Vulval Paget's Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Vulval Paget's Disease

MalaCards integrated aliases for Vulval Paget's Disease:

Name: Vulval Paget's Disease ¹² ¹⁵

Paget's Disease of Vulva ¹² ⁷³

Vulvar Paget's Disease ¹²

Vulval Paget Disease ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:2097

NCIt ⁵⁰ C4027

UMLS ⁷³ C1275217

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Summaries for Vulval Paget's Disease

Disease Ontology : ¹² A vulva adenocarcinoma that is characterized by distinctive large cells with prominent cytoplasm, referred to as Paget cells and is an intraepithelial neoplasm of epithelial origin expressing apocrine or eccrine glandular-like features.

MalaCards based summary : Vulval Paget's Disease, also known as paget's disease of vulva, is related to breast secretory carcinoma and granulosa cell tumor of the ovary. An important gene associated with Vulval Paget's Disease is KRT7 (Keratin 7), and among its related pathways/superpathways is Bladder cancer. Affiliated tissues include lung, kidney and ovary.

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Related Diseases for Vulval Paget's Disease

Diseases related to Vulval Paget's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 191)

#	Related Disease	Score	Top Affiliating Genes
1	breast secretory carcinoma	10.3	ERBB2 KRT7
2	granulosa cell tumor of the ovary	10.3	ERBB2 KRT7
3	biliary tract neoplasm	10.3	CDKN2A KRT7
4	necrotizing sialometaplasia	10.3	CDKN2A KRT7
5	anus cancer	10.3	CDKN2A KRT7
6	renal pelvis transitional cell carcinoma	10.3	KRT7 UPK3A
7	basaloid squamous cell carcinoma	10.3	CDKN2A KRT7
8	cervical adenosquamous carcinoma	10.3	CDKN2A KRT7
9	oropharynx cancer	10.3	CDKN2A KRT7
10	barrett's adenocarcinoma	10.2	CDKN2A ERBB2
11	in situ carcinoma	10.2	CDKN2A ERBB2
12	inverted transitional papilloma	10.2	CDKN2A KRT7
13	large cell neuroendocrine carcinoma	10.2	KRT20 KRT7
14	immune system organ benign neoplasm	10.2	KRT20 KRT7
15	ampulla of vater cancer	10.2	KRT20 KRT7
16	small intestine cancer	10.2	KRT20 KRT7
17	appendix cancer	10.2	KRT20 KRT7
18	cystic teratoma	10.2	KRT20 KRT7
19	cecum adenocarcinoma	10.2	KRT20 KRT7
20	prostatic acinar adenocarcinoma	10.2	KRT20 KRT7
21	pseudomyxoma peritonei	10.2	KRT20 KRT7
22	mucinous cystadenocarcinoma	10.2	KRT20 KRT7
23	dysgerminoma	10.2	KRT20 KRT7
24	clear cell adenocarcinoma	10.2	KRT20 KRT7
25	bronchiolo-alveolar adenocarcinoma	10.2	KRT20 KRT7
26	ovarian cystic teratoma	10.2	KRT20 KRT7
27	cystitis cystica	10.2	KRT20 KRT7
28	horseshoe kidney	10.2	KRT20 KRT7
29	cystadenoma	10.2	KRT20 KRT7
30	breast papillomatosis	10.2	CDKN2A ERBB2
31	tubular adenocarcinoma	10.2	ERBB2 KRT20
32	fallopian tube endometrioid adenocarcinoma	10.2	CDKN2A ERBB2
33	endocervical carcinoma	10.2	CDKN2A KRT7
34	bladder carcinoma in situ	10.2	CDKN2A KRT7
35	gastrointestinal system benign neoplasm	10.2	CEACAM5 KRT7
36	nasal cavity cancer	10.2	CDKN2A KRT7
37	bile duct disease	10.2	CEACAM5 KRT7
38	bile duct adenocarcinoma	10.2	CEACAM5 KRT7
39	non-invasive bladder papillary urothelial neoplasm	10.2	PTCRA UPK3A
40	cystic basal cell carcinoma	10.2	KRT20 KRT7
41	actinic keratosis	10.2	CDKN2A KRT20
42	seminal vesicle adenocarcinoma	10.2	KRT20 KRT7
43	transverse colon cancer	10.2	KRT20 KRT7
44	appendix adenocarcinoma	10.2	KRT20 KRT7
45	malignant syringoma	10.2	KRT20 KRT7
46	nasal cavity adenocarcinoma	10.2	CDKN2A KRT7
47	eyelid carcinoma	10.2	KRT20 KRT7
48	anal canal carcinoma	10.2	CDKN2A KRT7
49	krukenberg carcinoma	10.2	KRT20 KRT7
50	urethral diverticulum	10.2	KRT7 UPK3A

Graphical network of the top 20 diseases related to Vulval Paget's Disease:

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Symptoms & Phenotypes for Vulval Paget's Disease

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Drugs & Therapeutics for Vulval Paget's Disease

Search Clinical Trials , NIH Clinical Center for Vulval Paget's Disease

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Genetic Tests for Vulval Paget's Disease

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Anatomical Context for Vulval Paget's Disease

MalaCards organs/tissues related to Vulval Paget's Disease:

⁴¹

Lung, Kidney, Ovary, Prostate, Testis, Thymus, Appendix

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Publications for Vulval Paget's Disease

Articles related to Vulval Paget's Disease:

(show all 11)

#	Title	Authors	Year
1	Bladder Carcinoma Presenting as Paget's Disease of Vulva: An Uncommon Entity. ( 30504985 )	Mehta A...Agarwal P	2018
2	Extramammary Paget's disease of vulva: A rare entity. ( 28442808 )	Yadav S...Rastogi MK	2017
3	Extra Mammary Paget's Disease of Vulva-a Case Report. ( 27872543 )		2016
4	Cervical adenocarcinoma secondary to primary vulval Paget's disease: an unusual form of retrograde spread. ( 25522668 )		2014
5	Vulval Paget's disease associated with ovarian teratoma. ( 15763808 )		2004
6	Successful photodynamic therapy of vulval Paget's disease using a novel patch-based delivery system containing 5-aminolevulinic acid. ( 15383120 )		2004
7	Photodynamic therapy for inoperable vulval Paget's disease using delta-aminolaevulinic acid: successful management of a large skin lesion. ( 10468815 )	Henta T....Ishibashi A.	1999
8	Laser ablation of recurrent Paget's disease of vulva and perineum. ( 10150074 )	Valentine BH...Green E	1992
9	Endocervical adenocarcinoma and vulval Paget's disease: a significant association. ( 6254556 )	McKee P.H....Hertogs K.T.	1980
10	Paget's disease of vulva. ( 4329788 )	Fenn ME...Abell MR	1971
11	Apocrine-gland adenocarcinoma and extramammary Paget's disease of vulva; review of the literature and report of a case. ( 13199769 )	PLACHTA A...SPEER FD	1954

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Genes for Vulval Paget's Disease

Genes related to Vulval Paget's Disease (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	KRT7	Keratin 7	Protein Coding	16.11	DISEASES inferred ¹⁵
2	UPK3A	Uroplakin 3A	Protein Coding	15.87	DISEASES inferred ¹⁵
3	ERBB2	Erb-B2 Receptor Tyrosine Kinase 2	Protein Coding	13.97	DISEASES inferred ¹⁵
4	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	13.94	DISEASES inferred ¹⁵
5	PTCRA	Pre T Cell Antigen Receptor Alpha	Protein Coding	13.78	DISEASES inferred ¹⁵
6	KRT20	Keratin 20	Protein Coding	13.69	DISEASES inferred ¹⁵
7	CD86	CD86 Molecule	Protein Coding	13.2	DISEASES inferred ¹⁵
8	PIP	Prolactin Induced Protein	Protein Coding	6.37	DISEASES inferred ¹⁵
9	LINC01191	Long Intergenic Non-Protein Coding RNA 1191	RNA Gene	5.96	DISEASES inferred ¹⁵
10	CEACAM5	Carcinoembryonic Antigen Related Cell Adhesion Molecule 5	Protein Coding	5.52	DISEASES inferred ¹⁵

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Variations for Vulval Paget's Disease

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Expression for Vulval Paget's Disease

Search GEO for disease gene expression data for Vulval Paget's Disease.

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Pathways for Vulval Paget's Disease

Pathways related to Vulval Paget's Disease according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Bladder cancer ³⁷ ¹	10.66	CDKN2A ERBB2 UPK3A

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GO Terms for Vulval Paget's Disease

Biological processes related to Vulval Paget's Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of immature T cell proliferation in thymus	GO:0033088	8.62	CDKN2A ERBB2

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Sources for Vulval Paget's Disease

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