MCID: VTR005
MIFTS: 41

Vitreous Disease

Categories: Eye diseases

Aliases & Classifications for Vitreous Disease

MalaCards integrated aliases for Vitreous Disease:

Name: Vitreous Disease 12 15
Disorder of Vitreous Body 73

Classifications:



External Ids:

Disease Ontology 12 DOID:9720
ICD10 33 H43.3 H43.39
ICD9CM 35 379.24

Summaries for Vitreous Disease

Disease Ontology : 12 An eye and adnexa disease that is located in the vitreous of the eye.

MalaCards based summary : Vitreous Disease, also known as disorder of vitreous body, is related to neovascular glaucoma and angiodysplasia. An important gene associated with Vitreous Disease is TGFB2 (Transforming Growth Factor Beta 2), and among its related pathways/superpathways are Human cytomegalovirus infection and Pathways in cancer. The drugs Carboplatin and Doxorubicin have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and endothelial, and related phenotypes are cardiovascular system and digestive/alimentary

Wikipedia : 76 The vitreous body is the clear gel that fills the space between the lens and the retina of the eyeball... more...

Related Diseases for Vitreous Disease

Diseases related to Vitreous Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)
# Related Disease Score Top Affiliating Genes
1 neovascular glaucoma 10.2 TGFB2 VEGFA
2 angiodysplasia 10.2 FGF2 VEGFA
3 radiation proctitis 10.2 FGF2 VEGFA
4 cornea cancer 10.2 FGF2 GFAP
5 microcystic meningioma 10.2 GFAP VEGFA
6 blood group, globoside system 10.1 PLG VEGFA
7 endometrial adenocarcinoma 10.1 EMP2 FGF2 VEGFA
8 eye degenerative disease 10.1 KCNJ13 VEGFA
9 chronic myocardial ischemia 10.1 FGF2 PLG VEGFA
10 corneal neovascularization 10.1 FGF2 PLG VEGFA
11 vitreous detachment 10.1 OPTC PLG VEGFA
12 angiomatous meningioma 10.1 FGF2 GFAP VEGFA
13 endophthalmitis 10.1 PLG VEGFA
14 cerebral ventricle cancer 10.1 GFAP KCNJ13
15 chronic ulcer of skin 10.1 FGF2 PDGFB
16 connective tissue cancer 10.1 FGF2 PDGFB VEGFA
17 brown-sequard syndrome 10.1 GFAP PLG
18 kaposi sarcoma 10.1 FGF2 PDGFB VEGFA
19 septicemic plague 10.1 PLG VTN
20 meningioma, familial 10.0 GFAP PDGFB VEGFA
21 preretinal fibrosis 10.0 GFAP RLBP1 TGFB2 VEGFA
22 papilloma of choroid plexus 10.0 GFAP KCNJ13
23 diabetic foot ulcers 10.0 CCL2 PDGFB
24 macular holes 10.0 CCL2 TGFB2 VEGFA
25 retinoblastoma 9.9
26 diabetic macular edema 9.9 CCL2 FGF2 VEGFA
27 brain cancer 9.9 FGF2 GFAP PDGFB VEGFA
28 retinal vascular occlusion 9.9 CCL2 PLG VEGFA
29 retinal vascular disease 9.9 CCL2 PLG VEGFA
30 arteries, anomalies of 9.9 CCL2 PLG VEGFA
31 retinal detachment 9.9 GFAP KCNJ13 PDGFB VEGFA
32 choroid plexus cancer 9.9 GFAP KCNJ13
33 macular retinal edema 9.9 CCL2 VEGFA
34 ewing sarcoma 9.8 FGF2 GFAP PDGFB TGFB2 VEGFA
35 central nervous system disease 9.8 CCL2 GFAP PLG
36 vascular disease 9.8 CCL2 FGF2 PLG VEGFA
37 nervous system disease 9.8 CCL2 GFAP PLG VEGFA
38 pulmonary fibrosis, idiopathic 9.8 CCL2 FGF2 PDGFB SMAD2
39 vitreoretinopathy, neovascular inflammatory 9.6 CCL2 FGF2 GFAP TGFB2 VTN
40 microvascular complications of diabetes 1 9.5 CCL2 FGF2 GFAP TGFB2 VEGFA VTN
41 macular degeneration, age-related, 1 9.4 CCL2 FGF2 OPTC PLG RLBP1 VEGFA

Graphical network of the top 20 diseases related to Vitreous Disease:



Diseases related to Vitreous Disease

Symptoms & Phenotypes for Vitreous Disease

MGI Mouse Phenotypes related to Vitreous Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.02 EMP2 FGF2 GFAP OPTC PDGFB PLG
2 digestive/alimentary MP:0005381 9.73 GFAP KCNJ13 PLG SMAD2 TGFB2 VEGFA
3 reproductive system MP:0005389 9.7 EMP2 FGF2 PDGFB PLG SMAD2 TGFB2
4 respiratory system MP:0005388 9.43 KCNJ13 PDGFB PLG SMAD2 TGFB2 VEGFA
5 vision/eye MP:0005391 9.28 FGF2 GFAP OPTC PDGFB PLG RLBP1

