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MCID: VGT001
MIFTS: 55

Vogt-Koyanagi-Harada Disease

Categories: Eye diseases, Immune diseases, Neuronal diseases, Rare diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Vogt-Koyanagi-Harada Disease

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MalaCards integrated aliases for Vogt-Koyanagi-Harada Disease:

Name: Vogt-Koyanagi-Harada Disease 12 52 58 29 54 15
Uveomeningoencephalitic Syndrome 12 43 71
Vogt-Koyanagi-Harada Syndrome 52 36
Uveomenigitic Syndrome 52 58
Vogt-Koyanagi Syndrome 12
Harada's Disease 12
Vkh Syndrome 52
Vkh Disease 52

Characteristics:

Orphanet epidemiological data:

58
vogt-koyanagi-harada disease
Inheritance: Multigenic/multifactorial; Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Neuronal diseases Eye diseases Immune diseases Skin diseases
See all MalaCards categories (disease lists)
ICD10: 33
Orphanet: 58  
Rare neurological diseases
Rare eye diseases


External Ids:

Disease Ontology 12 DOID:12297
KEGG 36 H01504
ICD9CM 34 364.24
MeSH 43 D014607
NCIt 49 C85218
SNOMED-CT 67 193497004
ICD10 32 H20.82
ICD10 via Orphanet 33 H20.8 H30.8
UMLS via Orphanet 72 C0042170
Orphanet 58 ORPHA3437
UMLS 71 C0042170
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Summaries for Vogt-Koyanagi-Harada Disease

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NIH Rare Diseases : 52 Vogt-Koyanagi-Harada disease (VKH disease) is a disease that affects several parts of the body, including the eyes, ears, nervous system, and skin. The signs and symptoms of VKH disease are caused by chronic inflammation of melanocytes. Melanocytes are specialized cells that produce a pigment called melanin . Melanin is the substance that gives skin, hair, and eyes their color. Melanin is also found in other parts of the body, such as the retina of the eyes, where it plays a role in normal vision, and in the inner ear, where it is thought to be involved in hearing. People with VKH disease usually develop vision and hearing problems first, followed by signs of skin problems. The most common symptoms include headaches, inflammation of all layers of the colored part of the eye (panuveitis ), white patches of skin (vitiligo ), hair loss (alopecia ), dizziness and nausea (inner ear related problems), and vision and hearing loss . Neurological symptoms may also occur. The exact cause of VKH disease is not well understood, but research suggests it is an autoimmune disease . It is more common in people with darker skin color including Asian, Middle Eastern, Hispanic, and Native American populations. The disease is treated with corticosteroids and other medications.

MalaCards based summary : Vogt-Koyanagi-Harada Disease, also known as uveomeningoencephalitic syndrome, is related to iridocyclitis and choroiditis. An important gene associated with Vogt-Koyanagi-Harada Disease is PTPN22 (Protein Tyrosine Phosphatase Non-Receptor Type 22), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. The drugs Bevacizumab and Angiogenesis Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and retina, and related phenotypes are sensorineural hearing impairment and cognitive impairment

Disease Ontology : 12 An autoimmune hypersensitivity disease that is caused by T helper cell mediated autoimmune attack of melanocytes resulting in inflammation of the inside of the eye, whitening of hair, skin pigment loss, and meningitis.

KEGG : 36 Vogt-Koyanagi-Harada syndrome (VKHS), initially described as an uveomeningoencephalitic syndrome, is a rare systemic autoimmune disease that targets melanocyte-rich tissues, such as the eye, inner ear, meninges, skin and hair. This disease is characterized by panuveitis, often associated with neurologic and cutaneous manifestations, including headache, hearing loss, vitiligo, and poliosis. VKHS is more common in individuals of pigmented skin, such as Asians, Middle Easterners, Hispanics and Native Americans. Although the exact etiology of VKHS remains unclear, it has also been postulated that such an autoimmune response might be triggered by an infectious agent in a genetically susceptible individual. Several studies have demonstrated that HLA-DR4 is strongly associated with VKHD.

Wikipedia : 74 Vogt-Koyanagi-Harada disease (VKH) is a multisystem disease of presumed autoimmune cause that affects... more...

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Related Diseases for Vogt-Koyanagi-Harada Disease

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Diseases related to Vogt-Koyanagi-Harada Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 466)
# Related Disease Score Top Affiliating Genes
1 iridocyclitis 32.1 IL17A IL10 HLA-B
2 choroiditis 32.0 IL17A IL10 IFNG
3 sympathetic ophthalmia 32.0 IL10 HLA-DRB1 HLA-DQA1
4 pars planitis 31.8 HLA-DRB1 HLA-B HLA-A
5 panuveitis 31.8 IL17A IL10 HLA-DRB1 HLA-DQB1 HLA-B CD8A
6 uveitis 31.7 PMEL IL2RA IL17A IL10 IFNG HLA-B
7 optic neuritis 31.6 IL2RA IL10 HLA-DRB1
8 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 31.3 PTPN22 IL17A IL10 IFNG
9 vitiligo-associated multiple autoimmune disease susceptibility 1 31.3 TYRP1 TYR PTPN22 PMEL NLRP1 HLA-B
10 halo nevi 31.3 TYR PMEL HLA-DRB1
11 primary adrenal insufficiency 31.2 HLA-DRB1 HLA-DQB1 HLA-DQA1
12 chickenpox 31.2 IL10 IFNG CD8A
13 meningitis 31.2 IL17A IL10 IFNG HLA-B
14 iritis 31.1 IL17A HLA-B CD8A
15 chorioretinitis 31.1 IL17A IL10 IFNG CD8A
16 hypopyon 31.1 IL17A IL10 HLA-B
17 relapsing polychondritis 31.1 IL17A IL10 IFNG
18 ulcerative colitis 31.0 IL17A IL10 IFNG HLA-DRB1
19 autoimmune uveitis 31.0 IL17A IL10 IFNG
20 conjunctivitis 31.0 IL10 IFNG HLA-B
21 brucellosis 31.0 IL17A IL10 IFNG
22 eye disease 30.9 TYR IL17A IL10 IFNG CD8A
23 intermediate uveitis 30.9 IL2RA IL10 IFNG HLA-DRB1 HLA-B
24 proteasome-associated autoinflammatory syndrome 1 30.9 IL17A IL10 IFNG
25 colitis 30.9 IL17A IL10 IFNG HLA-DRB1
26 fungal meningitis 30.9 IL17A IL10 IFNG CD8A
27 sarcoidosis 1 30.9 IL2RA IFNG HLA-DRB1 HLA-DQB1 HLA-A CD8A
28 systemic scleroderma 30.8 IL17A IL10 IFNG CD8A
29 spondylitis 30.8 IL17A IL10 IFNG HLA-B
30 crohn's disease 30.7 PTPN22 IL17A IL10 IFNG HLA-DRB1
31 demyelinating disease 30.7 IL17A IL10 IFNG HLA-DRB1 CD8A
32 reactive arthritis 30.6 IL17A IL10 IFNG HLA-DRB1 HLA-B
33 measles 30.6 IL2RA IFNG HLA-DRB1 HLA-DQA1 HLA-A
34 guillain-barre syndrome 30.6 HLA-DRB1 HLA-DQB1 HLA-DQA1 FAS
35 autoimmune pancreatitis 30.6 IL17A IL10 HLA-DRB1
36 herpes zoster 30.6 IL10 IFNG HLA-DRB1 HLA-B HLA-A CD8A
37 myasthenia gravis 30.6 PTPN22 IL10 IFNG HLA-DQB1 HLA-B
38 bone inflammation disease 30.5 PTPN22 IL17A IL10 IFNG HLA-DRB1 CD8A
39 viral hepatitis 30.5 IL10 IFNG HLA-DRB1 HLA-DQA1 FAS
40 toxoplasmosis 30.5 NLRP1 IL10 IFNG HLA-DQB1 HLA-DQA1
41 syphilis 30.4 IL17A IFNG HLA-DRB1 FAS CD8A
42 skin disease 30.4 TYR IL17A IL10 IFNG HLA-B CD8A
43 rubella 30.1 IL2RA IL10 IFNG HLA-DRB1 HLA-DQB1 HLA-DQA1
44 immune deficiency disease 29.9 IL2RA IL10 IFNG HLA-B HLA-A FAS
45 psoriasis 29.9 PTPN22 KIR3DL1 IL2RA IL17A IL10 IFNG
46 multiple sclerosis 29.8 PTPN22 IL2RA IL17A IL10 IFNG HLA-DRB1
47 autoimmune disease 29.6 PTPN22 NLRP1 IL2RA IL17A IL10 IFNG
48 common variable immunodeficiency 29.6 IL2RA IL10 IFNG HLA-DRB1 HLA-DQB1 HLA-B
49 arthritis 29.6 PTPN22 NLRP1 IL17A IL10 IFNG HLA-DRB1
50 alopecia areata 29.5 PTPN22 IL2RA IL17A IL10 IFNG HLA-DRB1

