Aliases & Classifications for Volkmann Contracture

MalaCards integrated aliases for Volkmann Contracture:

Name: Volkmann Contracture 12 15 71
Ischemic Contracture 43 71
Volkmann's Ischemic Contracture 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5587
ICD9CM 34 958.6
MeSH 43 D054061
NCIt 49 C35130
ICD10 32 T79.6
UMLS 71 C0042951 C0334142

Summaries for Volkmann Contracture

Disease Ontology : 12 A connective tissue disease that develops from prolonged ischemia and results in permanent necrosis, stiffening, and shortening of affected muscles.

MalaCards based summary : Volkmann Contracture, also known as ischemic contracture, is related to compartment syndrome and sulfonamide allergy. An important gene associated with Volkmann Contracture is CCDC8 (Coiled-Coil Domain Containing 8), and among its related pathways/superpathways are Apoptosis and Autophagy and Formation of Fibrin Clot (Clotting Cascade). The drug Anesthetics has been mentioned in the context of this disorder. Affiliated tissues include heart, bone and thyroid, and related phenotype is mortality/aging.

Related Diseases for Volkmann Contracture

Diseases related to Volkmann Contracture via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 161)
# Related Disease Score Top Affiliating Genes
1 compartment syndrome 30.1 SERPINC1 F3 F2 EVC2
2 sulfonamide allergy 10.4 CA6 CA5A
3 acquired color blindness 10.3 F3 CD2AP
4 aplasia cutis congenita, nonsyndromic 10.2
5 leukemia, chronic myeloid 10.2
6 ischemic neuropathy 10.2
7 gas gangrene 10.2
8 hemophilia 10.2
9 lymphedema 10.2
10 osteomyelitis 10.2
11 malt worker's lung 10.2 SERPINC1 CD2AP
12 vulvar angiokeratoma 10.2 SERPINC1 F3
13 astrakhan spotted fever 10.2 F3 CD40LG
14 vulvar benign neoplasm 10.2 SERPINC1 CD2AP
15 catastrophic antiphospholipid syndrome 10.2 F3 CD40LG
16 leech infestation 10.1 SERPINC1 F3
17 gastric hemangioma 10.1 F3 F2
18 thrombophlebitis migrans 10.1 SERPINC1 F3
19 synovial angioma 10.1 F3 F2
20 rocky mountain spotted fever 10.1 F3 CD40LG
21 emphysematous cholecystitis 10.1 F3 F2
22 carotid artery thrombosis 10.1 SERPINC1 F3
23 femoral neuropathy 10.1 F3 F2
24 lemierre's syndrome 10.1 F3 F2
25 syphilitic meningitis 10.1 SERPINC1 CD40LG
26 qualitative platelet defect 10.1 F3 F2
27 ebola hemorrhagic fever 10.1 F3 CD40LG
28 cerebral sinovenous thrombosis 10.1 F3 F2
29 hemopericardium 10.1 F3 F2
30 intracranial hypotension 10.0 F3 F2
31 hantavirus hemorrhagic fever with renal syndrome 10.0 F3 CD40LG
32 active peptic ulcer disease 10.0 F3 F2
33 analbuminemia 10.0 F3 F2
34 intracranial hypertension, idiopathic 10.0 F3 F2
35 spinal cord infarction 10.0 SERPINC1 F2
36 hemarthrosis 10.0 F3 F2
37 von willebrand disease, type 1 10.0 F3 F2
38 ocular motor apraxia 10.0
39 sudden sensorineural hearing loss 10.0 SERPINC1 F2
40 thrombasthenia 10.0 F3 F2
41 lateral sinus thrombosis 10.0 SERPINC1 F2
42 factor xii deficiency 10.0 SERPINC1 F3
43 cardiac tamponade 10.0 F3 F2
44 waterhouse-friderichsen syndrome 10.0 SERPINC1 F2
45 cavernous sinus thrombosis 10.0 SERPINC1 F2
46 thoracic outlet syndrome 10.0 SERPINC1 F2
47 splenic abscess 10.0 F2 CD40LG
48 factor x deficiency 10.0 F3 F2
49 prothrombin deficiency, congenital 10.0 SERPINC1 F2
50 tricuspid valve insufficiency 9.9 F3 F2

Graphical network of the top 20 diseases related to Volkmann Contracture:



Diseases related to Volkmann Contracture

Symptoms & Phenotypes for Volkmann Contracture

MGI Mouse Phenotypes related to Volkmann Contracture:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.32 CA5A CCDC8 CD2AP CD40LG EVC2 F2

Drugs & Therapeutics for Volkmann Contracture

Drugs for Volkmann Contracture (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anesthetics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Remote Ischemic Preconditioning of Human Myocardium Completed NCT01994707 Phase 2
2 Near Infrared Spectroscopy for the Evaluation of Pediatric Forearm Compartment Perfusion After Supracondylar Humerus Fracture Completed NCT01808183

Search NIH Clinical Center for Volkmann Contracture

Cochrane evidence based reviews: ischemic contracture

Genetic Tests for Volkmann Contracture

Anatomical Context for Volkmann Contracture

MalaCards organs/tissues related to Volkmann Contracture:

40
Heart, Bone, Thyroid, Skin, Skeletal Muscle, Neutrophil, Spinal Cord

Publications for Volkmann Contracture

Articles related to Volkmann Contracture:

(show top 50) (show all 475)
# Title Authors PMID Year
1
Changes in the Stoichiometry of Uniplex Decrease Mitochondrial Calcium Overload and Contribute to Tolerance of Cardiac Ischemia/Reperfusion Injury in Hypothyroidism. 61
31456501 2019
2
Perfused murine heart optical transmission spectroscopy using optical catheter and integrating sphere: Effects of ischemia/reperfusion. 61
31539522 2019
3
Reconstruction of a Chronic Volkmann Contracture following Forearm Revascularization with Burkhalter's Procedure and Fractional Flexor Tendon Lengthening after a Failed Stiles-Bunnell Transfer. 61
31616125 2019
4
Effect of pralidoxime on coronary perfusion pressure during cardiopulmonary resuscitation in a pig model. 61
31036784 2019
5
A new approach for surgical treatment of chronic Monteggia fracture in children. 61
31056214 2019
6
Functional and socioprofessional outcome of surgery for Volkmann's contracture. 61
30470521 2019
7
Exploration of the optimal dose of HOE-642 for the protection of neuronal mitochondrial function after cardiac arrest in rats. 61
30554120 2019
8
Pseudo-Volkmann Contracture: A Case Report and Review of the Current Literature. 61
30656257 2018
9
Predictive factors determining outcomes in pulseless limb in paediatric supracondylar fractures of humerus. 61
29628707 2018
10
Consecutive Isoproterenol and Adenosine Treatment Confers Marked Protection against Reperfusion Injury in Adult but Not in Immature Heart: A Role for Glycogen. 61
29414860 2018
11
Posterior Elbow Dislocation with Brachial Artery Thrombosis Treated Non-surgically: A Case Report. 61
29326772 2017
12
The Community Orthopaedic Surgeon Taking Trauma Call: Pediatric Tibia Fracture Pearls and Pitfalls. 61
29053501 2017
13
Angiosome-Based Allografts: Vascularized Composite Allotransplantation for Tailored Subunit Reconstruction with Volkmann Ischemic Contracture as a Case in Point. 61
28538571 2017
14
Endoscopic Adhesiolysis of Flexor Hallucis Longus Muscle. 61
28580249 2017
15
Volkmann's ischemic contracture: An unusual complication of arterio-venous fistula. 61
27329788 2017
16
Results of neurolysis in established upper limb Volkmann's ischemic contracture. 61
27904214 2016
17
2,3-Butanedione monoxime facilitates successful resuscitation in a dose-dependent fashion in a pig model of cardiac arrest. 61
27041248 2016
18
Biomechanical Study of the Digital Flexor Tendon Sliding Lengthening Technique. 61
26304736 2015
19
Spontaneous Compartment Syndrome of the Hand in Systemic Sclerosis. 61
26375546 2015
20
[Compartment syndrome and Volkmann contracture]. 61
26495537 2015
21
[Treatment of humeral supracondylar fracture in children with external plaster fixation on extension position]. 61
26502528 2015
22
Depressed calcium cycling contributes to lower ischemia tolerance in hearts of estrogen-deficient rats. 61
25513985 2015
23
[Manipulative reduction and percutaneous K-wires fixation for treatment of supracondylar fractures of the humerus in children]. 61
26255476 2015
24
[Emergency closed reduction and percutaneous Kirschner wire fixation for treatment of Gartland type II-III supracondylar fractures of the humerus in children]. 61
26193729 2015
25
Flexor digitorum brevis tendon transfer to the flexor digitorum longus tendon according to Valtin in posttraumatic flexible claw toe deformity due to extrinsic toe flexor shortening. 61
25703152 2015
26
Expression of SGLT1 in Human Hearts and Impairment of Cardiac Glucose Uptake by Phlorizin during Ischemia-Reperfusion Injury in Mice. 61
26121582 2015
27
Volkmann's Ischemic Contracture with Atrophic Non-union of Ulna Managed by Bone Shortening and Transposition of Radial Autograft. 61
27299025 2015
28
Neonatal volkmann ischemic contracture: case report and review of literature. 61
25452886 2014
29
The functional free innervated medial gastrocnemius flap. 61
24838386 2014
30
Congenital Volkmann syndrome and aplasia cutis of the forearm: a challenging differential diagnosis. 61
24965679 2014
31
Functional free muscle transfer for upper extremity reconstruction. 61
24732655 2014
32
[Transtibial amputation of the lower extremity in patients with ischemic foot contracture]. 61
25252412 2014
33
[Free re-innervated Latissimus Dorsi musculocutaneous flap for treat congenital Volkmann ischemic Contracture: a case report]. 61
24793235 2014
34
Aromatase transgenic upregulation modulates basal cardiac performance and the response to ischemic stress in male mice. 61
24610919 2014
35
The outcomes of salvage surgery for vascular injury in the extremities: a special consideration for delayed revascularization. 61
25279079 2014
36
Free function muscle transfers for upper extremity reconstruction: a review of indications, techniques, and outcomes. 61
24210720 2013
37
Photochemically altered air pollution mixtures and contractile parameters in isolated murine hearts before and after ischemia. 61
24148996 2013
38
[Functional diagnosis of the foot ischemic contracture]. 61
24501996 2013
39
Cardiovascular protection and antioxidant activity of the extracts from the mycelia of Cordyceps sinensis act partially via adenosine receptors. 61
23192916 2013
40
Angiotensin II type 2 receptor (AT2R) is associated with increased tolerance of the hyperthyroid heart to ischemia-reperfusion. 61
23807455 2013
41
Is closed manipulative reduction and percutaneous Kirschner wiring of supracondylar humeral fracture in children as day-care surgery a safe procedure ? 61
25722817 2013
42
A practical correction of great toe claw deformity. 61
23602717 2013
43
Myocardial protection against global ischemia with Krebs-Henseleit buffer-based cardioplegic solution. 61
23547937 2013
44
Flexor origin slide for contracture of spastic finger flexor muscles: a retrospective study. 61
23467868 2013
45
[Diagnostics and correction of vascular disorders in upper extremity muscular transplants]. 61
23887262 2013
46
Supernumerary flexor carpi ulnaris--case report and review. 61
24156584 2013
47
Results of the Max Page muscle sliding operation for the treatment of Volkmann's ischemic contracture of the forearm. 61
23053046 2012
48
[Closed treatment for type III humeral supracondylar fractures and prevention of ischemic contracture of forearm in children]. 61
23256373 2012
49
Ca2+/calmodulin-dependent protein kinase inhibition suppresses post-ischemic arrhythmogenesis and mediates sinus bradycardic recovery in reperfusion. 61
21392835 2012
50
Clinical review: Volkmann's ischaemic contracture. 61
26815829 2012

Variations for Volkmann Contracture

Expression for Volkmann Contracture

Search GEO for disease gene expression data for Volkmann Contracture.

Pathways for Volkmann Contracture

Pathways related to Volkmann Contracture according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.7 PIM1 LMNA CD40LG
2
Show member pathways
11.33 SERPINC1 F3 F2
3 10.96 SERPINC1 F3 F2
4
Show member pathways
10.62 CA6 CA5A

GO Terms for Volkmann Contracture

Biological processes related to Volkmann Contracture according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein localization to nucleus GO:1900182 9.16 F2 CD2AP
2 regulation of blood coagulation GO:0030193 8.96 SERPINC1 F2
3 hemostasis GO:0007599 8.8 SERPINC1 F3 F2

Molecular functions related to Volkmann Contracture according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 carbonate dehydratase activity GO:0004089 8.62 CA6 CA5A

Sources for Volkmann Contracture

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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