Vogt-Koyanagi-Harada Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: VGT001 MIFTS: 60	Vogt-Koyanagi-Harada Disease Categories: Rare diseases, Neuronal diseases, Eye diseases, Immune diseases
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Aliases & Classifications for Vogt-Koyanagi-Harada Disease

MalaCards integrated aliases for Vogt-Koyanagi-Harada Disease:

Name: Vogt-Koyanagi-Harada Disease ¹² ⁵³ ⁵⁹ ⁵⁵ ¹⁵

Uveomeningoencephalitic Syndrome ¹² ⁴⁴ ⁷³

Vogt-Koyanagi-Harada Syndrome ⁵³ ³⁷

Uveomenigitic Syndrome ⁵³ ⁵⁹

Vogt-Koyanagi Syndrome ¹²

Harada's Disease ¹²

Vkh Syndrome ⁵³

Vkh Disease ⁵³

Characteristics:

Orphanet epidemiological data:

⁵⁹

vogt-koyanagi-harada disease
Inheritance: Multigenic/multifactorial; Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Neuronal diseases Eye diseases Immune diseases

See all MalaCards categories (disease lists)

ICD10: ³⁴

Diseases of the eye and adnexa

Disorders of choroid and retina

Chorioretinal inflammation

Other chorioretinal inflammations

Disorders of sclera, cornea, iris and ciliary body

Iridocyclitis

Other iridocyclitis

Orphanet: ⁵⁹

Rare neurological diseases

Rare eye diseases

External Ids:

Disease Ontology ¹² DOID:12297

ICD10 ³³ H20.82 H30.81

ICD9CM ³⁵ 363.22 364.24

MeSH ⁴⁴ D014607

NCIt ⁵⁰ C85218

SNOMED-CT ⁶⁸ 193453003 193497004 44923005 more

Orphanet ⁵⁹ ORPHA3437

ICD10 via Orphanet ³⁴ H20.8 H30.8

UMLS via Orphanet ⁷⁴ C0042170

KEGG ³⁷ H01504

SNOMED-CT via HPO ⁶⁹ 60700002 23986001 246635007 more

UMLS ⁷³ C0042170

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Summaries for Vogt-Koyanagi-Harada Disease

NIH Rare Diseases : ⁵³ Vogt-Koyanagi-Harada disease (VKH disease) is a disease that affects several parts of the body, including the eyes, ears, nervous system, and skin. The signs and symptoms of VKH disease are caused by chronic inflammation of melanocytes. Melanocytes are specialized cells that produce a pigment called melanin. Melanin is the substance that gives skin, hair, and eyes their color. Melanin is also found in other parts of the body, such as the retina of the eyes, where it plays a role in normal vision, and in the inner ear, where it is thought to be involved in hearing. People with VKH disease usually develop vision and hearing problems first, followed by signs of skin problems. The most common symptoms include headaches, inflammation of all layers of the colored part of the eye (panuveitis), white patches of skin (vitiligo), hair loss (alopecia), dizziness and nausea (inner ear related problems), and vision and hearing loss. Neurological symptoms may also occur. The exact cause of VKH disease is not well understood, but research suggests it is an autoimmune disease. It is more common in people with darker skin color including Asian, Middle Eastern, Hispanic, and Native American populations. The disease is treated with corticosteroids and other medications.

MalaCards based summary : Vogt-Koyanagi-Harada Disease, also known as uveomeningoencephalitic syndrome, is related to uveitis and alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity. An important gene associated with Vogt-Koyanagi-Harada Disease is PTPN22 (Protein Tyrosine Phosphatase, Non-Receptor Type 22), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Bevacizumab and Angiogenesis Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and retina, and related phenotypes are abnormality of the eyelashes and glaucoma

Disease Ontology : ¹² A hypersensitivity reaction type II disease that is caused by T helper cell mediated autoimmune attack of melanocytes resulting in inflammation of the inside of the eye, whitening of hair, skin pigment loss, and meningitis.

Wikipedia : ⁷⁶ Vogt–Koyanagi–Harada disease (VKH), also known as Vogt–Koyanagi–Harada syndrome, uveomeningitis syndrome... more...

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Related Diseases for Vogt-Koyanagi-Harada Disease

Diseases related to Vogt-Koyanagi-Harada Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 171)

#	Related Disease	Score	Top Affiliating Genes
1	uveitis	31.0	HLA-B IL10 IL17A IL2RA
2	alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity	30.6	IL10 IL17A PTPN22
3	anterior uveitis	30.4	HLA-A HLA-B IL2RA PTPN22
4	graves' disease	29.8	FAS HLA-DQA1 HLA-DRB1 IL2RA PTPN22
5	panuveitis	29.7	HLA-B HLA-DQB1 HLA-DRB1 IL10 IL17A
6	arthritis	28.8	HLA-DQB1 HLA-DRB1 IL10 IL17A NLRP1 PTPN22
7	diabetes mellitus	28.1	FAS HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
8	rheumatoid arthritis	27.2	HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10 IL17A
9	autoimmune disease	26.2	FAS HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10
10	alezzandrini syndrome	11.5
11	choroiditis	11.0
12	limbic encephalitis with lgi1 antibodies	10.9	HLA-DQB1 HLA-DRB1
13	retinitis	10.8
14	metal allergy	10.8	HLA-DQB1 HLA-DRB1
15	hypersomnia	10.8	HLA-DQB1 HLA-DRB1
16	lichen planopilaris	10.8	HLA-DQB1 HLA-DRB1
17	beryllium disease	10.8	HLA-DQB1 HLA-DRB1
18	achalasia, familial esophageal	10.8	HLA-DQA1 HLA-DQB1
19	autoimmune pancreatitis	10.7	HLA-DQB1 HLA-DRB1
20	chronic beryllium disease	10.7	HLA-DQB1 HLA-DRB1
21	rheumatoid factor-negative juvenile idiopathic arthritis	10.7	HLA-DRB1 IL2RA PTPN22
22	osteonecrosis of the jaw	10.7	HLA-DQB1 HLA-DRB1 IL17A
23	autoimmune enteropathy	10.7	IL17A IL2RA
24	hepatitis	10.6
25	phenytoin or carbamazepine toxicity	10.6	HLA-A HLA-B
26	hepatitis c	10.6
27	melanotic neurilemmoma	10.6	PMEL TYR
28	focal epithelial hyperplasia	10.6	HLA-DQA1 HLA-DQB1 HLA-DRB1
29	lichen sclerosus	10.6	HLA-DQB1 HLA-DRB1
30	retinal detachment	10.6
31	diffuse meningeal melanocytosis	10.6	PMEL TYR
32	recurrent respiratory papillomatosis	10.6	HLA-DQA1 HLA-DQB1 HLA-DRB1
33	melanoacanthoma	10.6	PMEL TYR
34	juvenile myasthenia gravis	10.6	HLA-DRB1 IL10
35	whipple disease	10.6	HLA-DQB1 HLA-DRB1
36	melanoma	10.6
37	headache	10.6
38	atrial tachyarrhythmia with short pr interval	10.6	HLA-A HLA-B
39	glaucomatocyclitic crisis	10.5	HLA-A HLA-B
40	halo nevi	10.5	HLA-DRB1 PMEL TYR
41	sympathetic ophthalmia	10.5
42	juvenile rheumatoid arthritis	10.5	HLA-DQA1 HLA-DRB1 IL2RA
43	hyperlucent lung	10.5	IL10 IL2RA
44	palindromic rheumatism	10.5	HLA-A HLA-DRB1 PTPN22
45	leukemia	10.5
46	scleritis	10.5
47	malignant spindle cell melanoma	10.5	PMEL TYR
48	idiopathic inflammatory myopathy	10.4	HLA-B HLA-DQA1 HLA-DRB1
49	postherpetic neuralgia	10.4	HLA-A HLA-B HLA-DRB1
50	hermansky-pudlak syndrome 3	10.4	PMEL TYR TYRP1

Graphical network of the top 20 diseases related to Vogt-Koyanagi-Harada Disease:

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Symptoms & Phenotypes for Vogt-Koyanagi-Harada Disease

Human phenotypes related to Vogt-Koyanagi-Harada Disease:

⁵⁹ ³² (show all 15)

#	Description	HPO Frequency	Orphanet Frequency	HPO Source Accession
1	abnormality of the eyelashes ⁵⁹ ³²	hallmark (90%)	Very frequent (99-80%)	HP:0000499
2	glaucoma ⁵⁹ ³²	frequent (33%)	Frequent (79-30%)	HP:0000501
3	visual impairment ⁵⁹ ³²	frequent (33%)	Frequent (79-30%)	HP:0000505
4	cataract ⁵⁹ ³²	frequent (33%)	Frequent (79-30%)	HP:0000518
5	retinal detachment ⁵⁹ ³²	frequent (33%)	Frequent (79-30%)	HP:0000541
6	sensorineural hearing impairment ⁵⁹ ³²	hallmark (90%)	Very frequent (99-80%)	HP:0000407
7	vitiligo ⁵⁹ ³²	hallmark (90%)	Very frequent (99-80%)	HP:0001045
8	hypopigmented skin patches ⁵⁹ ³²	hallmark (90%)	Very frequent (99-80%)	HP:0001053
9	sparse scalp hair ⁵⁹ ³²	hallmark (90%)	Very frequent (99-80%)	HP:0002209
10	premature graying of hair ⁵⁹ ³²	hallmark (90%)	Very frequent (99-80%)	HP:0002216
11	poliosis ⁵⁹ ³²	hallmark (90%)	Very frequent (99-80%)	HP:0002290
12	short stature ⁵⁹ ³²	frequent (33%)	Frequent (79-30%)	HP:0004322
13	cognitive impairment ⁵⁹ ³²	hallmark (90%)	Very frequent (99-80%)	HP:0100543
14	abnormality of the eyebrow ⁵⁹		Very frequent (99-80%)
15	abnormal eyebrow morphology ³²	hallmark (90%)		HP:0000534

GenomeRNAi Phenotypes related to Vogt-Koyanagi-Harada Disease according to GeneCards Suite gene sharing:

²⁶ (show all 30)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-103	10.27	HLA-B HLA-A
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-110	10.27	HLA-DQA1 HLA-A HLA-B
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-115	10.27	IL2RA
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-118	10.27	HLA-B HLA-A
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-121	10.27	HLA-DQA1 IL2RA
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-130	10.27	IL2RA
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-138	10.27	IL2RA
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-149	10.27	HLA-DQA1
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-156	10.27	HLA-A HLA-B
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-169	10.27	IL2RA
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-174	10.27	IL2RA
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-178	10.27	HLA-B HLA-A
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-185	10.27	IL2RA
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-19	10.27	HLA-B HLA-DQA1 HLA-A IL2RA
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-2	10.27	IL2RA
16	Increased shRNA abundance (Z-score > 2)	GR00366-A-202	10.27	IL2RA
17	Increased shRNA abundance (Z-score > 2)	GR00366-A-25	10.27	IL2RA
18	Increased shRNA abundance (Z-score > 2)	GR00366-A-31	10.27	HLA-B HLA-A
19	Increased shRNA abundance (Z-score > 2)	GR00366-A-45	10.27	HLA-DQA1
20	Increased shRNA abundance (Z-score > 2)	GR00366-A-46	10.27	IL2RA
21	Increased shRNA abundance (Z-score > 2)	GR00366-A-50	10.27	IL2RA
22	Increased shRNA abundance (Z-score > 2)	GR00366-A-52	10.27	IL2RA
23	Increased shRNA abundance (Z-score > 2)	GR00366-A-67	10.27	IL2RA
24	Increased shRNA abundance (Z-score > 2)	GR00366-A-7	10.27	HLA-B HLA-A
25	Increased shRNA abundance (Z-score > 2)	GR00366-A-73	10.27	HLA-DQA1
26	Increased shRNA abundance (Z-score > 2)	GR00366-A-74	10.27	HLA-B HLA-A
27	Increased shRNA abundance (Z-score > 2)	GR00366-A-9	10.27	IL2RA
28	Increased shRNA abundance (Z-score > 2)	GR00366-A-99	10.27	HLA-DQA1
29	Synthetic lethal with MLN4924 (a NAE inhibitor)	GR00250-A-1	9.77	FAS HLA-DQB1 IL10 IL17A IL2RA NLRP1
30	Synthetic lethal with MLN4924 (a NAE inhibitor)	GR00250-A-2	9.77	IL2RA FAS HLA-DQB1 IL10 IL17A NLRP1

MGI Mouse Phenotypes related to Vogt-Koyanagi-Harada Disease:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	10.03	IL17A TYRP1 IL2RA NLRP1 FAS PMEL
2	endocrine/exocrine gland	MP:0005379	9.97	IL10 TYR IL17A IL2RA FAS PTPN22
3	homeostasis/metabolism	MP:0005376	9.9	TLR3 IL10 TYR TYRP1 IL17A IL2RA
4	immune system	MP:0005387	9.7	TYR IL17A IL2RA NLRP1 FAS PTPN22
5	respiratory system	MP:0005388	9.17	IL10 IL17A IL2RA FAS PTPN22 HLA-DQB1

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Drugs & Therapeutics for Vogt-Koyanagi-Harada Disease

Drugs for Vogt-Koyanagi-Harada Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Bevacizumab

Approved, Investigational

Phase 3,Not Applicable

216974-75-3

Angiogenesis Inhibitors

Phase 3,Not Applicable

Angiogenesis Modulating Agents

Phase 3,Not Applicable

Azathioprine

Approved

Not Applicable

446-86-6

2265

Iodine

Approved, Investigational

Not Applicable

7553-56-2

807

Miconazole

Approved, Investigational, Vet_approved

Not Applicable

22916-47-8

4189

Mycophenolate mofetil

Approved, Investigational

Not Applicable

128794-94-5

5281078

Mycophenolic acid

Approved

Not Applicable

24280-93-1

446541

Povidone

Approved

Not Applicable

9003-39-8

Povidone-iodine

Approved

Not Applicable

25655-41-8

Adalimumab

Approved

331731-18-1

16219006

Etanercept

Approved, Investigational

185243-69-0

Infliximab

Approved

170277-31-3

Methotrexate

Approved

1959-05-2, 59-05-2

126941

Methylprednisolone

Approved, Vet_approved

83-43-2

6741

Prednisolone

Approved, Vet_approved

50-24-8

5755

rituximab

Approved

174722-31-7

10201696

Anti-Bacterial Agents

Not Applicable

Antibiotics, Antitubercular

Not Applicable

Antifungal Agents

Not Applicable

Anti-Infective Agents

Not Applicable

Antirheumatic Agents

Not Applicable

cadexomer iodine

Not Applicable

Calcineurin Inhibitors

Not Applicable

Cyclosporins

Not Applicable

Dermatologic Agents

Not Applicable

Immunosuppressive Agents

Not Applicable

Antimetabolites

Antimetabolites, Antineoplastic

Antitubercular Agents

Methylprednisolone acetate

Methylprednisolone Hemisuccinate

Prednisolone acetate

Prednisolone hemisuccinate

Prednisolone phosphate

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Intravitreal Bevacizumab for Inflammatory Neovascular Membranes	Completed	NCT00407121	Phase 3	Bevacizumab
2	Intravitreal Bevacizumab for the Treatment of CNV in VKH Disease - A Prospective Study	Unknown status	NCT02015351	Not Applicable	bevacizumab
3	Causes of Visual Loss in Retinal Disease	Unknown status	NCT01613963		Immunosuppressive Agents
4	Early Immunosuppressive Therapy on the Course of Vogt-Koyanagi-Harada Disease	Recruiting	NCT03399175	Not Applicable	Early high-dose corticosteroid and immunosuppressive therapy

Search NIH Clinical Center for Vogt-Koyanagi-Harada Disease

Cochrane evidence based reviews: uveomeningoencephalitic syndrome

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Genetic Tests for Vogt-Koyanagi-Harada Disease

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Anatomical Context for Vogt-Koyanagi-Harada Disease

MalaCards organs/tissues related to Vogt-Koyanagi-Harada Disease:

⁴¹

Eye, Skin, Retina, T Cells, Myeloid, Liver, Spinal Cord

Sources

Publications for Vogt-Koyanagi-Harada Disease

Articles related to Vogt-Koyanagi-Harada Disease:

(show top 50) (show all 406)

#	Title	Authors	Year
1	Association of Long Noncoding RNAs Polymorphisms With Ankylosing Spondylitis, Vogt-Koyanagi-Harada Disease, and Behcet's Disease. ( 29490353 )	Yue Y....Hou S.	2018
2	Clinical features and visual outcomes of 111 patients with new-onset acute Vogt-Koyanagi-Harada disease treated with pulse intravenous corticosteroids. ( 29666121 )	Nakayama M....Okada A.A.	2018
3	Novel treatment regimen of Vogt-Koyanagi-Harada disease with a reduced dose of corticosteroids combined with immunosuppressive agents. ( 29111815 )	Yang P....Kijlstra A.	2018
4	Retinal Pigment Epithelium Detachment in Acute Vogt-Koyanagi-Harada Disease: An Unusual Finding at Presentation. ( 29513616 )	Khochtali S....Khairallah M.	2018
5	Recovery of macular cone photoreceptors in Vogt-Koyanagi-Harada disease. ( 29264653 )	Nakamura T....Oiwake T.	2018
6	Vogt-Koyanagi-Harada disease: study of 14 cases. ( 29731134 )	Espinosa-Barberi G....Francisco HernA!ndez F.	2018
7	Development and Evaluation of Diagnostic Criteria for Vogt-Koyanagi-Harada Disease. ( 29978190 )	Yang P....Kijlstra A.	2018
8	Changes in Central Macular Thickness and Retinal Nerve Fiber Layer Thickness in Eyes with Vogt-Koyanagi-Harada Disease: A 2-Year Follow-Up Study. ( 29339644 )	Han Y.S....Kim J.Y.	2018
9	Association of human leukocyte antigen (HLA)-DQ and HLA-DQA1/DQB1 alleles with Vogt-Koyanagi-Harada disease: A systematic review and meta-analysis. ( 29443768 )	Liu B....Zhong J.	2018
10	Longitudinal observation of subretinal fibrosis in Vogt-Koyanagi-Harada disease. ( 29334924 )	Zhao C....Zhang M.	2018
11	Vogt-Koyanagi-Harada Disease Presenting as Unilateral Neuroretinits. ( 29467803 )	Pellegrini F....Prosdocimo G.	2018
12	Diagnostic Function of 3D Optical Coherence Tomography Images in Diagnosis of Vogt-Koyanagi-Harada Disease at Acute Uveitis Stage. ( 29396390 )	Zhao G.L....Zhou Z.	2018
13	HLA-DRB1*04:05 in two cases of Vogt-Koyanagi-Harada disease-like uveitis developing from an advanced melanoma patient treated by sequential administration of nivolumab and dabrafenib/trametinib therapy. ( 29488243 )	Fujimura T....Aiba S.	2018
14	Acquired myopia in Vogt-Koyanagi-Harada disease. ( 29397539 )	Takahashi H....Ohno-Matsui K.	2018
15	Vogt-Koyanagi-Harada disease-like uveitis induced by vemurafenib for metastatic cutaneous malignant melanoma. ( 29314171 )	Fusumae T....Ohtsuki M.	2018
16	Vogt-Koyanagi-Harada Disease Associated with Influenza A Virus Infection: A Case Report. ( 29321438 )	Yoshino N....Sugawara H.	2018
17	MR findings of the orbit in patients with Vogt-Koyanagi-Harada disease. ( 29476208 )	Ando T....Matsuo M.	2018
18	Vogt-Koyanagi-Harada disease like presentation in patients with chronic myeloid leukemia. ( 29780937 )	Mistry S....Biswas J.	2018
19	Vogt-Koyanagi-Harada Disease Associated with Hepatitis B Vaccination. ( 29953303 )	Sood A.B....Jain N.	2018
20	Improving the Diagnostic Criteria for Vogt-Koyanagi-Harada Disease. ( 29978179 )	Jabs D.A.	2018
21	Rare association between Vogt-Koyanagi-Harada disease and rheumatoid arthritis: Report of a clinical case from the unit of multidisciplinary uveitis. ( 29519769 )	Paz-Solarte J.A....Calvo-Catala J.	2018
22	MicroRNA-20a-5p suppresses IL-17 production by targeting OSM and CCL1 in patients with Vogt-Koyanagi-Harada disease. ( 28972028 )	Chang R....Yang P.	2018
23	Unusual Case of Vogt-Koyanagi-Harada Disease Associated with SAPHO Syndrome: A Case Report. ( 29681837 )	Hasegawa M....Kamei M.	2018
24	Longitudinal Study of Visual Function in Vogt-Koyanagi-Harada Disease Using Full-Field Electroretinography. ( 29702075 )	Yuan W....Yang P.	2018
25	Polarization-Sensitive Optical Coherence Tomographic Documentation of Choroidal Melanin Loss in Chronic Vogt-Koyanagi-Harada Disease. ( 28863408 )	Miura M....Goto H.	2017
26	Promoter Hypermethylation of GATA3, IL-4, and TGF-I^ Confers Susceptibility to Vogt-Koyanagi-Harada Disease in Han Chinese. ( 28278322 )	Zhu Y....Yang P.	2017
27	Vogt-Koyanagi-Harada disease in a patient of chronic myeloid leukemia. ( 28574001 )	Chawla R....Vohra R.	2017
28	Increased Complement 3a Receptor is Associated with Behcet's disease and Vogt-Koyanagi-Harada disease. ( 29138505 )	Wang C....Yang P.	2017
29	Bilateral Iris Depigmentation and Ocular Hypotony as End-Stage Manifestations of Untreated Vogt-Koyanagi-Harada Disease. ( 28548582 )	Cuevas M....CA^rdoba A.	2017
30	Expression and role of interleukin-9 in Vogt-Koyanagi-Harada disease. ( 28761327 )	Peng Z....Wang Q.	2017
31	Evaluation of Vestibular Functions in Patients with Vogt-Koyanagi-Harada Disease. ( 29080887 )	Fujiwara K....Homma A.	2017
32	Vogt-Koyanagi-Harada disease-like posterior uveitis in the course of nivolumab (anti-PD-1 antibody), interposed by vemurafenib (BRAF inhibitor), for metastatic cutaneous malignant melanoma. ( 28469878 )	Matsuo T....Yamasaki O.	2017
33	Clinical spectrum and management options in Vogt-Koyanagi-Harada disease. ( 28848322 )	Lodhi S.A....Peram V.	2017
34	Optical Coherence Tomography Angiography: Employing a Novel Technique for Investigation in Vogt-Koyanagi-Harada Disease. ( 28868031 )	Giannakouras P....Diagourtas A.	2017
35	Unilateral Ocular Manifestations of Vogt-Koyanagi-Harada Disease. ( 29020488 )	Tsui E....Barbazetto I.	2017
36	Photoreceptor Cell Injury Starts in the Initial Stage of Vogt-Koyanagi-Harada Disease. ( 28323511 )	Zhu R....Yang L.	2017
37	Corticotherapy vs. Corticotherapy Plus Immunosuppressive Therapy in Acute Vogt-Koyanagi-Harada Disease. ( 29258782 )	Concha-Del RA-o L.E....Arellanes-GarcA-a L.	2017
38	The spectrum of Vogt-Koyanagi-Harada disease in Iran. ( 28260142 )	Hedayatfar A....Soheilian M.	2017
39	Optical coherence tomography angiography in incomplete acute Vogt-Koyanagi-Harada disease. ( 28503445 )	Cennamo G....Cennamo G.	2017
40	The effect on choroidal changes of the route of systemic corticosteroids in acute Vogt-Koyanagi-Harada disease. ( 28382438 )	Park U.C....Yu H.G.	2017
41	Distinguishing features of acute Vogt-Koyanagi-Harada disease and acute central serous chorioretinopathy on optical coherence tomography angiography and en face optical coherence tomography imaging. ( 28091938 )	Aggarwal K....Gupta V.	2017
42	Wide-field fluorescein and indocyanine green angiography findings in the eyes with Vogt-Koyanagi-Harada disease. ( 28695542 )	Kurobe R....Ogura Y.	2017
43	Management of a rare presentation of Vogt-Koyanagi-Harada disease in human immunodeficiency virus/acquired immunodeficiency disease syndrome patient. ( 28574002 )	Priya D....Biswas J.	2017
44	Differences in photoreceptor recovery among patients and between different parts of the posterior pole in Vogt-Koyanagi-Harada disease. ( 29148525 )	Zhou M....Xu G.Z.	2017
45	Choroidal and Retinal Anatomical Responses Following Systemic Corticosteroid Therapy in Vogt-Koyanagi-Harada Disease Using Swept-Source Optical Coherence Tomography. ( 28700251 )	Jaisankar D....Biswas J.	2017
46	Hypermethylation of Interferon Regulatory Factor 8 (IRF8) Confers Risk to Vogt-Koyanagi-Harada Disease. ( 28432342 )	Qiu Y....Yang P.	2017
47	A case of Vogt Koyanagi Harada disease in a 16 year old girl. ( 29171577 )	Khan F....Iqbal M.	2017
48	Evaluation of the Glucocorticoid Receptor as a Biomarker of Treatment Response in Vogt-Koyanagi-Harada Disease. ( 28535268 )	Urzua C.A....Goecke A.	2017
49	Induction of Vogt-Koyanagi-Harada Disease by Interferon-Alpha and Ribavirin Treatment in Patients with Hepatitis C: A Case Report and Review of the Literature. ( 29023176 )	Duan J....Ma J.	2017
50	The Choroidal Vascularity Index Decreases and Choroidal Thickness Increases in Vogt-Koyanagi-Harada Disease Patients During a Recurrent Anterior Uveitis Attack. ( 28914578 )	Liu S....Yang P.	2017

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Genes for Vogt-Koyanagi-Harada Disease

Genes related to Vogt-Koyanagi-Harada Disease (2 elite genes):

(show all 17)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	PTPN22	Protein Tyrosine Phosphatase, Non-Receptor Type 22	Protein Coding	46.48	Susceptibility factor ⁵⁹ DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	HLA-DRB1	Major Histocompatibility Complex, Class II, DR Beta 1	Protein Coding	30.28	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	7906684 15603876
3	TYR	Tyrosinase	Protein Coding	30.28	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	9510558
4	FAS	Fas Cell Surface Death Receptor	Protein Coding	29.24	Susceptibility factor ⁵⁹ Novoseek inferred ⁵⁵	11815887 15454035 9646088 (more) 8654110 9400790
5	ARMC9	Armadillo Repeat Containing 9	Protein Coding	23.72	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	IL2RA	Interleukin 2 Receptor Subunit Alpha	Protein Coding	22.82	Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	10342043 1635294
7	IL17A	Interleukin 17A	Protein Coding	22.61	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
8	HLA-DQA1	Major Histocompatibility Complex, Class II, DQ Alpha 1	Protein Coding	22.55	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	HLA-A	Major Histocompatibility Complex, Class I, A	Protein Coding	22.51	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
10	HLA-DQB1	Major Histocompatibility Complex, Class II, DQ Beta 1	Protein Coding	22.39	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
11	HLA-B	Major Histocompatibility Complex, Class I, B	Protein Coding	22.37	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
12	PMEL	Premelanosome Protein	Protein Coding	21.86	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
13	TYRP1	Tyrosinase Related Protein 1	Protein Coding	21.67	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
14	TGFBR3	Transforming Growth Factor Beta Receptor 3	Protein Coding	21.45	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
15	IL10	Interleukin 10	Protein Coding	21.11	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
16	NLRP1	NLR Family Pyrin Domain Containing 1	Protein Coding	21.11	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
17	TLR3	Toll Like Receptor 3	Protein Coding	21	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)

Sources

Variations for Vogt-Koyanagi-Harada Disease

Sources

Expression for Vogt-Koyanagi-Harada Disease

Search GEO for disease gene expression data for Vogt-Koyanagi-Harada Disease.

Sources

Pathways for Vogt-Koyanagi-Harada Disease

Pathways related to Vogt-Koyanagi-Harada Disease according to GeneCards Suite gene sharing:

(show all 30)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.93	HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10
2	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	13.24	HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10
3	PAK Pathway ⁶⁴ Show member pathways Antioxidant Action of Vitamin-C ⁶⁴ Epithelial Adherens Junctions ⁶⁴	13.19	FAS IL10 IL17A IL2RA PTPN22 TGFBR3
4	PI3K-Akt signaling pathway ³⁷ Show member pathways Human papillomavirus infection ³⁷	12.87	FAS HLA-A HLA-B IL2RA TLR3
5	Actin Nucleation by ARP-WASP Complex ⁶⁴ Show member pathways Actin Nucleation and Branching ⁶⁴ CDC42 Pathway ⁶⁴ RhoA Pathway ⁶⁴	12.85	HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
6	Regulation of IFNA signaling ⁶⁶ Show member pathways Cytokine Network ⁶⁴ Immune response IFN alpha/beta signaling pathway ²² Interferon alpha/beta signaling ⁶⁶ Interleukin-19, 20, 22, 24 ⁶⁶ Jak/STAT Signaling Pathway ⁶⁵ Jak-STAT signaling pathway ³⁷	12.55	HLA-A HLA-B IL10 IL17A IL2RA
7	Kaposi's sarcoma-associated herpesvirus infection ³⁷ Show member pathways Hepatitis B ³⁷	12.46	FAS HLA-A HLA-B TLR3
8	Interferon gamma signaling ⁶⁶ Show member pathways Interferon Signaling ⁶⁶ Regulation of IFNG signaling ⁶⁶	12.46	HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
9	ICos-ICosL Pathway in T-Helper Cell ⁶⁴ Show member pathways Calcium Mediated T-Cell Apoptosis ⁶⁴ CD28 Signaling in T-Helper Cell ⁶⁴	12.29	HLA-DQA1 HLA-DQB1 HLA-DRB1 IL2RA
10	Th17 cell differentiation ³⁷ Show member pathways Inflammatory bowel disease (IBD) ³⁷ Th1 and Th2 cell differentiation ³⁷	12.27	HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10 IL17A IL2RA
11	TCR signaling (REACTOME) ⁶⁶ Show member pathways TCR signaling ⁶⁶	12.25	HLA-DQA1 HLA-DQB1 HLA-DRB1 PTPN22
12	Influenza A ³⁷ Show member pathways Herpes simplex infection ³⁷ Measles ³⁷	12.25	FAS HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
13	HTLV-I infection ³⁷	12.21	HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1 IL2RA
14	NF-kappaB Signaling ⁴	12.21	FAS IL10 IL17A IL2RA NLRP1 PTPN22
15	Toxoplasmosis ³⁷ Show member pathways Leishmaniasis ³⁷	12.16	HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10
16	Tuberculosis ³⁷	12.14	HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10
17	Immune response Antigen presentation by MHC class II ²² Show member pathways G-protein signaling N-RAS regulation pathway ²² IL-22 Pathway ⁶⁴ Immune response IL-22 signaling pathway ²²	12.08	HLA-DQA1 HLA-DQB1 HLA-DRB1 IL2RA
18	Epstein-Barr virus infection ³⁷	12.04	HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10
19	Allograft rejection ¹ ³⁷ Show member pathways Antigen processing and presentation ³⁷ Asthma ³⁷ Autoimmune thyroid disease ³⁷ CTL Mediated Apoptosis ⁶⁴ Graft-versus-host disease ³⁷ Intestinal immune network for IgA production ³⁷ THC Differentiation Pathway ⁶⁴ Type I diabetes mellitus ³⁷ Viral myocarditis ³⁷	12.02	FAS HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
20	Phagosome ³⁷	12.01	HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
21	Cell adhesion molecules (CAMs) ³⁷	11.96	HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
22	Translocation of ZAP-70 to Immunological synapse ⁶⁶ Show member pathways Generation of second messenger molecules ⁶⁶ PD-1 signaling ⁶⁶ Phosphorylation of CD3 and TCR zeta chains ⁶⁶	11.87	HLA-DQA1 HLA-DQB1 HLA-DRB1 PTPN22
23	IL12-mediated signaling events ¹ Show member pathways Immune response IL-12-induced IFN-gamma production ²²	11.86	HLA-A HLA-DRB1 IL2RA
24	MHC class II antigen presentation ⁶⁶	11.82	HLA-DQA1 HLA-DQB1 HLA-DRB1
25	Hematopoietic cell lineage ³⁷	11.8	HLA-DQA1 HLA-DQB1 HLA-DRB1 IL2RA
26	Rheumatoid arthritis ³⁷	11.75	HLA-DQA1 HLA-DQB1 HLA-DRB1 IL17A
27	Innate Lymphoid Cell Differentiation Pathways ⁶⁵	11.7	IL10 IL17A IL2RA
28	CTLA4 Signaling ⁶⁴	11.63	HLA-DQA1 HLA-DQB1 HLA-DRB1 PTPN22
29	Staphylococcus aureus infection ³⁷	11.51	HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10
30	Melanin biosynthesis ⁶⁶	10.27	TYR TYRP1

Sources

GO Terms for Vogt-Koyanagi-Harada Disease

Cellular components related to Vogt-Koyanagi-Harada Disease according to GeneCards Suite gene sharing:

(show all 17)

#	Name	GO ID	Score	Top Affiliating Genes
1	Golgi membrane	GO:0000139	9.88	HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1 TLR3
2	lysosomal membrane	GO:0005765	9.87	HLA-DQA1 HLA-DQB1 HLA-DRB1 TLR3
3	external side of plasma membrane	GO:0009897	9.85	HLA-DRB1 IL17A IL2RA TGFBR3
4	cell surface	GO:0009986	9.8	FAS HLA-A HLA-B HLA-DRB1 IL2RA TGFBR3
5	endosome membrane	GO:0010008	9.77	HLA-DQA1 HLA-DQB1 HLA-DRB1 TLR3 TYRP1
6	melanosome	GO:0042470	9.73	PMEL TYR TYRP1
7	trans-Golgi network membrane	GO:0032588	9.67	HLA-DQA1 HLA-DQB1 HLA-DRB1
8	endocytic vesicle membrane	GO:0030666	9.63	HLA-DQA1 HLA-DQB1 HLA-DRB1
9	transport vesicle membrane	GO:0030658	9.61	HLA-DQA1 HLA-DQB1 HLA-DRB1
10	melanosome membrane	GO:0033162	9.52	TYR TYRP1
11	MHC class II protein complex	GO:0042613	9.5	HLA-DQA1 HLA-DQB1 HLA-DRB1
12	MHC class I protein complex	GO:0042612	9.48	HLA-A HLA-B
13	clathrin-coated endocytic vesicle membrane	GO:0030669	9.46	HLA-DQA1 HLA-DQB1 HLA-DRB1 TYRP1
14	ER to Golgi transport vesicle membrane	GO:0012507	9.35	HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
15	integral component of lumenal side of endoplasmic reticulum membrane	GO:0071556	9.02	HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
16	integral component of membrane	GO:0016021	10.31	FAS HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
17	integral component of plasma membrane	GO:0005887	10.05	FAS HLA-A HLA-B HLA-DQA1 PMEL TGFBR3

Biological processes related to Vogt-Koyanagi-Harada Disease according to GeneCards Suite gene sharing:

(show all 18)

#	Name	GO ID	Score	Top Affiliating Genes
1	inflammatory response	GO:0006954	9.88	FAS IL10 IL17A IL2RA NLRP1 TLR3
2	immune system process	GO:0002376	9.86	HLA-A HLA-B HLA-DQA1 HLA-DRB1 IL2RA NLRP1
3	T cell receptor signaling pathway	GO:0050852	9.78	HLA-DQA1 HLA-DQB1 HLA-DRB1 PTPN22
4	antigen processing and presentation of exogenous peptide antigen via MHC class II	GO:0019886	9.73	HLA-DQA1 HLA-DQB1 HLA-DRB1
5	T cell costimulation	GO:0031295	9.72	HLA-DQA1 HLA-DQB1 HLA-DRB1
6	negative regulation of T cell proliferation	GO:0042130	9.63	HLA-DRB1 IL10 IL2RA
7	melanosome organization	GO:0032438	9.58	PMEL TYRP1
8	inflammatory response to antigenic stimulus	GO:0002437	9.57	HLA-DRB1 IL2RA
9	interferon-gamma-mediated signaling pathway	GO:0060333	9.55	HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
10	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent	GO:0002480	9.54	HLA-A HLA-B
11	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	GO:0002504	9.54	HLA-DQA1 HLA-DQB1 HLA-DRB1
12	necroptotic signaling pathway	GO:0097527	9.52	FAS TLR3
13	protection from natural killer cell mediated cytotoxicity	GO:0042270	9.51	HLA-A HLA-B
14	melanin biosynthetic process	GO:0042438	9.5	PMEL TYR TYRP1
15	humoral immune response mediated by circulating immunoglobulin	GO:0002455	9.49	HLA-DQB1 HLA-DRB1
16	immunoglobulin production involved in immunoglobulin mediated immune response	GO:0002381	9.43	HLA-DQB1 HLA-DRB1
17	antigen processing and presentation	GO:0019882	9.35	HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
18	immune response	GO:0006955	9.32	FAS HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1

Molecular functions related to Vogt-Koyanagi-Harada Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	MHC class II receptor activity	GO:0032395	9.13	HLA-DQA1 HLA-DQB1 HLA-DRB1
2	peptide antigen binding	GO:0042605	9.02	HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
3	protein binding	GO:0005515	10.09	ARMC9 FAS HLA-A HLA-B HLA-DQA1 HLA-DQB1

Sources

Sources for Vogt-Koyanagi-Harada Disease

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia