MCID: VLV021
MIFTS: 32

Vulval Paget's Disease

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Vulval Paget's Disease

MalaCards integrated aliases for Vulval Paget's Disease:

Name: Vulval Paget's Disease 12 15
Paget's Disease of Vulva 12 74
Vulvar Paget's Disease 12
Vulval Paget Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2097
NCIt 51 C4027
UMLS 74 C1275217

Summaries for Vulval Paget's Disease

Disease Ontology : 12 A vulva adenocarcinoma that is characterized by distinctive large cells with prominent cytoplasm, referred to as Paget cells and is an intraepithelial neoplasm of epithelial origin expressing apocrine or eccrine glandular-like features.

MalaCards based summary : Vulval Paget's Disease, also known as paget's disease of vulva, is related to mammary paget's disease and endocervical adenocarcinoma. An important gene associated with Vulval Paget's Disease is KRT7 (Keratin 7), and among its related pathways/superpathways is Bladder cancer. The drugs Imiquimod and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include ovary, appendix and skin.

Related Diseases for Vulval Paget's Disease

Diseases related to Vulval Paget's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 194)
# Related Disease Score Top Affiliating Genes
1 mammary paget's disease 30.7 ERBB2 KRT20 KRT7
2 endocervical adenocarcinoma 30.2 CDKN2A KRT20 KRT7
3 sweat gland cancer 30.1 ERBB2 KRT20 KRT7
4 cervical adenocarcinoma 29.9 CDKN2A ERBB2 KRT20 KRT7
5 bladder cancer 29.7 CDKN2A ERBB2 KRT20 UPK3A
6 transitional cell carcinoma 29.5 CDKN2A ERBB2 KRT20 KRT7 UPK3A
7 granulosa cell tumor of the ovary 10.4 ERBB2 KRT7
8 renal pelvis transitional cell carcinoma 10.4 KRT7 UPK3A
9 anus cancer 10.4 CDKN2A KRT7
10 basaloid squamous cell carcinoma 10.4 CDKN2A KRT7
11 cervical adenosquamous carcinoma 10.4 CDKN2A KRT7
12 oropharynx cancer 10.4 CDKN2A KRT7
13 large cell neuroendocrine carcinoma 10.3 KRT20 KRT7
14 ampulla of vater cancer 10.3 KRT20 KRT7
15 small intestine cancer 10.3 KRT20 KRT7
16 cecum adenocarcinoma 10.3 KRT20 KRT7
17 pseudomyxoma peritonei 10.3 KRT20 KRT7
18 clear cell adenocarcinoma 10.3 KRT20 KRT7
19 bronchiolo-alveolar adenocarcinoma 10.3 KRT20 KRT7
20 ovarian cystic teratoma 10.3 KRT20 KRT7
21 cystitis cystica 10.3 KRT20 KRT7
22 intestinal obstruction 10.3 KRT20 KRT7
23 horseshoe kidney 10.3 KRT20 KRT7
24 barrett's adenocarcinoma 10.3 CDKN2A ERBB2
25 in situ carcinoma 10.3 CDKN2A ERBB2
26 inverted transitional papilloma 10.3 CDKN2A KRT7
27 cystadenoma 10.3 KRT20 KRT7
28 tubular adenocarcinoma 10.3 ERBB2 KRT20
29 gastrointestinal system benign neoplasm 10.3 CEACAM5 KRT7
30 bile duct disease 10.3 CEACAM5 KRT7
31 bile duct adenocarcinoma 10.3 CEACAM5 KRT7
32 cystic basal cell carcinoma 10.3 KRT20 KRT7
33 breast papillomatosis 10.3 CDKN2A ERBB2
34 endocervical carcinoma 10.3 CDKN2A KRT7
35 biliary tract disease 10.3 CEACAM5 KRT7
36 bladder carcinoma in situ 10.3 CDKN2A KRT7
37 seminal vesicle adenocarcinoma 10.3 KRT20 KRT7
38 transverse colon cancer 10.3 KRT20 KRT7
39 appendix adenocarcinoma 10.3 KRT20 KRT7
40 nasal cavity cancer 10.3 CDKN2A KRT7
41 malignant syringoma 10.3 KRT20 KRT7
42 urethral diverticulum 10.3 KRT7 UPK3A
43 fallopian tube endometrioid adenocarcinoma 10.3 CDKN2A ERBB2
44 papillary transitional carcinoma 10.3 KRT20 KRT7
45 eyelid carcinoma 10.3 KRT20 KRT7
46 krukenberg carcinoma 10.3 KRT20 KRT7
47 actinic keratosis 10.3 CDKN2A KRT20
48 linitis plastica 10.3 KRT20 KRT7
49 lung acinar adenocarcinoma 10.3 KRT20 KRT7
50 small cell carcinoma of the bladder 10.3 KRT20 KRT7

Graphical network of the top 20 diseases related to Vulval Paget's Disease:



Diseases related to Vulval Paget's Disease

Symptoms & Phenotypes for Vulval Paget's Disease

Drugs & Therapeutics for Vulval Paget's Disease

Drugs for Vulval Paget's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Imiquimod Approved, Investigational Phase 3,Not Applicable 99011-02-6 57469
2
Lidocaine Approved, Vet_approved Phase 3 137-58-6 3676
3
Petrolatum Approved, Investigational Phase 3 8009-03-8
4
Acetaminophen Approved Phase 3 103-90-2 1983
5 Immunologic Factors Phase 3,Not Applicable
6 interferons Phase 3,Not Applicable
7 Interferon Inducers Phase 3,Not Applicable
8 Adjuvants, Immunologic Phase 3,Not Applicable
9 Analgesics Phase 3
10 Dermatologic Agents Phase 3
11 Analgesics, Non-Narcotic Phase 3
12 Peripheral Nervous System Agents Phase 3
13 Antipyretics Phase 3
14 Emollients Phase 3
15
Formaldehyde Approved, Vet_approved 50-00-0 712
16 Methyl 5-aminolevulinate Not Applicable
17 Photosensitizing Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Topical 5% Imiquimod Cream for Vulvar Paget's Disease Active, not recruiting NCT02385188 Phase 3 Imiquimod;paracetamol;lidocaine in Vaseline ointment
2 Evaluation of Trastuzumab In Patients With HER2 Positive Persistent Or Recurrent Vulvar Paget's Disease Withdrawn NCT01427244 Phase 2 trastuzumab
3 Topical Imiquimod in Treating Patients With Recurrent Paget's Disease of the Vulva Completed NCT00504023 Not Applicable imiquimod
4 Collecting Tumor Samples From Patients With Gynecological Tumors Completed NCT00897442
5 Vulvar Paget Disease Recruiting NCT03900975
6 Gynecologic Extramammary Paget's Disease Recruiting NCT03564483
7 PAGETEX® Photodynamic Therapy Device for the Treatment of Extra Mammary Paget's Disease of the Vulva (EMPV). Not yet recruiting NCT03713203 Not Applicable
8 Evaluation of the Role of Vibrational Spectroscopy in the Assessment of Vulval Disease Suspended NCT02223975

Search NIH Clinical Center for Vulval Paget's Disease

Genetic Tests for Vulval Paget's Disease

Anatomical Context for Vulval Paget's Disease

MalaCards organs/tissues related to Vulval Paget's Disease:

42
Ovary, Appendix, Skin, Kidney, Testis, Thymus, Small Intestine

Publications for Vulval Paget's Disease

Articles related to Vulval Paget's Disease:

(show all 11)
# Title Authors Year
1
Bladder Carcinoma Presenting as Paget's Disease of Vulva: An Uncommon Entity. ( 30504985 )
2018
2
Extramammary Paget's disease of vulva: A rare entity. ( 28442808 )
2017
3
Extra Mammary Paget's Disease of Vulva-a Case Report. ( 27872543 )
2016
4
Cervical adenocarcinoma secondary to primary vulval Paget's disease: an unusual form of retrograde spread. ( 25522668 )
2015
5
Successful photodynamic therapy of vulval Paget's disease using a novel patch-based delivery system containing 5-aminolevulinic acid. ( 15383120 )
2004
6
Vulval Paget's disease associated with ovarian teratoma. ( 15763808 )
2004
7
Photodynamic therapy for inoperable vulval Paget's disease using delta-aminolaevulinic acid: successful management of a large skin lesion. ( 10468815 )
1999
8
Laser ablation of recurrent Paget's disease of vulva and perineum. ( 10150074 )
1992
9
Endocervical adenocarcinoma and vulval Paget's disease: a significant association. ( 6254556 )
1980
10
Paget's disease of vulva. ( 4329788 )
1971
11
Apocrine-gland adenocarcinoma and extramammary Paget's disease of vulva; review of the literature and report of a case. ( 13199769 )
1954

Variations for Vulval Paget's Disease

Expression for Vulval Paget's Disease

Search GEO for disease gene expression data for Vulval Paget's Disease.

Pathways for Vulval Paget's Disease

Pathways related to Vulval Paget's Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.66 CDKN2A ERBB2 UPK3A

GO Terms for Vulval Paget's Disease

Cellular components related to Vulval Paget's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apical plasma membrane GO:0016324 8.8 CEACAM5 ERBB2 UPK3A

Biological processes related to Vulval Paget's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of immature T cell proliferation in thymus GO:0033088 8.62 ERBB2 CDKN2A

Sources for Vulval Paget's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....