MCID: VTR002
MIFTS: 31

Vitreous Syneresis

Categories: Neuronal diseases

Aliases & Classifications for Vitreous Syneresis

MalaCards integrated aliases for Vitreous Syneresis:

Name: Vitreous Syneresis 12 15
Vitreous Degeneration 12 54 70

Classifications:



External Ids:

Disease Ontology 12 DOID:11816
ICD9CM 34 379.21
SNOMED-CT 67 60189009
ICD10 32 H43.81
UMLS 70 C0155366

Summaries for Vitreous Syneresis

MalaCards based summary : Vitreous Syneresis, also known as vitreous degeneration, is related to vitreous detachment and macular holes. An important gene associated with Vitreous Syneresis is COL2A1 (Collagen Type II Alpha 1 Chain), and among its related pathways/superpathways are ERK Signaling and Integrin Pathway. Affiliated tissues include bone, eye and retina, and related phenotypes are hearing/vestibular/ear and limbs/digits/tail

Related Diseases for Vitreous Syneresis

Diseases related to Vitreous Syneresis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Related Disease Score Top Affiliating Genes
1 vitreous detachment 30.2 OPTC CYLC1 COL2A1
2 macular holes 29.5 RS1 OPTC
3 cataract 28.9 VCAN KCNJ13 COL9A1 COL2A1 COL11A1
4 retinal detachment 28.8 RS1 KCNJ13 COL9A3 COL9A2 COL9A1 COL2A1
5 myopia 28.3 VCAN OPTC COL9A2 COL9A1 COL2A1 COL11A2
6 vitreoretinal degeneration, snowflake type 11.0
7 back pain 10.2 COL9A3 COL9A2
8 scheuermann disease 10.2 COL9A3 COL2A1
9 stickler syndrome, type i 10.1 COL9A2 COL2A1 COL11A1
10 metatropic dysplasia 10.1 COL2A1 COL11A2
11 bone deterioration disease 10.1 COL9A3 COL9A2 COL2A1
12 kohler's disease 10.1 COL2A1 COL11A2 COL11A1
13 bone structure disease 10.1 COL9A3 COL9A2 COL2A1
14 vitreous disease 10.1 OPTC COL2A1
15 intervertebral disc disease 10.0 COL9A3 COL9A2 COL11A1
16 cleft soft palate 10.0 COL11A2 COL11A1
17 schneckenbecken dysplasia 10.0 COL11A2 COL11A1
18 hypochondrogenesis 10.0 COL9A2 COL9A1 COL2A1
19 multiple epiphyseal dysplasia, autosomal dominant 10.0 COL9A3 COL9A2 COL9A1
20 epiphyseal dysplasia, multiple, 6 10.0 COL9A3 COL9A2 COL9A1
21 epiphyseal dysplasia, multiple, 5 10.0 COL9A3 COL9A2 COL9A1
22 epiphyseal dysplasia, multiple, 3 10.0 COL9A3 COL9A2 COL9A1
23 uveitis 10.0
24 phacoanaphylactic uveitis 10.0
25 epiphyseal dysplasia, multiple, 2 10.0 COL9A3 COL9A2 COL9A1
26 achondrogenesis, type ib 10.0 COL9A3 COL9A2 COL9A1
27 epiphyseal dysplasia, multiple, 1 10.0 COL9A3 COL9A2 COL9A1
28 macroglossia 10.0 COL9A1 COL2A1 COL11A1
29 atelosteogenesis 10.0 COL9A3 COL9A2 COL9A1
30 epiphyseal dysplasia, multiple, 4 10.0 COL9A3 COL9A2 COL9A1
31 osteochondritis dissecans 10.0 COL9A3 COL9A2 COL9A1
32 wagner syndrome 9.9 VCAN COL2A1
33 retinal lattice degeneration 9.9 CYLC2 CYLC1 COL9A3 COL2A1
34 osteochondrosis 9.9 COL9A3 COL9A2 COL9A1 COL2A1
35 diastrophic dysplasia 9.9 COL9A3 COL9A2 COL9A1 COL2A1
36 pseudoachondroplasia 9.9 COL9A3 COL9A2 COL9A1 COL2A1
37 retinitis pigmentosa 9.8
38 neuroretinitis 9.8
39 lens subluxation 9.8
40 retinitis 9.8
41 eye disease 9.8
42 campomelic dysplasia 9.8 COL9A2 COL9A1 COL2A1 COL11A2
43 otospondylomegaepiphyseal dysplasia, autosomal dominant 9.8 COL9A1 COL2A1 COL11A2 COL11A1
44 achondrogenesis, type ii 9.8 COL9A1 COL2A1 COL11A2 COL11A1
45 orofacial cleft 9.7 COL9A1 COL2A1 COL11A2 COL11A1
46 spondyloepiphyseal dysplasia congenita 9.7 COL9A3 COL9A2 COL9A1 COL2A1 COL11A2
47 multiple epiphyseal dysplasia due to collagen 9 anomaly 9.7 SMAP2 COL9A3 COL9A2 COL9A1
48 bone development disease 9.7 COL9A3 COL9A2 COL9A1 COL2A1 COL11A2
49 otospondylomegaepiphyseal dysplasia, autosomal recessive 9.7 COL9A2 COL9A1 COL2A1 COL11A2 COL11A1
50 autosomal recessive stickler syndrome 9.7 COL9A3 COL9A2 COL9A1 COL11A2 COL11A1

Graphical network of the top 20 diseases related to Vitreous Syneresis:



Diseases related to Vitreous Syneresis

Symptoms & Phenotypes for Vitreous Syneresis

MGI Mouse Phenotypes related to Vitreous Syneresis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hearing/vestibular/ear MP:0005377 9.63 COL11A1 COL11A2 COL2A1 COL9A1 COL9A2 COL9A3
2 limbs/digits/tail MP:0005371 9.35 COL11A1 COL2A1 COL9A1 COL9A2 VCAN
3 skeleton MP:0005390 9.17 COL11A1 COL11A2 COL2A1 COL9A1 COL9A2 KCNJ13

Drugs & Therapeutics for Vitreous Syneresis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Incidence of Complete Posterior Vitreous Degeneration After Phacoemulsification Not yet recruiting NCT04727398

Search NIH Clinical Center for Vitreous Syneresis

Genetic Tests for Vitreous Syneresis

Anatomical Context for Vitreous Syneresis

MalaCards organs/tissues related to Vitreous Syneresis:

40
Bone, Eye, Retina, Skeletal Muscle, Occipital Lobe, Skin

Publications for Vitreous Syneresis

Articles related to Vitreous Syneresis:

(show top 50) (show all 84)
# Title Authors PMID Year
1
Snowflake vitreoretinal degeneration: follow-up of the original family. 61 54
14644728 2003
2
Autosomal recessive Stickler syndrome associated with homozygous mutations in the COL9A2 gene. 61
33356723 2021
3
Variable phenotype of Knobloch syndrome due to biallelic COL18A1 mutations in children. 61
33238767 2020
4
Evaluation of vitreous degeneration as a potential risk factor for retinal detachment after phacoemulsification in dogs. 61
32472635 2020
5
Histopathology of inferior vena cava obstruction in Budd-Chiari syndrome by clamp biopsy. 61
32706600 2020
6
Blue light fromelectronic devicesmay bean important factorforvitreousfloaters. 61
32244150 2020
7
[A Case of Radiation Necrosis in the Right Occipital Lobe Accompanied with Massive Hemorrhage:Histopathological Analysis]. 61
32572007 2020
8
Late-Onset Retinal Findings and Complications in Untreated Retinopathy of Prematurity. 61
32059986 2020
9
Oculo-skeletal dysplasia in five Labrador Retrievers. 61
31595625 2020
10
Vitreous degeneration and associated ocular abnormalities in the dog. 61
31464365 2020
11
Vitreous Antioxidants, Degeneration, and Vitreo-Retinopathy: Exploring the Links. 61
31861871 2019
12
Ocular abnormalities and complications in anterior megalophthalmos: a case series. 61
30617289 2019
13
In vivo imaging of the fibrillar architecture of the posterior vitreous and its relationship to the premacular bursa, Cloquet's canal, prevascular vitreous fissures, and cisterns. 61
30617583 2019
14
Clinical and imaging characteristics of posterior column ataxia with retinitis pigmentosa with a specific FLVCR1 mutation. 61
30444160 2018
15
Genetic variant of Stickler's syndrome. 61
28882395 2018
16
Retinal Detachment in 31 Eyes with Retinitis Pigmentosa. 61
31047295 2018
17
Vitreous changes after intravitreal bevacizumab monotherapy for retinopathy of prematurity: a case series. 61
29568572 2018
18
Macular Hole Development After Vitrectomy for Floaters: A Case Report. 61
29022285 2017
19
An Assessment of Vitreous Degeneration in Eyes with Vitreomacular Traction and Macular Holes. 61
28133544 2017
20
On the Spatiotemporal Material Anisotropy of the Vitreous Body in Tension and Compression. 61
26983839 2016
21
Ophthalmic referrals from emergency wards-a study of cases referred for urgent eye care (The R.E.S.C.U.E Study). 61
27316263 2016
22
[Hereditary vitreous degeneration muddy: report of ten cases]. 61
28247609 2016
23
Age-dependent vitreous separation from the macula in a clinic population. 61
27462138 2016
24
ASSOCIATION OF PREVASCULAR VITREOUS FISSURES AND CISTERNS WITH VITREOUS DEGENERATION AS ASSESSED BY SWEPT SOURCE OPTICAL COHERENCE TOMOGRAPHY. 61
25874366 2015
25
Animal Behavior Case of the Month. Vitreous degeneration. 61
26225605 2015
26
A Retrospective study on the association between vitreous degeneration and cataract in dogs. 61
25319812 2015
27
[Aging and age-related changes of the vitreous body]. 61
26002378 2015
28
Influence of posterior vitreous detachment and type of intraocular lens on lipid peroxidation in the human vitreous. 61
26396488 2015
29
Quantitative imaging of enzymatic vitreolysis-induced fiber remodeling. 61
25468895 2014
30
The premacular bursa's shape revealed in vivo by swept-source optical coherence tomography. 61
24507856 2014
31
Enzymatic degradation identifies components responsible for the structural properties of the vitreous body. 61
24222300 2014
32
Computational model for oxygen transport and consumption in human vitreous. 61
24008409 2013
33
Characterization of the R162W Kir7.1 mutation associated with snowflake vitreoretinopathy. 61
23255580 2013
34
Disease prevalence in geriatric horses in the United Kingdom: veterinary clinical assessment of 200 cases. 61
21668494 2012
35
Histopathological and biochemical alternations of the heart induced by acute cadmium exposure in the freshwater crab Sinopotamon yangtsekiense. 61
21529889 2011
36
Pars plana vitrectomy for visually disturbing vitreous floaters in pseudophacic eyes. 61
21484632 2011
37
Late capsular bag contraction and intraocular lens subluxation in retinitis pigmentosa: a case report. 61
21320335 2011
38
Investigation of fellow eye of unilateral retinal detachment in Shih-Tzu. 61
20840105 2010
39
Pictorial essay: B-scan ultrasonography in ocular abnormalities. 61
19881064 2009
40
The gel state of the vitreous and ascorbate-dependent oxygen consumption: relationship to the etiology of nuclear cataracts. 61
19365028 2009
41
Ocular manifestation of storage diseases. 61
18854696 2008
42
Ultrasonographic evaluation of vitreous degeneration in normal dogs. 61
18418998 2008
43
Clinical characterisation and molecular analysis of Wagner syndrome. 61
17035272 2007
44
Vitreoretinal disorders in anterior megalophthalmos. 61
17180525 2006
45
Vitrectomy with complete posterior hyaloid removal for ischemic central retinal vein occlusion: series of cases. 61
15943889 2005
46
[Experimental study of autologous skin grafting on retained denatured dermis for the treatment of partial thickness burn wound]. 61
15796835 2005
47
[Role of vitrectomy in patients with a decrease in visual acuity secondary to asteroid hyalosis]. 61
15499277 2004
48
[Iodine treatment in vitreous degeneration]. 61
15636254 2004
49
Identification of a stop codon mutation in exon 2 of the collagen 2A1 gene in a large stickler syndrome family. 61
12429249 2002
50
Radial perivascular retinal degeneration: a key to the clinical diagnosis of an ocular variant of Stickler syndrome with minimal or no systemic manifestations. 61
12429250 2002

Variations for Vitreous Syneresis

Expression for Vitreous Syneresis

Search GEO for disease gene expression data for Vitreous Syneresis.

