Vogt-Koyanagi-Harada Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: VGT001 MIFTS: 59	Vogt-Koyanagi-Harada Disease Categories: Eye diseases, Immune diseases, Neuronal diseases, Rare diseases, Skin diseases
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Aliases & Classifications for Vogt-Koyanagi-Harada Disease

MalaCards integrated aliases for Vogt-Koyanagi-Harada Disease:

Name: Vogt-Koyanagi-Harada Disease ¹² ⁵³ ⁵⁹ ⁵⁵ ¹⁵

Uveomeningoencephalitic Syndrome ¹² ⁴⁴ ⁷³

Vogt-Koyanagi-Harada Syndrome ⁵³ ³⁷

Uveomenigitic Syndrome ⁵³ ⁵⁹

Vogt-Koyanagi Syndrome ¹²

Harada's Disease ¹²

Vkh Syndrome ⁵³

Vkh Disease ⁵³

Characteristics:

Orphanet epidemiological data:

⁵⁹

vogt-koyanagi-harada disease
Inheritance: Multigenic/multifactorial; Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Neuronal diseases Eye diseases Immune diseases Skin diseases

See all MalaCards categories (disease lists)

ICD10: ³⁴

Diseases of the eye and adnexa

Disorders of choroid and retina

Chorioretinal inflammation

Other chorioretinal inflammations

Disorders of sclera, cornea, iris and ciliary body

Iridocyclitis

Other iridocyclitis

Orphanet: ⁵⁹

Rare neurological diseases

Rare eye diseases

External Ids:

Disease Ontology ¹² DOID:12297

ICD10 ³³ H20.82 H30.81

ICD9CM ³⁵ 363.22 364.24

MeSH ⁴⁴ D014607

NCIt ⁵⁰ C85218

SNOMED-CT ⁶⁸ 44923005 47230004

Orphanet ⁵⁹ ORPHA3437

ICD10 via Orphanet ³⁴ H20.8 H30.8

UMLS via Orphanet ⁷⁴ C0042170

KEGG ³⁷ H01504

SNOMED-CT via HPO ⁶⁹ 60700002 23986001 246635007 more

UMLS ⁷³ C0042170

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Summaries for Vogt-Koyanagi-Harada Disease

NIH Rare Diseases : ⁵³ Vogt-Koyanagi-Harada disease (VKH disease) is a disease that affects several parts of the body, including the eyes, ears, nervous system, and skin. The signs and symptoms of VKH disease are caused by chronic inflammation of melanocytes. Melanocytes are specialized cells that produce a pigment called melanin. Melanin is the substance that gives skin, hair, and eyes their color. Melanin is also found in other parts of the body, such as the retina of the eyes, where it plays a role in normal vision, and in the inner ear, where it is thought to be involved in hearing. People with VKH disease usually develop vision and hearing problems first, followed by signs of skin problems. The most common symptoms include headaches, inflammation of all layers of the colored part of the eye (panuveitis), white patches of skin (vitiligo), hair loss (alopecia), dizziness and nausea (inner ear related problems), and vision and hearing loss. Neurological symptoms may also occur. The exact cause of VKH disease is not well understood, but research suggests it is an autoimmune disease. It is more common in people with darker skin color including Asian, Middle Eastern, Hispanic, and Native American populations. The disease is treated with corticosteroids and other medications.

MalaCards based summary : Vogt-Koyanagi-Harada Disease, also known as uveomeningoencephalitic syndrome, is related to uveitis and pars planitis. An important gene associated with Vogt-Koyanagi-Harada Disease is PTPN22 (Protein Tyrosine Phosphatase, Non-Receptor Type 22), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Bevacizumab and Angiogenesis Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and retina, and related phenotypes are cataract and sensorineural hearing impairment

Disease Ontology : ¹² An autoimmune hypersensitivity disease that is caused by T helper cell mediated autoimmune attack of melanocytes resulting in inflammation of the inside of the eye, whitening of hair, skin pigment loss, and meningitis.

