Vulvar Adenocarcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: VLV050 MIFTS: 24	Vulvar Adenocarcinoma Categories: Reproductive diseases, Rare diseases, Cancer diseases
Genes Related diseases Publications Pathways Drugs Download Expand all tables

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Aliases & Classifications for Vulvar Adenocarcinoma

MalaCards integrated aliases for Vulvar Adenocarcinoma:

Name: Vulvar Adenocarcinoma ⁵⁹ ⁷³

Adenocarcinoma of the Vulva ⁵⁹

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Reproductive diseases

See all MalaCards categories (disease lists)

Orphanet: ⁵⁹

Rare gynaecological and obstetric diseases

External Ids:

Orphanet ⁵⁹ ORPHA494454

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Summaries for Vulvar Adenocarcinoma

MalaCards based summary : Vulvar Adenocarcinoma, also known as adenocarcinoma of the vulva, is related to adenocarcinoma and vulva adenocarcinoma. An important gene associated with Vulvar Adenocarcinoma is RB1 (RB Transcriptional Corepressor 1), and among its related pathways/superpathways are TNFR1 Pathway and Glioma. The drug Cisplatin has been mentioned in the context of this disorder.

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Related Diseases for Vulvar Adenocarcinoma

Diseases related to Vulvar Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 24)

#	Related Disease	Score	Top Affiliating Genes
1	adenocarcinoma	29.6	RB1 TP53
2	vulva adenocarcinoma	11.5
3	dedifferentiated liposarcoma	9.8	RB1 TP53
4	suppressor of tumorigenicity 3	9.8	RB1 TP53
5	retinal cancer	9.8	RB1 TP53
6	sensory system cancer	9.8	RB1 TP53
7	ocular cancer	9.7	RB1 TP53
8	nervous system cancer	9.7	RB1 TP53
9	gliosarcoma	9.7	RB1 TP53
10	osteogenic sarcoma	9.7	RB1 TP53
11	bladder urothelial carcinoma	9.7	RB1 TP53
12	papilloma	9.7	RB1 TP53
13	small cell cancer of the lung	9.7	RB1 TP53
14	adamantinoma of long bones	9.7	RB1 TP53
15	glioblastoma multiforme	9.6	RB1 TP53
16	retinoblastoma	9.6	RB1 TP53
17	hematologic cancer	9.6	RB1 TP53
18	squamous cell carcinoma, head and neck	9.6	RB1 TP53
19	sarcoma	9.6	RB1 TP53
20	cervical cancer	9.5	RB1 TP53
21	squamous cell carcinoma	9.4	RB1 TP53
22	glioblastoma	9.3	RB1 TP53
23	esophageal cancer	9.2	RB1 TP53
24	bladder cancer	9.0	RB1 TP53

Graphical network of the top 20 diseases related to Vulvar Adenocarcinoma:

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Symptoms & Phenotypes for Vulvar Adenocarcinoma

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Drugs & Therapeutics for Vulvar Adenocarcinoma

Drugs for Vulvar Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Cisplatin

Approved

Phase 1

15663-27-1

84093 441203 2767

Synonyms:

(SP-4-1)-diamminedichloridoplatinum

(SP-4-1)-diamminedichloroplatinum

(SP-4-2)-diamminedichloridoplatinum

(SP-4-2)-diamminedichloroplatinum

Abiplatin

Biocisplatinum

Briplatin

CACP

Carboquone

CDDP

CHEBI:35852

CID441203

Cis Pt II

cis-[PtCl2(NH3)2]

cis-DDP

Cis-DDP

Cis-Diaminedichloroplatinum

cis-diamminedichloridoplatinum(II)

cis-Diamminedichloroplatinum

Cis-Diamminedichloroplatinum

cis-diamminedichloroplatinum(II)

cis-Dichlorodiammineplatinum(II)

Cismaplat

Cisplatine

Cisplatino

Cisplatinum

Cisplatyl

Citoplationo

CPD0-1392

CPDC

CPDD

DB00515

DDP

DDPT

Diamminedichloroplatinum

EU-0100918

Lederplatin

nchembio773-comp1

Neoplatin

Peyrone's chloride

Peyrone's salt

Plastin

Platamine

Platiblastin

Platidiam

Platinex

Platinol

Platinol-AQ

Platinoxan

Platinum Ammine Chloride

Platinum Ammonium Chloride

Platinum Diamine Dichloride

Randa

trans-DDP

Trans-DDP

Trans-Diaminedichloroplatinum

trans-diamminedichloridoplatinum(II)

Trans-Diamminedichloroplatinum

Trans-Dichlorodiammine Platinum

Trans-Platinumdiammine Dichloride

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Triapine With Chemotherapy and Radiation Therapy in Treating Patients With IB2-IVA Cervical or Vulvar Cancer	Suspended	NCT02595879	Phase 1	Cisplatin;Triapine

