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MCID: VLV034
MIFTS: 41

Vulva Squamous Cell Carcinoma

Categories: Cancer diseases, Rare diseases, Reproductive diseases, Skin diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Vulva Squamous Cell Carcinoma

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MalaCards integrated aliases for Vulva Squamous Cell Carcinoma:

Name: Vulva Squamous Cell Carcinoma 12 15
Vulvar Squamous Cell Carcinoma 12 60 17
Squamous Cell Carcinoma of Vulva 12 74
Squamous Cell Carcinoma of the Vulva 60
Vulvar Epidermoid Carcinoma 12

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Reproductive diseases Skin diseases
See all MalaCards categories (disease lists)
Orphanet: 60  
Rare gynaecological and obstetric diseases


External Ids:

Disease Ontology 12 DOID:2101
NCIt 51 C4052
Orphanet 60 ORPHA494448
UMLS 74 C0280856
Sources

Summaries for Vulva Squamous Cell Carcinoma

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Disease Ontology : 12 A vulva carcinoma and has material basis in squamous cells and is located in the epidermis of the vulvar tissue.

MalaCards based summary : Vulva Squamous Cell Carcinoma, also known as vulvar squamous cell carcinoma, is related to keratinizing squamous cell carcinoma and basaloid squamous cell carcinoma. An important gene associated with Vulva Squamous Cell Carcinoma is MALAT1 (Metastasis Associated Lung Adenocarcinoma Transcript 1), and among its related pathways/superpathways are Photodynamic therapy-induced AP-1 survival signaling. and Oncogene Induced Senescence. The drugs Cisplatin and Paclitaxel have been mentioned in the context of this disorder. Affiliated tissues include lymph node, skin and cervix.

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Related Diseases for Vulva Squamous Cell Carcinoma

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Diseases related to Vulva Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 132)
# Related Disease Score Top Affiliating Genes
1 keratinizing squamous cell carcinoma 30.5 CDKN2A TP53
2 basaloid squamous cell carcinoma 30.4 CDKN2A TP53
3 verrucous carcinoma 30.4 CDKN2A TP53
4 squamous cell papilloma 30.4 CDKN2A TP53
5 in situ carcinoma 30.2 CDKN2A TP53
6 squamous cell carcinoma 30.0 CDKN2A MALAT1 SERPINB3 TP53
7 melanoma 29.9 CDKN2A MALAT1 MEG3 TP53
8 vulva cancer 29.6 CDKN2A PLXDC2 SERPINB3 SH3GL2 TP53
9 vulva verrucous carcinoma 11.3
10 vulvar basaloid squamous cell carcinoma 11.3
11 vulvar keratinizing squamous cell carcinoma 11.3
12 vulvar non-keratinizing squamous cell carcinoma 11.3
13 lichen sclerosus 10.6
14 ovarian epithelial cancer 10.4 MALAT1 MEG3
15 bladder squamous cell carcinoma 10.3 CDKN2A TP53
16 spitz nevus 10.3 CDKN2A TP53
17 bladder carcinoma in situ 10.3 CDKN2A TP53
18 scrotal carcinoma 10.3 CDKN2A TP53
19 thyroid lymphoma 10.3 CDKN2A TP53
20 nasal cavity adenocarcinoma 10.3 CDKN2A TP53
21 bartholin's gland disease 10.3 CDKN2A TP53
22 anal squamous cell carcinoma 10.3 CDKN2A TP53
23 megaesophagus 10.3 CDKN2A TP53
24 glycogen-rich clear cell breast carcinoma 10.3 CDKN2A TP53
25 gastric adenosquamous carcinoma 10.3 CDKN2A TP53
26 pituitary adenoma 10.3 MALAT1 MEG3
27 anogenital venereal wart 10.3 CDKN2A TP53
28 cervix uteri carcinoma in situ 10.3 CDKN2A TP53
29 embryonal sarcoma 10.3 MALAT1 TP53
30 uterus carcinoma in situ 10.3 CDKN2A TP53
31 oral leukoplakia 10.3 CDKN2A TP53
32 meningeal melanomatosis 10.3 CDKN2A TP53
33 suppressor of tumorigenicity 3 10.3 CDKN2A TP53
34 dedifferentiated liposarcoma 10.3 CDKN2A TP53
35 endocervical adenocarcinoma 10.3 CDKN2A TP53
36 cervical adenocarcinoma 10.3 CDKN2A TP53
37 penile disease 10.3 CDKN2A TP53
38 cervix small cell carcinoma 10.3 CDKN2A TP53
39 necrotizing sialometaplasia 10.3 CDKN2A TP53
40 tongue disease 10.3 CDKN2A TP53
41 optic nerve neoplasm 10.3 CDKN2A TP53
42 juvenile pilocytic astrocytoma 10.3 CDKN2A TP53
43 tonsil cancer 10.3 CDKN2A TP53
44 pre-malignant neoplasm 10.3 CDKN2A TP53
45 laryngeal disease 10.2 CDKN2A TP53
46 barrett's adenocarcinoma 10.2 CDKN2A TP53
47 vulvar dystrophy 10.2
48 oropharynx cancer 10.2 CDKN2A TP53
49 pharynx cancer 10.2 CDKN2A TP53
50 pancreatic ductal carcinoma 10.2 CDKN2A TP53

Graphical network of the top 20 diseases related to Vulva Squamous Cell Carcinoma:



Diseases related to Vulva Squamous Cell Carcinoma
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Symptoms & Phenotypes for Vulva Squamous Cell Carcinoma

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Drugs & Therapeutics for Vulva Squamous Cell Carcinoma

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Drugs for Vulva Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 3,Phase 2 15663-27-1 2767 441203 84093
2
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
3
Gemcitabine Approved Phase 2 95058-81-4 60750
4
nivolumab Approved Phase 2 946414-94-4
5
Talimogene laherparepvec Approved, Experimental, Investigational Phase 2 1187560-31-1
6 Protein Kinase Inhibitors Phase 2
7
Erlotinib Hydrochloride Phase 2 183319-69-9 176871
8 Antineoplastic Agents, Phytogenic Phase 2
9 Antimitotic Agents Phase 2
10 Albumin-Bound Paclitaxel Phase 2
11 Immunologic Factors Phase 2,Phase 1
12 Antimetabolites Phase 2
13 Antimetabolites, Antineoplastic Phase 2
14 Immunosuppressive Agents Phase 2
15 Antiviral Agents Phase 2
16 Anti-Infective Agents Phase 2
17 Antineoplastic Agents, Immunological Phase 2,Phase 1
18
Durvalumab Approved, Investigational Phase 1 1428935-60-7
19
Ipilimumab Approved Phase 1 477202-00-9
20
Tremelimumab Investigational Phase 1 745013-59-6
21 Immunoglobulins Phase 1
22 Antibodies Phase 1
23 Antibodies, Monoclonal Phase 1
24 Immunoglobulin G Phase 1
25
Formaldehyde Approved, Vet_approved 50-00-0 712
26
Ethanol Approved 64-17-5 702
27
Dimenhydrinate Approved 523-87-5 441281
28
Hydrogen peroxide Approved, Vet_approved 7722-84-1 784
29 Pharmaceutical Solutions

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 Radiation Therapy or Surgery in Treating Patients With Previously Untreated Vulva Cancer With Positive Groin Lymph Nodes Completed NCT00898352 Phase 3
2 Lymphatic Mapping in Treating Patients With Stage I or Stage II Cancer of the Vulva Completed NCT00003325 Phase 3
3 Radiation Therapy With or Without Cisplatin in Treating Patients With Stage I, Stage II, or Stage III Cancer of the Vulva Terminated NCT00006096 Phase 3 cisplatin
4 Chemotherapy, Radiation Therapy, and Surgery in Treating Patients With Locally Advanced Cancer of the Vulva Completed NCT00068406 Phase 2 Cisplatin
5 Erlotinib in Women With Squamous Cell Carcinoma of the Vulvar Completed NCT00476476 Phase 2 Erlotinib
6 Paclitaxel in Treating Patients With Locally Advanced, Metastatic, or Recurrent Cancer of the Vulva Completed NCT00014599 Phase 2 paclitaxel
7 Radiation Therapy, Gemcitabine Hydrochloride, and Cisplatin in Treating Patients With Locally Advanced Squamous Cell Cancer of the Vulva Recruiting NCT01595061 Phase 2 Cisplatin;Gemcitabine Hydrochloride
8 Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin Cancers Recruiting NCT02978625 Phase 2
9 Stereotactic Body Radiation Therapy, Tremelimumab and Durvalumab in Treating Participants With Recurrent or Metastatic Cervical, Vaginal, or Vulvar Cancers Recruiting NCT03452332 Phase 1
10 Interest of the Confocal Microscope in the Diagnosis of Epidermoid Carcinoma of the Vulva and Their Precursors Unknown status NCT02735109 Not Applicable
11 Conservative Management With Isolated Sentinel Lymph Node Biopsy in Vulvar Cancer Patients. Completed NCT00315159 Not Applicable
12 Collecting Tumor Samples From Patients With Gynecological Tumors Completed NCT00897442
13 OX-40 Protein Expression in the Sentinel Lymph Nodes of Patients With Cancer Completed NCT00900302
14 Biospecimen Collection and Testing for the Prevalence of Anal Dysplasia and Anal Cancer in Patients With Cervical, Vaginal and Vulvar Dysplasia and Cancer Recruiting NCT02140021 Not Applicable
15 Observation in Patients With Early-Stage Vulvar Cancer Undergoing Sentinel Lymph Node Dissection Active, not recruiting NCT01500512

Search NIH Clinical Center for Vulva Squamous Cell Carcinoma

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Genetic Tests for Vulva Squamous Cell Carcinoma

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Anatomical Context for Vulva Squamous Cell Carcinoma

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MalaCards organs/tissues related to Vulva Squamous Cell Carcinoma:

42
Lymph Node, Skin, Cervix, Tongue, B Cells, Testes, T Cells

The Foundational Model of Anatomy Ontology organs/tissues related to Vulva Squamous Cell Carcinoma:

20
The Epidermis Of The Vulvar Tissue
Sources

Publications for Vulva Squamous Cell Carcinoma

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Articles related to Vulva Squamous Cell Carcinoma:

(show top 50) (show all 153)
# Title Authors Year
1
Vulvar Squamous Cell Carcinoma in a Patient With Vulvar Lichen Sclerosus. ( 31066866 )
2019
2
Margin status revisited in vulvar squamous cell carcinoma. ( 31109660 )
2019
3
LRIG1‑2 and LMO7 immunoreactivity in vulvar squamous cell carcinoma: Association with prognosis in relation to HPV‑DNA and p16INK4a status. ( 31059071 )
2019
4
Measuring the depth of invasion in vulvar squamous cell carcinoma: interobserver agreement and pitfalls. ( 31021414 )
2019
5
HLA-G, HLA-E, and IDO overexpression predicts a worse survival of Tunisian patients with vulvar squamous cell carcinoma. ( 30907063 )
2019
6
Superficially invasive stage IA vulvar squamous cell carcinoma-therapy and prognosis. ( 30622111 )
2019
7
Tumor cell-specific Serpin A1 expression in vulvar squamous cell carcinoma. ( 30607583 )
2019
8
MRI evaluation of vulvar squamous-cell carcinoma in fresh radical local excision specimens for cancer localization and prediction of surgical tumor-free margins. ( 30431192 )
2019
9
Time series analysis of TP53 gene mutations in recurrent HPV-negative vulvar squamous cell carcinoma. ( 30291345 )
2019
10
Association of Retinoic Acid Receptor β Gene With Onset and Progression of Lichen Sclerosus-Associated Vulvar Squamous Cell Carcinoma. ( 29898214 )
2018
11
Prognostic Significance of Human Papilloma Virus and p16 Expression in Patients with Vulvar Squamous Cell Carcinoma who Received Radiotherapy. ( 29449057 )
2018
12
Astragaloside IV inhibits cell proliferation in vulvar squamous cell carcinoma through the TGF-β/Smad signaling pathway. ( 30536730 )
2018
13
Human papillomavirus and nonhuman papillomavirus pathways to vulvar squamous cell carcinoma: A review. ( 30093165 )
2018
14
Prognostic impact of reduced tumor-free margin distance on long-term survival in FIGO stage IB/II vulvar squamous cell carcinoma. ( 30022627 )
2018
15
Evaluation of CHK1 activation in vulvar squamous cell carcinoma and its potential as a therapeutic target in vitro. ( 29963769 )
2018
16
Trends and Outcomes of Sentinel Lymph Node Biopsy in Early-stage Vulvar Squamous Cell Carcinoma: A Population-based Study. ( 29896279 )
2018
17
Prognostic Value of the Number of Removed Lymph Nodes in Vulvar Squamous Cell Carcinoma Patients With Node-Positive Disease: A Population-Based Study. ( 29900126 )
2018
18
Vulvar intraepithelial neoplasia and vulvar squamous cell carcinoma: differential dermoscopic features in a case series, and a progression model. ( 29315730 )
2018
19
Evaluation of AJCC and an Alternative Tumor Classification System for Primary Vulvar Squamous Cell Carcinoma. ( 29295880 )
2018
20
The Prevalence of Lichen Sclerosus in Patients With Vulvar Squamous Cell Carcinoma. ( 27801760 )
2017
21
Adjuvant Radiation Therapy for Margin-Positive Vulvar Squamous Cell Carcinoma: Defining the Ideal Dose-Response Using the National Cancer Data Base. ( 27843030 )
2017
22
Human papillomavirus (HPV)-independent vulvar squamous cell carcinoma has a worse prognosis than HPV-associated disease: a retrospective cohort study. ( 28257152 )
2017
23
Vulvar Squamous Cell Carcinoma (VSCC) as Two Diseases: HPV Status Identifies Distinct Mutational Profiles Including Oncogenic Fibroblast Growth Factor Receptor 3. ( 28377483 )
2017
24
Local immune response depends on p16INK4a status of primary tumor in vulvar squamous cell carcinoma. ( 28515351 )
2017
25
Cutaneous metastasis from vulvar squamous cell carcinoma: a rare occurrence that should not be forgotten. ( 28657384 )
2017
26
PD-L1 expression on immune cells is a favorable prognostic factor for vulvar squamous cell carcinoma patients. ( 29163797 )
2017
27
Vulvar squamous cell carcinoma aggressiveness is associated with differential expression of collagen and STAT1. ( 29225558 )
2017
28
Metastastic vulvar squamous cell carcinoma mimicking genital herpes. ( 27752532 )
2016
29
Herpes simplex virus infection of vulvar squamous cell carcinoma. ( 27020215 )
2016
30
Hypermethylation-Induced Inactivation of the IRF6 Gene as a Possible Early Event in Progression of Vulvar Squamous Cell Carcinoma Associated With Lichen Sclerosus. ( 27223861 )
2016
31
Lichen Sclerosus: Incidence and Risk of Vulvar Squamous Cell Carcinoma. ( 27257093 )
2016
32
The role of RhoA in vulvar squamous cell carcinoma: a carcinogenesis, progression, and target therapy marker. ( 26409448 )
2016
33
miRNA expression profile of vulvar squamous cell carcinoma and identification of the oncogenic role of miR-590-5p. ( 26498065 )
2016
34
p16 Immunostaining Allows for Accurate Subclassification of Vulvar Squamous Cell Carcinoma Into HPV-Associated and HPV-Independent Cases. ( 26630231 )
2016
35
Repeat sentinel lymph node procedure in patients with recurrent vulvar squamous cell carcinoma is feasible. ( 26797295 )
2016
36
The role of cofilin-l in vulvar squamous cell carcinoma: A marker of carcinogenesis, progression and targeted therapy. ( 26936386 )
2016
37
Skin metastases of vulvar squamous cell carcinoma. Presentation of a rare case. ( 27048124 )
2016
38
Rare cutaneous metastasis in vulvar squamous cell carcinoma without any distant organ spread. ( 27169481 )
2016
39
The forgotten woman's cancer: vulvar squamous cell carcinoma (VSCC) and a targeted approach to therapy. ( 27329249 )
2016
40
Adjacent Lichen Sclerosis predicts local recurrence and second field tumour in women with vulvar squamous cell carcinoma. ( 27396942 )
2016
41
Tumour-free margins in vulvar squamous cell carcinoma: Does distance really matter? ( 27497345 )
2016
42
Long non-coding RNA expression profile in vulvar squamous cell carcinoma and its clinical significance. ( 27633334 )
2016
43
Risk factors and treatment for recurrent vulvar squamous cell carcinoma. ( 27637349 )
2016
44
Unusual pleural effusion from vulvar squamous cell carcinoma: report of a case and review of the literature. ( 28195268 )
2016
45
Reduction in ERRα is associated with lichen sclerosus and vulvar squamous cell carcinoma. ( 26499936 )
2015
46
Repeated myiasis in a female vulvar squamous cell carcinoma caused by Lucilia sericata and Sarcophaga crassipalpis. ( 25959933 )
2015
47
An alternative way to measure the depth of invasion of vulvar squamous cell carcinoma in relation to prognosis. ( 25189641 )
2015
48
Genetic and epigenetic changes in vulvar squamous cell carcinoma and its precursor lesions: a review of the current literature. ( 25448458 )
2015
49
Perineural Invasion Is an Independent Pathologic Indicator of Recurrence in Vulvar Squamous Cell Carcinoma. ( 25786085 )
2015
50
Expression of CDK1(Tyr15), pCDK1(Thr161), Cyclin B1 (total) and pCyclin B1(Ser126) in vulvar squamous cell carcinoma and their relations with clinicopatological features and prognosis. ( 25849598 )
2015
Sources

Variations for Vulva Squamous Cell Carcinoma

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Cosmic variations for Vulva Squamous Cell Carcinoma:

9 (show top 50) (show all 130)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)		 Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM6932 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.733G>A p.G245S 17:7674230-7674230 0
2 COSM10905 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.451C>T p.P151S 17:7675161-7675161 0
3 COSM10659 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.817C>T p.R273C 17:7673803-7673803 0
4 COSM10660 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.818G>A p.R273H 17:7673802-7673802 0
5 COSM43680 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.523C>T p.R175C 17:7675089-7675089 0
6 COSM43947 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.614A>G p.Y205C 17:7674917-7674917 0
7 COSM119021 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.993+1G>C p.? 17:7673534-7673534 0
8 COSM10656 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.742C>T p.R248W 17:7674221-7674221 0
9 COSM10724 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.839G>C p.R280T 17:7673781-7673781 0
10 COSM10648 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.524G>A p.R175H 17:7675088-7675088 0
11 COSM10662 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.743G>A p.R248Q 17:7674220-7674220 0
12 COSM43559 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.517G>T p.V173L 17:7675095-7675095 0
13 COSM45114 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.702C>A p.Y234* 17:7674261-7674261 0
14 COSM44365 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.607G>T p.V203L 17:7674924-7674924 0
15 COSM10726 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.856G>A p.E286K 17:7673764-7673764 0
16 COSM10790 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.455C>T p.P152L 17:7675157-7675157 0
17 COSM43861 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.502C>T p.H168Y 17:7675110-7675110 0
18 COSM44319 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.405C>A p.C135* 17:7675207-7675207 0
19 COSM43734 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.528C>A p.C176* 17:7675084-7675084 0
20 COSM10667 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.646G>A p.V216M 17:7674885-7674885 0
21 COSM43905 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.590T>G p.V197G 17:7674941-7674941 0
22 COSM10704 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.844C>T p.R282W 17:7673776-7673776 0
23 COSM45679 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.868C>T p.R290C 17:7673752-7673752 0
24 COSM10768 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.535C>T p.H179Y 17:7675077-7675077 0
25 COSM43837 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.843C>G p.D281E 17:7673777-7673777 0
26 COSM10722 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.853G>A p.E285K 17:7673767-7673767 0
27 COSM11133 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.725G>C p.C242S 17:7674238-7674238 0
28 COSM10663 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.916C>T p.R306* 17:7673704-7673704 0
29 COSM11998 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.534C>A p.H178Q 17:7675078-7675078 0
30 COSM43657 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.569C>T p.P190L 17:7674962-7674962 0
31 COSM43955 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.514G>A p.V172I 17:7675098-7675098 0
32 COSM44808 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.503A>C p.H168P 17:7675109-7675109 0
33 COSM44942 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.339C>G p.F113L 17:7676030-7676030 0
34 COSM11073 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.1024C>T p.R342* 17:7670685-7670685 0
35 COSM10812 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.722C>T p.S241F 17:7674241-7674241 0
36 COSM6845277 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.670G>C p.E224Q 17:7674861-7674861 0
37 COSM43818 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.413C>T p.A138V 17:7675199-7675199 0
38 COSM10735 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.638G>A p.R213Q 17:7674893-7674893 0
39 COSM44120 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.532C>T p.H178Y 17:7675080-7675080 0
40 COSM44383 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.518T>G p.V173G 17:7675094-7675094 0
41 COSM44094 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.716A>G p.N239S 17:7674247-7674247 0
42 COSM10647 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.404G>T p.C135F 17:7675208-7675208 0
43 COSM10645 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.527G>T p.C176F 17:7675085-7675085 0
44 COSM46185 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.775G>C p.D259H 17:7674188-7674188 0
45 COSM10771 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.749C>T p.P250L 17:7674214-7674214 0
46 COSM43689 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.482C>T p.A161V 17:7675130-7675130 0
47 COSM10935 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.722C>A p.S241Y 17:7674241-7674241 0
48 COSM10758 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.659A>G p.Y220C 17:7674872-7674872 0
49 COSM44645 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.527G>C p.C176S 17:7675085-7675085 0
50 COSM11166 TP53 vulva,NS,carcinoma,squamous cell carcinoma c.406C>T p.Q136* 17:7675206-7675206 0
Sources

Expression for Vulva Squamous Cell Carcinoma

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Search GEO for disease gene expression data for Vulva Squamous Cell Carcinoma.
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Pathways for Vulva Squamous Cell Carcinoma

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Pathways related to Vulva Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Photodynamic therapy-induced AP-1 survival signaling. 1
11.03 CDKN2A TP53
2
Oncogene Induced Senescence 67
10.76 CDKN2A TP53
3
Inhibition of Ribosome Biogenesis by p14(ARF) 65
10.5 CDKN2A TP53
4
TP53 Network 1
Show member pathways
 10.3 CDKN2A TP53
5
LncRNA-mediated mechanisms of therapeutic resistance 1
9.7 MEG3 TP53
Sources

GO Terms for Vulva Squamous Cell Carcinoma

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Biological processes related to Vulva Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell growth GO:0030308 9.13 CDKN2A MEG3 TP53
2 replicative senescence GO:0090399 8.62 CDKN2A TP53

Molecular functions related to Vulva Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 disordered domain specific binding GO:0097718 8.62 CDKN2A TP53
Sources

Sources for Vulva Squamous Cell Carcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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