MCID: VGT001
MIFTS: 59

Vogt-Koyanagi-Harada Disease

Categories: Eye diseases, Immune diseases, Neuronal diseases, Rare diseases, Skin diseases

Aliases & Classifications for Vogt-Koyanagi-Harada Disease

MalaCards integrated aliases for Vogt-Koyanagi-Harada Disease:

Name: Vogt-Koyanagi-Harada Disease 12 53 59 55 15
Uveomeningoencephalitic Syndrome 12 44 73
Vogt-Koyanagi-Harada Syndrome 53 37
Uveomenigitic Syndrome 53 59
Vogt-Koyanagi Syndrome 12
Harada's Disease 12
Vkh Syndrome 53
Vkh Disease 53

Characteristics:

Orphanet epidemiological data:

59
vogt-koyanagi-harada disease
Inheritance: Multigenic/multifactorial; Age of onset: All ages; Age of death: normal life expectancy;

Classifications:



External Ids:

Disease Ontology 12 DOID:12297
ICD10 33 H20.82 H30.81
ICD9CM 35 363.22 364.24
MeSH 44 D014607
NCIt 50 C85218
SNOMED-CT 68 44923005 47230004
Orphanet 59 ORPHA3437
ICD10 via Orphanet 34 H20.8 H30.8
UMLS via Orphanet 74 C0042170
KEGG 37 H01504
UMLS 73 C0042170

Summaries for Vogt-Koyanagi-Harada Disease

NIH Rare Diseases : 53 Vogt-Koyanagi-Harada disease (VKH disease) is a disease that affects several parts of the body, including the eyes, ears, nervous system, and skin. The signs and symptoms of VKH disease are caused by chronic inflammation of melanocytes. Melanocytes are specialized cells that produce a pigment called melanin. Melanin is the substance that gives skin, hair, and eyes their color. Melanin is also found in other parts of the body, such as the retina of the eyes, where it plays a role in normal vision, and in the inner ear, where it is thought to be involved in hearing. People with VKH disease usually develop vision and hearing problems first, followed by signs of skin problems. The most common symptoms include headaches, inflammation of all layers of the colored part of the eye (panuveitis), white patches of skin (vitiligo), hair loss (alopecia), dizziness and nausea (inner ear related problems), and vision and hearing loss. Neurological symptoms may also occur. The exact cause of VKH disease is not well understood, but research suggests it is an autoimmune disease. It is more common in people with darker skin color including Asian, Middle Eastern, Hispanic, and Native American populations. The disease is treated with corticosteroids and other medications.

MalaCards based summary : Vogt-Koyanagi-Harada Disease, also known as uveomeningoencephalitic syndrome, is related to uveitis and pars planitis. An important gene associated with Vogt-Koyanagi-Harada Disease is PTPN22 (Protein Tyrosine Phosphatase, Non-Receptor Type 22), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Bevacizumab and Angiogenesis Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and retina, and related phenotypes are cataract and sensorineural hearing impairment

Disease Ontology : 12 An autoimmune hypersensitivity disease that is caused by T helper cell mediated autoimmune attack of melanocytes resulting in inflammation of the inside of the eye, whitening of hair, skin pigment loss, and meningitis.

Related Diseases for Vogt-Koyanagi-Harada Disease

Diseases related to Vogt-Koyanagi-Harada Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 205)
# Related Disease Score Top Affiliating Genes
1 uveitis 31.3 HLA-B IL10 IL17A IL2RA
2 pars planitis 30.9 HLA-A HLA-B HLA-DRB1
3 halo nevi 30.7 HLA-DRB1 PMEL TYR
4 anterior uveitis 30.5 HLA-A HLA-B IL2RA PTPN22
5 alopecia areata 30.4 HLA-A HLA-DQA1 IL17A IL2RA PTPN22
6 herpes zoster 30.4 HLA-A HLA-B IL10
7 graves' disease 30.3 FAS HLA-DQA1 HLA-DRB1 IL2RA PTPN22
8 vitiligo-associated multiple autoimmune disease susceptibility 1 30.2 NLRP1 PMEL PTPN22 TYR TYRP1
9 panuveitis 30.1 HLA-A HLA-B HLA-DQB1 HLA-DRB1 IL10 IL17A
10 arthritis 30.0 HLA-DQB1 HLA-DRB1 IL10 IL17A NLRP1 PTPN22
11 diabetes mellitus 29.8 FAS HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
12 rheumatoid arthritis 29.5 HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10 IL17A
13 autoimmune disease 29.2 FAS HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10
14 alezzandrini syndrome 11.6
15 hepatitis 10.8
16 retinal detachment 10.8
17 hepatitis c 10.8
18 melanoma 10.7
19 headache 10.7
20 sympathetic ophthalmia 10.7
21 leukemia 10.6
22 scleritis 10.6
23 central serous chorioretinopathy 10.6
24 aseptic meningitis 10.5
25 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.5
26 alopecia 10.5
27 lymphoma 10.5
28 posterior scleritis 10.5
29 neuropathy 10.5
30 acute posterior multifocal placoid pigment epitheliopathy 10.5
31 cataract 10.5
32 lymphocytic leukemia 10.5
33 meningoencephalitis 10.5
34 choroiditis 10.5
35 optic neuritis 10.5
36 posterior uveitis 10.5
37 acute closed-angle glaucoma 10.5
38 neuritis 10.5
39 optic nerve disease 10.5
40 myeloid leukemia 10.5
41 psoriasis 10.5
42 viral infectious disease 10.5
43 meningitis 10.5
44 degos 'en cocarde' erythrokeratoderma 10.5
45 homocysteinemia 10.3
46 tubulointerstitial nephritis with uveitis 10.3
47 brain meningioma 10.3
48 common variable immunodeficiency 10.3
49 intraocular lymphoma 10.3
50 keratopathy 10.3

Graphical network of the top 20 diseases related to Vogt-Koyanagi-Harada Disease:



Diseases related to Vogt-Koyanagi-Harada Disease

Symptoms & Phenotypes for Vogt-Koyanagi-Harada Disease

Human phenotypes related to Vogt-Koyanagi-Harada Disease:

59 32 (show all 16)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 cataract 59 32 frequent (33%) Frequent (79-30%) HP:0000518
2 sensorineural hearing impairment 59 32 hallmark (90%) Very frequent (99-80%) HP:0000407
3 visual impairment 59 32 frequent (33%) Frequent (79-30%) HP:0000505
4 short stature 59 32 frequent (33%) Frequent (79-30%) HP:0004322
5 cognitive impairment 59 32 hallmark (90%) Very frequent (99-80%) HP:0100543
6 vitiligo 59 32 hallmark (90%) Very frequent (99-80%) HP:0001045
7 hypopigmented skin patches 59 32 hallmark (90%) Very frequent (99-80%) HP:0001053
8 premature graying of hair 59 32 hallmark (90%) Very frequent (99-80%) HP:0002216
9 glaucoma 59 32 frequent (33%) Frequent (79-30%) HP:0000501
10 retinal detachment 59 32 frequent (33%) Frequent (79-30%) HP:0000541
11 sparse scalp hair 59 32 hallmark (90%) Very frequent (99-80%) HP:0002209
12 poliosis 59 32 hallmark (90%) Very frequent (99-80%) HP:0002290
13 abnormality of the eyelashes 59 Very frequent (99-80%)
14 abnormality of the eyebrow 59 Very frequent (99-80%)
15 abnormal eyelash morphology 32 hallmark (90%) HP:0000499
16 abnormal eyebrow morphology 32 hallmark (90%) HP:0000534

GenomeRNAi Phenotypes related to Vogt-Koyanagi-Harada Disease according to GeneCards Suite gene sharing:

26 (show all 30)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 10.27 HLA-A HLA-B
2 Increased shRNA abundance (Z-score > 2) GR00366-A-110 10.27 HLA-A HLA-B HLA-DQA1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-115 10.27 IL2RA
4 Increased shRNA abundance (Z-score > 2) GR00366-A-118 10.27 HLA-A HLA-B
5 Increased shRNA abundance (Z-score > 2) GR00366-A-121 10.27 HLA-DQA1 IL2RA
6 Increased shRNA abundance (Z-score > 2) GR00366-A-130 10.27 IL2RA
7 Increased shRNA abundance (Z-score > 2) GR00366-A-138 10.27 IL2RA
8 Increased shRNA abundance (Z-score > 2) GR00366-A-149 10.27 HLA-DQA1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-156 10.27 HLA-A HLA-B
10 Increased shRNA abundance (Z-score > 2) GR00366-A-169 10.27 IL2RA
11 Increased shRNA abundance (Z-score > 2) GR00366-A-174 10.27 IL2RA
12 Increased shRNA abundance (Z-score > 2) GR00366-A-178 10.27 HLA-A HLA-B
13 Increased shRNA abundance (Z-score > 2) GR00366-A-185 10.27 IL2RA
14 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.27 HLA-A HLA-B HLA-DQA1 IL2RA
15 Increased shRNA abundance (Z-score > 2) GR00366-A-2 10.27 IL2RA
16 Increased shRNA abundance (Z-score > 2) GR00366-A-202 10.27 IL2RA
17 Increased shRNA abundance (Z-score > 2) GR00366-A-25 10.27 IL2RA
18 Increased shRNA abundance (Z-score > 2) GR00366-A-31 10.27 HLA-A HLA-B
19 Increased shRNA abundance (Z-score > 2) GR00366-A-45 10.27 HLA-DQA1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-46 10.27 IL2RA
21 Increased shRNA abundance (Z-score > 2) GR00366-A-50 10.27 IL2RA
22 Increased shRNA abundance (Z-score > 2) GR00366-A-52 10.27 IL2RA
23 Increased shRNA abundance (Z-score > 2) GR00366-A-67 10.27 IL2RA
24 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.27 HLA-A HLA-B
25 Increased shRNA abundance (Z-score > 2) GR00366-A-73 10.27 HLA-DQA1
26 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.27 HLA-A HLA-B
27 Increased shRNA abundance (Z-score > 2) GR00366-A-9 10.27 IL2RA
28 Increased shRNA abundance (Z-score > 2) GR00366-A-99 10.27 HLA-DQA1
29 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.77 FAS HLA-DQB1 IL10 IL17A IL2RA NLRP1
30 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.77 FAS HLA-DQB1 IL10 IL17A IL2RA NLRP1

MGI Mouse Phenotypes related to Vogt-Koyanagi-Harada Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.03 FAS HLA-DQA1 HLA-DQB1 IL10 IL17A IL2RA
2 endocrine/exocrine gland MP:0005379 9.97 FAS HLA-DQA1 HLA-DQB1 IL10 IL17A IL2RA
3 homeostasis/metabolism MP:0005376 9.9 FAS HLA-DQB1 IL10 IL17A IL2RA NLRP1
4 immune system MP:0005387 9.7 FAS HLA-DQA1 HLA-DQB1 IL10 IL17A IL2RA
5 respiratory system MP:0005388 9.17 FAS HLA-DQB1 IL10 IL17A IL2RA PTPN22

