MCID: VTR005
MIFTS: 45

Vitreous Disease

Categories: Eye diseases

Aliases & Classifications for Vitreous Disease

MalaCards integrated aliases for Vitreous Disease:

Name: Vitreous Disease 12 15
Disorder of Vitreous Body 74

Classifications:



External Ids:

Disease Ontology 12 DOID:9720
ICD9CM 36 379.24

Summaries for Vitreous Disease

Disease Ontology : 12 An eye and adnexa disease that is located in the vitreous of the eye.

MalaCards based summary : Vitreous Disease, also known as disorder of vitreous body, is related to persistent hyperplastic primary vitreous and cornea cancer. An important gene associated with Vitreous Disease is TGFB2 (Transforming Growth Factor Beta 2), and among its related pathways/superpathways are ERK Signaling and TGF-Beta Pathway. The drugs Carboplatin and Doxorubicin have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and endothelial, and related phenotypes are cardiovascular system and hematopoietic system

Wikipedia : 77 The vitreous body is the clear gel that fills the space between the lens and the retina of the eyeball... more...

Related Diseases for Vitreous Disease

Diseases related to Vitreous Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Related Disease Score Top Affiliating Genes
1 persistent hyperplastic primary vitreous 11.0
2 cornea cancer 10.3 FGF2 GFAP
3 microcystic meningioma 10.2 GFAP VEGFA
4 neovascular glaucoma 10.2 TGFB2 VEGFA
5 endometrial adenocarcinoma 10.2 EMP2 FGF2 VEGFA
6 connective tissue cancer 10.2 FGF2 PDGFB VEGFA
7 angiomatous meningioma 10.2 FGF2 GFAP VEGFA
8 chronic myocardial ischemia 10.2 FGF2 PLG VEGFA
9 corneal neovascularization 10.2 FGF2 PLG VEGFA
10 vitreous detachment 10.2 OPTC PLG VEGFA
11 angiodysplasia 10.2 FGF2 VEGFA
12 retinal detachment 10.1 GFAP PDGFB VEGFA
13 meningioma, familial 10.1 GFAP PDGFB VEGFA
14 kaposi sarcoma 10.1 FGF2 PDGFB VEGFA
15 macular holes 10.1 CCL2 TGFB2 VEGFA
16 diabetic macular edema 10.0 CCL2 FGF2 VEGFA
17 preretinal fibrosis 10.0 GFAP RLBP1 TGFB2 VEGFA
18 stiff skin syndrome 10.0 TGFB1 TGFB2
19 retinal vascular occlusion 10.0 CCL2 PLG VEGFA
20 radiation proctitis 10.0 FGF2 VEGFA
21 retinoblastoma 10.0
22 brain cancer 10.0 FGF2 GFAP PDGFB VEGFA
23 retinal vascular disease 9.9 CCL2 PLG VEGFA
24 laryngitis 9.9 FGF2 TGFB1
25 arteries, anomalies of 9.9 CCL2 PLG VEGFA
26 dupuytren contracture 9.9 FGF2 TGFB1 VEGFA
27 septicemic plague 9.9 PLG VTN
28 giant hemangioma 9.9 PLG TGFB1
29 differentiated thyroid carcinoma 9.9 FN1 TGFB1 VEGFA
30 gingival overgrowth 9.9 FGF2 PDGFB TGFB1
31 neuroma 9.8 FGF2 GFAP TGFB1
32 vascular disease 9.8 CCL2 FGF2 PLG VEGFA
33 nervous system disease 9.8 CCL2 GFAP PLG VEGFA
34 central nervous system disease 9.7 CCL2 GFAP PLG
35 peyronie's disease 9.7 CCL2 TGFB1 TGFB2
36 tuberculous meningitis 9.7 CCL2 TGFB1 VEGFA
37 nonspecific interstitial pneumonia 9.7 CCL2 FGF2 TGFB1
38 diabetic foot ulcers 9.7 CCL2 PDGFB TGFB1
39 idiopathic interstitial pneumonia 9.7 CCL2 TGFB1 VEGFA
40 urinary tract obstruction 9.7 CCL2 SMAD2 TGFB1
41 renal fibrosis 9.7 CCL2 SMAD2 TGFB1
42 urinary system disease 9.7 CCL2 TGFB1 VEGFA
43 respiratory system disease 9.6 CCL2 TGFB1 VEGFA
44 chagas disease 9.6 CCL2 SMAD2 TGFB1
45 interstitial lung disease 9.5 CCL2 TGFB1 VTN
46 pancreatic cancer 9.5 FGF2 SMAD2 TGFB1 TGFB2 VEGFA
47 microvascular complications of diabetes 1 9.5 CCL2 FGF2 GFAP TGFB2 VEGFA VTN
48 ewing sarcoma 9.4 FGF2 GFAP PDGFB TGFB1 TGFB2 VEGFA
49 pulmonary fibrosis, idiopathic 9.4 CCL2 FGF2 PDGFB SMAD2 TGFB1
50 macular degeneration, age-related, 1 9.1 CCL2 FGF2 OPTC PLG RLBP1 VEGFA

