MCID: VLV021
MIFTS: 32

Vulval Paget's Disease

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Vulval Paget's Disease

MalaCards integrated aliases for Vulval Paget's Disease:

Name: Vulval Paget's Disease 12 15
Paget's Disease of Vulva 12 73
Vulvar Paget's Disease 12
Vulval Paget Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2097
NCIt 50 C4027
UMLS 73 C1275217

Summaries for Vulval Paget's Disease

Disease Ontology : 12 A vulva adenocarcinoma that is characterized by distinctive large cells with prominent cytoplasm, referred to as Paget cells and is an intraepithelial neoplasm of epithelial origin expressing apocrine or eccrine glandular-like features.

MalaCards based summary : Vulval Paget's Disease, also known as paget's disease of vulva, is related to breast secretory carcinoma and granulosa cell tumor of the ovary. An important gene associated with Vulval Paget's Disease is KRT7 (Keratin 7), and among its related pathways/superpathways is Bladder cancer. Affiliated tissues include lung, kidney and ovary.

Related Diseases for Vulval Paget's Disease

Diseases related to Vulval Paget's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 191)
# Related Disease Score Top Affiliating Genes
1 breast secretory carcinoma 10.3 ERBB2 KRT7
2 granulosa cell tumor of the ovary 10.3 ERBB2 KRT7
3 biliary tract neoplasm 10.3 CDKN2A KRT7
4 necrotizing sialometaplasia 10.3 CDKN2A KRT7
5 anus cancer 10.3 CDKN2A KRT7
6 renal pelvis transitional cell carcinoma 10.3 KRT7 UPK3A
7 basaloid squamous cell carcinoma 10.3 CDKN2A KRT7
8 cervical adenosquamous carcinoma 10.3 CDKN2A KRT7
9 oropharynx cancer 10.3 CDKN2A KRT7
10 barrett's adenocarcinoma 10.2 CDKN2A ERBB2
11 in situ carcinoma 10.2 CDKN2A ERBB2
12 inverted transitional papilloma 10.2 CDKN2A KRT7
13 large cell neuroendocrine carcinoma 10.2 KRT20 KRT7
14 immune system organ benign neoplasm 10.2 KRT20 KRT7
15 ampulla of vater cancer 10.2 KRT20 KRT7
16 small intestine cancer 10.2 KRT20 KRT7
17 appendix cancer 10.2 KRT20 KRT7
18 cystic teratoma 10.2 KRT20 KRT7
19 cecum adenocarcinoma 10.2 KRT20 KRT7
20 prostatic acinar adenocarcinoma 10.2 KRT20 KRT7
21 pseudomyxoma peritonei 10.2 KRT20 KRT7
22 mucinous cystadenocarcinoma 10.2 KRT20 KRT7
23 dysgerminoma 10.2 KRT20 KRT7
24 clear cell adenocarcinoma 10.2 KRT20 KRT7
25 bronchiolo-alveolar adenocarcinoma 10.2 KRT20 KRT7
26 ovarian cystic teratoma 10.2 KRT20 KRT7
27 cystitis cystica 10.2 KRT20 KRT7
28 horseshoe kidney 10.2 KRT20 KRT7
29 cystadenoma 10.2 KRT20 KRT7
30 breast papillomatosis 10.2 CDKN2A ERBB2
31 tubular adenocarcinoma 10.2 ERBB2 KRT20
32 fallopian tube endometrioid adenocarcinoma 10.2 CDKN2A ERBB2
33 endocervical carcinoma 10.2 CDKN2A KRT7
34 bladder carcinoma in situ 10.2 CDKN2A KRT7
35 gastrointestinal system benign neoplasm 10.2 CEACAM5 KRT7
36 nasal cavity cancer 10.2 CDKN2A KRT7
37 bile duct disease 10.2 CEACAM5 KRT7
38 bile duct adenocarcinoma 10.2 CEACAM5 KRT7
39 non-invasive bladder papillary urothelial neoplasm 10.2 PTCRA UPK3A
40 cystic basal cell carcinoma 10.2 KRT20 KRT7
41 actinic keratosis 10.2 CDKN2A KRT20
42 seminal vesicle adenocarcinoma 10.2 KRT20 KRT7
43 transverse colon cancer 10.2 KRT20 KRT7
44 appendix adenocarcinoma 10.2 KRT20 KRT7
45 malignant syringoma 10.2 KRT20 KRT7
46 nasal cavity adenocarcinoma 10.2 CDKN2A KRT7
47 eyelid carcinoma 10.2 KRT20 KRT7
48 anal canal carcinoma 10.2 CDKN2A KRT7
49 krukenberg carcinoma 10.2 KRT20 KRT7
50 urethral diverticulum 10.2 KRT7 UPK3A

Graphical network of the top 20 diseases related to Vulval Paget's Disease:



Diseases related to Vulval Paget's Disease

Symptoms & Phenotypes for Vulval Paget's Disease

Drugs & Therapeutics for Vulval Paget's Disease

Search Clinical Trials , NIH Clinical Center for Vulval Paget's Disease

Genetic Tests for Vulval Paget's Disease

Anatomical Context for Vulval Paget's Disease

MalaCards organs/tissues related to Vulval Paget's Disease:

41
Lung, Kidney, Ovary, Prostate, Testis, Thymus, Appendix

Publications for Vulval Paget's Disease

Articles related to Vulval Paget's Disease:

(show all 11)
# Title Authors Year
1
Bladder Carcinoma Presenting as Paget's Disease of Vulva: An Uncommon Entity. ( 30504985 )
2018
2
Extramammary Paget's disease of vulva: A rare entity. ( 28442808 )
2017
3
Extra Mammary Paget's Disease of Vulva-a Case Report. ( 27872543 )
2016
4
Cervical adenocarcinoma secondary to primary vulval Paget's disease: an unusual form of retrograde spread. ( 25522668 )
2014
5
Vulval Paget's disease associated with ovarian teratoma. ( 15763808 )
2004
6
Successful photodynamic therapy of vulval Paget's disease using a novel patch-based delivery system containing 5-aminolevulinic acid. ( 15383120 )
2004
7
Photodynamic therapy for inoperable vulval Paget's disease using delta-aminolaevulinic acid: successful management of a large skin lesion. ( 10468815 )
1999
8
Laser ablation of recurrent Paget's disease of vulva and perineum. ( 10150074 )
1992
9
Endocervical adenocarcinoma and vulval Paget's disease: a significant association. ( 6254556 )
1980
10
Paget's disease of vulva. ( 4329788 )
1971
11
Apocrine-gland adenocarcinoma and extramammary Paget's disease of vulva; review of the literature and report of a case. ( 13199769 )
1954

Variations for Vulval Paget's Disease

Expression for Vulval Paget's Disease

Search GEO for disease gene expression data for Vulval Paget's Disease.

Pathways for Vulval Paget's Disease

Pathways related to Vulval Paget's Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.66 CDKN2A ERBB2 UPK3A

GO Terms for Vulval Paget's Disease

Biological processes related to Vulval Paget's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of immature T cell proliferation in thymus GO:0033088 8.62 CDKN2A ERBB2

Sources for Vulval Paget's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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