MCID: VTR005
MIFTS: 41

Vitreous Disease

Categories: Eye diseases

Aliases & Classifications for Vitreous Disease

MalaCards integrated aliases for Vitreous Disease:

Name: Vitreous Disease 12 15
Disorder of Vitreous Body 71

Classifications:



External Ids:

Disease Ontology 12 DOID:9720
ICD9CM 34 379.24
UMLS 71 C0029872 C0155365

Summaries for Vitreous Disease

Disease Ontology : 12 An eye and adnexa disease that is located in the vitreous of the eye.

MalaCards based summary : Vitreous Disease, also known as disorder of vitreous body, is related to vitreoretinopathy, neovascular inflammatory and endophthalmitis. An important gene associated with Vitreous Disease is TGFB2 (Transforming Growth Factor Beta 2), and among its related pathways/superpathways are Signaling by GPCR and ERK Signaling. The drugs Cyclophosphamide and Lenograstim have been mentioned in the context of this disorder. Affiliated tissues include eye, bone and retina, and related phenotypes are cardiovascular system and homeostasis/metabolism

Related Diseases for Vitreous Disease

Diseases related to Vitreous Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 245)
# Related Disease Score Top Affiliating Genes
1 vitreoretinopathy, neovascular inflammatory 31.0 VEGFA TJP1 TGFB2 RPE65 RLBP1 GFAP
2 endophthalmitis 29.8 VEGFA PLG IL6 CXCL8 CRYAA
3 macular holes 29.2 VEGFA TGFB2 RPE65 PLG OPTC FN1
4 retinal detachment 28.5 VEGFA RHO PDGFA IL6 GFAP FGF2
5 cataract 28.4 VEGFA TJP1 TGFB2 RHO PAX6 OTX2
6 persistent hyperplastic primary vitreous 11.1
7 vitreous abscess 11.1
8 upper lip cancer 10.6 TGFB2 FGF2
9 pauci-immune glomerulonephritis 10.6 SMAD2 CCN2
10 central retinal artery occlusion 10.5 VEGFA PLG CRYAA
11 fryns microphthalmia syndrome 10.5 PAX6 OTX2
12 osteosclerotic myeloma 10.5 VEGFA IL6
13 mycobacterium kansasii 10.5 FN1 CXCL8
14 retinal ischemia 10.5 VEGFA FGF2 CRYAA
15 autoimmune disease of eyes, ear, nose and throat 10.5 RLBP1 IL6 CRYAA
16 vascular cancer 10.5 VEGFA PLG FGF2
17 solar retinopathy 10.4 RLBP1 RHO
18 trachoma 10.4 VEGFA IL6 CCN2
19 intussusception 10.4 VEGFA IL6 FGF2
20 ischemic bone disease 10.4 VEGFA IL6 FGF2
21 idiopathic anterior uveitis 10.4 IL6 CXCL8
22 moyamoya disease 1 10.4 VEGFA PLG FGF2
23 nephrosclerosis 10.4 VEGFA CCN2 CCL2
24 macular degeneration, age-related, 2 10.4 VEGFA RPE65 RHO
25 yemenite deaf-blind hypopigmentation syndrome 10.4 VEGFA RPE65 RHO
26 central retinal vein occlusion 10.4 VEGFA PLG IL6
27 newfoundland rod-cone dystrophy 10.4 RLBP1 RHO
28 streptococcal toxic-shock syndrome 10.4 IL6 CXCL8
29 leber congenital amaurosis 2 10.4 RPE65 RHO CRYAA
30 pulmonary artery disease 10.4 VEGFA PLG IL6
31 acute transverse myelitis 10.4 IL6 CXCL8
32 gyrate atrophy of choroid and retina 10.4 RPE65 RHO CRYAA
33 pericardial effusion 10.4 VEGFA IL6 FGF2
34 scotoma 10.4 VEGFA RPE65 RHO
35 proliferative glomerulonephritis 10.4 IL6 CCN2 CCL2
36 osteonecrosis 10.4 VEGFA PLG FGF2
37 rubeosis iridis 10.4 VEGFA PLG
38 hepatic vascular disease 10.4 VEGFA PLG IL6
39 background diabetic retinopathy 10.4 VEGFA IL6 CCL2
40 peyronie's disease 10.4 TGFB2 IL6 CCL2
41 color blindness 10.4 RPE65 RHO CRYAA
42 hereditary retinal dystrophy 10.4 RPE65 RHO FGF2
43 corneal neovascularization 10.4 VEGFA PLG FGF2 CRYAA
44 tuberculous meningitis 10.4 VEGFA CXCL8 CCL2
45 amblyopia 10.4 PAX6 OTX2 CRYAA
46 vitreous detachment 10.4 VEGFA PLG OPTC FN1
47 dry eye syndrome 10.4 IL6 FGF2 CRYAA
48 leukostasis 10.4 VEGFA IL6 CCL2
49 vein disease 10.4 VEGFA PLG IL6
50 pattern dystrophy 10.4 RHO OTX2

Graphical network of the top 20 diseases related to Vitreous Disease:



Diseases related to Vitreous Disease

Symptoms & Phenotypes for Vitreous Disease

MGI Mouse Phenotypes related to Vitreous Disease:

45 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.45 CCN2 FGF2 FN1 GFAP IL6 OPTC
2 homeostasis/metabolism MP:0005376 10.39 CCN2 FGF2 FN1 GFAP IL6 OTX2
3 cellular MP:0005384 10.38 CCN2 FGF2 FN1 GFAP IL6 OTX2
4 growth/size/body region MP:0005378 10.34 CCN2 FN1 GFAP IL6 OTX2 PAX6
5 mortality/aging MP:0010768 10.27 CCN2 FGF2 FN1 GFAP IL6 OTX2
6 digestive/alimentary MP:0005381 10.25 CCN2 GFAP IL6 OTX2 PAX6 PDGFA
7 immune system MP:0005387 10.24 CCL2 FN1 GFAP IL6 PAX6 PLG
8 nervous system MP:0003631 10.24 FGF2 FN1 GFAP IL6 OTX2 PAX6
9 craniofacial MP:0005382 10.21 CCN2 FN1 OTX2 PAX6 PDGFA RLBP1
10 embryo MP:0005380 10.19 CCN2 FN1 OTX2 PAX6 PDGFA SMAD2
11 integument MP:0010771 10.13 CCN2 FN1 IL6 PAX6 PDGFA PLG
12 muscle MP:0005369 10.09 FGF2 FN1 GFAP IL6 OTX2 PAX6
13 reproductive system MP:0005389 9.96 FGF2 FN1 IL6 OTX2 PAX6 PDGFA
14 neoplasm MP:0002006 9.95 FGF2 FN1 IL6 PAX6 PLG SMAD2
15 respiratory system MP:0005388 9.81 CCN2 IL6 OTX2 PAX6 PDGFA PLG
16 pigmentation MP:0001186 9.72 OTX2 PAX6 RHO RLBP1 RPE65
17 skeleton MP:0005390 9.7 CCN2 FGF2 FN1 IL6 OTX2 PAX6
18 vision/eye MP:0005391 9.47 CCN2 FGF2 GFAP IL6 OPTC OTX2

Drugs & Therapeutics for Vitreous Disease

Drugs for Vitreous Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
2
Lenograstim Approved, Investigational Phase 3 135968-09-1
3
Vincristine Approved, Investigational Phase 3 2068-78-2, 57-22-7 5978
4
Carboplatin Approved Phase 3 41575-94-4 10339178 498142 38904
5
Etoposide Approved Phase 3 33419-42-0 36462
6
Mesna Approved, Investigational Phase 3 3375-50-6 598
7
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
8
Topotecan Approved, Investigational Phase 3 119413-54-6, 123948-87-8 60700
9 Immunologic Factors Phase 3
10 Alkylating Agents Phase 3
11 Topoisomerase Inhibitors Phase 3
12 Immunosuppressive Agents Phase 3
13 Antirheumatic Agents Phase 3
14 Etoposide phosphate Phase 3
15 Antimitotic Agents Phase 3
16 Anti-Bacterial Agents Phase 3
17 topoisomerase I inhibitors Phase 3
18 Anesthetics Phase 3
19 Antibiotics, Antitubercular Phase 3
20
Liposomal doxorubicin Phase 3 31703
21
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
22
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 1 1177-87-3
23
Dexamethasone Approved, Investigational, Vet_approved Phase 1 50-02-2 5743
24
Polymyxin B Approved, Vet_approved Phase 1 1404-26-8
25
Neomycin Approved, Vet_approved Phase 1 1404-04-2 8378
26 Dexamethasone, neomycin, polymyxin B drug combination Phase 1
27 BB 1101 Phase 1
28 Polymyxins Phase 1
29 Anti-Infective Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Protocol for the Study and Treatment of Patients With Intraocular Retinoblastoma Active, not recruiting NCT00186888 Phase 3 Vincristine, Carboplatin;Vincristine and Topotecan;Vincristine + Carboplatin + Etoposide;vincristine, cyclophosphamide, and doxorubicin;Vincristine, Carboplatin and Etoposide
2 A TRIAL OF ADJUVANT CHEMOTHERAPY IN PATIENTS WITH INTRAOCULAR RETINOBLASTOMA Completed NCT00002675 Phase 2 carboplatin;cisplatin;cyclophosphamide;etoposide;mesna;vincristine sulfate
3 Intravitreal Carboplatin for the Treatment of Participants With Recurrent or Refractory Intraocular Retinoblastoma Recruiting NCT02792036 Phase 1 Carboplatin;Maxitrol®

Search NIH Clinical Center for Vitreous Disease

Genetic Tests for Vitreous Disease

Anatomical Context for Vitreous Disease

MalaCards organs/tissues related to Vitreous Disease:

40
Eye, Bone, Retina, Endothelial, Brain, Spinal Cord, Heart

Publications for Vitreous Disease

Articles related to Vitreous Disease:

(show all 22)
# Title Authors PMID Year
1
Intravitreal chemotherapy in retinoblastoma: expanded use beyond intravitreal seeds. 61
29875233 2019
2
Mapping research trends of retinal vein occlusion from 2009 to 2018: a bibliometric analysis. 61
31528507 2019
3
Vitreous Disease in Retinoblastoma: Clinical Findings and Treatment. 61
29034355 2017
4
Intravitreal chemotherapy in the management of vitreous disease in retinoblastoma. 61
28106239 2017
5
Classification of Vitreous Seeds in Retinoblastoma: Correlations with Patient, Tumor, and Treatment Characteristics. 61
27030103 2016
6
Feasibility and Outcome of Descemet Membrane Endothelial Keratoplasty in Complex Anterior Segment and Vitreous Disease. 61
26382893 2015
7
Ultrasound-based quantification of vitreous floaters correlates with contrast sensitivity and quality of life. 61
25613948 2015
8
Intravitreal chemotherapy for vitreous seeding in retinoblastoma: Recent advances and perspectives. 61
24227979 2013
9
Intravitreal chemotherapy for vitreous disease in retinoblastoma revisited: from prohibition to conditional indications. 61
22694968 2012
10
Profiling safety of intravitreal injections for retinoblastoma using an anti-reflux procedure and sterilisation of the needle track. 61
22368262 2012
11
[Effects of implementing clinical pathways for the care of patients undergoing ophthalmic surgery for cataract, glaucoma, and vitreoretinal disorder]. 61
16491870 2006
12
Lack of activity of oral etoposide for relapsed intraocular retinoblastoma. 61
15255111 2004
13
Concurrent vitreous disease may produce abnormal vitreous humour biochemistry and toxicology. 61
12944563 2003
14
A phase I/II study of subconjunctival carboplatin for intraocular retinoblastoma. 61
10519590 1999
15
Cutaneous melanoma metastatic to the vitreous cavity. 61
9544631 1998
16
Fluorescein blue, light-assisted capsulorhexis for mature or hypermature cataract. 61
9494894 1998
17
[Type I like collagen appeared in vitreous disease]. 61
3195393 1988
18
The significance of the pars plana exudate in pars planitis. 61
3578463 1987
19
Advances in the treatment of vitreous disease. 61
7062469 1982
20
Pars plana vitrectomy for asteroid hyalosis. 61
7348845 1981
21
Vitrectomy: a new challenge for the anesthesiologist. 61
1167762 1975
22
THE SURGERY OF THE VITREOUS: A preliminary paper dealing with an experimental Investigation into the Surgery of the Vitreous Body with special reference to its application in cases of Detached Retina, Primary Vitreous Disease, Haemorrhage or Traumatic loss of Vitreous. 61
18168883 1930

Variations for Vitreous Disease

Expression for Vitreous Disease

Search GEO for disease gene expression data for Vitreous Disease.

Pathways for Vitreous Disease

Pathways related to Vitreous Disease according to GeneCards Suite gene sharing:

(show all 49)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.18 VEGFA TJP1 SMAD2 RPE65 RLBP1 RHO
2
Show member pathways
13.77 VEGFA TGFB2 SMAD2 PDGFA PAX6 IL6
3
Show member pathways
13.53 VEGFA TGFB2 SMAD2 PDGFA IL6 FGF2
4
Show member pathways
13.36 VEGFA PDGFA IL6 FN1 FGF2 CXCL8
5
Show member pathways
13.27 TJP1 TGFB2 PDGFA IL6 FGF2 CXCL8
6
Show member pathways
13.07 TGFB2 PDGFA IL6 FN1 FGF2 CCN2
7
Show member pathways
13.06 TGFB2 PDGFA IL6 FGF2 CCN2 CCL2
8
Show member pathways
12.71 TGFB2 PLG PDGFA OPTC FN1 FGF2
9
Show member pathways
12.7 TGFB2 PDGFA IL6 FGF2 CCN2
10 12.7 VEGFA TGFB2 SMAD2 PDGFA IL6 FN1
11
Show member pathways
12.61 VEGFA TGFB2 PDGFA IL6 FGF2
12
Show member pathways
12.53 PLG PDGFA IL6 FN1 FGF2 CCL2
13
Show member pathways
12.38 TGFB2 PDGFA PAX6 IL6 FGF2 CCN2
14 12.27 VEGFA TGFB2 SMAD2 FN1 FGF2
15
Show member pathways
12.23 VEGFA SMAD2 FN1 FGF2
16
Show member pathways
12.22 TGFB2 PDGFA IL6 FGF2 CXCL8 CCN2
17 12.18 VEGFA TGFB2 SMAD2 IL6
18 12.16 TGFB2 SMAD2 IL6 CXCL8
19 12.01 IL6 FN1 CXCL8 CCL2
20 12 IL6 GFAP CXCL8 CCL2
21 11.98 VEGFA PAX6 OTX2 IL6 FGF2
22 11.9 TGFB2 IL6 FN1 CXCL8
23 11.83 TGFB2 FGF2 CCL2
24 11.8 VEGFA TGFB2 IL6 CXCL8 CCL2
25 11.79 VEGFA IL6 FN1 FGF2 CXCL8 CCL2
26 11.78 TJP1 IL6 CXCL8
27 11.73 TGFB2 PDGFA IL6 FGF2 CCN2
28 11.7 TGFB2 PDGFA IL6 CCL2
29 11.7 VEGFA PDGFA PAX6 GFAP FGF2
30 11.68 VEGFA TGFB2 FGF2
31
Show member pathways
11.67 VEGFA IL6 CXCL8
32 11.65 PLG FN1 CXCL8
33
Show member pathways
11.6 RPE65 RLBP1 RHO
34 11.6 TGFB2 IL6 CXCL8
35 11.55 VEGFA IL6 CXCL8
36 11.53 IL6 CXCL8 CCL2
37 11.51 TGFB2 IL6 CXCL8 CCL2
38 11.49 VEGFA FN1 FGF2
39 11.48 VEGFA PDGFA IL6 FGF2
40 11.46 VEGFA PDGFA FGF2
41 11.46 PLG IL6 FN1 CCN2
42 11.41 VEGFA TGFB2 PLG FN1 FGF2
43 11.34 IL6 CXCL8 CCL2
44 11.28 PLG FN1 FGF2
45 11.23 PDGFA IL6 FGF2 CXCL8 CCN2 CCL2
46 11.19 VEGFA SMAD2 FGF2
47 11.17 VEGFA TGFB2 SMAD2 IL6 FN1 CXCL8
48 11.03 IL6 FN1 CXCL8
49 10.71 TGFB2 PDGFA IL6 GFAP FN1 FGF2

GO Terms for Vitreous Disease

Cellular components related to Vitreous Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.9 VEGFA TGFB2 PLG PDGFA OPTC IL6
2 extracellular space GO:0005615 9.65 VEGFA TGFB2 PLG PDGFA IL6 FN1
3 cell body GO:0044297 9.43 RPE65 RLBP1 GFAP
4 platelet alpha granule lumen GO:0031093 9.02 VEGFA TGFB2 PLG PDGFA FN1

Biological processes related to Vitreous Disease according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.95 VEGFA SMAD2 PAX6 IL6 FN1 CCN2
2 positive regulation of cell proliferation GO:0008284 9.95 VEGFA TGFB2 PDGFA IL6 FN1 FGF2
3 negative regulation of cell proliferation GO:0008285 9.93 TGFB2 SMAD2 PLG PAX6 IL6 CXCL8
4 extracellular matrix organization GO:0030198 9.9 PDGFA GFAP FN1 FGF2
5 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.88 PDGFA FGF2 CCN2 CCL2
6 cytokine-mediated signaling pathway GO:0019221 9.85 VEGFA IL6 FN1 FGF2 CXCL8 CCL2
7 visual perception GO:0007601 9.83 RPE65 RLBP1 RHO PAX6 CRYAA
8 animal organ morphogenesis GO:0009887 9.8 PDGFA PAX6 FGF2 CCL2
9 neutrophil chemotaxis GO:0030593 9.78 TGFB2 CXCL8 CCL2
10 retina development in camera-type eye GO:0060041 9.75 RPE65 RHO PAX6
11 retinoid metabolic process GO:0001523 9.73 RPE65 RLBP1 RHO
12 positive regulation of MAP kinase activity GO:0043406 9.72 VEGFA PDGFA FGF2
13 positive regulation of epithelial to mesenchymal transition GO:0010718 9.69 TGFB2 SMAD2 IL6
14 platelet degranulation GO:0002576 9.65 VEGFA TGFB2 PLG PDGFA FN1
15 positive regulation of cell division GO:0051781 9.62 VEGFA TGFB2 PDGFA FGF2
16 PERK-mediated unfolded protein response GO:0036499 9.61 CXCL8 CCL2
17 salivary gland morphogenesis GO:0007435 9.59 TGFB2 PAX6
18 negative regulation of cell-cell adhesion mediated by cadherin GO:2000048 9.57 VEGFA PLG
19 wound healing GO:0042060 9.55 TGFB2 SMAD2 PDGFA FN1 FGF2
20 vitamin A metabolic process GO:0006776 9.54 RPE65 RLBP1
21 interaction with symbiont GO:0051702 9.52 PLG FN1
22 response to wounding GO:0009611 9.43 TGFB2 PDGFA PAX6 GFAP FN1 CCN2
23 angiogenesis GO:0001525 9.23 VEGFA TGFB2 PDGFA FN1 FGF2 CXCL8

Molecular functions related to Vitreous Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.21 VEGFA TJP1 TGFB2 SMAD2 RHO PLG
2 heparin binding GO:0008201 9.62 VEGFA FN1 FGF2 CCN2
3 cytokine activity GO:0005125 9.43 VEGFA TGFB2 IL6 FGF2 CXCL8 CCL2
4 11-cis retinal binding GO:0005502 9.16 RLBP1 RHO
5 growth factor activity GO:0008083 9.1 VEGFA TGFB2 PDGFA IL6 FGF2 CCN2

Sources for Vitreous Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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