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MCID: VTR002
MIFTS: 31

Vitreous Syneresis

Categories: Neuronal diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Vitreous Syneresis

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MalaCards integrated aliases for Vitreous Syneresis:

Name: Vitreous Syneresis 12 15
Vitreous Degeneration 12 54 71

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:11816
ICD9CM 34 379.21
SNOMED-CT 67 60189009
ICD10 32 H43.81
UMLS 71 C0155366
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Summaries for Vitreous Syneresis

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MalaCards based summary : Vitreous Syneresis, also known as vitreous degeneration, is related to vitreous detachment and macular holes. An important gene associated with Vitreous Syneresis is COL2A1 (Collagen Type II Alpha 1 Chain), and among its related pathways/superpathways are Integrin Pathway and Phospholipase-C Pathway. Affiliated tissues include eye, retina and heart, and related phenotype is hearing/vestibular/ear.

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Related Diseases for Vitreous Syneresis

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Diseases related to Vitreous Syneresis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 74)
# Related Disease Score Top Affiliating Genes
1 vitreous detachment 30.4 OPTC CYLC1 COL2A1
2 macular holes 29.4 RS1 OPTC
3 retinal detachment 28.9 RS1 KCNJ13 COL9A2 COL2A1 COL11A1
4 cataract 28.7 VCAN KCNJ13 COL2A1 COL11A1
5 myopia 28.4 VCAN OPTC COL9A2 COL2A1 COL11A2 COL11A1
6 vitreoretinal degeneration, snowflake type 11.2
7 multiple epiphyseal dysplasia, autosomal dominant 10.3 COL9A3 COL9A2
8 epiphyseal dysplasia, multiple, 6 10.3 COL9A3 COL9A2
9 back pain 10.3 COL9A3 COL9A2
10 scheuermann disease 10.3 COL9A3 COL2A1
11 epiphyseal dysplasia, multiple, 5 10.3 COL9A3 COL9A2
12 macroglossia 10.3 COL2A1 COL11A1
13 epiphyseal dysplasia, multiple, 1 10.2 COL9A3 COL9A2
14 vitreous disease 10.2 OPTC COL2A1
15 atelosteogenesis 10.2 COL9A3 COL9A2
16 epiphyseal dysplasia, multiple, 4 10.2 COL9A3 COL9A2
17 achondrogenesis, type ii 10.2 COL2A1 COL11A2
18 osteochondrosis 10.1 COL9A3 COL9A2 COL2A1
19 achondrogenesis 10.1 COL9A3 COL9A2 COL2A1
20 diastrophic dysplasia 10.1 COL9A3 COL9A2 COL2A1
21 fibrochondrogenesis 1 10.1 COL11A2 COL11A1
22 osteochondritis dissecans 10.1 COL9A3 COL9A2 COL2A1
23 bone deterioration disease 10.1 COL9A3 COL9A2 COL2A1
24 pseudoachondroplasia 10.1 COL9A3 COL9A2 COL2A1
25 bone structure disease 10.1 COL9A3 COL9A2 COL2A1
26 caffey disease 10.1 COL2A1 COL11A2
27 wagner syndrome 10.1 VCAN COL2A1
28 autosomal recessive stickler syndrome 10.1 COL9A3 COL9A2 COL11A1
29 epiphyseal dysplasia, multiple, 3 10.0 SMAP2 COL9A3 COL9A2
30 epiphyseal dysplasia, multiple, 2 10.0 SMAP2 COL9A3 COL9A2
31 spondyloepiphyseal dysplasia congenita 10.0 COL9A3 COL2A1 COL11A2
32 kohler's disease 10.0 COL2A1 COL11A2 COL11A1
33 uveitis 10.0
34 phacoanaphylactic uveitis 10.0
35 otospondylomegaepiphyseal dysplasia, autosomal dominant 10.0 COL2A1 COL11A2 COL11A1
36 schneckenbecken dysplasia 10.0 COL2A1 COL11A2 COL11A1
37 cleft soft palate 10.0 COL2A1 COL11A2 COL11A1
38 secondary corneal edema 10.0 SFTA3 CYLC1
39 campomelic dysplasia 9.9 COL2A1 COL11A2
40 cycloplegia 9.9 SFTA3 CYLC1
41 eye accommodation disease 9.9 SFTA3 CYLC1
42 spherocytosis, type 2 9.9 SFTA3 CYLC1
43 esotropia 9.9 CYLC1 COL11A1
44 retinitis pigmentosa 9.8
45 joint laxity, short stature, and myopia 9.8
46 neuroretinitis 9.8
47 lens subluxation 9.8
48 retinitis 9.8
49 eye disease 9.8
50 spherocytosis, type 1 9.8 SFTA3 CYLC1