Drugs & Therapeutics for Vogt-Koyanagi-Harada Disease

Drugs for Vogt-Koyanagi-Harada Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 3,Not Applicable 216974-75-3
2 Angiogenesis Inhibitors Phase 3,Not Applicable
3 Angiogenesis Modulating Agents Phase 3,Not Applicable
4
Povidone-iodine Approved Not Applicable 25655-41-8
5
Povidone Approved Not Applicable 9003-39-8
6
Iodine Approved, Investigational Not Applicable 7553-56-2 807
7
Azathioprine Approved Not Applicable 446-86-6 2265
8
Mycophenolic acid Approved Not Applicable 24280-93-1 446541
9
Miconazole Approved, Investigational, Vet_approved Not Applicable 22916-47-8 4189
10
Infliximab Approved 170277-31-3
11
Methotrexate Approved 59-05-2, 1959-05-2 126941
12
Prednisolone Approved, Vet_approved 50-24-8 5755
13
rituximab Approved 174722-31-7 10201696
14
Etanercept Approved, Investigational 185243-69-0
15
Methylprednisolone Approved, Vet_approved 83-43-2 6741
16
Adalimumab Approved 331731-18-1 16219006
17
Methylprednisolone hemisuccinate Approved 2921-57-5
18
Prednisolone phosphate Approved, Vet_approved 302-25-0
19
Prednisolone hemisuccinate Experimental 2920-86-7
20 Immunosuppressive Agents Not Applicable
21 Calcineurin Inhibitors Not Applicable
22 Anti-Bacterial Agents Not Applicable
23 Dermatologic Agents Not Applicable
24 Immunologic Factors Not Applicable
25 Cyclosporins Not Applicable
26 Anti-Infective Agents Not Applicable
27 Antifungal Agents Not Applicable
28 Antibiotics, Antitubercular Not Applicable
29 Antirheumatic Agents Not Applicable
30 cadexomer iodine Not Applicable
31 Prednisolone acetate
32 Methylprednisolone acetate
33 Antitubercular Agents
34 Antimetabolites
35 Antimetabolites, Antineoplastic

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Intravitreal Bevacizumab for Inflammatory Neovascular Membranes Completed NCT00407121 Phase 3 Bevacizumab
2 Intravitreal Bevacizumab for the Treatment of CNV in VKH Disease - A Prospective Study Unknown status NCT02015351 Not Applicable bevacizumab
3 Causes of Visual Loss in Retinal Disease Unknown status NCT01613963 Immunosuppressive Agents
4 Multimodal Analysis and Electroretinogram in VKH From Acute Onset - Part I Completed NCT03811366 Not Applicable Meticorten
5 Early Immunosuppressive Therapy on the Course of Vogt-Koyanagi-Harada Disease Recruiting NCT03399175 Not Applicable Early high-dose corticosteroid and immunosuppressive therapy

Search NIH Clinical Center for Vogt-Koyanagi-Harada Disease

Cochrane evidence based reviews: uveomeningoencephalitic syndrome

Genetic Tests for Vogt-Koyanagi-Harada Disease

Anatomical Context for Vogt-Koyanagi-Harada Disease

MalaCards organs/tissues related to Vogt-Koyanagi-Harada Disease:

41
Eye, Skin, Retina, T Cells, Myeloid, Ovary, Lung

Publications for Vogt-Koyanagi-Harada Disease

Articles related to Vogt-Koyanagi-Harada Disease:

(show top 50) (show all 444)
# Title Authors Year
1
Association of Long Noncoding RNAs Polymorphisms With Ankylosing Spondylitis, Vogt-Koyanagi-Harada Disease, and Behcet's Disease. ( 29490353 )
2018
2
Clinical features and visual outcomes of 111 patients with new-onset acute Vogt-Koyanagi-Harada disease treated with pulse intravenous corticosteroids. ( 29666121 )
2018
3
Novel treatment regimen of Vogt-Koyanagi-Harada disease with a reduced dose of corticosteroids combined with immunosuppressive agents. ( 29111815 )
2018
4
Retinal Pigment Epithelium Detachment in Acute Vogt-Koyanagi-Harada Disease: An Unusual Finding at Presentation. ( 29513616 )
2018
5
Recovery of macular cone photoreceptors in Vogt-Koyanagi-Harada disease. ( 29264653 )
2018
6
Vogt-Koyanagi-Harada disease: study of 14 cases. ( 29731134 )
2018
7
Development and Evaluation of Diagnostic Criteria for Vogt-Koyanagi-Harada Disease. ( 29978190 )
2018
8
Changes in Central Macular Thickness and Retinal Nerve Fiber Layer Thickness in Eyes with Vogt-Koyanagi-Harada Disease: A 2-Year Follow-Up Study. ( 29339644 )
2018
9
Association of human leukocyte antigen (HLA)-DQ and HLA-DQA1/DQB1 alleles with Vogt-Koyanagi-Harada disease: A systematic review and meta-analysis. ( 29443768 )
2018
10
Longitudinal observation of subretinal fibrosis in Vogt-Koyanagi-Harada disease. ( 29334924 )
2018
11
Vogt-Koyanagi-Harada Disease Presenting as Unilateral Neuroretinits. ( 29467803 )
2018
12
Diagnostic Function of 3D Optical Coherence Tomography Images in Diagnosis of Vogt-Koyanagi-Harada Disease at Acute Uveitis Stage. ( 29396390 )
2018
13
HLA-DRB1*04:05 in two cases of Vogt-Koyanagi-Harada disease-like uveitis developing from an advanced melanoma patient treated by sequential administration of nivolumab and dabrafenib/trametinib therapy. ( 29488243 )
2018
14
Acquired myopia in Vogt-Koyanagi-Harada disease. ( 29397539 )
2018
15
Vogt-Koyanagi-Harada disease-like uveitis induced by vemurafenib for metastatic cutaneous malignant melanoma. ( 29314171 )
2018
16
Vogt-Koyanagi-Harada Disease Associated with Influenza A Virus Infection: A Case Report. ( 29321438 )
2018
17
MR findings of the orbit in patients with Vogt-Koyanagi-Harada disease. ( 29476208 )
2018
18
Vogt-Koyanagi-Harada disease like presentation in patients with chronic myeloid leukemia. ( 29780937 )
2018
19
Vogt-Koyanagi-Harada Disease Associated with Hepatitis B Vaccination. ( 29953303 )
2018
20
Improving the Diagnostic Criteria for Vogt-Koyanagi-Harada Disease. ( 29978179 )
2018
21
Rare association between Vogt-Koyanagi-Harada disease and rheumatoid arthritis: Report of a clinical case from the unit of multidisciplinary uveitis. ( 29519769 )
2018
22
MicroRNA-20a-5p suppresses IL-17 production by targeting OSM and CCL1 in patients with Vogt-Koyanagi-Harada disease. ( 28972028 )
2018
23
TUBERCULOUS CHOROIDITIS IN PATIENT WITH VOGT-KOYANAGI-HARADA DISEASE. ( 30074567 )
2018
24
Probable Vogt-Koyanagi-Harada disease with granulomatous tattoo-related dermatitis. ( 30340735 )
2018
25
A case of Vogt-Koyanagi-Harada disease as a sequela of drug reaction with eosinophilia and systemic symptoms. ( 30306111 )
2018
26
Incomplete Vogt-Koyanagi-Harada disease following treatment with encorafenib and binimetinib for metastatic melanoma. ( 30169430 )
2018
27
Unusual Case of Vogt-Koyanagi-Harada Disease Associated with SAPHO Syndrome: A Case Report. ( 29681837 )
2018
28
A challenging case of tuberculosis-associated uveitis after corticosteroid treatment for Vogt-Koyanagi-Harada disease. ( 30140653 )
2018
29
Contribution of dual fluorescein and indocyanine green angiography to the appraisal of posterior involvement in birdshot retinochoroiditis and Vogt-Koyanagi-Harada disease. ( 28299496 )
2018
30
Multispectral image analysis in Vogt-Koyanagi-Harada disease. ( 29220112 )
2018
31
Longitudinal Study of Visual Function in Vogt-Koyanagi-Harada Disease Using Full-Field Electroretinography. ( 29702075 )
2018
32
Long term treatment with infliximab in pediatric Vogt-Koyanagi-Harada disease. ( 29998211 )
2018
33
Ultra-wide-field angiography findings in acute Vogt-Koyanagi-Harada disease. ( 30100554 )
2018
34
Optical Coherence Tomography Angiography for Evaluation of Sattler's Layer in Vogt-Koyanagi-Harada Disease. ( 30114311 )
2018
35
Disabled-2 (DAB2) Overexpression Inhibits Monocyte-Derived Dendritic Cells' Function in Vogt-Koyanagi-Harada Disease. ( 30267088 )
2018
36
Association Study of ARMC9 Gene Variants with Vogt-Koyanagi-Harada Disease in Japanese Patients. ( 30395750 )
2018
37
Polarization-Sensitive Optical Coherence Tomographic Documentation of Choroidal Melanin Loss in Chronic Vogt-Koyanagi-Harada Disease. ( 28863408 )
2017
38
Promoter Hypermethylation of GATA3, IL-4, and TGF-I^ Confers Susceptibility to Vogt-Koyanagi-Harada Disease in Han Chinese. ( 28278322 )
2017
39
Vogt-Koyanagi-Harada disease in a patient of chronic myeloid leukemia. ( 28574001 )
2017
40
Increased Complement 3a Receptor is Associated with Behcet's disease and Vogt-Koyanagi-Harada disease. ( 29138505 )
2017
41
Bilateral Iris Depigmentation and Ocular Hypotony as End-Stage Manifestations of Untreated Vogt-Koyanagi-Harada Disease. ( 28548582 )
2017
42
Expression and role of interleukin-9 in Vogt-Koyanagi-Harada disease. ( 28761327 )
2017
43
Evaluation of Vestibular Functions in Patients with Vogt-Koyanagi-Harada Disease. ( 29080887 )
2017
44
Vogt-Koyanagi-Harada disease-like posterior uveitis in the course of nivolumab (anti-PD-1 antibody), interposed by vemurafenib (BRAF inhibitor), for metastatic cutaneous malignant melanoma. ( 28469878 )
2017
45
Clinical spectrum and management options in Vogt-Koyanagi-Harada disease. ( 28848322 )
2017
46
Optical Coherence Tomography Angiography: Employing a Novel Technique for Investigation in Vogt-Koyanagi-Harada Disease. ( 28868031 )
2017
47
Unilateral Ocular Manifestations of Vogt-Koyanagi-Harada Disease. ( 29020488 )
2017
48
Photoreceptor Cell Injury Starts in the Initial Stage of Vogt-Koyanagi-Harada Disease. ( 28323511 )
2017
49
Corticotherapy vs. Corticotherapy Plus Immunosuppressive Therapy in Acute Vogt-Koyanagi-Harada Disease. ( 29258782 )
2017
50
The spectrum of Vogt-Koyanagi-Harada disease in Iran. ( 28260142 )
2017

Variations for Vogt-Koyanagi-Harada Disease

Expression for Vogt-Koyanagi-Harada Disease

Search GEO for disease gene expression data for Vogt-Koyanagi-Harada Disease.

Pathways for Vogt-Koyanagi-Harada Disease

Pathways related to Vogt-Koyanagi-Harada Disease according to GeneCards Suite gene sharing:

(show all 30)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.91 HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10
2
Show member pathways
13.25 HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10
3
Show member pathways
13.18 FAS IL10 IL17A IL2RA PTPN22 TGFBR3
4
Show member pathways
12.87 HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
5
Show member pathways
12.87 FAS HLA-A HLA-B IL2RA TLR3
6
Show member pathways
12.52 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10 IL2RA
7
Show member pathways
12.49 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10 IL17A IL2RA
8
Show member pathways
12.45 HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
9
Show member pathways
12.29 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL2RA
10
Show member pathways
12.25 HLA-DQA1 HLA-DQB1 HLA-DRB1 PTPN22
11
Show member pathways
12.25 FAS HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
12 12.21 HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1 IL2RA
13 12.21 FAS IL10 IL17A IL2RA NLRP1 PTPN22
14
Show member pathways
12.17 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10
15 12.14 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10
16
Show member pathways
12.14 HLA-A HLA-B IL10 IL17A IL2RA TGFBR3
17 12.04 FAS HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
18
Show member pathways
12.02 FAS HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
19 11.98 HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
20
Show member pathways
11.94 IL10 IL17A TLR3
21 11.92 HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
22
Show member pathways
11.89 HLA-DQA1 HLA-DQB1 HLA-DRB1 PTPN22
23
Show member pathways
11.86 HLA-A HLA-DRB1 IL2RA
24 11.81 HLA-DQA1 HLA-DQB1 HLA-DRB1
25 11.81 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL2RA
26 11.77 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL17A
27 11.7 IL10 IL17A IL2RA
28 11.65 HLA-DQA1 HLA-DQB1 HLA-DRB1 PTPN22
29 11.48 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10
30 10.29 TYR TYRP1

GO Terms for Vogt-Koyanagi-Harada Disease

Cellular components related to Vogt-Koyanagi-Harada Disease according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 Golgi membrane GO:0000139 9.88 HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1 TLR3
2 external side of plasma membrane GO:0009897 9.86 HLA-DRB1 IL17A IL2RA TGFBR3
3 lysosomal membrane GO:0005765 9.84 HLA-DQA1 HLA-DQB1 HLA-DRB1 TLR3
4 cell surface GO:0009986 9.8 FAS HLA-A HLA-B HLA-DRB1 IL2RA TGFBR3
5 endosome membrane GO:0010008 9.77 HLA-DQA1 HLA-DQB1 HLA-DRB1 TLR3 TYRP1
6 melanosome GO:0042470 9.72 PMEL TYR TYRP1
7 trans-Golgi network membrane GO:0032588 9.69 HLA-DQA1 HLA-DQB1 HLA-DRB1
8 endocytic vesicle membrane GO:0030666 9.63 HLA-DQA1 HLA-DQB1 HLA-DRB1
9 transport vesicle membrane GO:0030658 9.61 HLA-DQA1 HLA-DQB1 HLA-DRB1
10 melanosome membrane GO:0033162 9.52 TYR TYRP1
11 MHC class II protein complex GO:0042613 9.5 HLA-DQA1 HLA-DQB1 HLA-DRB1
12 MHC class I protein complex GO:0042612 9.48 HLA-A HLA-B
13 clathrin-coated endocytic vesicle membrane GO:0030669 9.46 HLA-DQA1 HLA-DQB1 HLA-DRB1 TYRP1
14 ER to Golgi transport vesicle membrane GO:0012507 9.35 HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
15 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.02 HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
16 integral component of membrane GO:0016021 10.27 FAS HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1

Biological processes related to Vogt-Koyanagi-Harada Disease according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.88 IL10 IL17A NLRP1 TLR3
2 immune system process GO:0002376 9.86 HLA-A HLA-B HLA-DQA1 HLA-DRB1 IL2RA NLRP1
3 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.73 HLA-DQA1 HLA-DQB1 HLA-DRB1
4 T cell receptor signaling pathway GO:0050852 9.71 HLA-DQA1 HLA-DQB1 HLA-DRB1 PTPN22
5 negative regulation of T cell proliferation GO:0042130 9.63 HLA-DRB1 IL10 IL2RA
6 melanosome organization GO:0032438 9.57 PMEL TYRP1
7 inflammatory response to antigenic stimulus GO:0002437 9.55 HLA-DRB1 IL2RA
8 interferon-gamma-mediated signaling pathway GO:0060333 9.55 HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
9 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.54 HLA-A HLA-B
10 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.54 HLA-DQA1 HLA-DQB1 HLA-DRB1
11 antigen processing and presentation of endogenous peptide antigen via MHC class Ib GO:0002476 9.52 HLA-A HLA-B
12 necroptotic signaling pathway GO:0097527 9.51 FAS TLR3
13 melanin biosynthetic process GO:0042438 9.5 PMEL TYR TYRP1
14 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.49 HLA-DQB1 HLA-DRB1
15 protection from natural killer cell mediated cytotoxicity GO:0042270 9.48 HLA-A HLA-B
16 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.43 HLA-DQB1 HLA-DRB1
17 antigen processing and presentation GO:0019882 9.35 HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
18 immune response GO:0006955 9.32 FAS HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1

Molecular functions related to Vogt-Koyanagi-Harada Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MHC class II receptor activity GO:0032395 9.13 HLA-DQA1 HLA-DQB1 HLA-DRB1
2 peptide antigen binding GO:0042605 9.02 HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1

Sources for Vogt-Koyanagi-Harada Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
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30 HGMD
31 HMDB
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62 PubMed
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69 SNOMED-CT via HPO
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71 TGDB
72 Tocris
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74 UMLS via Orphanet
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