MCID: VTR002
MIFTS: 30

Vitreous Syneresis

Categories: Eye diseases

Aliases & Classifications for Vitreous Syneresis

MalaCards integrated aliases for Vitreous Syneresis:

Name: Vitreous Syneresis 12 15
Vitreous Degeneration 12 55 73

Classifications:



External Ids:

Disease Ontology 12 DOID:11816
ICD10 33 H43.81
ICD9CM 35 379.21
SNOMED-CT 68 60189009
UMLS 73 C0155366

Summaries for Vitreous Syneresis

MalaCards based summary : Vitreous Syneresis, also known as vitreous degeneration, is related to vitreoretinal degeneration, snowflake type and wagner syndrome. An important gene associated with Vitreous Syneresis is COL2A1 (Collagen Type II Alpha 1 Chain), and among its related pathways/superpathways are Phospholipase-C Pathway and Degradation of the extracellular matrix. The drug Tetrahydrozoline has been mentioned in the context of this disorder. Affiliated tissues include eye and bone, and related phenotypes are immune system and limbs/digits/tail

Related Diseases for Vitreous Syneresis

Graphical network of the top 20 diseases related to Vitreous Syneresis:



Diseases related to Vitreous Syneresis

Symptoms & Phenotypes for Vitreous Syneresis

MGI Mouse Phenotypes related to Vitreous Syneresis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.63 COL11A1 COL2A1 NLRP3 OPTN PRG2 TNFSF13B
2 limbs/digits/tail MP:0005371 9.26 COL11A1 COL2A1 NLRP3 VCAN
3 skeleton MP:0005390 9.02 COL11A1 COL2A1 KCNJ13 NLRP3 VCAN

Drugs & Therapeutics for Vitreous Syneresis

Drugs for Vitreous Syneresis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Tetrahydrozoline Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effectiveness of Orthokeratology in Decreasing Myopic Progression in a Young Adult Population Enrolled in a Professional Optometric Curriculum Unknown status NCT02623543 Phase 2
2 Clear Vision Study Completed NCT01970267 Not Applicable
3 Effectiveness of Orthokeratology in Myopia Control Recruiting NCT03465748 Not Applicable

Search NIH Clinical Center for Vitreous Syneresis

Genetic Tests for Vitreous Syneresis

Anatomical Context for Vitreous Syneresis

MalaCards organs/tissues related to Vitreous Syneresis:

41
Eye, Bone

Publications for Vitreous Syneresis

Articles related to Vitreous Syneresis:

# Title Authors Year
1
An Assessment of Vitreous Degeneration in Eyes with Vitreomacular Traction and Macular Holes. ( 28133544 )
2017
2
A Retrospective study on the association between vitreous degeneration and cataract in dogs. ( 25319812 )
2015
3
ASSOCIATION OF PREVASCULAR VITREOUS FISSURES AND CISTERNS WITH VITREOUS DEGENERATION AS ASSESSED BY SWEPT SOURCE OPTICAL COHERENCE TOMOGRAPHY. ( 25874366 )
2015
4
Animal Behavior Case of the Month. Vitreous degeneration. ( 26225605 )
2015
5
Ultrasonographic evaluation of vitreous degeneration in normal dogs. ( 18418998 )
2008
6
Vitreous degeneration in myopia and retinitis pigmentosa. ( 3307966 )
1987
7
Vitreous fluorophotometry in vitreous degeneration. ( 3632404 )
1987
8
Experimental vitreous syneresis. ( 3929752 )
1985

Variations for Vitreous Syneresis

Expression for Vitreous Syneresis

Search GEO for disease gene expression data for Vitreous Syneresis.

Pathways for Vitreous Syneresis

GO Terms for Vitreous Syneresis

Cellular components related to Vitreous Syneresis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix GO:0031012 9.43 COL11A1 COL2A1 VCAN
2 extracellular region GO:0005576 9.43 COL11A1 COL2A1 NLRP3 PRG2 TNFSF13B VCAN
3 endoplasmic reticulum lumen GO:0005788 9.33 COL11A1 COL2A1 VCAN
4 collagen trimer GO:0005581 9.32 COL11A1 COL2A1
5 collagen-containing extracellular matrix GO:0062023 8.92 COL11A1 COL2A1 PRG2 VCAN

Biological processes related to Vitreous Syneresis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cartilage development GO:0051216 9.43 COL11A1 COL2A1
2 inner ear morphogenesis GO:0042472 9.4 COL11A1 COL2A1
3 heart morphogenesis GO:0003007 9.37 COL11A1 COL2A1
4 extracellular matrix organization GO:0030198 9.33 COL11A1 COL2A1 VCAN
5 collagen fibril organization GO:0030199 9.32 COL11A1 COL2A1
6 skeletal system morphogenesis GO:0048705 9.26 COL11A1 COL2A1
7 cartilage condensation GO:0001502 8.96 COL11A1 COL2A1
8 proteoglycan metabolic process GO:0006029 8.62 COL11A1 COL2A1

Molecular functions related to Vitreous Syneresis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding, bridging GO:0030674 9.16 COL11A1 OPTN
2 extracellular matrix structural constituent conferring tensile strength GO:0030020 8.96 COL11A1 COL2A1
3 extracellular matrix structural constituent conferring compression resistance GO:0030021 8.62 PRG2 VCAN

Sources for Vitreous Syneresis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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