Drugs & Therapeutics for Vitreous Disease

Drugs for Vitreous Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carboplatin Approved Phase 3,Phase 1 41575-94-4 10339178 38904 498142
2
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
3
Vincristine Approved, Investigational Phase 3 57-22-7, 2068-78-2 5978
4
Cyclophosphamide Approved, Investigational Phase 3 6055-19-2, 50-18-0 2907
5
Topotecan Approved, Investigational Phase 3 123948-87-8, 119413-54-6 60700
6
Mesna Approved, Investigational Phase 3 3375-50-6 598
7
Etoposide Approved Phase 3 33419-42-0 36462
8
Doxil Approved June 1999 Phase 3 31703
9 Anti-Bacterial Agents Phase 3,Phase 1
10 Topoisomerase Inhibitors Phase 3
11 Anesthetics Phase 3
12 topoisomerase I inhibitors Phase 3
13 Antineoplastic Agents, Phytogenic Phase 3
14 Alkylating Agents Phase 3
15 Antibiotics, Antitubercular Phase 3
16 Etoposide phosphate Phase 3
17 Antineoplastic Agents, Alkylating Phase 3
18 Antirheumatic Agents Phase 3
19 Antimitotic Agents Phase 3
20 Immunosuppressive Agents Phase 3
21 Immunologic Factors Phase 3
22
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 1 1177-87-3
23
Neomycin Approved, Vet_approved Phase 1 1404-04-2 8378
24
Dexamethasone Approved, Investigational, Vet_approved Phase 1 50-02-2 5743
25 Polymyxin B Phase 1
26 Polymyxins Phase 1
27 Dexamethasone, neomycin, polymyxin B drug combination Phase 1
28 BB 1101 Phase 1
29 Anti-Infective Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of Treatment for Patients With Cancer of the Eye -Retinoblastoma Active, not recruiting NCT00186888 Phase 3 Vincristine, Carboplatin;Vincristine + Topotecan;Vincristine + Carboplatin + Etoposide;Vincristine + Cyclophosphamide + Doxorubicin;Vincristine+Carboplatin+Etoposide
2 Intravitreal Carboplatin for the Treatment of Participants With Recurrent or Refractory Intraocular Retinoblastoma Recruiting NCT02792036 Phase 1 Carboplatin;Maxitrol®
3 Advanced OCT and Adaptive Optics Imaging in Retinal Disease (The ACAD Study) Recruiting NCT02828215
4 OCT in Rare Chorioretinal Diseases Recruiting NCT02141308

Search NIH Clinical Center for Vitreous Disease

Genetic Tests for Vitreous Disease

Anatomical Context for Vitreous Disease

MalaCards organs/tissues related to Vitreous Disease:

41
Eye, Retina, Endothelial, Skin, Brain

Publications for Vitreous Disease

Articles related to Vitreous Disease:

# Title Authors Year
1
Vitreous Disease in Retinoblastoma: Clinical Findings and Treatment. ( 29034355 )
2017
2
Intravitreal chemotherapy in the management of vitreous disease in retinoblastoma. ( 28106239 )
2017
3
Feasibility and Outcome of Descemet Membrane Endothelial Keratoplasty in Complex Anterior Segment and Vitreous Disease. ( 26382893 )
2015
4
Intravitreal chemotherapy for vitreous disease in retinoblastoma revisited: from prohibition to conditional indications. ( 22694968 )
2012
5
Concurrent vitreous disease may produce abnormal vitreous humour biochemistry and toxicology. ( 12944563 )
2003
6
Advances in the treatment of vitreous disease. ( 7062469 )
1982
7
THE SURGERY OF THE VITREOUS: A preliminary paper dealing with an experimental Investigation into the Surgery of the Vitreous Body with special reference to its application in cases of Detached Retina, Primary Vitreous Disease, Haemorrhage or Traumatic loss of Vitreous. ( 18168883 )
1930

Variations for Vitreous Disease

Expression for Vitreous Disease

Search GEO for disease gene expression data for Vitreous Disease.

Pathways for Vitreous Disease

Pathways related to Vitreous Disease according to GeneCards Suite gene sharing:

