MCID: VLV034
MIFTS: 33

Vulva Squamous Cell Carcinoma

Categories: Reproductive diseases, Rare diseases, Cancer diseases, Skin diseases

Aliases & Classifications for Vulva Squamous Cell Carcinoma

MalaCards integrated aliases for Vulva Squamous Cell Carcinoma:

Name: Vulva Squamous Cell Carcinoma 12 15
Squamous Cell Carcinoma of Vulva 12 73
Vulvar Squamous Cell Carcinoma 12 59
Squamous Cell Carcinoma of the Vulva 59
Vulvar Epidermoid Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2101
NCIt 50 C4052
SNOMED-CT 68 254895003
Orphanet 59 ORPHA494448
UMLS 73 C0280856

Summaries for Vulva Squamous Cell Carcinoma

Disease Ontology : 12 A vulva carcinoma and has material basis in squamous cells and is located in the epidermis of the vulvar tissue.

MalaCards based summary : Vulva Squamous Cell Carcinoma, also known as squamous cell carcinoma of vulva, is related to squamous cell carcinoma and prostate disease. An important gene associated with Vulva Squamous Cell Carcinoma is MEG3 (Maternally Expressed 3
LncRNAs (MEG3 and MALAT1) were also identified as potential biomarkers as they also correlated with VSCC carcinogenesis.
Dysfunction Pattern: Expression), and among its related pathways/superpathways are Photodynamic therapy-induced AP-1 survival signaling. and Oncogene Induced Senescence. The drugs Cisplatin and Paclitaxel have been mentioned in the context of this disorder. Affiliated tissues include the epidermis of the vulvar tissue, lymph node and skin.

Related Diseases for Vulva Squamous Cell Carcinoma

Diseases related to Vulva Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 89)
# Related Disease Score Top Affiliating Genes
1 squamous cell carcinoma 29.3 CDKN2A MALAT1 SERPINB3 TP53
2 prostate disease 10.8 MALAT1 MEG3
3 malignant glioma 10.7 MALAT1 MEG3
4 brain stem astrocytic neoplasm 10.7 CDKN2A TP53
5 keratinizing squamous cell carcinoma 10.7 CDKN2A TP53
6 spitz nevus 10.7 CDKN2A TP53
7 bladder carcinoma in situ 10.6 CDKN2A TP53
8 bartholin's gland benign neoplasm 10.6 CDKN2A TP53
9 thyroid lymphoma 10.6 CDKN2A TP53
10 nasal cavity adenocarcinoma 10.6 CDKN2A TP53
11 bone squamous cell carcinoma 10.6 CDKN2A TP53
12 pituitary adenoma 10.6 MALAT1 MEG3
13 scrotal carcinoma 10.6 CDKN2A TP53
14 anal squamous cell carcinoma 10.6 CDKN2A TP53
15 glycogen-rich clear cell breast carcinoma 10.6 CDKN2A TP53
16 gastric adenosquamous carcinoma 10.6 CDKN2A TP53
17 oral leukoplakia 10.6 CDKN2A TP53
18 anogenital venereal wart 10.6 CDKN2A TP53
19 megaesophagus 10.6 CDKN2A TP53
20 ovarian epithelial cancer 10.6 MALAT1 MEG3
21 cervix uteri carcinoma in situ 10.6 CDKN2A TP53
22 schneiderian carcinoma 10.6 CDKN2A TP53
23 meningeal melanomatosis 10.6 CDKN2A TP53
24 dedifferentiated liposarcoma 10.6 CDKN2A TP53
25 suppressor of tumorigenicity 3 10.6 CDKN2A TP53
26 embryonal sarcoma 10.6 MALAT1 TP53
27 oropharynx cancer 10.6 CDKN2A TP53
28 endocervical adenocarcinoma 10.6 CDKN2A TP53
29 cervix small cell carcinoma 10.6 CDKN2A TP53
30 necrotizing sialometaplasia 10.6 CDKN2A TP53
31 basaloid squamous cell carcinoma 10.6 CDKN2A TP53
32 biliary tract neoplasm 10.6 CDKN2A TP53
33 optic nerve neoplasm 10.5 CDKN2A TP53
34 recessive dystrophic epidermolysis bullosa 10.5 CDKN2A TP53
35 squamous cell papilloma 10.5 CDKN2A TP53
36 pre-malignant neoplasm 10.5 CDKN2A TP53
37 juvenile pilocytic astrocytoma 10.5 CDKN2A TP53
38 barrett's adenocarcinoma 10.5 CDKN2A TP53
39 cervix carcinoma 10.5 CDKN2A TP53
40 tonsil cancer 10.5 CDKN2A SERPINB3
41 gastrointestinal system benign neoplasm 10.5 CDKN2A TP53
42 skin squamous cell carcinoma 10.5 CDKN2A TP53
43 cellular schwannoma 10.5 CDKN2A TP53
44 penile cancer 10.4 CDKN2A TP53
45 anal canal squamous cell carcinoma 10.4 CDKN2A SERPINB3
46 pancreatic ductal carcinoma 10.4 CDKN2A TP53
47 bladder squamous cell carcinoma 10.4 CDKN2A TP53
48 in situ carcinoma 10.4 CDKN2A TP53
49 central nervous system lymphoma 10.4 CDKN2A TP53
50 anus cancer 10.4 CDKN2A SERPINB3

Graphical network of the top 20 diseases related to Vulva Squamous Cell Carcinoma:



Diseases related to Vulva Squamous Cell Carcinoma

Symptoms & Phenotypes for Vulva Squamous Cell Carcinoma

Drugs & Therapeutics for Vulva Squamous Cell Carcinoma

Drugs for Vulva Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 3,Phase 2,Phase 1 15663-27-1 84093 441203 2767
2
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
3
Gemcitabine Approved Phase 2 95058-81-4 60750
4
nivolumab Approved Phase 2 946414-94-4
5
Erlotinib Hydrochloride Phase 2 183319-69-9 176871
6 Protein Kinase Inhibitors Phase 2
7 Albumin-Bound Paclitaxel Phase 2
8 Antimitotic Agents Phase 2
9 Antineoplastic Agents, Phytogenic Phase 2
10 Antibodies Phase 2
11 Immunoglobulins Phase 2
12 Anti-Infective Agents Phase 2
13 Antimetabolites Phase 2
14 Antimetabolites, Antineoplastic Phase 2
15 Antiviral Agents Phase 2
16 Immunosuppressive Agents Phase 2
17 Antibodies, Monoclonal Phase 2
18
Formaldehyde Approved, Vet_approved 50-00-0 712
19
Dimenhydrinate Approved 523-87-5 441281
20
Ethanol Approved 64-17-5 702
21
Hydrogen peroxide Approved, Vet_approved 7722-84-1 784
22 Pharmaceutical Solutions

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Radiation Therapy or Surgery in Treating Patients With Previously Untreated Vulva Cancer With Positive Groin Lymph Nodes Completed NCT00898352 Phase 3
2 Lymphatic Mapping in Treating Patients With Stage I or Stage II Cancer of the Vulva Completed NCT00003325 Phase 3
3 Radiation Therapy With or Without Cisplatin in Treating Patients With Stage I, Stage II, or Stage III Cancer of the Vulva Terminated NCT00006096 Phase 3 cisplatin
4 Chemotherapy, Radiation Therapy, and Surgery in Treating Patients With Locally Advanced Cancer of the Vulva Completed NCT00068406 Phase 2 Cisplatin
5 Erlotinib in Women With Squamous Cell Carcinoma of the Vulvar Completed NCT00476476 Phase 2 Erlotinib
6 Paclitaxel in Treating Patients With Locally Advanced, Metastatic, or Recurrent Cancer of the Vulva Completed NCT00014599 Phase 2 paclitaxel
7 Radiation Therapy, Gemcitabine Hydrochloride, and Cisplatin in Treating Patients With Locally Advanced Squamous Cell Cancer of the Vulva Recruiting NCT01595061 Phase 2 Cisplatin;Gemcitabine Hydrochloride
8 Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin Cancers Recruiting NCT02978625 Phase 2
9 Triapine With Chemotherapy and Radiation Therapy in Treating Patients With IB2-IVA Cervical or Vulvar Cancer Suspended NCT02595879 Phase 1 Cisplatin;Triapine
10 Interest of the Confocal Microscope in the Diagnosis of Epidermoid Carcinoma of the Vulva and Their Precursors Unknown status NCT02735109 Not Applicable
11 Conservative Management With Isolated Sentinel Lymph Node Biopsy in Vulvar Cancer Patients. Completed NCT00315159 Not Applicable
12 Collecting Tumor Samples From Patients With Gynecological Tumors Completed NCT00897442
13 OX-40 Protein Expression in the Sentinel Lymph Nodes of Patients With Cancer Completed NCT00900302
14 Observation in Patients With Early-Stage Vulvar Cancer Undergoing Sentinel Lymph Node Dissection Active, not recruiting NCT01500512

Search NIH Clinical Center for Vulva Squamous Cell Carcinoma

Genetic Tests for Vulva Squamous Cell Carcinoma

Anatomical Context for Vulva Squamous Cell Carcinoma

The Foundational Model of Anatomy Ontology organs/tissues related to Vulva Squamous Cell Carcinoma:

19
The Epidermis Of The Vulvar Tissue

MalaCards organs/tissues related to Vulva Squamous Cell Carcinoma:

41
Lymph Node, Skin

Publications for Vulva Squamous Cell Carcinoma

Articles related to Vulva Squamous Cell Carcinoma:

# Title Authors Year
1
Tumor-to-tumor metastasis with endometrial carcinoma metastatic to squamous cell carcinoma of vulva: the first reported case. ( 24283863 )
2013
2
The definition of optimal inguinal femoral nodal dissection in the management of vulva squamous cell carcinoma. ( 17473950 )
2007

Variations for Vulva Squamous Cell Carcinoma

Cosmic variations for Vulva Squamous Cell Carcinoma:

9
(show top 50) (show all 130)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM10662 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.743G>A p.R248Q 17:7674220-7674220 17
2 COSM10905 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.451C>T p.P151S 17:7675161-7675161 17
3 COSM44645 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.527G>C p.C176S 17:7675085-7675085 17
4 COSM6932 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.733G>A p.G245S 17:7674230-7674230 17
5 COSM10659 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.817C>T p.R273C 17:7673803-7673803 17
6 COSM10656 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.742C>T p.R248W 17:7674221-7674221 17
7 COSM10660 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.818G>A p.R273H 17:7673802-7673802 17
8 COSM10724 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.839G>C p.R280T 17:7673781-7673781 17
9 COSM10648 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.524G>A p.R175H 17:7675088-7675088 17
10 COSM43559 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.517G>T p.V173L 17:7675095-7675095 17
11 COSM45114 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.702C>A p.Y234* 17:7674261-7674261 17
12 COSM10867 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.797G>A p.G266E 17:7673823-7673823 17
13 COSM44365 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.607G>T p.V203L 17:7674924-7674924 17
14 COSM10726 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.856G>A p.E286K 17:7673764-7673764 17
15 COSM10790 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.455C>T p.P152L 17:7675157-7675157 17
16 COSM43861 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.502C>T p.H168Y 17:7675110-7675110 17
17 COSM44319 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.405C>A p.C135* 17:7675207-7675207 17
18 COSM43734 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.528C>A p.C176* 17:7675084-7675084 17
19 COSM43905 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.590T>G p.V197G 17:7674941-7674941 17
20 COSM10667 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.646G>A p.V216M 17:7674885-7674885 17
21 COSM45679 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.868C>T p.R290C 17:7673752-7673752 17
22 COSM10704 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.844C>T p.R282W 17:7673776-7673776 17
23 COSM10768 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.535C>T p.H179Y 17:7675077-7675077 17
24 COSM43837 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.843C>G p.D281E 17:7673777-7673777 17
25 COSM10722 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.853G>A p.E285K 17:7673767-7673767 17
26 COSM11133 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.725G>C p.C242S 17:7674238-7674238 17
27 COSM11998 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.534C>A p.H178Q 17:7675078-7675078 17
28 COSM10663 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.916C>T p.R306* 17:7673704-7673704 17
29 COSM43657 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.569C>T p.P190L 17:7674962-7674962 17
30 COSM43955 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.514G>A p.V172I 17:7675098-7675098 17
31 COSM44942 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.339C>G p.F113L 17:7676030-7676030 17
32 COSM44808 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.503A>C p.H168P 17:7675109-7675109 17
33 COSM11073 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.1024C>T p.R342* 17:7670685-7670685 17
34 COSM10812 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.722C>T p.S241F 17:7674241-7674241 17
35 COSM6845277 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.670G>C p.E224Q 17:7674861-7674861 17
36 COSM43818 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.413C>T p.A138V 17:7675199-7675199 17
37 COSM10735 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.638G>A p.R213Q 17:7674893-7674893 17
38 COSM44120 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.532C>T p.H178Y 17:7675080-7675080 17
39 COSM44383 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.518T>G p.V173G 17:7675094-7675094 17
40 COSM44094 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.716A>G p.N239S 17:7674247-7674247 17
41 COSM10647 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.404G>T p.C135F 17:7675208-7675208 17
42 COSM10645 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.527G>T p.C176F 17:7675085-7675085 17
43 COSM46185 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.775G>C p.D259H 17:7674188-7674188 17
44 COSM43689 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.482C>T p.A161V 17:7675130-7675130 17
45 COSM10771 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.749C>T p.P250L 17:7674214-7674214 17
46 COSM10935 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.722C>A p.S241Y 17:7674241-7674241 17
47 COSM10758 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.659A>G p.Y220C 17:7674872-7674872 17
48 COSM11166 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.406C>T p.Q136* 17:7675206-7675206 17
49 COSM119021 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.993+1G>C p.? 17:7673534-7673534 17
50 COSM43947 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.614A>G p.Y205C 17:7674917-7674917 17

Expression for Vulva Squamous Cell Carcinoma

Search GEO for disease gene expression data for Vulva Squamous Cell Carcinoma.

Pathways for Vulva Squamous Cell Carcinoma

Pathways related to Vulva Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.03 CDKN2A TP53
2 10.76 CDKN2A TP53
3 10.5 CDKN2A TP53
4
Show member pathways
10.3 CDKN2A TP53
5 9.7 MEG3 TP53

GO Terms for Vulva Squamous Cell Carcinoma

Biological processes related to Vulva Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 replicative senescence GO:0090399 8.62 CDKN2A TP53

Molecular functions related to Vulva Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 disordered domain specific binding GO:0097718 8.62 CDKN2A TP53

Sources for Vulva Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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