MCID: VTR005
MIFTS: 41

Vitreous Disease

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Vitreous Disease

MalaCards integrated aliases for Vitreous Disease:

Name: Vitreous Disease 12 15
Disorder of Vitreous Body 70

Classifications:



External Ids:

Disease Ontology 12 DOID:9720
ICD9CM 34 379.24
SNOMED-CT 67 194154006
UMLS 70 C0029872 C0155365

Summaries for Vitreous Disease

Disease Ontology : 12 An eye and adnexa disease that is located in the vitreous of the eye.

MalaCards based summary : Vitreous Disease, also known as disorder of vitreous body, is related to persistent hyperplastic primary vitreous and vitreoretinopathy, neovascular inflammatory. An important gene associated with Vitreous Disease is CAPN5 (Calpain 5), and among its related pathways/superpathways are ERK Signaling and Pathways in cancer. The drugs Mesna and Topotecan have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and endothelial, and related phenotypes are cardiovascular system and cellular

Wikipedia : 73 The vitreous body (vitreous meaning "glass-like", from Latin vitreus, equivalent to vitr(um) glass +... more...

Related Diseases for Vitreous Disease

Diseases related to Vitreous Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 200)
# Related Disease Score Top Affiliating Genes
1 persistent hyperplastic primary vitreous 31.5 VEGFA TGFB2 PAX6 OTX2 NDP
2 vitreoretinopathy, neovascular inflammatory 30.8 VEGFA TGFB2 RPE65 RLBP1 GFAP FN1
3 vitreous abscess 10.9
4 upper lip cancer 10.4 TGFB2 FGF2
5 steroid-induced glaucoma 10.4 TGFB2 FN1 CRYAA
6 pauci-immune glomerulonephritis 10.4 SMAD2 CCN2
7 vitreoretinal dystrophy 10.4 OPTC CRYAA CAPN5
8 osteosclerotic myeloma 10.4 VEGFA IL6
9 branch retinal artery occlusion 10.4 VEGFA PLG CRYAA
10 central retinal artery occlusion 10.4 VEGFA PLG CRYAA
11 patterned macular dystrophy 10.4 VEGFA RHO
12 kuhnt-junius degeneration 10.4 VEGFA PLG CRYAA
13 autoimmune disease of eyes, ear, nose and throat 10.4 IL6 CRYAA CAPN5
14 microphthalmia, syndromic 8 10.4 PAX6 OTX2
15 exotropia 10.4 RPE65 PAX6 CRYAA
16 fryns microphthalmia syndrome 10.4 PAX6 OTX2
17 rubeosis iridis 10.3 VEGFA PLG
18 solar retinopathy 10.3 RLBP1 RHO
19 ulcer of lower limbs 10.3 VEGFA IL6 FGF2
20 trachoma 10.3 VEGFA IL6 CCN2
21 capillary disease 10.3 VEGFA IL6 FGF2
22 poems syndrome 10.3 VEGFA IL6 FGF2
23 intussusception 10.3 VEGFA IL6 FGF2
24 necrotizing fasciitis 10.3 PLG IL6 FN1
25 macular degeneration, age-related, 7 10.3 RPE65 PAX6 OTX2
26 ischemic bone disease 10.3 VEGFA IL6 FGF2
27 yemenite deaf-blind hypopigmentation syndrome 10.3 VEGFA RPE65 RHO
28 hepatic veno-occlusive disease 10.3 VEGFA PLG FGF2
29 hereditary retinal dystrophy 10.3 RPE65 RHO CRYAA
30 endocardium disease 10.3 PLG IL6 FN1
31 leber congenital amaurosis 2 10.3 RPE65 RHO CRYAA
32 choroid disease 10.3 VEGFA RPE65 RHO
33 scotoma 10.3 VEGFA RPE65 RHO
34 iris disease 10.3 PAX6 OTX2 CRYAA
35 vascular cancer 10.3 VEGFA PLG FGF2
36 erysipeloid 10.3 PLG FN1
37 radiation proctitis 10.3 VEGFA FGF2
38 pericardial effusion 10.3 VEGFA IL6 FGF2
39 pulmonary artery disease 10.3 VEGFA PLG IL6
40 fuchs' heterochromic uveitis 10.3 TGFB2 IL6 CCL2
41 vitreoretinopathy 10.3 NDP IL6 CAPN5
42 color blindness 10.3 RPE65 RHO CRYAA
43 hepatic vascular disease 10.3 VEGFA PLG IL6
44 syndromic microphthalmia 10.3 PAX6 OTX2 CRYAA
45 mckusick-kaufman syndrome 10.3 FN1 CCN2 CCL2
46 esotropia 10.3 PAX6 OTX2 CRYAA
47 gyrate atrophy of choroid and retina 10.3 RPE65 RLBP1 RHO
48 gingival fibromatosis 10.3 IL6 FN1 CCN2
49 amblyopia 10.3 PAX6 OTX2 CRYAA
50 proliferative glomerulonephritis 10.3 IL6 CCN2 CCL2

Graphical network of the top 20 diseases related to Vitreous Disease:



Diseases related to Vitreous Disease

Symptoms & Phenotypes for Vitreous Disease

MGI Mouse Phenotypes related to Vitreous Disease:

46 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.42 CCN2 FGF2 FN1 GFAP IL6 NDP
2 cellular MP:0005384 10.35 CCN2 FGF2 FN1 GFAP IL6 OTX2
3 homeostasis/metabolism MP:0005376 10.35 CCN2 FGF2 FN1 GFAP IL6 OTX2
4 growth/size/body region MP:0005378 10.31 CAPN5 CCN2 FN1 GFAP IL6 OTX2
5 nervous system MP:0003631 10.24 FGF2 FN1 GFAP IL6 NDP OTX2
6 immune system MP:0005387 10.23 CAPN5 CCL2 FN1 GFAP IL6 PAX6
7 digestive/alimentary MP:0005381 10.16 CCN2 GFAP IL6 OTX2 PAX6 PLG
8 craniofacial MP:0005382 10.13 CCN2 FN1 OTX2 PAX6 RLBP1 SMAD2
9 muscle MP:0005369 10.03 FGF2 FN1 GFAP IL6 OTX2 PAX6
10 reproductive system MP:0005389 9.96 FGF2 FN1 IL6 NDP OTX2 PAX6
11 neoplasm MP:0002006 9.95 FGF2 FN1 IL6 PAX6 PLG SMAD2
12 pigmentation MP:0001186 9.8 NDP OTX2 PAX6 RHO RLBP1 RPE65
13 respiratory system MP:0005388 9.76 CCN2 IL6 OTX2 PAX6 PLG SMAD2
14 skeleton MP:0005390 9.7 CCN2 FGF2 FN1 IL6 NDP OTX2
15 vision/eye MP:0005391 9.5 CCN2 FGF2 GFAP IL6 NDP OPTC

Drugs & Therapeutics for Vitreous Disease

Drugs for Vitreous Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mesna Approved, Investigational Phase 3 3375-50-6 598
2
Topotecan Approved, Investigational Phase 3 119413-54-6, 123948-87-8 60700
3
Vincristine Approved, Investigational Phase 3 2068-78-2, 57-22-7 5978
4
Etoposide Approved Phase 3 33419-42-0 36462
5
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
6
Lenograstim Approved, Investigational Phase 3 135968-09-1
7
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
8
Carboplatin Approved Phase 3 41575-94-4 10339178 498142 38904
9
Liposomal doxorubicin Phase 3 31703
10 Tubulin Modulators Phase 3
11 Antirheumatic Agents Phase 3
12 topoisomerase I inhibitors Phase 3
13 Immunosuppressive Agents Phase 3
14 Etoposide phosphate Phase 3
15 Anesthetics Phase 3
16 Antimitotic Agents Phase 3
17 Alkylating Agents Phase 3
18 Antibiotics, Antitubercular Phase 3
19 Anti-Bacterial Agents Phase 3
20 Immunologic Factors Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Protocol for the Study and Treatment of Patients With Intraocular Retinoblastoma Active, not recruiting NCT00186888 Phase 3 Vincristine, Carboplatin;Vincristine and Topotecan;Vincristine + Carboplatin + Etoposide;vincristine, cyclophosphamide, and doxorubicin;Vincristine, Carboplatin and Etoposide
2 A Prospective Study to Evaluate Swept-Source OCT and Adaptive Optics Imaging of Diseases of the Vitreous, Retina and Choroid Completed NCT02828215

Search NIH Clinical Center for Vitreous Disease

Genetic Tests for Vitreous Disease

Anatomical Context for Vitreous Disease

MalaCards organs/tissues related to Vitreous Disease:

40
Eye, Retina, Endothelial, Bone, Brain, Kidney, Breast

Publications for Vitreous Disease

Articles related to Vitreous Disease:

(show all 23)
# Title Authors PMID Year
1
Comparison of intravitreal melphalan with and without topotecan in the management of vitreous disease in retinoblastoma. 61
32447585 2020
2
Intravitreal chemotherapy in retinoblastoma: expanded use beyond intravitreal seeds. 61
29875233 2019
3
Mapping research trends of retinal vein occlusion from 2009 to 2018: a bibliometric analysis. 61
31528507 2019
4
Vitreous Disease in Retinoblastoma: Clinical Findings and Treatment. 61
29034355 2017
5
Intravitreal chemotherapy in the management of vitreous disease in retinoblastoma. 61
28106239 2017
6
Classification of Vitreous Seeds in Retinoblastoma: Correlations with Patient, Tumor, and Treatment Characteristics. 61
27030103 2016
7
Feasibility and Outcome of Descemet Membrane Endothelial Keratoplasty in Complex Anterior Segment and Vitreous Disease. 61
26382893 2015
8
Ultrasound-based quantification of vitreous floaters correlates with contrast sensitivity and quality of life. 61
25613948 2015
9
Intravitreal chemotherapy for vitreous seeding in retinoblastoma: Recent advances and perspectives. 61
24227979 2013
10
Profiling safety of intravitreal injections for retinoblastoma using an anti-reflux procedure and sterilisation of the needle track. 61
22368262 2012
11
Intravitreal chemotherapy for vitreous disease in retinoblastoma revisited: from prohibition to conditional indications. 61
22694968 2012
12
[Effects of implementing clinical pathways for the care of patients undergoing ophthalmic surgery for cataract, glaucoma, and vitreoretinal disorder]. 61
16491870 2006
13
Lack of activity of oral etoposide for relapsed intraocular retinoblastoma. 61
15255111 2004
14
Concurrent vitreous disease may produce abnormal vitreous humour biochemistry and toxicology. 61
12944563 2003
15
A phase I/II study of subconjunctival carboplatin for intraocular retinoblastoma. 61
10519590 1999
16
Cutaneous melanoma metastatic to the vitreous cavity. 61
9544631 1998
17
Fluorescein blue, light-assisted capsulorhexis for mature or hypermature cataract. 61
9494894 1998
18
[Type I like collagen appeared in vitreous disease]. 61
3195393 1988
19
The significance of the pars plana exudate in pars planitis. 61
3578463 1987
20
Advances in the treatment of vitreous disease. 61
7062469 1982
21
Pars plana vitrectomy for asteroid hyalosis. 61
7348845 1981
22
Vitrectomy: a new challenge for the anesthesiologist. 61
1167762 1975
23
THE SURGERY OF THE VITREOUS: A preliminary paper dealing with an experimental Investigation into the Surgery of the Vitreous Body with special reference to its application in cases of Detached Retina, Primary Vitreous Disease, Haemorrhage or Traumatic loss of Vitreous. 61
18168883 1930

Variations for Vitreous Disease

Expression for Vitreous Disease

Search GEO for disease gene expression data for Vitreous Disease.

Pathways for Vitreous Disease

Pathways related to Vitreous Disease according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.73 VEGFA TGFB2 SMAD2 PAX6 IL6 FN1
2 12.75 VEGFA TGFB2 SMAD2 IL6 FN1 FGF2
3
Show member pathways
12.63 TGFB2 PLG OPTC FN1 FGF2 CAPN5
4
Show member pathways
12.5 PLG IL6 FN1 FGF2 CCL2
5
Show member pathways
12.31 TGFB2 PAX6 IL6 FGF2 CCN2
6 12.17 VEGFA TGFB2 SMAD2 FN1 FGF2
7 12.11 VEGFA TGFB2 SMAD2 IL6
8 11.79 TGFB2 IL6 FN1 FGF2
9 11.78 VEGFA PAX6 OTX2 IL6 FGF2
10
Show member pathways
11.77 TGFB2 SMAD2 IL6
11 11.75 TGFB2 FGF2 CCL2
12 11.75 VEGFA TGFB2 IL6 CCL2
13 11.63 VEGFA PAX6 GFAP FGF2
14 11.61 VEGFA IL6 FN1 FGF2 CCL2
15 11.6 VEGFA TGFB2 FGF2
16
Show member pathways
11.52 RPE65 RLBP1 RHO
17 11.5 IL6 FGF2 CCN2 CCL2
18 11.47 TGFB2 IL6 CCL2
19 11.44 VEGFA IL6 FGF2
20 11.41 VEGFA FN1 FGF2
21 11.3 PLG IL6 FN1 CCN2
22 11.2 PLG FN1 FGF2
23 11.12 VEGFA SMAD2 FGF2
24 11.1 VEGFA TGFB2 SMAD2 IL6 FN1 CCL2
25 11.04 VEGFA TGFB2 PLG FN1 FGF2
26 10.82 TGFB2 IL6 GFAP FN1 FGF2 CCN2
27 10.7 TGFB2 IL6