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Related Diseases for Vogt-Koyanagi-Harada Disease

Diseases related to Vogt-Koyanagi-Harada Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 205)

#	Related Disease	Score	Top Affiliating Genes
1	uveitis	31.3	HLA-B IL10 IL17A IL2RA
2	pars planitis	30.9	HLA-A HLA-B HLA-DRB1
3	halo nevi	30.7	HLA-DRB1 PMEL TYR
4	anterior uveitis	30.5	HLA-A HLA-B IL2RA PTPN22
5	alopecia areata	30.4	HLA-A HLA-DQA1 IL17A IL2RA PTPN22
6	herpes zoster	30.4	HLA-A HLA-B IL10
7	graves' disease	30.3	FAS HLA-DQA1 HLA-DRB1 IL2RA PTPN22
8	vitiligo-associated multiple autoimmune disease susceptibility 1	30.2	NLRP1 PMEL PTPN22 TYR TYRP1
9	panuveitis	30.1	HLA-A HLA-B HLA-DQB1 HLA-DRB1 IL10 IL17A
10	arthritis	30.0	HLA-DQB1 HLA-DRB1 IL10 IL17A NLRP1 PTPN22
11	diabetes mellitus	29.8	FAS HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
12	rheumatoid arthritis	29.5	HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10 IL17A
13	autoimmune disease	29.2	FAS HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10
14	alezzandrini syndrome	11.6
15	hepatitis	10.8
16	retinal detachment	10.8
17	hepatitis c	10.8
18	melanoma	10.7
19	headache	10.7
20	sympathetic ophthalmia	10.7
21	leukemia	10.6
22	scleritis	10.6
23	central serous chorioretinopathy	10.6
24	aseptic meningitis	10.5
25	ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus	10.5
26	alopecia	10.5
27	lymphoma	10.5
28	posterior scleritis	10.5
29	neuropathy	10.5
30	acute posterior multifocal placoid pigment epitheliopathy	10.5
31	cataract	10.5
32	lymphocytic leukemia	10.5
33	meningoencephalitis	10.5
34	choroiditis	10.5
35	optic neuritis	10.5
36	posterior uveitis	10.5
37	acute closed-angle glaucoma	10.5
38	neuritis	10.5
39	optic nerve disease	10.5
40	myeloid leukemia	10.5
41	psoriasis	10.5
42	viral infectious disease	10.5
43	meningitis	10.5
44	degos 'en cocarde' erythrokeratoderma	10.5
45	homocysteinemia	10.3
46	tubulointerstitial nephritis with uveitis	10.3
47	brain meningioma	10.3
48	common variable immunodeficiency	10.3
49	intraocular lymphoma	10.3
50	keratopathy	10.3

Graphical network of the top 20 diseases related to Vogt-Koyanagi-Harada Disease:

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Symptoms & Phenotypes for Vogt-Koyanagi-Harada Disease

Human phenotypes related to Vogt-Koyanagi-Harada Disease:

⁵⁹ ³² (show all 16)

#	Description	HPO Frequency	Orphanet Frequency	HPO Source Accession
1	cataract ⁵⁹ ³²	frequent (33%)	Frequent (79-30%)	HP:0000518
2	sensorineural hearing impairment ⁵⁹ ³²	hallmark (90%)	Very frequent (99-80%)	HP:0000407
3	visual impairment ⁵⁹ ³²	frequent (33%)	Frequent (79-30%)	HP:0000505
4	short stature ⁵⁹ ³²	frequent (33%)	Frequent (79-30%)	HP:0004322
5	cognitive impairment ⁵⁹ ³²	hallmark (90%)	Very frequent (99-80%)	HP:0100543
6	vitiligo ⁵⁹ ³²	hallmark (90%)	Very frequent (99-80%)	HP:0001045
7	hypopigmented skin patches ⁵⁹ ³²	hallmark (90%)	Very frequent (99-80%)	HP:0001053
8	premature graying of hair ⁵⁹ ³²	hallmark (90%)	Very frequent (99-80%)	HP:0002216
9	glaucoma ⁵⁹ ³²	frequent (33%)	Frequent (79-30%)	HP:0000501
10	retinal detachment ⁵⁹ ³²	frequent (33%)	Frequent (79-30%)	HP:0000541
11	sparse scalp hair ⁵⁹ ³²	hallmark (90%)	Very frequent (99-80%)	HP:0002209
12	poliosis ⁵⁹ ³²	hallmark (90%)	Very frequent (99-80%)	HP:0002290
13	abnormality of the eyelashes ⁵⁹		Very frequent (99-80%)
14	abnormality of the eyebrow ⁵⁹		Very frequent (99-80%)
15	abnormal eyelash morphology ³²	hallmark (90%)		HP:0000499
16	abnormal eyebrow morphology ³²	hallmark (90%)		HP:0000534

GenomeRNAi Phenotypes related to Vogt-Koyanagi-Harada Disease according to GeneCards Suite gene sharing:

²⁶ (show all 30)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-103	10.27	HLA-A HLA-B
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-110	10.27	HLA-A HLA-B HLA-DQA1
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-115	10.27	IL2RA
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-118	10.27	HLA-A HLA-B
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-121	10.27	HLA-DQA1 IL2RA
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-130	10.27	IL2RA
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-138	10.27	IL2RA
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-149	10.27	HLA-DQA1
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-156	10.27	HLA-A HLA-B
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-169	10.27	IL2RA
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-174	10.27	IL2RA
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-178	10.27	HLA-A HLA-B
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-185	10.27	IL2RA
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-19	10.27	HLA-A HLA-B HLA-DQA1 IL2RA
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-2	10.27	IL2RA
16	Increased shRNA abundance (Z-score > 2)	GR00366-A-202	10.27	IL2RA
17	Increased shRNA abundance (Z-score > 2)	GR00366-A-25	10.27	IL2RA
18	Increased shRNA abundance (Z-score > 2)	GR00366-A-31	10.27	HLA-A HLA-B
19	Increased shRNA abundance (Z-score > 2)	GR00366-A-45	10.27	HLA-DQA1
20	Increased shRNA abundance (Z-score > 2)	GR00366-A-46	10.27	IL2RA
21	Increased shRNA abundance (Z-score > 2)	GR00366-A-50	10.27	IL2RA
22	Increased shRNA abundance (Z-score > 2)	GR00366-A-52	10.27	IL2RA
23	Increased shRNA abundance (Z-score > 2)	GR00366-A-67	10.27	IL2RA
24	Increased shRNA abundance (Z-score > 2)	GR00366-A-7	10.27	HLA-A HLA-B
25	Increased shRNA abundance (Z-score > 2)	GR00366-A-73	10.27	HLA-DQA1
26	Increased shRNA abundance (Z-score > 2)	GR00366-A-74	10.27	HLA-A HLA-B
27	Increased shRNA abundance (Z-score > 2)	GR00366-A-9	10.27	IL2RA
28	Increased shRNA abundance (Z-score > 2)	GR00366-A-99	10.27	HLA-DQA1
29	Synthetic lethal with MLN4924 (a NAE inhibitor)	GR00250-A-1	9.77	FAS HLA-DQB1 IL10 IL17A IL2RA NLRP1
30	Synthetic lethal with MLN4924 (a NAE inhibitor)	GR00250-A-2	9.77	FAS HLA-DQB1 IL10 IL17A IL2RA NLRP1

MGI Mouse Phenotypes related to Vogt-Koyanagi-Harada Disease:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	10.03	FAS HLA-DQA1 HLA-DQB1 IL10 IL17A IL2RA
2	endocrine/exocrine gland	MP:0005379	9.97	FAS HLA-DQA1 HLA-DQB1 IL10 IL17A IL2RA
3	homeostasis/metabolism	MP:0005376	9.9	FAS HLA-DQB1 IL10 IL17A IL2RA NLRP1
4	immune system	MP:0005387	9.7	FAS HLA-DQA1 HLA-DQB1 IL10 IL17A IL2RA
5	respiratory system	MP:0005388	9.17	FAS HLA-DQB1 IL10 IL17A IL2RA PTPN22

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Drugs & Therapeutics for Vogt-Koyanagi-Harada Disease

Drugs for Vogt-Koyanagi-Harada Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Bevacizumab

