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MCID: VLV050
MIFTS: 26

Vulvar Adenocarcinoma

Categories: Cancer diseases, Rare diseases, Reproductive diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Vulvar Adenocarcinoma

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MalaCards integrated aliases for Vulvar Adenocarcinoma:

Name: Vulvar Adenocarcinoma 58 71
Adenocarcinoma of the Vulva 58

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)
Orphanet: 58  
Rare gynaecological and obstetric diseases


External Ids:

Orphanet 58 ORPHA494454
UMLS 71 C1336975
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Summaries for Vulvar Adenocarcinoma

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MalaCards based summary : Vulvar Adenocarcinoma, also known as adenocarcinoma of the vulva, is related to adenocarcinoma and vulva adenocarcinoma. An important gene associated with Vulvar Adenocarcinoma is RB1 (RB Transcriptional Corepressor 1), and among its related pathways/superpathways are Chks in Checkpoint Regulation and Glioma. Affiliated tissues include lymph node, breast and colon.

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Related Diseases for Vulvar Adenocarcinoma

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Diseases related to Vulvar Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Related Disease Score Top Affiliating Genes
1 adenocarcinoma 29.6 TP53 RB1
2 vulva adenocarcinoma 11.3
3 mucinous adenocarcinoma 10.3
4 appendix adenocarcinoma 10.3
5 endometriosis 10.2
6 clear cell adenocarcinoma 10.2
7 apocrine adenocarcinoma 10.2
8 mammary paget's disease 10.1
9 eccrine adenocarcinoma 10.1
10 vulva cancer 10.0
11 paget disease, extramammary 10.0
12 adenoid cystic carcinoma 10.0
13 endometriosis of ovary 10.0
14 malignant acrospiroma 10.0
15 eccrine papillary adenocarcinoma 10.0
16 vulvar apocrine adenocarcinoma 10.0
17 cloacogenic carcinoma 10.0
18 polymorphous low-grade adenocarcinoma 10.0
19 conjunctival squamous cell carcinoma 9.9 TP53 RB1
20 suppressor of tumorigenicity 3 9.9 TP53 RB1
21 familial retinoblastoma 9.9 TP53 RB1
22 uterus carcinoma in situ 9.9 TP53 RB1
23 cervix uteri carcinoma in situ 9.9 TP53 RB1
24 anogenital venereal wart 9.9 TP53 RB1
25 chromosome 13q14 deletion syndrome 9.9 TP53 RB1
26 gliomatosis cerebri 9.8 TP53 RB1
27 lung oat cell carcinoma 9.8 TP53 RB1
28 penile disease 9.8 TP53 RB1
29 rare tumor 9.8
30 lip and oral cavity cancer 9.8 TP53 RB1
31 lung benign neoplasm 9.8 TP53 RB1
32 penile cancer 9.8 TP53 RB1
33 bone osteosarcoma 9.8 TP53 RB1
34 merkel cell carcinoma 9.8 TP53 RB1
35 dedifferentiated liposarcoma 9.8 TP53 RB1
36 liposarcoma 9.8 TP53 RB1
37 inflammatory myofibroblastic tumor 9.8 TP53 RB1
38 retinal cancer 9.8 TP53 RB1
39 leiomyosarcoma 9.8 TP53 RB1
40 small cell cancer of the lung 9.8 TP53 RB1
41 ocular cancer 9.8 TP53 RB1
42 li-fraumeni syndrome 9.8 TP53 RB1
43 anaplastic astrocytoma 9.8 TP53 RB1
44 tongue carcinoma 9.8 TP53 RB1
45 gliosarcoma 9.8 TP53 RB1
46 papilloma 9.8 TP53 RB1
47 chronic myelomonocytic leukemia 9.8 TP53 RB1
48 bone cancer 9.8 TP53 RB1
49 nervous system cancer 9.8 TP53 RB1
50 mantle cell lymphoma 9.8 TP53 RB1

Graphical network of the top 20 diseases related to Vulvar Adenocarcinoma:



Diseases related to Vulvar Adenocarcinoma
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Symptoms & Phenotypes for Vulvar Adenocarcinoma

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Drugs & Therapeutics for Vulvar Adenocarcinoma

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Search Clinical Trials , NIH Clinical Center for Vulvar Adenocarcinoma

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Genetic Tests for Vulvar Adenocarcinoma

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Anatomical Context for Vulvar Adenocarcinoma

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MalaCards organs/tissues related to Vulvar Adenocarcinoma:

40
Lymph Node, Breast, Colon, Appendix
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Publications for Vulvar Adenocarcinoma

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Articles related to Vulvar Adenocarcinoma:

(show top 50) (show all 63)
# Title Authors PMID Year
1
Clinical characteristics and risk factors of invasion in extramammary Paget's disease of the vulva. 61
32990781 2021
2
Primary adenocarcinomas of the vulva and related structures: An enigmatic and diverse group of tumorsāœ°. 61
33032903 2021
3
Primary invasive lobular carcinoma arising in mammary-like glands of the vulva managed with neoadjuvant trastuzumab-based chemotherapy, excision, and sentinel lymph node biopsy. 61
33489145 2021
4
Treatment of invasive Paget's disease of the vulva in pregnancy: A case report. 61
32671169 2020
5
High Risk of Proximal and Local Neoplasms in 2206 Patients With Anogenital Extramammary Paget's Disease. 61
31567917 2019
6
Primary Clear Cell Adenocarcinoma of the Vulva: A Case Study With Mutation Analysis and Literature Review. 61
31104528 2019
7
Intestinal-type adenocarcinoma of the vulva: A case study. 61
31061870 2019
8
Adenocarcinoma of intestinal type of the vulva. 61
31149555 2019
9
Cloacogenic Adenocarcinoma of the Vulva: A Case Report and Review of the Literature. 61
28272666 2018
10
Detection and genomic characterization of a mammary-like adenocarcinoma. 61
28877932 2017
11
Molecular subtyping of mammary-like adenocarcinoma of the vulva shows molecular similarity to breast carcinomas. 61
28418164 2017
12
Primary mucinous adenocarcinoma of the vulva, intestinal type. 61
28791269 2017
13
Vulvar Adenocarcinoma With Neuroendocrine Differentiation: A Case Report. 61
28157827 2017
14
Cloacogenic adenocarcinoma of the vulva: one new case and literature review. 61
29953800 2017
15
Primary Villoglandular Mucinous Adenocarcinoma of the Vulva. 61
28503335 2017
16
FDG-PET/CT of Vulvar Adenocarcinoma With Diffuse Metastases. 61
27187733 2016
17
Primary mucinous adenocarcinoma of the vulva: A case report and review of the literature. 61
27073659 2016
18
Vulvar mucinous adenocarcinoma with neuroendocrine differentiation: A case report and review of the literature. 61
26861721 2016
19
Apocrine Adenocarcinoma of the Vulva: A Case Report and Review of the Literature. 61
27668109 2016
20
Apocrine carcinoma of the vulva. Case report and review of literature. 61
29787019 2016
21
An unusual case of mammary gland-like carcinoma of vulva: case report and review of literature. 61
26189264 2015
22
Metachronous metastasis from the right colon adenocarcinoma to the vulva: an unusual report and literature review. 61
25755809 2015
23
Recurrence of carcinoma of appendix presenting as vulvar swelling: a case report. 61
25375304 2014
24
Mammary-like adenocarcinoma of the vulva associated to Paget's disease: a case report. 61
25848451 2014
25
Vulvar adenocarcinoma: visual resemblance to a vulvar abscess. 61
23761517 2013
26
Apocrine adenocarcinoma of the vulva. 61
24179652 2013
27
An unexpected complete remission of advanced intestinal-type vulvar adenocarcinoma after neoadjuvant chemotherapy: a case report and a literature review. 61
24307962 2013
28
Primary breast adenocarcinoma in ectopic breast tissue in the vulva. 61
24066246 2013
29
Metastatic adenocarcinoma of mammary-like glands of the vulva successfully treated with surgery and hormonal therapy. 61
22764738 2013
30
Anogenital sweat gland adenocarcinoma of the vulva: a diagnostic conundrum. 61
22407069 2012
31
Primary adnexal adenocarcinoma of the vulva: A diagnosis of exclusion based on location, immunohistochemistry, and pattern of spread. 61
24371661 2012
32
"Intestinal-type" mucinous adenocarcinoma of the vulva: a report of two cases. 61
23091907 2012
33
Collision tumor composed of mammary-type myofibroblastoma and eccrine adenocarcinoma of the vulva. 61
21355955 2011
34
Extramammary Paget's disease: Summary of current knowledge. 61
20883922 2010
35
Shedding of epidermal growth factor receptor is a regulated process that occurs with overexpression in malignant cells. 61
18687326 2008
36
[Paget's disease of the vulva: interest of sentinel lymph node analysis]. 61
16854611 2006
37
The role of radiation therapy for the extramammary paget's disease of the vulva ; experience of 3 cases. 61
19956374 2005
38
Skull metastasis in primary vulvar adenocarcinoma of the Bartholin's gland: a case report. 61
15936060 2005
39
Primary adenocarcinoma of the vulva with an unusual histological pattern. 61
15205982 2004
40
Cloacogenic adenocarcinoma of the vulva presenting as recurrent Bartholin's gland infection. 61
12684613 2003
41
Polymorphous low-grade adenocarcinoma of the vulva and vagina: a tumor resembling adenoid cystic carcinoma. 61
12598921 2003
42
Liposomal doxorubicin for treatment of metastatic chemorefractory vulvar adenocarcinoma. 61
12468332 2002
43
The role of p53 and Ki67 in Paget's disease of the vulva and the breast. 61
12144821 2002
44
Villoglandular adenocarcinoma of the vulva. 61
11606106 2001
45
Primary vulvar adenocarcinoma of cloacogenic origin. 61
11531187 2001
46
Radiotherapy with concurrent chemotherapy for vulvar adenocarcinoma associated with extramammary Paget's disease. 61
11161871 2001
47
Clear cell adenocarcinoma of the vulva arising in endometriosis. A case report. 61
11055499 2000
48
Cloacogenic adenocarcinoma of the vulva. 61
10419750 1999
49
Paget's disease of the vulva: prevalence of associated vulvar adenocarcinoma, invasive Paget's disease, and recurrence after surgical excision. 61
9914572 1999
50
Primary neuroendocrine differentiated mucinous adenocarcinoma of the vulva: case report and review of the literature. 61
9677464 1998
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Variations for Vulvar Adenocarcinoma

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Expression for Vulvar Adenocarcinoma

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Search GEO for disease gene expression data for Vulvar Adenocarcinoma.
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Pathways for Vulvar Adenocarcinoma

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Pathways related to Vulvar Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 29)
# Super pathways Score Top Affiliating Genes
1
Chks in Checkpoint Regulation 63
Show member pathways
 12.25 TP53 RB1
2
Glioma 36
Show member pathways
 12.24 TP53 RB1
3
4-1BB Pathway 63
Show member pathways
 12.23 TP53 RB1
4
Mitotic G1-G1/S phases 65
Show member pathways
 12.14 TP53 RB1
5
DNA Damage 4
12.08 TP53 RB1
6
WNT Signaling 63
12 TP53 RB1
7
DNA Damage Response 1
Show member pathways
 11.97 TP53 RB1
8
Cell cycle 36 1
11.95 TP53 RB1
9
Cyclins and Cell Cycle Regulation 63
Show member pathways
 11.93 TP53 RB1
10
DNA Damage/Telomere Stress Induced Senescence 65
Show member pathways
 11.92 TP53 RB1
11
Human T-cell leukemia virus 1 infection 36
11.91 TP53 RB1
12
Viral carcinogenesis 36
11.87 TP53 RB1
13
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 11.84 TP53 RB1
14
p53 Signaling 63
Show member pathways
 11.82 TP53 RB1
15
MAPK Signaling: Mitogen Stimulation Pathway 64
Show member pathways
 11.8 TP53 RB1
16
Cellular senescence (KEGG) 36
11.72 TP53 RB1
17
Integrated Breast Cancer Pathway 1
11.7 TP53 RB1
18
Direct p53 effectors 1
11.62 TP53 RB1
19
Spinal Cord Injury 1
11.56 TP53 RB1
20
Glioblastoma Multiforme 63
11.5 TP53 RB1
21
Senescence and Autophagy in Cancer 1
11.46 TP53 RB1
22
Small cell lung cancer 36
11.37 TP53 RB1
23
Retinoblastoma (RB) in Cancer 1
11.31 TP53 RB1
24
Transcription_P53 signaling pathway 23
11.27 TP53 RB1
25
BRCA1 Pathway 63
Show member pathways
 11.24 TP53 RB1
26
Bladder cancer 36 1
11.12 TP53 RB1
27
Photodynamic therapy-induced AP-1 survival signaling. 1
10.86 TP53 RB1
28
Integrated Cancer Pathway 1
10.62 TP53 RB1
29
Inhibition of Ribosome Biogenesis by p14(ARF) 63
9.97 TP53 RB1
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GO Terms for Vulvar Adenocarcinoma

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Cellular components related to Vulvar Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor complex GO:0005667 8.96 TP53 RB1
2 PML body GO:0016605 8.62 TP53 RB1

Biological processes related to Vulvar Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.4 TP53 RB1
2 regulation of cell cycle GO:0051726 9.37 TP53 RB1
3 cell cycle arrest GO:0007050 9.32 TP53 RB1
4 negative regulation of cell growth GO:0030308 9.26 TP53 RB1
5 Ras protein signal transduction GO:0007265 9.16 TP53 RB1
6 neuron apoptotic process GO:0051402 8.96 TP53 RB1
7 negative regulation of mitotic cell cycle GO:0045930 8.62 TP53 RB1

Molecular functions related to Vulvar Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.32 TP53 RB1
2 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 9.26 TP53 RB1
3 transcription factor binding GO:0008134 9.16 TP53 RB1
4 ubiquitin protein ligase binding GO:0031625 8.96 TP53 RB1
5 disordered domain specific binding GO:0097718 8.62 TP53 RB1
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Sources for Vulvar Adenocarcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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