MCID: VGT001
MIFTS: 59

Vogt-Koyanagi-Harada Disease

Categories: Eye diseases, Immune diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Vogt-Koyanagi-Harada Disease

MalaCards integrated aliases for Vogt-Koyanagi-Harada Disease:

Name: Vogt-Koyanagi-Harada Disease 12 54 60 56 15
Uveomeningoencephalitic Syndrome 12 45 74
Vogt-Koyanagi-Harada Syndrome 54 38
Uveomenigitic Syndrome 54 60
Vogt-Koyanagi Syndrome 12
Harada's Disease 12
Vkh Syndrome 54
Vkh Disease 54

Characteristics:

Orphanet epidemiological data:

60
vogt-koyanagi-harada disease
Inheritance: Multigenic/multifactorial; Age of onset: All ages; Age of death: normal life expectancy;

Classifications:



External Ids:

Disease Ontology 12 DOID:12297
KEGG 38 H01504
ICD9CM 36 363.22 364.24
MeSH 45 D014607
NCIt 51 C85218
SNOMED-CT 69 44923005 47230004
ICD10 34 H20.82 H30.81
ICD10 via Orphanet 35 H20.8 H30.8
UMLS via Orphanet 75 C0042170
Orphanet 60 ORPHA3437
UMLS 74 C0042170

Summaries for Vogt-Koyanagi-Harada Disease

NIH Rare Diseases : 54 Vogt-Koyanagi-Harada disease (VKH disease) is a disease that affects several parts of the body, including the eyes, ears, nervous system, and skin. The signs and symptoms of VKH disease are caused by chronic inflammation of melanocytes. Melanocytes are specialized cells that produce a pigment called melanin. Melanin is the substance that gives skin, hair, and eyes their color. Melanin is also found in other parts of the body, such as the retina of the eyes, where it plays a role in normal vision, and in the inner ear, where it is thought to be involved in hearing. People with VKH disease usually develop vision and hearing problems first, followed by signs of skin problems. The most common symptoms include headaches, inflammation of all layers of the colored part of the eye (panuveitis), white patches of skin (vitiligo), hair loss (alopecia), dizziness and nausea (inner ear related problems), and vision and hearing loss. Neurological symptoms may also occur. The exact cause of VKH disease is not well understood, but research suggests it is an autoimmune disease. It is more common in people with darker skin color including Asian, Middle Eastern, Hispanic, and Native American populations. The disease is treated with corticosteroids and other medications.

MalaCards based summary : Vogt-Koyanagi-Harada Disease, also known as uveomeningoencephalitic syndrome, is related to uveitis and pars planitis. An important gene associated with Vogt-Koyanagi-Harada Disease is PTPN22 (Protein Tyrosine Phosphatase Non-Receptor Type 22), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. The drugs Bevacizumab and Angiogenesis Modulating Agents have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and retina, and related phenotypes are sensorineural hearing impairment and cognitive impairment

Disease Ontology : 12 An autoimmune hypersensitivity disease that is caused by T helper cell mediated autoimmune attack of melanocytes resulting in inflammation of the inside of the eye, whitening of hair, skin pigment loss, and meningitis.

Wikipedia : 77 Vogt–Koyanagi–Harada disease (VKH), is a multisystem disease of presumed autoimmune cause, that... more...