Approved, Investigational

Phase 3,Not Applicable

216974-75-3

Angiogenesis Inhibitors

Phase 3,Not Applicable

Angiogenesis Modulating Agents

Phase 3,Not Applicable

Povidone-iodine

Approved

Not Applicable

25655-41-8

Povidone

Approved

Not Applicable

9003-39-8

Iodine

Approved, Investigational

Not Applicable

7553-56-2

807

Azathioprine

Approved

Not Applicable

446-86-6

2265

Mycophenolic acid

Approved

Not Applicable

24280-93-1

446541

Miconazole

Approved, Investigational, Vet_approved

Not Applicable

22916-47-8

4189

Infliximab

Approved

170277-31-3

Methotrexate

Approved

59-05-2, 1959-05-2

126941

Prednisolone

Approved, Vet_approved

50-24-8

5755

rituximab

Approved

174722-31-7

10201696

Etanercept

Approved, Investigational

185243-69-0

Methylprednisolone

Approved, Vet_approved

83-43-2

6741

Adalimumab

Approved

331731-18-1

16219006

Methylprednisolone hemisuccinate

Approved

2921-57-5

Prednisolone phosphate

Approved, Vet_approved

302-25-0

Prednisolone hemisuccinate

Experimental

2920-86-7

Immunosuppressive Agents

Not Applicable

Calcineurin Inhibitors

Not Applicable

Anti-Bacterial Agents

Not Applicable

Dermatologic Agents

Not Applicable

Immunologic Factors

Not Applicable

Cyclosporins

Not Applicable

Anti-Infective Agents

Not Applicable

Antifungal Agents

Not Applicable

Antibiotics, Antitubercular

Not Applicable

Antirheumatic Agents

Not Applicable

cadexomer iodine

Not Applicable

Prednisolone acetate

Methylprednisolone acetate

Antitubercular Agents

Antimetabolites

Antimetabolites, Antineoplastic

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Intravitreal Bevacizumab for Inflammatory Neovascular Membranes	Completed	NCT00407121	Phase 3	Bevacizumab
2	Intravitreal Bevacizumab for the Treatment of CNV in VKH Disease - A Prospective Study	Unknown status	NCT02015351	Not Applicable	bevacizumab
3	Causes of Visual Loss in Retinal Disease	Unknown status	NCT01613963		Immunosuppressive Agents
4	Multimodal Analysis and Electroretinogram in VKH From Acute Onset - Part I	Completed	NCT03811366	Not Applicable	Meticorten
5	Early Immunosuppressive Therapy on the Course of Vogt-Koyanagi-Harada Disease	Recruiting	NCT03399175	Not Applicable	Early high-dose corticosteroid and immunosuppressive therapy

Search NIH Clinical Center for Vogt-Koyanagi-Harada Disease

Cochrane evidence based reviews: uveomeningoencephalitic syndrome

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Genetic Tests for Vogt-Koyanagi-Harada Disease

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Anatomical Context for Vogt-Koyanagi-Harada Disease

MalaCards organs/tissues related to Vogt-Koyanagi-Harada Disease:

⁴¹

Eye, Skin, Retina, T Cells, Myeloid, Ovary, Lung

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Publications for Vogt-Koyanagi-Harada Disease

Articles related to Vogt-Koyanagi-Harada Disease:

(show top 50) (show all 444)

