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MCID: VLV036
MIFTS: 32

Vulvar Disease

Categories: Reproductive diseases
Genes Tissues Related diseases Publications Symptoms & Phenotypes Drugs
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Aliases & Classifications for Vulvar Disease

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MalaCards integrated aliases for Vulvar Disease:

Name: Vulvar Disease 12 15
Vulvar Diseases 44 73
Vulvar Disorders 43

Classifications:

MalaCards categories:
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:2059
MeSH 44 D014845
NCIt 50 C27631
SNOMED-CT 68 5089007
UMLS 73 C0042994
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Summaries for Vulvar Disease

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MedlinePlus : 43 The vulva is the external part of a woman's genitals. Some problems you can have with the vulvar area include Vaginitis or vulvovaginitis, swelling or infection of the vulva and vagina Skin problems due to allergy Vulvar cancer Vulvodynia, or vulvar pain Symptoms may include redness, itching, pain, or cracks in the skin. Treatment depends on the cause.

MalaCards based summary : Vulvar Disease, also known as vulvar diseases, is related to vulvovaginitis and lichen sclerosus et atrophicus, and has symptoms including pelvic pain and pruritus vulvae. An important gene associated with Vulvar Disease is NXN (Nucleoredoxin). The drugs Acetylcholine and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include lymph node, skin and testes.

Wikipedia : 76 A vulvar disease is a particular abnormal, pathological condition that affects part or all of the vulva.... more...

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Related Diseases for Vulvar Disease

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Diseases related to Vulvar Disease via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 vulvovaginitis 9.6
2 lichen sclerosus et atrophicus 9.6
3 paine syndrome 9.6
4 cervicitis 9.6
5 breast disease 9.6
6 premenstrual tension 9.6
7 leukoplakia 9.6
8 lichen sclerosus 9.6
9 vulvar intraepithelial neoplasia 9.6
10 vulvitis 7.1 GYPC HSF4 MRAP NXN PPARGC1B

Graphical network of the top 20 diseases related to Vulvar Disease:



Diseases related to Vulvar Disease
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Symptoms & Phenotypes for Vulvar Disease

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UMLS symptoms related to Vulvar Disease:


pelvic pain, pruritus vulvae
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Drugs & Therapeutics for Vulvar Disease

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Drugs for Vulvar Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 206)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 4,Phase 3,Phase 2 51-84-3 187
2
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 22916-47-8 4189
3
Fluconazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 86386-73-4 3365
4
Clotrimazole Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 23593-75-1 2812
5
Dequalinium Approved, Investigational Phase 4 6707-58-0
6
Terconazole Approved Phase 4,Not Applicable 67915-31-5 441383
7
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 137-58-6 3676
8 abobotulinumtoxinA Phase 4,Phase 3
9 Botulinum Toxins Phase 4,Phase 3,Phase 2
10 Botulinum Toxins, Type A Phase 4,Phase 3
11 Cholinergic Agents Phase 4,Phase 3,Phase 2
12 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Not Applicable
13 onabotulinumtoxinA Phase 4,Phase 3
14 Antifungal Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
15 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
16 Cytochrome P-450 CYP2C9 Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
17 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
18 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
19 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
20 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
21 Steroid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
22 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
23 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
24 Anti-Infective Agents, Local Phase 4,Phase 3
25 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 3,Not Applicable
26 Anesthetics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
27 Anesthetics, Local Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
28 Anti-Arrhythmia Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
29 Diuretics, Potassium Sparing Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
30 Sodium Channel Blockers Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
31
Amitriptyline Approved Phase 3 50-48-6 2160
32
Perphenazine Approved Phase 3 58-39-9 4748
33
Nifedipine Approved Phase 3 21829-25-4 4485
34
Milnacipran Approved, Investigational Phase 3 92623-85-3 65833
35
Butoconazole Approved Phase 3,Not Applicable 64872-77-1, 64872-76-0 47472
36
Clindamycin Approved, Vet_approved Phase 3,Not Applicable 18323-44-9 29029
37
Amphotericin B Approved, Investigational Phase 3,Phase 2 1397-89-3 14956 5280965
38
Ketoconazole Approved, Investigational Phase 3 65277-42-1 47576 3823
39
Tetracycline Approved, Vet_approved Phase 3 60-54-8 5353990
40
Octreotide Approved, Investigational Phase 3 83150-76-9 383414 6400441
41
Capsaicin Approved Phase 2, Phase 3,Phase 1 404-86-4 1548943
42
Clobetasol Approved, Investigational Phase 3,Phase 2,Not Applicable 25122-46-7, 25122-41-2 32798 5311051
43
Cisplatin Approved Phase 3,Phase 2,Phase 1 15663-27-1 84093 441203 2767
44
Menthol Approved Phase 3,Not Applicable 2216-51-5 16666
45 Tomato Approved, Nutraceutical Phase 3
46 Adrenergic Agents Phase 3,Not Applicable
47 Amitriptyline, perphenazine drug combination Phase 3
48 Analgesics Phase 3,Phase 2,Not Applicable
49 Analgesics, Non-Narcotic Phase 3,Phase 2
50 Antidepressive Agents Phase 3,Phase 2,Not Applicable

