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MCID: VLV050
MIFTS: 26

Vulvar Adenocarcinoma

Categories: Cancer diseases, Rare diseases, Reproductive diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Vulvar Adenocarcinoma

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MalaCards integrated aliases for Vulvar Adenocarcinoma:

Name: Vulvar Adenocarcinoma 58 71
Adenocarcinoma of the Vulva 58

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)
Orphanet: 58  
Rare gynaecological and obstetric diseases


External Ids:

Orphanet 58 ORPHA494454
UMLS 71 C1336975
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Summaries for Vulvar Adenocarcinoma

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MalaCards based summary : Vulvar Adenocarcinoma, also known as adenocarcinoma of the vulva, is related to vulva adenocarcinoma and adenocarcinoma. An important gene associated with Vulvar Adenocarcinoma is RB1 (RB Transcriptional Corepressor 1), and among its related pathways/superpathways are Glioma and 4-1BB Pathway. Affiliated tissues include breast, appendix and lung.

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Related Diseases for Vulvar Adenocarcinoma

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Diseases related to Vulvar Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Related Disease Score Top Affiliating Genes
1 vulva adenocarcinoma 11.4
2 adenocarcinoma 10.4
3 mucinous adenocarcinoma 10.2
4 appendix adenocarcinoma 10.2
5 mammary paget's disease 10.2
6 endometriosis 10.1
7 clear cell adenocarcinoma 10.1
8 apocrine adenocarcinoma 10.1
9 vulva cancer 10.0
10 eccrine adenocarcinoma 10.0
11 rare tumor 9.9
12 breast cancer 9.9
13 paget disease, extramammary 9.9
14 villous adenoma 9.9
15 adenoid cystic carcinoma 9.9
16 endometriosis of ovary 9.9
17 malignant acrospiroma 9.9
18 eccrine papillary adenocarcinoma 9.9
19 vulvar apocrine adenocarcinoma 9.9
20 cloacogenic carcinoma 9.9
21 polymorphous low-grade adenocarcinoma 9.9
22 suppressor of tumorigenicity 3 9.8 TP53 RB1
23 conjunctival squamous cell carcinoma 9.8 TP53 RB1
24 dedifferentiated liposarcoma 9.8 TP53 RB1
25 liposarcoma 9.8 TP53 RB1
26 familial retinoblastoma 9.8 TP53 RB1
27 uterus carcinoma in situ 9.8 TP53 RB1
28 cervix uteri carcinoma in situ 9.8 TP53 RB1
29 anogenital venereal wart 9.8 TP53 RB1
30 gliomatosis cerebri 9.7 TP53 RB1
31 penile disease 9.7 TP53 RB1
32 lung benign neoplasm 9.7 TP53 RB1
33 epidermodysplasia verruciformis 1 9.7 TP53 RB1
34 merkel cell carcinoma 9.7 TP53 RB1
35 inflammatory myofibroblastic tumor 9.7 TP53 RB1
36 retinal cancer 9.7 TP53 RB1
37 leiomyosarcoma 9.7 TP53 RB1
38 small cell cancer of the lung 9.7 TP53 RB1
39 grade iii astrocytoma 9.7 TP53 RB1
40 uterine carcinosarcoma 9.7 TP53 RB1
41 ocular cancer 9.7 TP53 RB1
42 li-fraumeni syndrome 9.7 TP53 RB1
43 gliosarcoma 9.7 TP53 RB1
44 bone cancer 9.7 TP53 RB1
45 papilloma 9.6 TP53 RB1
46 melanoma, cutaneous malignant 1 9.6 TP53 RB1
47 nervous system cancer 9.6 TP53 RB1
48 mantle cell lymphoma 9.6 TP53 RB1
49 breast adenocarcinoma 9.6 TP53 RB1
50 osteogenic sarcoma 9.5 TP53 RB1

Graphical network of the top 20 diseases related to Vulvar Adenocarcinoma:



Diseases related to Vulvar Adenocarcinoma
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Symptoms & Phenotypes for Vulvar Adenocarcinoma

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Drugs & Therapeutics for Vulvar Adenocarcinoma

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Search Clinical Trials , NIH Clinical Center for Vulvar Adenocarcinoma

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Genetic Tests for Vulvar Adenocarcinoma

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Anatomical Context for Vulvar Adenocarcinoma

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MalaCards organs/tissues related to Vulvar Adenocarcinoma:

40
Breast, Appendix, Lung, Lymph Node, Colon, Bone, Ovary
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Publications for Vulvar Adenocarcinoma

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Articles related to Vulvar Adenocarcinoma:

(show top 50) (show all 59)
# Title Authors PMID Year
1
High Risk of Proximal and Local Neoplasms in 2206 Patients With Anogenital Extramammary Paget's Disease. 61
31567917 2019
2
Primary Clear Cell Adenocarcinoma of the Vulva: A Case Study With Mutation Analysis and Literature Review. 61
31104528 2019
3
Intestinal-type adenocarcinoma of the vulva: A case study. 61
31061870 2019
4
Adenocarcinoma of intestinal type of the vulva. 61
31149555 2019
5
Cloacogenic Adenocarcinoma of the Vulva: A Case Report and Review of the Literature. 61
28272666 2018
6
Detection and genomic characterization of a mammary-like adenocarcinoma. 61
28877932 2017
7
Molecular subtyping of mammary-like adenocarcinoma of the vulva shows molecular similarity to breast carcinomas. 61
28418164 2017
8
Primary mucinous adenocarcinoma of the vulva, intestinal type. 61
28791269 2017
9
Vulvar Adenocarcinoma With Neuroendocrine Differentiation: A Case Report. 61
28157827 2017
10
Primary Villoglandular Mucinous Adenocarcinoma of the Vulva. 61
28503335 2017
11
Cloacogenic adenocarcinoma of the vulva: one new case and literature review. 61
29953800 2017
12
FDG-PET/CT of Vulvar Adenocarcinoma With Diffuse Metastases. 61
27187733 2016
13
Primary mucinous adenocarcinoma of the vulva: A case report and review of the literature. 61
27073659 2016
14
Vulvar mucinous adenocarcinoma with neuroendocrine differentiation: A case report and review of the literature. 61
26861721 2016
15
Apocrine Adenocarcinoma of the Vulva: A Case Report and Review of the Literature. 61
27668109 2016
16
Apocrine carcinoma of the vulva. Case report and review of literature. 61
29787019 2016
17
An unusual case of mammary gland-like carcinoma of vulva: case report and review of literature. 61
26189264 2015
18
Metachronous metastasis from the right colon adenocarcinoma to the vulva: an unusual report and literature review. 61
25755809 2015
19
Recurrence of carcinoma of appendix presenting as vulvar swelling: a case report. 61
25375304 2014
20
Mammary-like adenocarcinoma of the vulva associated to Paget's disease: a case report. 61
25848451 2014
21
Vulvar adenocarcinoma: visual resemblance to a vulvar abscess. 61
23761517 2013
22
Metastatic adenocarcinoma of mammary-like glands of the vulva successfully treated with surgery and hormonal therapy. 61
22764738 2013
23
Primary breast adenocarcinoma in ectopic breast tissue in the vulva. 61
24066246 2013
24
Apocrine adenocarcinoma of the vulva. 61
24179652 2013
25
An unexpected complete remission of advanced intestinal-type vulvar adenocarcinoma after neoadjuvant chemotherapy: a case report and a literature review. 61
24307962 2013
26
Anogenital sweat gland adenocarcinoma of the vulva: a diagnostic conundrum. 61
22407069 2012
27
"Intestinal-type" mucinous adenocarcinoma of the vulva: a report of two cases. 61
23091907 2012
28
Primary adnexal adenocarcinoma of the vulva: A diagnosis of exclusion based on location, immunohistochemistry, and pattern of spread. 61
24371661 2012
29
Collision tumor composed of mammary-type myofibroblastoma and eccrine adenocarcinoma of the vulva. 61
21355955 2011
30
Extramammary Paget's disease: Summary of current knowledge. 61
20883922 2010
31
Shedding of epidermal growth factor receptor is a regulated process that occurs with overexpression in malignant cells. 61
18687326 2008
32
[Paget's disease of the vulva: interest of sentinel lymph node analysis]. 61
16854611 2006
33
The role of radiation therapy for the extramammary paget's disease of the vulva ; experience of 3 cases. 61
19956374 2005
34
Skull metastasis in primary vulvar adenocarcinoma of the Bartholin's gland: a case report. 61
15936060 2005
35
Primary adenocarcinoma of the vulva with an unusual histological pattern. 61
15205982 2004
36
Polymorphous low-grade adenocarcinoma of the vulva and vagina: a tumor resembling adenoid cystic carcinoma. 61
12598921 2003
37
Cloacogenic adenocarcinoma of the vulva presenting as recurrent Bartholin's gland infection. 61
12684613 2003
38
Liposomal doxorubicin for treatment of metastatic chemorefractory vulvar adenocarcinoma. 61
12468332 2002
39
The role of p53 and Ki67 in Paget's disease of the vulva and the breast. 61
12144821 2002
40
Villoglandular adenocarcinoma of the vulva. 61
11606106 2001
41
Primary vulvar adenocarcinoma of cloacogenic origin. 61
11531187 2001
42
Radiotherapy with concurrent chemotherapy for vulvar adenocarcinoma associated with extramammary Paget's disease. 61
11161871 2001
43
Clear cell adenocarcinoma of the vulva arising in endometriosis. A case report. 61
11055499 2000
44
Cloacogenic adenocarcinoma of the vulva. 61
10419750 1999
45
Paget's disease of the vulva: prevalence of associated vulvar adenocarcinoma, invasive Paget's disease, and recurrence after surgical excision. 61
9914572 1999
46
Primary neuroendocrine differentiated mucinous adenocarcinoma of the vulva: case report and review of the literature. 61
9677464 1998
47
Cutaneous metastasis from vulvar adenocarcinoma. 61
8002143 1994
48
Adenocarcinoma of the mammary-like glands of the vulva: a concept unifying sweat gland carcinoma of the vulva, carcinoma of supernumerary mammary glands and extramammary Paget's disease. 61
8040464 1994
49
Primary adenocarcinoma of the vulva, possibly cloacogenic. A report of two cases. 61
8445601 1993
50
Immunohistochemical stains in extramammary Paget's disease. 61
1384380 1992
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Variations for Vulvar Adenocarcinoma

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Expression for Vulvar Adenocarcinoma

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Search GEO for disease gene expression data for Vulvar Adenocarcinoma.
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Pathways for Vulvar Adenocarcinoma

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Pathways related to Vulvar Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 28)
# Super pathways Score Top Affiliating Genes
1
Glioma 36
Show member pathways
 12.23 TP53 RB1
2
4-1BB Pathway 63
Show member pathways
 12.23 TP53 RB1
3
Mitotic G1-G1/S phases 65
Show member pathways
 12.14 TP53 RB1
4
DNA Damage 4
12.08 TP53 RB1
5
WNT Signaling 63
12 TP53 RB1
6
DNA Damage Response 1
Show member pathways
 11.97 TP53 RB1
7
Cell cycle 1 36
11.95 TP53 RB1
8
Cyclins and Cell Cycle Regulation 63
Show member pathways
 11.93 TP53 RB1
9
DNA Damage/Telomere Stress Induced Senescence 65
Show member pathways
 11.92 TP53 RB1
10
Human T-cell leukemia virus 1 infection 36
11.91 TP53 RB1
11
Viral carcinogenesis 36
11.86 TP53 RB1
12
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 11.84 TP53 RB1
13
p53 Signaling 63
Show member pathways
 11.82 TP53 RB1
14
MAPK Signaling: Mitogen Stimulation Pathway 64
Show member pathways
 11.8 TP53 RB1
15
Cellular senescence (KEGG) 36
11.73 TP53 RB1
16
Integrated Breast Cancer Pathway 1
11.7 TP53 RB1
17
Direct p53 effectors 1
11.62 TP53 RB1
18
Spinal Cord Injury 1
11.56 TP53 RB1
19
Glioblastoma Multiforme 63
11.5 TP53 RB1
20
Senescence and Autophagy in Cancer 1
11.46 TP53 RB1
21
Small cell lung cancer 36
11.37 TP53 RB1
22
Retinoblastoma (RB) in Cancer 1
11.31 TP53 RB1
23
Transcription_P53 signaling pathway 22
11.27 TP53 RB1
24
BRCA1 Pathway 63
Show member pathways
 11.24 TP53 RB1
25
Bladder cancer 36 1
11.12 TP53 RB1
26
Photodynamic therapy-induced AP-1 survival signaling. 1
10.86 TP53 RB1
27
Integrated Cancer Pathway 1
10.62 TP53 RB1
28
Inhibition of Ribosome Biogenesis by p14(ARF) 63
9.97 TP53 RB1
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GO Terms for Vulvar Adenocarcinoma

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Cellular components related to Vulvar Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor complex GO:0005667 8.96 TP53 RB1
2 PML body GO:0016605 8.62 TP53 RB1

Biological processes related to Vulvar Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.37 TP53 RB1
2 regulation of cell cycle GO:0051726 9.32 TP53 RB1
3 cell cycle arrest GO:0007050 9.26 TP53 RB1
4 Ras protein signal transduction GO:0007265 9.16 TP53 RB1
5 neuron apoptotic process GO:0051402 8.96 TP53 RB1
6 negative regulation of mitotic cell cycle GO:0045930 8.62 TP53 RB1

Molecular functions related to Vulvar Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.32 TP53 RB1
2 transcription factor binding GO:0008134 9.26 TP53 RB1
3 ubiquitin protein ligase binding GO:0031625 9.16 TP53 RB1
4 RNA polymerase II activating transcription factor binding GO:0001102 8.96 TP53 RB1
5 disordered domain specific binding GO:0097718 8.62 TP53 RB1
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Sources for Vulvar Adenocarcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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