#	Title	Authors	Year
1	Association of Long Noncoding RNAs Polymorphisms With Ankylosing Spondylitis, Vogt-Koyanagi-Harada Disease, and Behcet's Disease. ( 29490353 )	Yue Y....Hou S.	2018
2	Clinical features and visual outcomes of 111 patients with new-onset acute Vogt-Koyanagi-Harada disease treated with pulse intravenous corticosteroids. ( 29666121 )	Nakayama M....Okada A.A.	2018
3	Novel treatment regimen of Vogt-Koyanagi-Harada disease with a reduced dose of corticosteroids combined with immunosuppressive agents. ( 29111815 )	Yang P....Kijlstra A.	2018
4	Retinal Pigment Epithelium Detachment in Acute Vogt-Koyanagi-Harada Disease: An Unusual Finding at Presentation. ( 29513616 )	Khochtali S....Khairallah M.	2018
5	Recovery of macular cone photoreceptors in Vogt-Koyanagi-Harada disease. ( 29264653 )	Nakamura T....Oiwake T.	2018
6	Vogt-Koyanagi-Harada disease: study of 14 cases. ( 29731134 )	Espinosa-Barberi G....Francisco HernA!ndez F.	2018
7	Development and Evaluation of Diagnostic Criteria for Vogt-Koyanagi-Harada Disease. ( 29978190 )	Yang P....Kijlstra A.	2018
8	Changes in Central Macular Thickness and Retinal Nerve Fiber Layer Thickness in Eyes with Vogt-Koyanagi-Harada Disease: A 2-Year Follow-Up Study. ( 29339644 )	Han Y.S....Kim J.Y.	2018
9	Association of human leukocyte antigen (HLA)-DQ and HLA-DQA1/DQB1 alleles with Vogt-Koyanagi-Harada disease: A systematic review and meta-analysis. ( 29443768 )	Liu B....Zhong J.	2018
10	Longitudinal observation of subretinal fibrosis in Vogt-Koyanagi-Harada disease. ( 29334924 )	Zhao C....Zhang M.	2018
11	Vogt-Koyanagi-Harada Disease Presenting as Unilateral Neuroretinits. ( 29467803 )	Pellegrini F....Prosdocimo G.	2018
12	Diagnostic Function of 3D Optical Coherence Tomography Images in Diagnosis of Vogt-Koyanagi-Harada Disease at Acute Uveitis Stage. ( 29396390 )		2018
13	HLA-DRB1*04:05 in two cases of Vogt-Koyanagi-Harada disease-like uveitis developing from an advanced melanoma patient treated by sequential administration of nivolumab and dabrafenib/trametinib therapy. ( 29488243 )		2018
14	Acquired myopia in Vogt-Koyanagi-Harada disease. ( 29397539 )		2018
15	Vogt-Koyanagi-Harada disease-like uveitis induced by vemurafenib for metastatic cutaneous malignant melanoma. ( 29314171 )		2018
16	Vogt-Koyanagi-Harada Disease Associated with Influenza A Virus Infection: A Case Report. ( 29321438 )		2018
17	MR findings of the orbit in patients with Vogt-Koyanagi-Harada disease. ( 29476208 )		2018
18	Vogt-Koyanagi-Harada disease like presentation in patients with chronic myeloid leukemia. ( 29780937 )		2018
19	Vogt-Koyanagi-Harada Disease Associated with Hepatitis B Vaccination. ( 29953303 )		2018
20	Improving the Diagnostic Criteria for Vogt-Koyanagi-Harada Disease. ( 29978179 )		2018
21	Rare association between Vogt-Koyanagi-Harada disease and rheumatoid arthritis: Report of a clinical case from the unit of multidisciplinary uveitis. ( 29519769 )		2018
22	MicroRNA-20a-5p suppresses IL-17 production by targeting OSM and CCL1 in patients with Vogt-Koyanagi-Harada disease. ( 28972028 )		2018
23	TUBERCULOUS CHOROIDITIS IN PATIENT WITH VOGT-KOYANAGI-HARADA DISEASE. ( 30074567 )	Anderson EW...Goldberg NR	2018
24	Probable Vogt-Koyanagi-Harada disease with granulomatous tattoo-related dermatitis. ( 30340735 )	Gill I...Fielden M	2018
25	A case of Vogt-Koyanagi-Harada disease as a sequela of drug reaction with eosinophilia and systemic symptoms. ( 30306111 )	Altman K...Shinohara M	2018
26	Incomplete Vogt-Koyanagi-Harada disease following treatment with encorafenib and binimetinib for metastatic melanoma. ( 30169430 )	Diamantopoulos PT...Gogas H	2018
27	Unusual Case of Vogt-Koyanagi-Harada Disease Associated with SAPHO Syndrome: A Case Report. ( 29681837 )	Hasegawa M...Kamei M	2018
28	A challenging case of tuberculosis-associated uveitis after corticosteroid treatment for Vogt-Koyanagi-Harada disease. ( 30140653 )	Qian TW...Xu X	2018
29	Contribution of dual fluorescein and indocyanine green angiography to the appraisal of posterior involvement in birdshot retinochoroiditis and Vogt-Koyanagi-Harada disease. ( 28299496 )	Balci O...Herbort CP	2018
30	Multispectral image analysis in Vogt-Koyanagi-Harada disease. ( 29220112 )	Huang G...Yang P	2018
31	Longitudinal Study of Visual Function in Vogt-Koyanagi-Harada Disease Using Full-Field Electroretinography. ( 29702075 )	Yuan W...Yang P	2018
32	Long term treatment with infliximab in pediatric Vogt-Koyanagi-Harada disease. ( 29998211 )	Budmann GA...Pringe A	2018
33	Ultra-wide-field angiography findings in acute Vogt-Koyanagi-Harada disease. ( 30100554 )	Kim P...Ham DI	2018
34	Optical Coherence Tomography Angiography for Evaluation of Sattler's Layer in Vogt-Koyanagi-Harada Disease. ( 30114311 )	Wintergerst MWM...Finger RP	2018
35	Disabled-2 (DAB2) Overexpression Inhibits Monocyte-Derived Dendritic Cells' Function in Vogt-Koyanagi-Harada Disease. ( 30267088 )	Yi S...Yang P	2018
36	Association Study of ARMC9 Gene Variants with Vogt-Koyanagi-Harada Disease in Japanese Patients. ( 30395750 )	Ohno T...Mizuki N	2018
37	Polarization-Sensitive Optical Coherence Tomographic Documentation of Choroidal Melanin Loss in Chronic Vogt-Koyanagi-Harada Disease. ( 28863408 )	Miura M....Goto H.	2017
38	Promoter Hypermethylation of GATA3, IL-4, and TGF-I^ Confers Susceptibility to Vogt-Koyanagi-Harada Disease in Han Chinese. ( 28278322 )	Zhu Y....Yang P.	2017
39	Vogt-Koyanagi-Harada disease in a patient of chronic myeloid leukemia. ( 28574001 )	Chawla R....Vohra R.	2017
40	Increased Complement 3a Receptor is Associated with Behcet's disease and Vogt-Koyanagi-Harada disease. ( 29138505 )	Wang C....Yang P.	2017
41	Bilateral Iris Depigmentation and Ocular Hypotony as End-Stage Manifestations of Untreated Vogt-Koyanagi-Harada Disease. ( 28548582 )	Cuevas M....CA^rdoba A.	2017
42	Expression and role of interleukin-9 in Vogt-Koyanagi-Harada disease. ( 28761327 )	Peng Z....Wang Q.	2017
43	Evaluation of Vestibular Functions in Patients with Vogt-Koyanagi-Harada Disease. ( 29080887 )	Fujiwara K....Homma A.	2017
44	Vogt-Koyanagi-Harada disease-like posterior uveitis in the course of nivolumab (anti-PD-1 antibody), interposed by vemurafenib (BRAF inhibitor), for metastatic cutaneous malignant melanoma. ( 28469878 )	Matsuo T....Yamasaki O.	2017
45	Clinical spectrum and management options in Vogt-Koyanagi-Harada disease. ( 28848322 )	Lodhi S.A....Peram V.	2017
46	Optical Coherence Tomography Angiography: Employing a Novel Technique for Investigation in Vogt-Koyanagi-Harada Disease. ( 28868031 )	Giannakouras P....Diagourtas A.	2017
47	Unilateral Ocular Manifestations of Vogt-Koyanagi-Harada Disease. ( 29020488 )	Tsui E....Barbazetto I.	2017
48	Photoreceptor Cell Injury Starts in the Initial Stage of Vogt-Koyanagi-Harada Disease. ( 28323511 )	Zhu R....Yang L.	2017
49	Corticotherapy vs. Corticotherapy Plus Immunosuppressive Therapy in Acute Vogt-Koyanagi-Harada Disease. ( 29258782 )	Concha-Del RA-o L.E....Arellanes-GarcA-a L.	2017
50	The spectrum of Vogt-Koyanagi-Harada disease in Iran. ( 28260142 )	Hedayatfar A....Soheilian M.	2017