Interventional clinical trials:

(show top 50) (show all 221)
# Name Status NCT ID Phase Drugs
1 Botox on Vulvar Vestibulitis Unknown status NCT00119886 Phase 4 Botulinum toxin
2 Epidemiological Study About the Evolution of Patients Treated for an Acute Episode of Vulvovaginal Candidiasis Completed NCT02248506 Phase 4
3 Comparative Efficacy Study of 10 mg Dequalinium Chloride (Fluomizin) in the Treatment of Vulvovaginal Candidiasis Completed NCT02242695 Phase 4 Fluomizin vaginal tablets;Canesten vaginal tablets
4 Clotrimazole Vaginal Tablet vs Fluconazole for Severe Vulvovaginal Candidiasis Completed NCT02180828 Phase 4 Clotrimazole vaginal tablet;Fluconazole
5 Terconazole Vaginal Suppository vs Fluconazole for the Treatment of Severe Vulvovaginal Candidiasis Completed NCT02180100 Phase 4 Terconazole Vaginal Suppository;Fluconazole
6 Effect of Exercise on Spread of the Miconozole Nitrate OVULE in the Vagina Completed NCT00194324 Phase 4 Miconazole nitrate
7 Study to Compare the Efficacy of Cognitive-behavioral Couple Therapy and Lidocaine for Provoked Vestibulodynia Active, not recruiting NCT01935063 Phase 4
8 Physical Therapy as Adjuvant Treatment of Vulvodynia: a Randomized Controled Trial Unknown status NCT02871661 Phase 3 Amitriptyline
9 Dysbiosis in Localized Provoked Vulvodynia (LPV) Unknown status NCT02393911 Phase 3
10 Efficacy Study of Topical Application of Nifedipine Cream to Treat Vulvar Vestibulitis Completed NCT00496184 Phase 3 Nifedipine cream topical application
11 Savella in Treatment for Provoked Vestibulodynia Completed NCT01304589 Phase 3 Milnacipran
12 Vaginal Infection Study Completed NCT00616330 Phase 3 clindamycin phosphate/butoconazole nitrate;clindamycin phosphate;butoconazole nitrate
13 Radiation Therapy or Surgery in Treating Patients With Previously Untreated Vulva Cancer With Positive Groin Lymph Nodes Completed NCT00898352 Phase 3
14 Prospective and Randomized Study to Evaluate Interest of Ultracision Use in Inguinal Lymph Nodes Curage Completed NCT00224744 Phase 3
15 Lymphatic Mapping in Treating Patients With Stage I or Stage II Cancer of the Vulva Completed NCT00003325 Phase 3
16 Therapy to Prevent Sexual Pain in Breast Cancer Survivors Completed NCT01539317 Phase 3 Topical liquid lidocaine;Topical saline
17 Study of the Efficacy and Tolerance of Intra-vaginal Treatment With a Total Freeze-dried Culture of Lcr Regenerans® in the Prevention of Relapses of Recurrent Vulvovaginal Candidiasis Completed NCT02251093 Phase 3 Lcr Regenerans;Placebo
18 The Study Of Fluconazole For Vulvovaginal Candidiasis Completed NCT01806623 Phase 3 Fluconazole
19 A Study to Compare the Efficacy and Safety of a Combination of Ketoconazole and Clindamycin Compared to Tetracycline/Amphotericin B Combination Cream for the Treatment of Bacterial Vaginosis and Vaginal Candidiasis (P08077) Completed NCT01293643 Phase 3 100 mg clindamycin /800 mg ketoconazole vaginal ovule;100 mg tetracycline hydrochloride /50 mg amphotericin B cream
20 A Study of V503, a 9-valent Human Papillomavirus (9vHPV) Vaccine in Females 12-26 Years of Age Who Have Previously Received GARDASIL™ (V503-006) Completed NCT01047345 Phase 3
21 Comparative Efficacy of Ovule vs Tablet Completed NCT00755053 Phase 3 Clotrimazole, vaginal ovule;Clotrimazole, vaginal tablet
22 Broad Spectrum HPV (Human Papillomavirus) Vaccine Study in 16-to 26-Year-Old Women (V503-001) Completed NCT00543543 Phase 3
23 Diabetes Mellitus and Vulvovaginal Candidiasis Completed NCT00353561 Phase 3 Boric;Fluconazole
24 Octreotide in Preventing Diarrhea in Patients Who Are Undergoing Radiation Therapy to the Pelvis Completed NCT00033605 Phase 3 octreotide acetate
25 Fibrin Sealant in Decreasing Lymphedema Following Surgery to Remove Lymph Nodes in Patients With Cancer of the Vulva Completed NCT00028951 Phase 3 fibrin sealant
26 A Pilot Study of the Effects of Botulinum Toxin in the Treatment of Provoked Vestibulodynia Recruiting NCT02858219 Phase 3 Botulinum Toxin Type A
27 A Study of the Effects of Topical Capsaicin in the Treatment of Provoked Vestibulodynia Recruiting NCT02854670 Phase 2, Phase 3 Capsaicin patch
28 Placebo-controlled RCT of Botulinum Toxin A as a Treatment for Provoked Vestibulodynia Recruiting NCT02773641 Phase 3 Botulinum Toxin Type A;Sterile Saline Solution
29 Clobetasol Proprionate Versus Fractionated CO2 Laser for the Treatment of Lichen Sclerosus Recruiting NCT02573883 Phase 3 Clobetasol Propionate 0.05% ointment
30 Treatment of Candidal Vulvovaginitis Using Cumin Seed Extract Vaginal Cream. Recruiting NCT03005353 Phase 2, Phase 3 Cumin seed extract;clotrimazole
31 Safety and Immunogenicity Study of V503 (GARDASIL™9, 9vHPV Vaccine) Administered to 9- to 26-Year-Old Females and Males in Vietnam Recruiting NCT03546842 Phase 3
32 ProF-001_Phase IIa Recruiting NCT03115073 Phase 2, Phase 3 Candiplus;Clotrimazole
33 Fluorescence for Sentinel Lymph Node Identification in Cancer Surgery Recruiting NCT02997553 Phase 3 Indocyanine green;Technetium99
34 Immunogenicity and Tolerability of Broad Spectrum Human Papillomavirus (HPV) Vaccine in Adult and Young Adult Women (V503-004) Active, not recruiting NCT03158220 Phase 3
35 A Study of V503 (A Multivalent Human Papillomavirus [HPV] L1 Virus-Like Particle [VLP] Vaccine) in Preadolescents and Adolescents (V503-002) Active, not recruiting NCT00943722 Phase 3
36 A Study of Oral VT-1161 for the Treatment of Patients With Recurrent Vaginal Candidiasis (Yeast Infection) Not yet recruiting NCT03562156 Phase 3 VT-1161;Placebo
37 A Study of Oral VT-1161 for the Treatment of Patients With Recurrent Vaginal Candidiasis (Yeast Infection) Not yet recruiting NCT03561701 Phase 3 VT-1161;Placebo
38 Ketoconazole Gel Versus Terconazole Cream for Vaginal Candidiasis Not yet recruiting NCT03473418 Phase 3 Ketoconazole;Terconazole
39 Efficacy, Safety LactiSal 1% Gel, LactSal 50 mg, Clotrimazole 100 mg Tablet in Treatment Vulvovaginal Candidiasis Not yet recruiting NCT02907307 Phase 3 Clotrimazole vaginal tablet 100mg
40 Radiation Therapy With or Without Cisplatin in Treating Patients With Stage I, Stage II, or Stage III Cancer of the Vulva Terminated NCT00006096 Phase 3 cisplatin
41 Flexitouch® Home Maintenance Therapy or Standard Home Maintenance Therapy in Treating Patients With Lower-Extremity Lymphedema Caused by Treatment for Cervical Cancer, Vulvar Cancer, or Endometrial Cancer Terminated NCT00577317 Phase 3
42 Nutritional Supplements in Improving Quality of Life During First-Line Chemotherapy in Patients With Metastatic Gynecological Cancer Unknown status NCT00905658 Phase 2
43 Phase I/II Randomized, Placebo-Controlled Study of Capsaicin for Interstitial Cystitis and Vulvar Vestibulitis Completed NCT00004316 Phase 1, Phase 2 capsaicin
44 Infiltration of the Vestibulum Vaginae With Botulin Toxin in Patients With Localized Provoked Vulvodynia Completed NCT01747161 Phase 2 Botulin toxin;physiological water
45 Enoxaparin as Treatment for Vulvodynia Completed NCT00874484 Phase 2 Clexane (enoxaparin)
46 CC-10004 For The Treatment Of Vulvodynia Completed NCT00814632 Phase 2 CC-10004
47 Safety and Efficacy of Two Vaginal Products Versus Placebo in Patients With Vaginal Discomfort Completed NCT00590590 Phase 2 Lidocaine/Diphenhydramine;lidocaine;placebo
48 Safety and Efficacy of Oral Encochleated Amphotericin B (CAMB/MAT2203) in the Treatment of Vulvovaginal Candidiasis (VVC) Completed NCT02971007 Phase 2 Oral Encochleated Amphotericin B (CAMB);Fluconazole
49 RADIANT: CD101 vs Standard of Care in Subjects With Acute Vaginal Yeast Infections Completed NCT02733432 Phase 2 CD101 Vaginal Gel (3%);CD101 External gel (1%);CD101 Vaginal Ointment (6%);CD101 External ointment (1%);Fluconazole
50 Tacrolimus Versus Clobetasol Propionate in the Treatment of Vulvar Lichen Sclerosus Completed NCT00757874 Phase 2 Tacrolimus cream;Clobetasol cream

Search NIH Clinical Center for Vulvar Disease

Cochrane evidence based reviews: vulvar diseases

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Genetic Tests for Vulvar Disease

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Anatomical Context for Vulvar Disease

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MalaCards organs/tissues related to Vulvar Disease:

41
Lymph Node, Skin, Testes, Cervix, T Cells, Prostate, Brain
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Publications for Vulvar Disease

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Articles related to Vulvar Disease:

(show top 50) (show all 54)
# Title Authors Year
1
"The Future of Vulvar Disease: New and Ongoing Challenges": Presidential Lecture - XXIV World Congress 2017, Mendoza, Argentina. ( 29474239 )
2018
2
Lichenoid vulvar disease: A review. ( 28492056 )
2017
3
Evaluation and Management of Vulvar Disease. ( 28778648 )
2017
4
Primary extramammary invasive Paget's vulvar disease: what is the standard, what are the challenges and what is the future for radiotherapy? ( 27473174 )
2016
5
Sexual well-being in patients with vulvar disease: results from a preliminary prospective matched case-control study. ( 26342683 )
2015
6
Psychosexual Aspects of Vulvar Disease. ( 26125964 )
2015
7
Paediatric vulvar disease. ( 25134451 )
2014
8
Effect of the human papillomavirus (HPV) quadrivalent vaccine in a subgroup of women with cervical and vulvar disease: retrospective pooled analysis of trial data. ( 22454089 )
2012
9
Considerations for disease impact and outcome measures in vulvar disease. ( 22659774 )
2012
10
Human papillomavirus infections and vulvar disease development. ( 19505910 )
2009
11
Bladder and bowel symptoms among women with vulvar disease: are they universal? ( 18210896 )
2007
12
Vulvar disease pearls. ( 16677963 )
2006
13
Vulvar disease update. ( 17249297 )
2006
14
Vulvar disease: a pelvic floor pain disorder? ( 15970821 )
2005
15
Vulvar disease. ( 12100817 )
2002
16
The serious clinical problem of chronic vulvar disease. ( 12230080 )
2002
17
Adverse behavioral and sexual factors in chronic vulvar disease. ( 10920305 )
2000
18
Vulvar disease in children: a clinical audit of 130 cases. ( 10720979 )
2000
19
Dyspareunia and vulvar disease. ( 9839263 )
1998
20
The commonest causes of symptomatic vulvar disease: a dermatologist's perspective. ( 8936065 )
1996
21
Treatment of human papillomavirus-associated vulvar disease with the CO2-laser. Physical and histological aspects with use of a new scanning device, the SwiftLase. ( 8933926 )
1996
22
Clinicopathologic analysis of 370 cases of vulvar intraepithelial neoplasia. Italian Study Group on Vulvar Disease. ( 8887191 )
1996
23
Vulvar disease in the pediatric population. ( 8723821 )
1996
24
Office gynecology for the primary care physician, part II: pelvic pain, vulvar disease, disorders of menstruation, premenstrual syndrome, and breast disease. ( 8614176 )
1996
25
Proceedings of the 11th International Congress of the International Society for the Study of Vulvar Disease. Oxford, England, September 1991. ( 8095071 )
1993
26
International Society for the Study of Vulvar Disease. ( 8441124 )
1993
27
Advances in vulvar disease: lichen sclerosus et atrophicus et al. ( 1739579 )
1992
28
Ultrasonic surgical aspiration in the treatment of vulvar disease. ( 2002980 )
1991
29
Ultrasonic surgical aspiration in the treatment of vulvar disease. ( 1876389 )
1991
30
New nomenclature for vulvar disease. Report of the Committee on Terminology of the International Society for the Study of Vulvar Disease. ( 2352242 )
1990
31
Proceedings of the 10th International Congress of the International Society for the Study of Vulvar Disease, Washington, D.C., October 1989. ( 1980515 )
1990
32
Proceedings of the Tenth World Congress of the International Society for the Study of Vulvar Disease, Washington, D.C., October 22-26, 1989. ( 1980928 )
1990
33
Superficial laser vulvectomy. IV. Extended laser vaporization and adjunctive 5-fluorouracil therapy of human papillomavirus-associated vulvar disease. ( 2166264 )
1990
34
Surgical-procedure terminology for the vulva and vagina. Report of an International Society for the Study of Vulvar Disease Task Force. ( 2277365 )
1990
35
The 1989 presidential address. International Society for the Study of Vulvar Disease. ( 2277371 )
1990
36
New nomenclature for vulvar disease: International Society for the Study of Vulvar Disease. ( 2707802 )
1989
37
Proceedings of the ninth world congress of the International Society for the Study of Vulvar Disease. Queensland, Australia, September 1987. ( 3172073 )
1988
38
International Society for the Study of Vulvar Disease--progress report. ( 3395571 )
1988
39
Proceedings of the Eighth World Congress of the International Society for the Study of Vulvar Disease. Mariehamn, Finland, September 9-15, 1985. ( 3772896 )
1986
40
Selected ISSVD (International Society for the Study of Vulvar Disease) abstracts. ( 3783540 )
1986
41
The carbon dioxide laser in the treatment of vulvar disease. ( 3921303 )
1985
42
Vulvar disease. ( 3987125 )
1985
43
Vulvar disease. A spectrum of clinical pictures. ( 6296804 )
1983
44
Hormone receptors in dystrophic and neoplastic vulvar disease. Preliminary considerations. ( 6313258 )
1983
45
Further observations on the effect of topical progesterone on vulvar disease. ( 453296 )
1979
46
New nomenclature for vulvar disease. ( 174037 )
1976
47
Vulvar disease. ( 180357 )
1976
48
New nomenclature for vulvar disease. ( 1002872 )
1976
49
New nomenclature for vulvar disease. ( 174431 )
1976
50
The International Society for the Study of Vulvar Disease. A brief history. ( 20365 )
1976
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Variations for Vulvar Disease

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Expression for Vulvar Disease

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Search GEO for disease gene expression data for Vulvar Disease.
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Pathways for Vulvar Disease

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GO Terms for Vulvar Disease

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Sources for Vulvar Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
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58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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