Graphical network of the top 20 diseases related to Vitreous Disease:



Diseases related to Vitreous Disease

Symptoms & Phenotypes for Vitreous Disease

MGI Mouse Phenotypes related to Vitreous Disease:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.26 EMP2 FGF2 FN1 GFAP OPTC PDGFB
2 hematopoietic system MP:0005397 10.13 EMP2 FGF2 FN1 PDGFB PLG SMAD2
3 immune system MP:0005387 10.1 CCL2 EMP2 FN1 GFAP PDGFB PLG
4 embryo MP:0005380 10 EMP2 FN1 PDGFB SMAD2 TGFB1 TGFB2
5 integument MP:0010771 9.91 FN1 PDGFB PLG RLBP1 SMAD2 TGFB1
6 muscle MP:0005369 9.87 FGF2 FN1 GFAP PDGFB TGFB1 TGFB2
7 nervous system MP:0003631 9.85 FGF2 FN1 GFAP PDGFB PLG RLBP1
8 neoplasm MP:0002006 9.73 FGF2 FN1 PLG SMAD2 TGFB1 VEGFA
9 reproductive system MP:0005389 9.61 EMP2 FGF2 FN1 PDGFB PLG SMAD2
10 vision/eye MP:0005391 9.32 FGF2 GFAP OPTC PDGFB PLG RLBP1

Drugs & Therapeutics for Vitreous Disease

Drugs for Vitreous Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carboplatin Approved Phase 3,Phase 1 41575-94-4 10339178 38904 498142
2
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
3
Lenograstim Approved, Investigational Phase 3 135968-09-1
4
Etoposide Approved Phase 3 33419-42-0 36462
5
Vincristine Approved, Investigational Phase 3 2068-78-2, 57-22-7 5978
6
Topotecan Approved, Investigational Phase 3 119413-54-6, 123948-87-8 60700
7
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
8
Mesna Approved, Investigational Phase 3 3375-50-6 598
9
Doxil Approved June 1999 Phase 3 31703
10 Anti-Bacterial Agents Phase 3,Phase 1
11 Immunosuppressive Agents Phase 3
12 Topoisomerase Inhibitors Phase 3
13 Antimitotic Agents Phase 3
14 Antineoplastic Agents, Alkylating Phase 3
15 Alkylating Agents Phase 3
16 Anesthetics Phase 3
17 Etoposide phosphate Phase 3
18 Antineoplastic Agents, Phytogenic Phase 3
19 Immunologic Factors Phase 3
20 Antirheumatic Agents Phase 3
21 Antibiotics, Antitubercular Phase 3
22 topoisomerase I inhibitors Phase 3
23
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 1 1177-87-3
24
Dexamethasone Approved, Investigational, Vet_approved Phase 1 50-02-2 5743
25
Neomycin Approved, Vet_approved Phase 1 1404-04-2 8378
26
Polymyxin B Approved, Vet_approved Phase 1 1404-26-8
27 Polymyxins Phase 1
28 Dexamethasone, neomycin, polymyxin B drug combination Phase 1
29 Anti-Infective Agents Phase 1
30 BB 1101 Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of Treatment for Patients With Cancer of the Eye -Retinoblastoma Active, not recruiting NCT00186888 Phase 3 Vincristine, Carboplatin;Vincristine and Topotecan;Vincristine + Carboplatin + Etoposide;vincristine, cyclophosphamide, and doxorubicin;Vincristine, Carboplatin and Etoposide
2 Intravitreal Carboplatin for the Treatment of Participants With Recurrent or Refractory Intraocular Retinoblastoma Recruiting NCT02792036 Phase 1 Carboplatin;Maxitrol®
3 Advanced OCT and Adaptive Optics Imaging in Retinal Disease (The ACAD Study) Recruiting NCT02828215
4 OCT in Rare Chorioretinal Diseases Recruiting NCT02141308

Search NIH Clinical Center for Vitreous Disease

Genetic Tests for Vitreous Disease

Anatomical Context for Vitreous Disease

MalaCards organs/tissues related to Vitreous Disease:

42
Eye, Retina, Endothelial, Skin, Brain, Thyroid

Publications for Vitreous Disease

Articles related to Vitreous Disease:

# Title Authors Year
1
Vitreous Disease in Retinoblastoma: Clinical Findings and Treatment. ( 29034355 )
2017
2
Intravitreal chemotherapy in the management of vitreous disease in retinoblastoma. ( 28106239 )
2017
3
Feasibility and Outcome of Descemet Membrane Endothelial Keratoplasty in Complex Anterior Segment and Vitreous Disease. ( 26382893 )
2015
4
Intravitreal chemotherapy for vitreous disease in retinoblastoma revisited: from prohibition to conditional indications. ( 22694968 )
2012
5
Concurrent vitreous disease may produce abnormal vitreous humour biochemistry and toxicology. ( 12944563 )
2003
6
Advances in the treatment of vitreous disease. ( 7062469 )
1982
7
THE SURGERY OF THE VITREOUS: A preliminary paper dealing with an experimental Investigation into the Surgery of the Vitreous Body with special reference to its application in cases of Detached Retina, Primary Vitreous Disease, Haemorrhage or Traumatic loss of Vitreous. ( 18168883 )
1930

Variations for Vitreous Disease

Expression for Vitreous Disease

Search GEO for disease gene expression data for Vitreous Disease.

Pathways for Vitreous Disease

Pathways related to Vitreous Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.8 CCL2 FGF2 FN1 GFAP PDGFB SMAD2
2
Show member pathways
13.48 CCL2 FGF2 PDGFB SMAD2 TGFB1 TGFB2
3
Show member pathways
13.35 CCL2 FN1 PLG TGFB1 TGFB2 VEGFA
4
Show member pathways
13.31 CCL2 FGF2 FN1 PDGFB TGFB1 VEGFA
5
Show member pathways
13.26 FN1 PDGFB PLG TGFB1 TGFB2 VEGFA
6
Show member pathways
13.02 FGF2 FN1 PDGFB TGFB1 TGFB2
7
Show member pathways
13 CCL2 FGF2 PDGFB TGFB1 TGFB2
8
Show member pathways
12.93 FGF2 FN1 PDGFB VEGFA VTN
9
Show member pathways
12.92 CCL2 FGF2 PDGFB TGFB1 TGFB2 VEGFA
10
Show member pathways
12.82 PDGFB SMAD2 TGFB1 TGFB2 VEGFA
11 12.72 FGF2 PDGFB TGFB1 TGFB2 VEGFA
12 12.67 FGF2 FN1 PDGFB SMAD2 TGFB1 TGFB2
13
Show member pathways
12.54 PDGFB TGFB1 TGFB2 VEGFA
14
Show member pathways
12.54 CCL2 FGF2 FN1 PDGFB PLG
15
Show member pathways
12.51 FGF2 FN1 OPTC PDGFB PLG TGFB1
16
Show member pathways
12.43 FGF2 PDGFB SMAD2 TGFB1 TGFB2
17 12.32 PDGFB SMAD2 TGFB1 TGFB2
18
Show member pathways
12.22 FGF2 PDGFB TGFB1 TGFB2
19
Show member pathways
12.19 FGF2 FN1 SMAD2 VEGFA
20 12.14 SMAD2 TGFB1 TGFB2 VEGFA
21 12.05 CCL2 PDGFB VEGFA
22
Show member pathways
12.04 SMAD2 TGFB1 TGFB2
23 12.03 FGF2 PDGFB TGFB1 VEGFA
24 12.02 FN1 SMAD2 TGFB1
25 12.02 SMAD2 TGFB1 TGFB2 VEGFA
26
Show member pathways
12.01 SMAD2 TGFB1 TGFB2
27
Show member pathways
11.98 CCL2 FGF2 PDGFB SMAD2 TGFB1 TGFB2
28 11.97 CCL2 GFAP TGFB1
29 11.9 FN1 TGFB1 VTN
30 11.85 FN1 TGFB1 TGFB2
31 11.85 SMAD2 TGFB1 TGFB2
32 11.83 SMAD2 TGFB1 TGFB2
33 11.83 CCL2 TGFB1 TGFB2 VEGFA
34 11.82 CCL2 FGF2 FN1 TGFB1 VEGFA
35 11.81 CCL2 FGF2 TGFB1 TGFB2
36 11.8 FGF2 FN1 SMAD2 TGFB1 TGFB2 VEGFA
37 11.74 FGF2 GFAP PDGFB VEGFA
38
Show member pathways
11.71 TGFB1 TGFB2 VTN
39 11.7 CCL2 TGFB1 TGFB2
40 11.69 FGF2 PDGFB TGFB1 TGFB2
41 11.66 SMAD2 TGFB1 TGFB2 VEGFA
42 11.64 FGF2 TGFB1 TGFB2 VEGFA
43 11.63 CCL2 FN1 SMAD2 TGFB1 TGFB2 VEGFA
44 11.62 FN1 PLG VTN
45 11.61 CCL2 FGF2 PDGFB TGFB1
46 11.59 TGFB1 TGFB2 VTN
47
Show member pathways
11.57 SMAD2 TGFB1 TGFB2
48 11.51 CCL2 TGFB1 TGFB2
49 11.5 FN1 PLG VTN
50 11.46 FGF2 PDGFB TGFB1 VEGFA

GO Terms for Vitreous Disease

Cellular components related to Vitreous Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.96 CCL2 FGF2 FN1 IGFBP6 PDGFB PLG
2 cell surface GO:0009986 9.8 EMP2 PDGFB PLG TGFB1 VEGFA
3 extracellular matrix GO:0031012 9.72 FN1 OPTC TGFB1 VEGFA VTN
4 extracellular region GO:0005576 9.7 CCL2 FGF2 FN1 IGFBP6 OPTC PDGFB
5 blood microparticle GO:0072562 9.67 FN1 PLG TGFB1 VTN
6 collagen-containing extracellular matrix GO:0062023 9.63 FN1 PDGFB PLG TGFB1 TGFB2 VTN
7 Golgi lumen GO:0005796 9.61 PDGFB TGFB1 VTN
8 platelet alpha granule lumen GO:0031093 9.1 FN1 PDGFB PLG TGFB1 TGFB2 VEGFA

Biological processes related to Vitreous Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.96 CCL2 FGF2 PDGFB TGFB1
2 heart development GO:0007507 9.96 PDGFB SMAD2 TGFB1 TGFB2
3 MAPK cascade GO:0000165 9.95 CCL2 FGF2 PDGFB TGFB1
4 cytokine-mediated signaling pathway GO:0019221 9.95 CCL2 FGF2 FN1 TGFB1 VEGFA
5 cell migration GO:0016477 9.93 EMP2 TGFB1 TGFB2 VTN
6 regulation of signaling receptor activity GO:0010469 9.93 CCL2 FGF2 PDGFB TGFB1 TGFB2 VEGFA
7 negative regulation of gene expression GO:0010629 9.92 PDGFB SMAD2 TGFB1 TGFB2 VEGFA
8 positive regulation of cell proliferation GO:0008284 9.91 EMP2 FGF2 FN1 PDGFB TGFB1 TGFB2
9 angiogenesis GO:0001525 9.89 CCL2 FGF2 FN1 TGFB2 VEGFA
10 transforming growth factor beta receptor signaling pathway GO:0007179 9.85 SMAD2 TGFB1 TGFB2
11 cell-matrix adhesion GO:0007160 9.85 EMP2 FN1 VTN
12 positive regulation of endothelial cell proliferation GO:0001938 9.83 FGF2 PDGFB VEGFA
13 extracellular matrix organization GO:0030198 9.83 FGF2 FN1 GFAP PDGFB VTN
14 activation of protein kinase activity GO:0032147 9.81 EMP2 PDGFB TGFB2 VEGFA
15 SMAD protein signal transduction GO:0060395 9.8 SMAD2 TGFB1 TGFB2
16 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.78 PDGFB TGFB1 VEGFA VTN
17 positive regulation of fibroblast proliferation GO:0048146 9.77 FN1 PDGFB TGFB1
18 positive chemotaxis GO:0050918 9.76 FGF2 PDGFB VEGFA
19 positive regulation of epithelial to mesenchymal transition GO:0010718 9.75 SMAD2 TGFB1 TGFB2
20 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.73 FGF2 PDGFB TGFB1
21 cell migration involved in sprouting angiogenesis GO:0002042 9.71 FGF2 VEGFA
22 regulation of transforming growth factor beta receptor signaling pathway GO:0017015 9.71 SMAD2 TGFB1
23 positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 9.71 TGFB1 VEGFA
24 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.71 PDGFB TGFB1 TGFB2
25 positive regulation of MAP kinase activity GO:0043406 9.71 FGF2 PDGFB TGFB1 VEGFA
26 positive regulation of smooth muscle cell migration GO:0014911 9.7 PDGFB VTN
27 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.7 VEGFA VTN
28 hyaluronan catabolic process GO:0030214 9.7 FGF2 TGFB1
29 positive regulation of calcium ion import GO:0090280 9.7 CCL2 PDGFB
30 positive regulation of DNA biosynthetic process GO:2000573 9.69 FGF2 PDGFB
31 negative regulation of immune response GO:0050777 9.69 TGFB1 TGFB2
32 positive regulation of chemotaxis GO:0050921 9.69 PDGFB TGFB1
33 secondary palate development GO:0062009 9.68 SMAD2 TGFB2
34 pathway-restricted SMAD protein phosphorylation GO:0060389 9.68 TGFB1 TGFB2
35 response to cholesterol GO:0070723 9.67 SMAD2 TGFB1
36 salivary gland morphogenesis GO:0007435 9.67 TGFB1 TGFB2
37 heart valve morphogenesis GO:0003179 9.65 TGFB1 TGFB2
38 wound healing GO:0042060 9.65 FGF2 FN1 SMAD2 TGFB1 TGFB2
39 paracrine signaling GO:0038001 9.64 FGF2 PDGFB
40 SMAD protein complex assembly GO:0007183 9.64 SMAD2 TGFB1
41 common-partner SMAD protein phosphorylation GO:0007182 9.62 SMAD2 TGFB1
42 interaction with symbiont GO:0051702 9.62 FN1 PLG
43 positive regulation of blood vessel endothelial cell migration GO:0043536 9.62 FGF2 PDGFB TGFB1 VEGFA
44 negative regulation of macrophage cytokine production GO:0010936 9.59 TGFB1 TGFB2
45 regulation of binding GO:0051098 9.57 SMAD2 TGFB1
46 response to wounding GO:0009611 9.55 FN1 GFAP PDGFB TGFB1 TGFB2
47 platelet degranulation GO:0002576 9.43 FN1 PDGFB PLG TGFB1 TGFB2 VEGFA
48 positive regulation of cell division GO:0051781 9.02 FGF2 PDGFB TGFB1 TGFB2 VEGFA
49 protein phosphorylation GO:0006468 10.08 CCL2 PDGFB SMAD2 TGFB1 TGFB2
50 cell proliferation GO:0008283 10.01 EMP2 TGFB1 TGFB2 VTN

Molecular functions related to Vitreous Disease according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 protein heterodimerization activity GO:0046982 9.89 PDGFB SMAD2 TGFB1 TGFB2 VEGFA
2 signaling receptor binding GO:0005102 9.83 CCL2 FN1 IGFBP6 PLG TGFB2
3 extracellular matrix structural constituent GO:0005201 9.73 FN1 OPTC VTN
4 kinase binding GO:0019900 9.71 EMP2 GFAP PLG
5 heparin binding GO:0008201 9.71 FGF2 FN1 VEGFA VTN
6 collagen binding GO:0005518 9.65 FN1 PDGFB VTN
7 platelet-derived growth factor receptor binding GO:0005161 9.55 PDGFB VEGFA
8 cytokine activity GO:0005125 9.55 CCL2 FGF2 TGFB1 TGFB2 VEGFA
9 transforming growth factor beta receptor binding GO:0005160 9.54 SMAD2 TGFB1 TGFB2
10 type I transforming growth factor beta receptor binding GO:0034713 9.51 SMAD2 TGFB1
11 type II transforming growth factor beta receptor binding GO:0005114 9.46 TGFB1 TGFB2
12 chemoattractant activity GO:0042056 9.43 FGF2 PDGFB VEGFA
13 growth factor activity GO:0008083 9.35 FGF2 PDGFB TGFB1 TGFB2 VEGFA
14 type III transforming growth factor beta receptor binding GO:0034714 9.32 TGFB1 TGFB2
15 integrin binding GO:0005178 8.92 EMP2 FGF2 FN1 VTN
16 identical protein binding GO:0042802 10 FN1 GFAP PDGFB TGFB1 VEGFA VTN

Sources for Vitreous Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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