(show all 30)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.89 CCL2 FGF2 PDGFB TGFB2 VEGFA
2 12.67 FGF2 PDGFB SMAD2 TGFB2 VEGFA
3 12.62 FGF2 PDGFB TGFB2 VEGFA
4
Show member pathways
12.43 CCL2 FGF2 PDGFB PLG
5
Show member pathways
12.39 FGF2 OPTC PDGFB PLG TGFB2 VTN
6
Show member pathways
12.31 FGF2 PDGFB SMAD2 TGFB2
7 12.03 SMAD2 TGFB2 VEGFA
8 11.94 CCL2 PDGFB VEGFA
9 11.92 FGF2 PDGFB VEGFA
10 11.9 SMAD2 TGFB2 VEGFA
11
Show member pathways
11.84 CCL2 FGF2 PDGFB SMAD2 TGFB2
12 11.83 CCL2 FGF2 VEGFA
13 11.71 CCL2 TGFB2 VEGFA
14 11.7 CCL2 FGF2 TGFB2
15 11.66 FGF2 SMAD2 TGFB2 VEGFA VTN
16 11.62 CCL2 SMAD2 TGFB2 VEGFA
17 11.55 SMAD2 TGFB2 VEGFA
18
Show member pathways
11.54 FGF2 PDGFB VTN
19 11.51 FGF2 TGFB2 VEGFA
20 11.49 CCL2 FGF2 PDGFB
21 11.35 FGF2 PDGFB VEGFA
22 11.35 FGF2 GFAP PDGFB VEGFA
23 11.32 FGF2 VEGFA VTN
24 11.26 FGF2 PDGFB VEGFA
25 11 FGF2 SMAD2 VEGFA
26 10.95 IGFBP6 PLG
27 10.92 FGF2 PDGFB VEGFA
28 10.89 CCL2 VEGFA
29 10.86 CCL2 FGF2 GFAP PDGFB TGFB2
30 10.61 FGF2 PLG TGFB2 VEGFA

GO Terms for Vitreous Disease

Cellular components related to Vitreous Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.76 CCL2 FGF2 IGFBP6 PDGFB PLG TGFB2
2 extracellular region GO:0005576 9.61 CCL2 FGF2 IGFBP6 OPTC PDGFB PLG
3 collagen-containing extracellular matrix GO:0062023 9.56 PDGFB PLG TGFB2 VTN
4 platelet alpha granule lumen GO:0031093 8.92 PDGFB PLG TGFB2 VEGFA

Biological processes related to Vitreous Disease according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.92 IGFBP6 PLG SMAD2 TGFB2
2 positive regulation of cell proliferation GO:0008284 9.92 EMP2 FGF2 PDGFB TGFB2 VEGFA
3 negative regulation of gene expression GO:0010629 9.84 PDGFB SMAD2 TGFB2 VEGFA
4 angiogenesis GO:0001525 9.78 CCL2 FGF2 TGFB2 VEGFA
5 regulation of signaling receptor activity GO:0010469 9.77 CCL2 FGF2 PDGFB TGFB2 VEGFA
6 wound healing GO:0042060 9.73 FGF2 SMAD2 TGFB2
7 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.72 PDGFB VEGFA VTN
8 extracellular matrix organization GO:0030198 9.71 FGF2 GFAP PDGFB VTN
9 response to wounding GO:0009611 9.69 GFAP PDGFB TGFB2
10 positive regulation of endothelial cell proliferation GO:0001938 9.67 FGF2 PDGFB VEGFA
11 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.63 PDGFB TGFB2
12 positive regulation of sprouting angiogenesis GO:1903672 9.62 FGF2 VEGFA
13 positive regulation of protein autophosphorylation GO:0031954 9.61 PDGFB VEGFA
14 cell migration involved in sprouting angiogenesis GO:0002042 9.61 FGF2 VEGFA
15 positive regulation of MAP kinase activity GO:0043406 9.61 FGF2 PDGFB VEGFA
16 positive regulation of smooth muscle cell migration GO:0014911 9.6 PDGFB VTN
17 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.59 VEGFA VTN
18 positive regulation of calcium ion import GO:0090280 9.58 CCL2 PDGFB
19 positive regulation of DNA biosynthetic process GO:2000573 9.58 FGF2 PDGFB
20 secondary palate development GO:0062009 9.57 SMAD2 TGFB2
21 positive regulation of blood vessel endothelial cell migration GO:0043536 9.5 FGF2 PDGFB VEGFA
22 paracrine signaling GO:0038001 9.46 FGF2 PDGFB
23 platelet degranulation GO:0002576 9.46 PDGFB PLG TGFB2 VEGFA
24 positive chemotaxis GO:0050918 9.43 FGF2 PDGFB VEGFA
25 activation of protein kinase activity GO:0032147 9.26 EMP2 PDGFB TGFB2 VEGFA
26 positive regulation of cell division GO:0051781 8.92 FGF2 PDGFB TGFB2 VEGFA

Molecular functions related to Vitreous Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.71 CCL2 IGFBP6 PLG TGFB2
2 heparin binding GO:0008201 9.61 FGF2 VEGFA VTN
3 cytokine activity GO:0005125 9.56 CCL2 FGF2 TGFB2 VEGFA
4 kinase binding GO:0019900 9.5 EMP2 GFAP PLG
5 growth factor activity GO:0008083 9.46 FGF2 PDGFB TGFB2 VEGFA
6 platelet-derived growth factor receptor binding GO:0005161 9.37 PDGFB VEGFA
7 chemoattractant activity GO:0042056 9.13 FGF2 PDGFB VEGFA
8 integrin binding GO:0005178 8.92 EMP2 FGF2 GFAP VTN

Sources for Vitreous Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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