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Genes for Vogt-Koyanagi-Harada Disease

Genes related to Vogt-Koyanagi-Harada Disease (2 elite genes):

(show all 17)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	PTPN22	Protein Tyrosine Phosphatase, Non-Receptor Type 22	Protein Coding	46.38	Susceptibility factor ⁵⁹ DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	TYR	Tyrosinase	Protein Coding	30.16	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	9510558
3	HLA-DRB1	Major Histocompatibility Complex, Class II, DR Beta 1	Protein Coding	30.15	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	7906684 15603876
4	FAS	Fas Cell Surface Death Receptor	Protein Coding	29.24	Susceptibility factor ⁵⁹ Novoseek inferred ⁵⁵	11815887 15454035 9646088 (more) 8654110 9400790
5	ARMC9	Armadillo Repeat Containing 9	Protein Coding	23.51	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	IL2RA	Interleukin 2 Receptor Subunit Alpha	Protein Coding	22.74	Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	10342043 1635294
7	IL17A	Interleukin 17A	Protein Coding	22.45	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
8	HLA-DQA1	Major Histocompatibility Complex, Class II, DQ Alpha 1	Protein Coding	22.43	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	HLA-A	Major Histocompatibility Complex, Class I, A	Protein Coding	22.37	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
10	HLA-DQB1	Major Histocompatibility Complex, Class II, DQ Beta 1	Protein Coding	22.26	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
11	HLA-B	Major Histocompatibility Complex, Class I, B	Protein Coding	22.25	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
12	PMEL	Premelanosome Protein	Protein Coding	21.76	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
13	TYRP1	Tyrosinase Related Protein 1	Protein Coding	21.54	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
14	TGFBR3	Transforming Growth Factor Beta Receptor 3	Protein Coding	21.23	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
15	NLRP1	NLR Family Pyrin Domain Containing 1	Protein Coding	20.98	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
16	IL10	Interleukin 10	Protein Coding	20.95	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
17	TLR3	Toll Like Receptor 3	Protein Coding	20.83	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)

Sources

Variations for Vogt-Koyanagi-Harada Disease

Sources

Expression for Vogt-Koyanagi-Harada Disease

Search GEO for disease gene expression data for Vogt-Koyanagi-Harada Disease.