Graphical network of the top 20 diseases related to Vogt-Koyanagi-Harada Disease:



Diseases related to Vogt-Koyanagi-Harada Disease
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Symptoms & Phenotypes for Vogt-Koyanagi-Harada Disease

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Human phenotypes related to Vogt-Koyanagi-Harada Disease:

58 31 (show all 16)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 sensorineural hearing impairment 58 31 hallmark (90%) Very frequent (99-80%) HP:0000407
2 cognitive impairment 58 31 hallmark (90%) Very frequent (99-80%) HP:0100543
3 hypopigmented skin patches 58 31 hallmark (90%) Very frequent (99-80%) HP:0001053
4 vitiligo 58 31 hallmark (90%) Very frequent (99-80%) HP:0001045
5 premature graying of hair 58 31 hallmark (90%) Very frequent (99-80%) HP:0002216
6 sparse scalp hair 58 31 hallmark (90%) Very frequent (99-80%) HP:0002209
7 poliosis 58 31 hallmark (90%) Very frequent (99-80%) HP:0002290
8 abnormal eyelash morphology 31 hallmark (90%) HP:0000499
9 abnormal eyebrow morphology 31 hallmark (90%) HP:0000534
10 cataract 58 31 frequent (33%) Frequent (79-30%) HP:0000518
11 visual impairment 58 31 frequent (33%) Frequent (79-30%) HP:0000505
12 short stature 58 31 frequent (33%) Frequent (79-30%) HP:0004322
13 glaucoma 58 31 frequent (33%) Frequent (79-30%) HP:0000501
14 retinal detachment 58 31 frequent (33%) Frequent (79-30%) HP:0000541
15 abnormality of the eyelashes 58 Very frequent (99-80%)
16 abnormality of the eyebrow 58 Very frequent (99-80%)

GenomeRNAi Phenotypes related to Vogt-Koyanagi-Harada Disease according to GeneCards Suite gene sharing:

26 (show all 38)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-102 10.25 KIR3DL3
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-103 10.25 HLA-A HLA-B
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-110 10.25 HLA-A HLA-B
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-119 10.25 KIR3DL3
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 10.25 KIR3DL3
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-152 10.25 KIR3DL3
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-156 10.25 HLA-A HLA-B
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-178 10.25 HLA-A HLA-B
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-19 10.25 HLA-A HLA-B
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-190 10.25 KIR3DL3
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-202 10.25 KIR3DL3
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-211 10.25 KIR3DL3
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 10.25 KIR3DL3
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-31 10.25 HLA-A HLA-B KIR3DL3
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-7 10.25 HLA-A HLA-B
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-73 10.25 KIR3DL3
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-79 10.25 KIR3DL3
18 Increased shRNA abundance (Z-score > 2) GR00366-A-104 9.98 IL2RA
19 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.98 HLA-DQA1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.98 IL2RA
21 Increased shRNA abundance (Z-score > 2) GR00366-A-118 9.98 HLA-A HLA-B
22 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.98 IL2RA
23 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.98 IL2RA
24 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.98 IL2RA
25 Increased shRNA abundance (Z-score > 2) GR00366-A-174 9.98 IL2RA
26 Increased shRNA abundance (Z-score > 2) GR00366-A-193 9.98 HLA-DQA1
27 Increased shRNA abundance (Z-score > 2) GR00366-A-202 9.98 IL2RA
28 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.98 IL2RA
29 Increased shRNA abundance (Z-score > 2) GR00366-A-34 9.98 IL2RA
30 Increased shRNA abundance (Z-score > 2) GR00366-A-45 9.98 HLA-DQA1
31 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.98 IL2RA
32 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.98 IL2RA
33 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.98 IL2RA
34 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.98 HLA-DQA1
35 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.98 HLA-A HLA-B
36 Increased shRNA abundance (Z-score > 2) GR00366-A-98 9.98 HLA-DQA1
37 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.44 FAS IL10 IL17A IL2RA NLRP1 PMEL
38 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.44 FAS HLA-DQB1 IL10 IL17A IL2RA NLRP1