Pathways for Vitreous Syneresis

Pathways related to Vitreous Syneresis according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.49 VCAN COL9A3 COL9A2 COL9A1 COL2A1 COL11A2
2
Show member pathways
13.14 VCAN COL9A3 COL9A2 COL9A1 COL2A1 COL11A2
3
Show member pathways
12.76 VCAN COL9A3 COL9A2 COL9A1 COL2A1 COL11A2
4
Show member pathways
12.65 COL9A3 COL9A2 COL9A1 COL2A1
5
Show member pathways
12.61 COL9A3 COL9A2 COL9A1 COL2A1 COL11A2 COL11A1
6
Show member pathways
12.23 KCNJ13 COL9A3 COL9A2 COL9A1 COL2A1 COL11A2
7
Show member pathways
11.93 COL9A3 COL9A2 COL9A1 COL2A1
8
Show member pathways
11.88 VCAN OPTC COL9A3 COL9A2 COL9A1 COL2A1
9 11.31 VCAN COL9A3 COL9A2 COL9A1
10 11.15 COL9A3 COL9A2 COL9A1
11 11.01 COL9A3 COL9A1
12 10.6 VCAN COL9A3 COL9A2 COL9A1 COL2A1 COL11A2

GO Terms for Vitreous Syneresis

Cellular components related to Vitreous Syneresis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 10.03 VCAN RS1 COL9A3 COL9A2 COL9A1 COL2A1
2 extracellular region GO:0005576 10.02 VCAN RS1 OPTC COL9A3 COL9A2 COL9A1
3 collagen-containing extracellular matrix GO:0062023 9.8 VCAN COL9A3 COL9A2 COL9A1 COL2A1 COL11A2
4 endoplasmic reticulum lumen GO:0005788 9.7 VCAN COL9A3 COL9A2 COL9A1 COL2A1 COL11A2
5 basement membrane GO:0005604 9.65 COL9A3 COL9A1 COL2A1
6 collagen type IX trimer GO:0005594 9.5 COL9A3 COL9A2 COL9A1
7 cytoskeletal calyx GO:0033150 9.46 CYLC2 CYLC1
8 collagen trimer GO:0005581 9.43 COL9A3 COL9A2 COL9A1 COL2A1 COL11A2 COL11A1
9 collagen type XI trimer GO:0005592 9.4 COL11A2 COL11A1
10 extracellular matrix GO:0031012 9.23 VCAN OPTC COL9A3 COL9A2 COL9A1 COL2A1

Biological processes related to Vitreous Syneresis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 visual perception GO:0007601 9.65 RS1 COL2A1 COL11A1
2 sensory perception of sound GO:0007605 9.58 COL2A1 COL11A2 COL11A1
3 cartilage development GO:0051216 9.5 COL2A1 COL11A2 COL11A1
4 chondrocyte differentiation GO:0002062 9.49 COL2A1 COL11A2
5 tissue homeostasis GO:0001894 9.46 COL2A1 COL11A2
6 skeletal system development GO:0001501 9.46 VCAN COL9A2 COL2A1 COL11A2
7 cartilage condensation GO:0001502 9.43 COL2A1 COL11A1
8 skeletal system morphogenesis GO:0048705 9.43 COL2A1 COL11A2 COL11A1
9 proteoglycan metabolic process GO:0006029 9.37 COL2A1 COL11A1
10 collagen fibril organization GO:0030199 9.26 OPTC COL2A1 COL11A2 COL11A1
11 extracellular matrix organization GO:0030198 9.17 VCAN COL9A3 COL9A2 COL9A1 COL2A1 COL11A2

Molecular functions related to Vitreous Syneresis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent GO:0005201 9.5 OPTC COL9A3 COL9A2 COL9A1 COL2A1 COL11A2
2 extracellular matrix structural constituent conferring tensile strength GO:0030020 9.1 COL9A3 COL9A2 COL9A1 COL2A1 COL11A2 COL11A1

Sources for Vitreous Syneresis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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