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MCID: VLV021
MIFTS: 28

Vulval Paget's Disease

Categories: Cancer diseases, Reproductive diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Vulval Paget's Disease

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MalaCards integrated aliases for Vulval Paget's Disease:

Name: Vulval Paget's Disease 12 15
Paget's Disease of Vulva 12 73
Vulvar Paget's Disease 12
Vulval Paget Disease 12

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:2097
NCIt 50 C4027
SNOMED-CT 68 254898001 403948004
UMLS 73 C1275217
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Summaries for Vulval Paget's Disease

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MalaCards based summary : Vulval Paget's Disease, also known as paget's disease of vulva, is related to renal pelvis transitional cell carcinoma and ovarian benign neoplasm. An important gene associated with Vulval Paget's Disease is KRT7 (Keratin 7), and among its related pathways/superpathways is Bladder cancer. The drugs Imiquimod and Acetaminophen have been mentioned in the context of this disorder. Affiliated tissues include skin.

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Related Diseases for Vulval Paget's Disease

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Diseases related to Vulval Paget's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 180)
# Related Disease Score Top Affiliating Genes
1 renal pelvis transitional cell carcinoma 10.8 KRT7 UPK3A
2 ovarian benign neoplasm 10.8 KRT7 UPK3A
3 inverted transitional papilloma 10.8 CDKN2A KRT7
4 apocrine adenocarcinoma 10.8 ERBB2 KRT7
5 endocervical carcinoma 10.7 CDKN2A KRT7
6 breast papillomatosis 10.7 CDKN2A ERBB2
7 bladder carcinoma in situ 10.7 CDKN2A KRT7
8 fallopian tube endometrioid adenocarcinoma 10.7 CDKN2A ERBB2
9 nasal cavity adenocarcinoma 10.7 CDKN2A KRT7
10 non-invasive bladder papillary urothelial neoplasm 10.7 PTCRA UPK3A
11 cystic basal cell carcinoma 10.7 KRT20 KRT7
12 well-differentiated liposarcoma 10.7 CDKN2A KRT7
13 vaginal benign neoplasm 10.7 KRT20 KRT7
14 seminal vesicle adenocarcinoma 10.7 KRT20 KRT7
15 transverse colon cancer 10.7 KRT20 KRT7
16 appendix adenocarcinoma 10.7 KRT20 KRT7
17 ovarian large-cell neuroendocrine carcinoma 10.7 KRT20 KRT7
18 vaginal adenoma 10.7 KRT20 KRT7
19 vaginal tubulovillous adenoma 10.7 KRT20 KRT7
20 urethral diverticulum 10.7 KRT7 UPK3A
21 eyelid neoplasm 10.6 KRT20 KRT7
22 malignant syringoma 10.6 KRT20 KRT7
23 krukenberg carcinoma 10.6 KRT20 KRT7
24 linitis plastica 10.6 KRT20 KRT7
25 lung acinar adenocarcinoma 10.6 KRT20 KRT7
26 small cell carcinoma of the bladder 10.6 KRT20 KRT7
27 choriocarcinoma of the testis 10.6 KRT7 PTCRA
28 adenoid squamous cell carcinoma 10.6 KRT20 KRT7
29 mixed cell type cancer 10.6 ERBB2 KRT7
30 eccrine sweat gland neoplasm 10.6 KRT20 KRT7
31 oral leukoplakia 10.6 CDKN2A ERBB2
32 intratubular embryonal carcinoma 10.6 KRT20 KRT7
33 ovarian mucinous adenocarcinoma 10.6 KRT20 KRT7
34 gastric diffuse adenocarcinoma 10.6 KRT20 KRT7
35 bladder lymphoma 10.6 KRT20 KRT7
36 nasal cavity squamous cell carcinoma 10.6 CDKN2A KRT7
37 fallopian tube adenocarcinoma 10.6 ERBB2 PTCRA
38 papillary serous adenocarcinoma 10.6 KRT20 KRT7
39 bladder adenocarcinoma 10.6 KRT20 KRT7
40 jejunal adenocarcinoma 10.6 KRT20 KRT7
41 breast secretory carcinoma 10.6 ERBB2 KRT7
42 cutaneous mucoepidermoid carcinoma 10.6 CEACAM5 KRT7
43 anal gland adenocarcinoma 10.6 CEACAM5 KRT7
44 medulloepithelioma 10.6 KRT20 KRT7
45 necrotizing sialometaplasia 10.6 CDKN2A KRT7
46 mucinous adenofibroma 10.6 CEACAM5 KRT7
47 anus adenocarcinoma 10.6 CEACAM5 KRT7
48 malignant spiradenoma 10.6 CEACAM5 KRT7
49 ampulla of vater neoplasm 10.6 KRT20 KRT7
50 bile duct mucoepidermoid carcinoma 10.6 CEACAM5 KRT7

Graphical network of the top 20 diseases related to Vulval Paget's Disease:



Diseases related to Vulval Paget's Disease
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Symptoms & Phenotypes for Vulval Paget's Disease

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Drugs & Therapeutics for Vulval Paget's Disease

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Drugs for Vulval Paget's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Imiquimod Approved, Investigational Phase 3,Not Applicable 99011-02-6 57469
2
Acetaminophen Approved Phase 3 103-90-2 1983
3
Lidocaine Approved, Vet_approved Phase 3 137-58-6 3676
4
Petrolatum Approved, Investigational Phase 3 8009-03-8
5 Adjuvants, Immunologic Phase 3,Not Applicable
6 Interferon Inducers Phase 3,Not Applicable
7 interferons Phase 3,Not Applicable
8 Analgesics Phase 3
9 Analgesics, Non-Narcotic Phase 3
10 Anesthetics Phase 3
11 Anesthetics, Local Phase 3
12 Anti-Arrhythmia Agents Phase 3
13 Antipyretics Phase 3
14 Central Nervous System Depressants Phase 3
15 Dermatologic Agents Phase 3
16 Diuretics, Potassium Sparing Phase 3
17 Emollients Phase 3
18 Peripheral Nervous System Agents Phase 3
19 Sodium Channel Blockers Phase 3
20
Formaldehyde Approved, Vet_approved 50-00-0 712

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Topical 5% Imiquimod Cream for Vulvar Paget's Disease Active, not recruiting NCT02385188 Phase 3 Imiquimod;paracetamol;lidocaine in Vaseline ointment
2 Evaluation of Trastuzumab In Patients With HER2 Positive Persistent Or Recurrent Vulvar Paget's Disease Withdrawn NCT01427244 Phase 2 trastuzumab
3 Topical Imiquimod in Treating Patients With Recurrent Paget's Disease of the Vulva Completed NCT00504023 Not Applicable imiquimod
4 Collecting Tumor Samples From Patients With Gynecological Tumors Completed NCT00897442
5 Gynecologic Extramammary Paget's Disease Recruiting NCT03564483
6 Evaluation of the Role of Vibrational Spectroscopy in the Assessment of Vulval Disease Suspended NCT02223975

Search NIH Clinical Center for Vulval Paget's Disease

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Genetic Tests for Vulval Paget's Disease

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Anatomical Context for Vulval Paget's Disease

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MalaCards organs/tissues related to Vulval Paget's Disease:

41
Skin
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Publications for Vulval Paget's Disease

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Articles related to Vulval Paget's Disease:

# Title Authors Year
1
Extra Mammary Paget's Disease of Vulva-a Case Report. ( 27872543 )
2016
2
Cervical adenocarcinoma secondary to primary vulval Paget's disease: an unusual form of retrograde spread. ( 25522668 )
2014
3
Vulval Paget's disease associated with ovarian teratoma. ( 15763808 )
2004
4
Successful photodynamic therapy of vulval Paget's disease using a novel patch-based delivery system containing 5-aminolevulinic acid. ( 15383120 )
2004
5
Photodynamic therapy for inoperable vulval Paget's disease using delta-aminolaevulinic acid: successful management of a large skin lesion. ( 10468815 )
1999
6
Endocervical adenocarcinoma and vulval Paget's disease: a significant association. ( 6254556 )
1980
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Variations for Vulval Paget's Disease

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Expression for Vulval Paget's Disease

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Search GEO for disease gene expression data for Vulval Paget's Disease.
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Pathways for Vulval Paget's Disease

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Pathways related to Vulval Paget's Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Bladder cancer 37 1
10.66 CDKN2A ERBB2 UPK3A
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GO Terms for Vulval Paget's Disease

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Biological processes related to Vulval Paget's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of immature T cell proliferation in thymus GO:0033088 8.62 CDKN2A ERBB2
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Sources for Vulval Paget's Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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