Related Diseases for Vogt-Koyanagi-Harada Disease

Diseases related to Vogt-Koyanagi-Harada Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 211)
# Related Disease Score Top Affiliating Genes
1 uveitis 31.2 HLA-B IL10 IL17A IL2RA
2 pars planitis 31.1 HLA-A HLA-B HLA-DRB1
3 halo nevi 30.9 HLA-DRB1 PMEL TYR
4 anterior uveitis 30.9 HLA-A HLA-B IL2RA
5 graves' disease 30.7 HLA-DQA1 HLA-DRB1 IL2RA PTPN22
6 vitiligo-associated multiple autoimmune disease susceptibility 1 30.6 NLRP1 PMEL PTPN22 TYR TYRP1
7 herpes zoster 30.3 HLA-A HLA-B IL10
8 panuveitis 29.8 HLA-A HLA-B HLA-DQB1 HLA-DRB1 IL10 IL17A
9 arthritis 29.6 HLA-DQB1 HLA-DRB1 IL10 IL17A NLRP1 PTPN22
10 diabetes mellitus 29.5 FAS HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
11 autoimmune disease 28.9 FAS HLA-DQB1 HLA-DRB1 IL10 IL17A IL2RA
12 rheumatoid arthritis 28.8 HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10 IL17A
13 alezzandrini syndrome 11.7
14 hepatitis 10.8
15 retinal detachment 10.8
16 hepatitis c 10.8
17 melanoma 10.8
18 sympathetic ophthalmia 10.7
19 headache 10.7
20 leukemia 10.6
21 scleritis 10.6
22 central serous chorioretinopathy 10.6
23 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.6
24 alopecia 10.6
25 lymphoma 10.6
26 choroiditis 10.6
27 posterior scleritis 10.6
28 neuropathy 10.6
29 acute posterior multifocal placoid pigment epitheliopathy 10.6
30 aseptic meningitis 10.6
31 cataract 10.5
32 lymphocytic leukemia 10.5
33 meningoencephalitis 10.5
34 optic neuritis 10.5
35 posterior uveitis 10.5
36 acute closed-angle glaucoma 10.5
37 neuritis 10.5
38 optic nerve disease 10.5
39 macular holes 10.5
40 myeloid leukemia 10.5
41 psoriasis 10.5
42 meningitis 10.5
43 degos 'en cocarde' erythrokeratoderma 10.5
44 homocysteinemia 10.5
45 limbic encephalitis with lgi1 antibodies 10.5 HLA-DQB1 HLA-DRB1
46 narcolepsy 2 10.4 HLA-DQB1 HLA-DRB1
47 autoimmune polyglandular syndrome type 3 10.4 HLA-DQB1 HLA-DRB1
48 hypersomnia 10.4 HLA-DQB1 HLA-DRB1
49 metal allergy 10.4 HLA-DQB1 HLA-DRB1
50 lichen planopilaris 10.4 HLA-DQB1 HLA-DRB1

Graphical network of the top 20 diseases related to Vogt-Koyanagi-Harada Disease:



Diseases related to Vogt-Koyanagi-Harada Disease

Symptoms & Phenotypes for Vogt-Koyanagi-Harada Disease

Human phenotypes related to Vogt-Koyanagi-Harada Disease:

60 33 (show all 16)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 sensorineural hearing impairment 60 33 hallmark (90%) Very frequent (99-80%) HP:0000407
2 cognitive impairment 60 33 hallmark (90%) Very frequent (99-80%) HP:0100543
3 vitiligo 60 33 hallmark (90%) Very frequent (99-80%) HP:0001045
4 hypopigmented skin patches 60 33 hallmark (90%) Very frequent (99-80%) HP:0001053
5 premature graying of hair 60 33 hallmark (90%) Very frequent (99-80%) HP:0002216
6 sparse scalp hair 60 33 hallmark (90%) Very frequent (99-80%) HP:0002209
7 poliosis 60 33 hallmark (90%) Very frequent (99-80%) HP:0002290
8 abnormal eyelash morphology 33 hallmark (90%) HP:0000499
9 abnormal eyebrow morphology 33 hallmark (90%) HP:0000534
10 cataract 60 33 frequent (33%) Frequent (79-30%) HP:0000518
11 visual impairment 60 33 frequent (33%) Frequent (79-30%) HP:0000505
12 short stature 60 33 frequent (33%) Frequent (79-30%) HP:0004322
13 glaucoma 60 33 frequent (33%) Frequent (79-30%) HP:0000501
14 retinal detachment 60 33 frequent (33%) Frequent (79-30%) HP:0000541
15 abnormality of the eyelashes 60 Very frequent (99-80%)
16 abnormality of the eyebrow 60 Very frequent (99-80%)

GenomeRNAi Phenotypes related to Vogt-Koyanagi-Harada Disease according to GeneCards Suite gene sharing:

27 (show all 30)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 10.27 HLA-A HLA-B
2 Increased shRNA abundance (Z-score > 2) GR00366-A-110 10.27 HLA-A HLA-B HLA-DQA1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-115 10.27 IL2RA
4 Increased shRNA abundance (Z-score > 2) GR00366-A-118 10.27 HLA-A HLA-B
5 Increased shRNA abundance (Z-score > 2) GR00366-A-121 10.27 HLA-DQA1 IL2RA
6 Increased shRNA abundance (Z-score > 2) GR00366-A-130 10.27 IL2RA
7 Increased shRNA abundance (Z-score > 2) GR00366-A-138 10.27 IL2RA
8 Increased shRNA abundance (Z-score > 2) GR00366-A-149 10.27 HLA-DQA1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-156 10.27 HLA-A HLA-B
10 Increased shRNA abundance (Z-score > 2) GR00366-A-169 10.27 IL2RA
11 Increased shRNA abundance (Z-score > 2) GR00366-A-174 10.27 IL2RA
12 Increased shRNA abundance (Z-score > 2) GR00366-A-178 10.27 HLA-A HLA-B
13 Increased shRNA abundance (Z-score > 2) GR00366-A-185 10.27 IL2RA
14 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.27 HLA-A HLA-B HLA-DQA1 IL2RA
15 Increased shRNA abundance (Z-score > 2) GR00366-A-2 10.27 IL2RA
16 Increased shRNA abundance (Z-score > 2) GR00366-A-202 10.27 IL2RA
17 Increased shRNA abundance (Z-score > 2) GR00366-A-25 10.27 IL2RA
18 Increased shRNA abundance (Z-score > 2) GR00366-A-31 10.27 HLA-A HLA-B
19 Increased shRNA abundance (Z-score > 2) GR00366-A-45 10.27 HLA-DQA1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-46 10.27 IL2RA
21 Increased shRNA abundance (Z-score > 2) GR00366-A-50 10.27 IL2RA
22 Increased shRNA abundance (Z-score > 2) GR00366-A-52 10.27 IL2RA
23 Increased shRNA abundance (Z-score > 2) GR00366-A-67 10.27 IL2RA
24 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.27 HLA-A HLA-B
25 Increased shRNA abundance (Z-score > 2) GR00366-A-73 10.27 HLA-DQA1
26 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.27 HLA-A HLA-B
27 Increased shRNA abundance (Z-score > 2) GR00366-A-9 10.27 IL2RA
28 Increased shRNA abundance (Z-score > 2) GR00366-A-99 10.27 HLA-DQA1
29 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.77 FAS HLA-DQB1 IL10 IL17A IL2RA NLRP1
30 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.77 FAS HLA-DQB1 IL10 IL17A IL2RA NLRP1

MGI Mouse Phenotypes related to Vogt-Koyanagi-Harada Disease:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.03 FAS HLA-DQA1 HLA-DQB1 IL10 IL17A IL2RA
2 endocrine/exocrine gland MP:0005379 9.97 FAS HLA-DQA1 HLA-DQB1 IL10 IL17A IL2RA
3 homeostasis/metabolism MP:0005376 9.9 FAS HLA-DQB1 IL10 IL17A IL2RA NLRP1
4 immune system MP:0005387 9.7 FAS HLA-DQA1 HLA-DQB1 IL10 IL17A IL2RA
5 respiratory system MP:0005388 9.17 FAS HLA-DQB1 IL10 IL17A IL2RA PTPN22

Drugs & Therapeutics for Vogt-Koyanagi-Harada Disease

Drugs for Vogt-Koyanagi-Harada Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 43)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 3,Not Applicable 216974-75-3
2 Angiogenesis Modulating Agents Phase 3,Not Applicable
3 Angiogenesis Inhibitors Phase 3,Not Applicable
4 Antineoplastic Agents, Immunological Phase 3,Not Applicable
5
Iodine Approved, Investigational Not Applicable 7553-56-2 807
6
Azathioprine Approved Not Applicable 446-86-6 2265
7
Miconazole Approved, Investigational, Vet_approved Not Applicable 22916-47-8 4189
8
Mycophenolic acid Approved Not Applicable 24280-93-1 446541
9
Povidone Approved Not Applicable 9003-39-8
10
Povidone-iodine Approved Not Applicable 25655-41-8
11
Infliximab Approved 170277-31-3
12
rituximab Approved 174722-31-7 10201696
13
Adalimumab Approved 331731-18-1 16219006
14
Etanercept Approved, Investigational 185243-69-0
15
Methylprednisolone hemisuccinate Approved ,Not Applicable 2921-57-5
16
Methotrexate Approved 1959-05-2, 59-05-2 126941
17
Prednisolone phosphate Approved, Vet_approved ,Not Applicable 302-25-0
18
Prednisolone Approved, Vet_approved ,Not Applicable 50-24-8 5755
19
Methylprednisolone Approved, Vet_approved ,Not Applicable 83-43-2 6741
20
Prednisone Approved, Vet_approved Not Applicable 53-03-2 5865
21
Prednisolone hemisuccinate Experimental ,Not Applicable 2920-86-7
22 Anti-Bacterial Agents Not Applicable
23 Anti-Infective Agents Not Applicable
24 Immunologic Factors Not Applicable
25 Antibiotics, Antitubercular Not Applicable
26 Immunosuppressive Agents Not Applicable
27 Antirheumatic Agents Not Applicable
28 Calcineurin Inhibitors Not Applicable
29 Cyclosporins Not Applicable
30 Antifungal Agents Not Applicable
31 cadexomer iodine Not Applicable
32 Dermatologic Agents Not Applicable
33 Methylprednisolone Acetate ,Not Applicable
34 Prednisolone acetate ,Not Applicable
35 Antitubercular Agents
36 Antimetabolites
37 Antimetabolites, Antineoplastic
38 Antineoplastic Agents, Hormonal Not Applicable
39 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable
40 glucocorticoids Not Applicable
41 Anti-Inflammatory Agents Not Applicable
42 Hormones Not Applicable
43 Hormone Antagonists Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Intravitreal Bevacizumab for Inflammatory Neovascular Membranes Completed NCT00407121 Phase 3 Bevacizumab
2 Intravitreal Bevacizumab for the Treatment of CNV in VKH Disease - A Prospective Study Unknown status NCT02015351 Not Applicable bevacizumab
3 Causes of Visual Loss in Retinal Disease Unknown status NCT01613963 Immunosuppressive Agents
4 Multimodal Analysis and Electroretinogram in VKH From Acute Onset - Part I Completed NCT03811366 Not Applicable Meticorten
5 Early Immunosuppressive Therapy on the Course of Vogt-Koyanagi-Harada Disease Recruiting NCT03399175 Not Applicable Early high-dose corticosteroid and immunosuppressive therapy

Search NIH Clinical Center for Vogt-Koyanagi-Harada Disease

Cochrane evidence based reviews: uveomeningoencephalitic syndrome

Genetic Tests for Vogt-Koyanagi-Harada Disease

Anatomical Context for Vogt-Koyanagi-Harada Disease

MalaCards organs/tissues related to Vogt-Koyanagi-Harada Disease:

42
Eye, Skin, Retina, T Cells, Myeloid, Ovary, Spinal Cord

Publications for Vogt-Koyanagi-Harada Disease

Articles related to Vogt-Koyanagi-Harada Disease:

(show top 50) (show all 461)
# Title Authors Year
1
Vogt-Koyanagi-Harada Disease and Birdshot Retinochoroidopathy, Similarities and Differences: A Glimpse into the Clinicopathology of Stromal Choroiditis, a Perspective and a Review. ( 30891715 )
2019
2
Vogt-Koyanagi-Harada Disease-Like Uveitis during Nivolumab (Anti-PD-1 Antibody) Treatment for Metastatic Cutaneous Malignant Melanoma. ( 31097947 )
2019
3
Acquired myopia in Vogt-Koyanagi-Harada disease. ( 29397539 )
2019
4
Neurosarcoidosis Occurring 6 Years after Onset of Vogt-Koyanagi-Harada Disease. ( 31097942 )
2019
5
Comparison of Clinical Features and Visual Outcome between Sympathetic Ophthalmia and Vogt-Koyanagi-Harada Disease in Chinese Patients. ( 30959067 )
2019
6
Comparison of clinical characteristics in patients with Vogt-Koyanagi-Harada disease with and without anti-retinal antibodies. ( 31065846 )
2019
7
Choroidal Vasculature from Ultra-Widefield Images without Contrast Dye and Its Application to Vogt-Koyanagi-Harada Disease. ( 31014767 )
2019
8
Initial misdiagnosis of Vogt-Koyanagi-Harada disease. ( 30930664 )
2019
9
"Revised diagnostic criteria" for Vogt-Koyanagi-Harada disease fail to improve disease management. ( 30899839 )
2019
10
Vogt-Koyanagi-Harada disease. ( 30890584 )
2019
11
Azathioprine During the First Trimester of Pregnancy in a Patient with Vogt-Koyanagi-Harada Disease: A Multimodal Imaging Follow-Up Study. ( 30842390 )
2019
12
Th lymphocyte subsets in patients with Vogt-Koyanagi-Harada disease. ( 30809474 )
2019
13
A case of recalcitrant pediatric Vogt-Koyanagi-Harada disease successfully controlled with adalimumab. ( 30616991 )
2019
14
Vogt-Koyanagi-Harada disease: study of 14 cases. ( 29731134 )
2019
15
Clinical features and visual outcomes of 111 patients with new-onset acute Vogt-Koyanagi-Harada disease treated with pulse intravenous corticosteroids. ( 29666121 )
2019
16
Tattoo granulomas with uveitis rather than Vogt-Koyanagi-Harada disease after tattooing? ( 31109485 )
2019
17
Retinal vessel oxygen saturation is affected in uveitis associated with Vogt-Koyanagi-Harada disease. ( 30798260 )
2019
18
The Choroidal Vascularity Index Decreases and Choroidal Thickness Increases in Vogt-Koyanagi-Harada Disease Patients During a Recurrent Anterior Uveitis Attack. ( 28914578 )
2018
19
TUBERCULOUS CHOROIDITIS IN PATIENT WITH VOGT-KOYANAGI-HARADA DISEASE. ( 30074567 )
2018
20
Probable Vogt-Koyanagi-Harada disease with granulomatous tattoo-related dermatitis. ( 30340735 )
2018
21
A case of Vogt-Koyanagi-Harada disease as a sequela of drug reaction with eosinophilia and systemic symptoms. ( 30306111 )
2018
22
Vogt-Koyanagi-Harada Disease Associated with Hepatitis B Vaccination. ( 29953303 )
2018
23
Incomplete Vogt-Koyanagi-Harada disease following treatment with encorafenib and binimetinib for metastatic melanoma. ( 30169430 )
2018
24
Vogt-Koyanagi-Harada disease like presentation in patients with chronic myeloid leukemia. ( 29780937 )
2018
25
Unusual Case of Vogt-Koyanagi-Harada Disease Associated with SAPHO Syndrome: A Case Report. ( 29681837 )
2018
26
Association of Long Noncoding RNAs Polymorphisms With Ankylosing Spondylitis, Vogt-Koyanagi-Harada Disease, and Behcet's Disease. ( 29490353 )
2018
27
Longitudinal observation of subretinal fibrosis in Vogt-Koyanagi-Harada disease. ( 29334924 )
2018
28
Vogt-Koyanagi-Harada Disease Associated with Influenza A Virus Infection. ( 29321438 )
2018
29
Recovery of macular cone photoreceptors in Vogt-Koyanagi-Harada disease. ( 29264653 )
2018
30
Corticotherapy vs. Corticotherapy Plus Immunosuppressive Therapy in Acute Vogt-Koyanagi-Harada Disease. ( 29258782 )
2018
31
Multispectral image analysis in Vogt-Koyanagi-Harada disease. ( 29220112 )
2018
32
Differences in photoreceptor recovery among patients and between different parts of the posterior pole in Vogt-Koyanagi-Harada disease. ( 29148525 )
2018
33
Novel treatment regimen of Vogt-Koyanagi-Harada disease with a reduced dose of corticosteroids combined with immunosuppressive agents. ( 29111815 )
2018
34
Unilateral Ocular Manifestations of Vogt-Koyanagi-Harada Disease. ( 29020488 )
2018
35
MicroRNA-20a-5p suppresses IL-17 production by targeting OSM and CCL1 in patients with Vogt-Koyanagi-Harada disease. ( 28972028 )
2018
36
Bilateral Iris Depigmentation and Ocular Hypotony as End-Stage Manifestations of Untreated Vogt-Koyanagi-Harada Disease. ( 28548582 )
2018
37
Photoreceptor Cell Injury Starts in the Initial Stage of Vogt-Koyanagi-Harada Disease. ( 28323511 )
2018
38
Contribution of dual fluorescein and indocyanine green angiography to the appraisal of posterior involvement in birdshot retinochoroiditis and Vogt-Koyanagi-Harada disease. ( 28299496 )
2018
39
The spectrum of Vogt-Koyanagi-Harada disease in Iran. ( 28260142 )
2018
40
SUB-TENON TRIAMCINOLONE ACETONIDE INJECTION IN A PREGNANT PATIENT WITH VOGT-KOYANAGI-HARADA DISEASE. ( 28033228 )
2018
41
Adalimumab Treatment in Patients with Vogt-Koyanagi-Harada Disease. ( 27775450 )
2018
42
Surgical Treatment of Subretinal Fibrosis Caused Macular Detachment in Vogt-Koyanagi-Harada Disease: A Pioneer Study. ( 27494778 )
2018
43
The Role of Optical Coherence Tomography Angiography in the Diagnosis and Management of Acute Vogt-Koyanagi-Harada Disease. ( 27440118 )
2018
44
Rituximab for sight-threatening refractory pediatric Vogt-Koyanagi-Harada disease. ( 26154298 )
2018
45
Predictors of Recurrence in Vogt-Koyanagi-Harada Disease. ( 31047243 )
2018
46
Vogt-Koyanagi-Harada Disease, a Rare Entity in Spain: The Challenge of Worldwide Immigration and Globalization. ( 30756049 )
2018
47
Association Study of ARMC9 Gene Variants with Vogt-Koyanagi-Harada Disease in Japanese Patients. ( 30395750 )
2018
48
Disabled-2 (DAB2) Overexpression Inhibits Monocyte-Derived Dendritic Cells' Function in Vogt-Koyanagi-Harada Disease. ( 30267088 )
2018
49
Optical Coherence Tomography Angiography for Evaluation of Sattler's Layer in Vogt-Koyanagi-Harada Disease. ( 30114311 )
2018
50
Ultra-wide-field angiography findings in acute Vogt-Koyanagi-Harada disease. ( 30100554 )
2018

Variations for Vogt-Koyanagi-Harada Disease

Expression for Vogt-Koyanagi-Harada Disease

Search GEO for disease gene expression data for Vogt-Koyanagi-Harada Disease.

Pathways for Vogt-Koyanagi-Harada Disease

Pathways related to Vogt-Koyanagi-Harada Disease according to GeneCards Suite gene sharing:

(show all 30)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.91 HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10
2
Show member pathways
13.33 HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1 KIR3DL1
3
Show member pathways
13.24 HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10
4
Show member pathways
13.18 FAS IL10 IL17A IL2RA PTPN22 TGFBR3
5
Show member pathways
12.88 HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
6
Show member pathways
12.87 FAS HLA-A HLA-B IL2RA TLR3
7
Show member pathways
12.51 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10 IL2RA
8
Show member pathways
12.45 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10 IL17A IL2RA
9
Show member pathways
12.44 HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
10
Show member pathways
12.39 FAS HLA-A HLA-B KIR3DL1
11
Show member pathways
12.28 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL2RA
12
Show member pathways
12.24 HLA-DQA1 HLA-DQB1 HLA-DRB1 PTPN22
13
Show member pathways
12.16 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10
14 12.13 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10
15
Show member pathways
12.09 HLA-A HLA-B IL10 IL17A IL2RA TGFBR3
16
Show member pathways
12.06 FAS HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
17 12.01 FAS IL10 IL17A IL2RA NLRP1 PTPN22
18 11.97 HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1 IL2RA
19
Show member pathways
11.93 IL10 IL17A TLR3
20 11.9 HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
21
Show member pathways
11.86 HLA-A HLA-DRB1 IL2RA
22
Show member pathways
11.85 HLA-DQA1 HLA-DQB1 HLA-DRB1 PTPN22
23 11.82 HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
24 11.81 HLA-DQA1 HLA-DQB1 HLA-DRB1
25 11.78 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL2RA
26 11.74 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL17A
27 11.68 IL10 IL17A IL2RA
28 11.61 HLA-DQA1 HLA-DQB1 HLA-DRB1 PTPN22
29 11.5 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10
30 10.27 TYR TYRP1