Search NIH Clinical Center for Vulvar Adenocarcinoma

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Genetic Tests for Vulvar Adenocarcinoma

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Anatomical Context for Vulvar Adenocarcinoma

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Publications for Vulvar Adenocarcinoma

Articles related to Vulvar Adenocarcinoma:

(show all 11)

#	Title	Authors	Year
1	Vulvar Adenocarcinoma With Neuroendocrine Differentiation: A Case Report. ( 28157827 )	Gabrilovich S....Heller D.S.	2017
2	FDG-PET/CT of Vulvar Adenocarcinoma With Diffuse Metastases. ( 27187733 )	Patel D....Lu Y.	2016
3	Vulvar adenocarcinoma: visual resemblance to a vulvar abscess. ( 23761517 )	Pandey K.C....Pant N.K.	2013
4	An unexpected complete remission of advanced intestinal-type vulvar adenocarcinoma after neoadjuvant chemotherapy: a case report and a literature review. ( 24307962 )	Musella A....Panici P.B.	2013
5	Skull metastasis in primary vulvar adenocarcinoma of the Bartholin's gland: a case report. ( 15936060 )	Ferrandina G....Scambia G.	2005
6	Liposomal doxorubicin for treatment of metastatic chemorefractory vulvar adenocarcinoma. ( 12468332 )	Huang G.S....Teng N.N.	2002
7	Primary vulvar adenocarcinoma of cloacogenic origin. ( 11531187 )	Zaidi S.N....Conner M.G.	2001
8	Radiotherapy with concurrent chemotherapy for vulvar adenocarcinoma associated with extramammary Paget's disease. ( 11161871 )	Yamamoto R....Fujimoto S.	2001
9	Paget's disease of the vulva: prevalence of associated vulvar adenocarcinoma, invasive Paget's disease, and recurrence after surgical excision. ( 9914572 )	Fanning J....Schuerch C.	1999
10	Cutaneous metastasis from vulvar adenocarcinoma. ( 8002143 )	Prignano F....Difonzo E.M.	1994
11	Vulvar adenocarcinoma of apocrine gland (Paget's disease of the vulva). Report of a patient. ( 14426499 )	Nelson W.W.	1960

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Genes for Vulvar Adenocarcinoma

Genes related to Vulvar Adenocarcinoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	RB1	RB Transcriptional Corepressor 1	Protein Coding	17.32	GeneCards inferred via : Variants (show sections)
2	TP53	Tumor Protein P53	Protein Coding	17.32	GeneCards inferred via : Variants (show sections)

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Variations for Vulvar Adenocarcinoma

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Expression for Vulvar Adenocarcinoma

Search GEO for disease gene expression data for Vulvar Adenocarcinoma.

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Pathways for Vulvar Adenocarcinoma

Pathways related to Vulvar Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 32)

#	Super pathways	Score	Top Affiliating Genes
1	TNFR1 Pathway ⁶⁴ Show member pathways Apoptosis and survival TNFR1 signaling pathway ²² Apoptosis through Death Receptors ⁶⁴ Apoptotic Pathways Triggered By HIV1 ⁶⁴ DR3 Signaling ⁶⁴ Fas Signaling ⁶⁴ GITR Pathway ⁶⁴ HIV-1 Nef- Negative effector of Fas and TNF-alpha ¹ Stimulation of the cell death response by PAK-2p34 ⁶⁶ TNF alpha Signaling Pathway ¹ TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway ¹ TNF Signaling ⁶⁴ TRAIL Pathway ⁶⁴ TWEAK Pathway ⁶⁴	12.44	RB1 TP53
2	Glioma ³⁷ Show member pathways EGFR tyrosine kinase inhibitor resistance ³⁷ Endocrine resistance ³⁷ Melanoma ³⁷ Non-small cell lung cancer ³⁷ Signaling Pathways in Glioblastoma ¹	12.32	RB1 TP53
3	Gastric cancer ³⁷ Show member pathways Breast cancer ³⁷ Hepatocellular carcinoma ³⁷	12.31	RB1 TP53
4	Chks in Checkpoint Regulation ⁶⁴ Show member pathways DNA Repair Mechanisms ⁶⁴ Estrogen-mediated S-Phase Entry ⁶⁴ G2-M Phase Transition ⁶⁴ Parkinson's Disease Pathway ⁶⁴ SREBP Proteolysis ⁶⁴	12.25	RB1 TP53
5	4-1BB Pathway ⁶⁴ Show member pathways CD27 Pathway ⁶⁴ CD40 Signaling ⁶⁴ CMV and MAPK Pathways ⁶⁴ NF-KappaB Activation by EBV ⁶⁴ NF-kappaB Activation by Viruses ⁶⁴ PKR Pathway ⁶⁴ SUMO Pathway ⁶⁴ TNFR2 Pathway ⁶⁴	12.24	RB1 TP53
6	Kaposi's sarcoma-associated herpesvirus infection ³⁷ Show member pathways Hepatitis B ³⁷	12.15	RB1 TP53
7	Mitotic G1-G1/S phases ⁶⁶ Show member pathways G1 to S cell cycle control ¹ G1/S Transition ⁶⁶	12.14	RB1 TP53
8	Development EGFR signaling pathway ²² Show member pathways Development ERBB-family signaling ²² EGF Pathway ⁶⁴ EGFR Signaling Pathway ⁶⁷ ErbB receptor signaling network ¹	12.1	RB1 TP53
9	DNA Damage ⁴	12.08	RB1 TP53
10	HTLV-I infection ³⁷	12.01	RB1 TP53
11	DNA Damage Response ¹ Show member pathways miRNA Regulation of DNA Damage Response ¹ p53 signaling pathway ³⁷	11.97	RB1 TP53
12	Cell cycle ¹ ³⁷	11.95	RB1 TP53
13	Cyclins and Cell Cycle Regulation ⁶⁴ Show member pathways Cell Cycle Control by BTG Proteins ⁶⁴ Cyclin D associated events in G1 ⁶⁶ G1 Phase ⁶⁶ G1-S Phase Transition ⁶⁴ Phosphorylation of proteins involved in G1/S transition by active Cyclin E-Cdk2 complexes ⁶⁶	11.93	RB1 TP53
14	DNA Damage/Telomere Stress Induced Senescence ⁶⁶ Show member pathways Formation of Senescence-Associated Heterochromatin Foci (SAHF) ⁶⁶ Packaging Of Telomere Ends ⁶⁶ Signal transduction Activin A signaling regulation ²²	11.92	RB1 TP53
15	Epstein-Barr virus infection ³⁷	11.87	RB1 TP53
16	Viral carcinogenesis ³⁷	11.86	RB1 TP53
17	p53 Signaling ⁶⁴ Show member pathways p53 Pathway ⁶⁷	11.82	RB1 TP53
18	Cellular senescence (KEGG) ³⁷	11.73	RB1 TP53
19	Integrated Breast Cancer Pathway ¹	11.7	RB1 TP53
20	SMAD Signaling Network ⁶⁴	11.62	RB1 TP53
21	Direct p53 effectors ¹	11.62	RB1 TP53
22	Cell cycle Cell cycle (generic schema) ²² Show member pathways Cell cycle Regulation of G1/S transition (part 2) ²² G0 and Early G1 ⁶⁶ G2 Phase ⁶⁶	11.56	RB1 TP53
23	Spinal Cord Injury ¹	11.56	RB1 TP53
24	Glioblastoma Multiforme ⁶⁴	11.5	RB1 TP53
25	Senescence and Autophagy in Cancer ¹	11.46	RB1 TP53
26	Small cell lung cancer ³⁷	11.37	RB1 TP53
27	Retinoblastoma (RB) in Cancer ¹	11.31	RB1 TP53
28	BRCA1 Pathway ⁶⁴ Show member pathways Fanconi's Anaemia Pathway ⁶⁴	11.24	RB1 TP53
29	Bladder cancer ³⁷ ¹	11.12	RB1 TP53
30	Photodynamic therapy-induced AP-1 survival signaling. ¹	10.86	RB1 TP53
31	Integrated Cancer Pathway ¹	10.62	RB1 TP53
32	Inhibition of Ribosome Biogenesis by p14(ARF) ⁶⁴	9.97	RB1 TP53

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GO Terms for Vulvar Adenocarcinoma

Cellular components related to Vulvar Adenocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	PML body	GO:0016605	8.62	RB1 TP53

Biological processes related to Vulvar Adenocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	viral process	GO:0016032	9.26	RB1 TP53
2	negative regulation of cell proliferation	GO:0008285	9.16	RB1 TP53
3	cell cycle arrest	GO:0007050	8.96	RB1 TP53
4	Ras protein signal transduction	GO:0007265	8.62	RB1 TP53

Molecular functions related to Vulvar Adenocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	enzyme binding	GO:0019899	9.26	RB1 TP53
2	transcription factor binding	GO:0008134	9.16	RB1 TP53
3	ubiquitin protein ligase binding	GO:0031625	8.96	RB1 TP53
4	disordered domain specific binding	GO:0097718	8.62	RB1 TP53

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Sources for Vulvar Adenocarcinoma

¹ BioSystems

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³ CDC

⁴ Cell Signaling Technology

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²⁵ Genetics Home Reference

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³⁵ ICD9CM

³⁶ IUPHAR

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⁷¹ TGDB

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⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia