Aliases & Classifications for Vitreous Disease

MalaCards integrated aliases for Vitreous Disease:

Name: Vitreous Disease 12 15
Disorder of Vitreous Body 73

Classifications:



External Ids:

Disease Ontology 12 DOID:9720
ICD10 33 H43.3 H43.39
ICD9CM 35 379.24
SNOMED-CT 68 194154006 194636006

Summaries for Vitreous Disease

Disease Ontology : 12 An eye and adnexa disease that is located in the vitreous of the eye.

MalaCards based summary : Vitreous Disease, also known as disorder of vitreous body, is related to neovascular glaucoma and melorheostosis. An important gene associated with Vitreous Disease is TGFB2 (Transforming Growth Factor Beta 2), and among its related pathways/superpathways are ERK Signaling and TGF-Beta Pathway. The drugs Carboplatin and Etoposide have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and retina, and related phenotypes are cardiovascular system and homeostasis/metabolism

Related Diseases for Vitreous Disease

Diseases related to Vitreous Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 33)
# Related Disease Score Top Affiliating Genes
1 neovascular glaucoma 10.6 TGFB2 VEGFA
2 melorheostosis 10.6 FGF2 SMAD2
3 pauci-immune glomerulonephritis 10.6 CTGF SMAD2
4 angiodysplasia 10.5 FGF2 VEGFA
5 stiff skin syndrome 10.5 CTGF TGFB2
6 radiation proctitis 10.5 FGF2 VEGFA
7 cornea cancer 10.5 FGF2 GFAP
8 corneal disease 10.4 FGF2 TGFB2 VEGFA
9 blood group, globoside system 10.4 PLG VEGFA
10 chronic myocardial ischemia 10.4 FGF2 PLG VEGFA
11 eye degenerative disease 10.4 KCNJ13 VEGFA
12 corneal neovascularization 10.4 FGF2 PLG VEGFA
13 vitreous detachment 10.3 OPTC PLG VEGFA
14 endophthalmitis 10.3 PLG VEGFA
15 angiomatous meningioma 10.3 FGF2 GFAP VEGFA
16 retinal vascular disease 10.3 CTGF PLG VEGFA
17 cerebral ventricle cancer 10.2 GFAP KCNJ13
18 microcystic meningioma 10.2 GFAP VEGFA
19 retinal perforation 10.1 KCNJ13 PAX6
20 connective tissue cancer 10.1 FGF2 PDGFB VEGFA
21 keratitis, hereditary 10.1 FGF2 PAX6 VEGFA
22 microvascular complications of diabetes 1 10.1 CTGF FGF2 TGFB2 VEGFA
23 kaposi sarcoma 10.0 FGF2 PDGFB VEGFA
24 brown-sequard syndrome 10.0 GFAP PLG
25 retinal vascular occlusion 9.9 PLG VEGFA
26 preretinal fibrosis 9.9 GFAP RLBP1 TGFB2 VEGFA
27 retinoblastoma 9.8
28 pulmonary fibrosis, idiopathic 9.7 CTGF FGF2 PDGFB SMAD2
29 endotheliitis 9.6
30 retinal detachment 9.4 GFAP KCNJ13 PDGFB VEGFA
31 vitreoretinopathy, neovascular inflammatory 8.9 CTGF FGF2 GFAP TGFB2 VTN
32 macular degeneration, age-related, 1 8.6 FGF2 OPTC PLG RLBP1 VEGFA VTN
33 ewing sarcoma 8.4 CTGF FGF2 GFAP PAX6 PDGFB TGFB2

Graphical network of the top 20 diseases related to Vitreous Disease:



Diseases related to Vitreous Disease

Symptoms & Phenotypes for Vitreous Disease

MGI Mouse Phenotypes related to Vitreous Disease:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.29 CTGF EMP2 FGF2 GFAP OPTC PAX6
2 homeostasis/metabolism MP:0005376 10.13 CTGF FGF2 GFAP PAX6 PDGFB PLG
3 digestive/alimentary MP:0005381 10.08 TGFB2 VEGFA CTGF GFAP KCNJ13 PAX6
4 mortality/aging MP:0010768 10.07 PDGFB PLG SMAD2 TGFB2 VEGFA CTGF
5 embryo MP:0005380 10 CTGF EMP2 PAX6 PDGFB SMAD2 TGFB2
6 craniofacial MP:0005382 9.97 KCNJ13 PAX6 SMAD2 TGFB2 VEGFA CTGF
7 nervous system MP:0003631 9.97 PAX6 PDGFB PLG RLBP1 SMAD2 TGFB2
8 integument MP:0010771 9.95 CTGF PAX6 PDGFB PLG RLBP1 SMAD2
9 reproductive system MP:0005389 9.86 EMP2 FGF2 PAX6 PDGFB PLG SMAD2
10 respiratory system MP:0005388 9.76 CTGF KCNJ13 PAX6 PDGFB PLG SMAD2
11 skeleton MP:0005390 9.56 CTGF FGF2 KCNJ13 PAX6 RLBP1 SMAD2
12 vision/eye MP:0005391 9.36 SMAD2 TGFB2 VEGFA CTGF FGF2 GFAP

Drugs & Therapeutics for Vitreous Disease

Drugs for Vitreous Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carboplatin Approved Phase 3,Phase 1 41575-94-4 10339178 498142 38904
2
Etoposide Approved Phase 3 33419-42-0 36462
3
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
4
Mesna Approved, Investigational Phase 3 3375-50-6 598
5
Topotecan Approved, Investigational Phase 3 119413-54-6, 123948-87-8 60700
6
Vincristine Approved, Investigational Phase 3 2068-78-2, 57-22-7 5978
7
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
8
Doxil Approved June 1999 Phase 3 31703
9 Anti-Bacterial Agents Phase 3,Phase 1
10 Alkylating Agents Phase 3
11 topoisomerase I inhibitors Phase 3
12 Anesthetics Phase 3
13 Topoisomerase Inhibitors Phase 3
14 Antibiotics, Antitubercular Phase 3
15 Etoposide phosphate Phase 3
16 Immunosuppressive Agents Phase 3
17 Antirheumatic Agents Phase 3
18 Antimitotic Agents Phase 3
19 Antineoplastic Agents, Alkylating Phase 3
20 Antineoplastic Agents, Phytogenic Phase 3
21
Dexamethasone Approved, Investigational, Vet_approved Phase 1 50-02-2 5743
22
Neomycin Approved, Vet_approved Phase 1 1404-04-2 8378
23 Polymyxin B Phase 1
24 Dexamethasone acetate Phase 1 1177-87-3
25 Dexamethasone, neomycin, polymyxin B drug combination Phase 1
26 Polymyxins Phase 1
27 Anti-Infective Agents Phase 1
28 BB 1101 Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of Treatment for Patients With Cancer of the Eye -Retinoblastoma Active, not recruiting NCT00186888 Phase 3 Vincristine, Carboplatin;Vincristine + Topotecan;Vincristine + Carboplatin + Etoposide;Vincristine + Cyclophosphamide + Doxorubicin;Vincristine+Carboplatin+Etoposide
2 Intravitreal Carboplatin for the Treatment of Participants With Recurrent or Refractory Intraocular Retinoblastoma Recruiting NCT02792036 Phase 1 Carboplatin;Maxitrol®
3 Advanced OCT and Adaptive Optics Imaging in Retinal Disease (The ACAD Study) Recruiting NCT02828215
4 OCT in Rare Chorioretinal Diseases Recruiting NCT02141308

Search NIH Clinical Center for Vitreous Disease

Genetic Tests for Vitreous Disease

Anatomical Context for Vitreous Disease

MalaCards organs/tissues related to Vitreous Disease:

41
Eye, Endothelial, Retina

Publications for Vitreous Disease

Articles related to Vitreous Disease:

# Title Authors Year
1
Vitreous Disease in Retinoblastoma: Clinical Findings and Treatment. ( 29034355 )
2017
2
Intravitreal chemotherapy in the management of vitreous disease in retinoblastoma. ( 28106239 )
2017
3
Feasibility and Outcome of Descemet Membrane Endothelial Keratoplasty in Complex Anterior Segment and Vitreous Disease. ( 26382893 )
2015
4
Intravitreal chemotherapy for vitreous disease in retinoblastoma revisited: from prohibition to conditional indications. ( 22694968 )
2012
5
Concurrent vitreous disease may produce abnormal vitreous humour biochemistry and toxicology. ( 12944563 )
2003
6
Advances in the treatment of vitreous disease. ( 7062469 )
1982
7
THE SURGERY OF THE VITREOUS: A preliminary paper dealing with an experimental Investigation into the Surgery of the Vitreous Body with special reference to its application in cases of Detached Retina, Primary Vitreous Disease, Haemorrhage or Traumatic loss of Vitreous. ( 18168883 )
1930

Variations for Vitreous Disease

Expression for Vitreous Disease

Search GEO for disease gene expression data for Vitreous Disease.

Pathways for Vitreous Disease

Pathways related to Vitreous Disease according to GeneCards Suite gene sharing:

(show all 28)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.69 CTGF FGF2 GFAP PAX6 PDGFB SMAD2
2
Show member pathways
13.35 CTGF FGF2 PDGFB SMAD2 TGFB2 VEGFA
3 12.68 FGF2 PDGFB SMAD2 TGFB2 VEGFA
4
Show member pathways
12.52 CTGF FGF2 PDGFB TGFB2
5
Show member pathways
12.4 FGF2 PDGFB TGFB2 VEGFA
6
Show member pathways
12.39 FGF2 OPTC PDGFB PLG TGFB2 VTN
7
Show member pathways
12.31 FGF2 PDGFB SMAD2 TGFB2
8 12.03 SMAD2 TGFB2 VEGFA
9 11.97 CTGF SMAD2 TGFB2
10 11.92 FGF2 PAX6 SMAD2
11
Show member pathways
11.87 CTGF FGF2 PDGFB SMAD2 TGFB2
12 11.86 FGF2 SMAD2 TGFB2 VEGFA VTN
13 11.83 FGF2 PAX6 PDGFB VEGFA
14 11.75 SMAD2 TGFB2 VEGFA
15
Show member pathways
11.55 FGF2 PDGFB VTN
16 11.53 FGF2 TGFB2 VEGFA
17 11.5 CTGF FGF2 PDGFB
18 11.37 CTGF PLG VTN
19 11.35 FGF2 PDGFB VEGFA
20
Show member pathways
11.32 SMAD2 TGFB2
21 11.32 FGF2 VEGFA VTN
22 11.23 FGF2 PDGFB VEGFA
23 11.02 CTGF SMAD2
24 10.96 FGF2 SMAD2 VEGFA
25 10.95 FGF2 PLG TGFB2 VEGFA
26 10.92 FGF2 GFAP PAX6 PDGFB VEGFA
27 10.91 IGFBP6 PLG
28 10.88 FGF2 PDGFB VEGFA

GO Terms for Vitreous Disease

Cellular components related to Vitreous Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.76 CTGF FGF2 IGFBP6 PDGFB PLG TGFB2
2 extracellular region GO:0005576 9.61 CTGF FGF2 IGFBP6 OPTC PDGFB PLG
3 platelet alpha granule lumen GO:0031093 8.92 PDGFB PLG TGFB2 VEGFA

Biological processes related to Vitreous Disease according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.89 CTGF FGF2 PDGFB TGFB2 VEGFA
2 negative regulation of cell proliferation GO:0008285 9.88 IGFBP6 PAX6 PLG SMAD2 TGFB2
3 angiogenesis GO:0001525 9.86 CTGF FGF2 TGFB2 VEGFA
4 cell migration GO:0016477 9.84 CTGF EMP2 TGFB2 VTN
5 positive regulation of gene expression GO:0010628 9.83 CTGF PAX6 PDGFB SMAD2 VEGFA
6 extracellular matrix organization GO:0030198 9.81 FGF2 GFAP PDGFB VTN
7 positive regulation of cell proliferation GO:0008284 9.8 CTGF EMP2 FGF2 PDGFB TGFB2 VEGFA
8 cell-matrix adhesion GO:0007160 9.77 CTGF EMP2 VTN
9 lung development GO:0030324 9.77 CTGF SMAD2 VEGFA
10 wound healing GO:0042060 9.76 FGF2 SMAD2 TGFB2
11 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.75 PDGFB VEGFA VTN
12 positive regulation of endothelial cell proliferation GO:0001938 9.72 FGF2 PDGFB VEGFA
13 positive regulation of MAP kinase activity GO:0043406 9.7 FGF2 PDGFB VEGFA
14 platelet degranulation GO:0002576 9.67 PDGFB PLG TGFB2 VEGFA
15 positive regulation of sprouting angiogenesis GO:1903672 9.65 FGF2 VEGFA
16 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.65 PDGFB TGFB2
17 positive regulation of protein autophosphorylation GO:0031954 9.64 PDGFB VEGFA
18 signal transduction involved in regulation of gene expression GO:0023019 9.64 PAX6 SMAD2
19 positive regulation of neuroblast proliferation GO:0002052 9.63 PAX6 VEGFA
20 positive regulation of smooth muscle cell migration GO:0014911 9.63 PDGFB VTN
21 positive regulation of blood vessel endothelial cell migration GO:0043536 9.63 FGF2 PDGFB VEGFA
22 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.62 VEGFA VTN
23 eye photoreceptor cell development GO:0042462 9.62 PAX6 VEGFA
24 cell migration involved in sprouting angiogenesis GO:0002042 9.61 FGF2 VEGFA
25 secondary palate development GO:0062009 9.61 SMAD2 TGFB2
26 positive chemotaxis GO:0050918 9.58 FGF2 PDGFB VEGFA
27 salivary gland morphogenesis GO:0007435 9.57 PAX6 TGFB2
28 activation of protein kinase activity GO:0032147 9.56 EMP2 PDGFB TGFB2 VEGFA
29 negative regulation of gene expression GO:0010629 9.55 CTGF PDGFB SMAD2 TGFB2 VEGFA
30 positive regulation of cell division GO:0051781 9.26 FGF2 PDGFB TGFB2 VEGFA
31 response to wounding GO:0009611 9.02 CTGF GFAP PAX6 PDGFB TGFB2

Molecular functions related to Vitreous Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 9.56 CTGF FGF2 VEGFA VTN
2 kinase binding GO:0019900 9.54 EMP2 GFAP PLG
3 fibronectin binding GO:0001968 9.48 CTGF VEGFA
4 insulin-like growth factor binding GO:0005520 9.46 CTGF IGFBP6
5 R-SMAD binding GO:0070412 9.43 PAX6 SMAD2
6 platelet-derived growth factor receptor binding GO:0005161 9.4 PDGFB VEGFA
7 growth factor activity GO:0008083 9.35 CTGF FGF2 PDGFB TGFB2 VEGFA
8 chemoattractant activity GO:0042056 9.33 FGF2 PDGFB VEGFA
9 co-SMAD binding GO:0070410 9.32 PAX6 SMAD2
10 integrin binding GO:0005178 9.02 CTGF EMP2 FGF2 GFAP VTN

Sources for Vitreous Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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