GO Terms for Vogt-Koyanagi-Harada Disease

Cellular components related to Vogt-Koyanagi-Harada Disease according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 Golgi membrane GO:0000139 9.88 HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1 TLR3
2 external side of plasma membrane GO:0009897 9.87 HLA-DRB1 IL17A IL2RA TGFBR3
3 lysosomal membrane GO:0005765 9.85 HLA-DQA1 HLA-DQB1 HLA-DRB1 TLR3
4 cell surface GO:0009986 9.8 FAS HLA-A HLA-B HLA-DRB1 IL2RA TGFBR3
5 endosome membrane GO:0010008 9.77 HLA-DQA1 HLA-DQB1 HLA-DRB1 TLR3 TYRP1
6 melanosome GO:0042470 9.73 PMEL TYR TYRP1
7 trans-Golgi network membrane GO:0032588 9.7 HLA-DQA1 HLA-DQB1 HLA-DRB1
8 endocytic vesicle membrane GO:0030666 9.65 HLA-DQA1 HLA-DQB1 HLA-DRB1
9 transport vesicle membrane GO:0030658 9.61 HLA-DQA1 HLA-DQB1 HLA-DRB1
10 melanosome membrane GO:0033162 9.54 TYR TYRP1
11 MHC class II protein complex GO:0042613 9.5 HLA-DQA1 HLA-DQB1 HLA-DRB1
12 MHC class I protein complex GO:0042612 9.49 HLA-A HLA-B
13 clathrin-coated endocytic vesicle membrane GO:0030669 9.46 HLA-DQA1 HLA-DQB1 HLA-DRB1 TYRP1
14 ER to Golgi transport vesicle membrane GO:0012507 9.35 HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
15 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.02 HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
16 integral component of membrane GO:0016021 10.27 FAS HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
17 integral component of plasma membrane GO:0005887 10.05 HLA-A HLA-B HLA-DQA1 KIR3DL1 PMEL TGFBR3

Biological processes related to Vogt-Koyanagi-Harada Disease according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.86 HLA-A HLA-B HLA-DQA1 HLA-DRB1 IL2RA NLRP1
2 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.73 HLA-DQA1 HLA-DQB1 HLA-DRB1
3 T cell receptor signaling pathway GO:0050852 9.71 HLA-DQA1 HLA-DQB1 HLA-DRB1 PTPN22
4 negative regulation of T cell proliferation GO:0042130 9.63 HLA-DRB1 IL10 IL2RA
5 melanosome organization GO:0032438 9.57 PMEL TYRP1
6 inflammatory response to antigenic stimulus GO:0002437 9.55 HLA-DRB1 IL2RA
7 interferon-gamma-mediated signaling pathway GO:0060333 9.55 HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
8 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.54 HLA-A HLA-B
9 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.54 HLA-DQA1 HLA-DQB1 HLA-DRB1
10 antigen processing and presentation of endogenous peptide antigen via MHC class Ib GO:0002476 9.52 HLA-A HLA-B
11 necroptotic signaling pathway GO:0097527 9.51 FAS TLR3
12 melanin biosynthetic process GO:0042438 9.5 PMEL TYR TYRP1
13 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.49 HLA-DQB1 HLA-DRB1
14 protection from natural killer cell mediated cytotoxicity GO:0042270 9.48 HLA-A HLA-B
15 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.43 HLA-DQB1 HLA-DRB1
16 immune response GO:0006955 9.36 FAS HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
17 antigen processing and presentation GO:0019882 9.35 HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1

Molecular functions related to Vogt-Koyanagi-Harada Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MHC class II receptor activity GO:0032395 9.13 HLA-DQA1 HLA-DQB1 HLA-DRB1
2 peptide antigen binding GO:0042605 9.02 HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1

Sources for Vogt-Koyanagi-Harada Disease

3 CDC
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75 UMLS via Orphanet
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