GO Terms for Vitreous Disease

Cellular components related to Vitreous Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.91 VEGFA TGFB2 PLG NDP IL6 FN1
2 extracellular region GO:0005576 9.85 VEGFA TGFB2 PLG OPTC NDP IL6
3 collagen-containing extracellular matrix GO:0062023 9.72 TGFB2 PLG NDP FN1 CCN2
4 cell body GO:0044297 9.54 RPE65 RLBP1 GFAP
5 extracellular matrix GO:0031012 9.35 VEGFA OPTC NDP FN1 CCN2
6 platelet alpha granule lumen GO:0031093 8.92 VEGFA TGFB2 PLG FN1

Biological processes related to Vitreous Disease according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 10.04 SMAD2 PAX6 OTX2 NDP IL6 FGF2
2 negative regulation of cell proliferation GO:0008285 10 TGFB2 SMAD2 PLG PAX6 IL6
3 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.91 VEGFA FGF2 CCN2 CCL2
4 negative regulation of gene expression GO:0010629 9.91 VEGFA TGFB2 SMAD2 FGF2 CCN2
5 cytokine-mediated signaling pathway GO:0019221 9.89 VEGFA IL6 FN1 FGF2 CCL2
6 angiogenesis GO:0001525 9.8 VEGFA FN1 FGF2 CCN2 CCL2
7 positive regulation of cell proliferation GO:0008284 9.8 VEGFA TJP1 TGFB2 IL6 FN1 FGF2
8 retina development in camera-type eye GO:0060041 9.78 RPE65 RHO PAX6
9 platelet degranulation GO:0002576 9.78 VEGFA TGFB2 PLG FN1
10 retinoid metabolic process GO:0001523 9.76 RPE65 RLBP1 RHO
11 wound healing GO:0042060 9.73 TGFB2 SMAD2 FN1 FGF2
12 positive regulation of cell division GO:0051781 9.72 VEGFA TGFB2 FGF2
13 positive regulation of epithelial to mesenchymal transition GO:0010718 9.71 TGFB2 SMAD2 IL6
14 positive regulation of gene expression GO:0010628 9.7 VEGFA SMAD2 PAX6 IL6 FN1 FGF2
15 lung development GO:0030324 9.67 VEGFA SMAD2 FGF2 CCN2
16 positive regulation of sprouting angiogenesis GO:1903672 9.63 VEGFA TJP1 FGF2
17 negative regulation of cell-cell adhesion mediated by cadherin GO:2000048 9.62 VEGFA PLG
18 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.62 VEGFA TGFB2 FN1 FGF2
19 salivary gland morphogenesis GO:0007435 9.59 TGFB2 PAX6
20 vitamin A metabolic process GO:0006776 9.58 RPE65 RLBP1
21 interaction with symbiont GO:0051702 9.56 PLG FN1
22 positive regulation of epithelial tube formation GO:1905278 9.52 VEGFA FGF2
23 visual perception GO:0007601 9.43 RPE65 RLBP1 RHO PAX6 NDP CRYAA
24 response to wounding GO:0009611 9.02 TGFB2 PAX6 GFAP FN1 CCN2

Molecular functions related to Vitreous Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 9.56 VEGFA FN1 FGF2 CCN2
2 integrin binding GO:0005178 9.46 GFAP FN1 FGF2 CCN2
3 co-SMAD binding GO:0070410 9.37 SMAD2 PAX6
4 growth factor activity GO:0008083 9.35 VEGFA TGFB2 IL6 FGF2 CCN2
5 11-cis retinal binding GO:0005502 9.32 RLBP1 RHO
6 cytokine activity GO:0005125 9.1 VEGFA TGFB2 NDP IL6 FGF2 CCL2

Sources for Vitreous Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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