Graphical network of the top 20 diseases related to Vitreous Syneresis:



Diseases related to Vitreous Syneresis
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Symptoms & Phenotypes for Vitreous Syneresis

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MGI Mouse Phenotypes related to Vitreous Syneresis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hearing/vestibular/ear MP:0005377 9.02 COL11A1 COL11A2 COL2A1 COL9A2 COL9A3
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Drugs & Therapeutics for Vitreous Syneresis

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Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluation of Blood-retinal Barrier Functional Alterations by Optical Coherence Tomography Completed NCT01220804
2 Randomized Trial of Laser Ablation for Highly Symptomatic Floaters Completed NCT01970267

Search NIH Clinical Center for Vitreous Syneresis

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Genetic Tests for Vitreous Syneresis

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Anatomical Context for Vitreous Syneresis

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MalaCards organs/tissues related to Vitreous Syneresis:

40
Eye, Retina, Heart, Skeletal Muscle, Skin, Occipital Lobe
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Publications for Vitreous Syneresis

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Articles related to Vitreous Syneresis:

(show top 50) (show all 81)
# Title Authors PMID Year
1
Snowflake vitreoretinal degeneration: follow-up of the original family. 54 61
14644728 2003
2
Late-Onset Retinal Findings and Complications in Untreated Retinopathy of Prematurity. 61
32059986 2020
3
Blue light fromelectronic devicesmay bean important factorforvitreousfloaters. 61
32244150 2020
4
[A Case of Radiation Necrosis in the Right Occipital Lobe Accompanied with Massive Hemorrhage:Histopathological Analysis]. 61
32572007 2020
5
Evaluation of vitreous degeneration as a potential risk factor for retinal detachment after phacoemulsification in dogs. 61
32472635 2020
6
Oculo-skeletal dysplasia in five Labrador Retrievers. 61
31595625 2020
7
Vitreous degeneration and associated ocular abnormalities in the dog. 61
31464365 2020
8
Vitreous Antioxidants, Degeneration, and Vitreo-Retinopathy: Exploring the Links. 61
31861871 2019
9
Ocular abnormalities and complications in anterior megalophthalmos: a case series. 61
30617289 2019
10
In vivo imaging of the fibrillar architecture of the posterior vitreous and its relationship to the premacular bursa, Cloquet's canal, prevascular vitreous fissures, and cisterns. 61
30617583 2019
11
Clinical and imaging characteristics of posterior column ataxia with retinitis pigmentosa with a specific FLVCR1 mutation. 61
30444160 2018
12
Genetic variant of Stickler's syndrome. 61
28882395 2018
13
Retinal Detachment in 31 Eyes with Retinitis Pigmentosa. 61
31047295 2018
14
Vitreous changes after intravitreal bevacizumab monotherapy for retinopathy of prematurity: a case series. 61
29568572 2018
15
Macular Hole Development After Vitrectomy for Floaters: A Case Report. 61
29022285 2017
16
An Assessment of Vitreous Degeneration in Eyes with Vitreomacular Traction and Macular Holes. 61
28133544 2017
17
On the Spatiotemporal Material Anisotropy of the Vitreous Body in Tension and Compression. 61
26983839 2016
18
Ophthalmic referrals from emergency wards-a study of cases referred for urgent eye care (The R.E.S.C.U.E Study). 61
27316263 2016
19
[Hereditary vitreous degeneration muddy: report of ten cases]. 61
28247609 2016
20
Age-dependent vitreous separation from the macula in a clinic population. 61
27462138 2016
21
ASSOCIATION OF PREVASCULAR VITREOUS FISSURES AND CISTERNS WITH VITREOUS DEGENERATION AS ASSESSED BY SWEPT SOURCE OPTICAL COHERENCE TOMOGRAPHY. 61
25874366 2015
22
Animal Behavior Case of the Month. Vitreous degeneration. 61
26225605 2015
23
[Aging and age-related changes of the vitreous body]. 61
26002378 2015
24
A Retrospective study on the association between vitreous degeneration and cataract in dogs. 61
25319812 2015
25
Influence of posterior vitreous detachment and type of intraocular lens on lipid peroxidation in the human vitreous. 61
26396488 2015
26
Quantitative imaging of enzymatic vitreolysis-induced fiber remodeling. 61
25468895 2014
27
The premacular bursa's shape revealed in vivo by swept-source optical coherence tomography. 61
24507856 2014
28
Enzymatic degradation identifies components responsible for the structural properties of the vitreous body. 61
24222300 2014
29
Computational model for oxygen transport and consumption in human vitreous. 61
24008409 2013
30
Characterization of the R162W Kir7.1 mutation associated with snowflake vitreoretinopathy. 61
23255580 2013
31
Disease prevalence in geriatric horses in the United Kingdom: veterinary clinical assessment of 200 cases. 61
21668494 2012
32
Histopathological and biochemical alternations of the heart induced by acute cadmium exposure in the freshwater crab Sinopotamon yangtsekiense. 61
21529889 2011
33
Pars plana vitrectomy for visually disturbing vitreous floaters in pseudophacic eyes. 61
21484632 2011
34
Late capsular bag contraction and intraocular lens subluxation in retinitis pigmentosa: a case report. 61
21320335 2011
35
Investigation of fellow eye of unilateral retinal detachment in Shih-Tzu. 61
20840105 2010
36
Pictorial essay: B-scan ultrasonography in ocular abnormalities. 61
19881064 2009
37
The gel state of the vitreous and ascorbate-dependent oxygen consumption: relationship to the etiology of nuclear cataracts. 61
19365028 2009
38
Ocular manifestation of storage diseases. 61
18854696 2008
39
Ultrasonographic evaluation of vitreous degeneration in normal dogs. 61
18418998 2008
40
Clinical characterisation and molecular analysis of Wagner syndrome. 61
17035272 2007
41
Vitreoretinal disorders in anterior megalophthalmos. 61
17180525 2006
42
Vitrectomy with complete posterior hyaloid removal for ischemic central retinal vein occlusion: series of cases. 61
15943889 2005
43
[Experimental study of autologous skin grafting on retained denatured dermis for the treatment of partial thickness burn wound]. 61
15796835 2005
44
[Role of vitrectomy in patients with a decrease in visual acuity secondary to asteroid hyalosis]. 61
15499277 2004
45
[Iodine treatment in vitreous degeneration]. 61
15636254 2004
46
Identification of a stop codon mutation in exon 2 of the collagen 2A1 gene in a large stickler syndrome family. 61
12429249 2002
47
Radial perivascular retinal degeneration: a key to the clinical diagnosis of an ocular variant of Stickler syndrome with minimal or no systemic manifestations. 61
12429250 2002
48
A case of erosive vitreoretinopathy. 61
12162518 2002
49
The effects of exposure to a 1.5-tesla magnetic field on intravitreous metallic foreign bodies in rabbits. 61
12073063 2002
50
[A macular hole in the eye of a young patient with retinitis pigmentosa]. 61
11979984 2002
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Variations for Vitreous Syneresis

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Expression for Vitreous Syneresis

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Search GEO for disease gene expression data for Vitreous Syneresis.
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Pathways for Vitreous Syneresis

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Pathways related to Vitreous Syneresis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Integrin Pathway 63
Show member pathways
 13.02 VCAN COL9A3 COL9A2 COL2A1 COL11A2 COL11A1
2
Phospholipase-C Pathway 63
Show member pathways
 12.63 VCAN COL9A3 COL9A2 COL2A1 COL11A2 COL11A1
3
Focal Adhesion 36 1
Show member pathways
 12.53 COL9A3 COL9A2 COL2A1 COL11A2 COL11A1
4
Collagen chain trimerization 65
Show member pathways
 12.16 KCNJ13 COL9A3 COL9A2 COL2A1 COL11A2 COL11A1
5
Degradation of the extracellular matrix 65
Show member pathways
 11.82 VCAN OPTC COL9A3 COL9A2 COL2A1 COL11A2
6
ECM-receptor interaction 36
Show member pathways
 11.8 COL9A3 COL9A2 COL2A1
7
ECM proteoglycans 65
11.25 VCAN COL9A3 COL9A2
8
NCAM1 interactions 65
11.02 COL9A3 COL9A2
9
G-protein signaling_Rap2B regulation pathway 22
10.54 VCAN COL9A3 COL9A2 COL2A1 COL11A2 COL11A1
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GO Terms for Vitreous Syneresis

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Cellular components related to Vitreous Syneresis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.97 VCAN SFTA3 RS1 COL9A3 COL9A2 COL2A1
2 extracellular region GO:0005576 9.97 VCAN SFTA3 RS1 OPTC COL9A3 COL9A2
3 collagen-containing extracellular matrix GO:0062023 9.73 VCAN COL9A3 COL9A2 COL2A1 COL11A2 COL11A1
4 endoplasmic reticulum lumen GO:0005788 9.63 VCAN COL9A3 COL9A2 COL2A1 COL11A2 COL11A1
5 collagen type IX trimer GO:0005594 9.46 COL9A3 COL9A2
6 cytoskeletal calyx GO:0033150 9.43 CYLC2 CYLC1
7 collagen type XI trimer GO:0005592 9.4 COL11A2 COL11A1
8 collagen trimer GO:0005581 9.35 COL9A3 COL9A2 COL2A1 COL11A2 COL11A1
9 extracellular matrix GO:0031012 9.17 VCAN OPTC COL9A3 COL9A2 COL2A1 COL11A2

Biological processes related to Vitreous Syneresis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 visual perception GO:0007601 9.65 RS1 COL2A1 COL11A1
2 sensory perception of sound GO:0007605 9.58 COL2A1 COL11A2 COL11A1
3 cartilage development GO:0051216 9.54 COL2A1 COL11A2 COL11A1
4 chondrocyte differentiation GO:0002062 9.49 COL2A1 COL11A2
5 tissue homeostasis GO:0001894 9.46 COL2A1 COL11A2
6 skeletal system development GO:0001501 9.46 VCAN COL9A2 COL2A1 COL11A2
7 cartilage condensation GO:0001502 9.43 COL2A1 COL11A1
8 skeletal system morphogenesis GO:0048705 9.43 COL2A1 COL11A2 COL11A1
9 proteoglycan metabolic process GO:0006029 9.32 COL2A1 COL11A1
10 collagen fibril organization GO:0030199 9.26 OPTC COL2A1 COL11A2 COL11A1
11 extracellular matrix organization GO:0030198 9.1 VCAN COL9A3 COL9A2 COL2A1 COL11A2 COL11A1

Molecular functions related to Vitreous Syneresis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent GO:0005201 9.43 OPTC COL9A3 COL9A2 COL2A1 COL11A2 COL11A1
2 extracellular matrix structural constituent conferring tensile strength GO:0030020 9.02 COL9A3 COL9A2 COL2A1 COL11A2 COL11A1
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Sources for Vitreous Syneresis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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