Sources

Pathways for Vogt-Koyanagi-Harada Disease

Pathways related to Vogt-Koyanagi-Harada Disease according to GeneCards Suite gene sharing:

(show all 30)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.91	HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10
2	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	13.25	HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10
3	PAK Pathway ⁶⁴ Show member pathways Antioxidant Action of Vitamin-C ⁶⁴ Epithelial Adherens Junctions ⁶⁴	13.18	FAS IL10 IL17A IL2RA PTPN22 TGFBR3
4	Actin Nucleation by ARP-WASP Complex ⁶⁴ Show member pathways Actin Nucleation and Branching ⁶⁴ CDC42 Pathway ⁶⁴ RhoA Pathway ⁶⁴	12.87	HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
5	PI3K-Akt signaling pathway ³⁷ Show member pathways Human papillomavirus infection ³⁷	12.87	FAS HLA-A HLA-B IL2RA TLR3
6	Immune response NFAT in immune response ²² Show member pathways Immune response CD28 signaling ²² Immune response ICOS pathway in T-helper cell ²² Immune response T cell receptor signaling pathway ²²	12.52	HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10 IL2RA
7	Th17 cell differentiation ³⁷ Show member pathways IL-22 Pathway ⁶⁴ Immune response IL-22 signaling pathway ²² Inflammatory bowel disease (IBD) ³⁷ Th1 and Th2 cell differentiation ³⁷	12.49	HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10 IL17A IL2RA
8	Interferon gamma signaling ⁶⁶ Show member pathways Interferon Signaling ⁶⁶ Regulation of IFNG signaling ⁶⁶	12.45	HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
9	ICos-ICosL Pathway in T-Helper Cell ⁶⁴ Show member pathways Calcium Mediated T-Cell Apoptosis ⁶⁴ CD28 Signaling in T-Helper Cell ⁶⁴	12.29	HLA-DQA1 HLA-DQB1 HLA-DRB1 IL2RA
10	TCR signaling (REACTOME) ⁶⁶ Show member pathways Downstream TCR signaling ⁶⁶	12.25	HLA-DQA1 HLA-DQB1 HLA-DRB1 PTPN22
11	Influenza A ³⁷ Show member pathways Herpes simplex infection ³⁷ Measles ³⁷	12.25	FAS HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
12	Human T-cell leukemia virus 1 infection ³⁷	12.21	HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1 IL2RA
13	NF-kappaB Signaling ⁴	12.21	FAS IL10 IL17A IL2RA NLRP1 PTPN22
14	Toxoplasmosis ³⁷ Show member pathways Leishmaniasis ³⁷	12.17	HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10
15	Tuberculosis ³⁷	12.14	HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10
16	Immune response IFN alpha/beta signaling pathway ²² Show member pathways Cytokine Network ⁶⁴ Interferon alpha/beta signaling ⁶⁶ Regulation of IFNA signaling ⁶⁶	12.14	HLA-A HLA-B IL10 IL17A IL2RA TGFBR3
17	Epstein-Barr virus infection ³⁷	12.04	FAS HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
18	Allograft rejection ¹ ³⁷ Show member pathways Antigen processing and presentation ³⁷ Asthma ³⁷ Autoimmune thyroid disease ³⁷ CTL Mediated Apoptosis ⁶⁴ Graft-versus-host disease ³⁷ Intestinal immune network for IgA production ³⁷ THC Differentiation Pathway ⁶⁴ Type I diabetes mellitus ³⁷ Viral myocarditis ³⁷	12.02	FAS HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
19	Phagosome ³⁷	11.98	HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
20	Th1 Differentiation Pathway ⁶⁵ Show member pathways IL27-mediated signaling events ¹ Th17 Differentiation Pathway ⁶⁵	11.94	IL10 IL17A TLR3
21	Cell adhesion molecules (CAMs) ³⁷	11.92	HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
22	Translocation of ZAP-70 to Immunological synapse ⁶⁶ Show member pathways Generation of second messenger molecules ⁶⁶ PD-1 signaling ⁶⁶ Phosphorylation of CD3 and TCR zeta chains ⁶⁶	11.89	HLA-DQA1 HLA-DQB1 HLA-DRB1 PTPN22
23	IL12-mediated signaling events ¹ Show member pathways Immune response IL-12-induced IFN-gamma production ²²	11.86	HLA-A HLA-DRB1 IL2RA
24	MHC class II antigen presentation ⁶⁶	11.81	HLA-DQA1 HLA-DQB1 HLA-DRB1
25	Hematopoietic cell lineage ³⁷	11.81	HLA-DQA1 HLA-DQB1 HLA-DRB1 IL2RA
26	Rheumatoid arthritis ³⁷	11.77	HLA-DQA1 HLA-DQB1 HLA-DRB1 IL17A
27	Innate Lymphoid Cell Differentiation Pathways ⁶⁵	11.7	IL10 IL17A IL2RA
28	CTLA4 Signaling ⁶⁴	11.65	HLA-DQA1 HLA-DQB1 HLA-DRB1 PTPN22
29	Staphylococcus aureus infection ³⁷	11.48	HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10
30	Melanin biosynthesis ⁶⁶	10.29	TYR TYRP1

Sources

GO Terms for Vogt-Koyanagi-Harada Disease

Cellular components related to Vogt-Koyanagi-Harada Disease according to GeneCards Suite gene sharing:

(show all 16)

#	Name	GO ID	Score	Top Affiliating Genes
1	Golgi membrane	GO:0000139	9.88	HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1 TLR3
2	external side of plasma membrane	GO:0009897	9.86	HLA-DRB1 IL17A IL2RA TGFBR3
3	lysosomal membrane	GO:0005765	9.84	HLA-DQA1 HLA-DQB1 HLA-DRB1 TLR3
4	cell surface	GO:0009986	9.8	FAS HLA-A HLA-B HLA-DRB1 IL2RA TGFBR3
5	endosome membrane	GO:0010008	9.77	HLA-DQA1 HLA-DQB1 HLA-DRB1 TLR3 TYRP1
6	melanosome	GO:0042470	9.72	PMEL TYR TYRP1
7	trans-Golgi network membrane	GO:0032588	9.69	HLA-DQA1 HLA-DQB1 HLA-DRB1
8	endocytic vesicle membrane	GO:0030666	9.63	HLA-DQA1 HLA-DQB1 HLA-DRB1
9	transport vesicle membrane	GO:0030658	9.61	HLA-DQA1 HLA-DQB1 HLA-DRB1
10	melanosome membrane	GO:0033162	9.52	TYR TYRP1
11	MHC class II protein complex	GO:0042613	9.5	HLA-DQA1 HLA-DQB1 HLA-DRB1
12	MHC class I protein complex	GO:0042612	9.48	HLA-A HLA-B
13	clathrin-coated endocytic vesicle membrane	GO:0030669	9.46	HLA-DQA1 HLA-DQB1 HLA-DRB1 TYRP1
14	ER to Golgi transport vesicle membrane	GO:0012507	9.35	HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
15	integral component of lumenal side of endoplasmic reticulum membrane	GO:0071556	9.02	HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
16	integral component of membrane	GO:0016021	10.27	FAS HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1

Biological processes related to Vogt-Koyanagi-Harada Disease according to GeneCards Suite gene sharing:

(show all 18)

#	Name	GO ID	Score	Top Affiliating Genes
1	inflammatory response	GO:0006954	9.88	IL10 IL17A NLRP1 TLR3
2	immune system process	GO:0002376	9.86	HLA-A HLA-B HLA-DQA1 HLA-DRB1 IL2RA NLRP1
3	antigen processing and presentation of exogenous peptide antigen via MHC class II	GO:0019886	9.73	HLA-DQA1 HLA-DQB1 HLA-DRB1
4	T cell receptor signaling pathway	GO:0050852	9.71	HLA-DQA1 HLA-DQB1 HLA-DRB1 PTPN22
5	negative regulation of T cell proliferation	GO:0042130	9.63	HLA-DRB1 IL10 IL2RA
6	melanosome organization	GO:0032438	9.57	PMEL TYRP1
7	inflammatory response to antigenic stimulus	GO:0002437	9.55	HLA-DRB1 IL2RA
8	interferon-gamma-mediated signaling pathway	GO:0060333	9.55	HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
9	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent	GO:0002480	9.54	HLA-A HLA-B
10	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	GO:0002504	9.54	HLA-DQA1 HLA-DQB1 HLA-DRB1
11	antigen processing and presentation of endogenous peptide antigen via MHC class Ib	GO:0002476	9.52	HLA-A HLA-B
12	necroptotic signaling pathway	GO:0097527	9.51	FAS TLR3
13	melanin biosynthetic process	GO:0042438	9.5	PMEL TYR TYRP1
14	humoral immune response mediated by circulating immunoglobulin	GO:0002455	9.49	HLA-DQB1 HLA-DRB1
15	protection from natural killer cell mediated cytotoxicity	GO:0042270	9.48	HLA-A HLA-B
16	immunoglobulin production involved in immunoglobulin mediated immune response	GO:0002381	9.43	HLA-DQB1 HLA-DRB1
17	antigen processing and presentation	GO:0019882	9.35	HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
18	immune response	GO:0006955	9.32	FAS HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1

Molecular functions related to Vogt-Koyanagi-Harada Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	MHC class II receptor activity	GO:0032395	9.13	HLA-DQA1 HLA-DQB1 HLA-DRB1
2	peptide antigen binding	GO:0042605	9.02	HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1

Sources

Sources for Vogt-Koyanagi-Harada Disease

¹ BioSystems

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⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

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⁶¹ PharmGKB

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⁶⁸ SNOMED-CT

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⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

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⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia