MCID: VLV034
MIFTS: 37

Vulva Squamous Cell Carcinoma

Categories: Cancer diseases, Rare diseases, Reproductive diseases, Skin diseases

Aliases & Classifications for Vulva Squamous Cell Carcinoma

MalaCards integrated aliases for Vulva Squamous Cell Carcinoma:

Name: Vulva Squamous Cell Carcinoma 12 15
Squamous Cell Carcinoma of Vulva 12 73
Vulvar Squamous Cell Carcinoma 12 59
Squamous Cell Carcinoma of the Vulva 59
Vulvar Epidermoid Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2101
NCIt 50 C4052
Orphanet 59 ORPHA494448
UMLS 73 C0280856

Summaries for Vulva Squamous Cell Carcinoma

Disease Ontology : 12 A vulva carcinoma and has material basis in squamous cells and is located in the epidermis of the vulvar tissue.

MalaCards based summary : Vulva Squamous Cell Carcinoma, also known as squamous cell carcinoma of vulva, is related to keratinizing squamous cell carcinoma and verrucous carcinoma. An important gene associated with Vulva Squamous Cell Carcinoma is MALAT1 (Metastasis Associated Lung Adenocarcinoma Transcript 1), and among its related pathways/superpathways are Photodynamic therapy-induced AP-1 survival signaling. and Oncogene Induced Senescence. The drugs Cisplatin and Paclitaxel have been mentioned in the context of this disorder. Affiliated tissues include lymph node, skin and lung.

Related Diseases for Vulva Squamous Cell Carcinoma

Diseases related to Vulva Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 127)
# Related Disease Score Top Affiliating Genes
1 keratinizing squamous cell carcinoma 30.3 CDKN2A TP53
2 verrucous carcinoma 30.2 CDKN2A TP53
3 squamous cell carcinoma 30.2 CDKN2A MALAT1 SERPINB3 TP53
4 vulva verrucous carcinoma 11.3
5 vulvar basaloid squamous cell carcinoma 11.3
6 vulvar keratinizing squamous cell carcinoma 11.3
7 vulvar non-keratinizing squamous cell carcinoma 11.3
8 ovarian epithelial cancer 10.2 MALAT1 MEG3
9 vulvar dystrophy 10.2
10 bladder squamous cell carcinoma 10.2 CDKN2A TP53
11 spitz nevus 10.2 CDKN2A TP53
12 bladder carcinoma in situ 10.2 CDKN2A TP53
13 scrotal carcinoma 10.2 CDKN2A TP53
14 nasal cavity adenocarcinoma 10.2 CDKN2A TP53
15 bartholin's gland disease 10.2 CDKN2A TP53
16 anal squamous cell carcinoma 10.2 CDKN2A TP53
17 megaesophagus 10.2 CDKN2A TP53
18 glycogen-rich clear cell breast carcinoma 10.2 CDKN2A TP53
19 embryonal sarcoma 10.2 MALAT1 TP53
20 gastric adenosquamous carcinoma 10.2 CDKN2A TP53
21 pituitary adenoma 10.2 MALAT1 MEG3
22 anogenital venereal wart 10.2 CDKN2A TP53
23 oral leukoplakia 10.2 CDKN2A TP53
24 meningeal melanomatosis 10.2 CDKN2A TP53
25 suppressor of tumorigenicity 3 10.2 CDKN2A TP53
26 dedifferentiated liposarcoma 10.2 CDKN2A TP53
27 endocervical adenocarcinoma 10.2 CDKN2A TP53
28 penile disease 10.2 CDKN2A TP53
29 cervix small cell carcinoma 10.2 CDKN2A TP53
30 necrotizing sialometaplasia 10.2 CDKN2A TP53
31 tongue disease 10.2 CDKN2A TP53
32 biliary tract neoplasm 10.2 CDKN2A TP53
33 optic nerve neoplasm 10.2 CDKN2A TP53
34 juvenile pilocytic astrocytoma 10.2 CDKN2A TP53
35 tonsil cancer 10.2 CDKN2A TP53
36 recessive dystrophic epidermolysis bullosa 10.2 CDKN2A TP53
37 squamous cell papilloma 10.2 CDKN2A TP53
38 laryngeal disease 10.2 CDKN2A TP53
39 barrett's adenocarcinoma 10.2 CDKN2A TP53
40 oropharynx cancer 10.1 CDKN2A TP53
41 pharynx cancer 10.1 CDKN2A TP53
42 cervix carcinoma 10.1 CDKN2A TP53
43 pancreatic ductal carcinoma 10.1 CDKN2A TP53
44 skin squamous cell carcinoma 10.1 CDKN2A TP53
45 anal canal squamous cell carcinoma 10.1 CDKN2A SERPINB3
46 inverted papilloma 10.1 CDKN2A TP53
47 cellular schwannoma 10.1 CDKN2A TP53
48 anus cancer 10.1 CDKN2A SERPINB3
49 penile cancer 10.1 CDKN2A TP53
50 eccrine sweat gland neoplasm 10.1 KRT17 TP53

Graphical network of the top 20 diseases related to Vulva Squamous Cell Carcinoma:



Diseases related to Vulva Squamous Cell Carcinoma

Symptoms & Phenotypes for Vulva Squamous Cell Carcinoma

Drugs & Therapeutics for Vulva Squamous Cell Carcinoma

Drugs for Vulva Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 3,Phase 2 15663-27-1 2767 441203 84093
2
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
3
Gemcitabine Approved Phase 2 95058-81-4 60750
4
Nivolumab Approved Phase 2 946414-94-4
5
Erlotinib Hydrochloride Phase 2 183319-69-9 176871
6 Protein Kinase Inhibitors Phase 2
7 Antineoplastic Agents, Phytogenic Phase 2
8 Antimitotic Agents Phase 2
9 Albumin-Bound Paclitaxel Phase 2
10 Antibodies Phase 2
11 Immunoglobulins Phase 2
12 Antimetabolites Phase 2
13 Immunosuppressive Agents Phase 2
14 Antiviral Agents Phase 2
15 Antimetabolites, Antineoplastic Phase 2
16 Immunologic Factors Phase 2
17 Anti-Infective Agents Phase 2
18 Antibodies, Monoclonal Phase 2
19
Formaldehyde Approved, Vet_approved 50-00-0 712
20
Dimenhydrinate Approved 523-87-5 441281
21
Hydrogen peroxide Approved, Vet_approved 7722-84-1 784
22
Ethanol Approved 64-17-5 702
23 Pharmaceutical Solutions

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Radiation Therapy or Surgery in Treating Patients With Previously Untreated Vulva Cancer With Positive Groin Lymph Nodes Completed NCT00898352 Phase 3
2 Lymphatic Mapping in Treating Patients With Stage I or Stage II Cancer of the Vulva Completed NCT00003325 Phase 3
3 Radiation Therapy With or Without Cisplatin in Treating Patients With Stage I, Stage II, or Stage III Cancer of the Vulva Terminated NCT00006096 Phase 3 cisplatin
4 Chemotherapy, Radiation Therapy, and Surgery in Treating Patients With Locally Advanced Cancer of the Vulva Completed NCT00068406 Phase 2 Cisplatin
5 Erlotinib in Women With Squamous Cell Carcinoma of the Vulvar Completed NCT00476476 Phase 2 Erlotinib
6 Paclitaxel in Treating Patients With Locally Advanced, Metastatic, or Recurrent Cancer of the Vulva Completed NCT00014599 Phase 2 paclitaxel
7 Radiation Therapy, Gemcitabine Hydrochloride, and Cisplatin in Treating Patients With Locally Advanced Squamous Cell Cancer of the Vulva Recruiting NCT01595061 Phase 2 Cisplatin;Gemcitabine Hydrochloride
8 Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin Cancers Recruiting NCT02978625 Phase 2
9 Interest of the Confocal Microscope in the Diagnosis of Epidermoid Carcinoma of the Vulva and Their Precursors Unknown status NCT02735109 Not Applicable
10 Conservative Management With Isolated Sentinel Lymph Node Biopsy in Vulvar Cancer Patients. Completed NCT00315159 Not Applicable
11 Collecting Tumor Samples From Patients With Gynecological Tumors Completed NCT00897442
12 OX-40 Protein Expression in the Sentinel Lymph Nodes of Patients With Cancer Completed NCT00900302
13 Biospecimen Collection and Testing for the Prevalence of Anal Dysplasia and Anal Cancer in Patients With Cervical, Vaginal and Vulvar Dysplasia and Cancer Recruiting NCT02140021 Not Applicable
14 Observation in Patients With Early-Stage Vulvar Cancer Undergoing Sentinel Lymph Node Dissection Active, not recruiting NCT01500512

Search NIH Clinical Center for Vulva Squamous Cell Carcinoma

Genetic Tests for Vulva Squamous Cell Carcinoma

Anatomical Context for Vulva Squamous Cell Carcinoma

MalaCards organs/tissues related to Vulva Squamous Cell Carcinoma:

41
Lymph Node, Skin, Lung, Kidney, Bone, Tongue, Cervix

The Foundational Model of Anatomy Ontology organs/tissues related to Vulva Squamous Cell Carcinoma:

19
The Epidermis Of The Vulvar Tissue

Publications for Vulva Squamous Cell Carcinoma

Articles related to Vulva Squamous Cell Carcinoma:

# Title Authors Year
1
Impact of re-excision of residual adjacent vulvar intraepithelial neoplasia (VIN III) and histological tumour-free margin (hTFM) on survival in primary squamous cell carcinoma of vulva. ( 30187190 )
2018
2
Surgical management for squamous cell carcinoma of vulva. ( 27642483 )
2016
3
Tumor-to-tumor metastasis with endometrial carcinoma metastatic to squamous cell carcinoma of vulva: the first reported case. ( 24283863 )
2013
4
Verrucous squamous cell carcinoma of vulva simulating multiple epidermal inclusion cysts. ( 23919011 )
2013
5
Cyberknife radiosurgery for squamous cell carcinoma of vulva after prior pelvic radiation therapy. ( 18783287 )
2008
6
The definition of optimal inguinal femoral nodal dissection in the management of vulva squamous cell carcinoma. ( 17473950 )
2007
7
Images in pathology. Invasive squamous cell carcinoma of vulva that wanted to be a puppy. ( 17041202 )
2006
8
Invasive squamous cell carcinoma of vulva: prognostic significance of clinicopathologic parameters. ( 15861524 )
2005
9
Concurrent squamous cell carcinoma of vulva and penis in a married couple. ( 3373472 )
1988

Variations for Vulva Squamous Cell Carcinoma

Cosmic variations for Vulva Squamous Cell Carcinoma:

9 (show top 50) (show all 130)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM10662 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.743G>A p.R248Q 17:7674220-7674220 17
2 COSM10905 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.451C>T p.P151S 17:7675161-7675161 17
3 COSM10659 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.817C>T p.R273C 17:7673803-7673803 17
4 COSM10660 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.818G>A p.R273H 17:7673802-7673802 17
5 COSM119021 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.993+1G>C p.? 17:7673534-7673534 17
6 COSM43947 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.614A>G p.Y205C 17:7674917-7674917 17
7 COSM43680 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.523C>T p.R175C 17:7675089-7675089 17
8 COSM6932 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.733G>A p.G245S 17:7674230-7674230 17
9 COSM10656 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.742C>T p.R248W 17:7674221-7674221 17
10 COSM43958 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.843C>T p.D281D 17:7673777-7673777 17
11 COSM10704 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.844C>T p.R282W 17:7673776-7673776 17
12 COSM10724 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.839G>C p.R280T 17:7673781-7673781 17
13 COSM10648 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.524G>A p.R175H 17:7675088-7675088 17
14 COSM43559 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.517G>T p.V173L 17:7675095-7675095 17
15 COSM45114 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.702C>A p.Y234* 17:7674261-7674261 17
16 COSM10867 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.797G>A p.G266E 17:7673823-7673823 17
17 COSM44365 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.607G>T p.V203L 17:7674924-7674924 17
18 COSM10726 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.856G>A p.E286K 17:7673764-7673764 17
19 COSM10790 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.455C>T p.P152L 17:7675157-7675157 17
20 COSM43861 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.502C>T p.H168Y 17:7675110-7675110 17
21 COSM44319 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.405C>A p.C135* 17:7675207-7675207 17
22 COSM43734 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.528C>A p.C176* 17:7675084-7675084 17
23 COSM43905 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.590T>G p.V197G 17:7674941-7674941 17
24 COSM10667 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.646G>A p.V216M 17:7674885-7674885 17
25 COSM45679 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.868C>T p.R290C 17:7673752-7673752 17
26 COSM10768 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.535C>T p.H179Y 17:7675077-7675077 17
27 COSM43837 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.843C>G p.D281E 17:7673777-7673777 17
28 COSM10722 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.853G>A p.E285K 17:7673767-7673767 17
29 COSM11133 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.725G>C p.C242S 17:7674238-7674238 17
30 COSM11998 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.534C>A p.H178Q 17:7675078-7675078 17
31 COSM10663 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.916C>T p.R306* 17:7673704-7673704 17
32 COSM43657 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.569C>T p.P190L 17:7674962-7674962 17
33 COSM43955 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.514G>A p.V172I 17:7675098-7675098 17
34 COSM44942 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.339C>G p.F113L 17:7676030-7676030 17
35 COSM44808 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.503A>C p.H168P 17:7675109-7675109 17
36 COSM11073 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.1024C>T p.R342* 17:7670685-7670685 17
37 COSM10812 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.722C>T p.S241F 17:7674241-7674241 17
38 COSM6845277 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.670G>C p.E224Q 17:7674861-7674861 17
39 COSM43818 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.413C>T p.A138V 17:7675199-7675199 17
40 COSM10735 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.638G>A p.R213Q 17:7674893-7674893 17
41 COSM44120 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.532C>T p.H178Y 17:7675080-7675080 17
42 COSM44383 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.518T>G p.V173G 17:7675094-7675094 17
43 COSM44094 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.716A>G p.N239S 17:7674247-7674247 17
44 COSM10647 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.404G>T p.C135F 17:7675208-7675208 17
45 COSM10645 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.527G>T p.C176F 17:7675085-7675085 17
46 COSM46185 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.775G>C p.D259H 17:7674188-7674188 17
47 COSM43689 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.482C>T p.A161V 17:7675130-7675130 17
48 COSM10771 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.749C>T p.P250L 17:7674214-7674214 17
49 COSM10935 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.722C>A p.S241Y 17:7674241-7674241 17
50 COSM10758 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.659A>G p.Y220C 17:7674872-7674872 17

Expression for Vulva Squamous Cell Carcinoma

Search GEO for disease gene expression data for Vulva Squamous Cell Carcinoma.

Pathways for Vulva Squamous Cell Carcinoma

Pathways related to Vulva Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.03 CDKN2A TP53
2 10.76 CDKN2A TP53
3 10.5 CDKN2A TP53
4
Show member pathways
10.3 CDKN2A TP53
5 9.7 MEG3 TP53

GO Terms for Vulva Squamous Cell Carcinoma

Biological processes related to Vulva Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell growth GO:0030308 9.13 CDKN2A MEG3 TP53
2 replicative senescence GO:0090399 8.62 CDKN2A TP53

Molecular functions related to Vulva Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 disordered domain specific binding GO:0097718 8.62 CDKN2A TP53

Sources for Vulva Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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