGES AFTER VITRECTOMY FOR EPIRETINAL MEMBRANE IN EYES WITH AND WITHOUT VITREOUS DETACHMENT. ( 28098728 )
2017
22
NOVEL SURGICAL TECHNIQUE FOR INDUCING POSTERIOR VITREOUS DETACHMENT DURING PARS PLANA VITRECTOMY FOR PEDIATRIC PATIENTS USING A FLEXIBLE LOOP. ( 29176537 )
2017
23
Optic Nerve Head Hemorrhages Associated With Posterior Vitreous Detachment. ( 29063741 )
2017
24
Vitreous Hyper-Reflective Dots in Optical Coherence Tomography and Retinal Tear in Patients with Acute Posterior Vitreous Detachment. ( 28358220 )
2017
25
Incidence of Posterior Vitreous Detachment After Femtosecond LASIK Compared With Microkeratome LASIK. ( 28708815 )
2017
26
Posterior vitreous detachment and macular anatomical changes - a tomographic-electroretinographic study. ( 27833968 )
2016
27
Possible Relation between Lack of Posterior Vitreous Detachment and Severe Endogenous Endophthalmitis. ( 27766175 )
2016
28
Ranibizumab Versus Bevacizumab for Neovascular Age-Related Macular Degeneration With an Incomplete Posterior Vitreous Detachment. ( 26692256 )
2016
29
Prevalence of posterior vitreous detachment in glaucoma patients and controls. ( 27966831 )
2016
30
Posterior Vitreous Detachment Associated with Non-arteritic Ischaemic Optic Neuropathy. ( 27928412 )
2016
31
SCLERAL BUCKLE SURGERY FOR PRIMARY RETINAL DETACHMENT WITHOUT POSTERIOR VITREOUS DETACHMENT. ( 27172097 )
2016
32
Spectral domain optical coherence tomography and B-scan ultrasonography in the evaluation of retinal tears in acute, incomplete posterior vitreous detachment. ( 27215604 )
2016
33
Evaluation of posterior vitreous detachment after uneventful phacoemulsification surgery by optical coherence tomography and ultrasonography. ( 27435335 )
2016
34
Partial posterior vitreous detachment as a classification criterion of epiretinal membrane. ( 26929594 )
2016
35
Degradation of Contrast Sensitivity Function Following Posterior Vitreous Detachment. ( 27633841 )
2016
36
Induction of Posterior Vitreous Detachment in Pediatric Vitrectomy by Preoperative Intravitreal Injection of Tissue Plasminogen Activator. ( 27018884 )
2016
37
Relationship between variations in posterior vitreous detachment and visual prognosis in idiopathic epiretinal membranes. ( 26730176 )
2016
38
Surgical induction of posterior vitreous detachment using combined sharp dissection and active aspiration. ( 26833701 )
2016
39
POSTERIOR VITREOUS DETACHMENT IN HIGHLY MYOPIC EYES UNDERGOING VITRECTOMY. ( 26669837 )
2016
40
Spontaneous resolution of foveal detachment in traction maculopathy in high myopia unrelated to posterior vitreous detachment. ( 26868376 )
2016
41
Spontaneous resolution of optic disc pit maculopathy after posterior vitreous detachment. ( 26874168 )
2016
42
Spectral-Domain Optical Coherence Tomography in Acute Posterior Vitreous Detachment. ( 25935788 )
2015
43
Small-Gauge Pars Plana Vitrectomy for the Management of Symptomatic Posterior Vitreous Detachment after Phacoemulsification and Multifocal Intraocular Lens Implantation: A Pilot Study from the Pan-American Collaborative Retina Study Group. ( 26504590 )
2015
44
Low prevalence of anterior vitreous detachment in eyes with pseudophakic retinal detachment indicates strong vitreoretinal adhesions. ( 25627148 )
2015
45
Effects of posterior vitreous detachment on aqueous humour levels of VEGF and inflammatory cytokines. ( 25722492 )
2015
46
VITREOMACULAR TRACTION AFTER DEXAMETHASONE INTRAVITREAL IMPLANT (OZURDEX) INJECTION: THE EFFECT OF ANOMALOUS POSTERIOR VITREOUS DETACHMENT. ( 26121307 )
2015
47
The incidence of retinal breaks in the presenting and fellow eyes in patients with acute symptomatic posterior vitreous detachment and their associated risk factors. ( 26068606 )
2015
48
Influence of posterior vitreous detachment and type of intraocular lens on lipid peroxidation in the human vitreous. ( 26396488 )
2015
49
Incidence, Progression, and Associated Risk Factors of Posterior Vitreous Detachment in Type 2 Diabetes Mellitus: Sankara Nethralaya Diabetic Retinopathy Epidemiology and Molecular Genetic Study (SN-DREAMS II, Report No. 7). ( 26146895 )
2015
50
Effect of posterior vitreous detachment on aqueous humor level of vascular endothelial growth factor in exudative age-related macular degeneration patients. ( 25863675 )
2015
Sources

Variations for Vitreous Detachment

About this section
Sources

Expression for Vitreous Detachment

About this section
Search GEO for disease gene expression data for Vitreous Detachment.
Sources

Pathways for Vitreous Detachment

About this section

Pathways related to Vitreous Detachment according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Degradation of the extracellular matrix 66
Show member pathways
 12.09 LAMA3 OPTC PLG
2
Cell adhesion_ECM remodeling 22
10.94 LAMA3 PLG
3
Cell adhesion_Plasmin signaling 22
10.65 PLG VEGFA
4
Syndecan-4-mediated signaling events 1
10.11 LAMA3 PLG
Sources

GO Terms for Vitreous Detachment

About this section

Cellular components related to Vitreous Detachment according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet alpha granule lumen GO:0031093 8.62 PLG VEGFA

Biological processes related to Vitreous Detachment according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet degranulation GO:0002576 8.96 PLG VEGFA
2 extracellular matrix disassembly GO:0022617 8.8 LAMA3 OPTC PLG
Sources

Sources for Vitreous Detachment

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....