Aliases & Classifications for Vitreous Syneresis

MalaCards integrated aliases for Vitreous Syneresis:

Name: Vitreous Syneresis 12 15
Vitreous Degeneration 12 55 73

Classifications:



External Ids:

Disease Ontology 12 DOID:11816
ICD10 33 H43.81
ICD9CM 35 379.21
SNOMED-CT 68 247090008 60189009
UMLS 73 C0155366

Summaries for Vitreous Syneresis

MalaCards based summary : Vitreous Syneresis, also known as vitreous degeneration, is related to vitreoretinal degeneration, snowflake type and wagner syndrome. An important gene associated with Vitreous Syneresis is COL2A1 (Collagen Type II Alpha 1 Chain), and among its related pathways/superpathways are Phospholipase-C Pathway and Degradation of the extracellular matrix. The drug Tetrahydrozoline has been mentioned in the context of this disorder. Affiliated tissues include eye, and related phenotypes are immune system and limbs/digits/tail

Related Diseases for Vitreous Syneresis

Graphical network of the top 20 diseases related to Vitreous Syneresis:



Diseases related to Vitreous Syneresis

Symptoms & Phenotypes for Vitreous Syneresis

MGI Mouse Phenotypes related to Vitreous Syneresis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.43 COL11A1 COL2A1 NLRP3 OPTN PRG2 TNFSF13B
2 limbs/digits/tail MP:0005371 8.92 COL11A1 COL2A1 NLRP3 VCAN

Drugs & Therapeutics for Vitreous Syneresis

Drugs for Vitreous Syneresis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Tetrahydrozoline Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effectiveness of Orthokeratology in Decreasing Myopic Progression in a Young Adult Population Enrolled in a Professional Optometric Curriculum Unknown status NCT02623543 Phase 2
2 Clear Vision Study Completed NCT01970267 Not Applicable
3 Effectiveness of Orthokeratology in Myopia Control Recruiting NCT03465748 Not Applicable

Search NIH Clinical Center for Vitreous Syneresis

Genetic Tests for Vitreous Syneresis

Anatomical Context for Vitreous Syneresis

MalaCards organs/tissues related to Vitreous Syneresis:

41
Eye

Publications for Vitreous Syneresis

Articles related to Vitreous Syneresis:

# Title Authors Year
1
Experimental vitreous syneresis. ( 3929752 )
1985

Variations for Vitreous Syneresis

Expression for Vitreous Syneresis

Search GEO for disease gene expression data for Vitreous Syneresis.

Pathways for Vitreous Syneresis

Pathways related to Vitreous Syneresis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.15 COL11A1 COL2A1 PRG2 VCAN
2
Show member pathways
12.09 COL11A1 COL2A1 VCAN
3 10.94 COL2A1 VCAN
4 10.88 COL2A1 TNFSF13B VCAN

GO Terms for Vitreous Syneresis

Cellular components related to Vitreous Syneresis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.33 COL11A1 COL2A1 VCAN
2 extracellular matrix GO:0031012 9.13 COL11A1 COL2A1 VCAN
3 extracellular region GO:0005576 9.1 COL11A1 COL2A1 NLRP3 PRG2 TNFSF13B VCAN

Biological processes related to Vitreous Syneresis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.56 NLRP3 OPTN PRG2 TNFSF13B
2 cartilage development GO:0051216 9.51 COL11A1 COL2A1
3 extracellular matrix organization GO:0030198 9.5 COL11A1 COL2A1 VCAN
4 inner ear morphogenesis GO:0042472 9.49 COL11A1 COL2A1
5 collagen catabolic process GO:0030574 9.48 COL11A1 COL2A1
6 heart morphogenesis GO:0003007 9.46 COL11A1 COL2A1
7 collagen fibril organization GO:0030199 9.43 COL11A1 COL2A1
8 skeletal system morphogenesis GO:0048705 9.4 COL11A1 COL2A1
9 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.37 NLRP3 OPTN
10 cartilage condensation GO:0001502 9.16 COL11A1 COL2A1
11 positive regulation of interleukin-4 production GO:0032753 8.96 NLRP3 PRG2
12 proteoglycan metabolic process GO:0006029 8.62 COL11A1 COL2A1

Molecular functions related to Vitreous Syneresis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding, bridging GO:0030674 8.96 COL11A1 OPTN
2 extracellular matrix structural constituent GO:0005201 8.8 COL11A1 COL2A1 VCAN

Sources for Vitreous Syneresis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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