MCID: VGT001
MIFTS: 60

Vogt-Koyanagi-Harada Disease

Categories: Rare diseases, Neuronal diseases, Eye diseases, Immune diseases

Aliases & Classifications for Vogt-Koyanagi-Harada Disease

MalaCards integrated aliases for Vogt-Koyanagi-Harada Disease:

Name: Vogt-Koyanagi-Harada Disease 12 53 59 55 15
Uveomeningoencephalitic Syndrome 12 44 73
Vogt-Koyanagi-Harada Syndrome 53 37
Uveomenigitic Syndrome 53 59
Vogt-Koyanagi Syndrome 12
Harada's Disease 12
Vkh Syndrome 53
Vkh Disease 53

Characteristics:

Orphanet epidemiological data:

59
vogt-koyanagi-harada disease
Inheritance: Multigenic/multifactorial; Age of onset: All ages; Age of death: normal life expectancy;

Classifications:



External Ids:

Disease Ontology 12 DOID:12297
ICD10 33 H20.82 H30.81
ICD9CM 35 363.22 364.24
MeSH 44 D014607
NCIt 50 C85218
Orphanet 59 ORPHA3437
ICD10 via Orphanet 34 H20.8 H30.8
UMLS via Orphanet 74 C0042170
KEGG 37 H01504
UMLS 73 C0042170

Summaries for Vogt-Koyanagi-Harada Disease

NIH Rare Diseases : 53 Vogt-Koyanagi-Harada disease (VKH disease) is a disease that affects several parts of the body, including the eyes, ears, nervous system, and skin. The signs and symptoms of VKH disease are caused by chronic inflammation of melanocytes. Melanocytes are specialized cells that produce a pigment called melanin. Melanin is the substance that gives skin, hair, and eyes their color. Melanin is also found in other parts of the body, such as the retina of the eyes, where it plays a role in normal vision, and in the inner ear, where it is thought to be involved in hearing. People with VKH disease usually develop vision and hearing problems first, followed by signs of skin problems. The most common symptoms include headaches, inflammation of all layers of the colored part of the eye (panuveitis), white patches of skin (vitiligo), hair loss (alopecia), dizziness and nausea (inner ear related problems), and vision and hearing loss. Neurological symptoms may also occur. The exact cause of VKH disease is not well understood, but research suggests it is an autoimmune disease. It is more common in people with darker skin color including Asian, Middle Eastern, Hispanic, and Native American populations. The disease is treated with corticosteroids and other medications.

MalaCards based summary : Vogt-Koyanagi-Harada Disease, also known as uveomeningoencephalitic syndrome, is related to uveitis and alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity. An important gene associated with Vogt-Koyanagi-Harada Disease is PTPN22 (Protein Tyrosine Phosphatase, Non-Receptor Type 22), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Bevacizumab and Angiogenesis Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and retina, and related phenotypes are abnormality of the eyelashes and glaucoma

Disease Ontology : 12 A hypersensitivity reaction type II disease that is caused by T helper cell mediated autoimmune attack of melanocytes resulting in inflammation of the inside of the eye, whitening of hair, skin pigment loss, and meningitis.

Wikipedia : 76 Vogt–Koyanagi–Harada disease (VKH), also known as Vogt–Koyanagi–Harada syndrome, uveomeningitis syndrome... more...

