MCID: VLV031
MIFTS: 36

Vulva Adenocarcinoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Vulva Adenocarcinoma

MalaCards integrated aliases for Vulva Adenocarcinoma:

Name: Vulva Adenocarcinoma 12 15
Adenocarcinoma of the Vulva 12
Adenocarcinoma of Vulva 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2098
NCIt 51 C6380
UMLS 74 C1336975

Summaries for Vulva Adenocarcinoma

Disease Ontology : 12 A vulva carcinoma that derives from epithelial cells of glandular origin.

MalaCards based summary : Vulva Adenocarcinoma, also known as adenocarcinoma of the vulva, is related to appendix adenocarcinoma and mucinous adenocarcinoma. An important gene associated with Vulva Adenocarcinoma is KRT7 (Keratin 7), and among its related pathways/superpathways are Gastric cancer and DNA Damage Response (only ATM dependent). The drugs Durvalumab and Ipilimumab have been mentioned in the context of this disorder. Affiliated tissues include ovary, appendix and kidney, and related phenotype is cellular.

Related Diseases for Vulva Adenocarcinoma

Diseases related to Vulva Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 254)
# Related Disease Score Top Affiliating Genes
1 appendix adenocarcinoma 30.6 CDX2 KRT20 KRT7
2 mucinous adenocarcinoma 30.3 CDKN2A CDX2 KRT20 KRT7
3 mammary paget's disease 30.3 ERBB2 KRT20 KRT7
4 eccrine adenocarcinoma 29.7 CEACAM5 KRT7 PIP
5 adenoid cystic carcinoma 29.6 ERBB2 KRT20 KRT7 TP53
6 vulval paget's disease 29.6 CD86 CDKN2A CEACAM5 ERBB2 KRT20 KRT7
7 vulvar adenocarcinoma 11.7
8 vulvar eccrine adenocarcinoma 11.2
9 vulvar apocrine adenocarcinoma 11.2
10 immune system organ benign neoplasm 10.5 KRT20 KRT7
11 bladder lymphoma 10.5 KRT20 KRT7
12 seminal vesicle adenocarcinoma 10.5 KRT20 KRT7
13 thymus lipoma 10.5 KRT20 KRT7
14 transverse colon cancer 10.5 KRT20 KRT7
15 dermoid cyst 10.5 KRT20 KRT7
16 mucinous cystadenocarcinoma 10.5 KRT20 KRT7
17 urethral diverticulum 10.5 KRT7 UPK3A
18 papillary transitional carcinoma 10.5 KRT20 KRT7
19 linitis plastica 10.5 KRT20 KRT7
20 medulloepithelioma 10.5 KRT20 KRT7
21 ovarian cystic teratoma 10.5 KRT20 KRT7
22 cystadenofibroma 10.5 KRT20 KRT7
23 adenoid squamous cell carcinoma 10.5 KRT20 KRT7
24 lymphoepithelioma-like carcinoma 10.5 KRT20 KRT7
25 malignant syringoma 10.5 KRT20 KRT7
26 eyelid carcinoma 10.5 KRT20 KRT7
27 lung acinar adenocarcinoma 10.5 KRT20 KRT7
28 intratubular embryonal carcinoma 10.5 KRT20 KRT7
29 krukenberg carcinoma 10.5 KRT20 KRT7
30 small cell carcinoma of the bladder 10.5 KRT20 KRT7
31 breast secretory carcinoma 10.5 ERBB2 KRT7
32 anal canal carcinoma 10.4 CDKN2A KRT7
33 nasal cavity squamous cell carcinoma 10.4 CDKN2A KRT7
34 cervical adenosquamous carcinoma 10.4 CDKN2A KRT7
35 endocervical carcinoma 10.4 CDKN2A KRT7
36 duodenum adenocarcinoma 10.4 CDX2 KRT7
37 well-differentiated liposarcoma 10.4 CDKN2A KRT7
38 anal canal adenocarcinoma 10.4 CDX2 KRT7
39 epithelial predominant wilms' tumor 10.4 CDX2 KRT7
40 fallopian tube endometrioid adenocarcinoma 10.4 CDKN2A ERBB2
41 ewing's family of tumors 10.4 CDKN2A ERBB2
42 renal pelvis transitional cell carcinoma 10.4 KRT7 UPK3A
43 female reproductive endometrioid cancer 10.4 KRT7 TP53
44 epithelial-myoepithelial carcinoma 10.4 KRT7 TP53
45 pleomorphic carcinoma 10.4 KRT7 TP53
46 vulvar intraepithelial neoplasia 10.4 KRT7 TP53
47 bartholin's gland benign neoplasm 10.4 CD86 CDKN2A
48 non-invasive bladder papillary urothelial neoplasm 10.4 TP53 UPK3A
49 invasive bladder transitional cell carcinoma 10.4 TP53 UPK3A
50 bladder papillary transitional cell neoplasm 10.4 KRT20 TP53

Graphical network of the top 20 diseases related to Vulva Adenocarcinoma:



Diseases related to Vulva Adenocarcinoma

Symptoms & Phenotypes for Vulva Adenocarcinoma

MGI Mouse Phenotypes related to Vulva Adenocarcinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.23 CD86 CDKN2A CDX2 ERBB2 INPP4B KRT7

Drugs & Therapeutics for Vulva Adenocarcinoma

Drugs for Vulva Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Durvalumab Approved, Investigational Phase 1 1428935-60-7
2
Ipilimumab Approved Phase 1 477202-00-9
3
Tremelimumab Investigational Phase 1 745013-59-6
4 Immunologic Factors Phase 1
5 Immunoglobulins Phase 1
6 Antineoplastic Agents, Immunological Phase 1
7 Antibodies Phase 1
8 Antibodies, Monoclonal Phase 1
9 Immunoglobulin G Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Stereotactic Body Radiation Therapy, Tremelimumab and Durvalumab in Treating Participants With Recurrent or Metastatic Cervical, Vaginal, or Vulvar Cancers Recruiting NCT03452332 Phase 1
2 Biospecimen Collection and Testing for the Prevalence of Anal Dysplasia and Anal Cancer in Patients With Cervical, Vaginal and Vulvar Dysplasia and Cancer Recruiting NCT02140021 Not Applicable

Search NIH Clinical Center for Vulva Adenocarcinoma

Genetic Tests for Vulva Adenocarcinoma

Anatomical Context for Vulva Adenocarcinoma

MalaCards organs/tissues related to Vulva Adenocarcinoma:

42
Ovary, Appendix, Kidney, Colon, Testes, Testis, Thymus

Publications for Vulva Adenocarcinoma

Articles related to Vulva Adenocarcinoma:

(show all 27)
# Title Authors Year
1
Primary Clear Cell Adenocarcinoma of the Vulva: A Case Study With Mutation Analysis and Literature Review. ( 31104528 )
2019
2
Intestinal-type adenocarcinoma of the vulva: A case study. ( 31061870 )
2019
3
Cloacogenic Adenocarcinoma of the Vulva: A Case Report and Review of the Literature. ( 28272666 )
2018
4
Primary mucinous adenocarcinoma of the vulva, intestinal type. ( 28791269 )
2017
5
Primary Villoglandular Mucinous Adenocarcinoma of the Vulva. ( 28503335 )
2017
6
Molecular subtyping of mammary-like adenocarcinoma of the vulva shows molecular similarity to breast carcinomas. ( 28418164 )
2017
7
Cloacogenic adenocarcinoma of the vulva: one new case and literature review. ( 29953800 )
2017
8
Apocrine Adenocarcinoma of the Vulva: A Case Report and Review of the Literature. ( 27668109 )
2016
9
Primary mucinous adenocarcinoma of the vulva: A case report and review of the literature. ( 27073659 )
2016
10
Mammary-like adenocarcinoma of the vulva associated to Paget's disease: a case report. ( 25848451 )
2014
11
Apocrine adenocarcinoma of the vulva. ( 24179652 )
2013
12
"Intestinal-type" mucinous adenocarcinoma of the vulva: a report of two cases. ( 23091907 )
2012
13
Anogenital sweat gland adenocarcinoma of the vulva: a diagnostic conundrum. ( 22407069 )
2012
14
Primary adnexal adenocarcinoma of the vulva: A diagnosis of exclusion based on location, immunohistochemistry, and pattern of spread. ( 24371661 )
2012
15
Collision tumor composed of mammary-type myofibroblastoma and eccrine adenocarcinoma of the vulva. ( 21355955 )
2011
16
Primary adenocarcinoma of the vulva with an unusual histological pattern. ( 15205982 )
2004
17
Polymorphous low-grade adenocarcinoma of the vulva and vagina: a tumor resembling adenoid cystic carcinoma. ( 12598921 )
2003
18
Cloacogenic adenocarcinoma of the vulva presenting as recurrent Bartholin's gland infection. ( 12684613 )
2003
19
Villoglandular adenocarcinoma of the vulva. ( 11606106 )
2001
20
Clear cell adenocarcinoma of the vulva arising in endometriosis. A case report. ( 11055499 )
2000
21
Cloacogenic adenocarcinoma of the vulva. ( 10419750 )
1999
22
Primary neuroendocrine differentiated mucinous adenocarcinoma of the vulva: case report and review of the literature. ( 9677464 )
1998
23
Primary adenocarcinoma of the vulva, possibly cloacogenic. A report of two cases. ( 8445601 )
1993
24
Clear cell ("mesonephroid") adenocarcinoma of the vulva arising in endometriosis: a case report. ( 3345958 )
1988
25
Eccrine adenocarcinoma of the vulva producing isolated alpha-subunit of glycoprotein hormones. ( 3511416 )
1986
26
Apocrine adenocarcinoma of the vulva with associated Paget's disease. Diagnosis of lymph node metastases by fine needle aspiration biopsy. ( 6322492 )
1984
27
Primary adenocarcinoma of the vulva originating in misplaced cloacal tissue. ( 618471 )
1978

Variations for Vulva Adenocarcinoma

Expression for Vulva Adenocarcinoma

Search GEO for disease gene expression data for Vulva Adenocarcinoma.

Pathways for Vulva Adenocarcinoma

Pathways related to Vulva Adenocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.22 CDKN2A CDX2 ERBB2 TP53
2 11.39 CDKN2A ERBB2 TP53
3 11 CDKN2A ERBB2 TP53
4 10.79 CDKN2A ERBB2 TP53 UPK3A
5 10.71 CDKN2A TP53
6
Show member pathways
10.66 CDKN2A TP53

GO Terms for Vulva Adenocarcinoma

Biological processes related to Vulva Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.46 CDKN2A ERBB2 PIP TP53
2 replicative senescence GO:0090399 8.96 CDKN2A TP53
3 negative regulation of immature T cell proliferation in thymus GO:0033088 8.62 CDKN2A ERBB2

Sources for Vulva Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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