MGI Mouse Phenotypes related to Vogt-Koyanagi-Harada Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.9 CD8A FAS HLA-A HLA-DQA1 HLA-DQB1 IFNG
2 hematopoietic system MP:0005397 9.77 CD8A FAS HLA-A HLA-DQA1 HLA-DQB1 IFNG
3 immune system MP:0005387 9.4 CD8A FAS HLA-A HLA-DQA1 HLA-DQB1 IFNG
Sources

Drugs & Therapeutics for Vogt-Koyanagi-Harada Disease

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Drugs for Vogt-Koyanagi-Harada Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 3 216974-75-3
2 Angiogenesis Inhibitors Phase 3
3 Antineoplastic Agents, Immunological Phase 3
4
Iodine Approved, Investigational 7553-56-2 807
5
Mycophenolic acid Approved 24280-93-1 446541
6
Povidone Approved 9003-39-8
7
Povidone-iodine Approved 25655-41-8
8
Azathioprine Approved 446-86-6 2265
9
Methylprednisolone Approved, Vet_approved 83-43-2 6741
10
Prednisone Approved, Vet_approved 53-03-2 5865
11
Prednisolone phosphate Approved, Vet_approved 302-25-0
12
Methylprednisolone hemisuccinate Approved 2921-57-5
13
Prednisolone Approved, Vet_approved 50-24-8 5755
14 Prednisolone acetate Approved, Vet_approved 52-21-1
15
Dexamethasone acetate Approved, Investigational, Vet_approved 1177-87-3
16
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 5743
17
Prednisolone hemisuccinate Experimental 2920-86-7
18 Immunosuppressive Agents
19 Cyclosporins
20 Anti-Bacterial Agents
21 Antibiotics, Antitubercular
22 cadexomer iodine
23 Immunologic Factors
24 Hormones
25 Antineoplastic Agents, Hormonal
26 Methylprednisolone Acetate
27 Hormone Antagonists
28 glucocorticoids
29 Anti-Inflammatory Agents
30 Antiemetics
31 Gastrointestinal Agents
32 BB 1101

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Intravitreal Bevacizumab for the Treatment of Neovascular Membranes in Patients With Intraocular Inflammation Completed NCT00407121 Phase 3 Bevacizumab
2 Intravitreal Bevacizumab for the Treatment of Choroidal Neovascularization in Vogt-Koyanagi-Harada Disease - A Prospective Study Unknown status NCT02015351 bevacizumab
3 Influência de imunomodulação Precoce Influence of Early Immunosuppressive Therapy on the Course of Vogt-Koyanagi-Harada Disease: a Prospective Study Unknown status NCT03399175 Early high-dose corticosteroid and immunosuppressive therapy
4 Multimodal Analysis and Electroretinogram in VKH From Acute Onset - a Prospective Study Completed NCT03811366 Meticorten
5 Long Term Efficacy of Dexamethasone Intravitreal Implant (Ozurdex®) in Treatment of Recurrent VKH Uveitis Completed NCT03971279 Dexamethasone Ophthalmic implant
6 Using Next-Generation Sequencing Technology to Identify Biomarkers of Common Eye Diseases Recruiting NCT04101604
7 Clinical Observational Research on Changes of Peripheral Blood Mononuclear Cell（PBMC） Immunity and Expression Profile in Peripheral Blood of Different Course of of Vogt-Hoyanagi-Harada（VKH） Patients. Recruiting NCT04025476 Steroids
8 Pilot Project: The Amplicon and Metatranscriptomic Next-generation Sequencing of Samples From Intra and Extra-intestinal Microbiome in Non-infectious Uveitis Patients to Decipher Possibility Uveitis Pathogenesis Not yet recruiting NCT04126850
9 Subfoveal Choroidal Thickness in Thai Population Terminated NCT02551601

Search NIH Clinical Center for Vogt-Koyanagi-Harada Disease

Cochrane evidence based reviews: uveomeningoencephalitic syndrome

Sources

Genetic Tests for Vogt-Koyanagi-Harada Disease

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Genetic tests related to Vogt-Koyanagi-Harada Disease:

# Genetic test Affiliating Genes
1 Vogt-Koyanagi-Harada Disease 29
Sources

Anatomical Context for Vogt-Koyanagi-Harada Disease

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MalaCards organs/tissues related to Vogt-Koyanagi-Harada Disease:

40
Eye, Skin, Retina, T Cells, Myeloid, Brain, Spinal Cord
Sources

Publications for Vogt-Koyanagi-Harada Disease

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Articles related to Vogt-Koyanagi-Harada Disease:

(show top 50) (show all 722)
# Title Authors PMID Year
1
Earlier immunomodulatory treatment is associated with better visual outcomes in a subset of patients with Vogt-Koyanagi-Harada disease. 52 61
25565265 2015
2
Vogt-koyanagi-harada syndrome. 52
18600484 2008
3
Expression of Fas antigen on helper T lymphocytes in Vogt-Koyanagi-Harada disease. 61 54
9646088 1998
4
Tyrosinase epitope recognized by an HLA-DR-restricted T-cell line from a Vogt-Koyanagi-Harada disease patient. 54 61
9510558 1998
5
Apoptosis-related fas antigen on memory T cells in aqueous humor of uveitis patients. 61 54
8654110 1996
6
Influence of HLA-DRB1 gene variation on the clinical course of Vogt-Koyanagi-Harada disease. 54 61
7906684 1994
7
Characterization of T-cell subsets, soluble interleukin-2 receptors and interleukin-6 in Vogt-Koyanagi-Harada disease. 61 54
1635294 1992
8
Plasma metabolomics study of Vogt-Koyanagi-Harada disease identifies potential diagnostic biomarkers. 61
32439397 2020
9
TATTOO-ASSOCIATED CASES OF POSTERIOR SEGMENT UVEITIS WITH VOGT-KOYANAGI-HARADA DISEASE-LIKE FEATURES. 61
32502130 2020
10
[Changes of retinal structure after systemic immunosuppressive treatment in eyes with Vogt-Koyanagi-Harada disease]. 61
32536094 2020
11
Integrated omics analysis of sweat reveals an aberrant amino acid metabolism pathway in Vogt-Koyanagi-Harada disease. 61
32222072 2020
12
Assessment of macular capillary perfusion in patients with inactive Vogt-Koyanagi-Harada disease: an optical coherence tomography angiography study. 61
32363500 2020
13
The Rs12569232 SNP Association with Vogt-Koyanagi-Harada Disease and Behcet's Disease is Probably Mediated by Regulation of Linc00467 Expression. 61
32400232 2020
14
Optic Disc Neovascularization in Tubercular Serpiginous-Like Choroiditis. 61
31403829 2020
15
Clinical and therapeutic features of pediatric Vogt-Koyanagi-Harada disease. 61
32115269 2020
16
Concurrent Vogt-Koyanagi-Harada disease and impressive response to immune checkpoint blockade in metastatic melanoma. 61
32308086 2020
17
CHOROIDAL GRANULOMAS VISUALIZED BY SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY. 61
32467485 2020
18
Activation of the interleukin-23/interleukin-17 signalling pathway in autoinflammatory and autoimmune uveitis. 61
32422390 2020
19
Retinal Microcirculation Defects on OCTA Correlate with Active Inflammation and Vision in Vogt-Koyanagi-Harada Disease. 61
32407159 2020
20
Altered gut microbiome composition in patients with Vogt-Koyanagi-Harada disease. 61
31928124 2020
21
Vogt-Koyanagi-Harada disease: recurrence rates after initial-onset disease differ according to treatment modality and geographic area. 61
32418076 2020
22
Self-Reported Quality of Life in Patients with Long-Standing Vogt-Koyanagi-Harada Disease. 61
31136253 2020
23
Vogt-Koyanagi-Harada disease during chemoimmunotherapy for non-small cell lung cancer. 61
32128216 2020
24
Efficacy of Adalimumab for Chronic Vogt-Koyanagi-Harada Disease Refractory to Conventional Corticosteroids and Immunosuppressive Therapy and Complicated by Central Serous Chorioretinopathy. 61
31268769 2020
25
Optical coherence tomography diagnostic signs in posterior uveitis. 61
31513851 2020
26
Prevalence and clinical features of systemic diseases in Chinese patients with uveitis. 61
32188681 2020
27
Retinal vascular inflammatory and occlusive changes in infectious and non-infectious uveitis. 61
32016664 2020
28
Management of recalcitrant vitiligo in Vogt-Koyanagi-Harada syndrome: Adjuvant ablative fractional laser. 61
32131141 2020
29
Pseudo-inflammatory manifestations of choroidal lymphoma resembling Vogt-Koyanagi-Harada disease: case report based on multimodal imaging. 61
32156266 2020
30
Headache and Bilateral Optic Disc Edema as the Initial Manifestation of Vogt-Koyanagi-Harada Disease. 61
32102009 2020
31
Changes in Etiology of Uveitis in a Single Center in Japan. 61
32068467 2020
32
Lord Nelson's (1758-1805) left eye. 61
28972425 2020
33
A Case of Recurrent Vogt-Koyanagi-Harada Disease Successfully Treated with Adalimumab in Young Female Adult Patient. 61
32037756 2020
34
Chronological changes of the anterior chamber structure, axial length, and refraction in patients with Vogt-Koyanagi-Harada disease. 61
31973595 2020
35
Rare association between Vogt-Koyanagi-Harada disease and rheumatoid arthritis: Report of a clinical case from the unit of multidisciplinary uveitis. 61
29519769 2020
36
Inflammatory Choroidal Neovascular Membranes in Patients With Noninfectious Uveitis: The Place of Intravitreal Anti-VEGF Therapy. 61
32490018 2020
37
Variants in IL23R-C1orf141 and ADO-ZNF365-EGR2 are associated with susceptibility to Vogt-Koyanagi-Harada disease in Japanese population. 61
32437414 2020
38
Pigmented paravenous retinochoroidal atrophy associated with Vogt-Koyanagi-Harada disease: a case report. 61
31996165 2020
39
Multimodal Imaging of Annular Choroidal Detachment in a Patient with Vogt-Koyanagi-Harada Disease. 61
31951785 2020
40
A Case of Pneumatic Displacement with Gas Tamponade Performed for Macular Subretinal Hemorrhage Complicating Vogt-Koyanagi-Harada Disease. 61
32308616 2020
41
Bilateral serous retinal detachment associated with subretinal fibrin-like material in a case of pregnancy-induced hypertension. 61
31788578 2019
42
Retinal vessel oxygen saturation is affected in uveitis associated with Vogt-Koyanagi-Harada disease. 61
30798260 2019
43
Presumed atypical peripapillary Vogt-Koyanagi-Harada disease. 61
31517139 2019
44
Anesthesia for a patient with Vogt-Koyanagi-Harada disease. 61
31377671 2019
45
Outcomes of Intravitreal Bevacizumab in Choroidal Neovascularization in Vogt-Koyanagi-Harada Disease - A Prospective Study. 61
31746659 2019
46
[Systemic biological treatment in ophthalmology]. 61
31657252 2019
47
Replication of Genome-Wide Association Analysis Identifies New Susceptibility Loci at Long Noncoding RNA Regions for Vogt-Koyanagi-Harada Disease. 61
31747682 2019
48
Correlation between visual acuity and human leukocyte antigen DRB1*04 in patients with Vogt-Koyanagi-Harada disease. 61
31699055 2019
49
Glucocorticoid Receptor-α and MKP-1 as Candidate Biomarkers for Treatment Response and Disease Activity in Vogt-Koyanagi-Harada Disease. 61
31323199 2019
50
Full-field electroretinogram behavior in Vogt-Koyanagi-Harada disease: a 24-month longitudinal study in patients from acute onset evaluated with multimodal analysis. 61
31440820 2019
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Variations for Vogt-Koyanagi-Harada Disease

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Expression for Vogt-Koyanagi-Harada Disease

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Search GEO for disease gene expression data for Vogt-Koyanagi-Harada Disease.
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Pathways for Vogt-Koyanagi-Harada Disease

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Pathways related to Vogt-Koyanagi-Harada Disease according to GeneCards Suite gene sharing:

(show all 39)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 13.97 PTPN22 NLRP1 KIR3DL2 KIR3DL1 IL2RA IL17A
2
Class I MHC mediated antigen processing and presentation 65
Show member pathways
 13.45 PTPN22 KIR3DL2 KIR3DL1 HLA-DRB1 HLA-DQB1 HLA-DQA1
3
Cytokine Signaling in Immune system 65
Show member pathways
 13.36 IL2RA IL17A IL10 IFNG HLA-DRB1 HLA-DQB1
4
Actin Nucleation by ARP-WASP Complex 63
Show member pathways
 12.91 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-B HLA-A
5
Herpes simplex virus 1 infection 36
12.78 IFNG HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-B HLA-A
6
Immune response NFAT in immune response 22
Show member pathways
 12.65 IL2RA IL10 IFNG HLA-DRB1 HLA-DQB1 HLA-DQA1
7
Measles 36
Show member pathways
 12.63 IL2RA IFNG HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-B
8
T cell receptor signaling pathway 36
Show member pathways
 12.6 IL17A IL10 IFNG FAS CD8A
9
Interferon gamma signaling 65
Show member pathways
 12.54 IFNG HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-B HLA-A
10
Th17 cell differentiation 36
Show member pathways
 12.51 IL2RA IL17A IL10 IFNG HLA-DRB1 HLA-DQB1
11
ICos-ICosL Pathway in T-Helper Cell 63
Show member pathways
 12.36 IL2RA HLA-DRB1 HLA-DQB1 HLA-DQA1
12
TCR signaling (REACTOME) 65
Show member pathways
 12.32 PTPN22 HLA-DRB1 HLA-DQB1 HLA-DQA1
13
Human T-cell leukemia virus 1 infection 36
12.31 IL2RA HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-B HLA-A
14
Toxoplasmosis 36
Show member pathways
 12.29 IL10 IFNG HLA-DRB1 HLA-DQB1 HLA-DQA1
15
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.28 IL2RA IL17A IL10 IFNG HLA-B HLA-A
16
Immune response Role of DAP12 receptors in NK cells 22
Show member pathways
 12.28 KIR3DL3 KIR3DL2 KIR3DL1 IFNG HLA-B HLA-A
17
Tuberculosis 36
12.26 IL10 IFNG HLA-DRB1 HLA-DQB1 HLA-DQA1
18
Allograft rejection 1 36
Show member pathways
 12.21 KIR3DL3 KIR3DL2 KIR3DL1 IL2RA IL17A IL10
19
Phagosome 36
12.16 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-B HLA-A
20
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 65
12.09 KIR3DL2 KIR3DL1 HLA-B HLA-A CD8A
21
NF-kappaB Signaling 4
12.07 PTPN22 NLRP1 IL2RA IL17A IL10 IFNG
22
Hematopoietic Stem Cells and Lineage-specific Markers 64
12.01 IL2RA IL10 IFNG CD8A
23
IL12-mediated signaling events 1
Show member pathways
 11.98 IL2RA IFNG HLA-DRB1 HLA-A CD8A
24
Translocation of ZAP-70 to Immunological synapse 65
Show member pathways
 11.97 PTPN22 HLA-DRB1 HLA-DQB1 HLA-DQA1
25
Staphylococcus aureus infection 36
11.91 IL10 HLA-DRB1 HLA-DQB1 HLA-DQA1
26
Hematopoietic cell lineage 36
11.87 IL2RA HLA-DRB1 HLA-DQB1 HLA-DQA1 CD8A
27
Rheumatoid arthritis 36
11.82 IL17A IFNG HLA-DRB1 HLA-DQB1 HLA-DQA1
28
Cell adhesion molecules (CAMs) 36
11.8 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-B HLA-A CD8A
29
G-protein signaling N-RAS regulation pathway 22
Show member pathways
 11.79 HLA-DRB1 HLA-DQB1 HLA-DQA1
30
Dendritic Cells Developmental Lineage Pathway 64
11.72 IL10 IFNG CD8A
31
Innate Lymphoid Cells Differentiation 64
11.71 IL2RA IL17A IL10 IFNG CD8A
32
Downstream signaling in naive CD8+ T cells 1
Show member pathways
 11.67 IL2RA IFNG HLA-A CD8A
33
CTLA4 Signaling 63
11.62 PTPN22 HLA-DRB1 HLA-DQB1 HLA-DQA1 CD8A
34
Th2 Differentiation 64
11.5 IL2RA IL10 IFNG
35
African trypanosomiasis 36
11.4 IL10 IFNG FAS
36
IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types 64
Show member pathways
 11.37 IL2RA IL10 IFNG FAS
37
Cytokines and Inflammatory Response 1
11.28 IL10 IFNG HLA-DRB1
38
IL12 signaling mediated by STAT4 1
11.26 IL2RA IFNG HLA-DRB1
39
Melanin biosynthesis 65
10.36 TYRP1 TYR
Sources