Related Diseases for Vogt-Koyanagi-Harada Disease

Diseases related to Vogt-Koyanagi-Harada Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 171)
# Related Disease Score Top Affiliating Genes
1 uveitis 31.0 HLA-B IL10 IL17A IL2RA
2 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 30.6 IL10 IL17A PTPN22
3 anterior uveitis 30.4 HLA-A HLA-B IL2RA PTPN22
4 graves' disease 29.8 FAS HLA-DQA1 HLA-DRB1 IL2RA PTPN22
5 panuveitis 29.7 HLA-B HLA-DQB1 HLA-DRB1 IL10 IL17A
6 arthritis 28.8 HLA-DQB1 HLA-DRB1 IL10 IL17A NLRP1 PTPN22
7 diabetes mellitus 28.1 FAS HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
8 rheumatoid arthritis 27.2 HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10 IL17A
9 autoimmune disease 26.2 FAS HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10
10 alezzandrini syndrome 11.5
11 choroiditis 11.0
12 limbic encephalitis with lgi1 antibodies 10.9 HLA-DQB1 HLA-DRB1
13 retinitis 10.8
14 metal allergy 10.8 HLA-DQB1 HLA-DRB1
15 hypersomnia 10.8 HLA-DQB1 HLA-DRB1
16 lichen planopilaris 10.8 HLA-DQB1 HLA-DRB1
17 beryllium disease 10.8 HLA-DQB1 HLA-DRB1
18 achalasia, familial esophageal 10.8 HLA-DQA1 HLA-DQB1
19 autoimmune pancreatitis 10.7 HLA-DQB1 HLA-DRB1
20 chronic beryllium disease 10.7 HLA-DQB1 HLA-DRB1
21 rheumatoid factor-negative juvenile idiopathic arthritis 10.7 HLA-DRB1 IL2RA PTPN22
22 osteonecrosis of the jaw 10.7 HLA-DQB1 HLA-DRB1 IL17A
23 autoimmune enteropathy 10.7 IL17A IL2RA
24 hepatitis 10.6
25 phenytoin or carbamazepine toxicity 10.6 HLA-A HLA-B
26 hepatitis c 10.6
27 melanotic neurilemmoma 10.6 PMEL TYR
28 focal epithelial hyperplasia 10.6 HLA-DQA1 HLA-DQB1 HLA-DRB1
29 lichen sclerosus 10.6 HLA-DQB1 HLA-DRB1
30 retinal detachment 10.6
31 diffuse meningeal melanocytosis 10.6 PMEL TYR
32 recurrent respiratory papillomatosis 10.6 HLA-DQA1 HLA-DQB1 HLA-DRB1
33 melanoacanthoma 10.6 PMEL TYR
34 juvenile myasthenia gravis 10.6 HLA-DRB1 IL10
35 whipple disease 10.6 HLA-DQB1 HLA-DRB1
36 melanoma 10.6
37 headache 10.6
38 atrial tachyarrhythmia with short pr interval 10.6 HLA-A HLA-B
39 glaucomatocyclitic crisis 10.5 HLA-A HLA-B
40 halo nevi 10.5 HLA-DRB1 PMEL TYR
41 sympathetic ophthalmia 10.5
42 juvenile rheumatoid arthritis 10.5 HLA-DQA1 HLA-DRB1 IL2RA
43 hyperlucent lung 10.5 IL10 IL2RA
44 palindromic rheumatism 10.5 HLA-A HLA-DRB1 PTPN22
45 leukemia 10.5
46 scleritis 10.5
47 malignant spindle cell melanoma 10.5 PMEL TYR
48 idiopathic inflammatory myopathy 10.4 HLA-B HLA-DQA1 HLA-DRB1
49 postherpetic neuralgia 10.4 HLA-A HLA-B HLA-DRB1
50 hermansky-pudlak syndrome 3 10.4 PMEL TYR TYRP1

Graphical network of the top 20 diseases related to Vogt-Koyanagi-Harada Disease:



Diseases related to Vogt-Koyanagi-Harada Disease

Symptoms & Phenotypes for Vogt-Koyanagi-Harada Disease

Human phenotypes related to Vogt-Koyanagi-Harada Disease:

59 32 (show all 15)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 abnormality of the eyelashes 59 32 hallmark (90%) Very frequent (99-80%) HP:0000499
2 glaucoma 59 32 frequent (33%) Frequent (79-30%) HP:0000501
3 visual impairment 59 32 frequent (33%) Frequent (79-30%) HP:0000505
4 cataract 59 32 frequent (33%) Frequent (79-30%) HP:0000518
5 retinal detachment 59 32 frequent (33%) Frequent (79-30%) HP:0000541
6 sensorineural hearing impairment 59 32 hallmark (90%) Very frequent (99-80%) HP:0000407
7 vitiligo 59 32 hallmark (90%) Very frequent (99-80%) HP:0001045
8 hypopigmented skin patches 59 32 hallmark (90%) Very frequent (99-80%) HP:0001053
9 sparse scalp hair 59 32 hallmark (90%) Very frequent (99-80%) HP:0002209
10 premature graying of hair 59 32 hallmark (90%) Very frequent (99-80%) HP:0002216
11 poliosis 59 32 hallmark (90%) Very frequent (99-80%) HP:0002290
12 short stature 59 32 frequent (33%) Frequent (79-30%) HP:0004322
13 cognitive impairment 59 32 hallmark (90%) Very frequent (99-80%) HP:0100543
14 abnormality of the eyebrow 59 Very frequent (99-80%)
15 abnormal eyebrow morphology 32 hallmark (90%) HP:0000534

GenomeRNAi Phenotypes related to Vogt-Koyanagi-Harada Disease according to GeneCards Suite gene sharing:

26 (show all 30)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 10.27 HLA-B HLA-A
2 Increased shRNA abundance (Z-score > 2) GR00366-A-110 10.27 HLA-DQA1 HLA-A HLA-B
3 Increased shRNA abundance (Z-score > 2) GR00366-A-115 10.27 IL2RA
4 Increased shRNA abundance (Z-score > 2) GR00366-A-118 10.27 HLA-B HLA-A
5 Increased shRNA abundance (Z-score > 2) GR00366-A-121 10.27 HLA-DQA1 IL2RA
6 Increased shRNA abundance (Z-score > 2) GR00366-A-130 10.27 IL2RA
7 Increased shRNA abundance (Z-score > 2) GR00366-A-138 10.27 IL2RA
8 Increased shRNA abundance (Z-score > 2) GR00366-A-149 10.27 HLA-DQA1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-156 10.27 HLA-A HLA-B
10 Increased shRNA abundance (Z-score > 2) GR00366-A-169 10.27 IL2RA
11 Increased shRNA abundance (Z-score > 2) GR00366-A-174 10.27 IL2RA
12 Increased shRNA abundance (Z-score > 2) GR00366-A-178 10.27 HLA-B HLA-A
13 Increased shRNA abundance (Z-score > 2) GR00366-A-185 10.27 IL2RA
14 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.27 HLA-B HLA-DQA1 HLA-A IL2RA
15 Increased shRNA abundance (Z-score > 2) GR00366-A-2 10.27 IL2RA
16 Increased shRNA abundance (Z-score > 2) GR00366-A-202 10.27 IL2RA
17 Increased shRNA abundance (Z-score > 2) GR00366-A-25 10.27 IL2RA
18 Increased shRNA abundance (Z-score > 2) GR00366-A-31 10.27 HLA-B HLA-A
19 Increased shRNA abundance (Z-score > 2) GR00366-A-45 10.27 HLA-DQA1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-46 10.27 IL2RA
21 Increased shRNA abundance (Z-score > 2) GR00366-A-50 10.27 IL2RA
22 Increased shRNA abundance (Z-score > 2) GR00366-A-52 10.27 IL2RA
23 Increased shRNA abundance (Z-score > 2) GR00366-A-67 10.27 IL2RA
24 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.27 HLA-B HLA-A
25 Increased shRNA abundance (Z-score > 2) GR00366-A-73 10.27 HLA-DQA1
26 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.27 HLA-B HLA-A
27 Increased shRNA abundance (Z-score > 2) GR00366-A-9 10.27 IL2RA
28 Increased shRNA abundance (Z-score > 2) GR00366-A-99 10.27 HLA-DQA1
29 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.77 FAS HLA-DQB1 IL10 IL17A IL2RA NLRP1
30 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.77 IL2RA FAS HLA-DQB1 IL10 IL17A NLRP1

MGI Mouse Phenotypes related to Vogt-Koyanagi-Harada Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.03 IL17A TYRP1 IL2RA NLRP1 FAS PMEL
2 endocrine/exocrine gland MP:0005379 9.97 IL10 TYR IL17A IL2RA FAS PTPN22
3 homeostasis/metabolism MP:0005376 9.9 TLR3 IL10 TYR TYRP1 IL17A IL2RA
4 immune system MP:0005387 9.7 TYR IL17A IL2RA NLRP1 FAS PTPN22
5 respiratory system MP:0005388 9.17 IL10 IL17A IL2RA FAS PTPN22 HLA-DQB1

Drugs & Therapeutics for Vogt-Koyanagi-Harada Disease

Drugs for Vogt-Koyanagi-Harada Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 3,Not Applicable 216974-75-3
2 Angiogenesis Inhibitors Phase 3,Not Applicable
3 Angiogenesis Modulating Agents Phase 3,Not Applicable
4
Azathioprine Approved Not Applicable 446-86-6 2265
5
Iodine Approved, Investigational Not Applicable 7553-56-2 807
6
Miconazole Approved, Investigational, Vet_approved Not Applicable 22916-47-8 4189
7
Mycophenolate mofetil Approved, Investigational Not Applicable 128794-94-5 5281078
8
Mycophenolic acid Approved Not Applicable 24280-93-1 446541
9
Povidone Approved Not Applicable 9003-39-8
10
Povidone-iodine Approved Not Applicable 25655-41-8
11
Adalimumab Approved 331731-18-1 16219006
12
Etanercept Approved, Investigational 185243-69-0
13
Infliximab Approved 170277-31-3
14
Methotrexate Approved 1959-05-2, 59-05-2 126941
15
Methylprednisolone Approved, Vet_approved 83-43-2 6741
16
Prednisolone Approved, Vet_approved 50-24-8 5755
17
rituximab Approved 174722-31-7 10201696
18 Anti-Bacterial Agents Not Applicable
19 Antibiotics, Antitubercular Not Applicable
20 Antifungal Agents Not Applicable
21 Anti-Infective Agents Not Applicable
22 Antirheumatic Agents Not Applicable
23 cadexomer iodine Not Applicable
24 Calcineurin Inhibitors Not Applicable
25 Cyclosporins Not Applicable
26 Dermatologic Agents Not Applicable
27 Immunosuppressive Agents Not Applicable
28 Antimetabolites
29 Antimetabolites, Antineoplastic
30 Antitubercular Agents
31 Methylprednisolone acetate
32 Methylprednisolone Hemisuccinate
33 Prednisolone acetate
34 Prednisolone hemisuccinate
35 Prednisolone phosphate

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Intravitreal Bevacizumab for Inflammatory Neovascular Membranes Completed NCT00407121 Phase 3 Bevacizumab
2 Intravitreal Bevacizumab for the Treatment of CNV in VKH Disease - A Prospective Study Unknown status NCT02015351 Not Applicable bevacizumab
3 Causes of Visual Loss in Retinal Disease Unknown status NCT01613963 Immunosuppressive Agents
4 Early Immunosuppressive Therapy on the Course of Vogt-Koyanagi-Harada Disease Recruiting NCT03399175 Not Applicable Early high-dose corticosteroid and immunosuppressive therapy

Search NIH Clinical Center for Vogt-Koyanagi-Harada Disease

Cochrane evidence based reviews: uveomeningoencephalitic syndrome

Genetic Tests for Vogt-Koyanagi-Harada Disease

Anatomical Context for Vogt-Koyanagi-Harada Disease

MalaCards organs/tissues related to Vogt-Koyanagi-Harada Disease:

41
Eye, Skin, Retina, T Cells, Myeloid, Liver, Spinal Cord

Publications for Vogt-Koyanagi-Harada Disease

Articles related to Vogt-Koyanagi-Harada Disease:

(show top 50) (show all 406)
# Title Authors Year
1
Association of Long Noncoding RNAs Polymorphisms With Ankylosing Spondylitis, Vogt-Koyanagi-Harada Disease, and Behcet's Disease. ( 29490353 )
2018
2
Clinical features and visual outcomes of 111 patients with new-onset acute Vogt-Koyanagi-Harada disease treated with pulse intravenous corticosteroids. ( 29666121 )
2018
3
Novel treatment regimen of Vogt-Koyanagi-Harada disease with a reduced dose of corticosteroids combined with immunosuppressive agents. ( 29111815 )
2018
4
Retinal Pigment Epithelium Detachment in Acute Vogt-Koyanagi-Harada Disease: An Unusual Finding at Presentation. ( 29513616 )
2018
5
Recovery of macular cone photoreceptors in Vogt-Koyanagi-Harada disease. ( 29264653 )
2018
6
Vogt-Koyanagi-Harada disease: study of 14 cases. ( 29731134 )
2018
7
Development and Evaluation of Diagnostic Criteria for Vogt-Koyanagi-Harada Disease. ( 29978190 )
2018
8
Changes in Central Macular Thickness and Retinal Nerve Fiber Layer Thickness in Eyes with Vogt-Koyanagi-Harada Disease: A 2-Year Follow-Up Study. ( 29339644 )
2018
9
Association of human leukocyte antigen (HLA)-DQ and HLA-DQA1/DQB1 alleles with Vogt-Koyanagi-Harada disease: A systematic review and meta-analysis. ( 29443768 )
2018
10
Longitudinal observation of subretinal fibrosis in Vogt-Koyanagi-Harada disease. ( 29334924 )
2018
11
Vogt-Koyanagi-Harada Disease Presenting as Unilateral Neuroretinits. ( 29467803 )
2018
12
Diagnostic Function of 3D Optical Coherence Tomography Images in Diagnosis of Vogt-Koyanagi-Harada Disease at Acute Uveitis Stage. ( 29396390 )
2018
13
HLA-DRB1*04:05 in two cases of Vogt-Koyanagi-Harada disease-like uveitis developing from an advanced melanoma patient treated by sequential administration of nivolumab and dabrafenib/trametinib therapy. ( 29488243 )
2018
14
Acquired myopia in Vogt-Koyanagi-Harada disease. ( 29397539 )
2018
15
Vogt-Koyanagi-Harada disease-like uveitis induced by vemurafenib for metastatic cutaneous malignant melanoma. ( 29314171 )
2018
16
Vogt-Koyanagi-Harada Disease Associated with Influenza A Virus Infection: A Case Report. ( 29321438 )
2018
17
MR findings of the orbit in patients with Vogt-Koyanagi-Harada disease. ( 29476208 )
2018
18
Vogt-Koyanagi-Harada disease like presentation in patients with chronic myeloid leukemia. ( 29780937 )
2018
19
Vogt-Koyanagi-Harada Disease Associated with Hepatitis B Vaccination. ( 29953303 )
2018
20
Improving the Diagnostic Criteria for Vogt-Koyanagi-Harada Disease. ( 29978179 )
2018
21
Rare association between Vogt-Koyanagi-Harada disease and rheumatoid arthritis: Report of a clinical case from the unit of multidisciplinary uveitis. ( 29519769 )
2018
22
MicroRNA-20a-5p suppresses IL-17 production by targeting OSM and CCL1 in patients with Vogt-Koyanagi-Harada disease. ( 28972028 )
2018
23
Unusual Case of Vogt-Koyanagi-Harada Disease Associated with SAPHO Syndrome: A Case Report. ( 29681837 )
2018
24
Longitudinal Study of Visual Function in Vogt-Koyanagi-Harada Disease Using Full-Field Electroretinography. ( 29702075 )
2018
25
Polarization-Sensitive Optical Coherence Tomographic Documentation of Choroidal Melanin Loss in Chronic Vogt-Koyanagi-Harada Disease. ( 28863408 )
2017
26
Promoter Hypermethylation of GATA3, IL-4, and TGF-I^ Confers Susceptibility to Vogt-Koyanagi-Harada Disease in Han Chinese. ( 28278322 )
2017
27
Vogt-Koyanagi-Harada disease in a patient of chronic myeloid leukemia. ( 28574001 )
2017
28
Increased Complement 3a Receptor is Associated with Behcet's disease and Vogt-Koyanagi-Harada disease. ( 29138505 )
2017
29
Bilateral Iris Depigmentation and Ocular Hypotony as End-Stage Manifestations of Untreated Vogt-Koyanagi-Harada Disease. ( 28548582 )
2017
30
Expression and role of interleukin-9 in Vogt-Koyanagi-Harada disease. ( 28761327 )
2017
31
Evaluation of Vestibular Functions in Patients with Vogt-Koyanagi-Harada Disease. ( 29080887 )
2017
32
Vogt-Koyanagi-Harada disease-like posterior uveitis in the course of nivolumab (anti-PD-1 antibody), interposed by vemurafenib (BRAF inhibitor), for metastatic cutaneous malignant melanoma. ( 28469878 )
2017
33
Clinical spectrum and management options in Vogt-Koyanagi-Harada disease. ( 28848322 )
2017
34
Optical Coherence Tomography Angiography: Employing a Novel Technique for Investigation in Vogt-Koyanagi-Harada Disease. ( 28868031 )
2017
35
Unilateral Ocular Manifestations of Vogt-Koyanagi-Harada Disease. ( 29020488 )
2017
36
Photoreceptor Cell Injury Starts in the Initial Stage of Vogt-Koyanagi-Harada Disease. ( 28323511 )
2017
37
Corticotherapy vs. Corticotherapy Plus Immunosuppressive Therapy in Acute Vogt-Koyanagi-Harada Disease. ( 29258782 )
2017
38
The spectrum of Vogt-Koyanagi-Harada disease in Iran. ( 28260142 )
2017
39
Optical coherence tomography angiography in incomplete acute Vogt-Koyanagi-Harada disease. ( 28503445 )
2017
40
The effect on choroidal changes of the route of systemic corticosteroids in acute Vogt-Koyanagi-Harada disease. ( 28382438 )
2017
41
Distinguishing features of acute Vogt-Koyanagi-Harada disease and acute central serous chorioretinopathy on optical coherence tomography angiography and en face optical coherence tomography imaging. ( 28091938 )
2017
42
Wide-field fluorescein and indocyanine green angiography findings in the eyes with Vogt-Koyanagi-Harada disease. ( 28695542 )
2017
43
Management of a rare presentation of Vogt-Koyanagi-Harada disease in human immunodeficiency virus/acquired immunodeficiency disease syndrome patient. ( 28574002 )
2017
44
Differences in photoreceptor recovery among patients and between different parts of the posterior pole in Vogt-Koyanagi-Harada disease. ( 29148525 )
2017
45
Choroidal and Retinal Anatomical Responses Following Systemic Corticosteroid Therapy in Vogt-Koyanagi-Harada Disease Using Swept-Source Optical Coherence Tomography. ( 28700251 )
2017
46
Hypermethylation of Interferon Regulatory Factor 8 (IRF8) Confers Risk to Vogt-Koyanagi-Harada Disease. ( 28432342 )
2017
47
A case of Vogt Koyanagi Harada disease in a 16 year old girl. ( 29171577 )
2017
48
Evaluation of the Glucocorticoid Receptor as a Biomarker of Treatment Response in Vogt-Koyanagi-Harada Disease. ( 28535268 )
2017
49
Induction of Vogt-Koyanagi-Harada Disease by Interferon-Alpha and Ribavirin Treatment in Patients with Hepatitis C: A Case Report and Review of the Literature. ( 29023176 )
2017
50
The Choroidal Vascularity Index Decreases and Choroidal Thickness Increases in Vogt-Koyanagi-Harada Disease Patients During a Recurrent Anterior Uveitis Attack. ( 28914578 )
2017

Variations for Vogt-Koyanagi-Harada Disease

Expression for Vogt-Koyanagi-Harada Disease

Search GEO for disease gene expression data for Vogt-Koyanagi-Harada Disease.

Pathways for Vogt-Koyanagi-Harada Disease

Pathways related to Vogt-Koyanagi-Harada Disease according to GeneCards Suite gene sharing:

(show all 30)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.93 HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10
2
Show member pathways
13.24 HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10
3
Show member pathways
13.19 FAS IL10 IL17A IL2RA PTPN22 TGFBR3
4
Show member pathways
12.87 FAS HLA-A HLA-B IL2RA TLR3
5
Show member pathways
12.85 HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
6
Show member pathways
12.55 HLA-A HLA-B IL10 IL17A IL2RA
7
Show member pathways
12.46 FAS HLA-A HLA-B TLR3
8
Show member pathways
12.46 HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
9
Show member pathways
12.29 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL2RA
10
Show member pathways
12.27 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10 IL17A IL2RA
11
Show member pathways
12.25 HLA-DQA1 HLA-DQB1 HLA-DRB1 PTPN22
12
Show member pathways
12.25 FAS HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
13 12.21 HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1 IL2RA
14 12.21 FAS IL10 IL17A IL2RA NLRP1 PTPN22
15
Show member pathways
12.16 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10
16 12.14 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10
17
Show member pathways
12.08 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL2RA
18 12.04 HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10
19
Show member pathways
12.02 FAS HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
20 12.01 HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
21 11.96 HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
22
Show member pathways
11.87 HLA-DQA1 HLA-DQB1 HLA-DRB1 PTPN22
23
Show member pathways
11.86 HLA-A HLA-DRB1 IL2RA
24 11.82 HLA-DQA1 HLA-DQB1 HLA-DRB1
25 11.8 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL2RA
26 11.75 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL17A
27 11.7 IL10 IL17A IL2RA
28 11.63 HLA-DQA1 HLA-DQB1 HLA-DRB1 PTPN22
29 11.51 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL10
30 10.27 TYR TYRP1

GO Terms for Vogt-Koyanagi-Harada Disease

Cellular components related to Vogt-Koyanagi-Harada Disease according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 Golgi membrane GO:0000139 9.88 HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1 TLR3
2 lysosomal membrane GO:0005765 9.87 HLA-DQA1 HLA-DQB1 HLA-DRB1 TLR3
3 external side of plasma membrane GO:0009897 9.85 HLA-DRB1 IL17A IL2RA TGFBR3
4 cell surface GO:0009986 9.8 FAS HLA-A HLA-B HLA-DRB1 IL2RA TGFBR3
5 endosome membrane GO:0010008 9.77 HLA-DQA1 HLA-DQB1 HLA-DRB1 TLR3 TYRP1
6 melanosome GO:0042470 9.73 PMEL TYR TYRP1
7 trans-Golgi network membrane GO:0032588 9.67 HLA-DQA1 HLA-DQB1 HLA-DRB1
8 endocytic vesicle membrane GO:0030666 9.63 HLA-DQA1 HLA-DQB1 HLA-DRB1
9 transport vesicle membrane GO:0030658 9.61 HLA-DQA1 HLA-DQB1 HLA-DRB1
10 melanosome membrane GO:0033162 9.52 TYR TYRP1
11 MHC class II protein complex GO:0042613 9.5 HLA-DQA1 HLA-DQB1 HLA-DRB1
12 MHC class I protein complex GO:0042612 9.48 HLA-A HLA-B
13 clathrin-coated endocytic vesicle membrane GO:0030669 9.46 HLA-DQA1 HLA-DQB1 HLA-DRB1 TYRP1
14 ER to Golgi transport vesicle membrane GO:0012507 9.35 HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
15 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.02 HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
16 integral component of membrane GO:0016021 10.31 FAS HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
17 integral component of plasma membrane GO:0005887 10.05 FAS HLA-A HLA-B HLA-DQA1 PMEL TGFBR3

Biological processes related to Vogt-Koyanagi-Harada Disease according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.88 FAS IL10 IL17A IL2RA NLRP1 TLR3
2 immune system process GO:0002376 9.86 HLA-A HLA-B HLA-DQA1 HLA-DRB1 IL2RA NLRP1
3 T cell receptor signaling pathway GO:0050852 9.78 HLA-DQA1 HLA-DQB1 HLA-DRB1 PTPN22
4 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.73 HLA-DQA1 HLA-DQB1 HLA-DRB1
5 T cell costimulation GO:0031295 9.72 HLA-DQA1 HLA-DQB1 HLA-DRB1
6 negative regulation of T cell proliferation GO:0042130 9.63 HLA-DRB1 IL10 IL2RA
7 melanosome organization GO:0032438 9.58 PMEL TYRP1
8 inflammatory response to antigenic stimulus GO:0002437 9.57 HLA-DRB1 IL2RA
9 interferon-gamma-mediated signaling pathway GO:0060333 9.55 HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
10 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.54 HLA-A HLA-B
11 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.54 HLA-DQA1 HLA-DQB1 HLA-DRB1
12 necroptotic signaling pathway GO:0097527 9.52 FAS TLR3
13 protection from natural killer cell mediated cytotoxicity GO:0042270 9.51 HLA-A HLA-B
14 melanin biosynthetic process GO:0042438 9.5 PMEL TYR TYRP1
15 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.49 HLA-DQB1 HLA-DRB1
16 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.43 HLA-DQB1 HLA-DRB1
17 antigen processing and presentation GO:0019882 9.35 HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
18 immune response GO:0006955 9.32 FAS HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1

Molecular functions related to Vogt-Koyanagi-Harada Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MHC class II receptor activity GO:0032395 9.13 HLA-DQA1 HLA-DQB1 HLA-DRB1
2 peptide antigen binding GO:0042605 9.02 HLA-A HLA-B HLA-DQA1 HLA-DQB1 HLA-DRB1
3 protein binding GO:0005515 10.09 ARMC9 FAS HLA-A HLA-B HLA-DQA1 HLA-DQB1

Sources for Vogt-Koyanagi-Harada Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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