MCID: VLV021
MIFTS: 27

Vulval Paget's Disease

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Vulval Paget's Disease

MalaCards integrated aliases for Vulval Paget's Disease:

Name: Vulval Paget's Disease 12 15
Paget's Disease of Vulva 12 71
Vulvar Paget's Disease 12
Vulval Paget Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2097
NCIt 50 C4027
SNOMED-CT 67 254898001
UMLS 71 C1275217

Summaries for Vulval Paget's Disease

Disease Ontology : 12 A vulva adenocarcinoma that is characterized by distinctive large cells with prominent cytoplasm, referred to as Paget cells and is an intraepithelial neoplasm of epithelial origin expressing apocrine or eccrine glandular-like features.

MalaCards based summary : Vulval Paget's Disease, also known as paget's disease of vulva, is related to mammary paget's disease and ureteral benign neoplasm. An important gene associated with Vulval Paget's Disease is KRT7 (Keratin 7). The drugs Acetaminophen and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include breast, skin and cervix.

Related Diseases for Vulval Paget's Disease

Diseases related to Vulval Paget's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 254)
# Related Disease Score Top Affiliating Genes
1 mammary paget's disease 30.5 PIP KRT7 ERBB2
2 ureteral benign neoplasm 30.3 UPK3A KRT7
3 transitional cell carcinoma 30.0 UPK3A KRT7 ERBB2
4 eccrine papillary adenocarcinoma 29.9 PIP KRT7 CEACAM5
5 endocervical carcinoma 29.8 KRT7 ERBB2 CEACAM5
6 endocervical adenocarcinoma 29.8 KRT7 ERBB2 CEACAM5
7 large cell carcinoma 29.8 KRT7 ERBB2 CEACAM5
8 rectum adenocarcinoma 29.7 PIP KRT7 ERBB2 CEACAM5
9 cervical adenocarcinoma 29.6 KRT7 ERBB2 EBAG9 CEACAM5
10 vulvar disease 29.5 PIP KRT7 ERBB2 CEACAM5
11 sweat gland cancer 29.5 PIP KRT7 ERBB2 CEACAM5
12 vulva cancer 29.1 UPK3A PIP KRT7 ERBB2 CEACAM5
13 skin carcinoma 28.8 PIP MLANA KRT7 ERBB2 CEACAM5
14 paget disease, extramammary 28.3 PIP MLANA KRT7 ERBB2 EBAG9 CEACAM5
15 gastric signet ring cell adenocarcinoma 10.2 PIP KRT7
16 ceruminoma 10.2 PIP KRT7
17 ceruminous adenocarcinoma 10.2 PIP KRT7
18 bartholin's gland disease 10.2 PIP KRT7
19 bartholin's gland carcinoma 10.2 PIP KRT7
20 eyelid carcinoma 10.2 PIP KRT7
21 erysipeloid 10.2 PIP KRT7
22 renal pelvis transitional cell carcinoma 10.2 UPK3A KRT7
23 dacryocystocele 10.2 PIP KRT7
24 chronic inflammation of lacrimal passage 10.2 PIP KRT7
25 tinea cruris 10.2 PIP KRT7
26 peritoneal serous adenocarcinoma 10.2 PIP KRT7
27 urethral diverticulum 10.2 UPK3A KRT7
28 papillary cystadenocarcinoma 10.2 PIP KRT7
29 gastric squamous cell carcinoma 10.2 UPK3A KRT7
30 papillary transitional carcinoma 10.2 UPK3A KRT7
31 urachus cancer 10.2 UPK3A PIP
32 syringoma 10.2 KRT7 CEACAM5
33 transitional papilloma 10.2 UPK3A KRT7
34 glandular cystitis 10.2 UPK3A KRT7
35 adenosquamous carcinoma 10.2 KRT7 CEACAM5
36 papillary adenoma 10.2 KRT7 CEACAM5
37 leukoplakia of penis 10.2 KRT7 CEACAM5
38 ovarian brenner tumor 10.2 UPK3A KRT7
39 bladder clear cell adenocarcinoma 10.2 UPK3A KRT7
40 adenocarcinoma 10.2
41 urethral villous adenoma 10.2 KRT7 CEACAM5
42 villous adenoma 10.2 KRT7 CEACAM5
43 ureter adenocarcinoma 10.2 KRT7 CEACAM5
44 mucinous adenofibroma 10.2 KRT7 CEACAM5
45 pancreatic foamy gland adenocarcinoma 10.2 KRT7 CEACAM5
46 eccrine porocarcinoma 10.2 KRT7 CEACAM5
47 pancreatic serous cystadenocarcinoma 10.2 KRT7 CEACAM5
48 urinary bladder villous adenoma 10.2 KRT7 CEACAM5
49 external ear carcinoma 10.2 KRT7 CEACAM5
50 vaginal tubulovillous adenoma 10.2 KRT7 CEACAM5

Graphical network of the top 20 diseases related to Vulval Paget's Disease:



Diseases related to Vulval Paget's Disease

Symptoms & Phenotypes for Vulval Paget's Disease

Drugs & Therapeutics for Vulval Paget's Disease

Drugs for Vulval Paget's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetaminophen Approved Phase 3 103-90-2 1983
2
Lidocaine Approved, Vet_approved Phase 3 137-58-6 3676
3
Petrolatum Approved, Investigational Phase 3 8009-03-8
4
Imiquimod Approved, Investigational Phase 3 99011-02-6 57469
5 Sodium Channel Blockers Phase 3
6 Analgesics, Non-Narcotic Phase 3
7 Anesthetics Phase 3
8 Adjuvants, Immunologic Phase 3
9 Immunologic Factors Phase 3
10 Diuretics, Potassium Sparing Phase 3
11 Analgesics Phase 3
12 Anesthetics, Local Phase 3
13 interferons Phase 3
14 Dermatologic Agents Phase 3
15 Emollients Phase 3
16 Antipyretics Phase 3
17 Anti-Arrhythmia Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Topical 5% Imiquimod Cream for Vulvar Paget's Disease: Clinical Efficacy, Safety and Immunological Response Completed NCT02385188 Phase 3 Imiquimod;paracetamol;lidocaine in Vaseline ointment
2 A Phase II Evaluation of Trastuzumab In Patients With HER2 Positive Persistent Or Recurrent Vulvar Paget's Disease Withdrawn NCT01427244 Phase 2 trastuzumab
3 Analyses of the Outcome of a Treatment of Vulvar Paget Disease Completed NCT03900975

Search NIH Clinical Center for Vulval Paget's Disease

Genetic Tests for Vulval Paget's Disease

Anatomical Context for Vulval Paget's Disease

MalaCards organs/tissues related to Vulval Paget's Disease:

40
Breast, Skin, Cervix

Publications for Vulval Paget's Disease

Articles related to Vulval Paget's Disease:

(show all 21)
# Title Authors PMID Year
1
Invasive Vulval Paget's disease treated with primary radiotherapy: A rare case report and literature review. 61
33251315 2020
2
Invasive cervical adenocarcinoma arising from extension of recurrent vulval Paget's disease. 61
32532900 2020
3
Bladder Carcinoma Presenting as Paget's Disease of Vulva: An Uncommon Entity. 61
30504985 2018
4
Extramammary Paget's disease of vulva: A rare entity. 61
28442808 2017
5
Extra Mammary Paget's Disease of Vulva-a Case Report. 61
27872543 2016
6
Profunda artery perforator based V-Y rotation advancement flap for total vulvectomy defect reconstruction--A case report and literature review. 61
26402576 2015
7
Cervical adenocarcinoma secondary to primary vulval Paget's disease: an unusual form of retrograde spread. 61
25522668 2015
8
Co-existence of extramammary Paget's disease and Bowen's disease of vulva. 61
25382511 2014
9
Premalignant lesions of the lower female genital tract: cervix, vagina and vulva. 61
23442737 2013
10
Paget's disease in an Asian woman. 61
21465983 2011
11
Vulvar and breast Paget's disease with synchronous underlying cancer: a unique association. 61
19112575 2009
12
Reduced E-cadherin expression correlates with disease progression in Paget's disease of the vulva but not Paget's disease of the breast. 61
18469796 2008
13
Vulval Paget's disease associated with ovarian teratoma. 61
15763808 2004
14
Successful photodynamic therapy of vulval Paget's disease using a novel patch-based delivery system containing 5-aminolevulinic acid. 61
15383120 2004
15
Photodynamic therapy for inoperable vulval Paget's disease using delta-aminolaevulinic acid: successful management of a large skin lesion. 61
10468815 1999
16
Paget's disease of the vulva associated with local adenocarcinoma and previous breast adenocarcinoma: report of two cases. 61
10417532 1999
17
Laser ablation of recurrent Paget's disease of vulva and perineum. 61
10150074 1992
18
[Paget's disease of the vulva associated with Paget's disease of the breast. Apropos of a case report. Review of the literature]. 61
6298303 1982
19
Endocervical adenocarcinoma and vulval Paget's disease: a significant association. 61
6254556 1980
20
Paget's disease of vulva. 61
4329788 1971
21
Apocrine-gland adenocarcinoma and extramammary Paget's disease of vulva; review of the literature and report of a case. 61
13199769 1954

Variations for Vulval Paget's Disease

Expression for Vulval Paget's Disease

Search GEO for disease gene expression data for Vulval Paget's Disease.

Pathways for Vulval Paget's Disease

GO Terms for Vulval Paget's Disease

Cellular components related to Vulval Paget's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apical plasma membrane GO:0016324 8.8 UPK3A ERBB2 CEACAM5

Sources for Vulval Paget's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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