GO Terms for Vogt-Koyanagi-Harada Disease

About this section

Cellular components related to Vogt-Koyanagi-Harada Disease according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 10.17 TYRP1 TYR PMEL KIR3DL3 KIR3DL2 KIR3DL1
2 integral component of plasma membrane GO:0005887 9.97 PMEL KIR3DL2 KIR3DL1 HLA-DRB1 HLA-DQA1 HLA-B
3 external side of plasma membrane GO:0009897 9.83 IL2RA IL17A HLA-DRB1 FAS CD8A
4 endosome membrane GO:0010008 9.8 TYRP1 HLA-DRB1 HLA-DQB1 HLA-DQA1
5 melanosome GO:0042470 9.71 TYRP1 TYR PMEL
6 trans-Golgi network membrane GO:0032588 9.69 HLA-DRB1 HLA-DQB1 HLA-DQA1
7 endocytic vesicle membrane GO:0030666 9.63 HLA-DRB1 HLA-DQB1 HLA-DQA1
8 transport vesicle membrane GO:0030658 9.58 HLA-DRB1 HLA-DQB1 HLA-DQA1
9 melanosome membrane GO:0033162 9.52 TYRP1 TYR
10 MHC class I protein complex GO:0042612 9.48 HLA-B HLA-A
11 clathrin-coated endocytic vesicle membrane GO:0030669 9.46 TYRP1 HLA-DRB1 HLA-DQB1 HLA-DQA1
12 MHC class II protein complex GO:0042613 9.43 HLA-DRB1 HLA-DQB1 HLA-DQA1
13 ER to Golgi transport vesicle membrane GO:0012507 9.35 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-B HLA-A
14 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.02 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-B HLA-A

Biological processes related to Vogt-Koyanagi-Harada Disease according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 adaptive immune response GO:0002250 9.93 IFNG HLA-DRB1 HLA-DQA1 HLA-B HLA-A CD8A
2 immune system process GO:0002376 9.86 PTPN22 NLRP1 IL2RA HLA-DRB1 HLA-DQA1 HLA-B
3 regulation of immune response GO:0050776 9.83 KIR3DL2 KIR3DL1 HLA-B HLA-A CD8A
4 T cell receptor signaling pathway GO:0050852 9.8 PTPN22 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-A
5 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.78 HLA-DRB1 HLA-DQB1 HLA-DQA1
6 negative regulation of T cell proliferation GO:0042130 9.7 IL2RA IL10 HLA-DRB1
7 interferon-gamma-mediated signaling pathway GO:0060333 9.63 IFNG HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-B HLA-A
8 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.6 HLA-DRB1 HLA-DQA1
9 positive regulation of MHC class II biosynthetic process GO:0045348 9.59 IL10 IFNG
10 positive regulation of interleukin-1 beta biosynthetic process GO:0050725 9.58 IL17A IFNG
11 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.58 HLA-B HLA-A
12 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent GO:0002486 9.57 HLA-B HLA-A
13 protection from natural killer cell mediated cytotoxicity GO:0042270 9.56 HLA-B HLA-A
14 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.55 HLA-DRB1 HLA-DQB1
15 positive regulation of interleukin-23 production GO:0032747 9.54 IL17A IFNG
16 melanin biosynthetic process GO:0042438 9.54 TYRP1 TYR PMEL
17 positive regulation of CD8-positive, alpha-beta T cell proliferation GO:2000566 9.51 PTPN22 HLA-A
18 detection of bacterium GO:0016045 9.5 HLA-DRB1 HLA-B HLA-A
19 activation-induced cell death of T cells GO:0006924 9.49 IL2RA FAS
20 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.48 HLA-DRB1 HLA-DQB1
21 antigen processing and presentation GO:0019882 9.43 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-B HLA-A CD8A
22 immune response GO:0006955 9.4 KIR3DL1 IL2RA IL17A IL10 IFNG HLA-DRB1

Molecular functions related to Vogt-Koyanagi-Harada Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.13 TYRP1 TYR PTPN22 PMEL NLRP1 KIR3DL2
2 TAP binding GO:0046977 9.32 HLA-B HLA-A
3 monophenol monooxygenase activity GO:0004503 9.26 TYRP1 TYR
4 MHC class II receptor activity GO:0032395 9.13 HLA-DRB1 HLA-DQB1 HLA-DQA1
5 peptide antigen binding GO:0042605 9.02 HLA-DRB1 HLA-DQB1 HLA-DQA1 HLA-B HLA-A
Sources

Sources for Vogt-Koyanagi-Harada Disease

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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