Vulvar Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: VLV036 MIFTS: 40	Vulvar Disease Categories: Reproductive diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Vulvar Disease

MalaCards integrated aliases for Vulvar Disease:

Name: Vulvar Disease ¹² ¹⁵

Vulvar Diseases ⁴⁴ ⁷³

Vulvar Disorders ⁴³

Classifications:

MalaCards categories:
Anatomical: Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:2059

MeSH ⁴⁴ D014845

NCIt ⁵⁰ C27631

SNOMED-CT ⁶⁸ 5089007

UMLS ⁷³ C0042994

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Summaries for Vulvar Disease

MedlinePlus : ⁴³ The vulva is the external part of a woman's genitals. Some problems you can have with the vulvar area include Vaginitis or vulvovaginitis, swelling or infection of the vulva and vagina Skin problems due to allergy Vulvar cancer Vulvodynia, or vulvar pain Symptoms may include redness, itching, pain, or cracks in the skin. Treatment depends on the cause.

MalaCards based summary : Vulvar Disease, also known as vulvar diseases, is related to vulvar dystrophy and vulvitis, and has symptoms including pelvic pain and pruritus vulvae. An important gene associated with Vulvar Disease is CDKN2A (Cyclin Dependent Kinase Inhibitor 2A), and among its related pathways/superpathways are Oncogene Induced Senescence and Bladder cancer. The drugs Acetylcholine and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and kidney.

Disease Ontology : ¹² A female reproductive system diseaes that is located in the vulva.

Wikipedia : ⁷⁶ A vulvar disease is a particular abnormal, pathological condition that affects part or all of the vulva.... more...

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Related Diseases for Vulvar Disease

Diseases related to Vulvar Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 133)

#	Related Disease	Score	Top Affiliating Genes
1	vulvar dystrophy	31.7	CDKN2A LINC01191
2	vulvitis	31.6	KRT7 LINC01191
3	vulvar intraepithelial neoplasia	29.9	KRT7 TP53
4	in situ carcinoma	29.7	CDKN2A TP53
5	ulceration of vulva	11.0
6	atrophic vulva	11.0
7	bladder squamous cell carcinoma	10.3	CDKN2A TP53
8	keratinizing squamous cell carcinoma	10.3	CDKN2A TP53
9	spitz nevus	10.3	CDKN2A TP53
10	scrotal carcinoma	10.3	CDKN2A TP53
11	bartholin's gland disease	10.3	CDKN2A TP53
12	anal squamous cell carcinoma	10.3	CDKN2A TP53
13	megaesophagus	10.2	CDKN2A TP53
14	gastric adenosquamous carcinoma	10.2	CDKN2A TP53
15	anogenital venereal wart	10.2	CDKN2A TP53
16	inverted transitional papilloma	10.2	CDKN2A KRT7
17	oral leukoplakia	10.2	CDKN2A TP53
18	meningeal melanomatosis	10.2	CDKN2A TP53
19	adenoid basal cell carcinoma	10.2	CDKN2A KRT7
20	malignant spiradenoma	10.2	KRT7 TP53
21	bile duct adenoma	10.2	CDKN2A KRT7
22	suppressor of tumorigenicity 3	10.2	CDKN2A TP53
23	spiradenoma	10.2	KRT7 TP53
24	endocervical carcinoma	10.2	CDKN2A KRT7
25	nasal cavity cancer	10.2	CDKN2A KRT7
26	dedifferentiated liposarcoma	10.2	CDKN2A TP53
27	anal canal carcinoma	10.2	CDKN2A KRT7
28	papillary serous adenocarcinoma	10.2	KRT7 TP53
29	female reproductive endometrioid cancer	10.2	KRT7 TP53
30	cervix small cell carcinoma	10.2	CDKN2A TP53
31	mucinous bronchioloalveolar adenocarcinoma	10.2	CDKN2A KRT7
32	verrucous carcinoma	10.2	CDKN2A TP53
33	well-differentiated liposarcoma	10.2	CDKN2A KRT7
34	prostate squamous cell carcinoma	10.2	KRT7 TP53
35	optic nerve neoplasm	10.2	CDKN2A TP53
36	pleomorphic carcinoma	10.2	KRT7 TP53
37	nasal cavity squamous cell carcinoma	10.2	CDKN2A KRT7
38	biliary papillomatosis	10.2	KRT7 TP53
39	eccrine sweat gland neoplasm	10.2	KRT7 TP53
40	juvenile pilocytic astrocytoma	10.2	CDKN2A TP53
41	appendix cancer	10.2	KRT7 TP53
42	cervical adenosquamous carcinoma	10.2	CDKN2A KRT7
43	epithelial-myoepithelial carcinoma	10.2	KRT7 TP53
44	pre-malignant neoplasm	10.2	CDKN2A TP53
45	cystic teratoma	10.2	KRT7 TP53
46	recessive dystrophic epidermolysis bullosa	10.2	CDKN2A TP53
47	adenocarcinoma in situ	10.2	CDKN2A KRT7
48	mixed cell type cancer	10.2	KRT7 TP53
49	squamous cell papilloma	10.2	CDKN2A TP53
50	non-invasive bladder papillary urothelial neoplasm	10.2	TP53 UPK3A

Graphical network of the top 20 diseases related to Vulvar Disease:

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Symptoms & Phenotypes for Vulvar Disease

UMLS symptoms related to Vulvar Disease:

pelvic pain, pruritus vulvae

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Drugs & Therapeutics for Vulvar Disease

Drugs for Vulvar Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 210)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Acetylcholine

Approved

Phase 4,Phase 3,Phase 2

51-84-3

187

Miconazole

Approved, Investigational, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

22916-47-8

4189

Fluconazole

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1

86386-73-4

3365

Clotrimazole

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1

23593-75-1

2812

Dequalinium

Approved, Investigational

Phase 4

6707-58-0

Terconazole

Approved

Phase 4,Phase 3,Not Applicable

67915-31-5

441383

Petrolatum

Approved, Investigational

Phase 4,Phase 2,Not Applicable

8009-03-8

Acetylcholine Release Inhibitors

Phase 4,Phase 3,Phase 2

Botulinum Toxins

Phase 4,Phase 3,Phase 2

onabotulinumtoxinA

Phase 4,Phase 3,Phase 2

Cholinergic Agents

Phase 4,Phase 3,Phase 2

abobotulinumtoxinA

Phase 4,Phase 3,Phase 2

Neurotransmitter Agents

Phase 4,Phase 3,Phase 2,Not Applicable

Botulinum Toxins, Type A

Phase 4,Phase 3,Phase 2

Antifungal Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Anti-Infective Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Cytochrome P-450 Enzyme Inhibitors

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Steroid Synthesis Inhibitors

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Cytochrome P-450 CYP2C9 Inhibitors

Phase 4,Phase 3,Phase 2,Phase 1

Hormone Antagonists

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Hormones

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Cytochrome P-450 CYP2C19 Inhibitors

Phase 4,Phase 3,Phase 2,Phase 1

Estrogens

Phase 4,Not Applicable

Cytochrome P-450 CYP3A Inhibitors

Phase 4,Phase 3,Not Applicable

Anti-Infective Agents, Local

Phase 4,Phase 3

Tea

Phase 4

Amitriptyline

Approved

Phase 3

50-48-6

2160

Perphenazine

Approved

Phase 3

58-39-9

4748

Tomato

Approved

Phase 3

Nifedipine

Approved

Phase 3

21829-25-4

4485

Milnacipran

Approved, Investigational

Phase 3

92623-85-3

65833

Butoconazole

Approved

Phase 3,Not Applicable

64872-77-1, 64872-76-0

47472

Clindamycin

Approved, Vet_approved

Phase 3,Not Applicable

18323-44-9

29029

Lidocaine

Approved, Vet_approved

Phase 3,Phase 2,Phase 1,Not Applicable

137-58-6

3676

Amphotericin B

Approved, Investigational

Phase 3,Phase 2

1397-89-3

5280965 14956

Tetracycline

Approved, Vet_approved

Phase 3

60-54-8

5353990

Ketoconazole

Approved, Investigational

Phase 3

65277-42-1

3823 47576

Octreotide

Approved, Investigational

Phase 3

83150-76-9

383414 6400441

Capsaicin

Approved

Phase 2, Phase 3,Phase 1

404-86-4

1548943

Clobetasol

Approved, Experimental, Investigational

Phase 3,Phase 2,Not Applicable

25122-46-7, 25122-41-2

5311051 32798

Cisplatin

Approved

Phase 3,Phase 2,Phase 1

15663-27-1

2767 441203 84093

Antidepressive Agents, Tricyclic

Phase 3,Not Applicable

Central Nervous System Depressants

Phase 3,Phase 2,Phase 1,Not Applicable

Analgesics, Non-Narcotic

Phase 3,Phase 2,Phase 1

Amitriptyline, perphenazine drug combination

Phase 3

Antidepressive Agents

Phase 3,Phase 2,Not Applicable

Analgesics

Phase 3,Phase 2,Phase 1,Not Applicable

Psychotropic Drugs

Phase 3,Phase 2,Not Applicable

Antipsychotic Agents

Phase 3

Interventional clinical trials:

(show top 50) (show all 234)

#	Name	Status	NCT ID	Phase	Drugs
1	Botox on Vulvar Vestibulitis	Unknown status	NCT00119886	Phase 4	Botulinum toxin
2	Epidemiological Study About the Evolution of Patients Treated for an Acute Episode of Vulvovaginal Candidiasis	Completed	NCT02248506	Phase 4
3	Comparative Efficacy Study of 10 mg Dequalinium Chloride (Fluomizin) in the Treatment of Vulvovaginal Candidiasis	Completed	NCT02242695	Phase 4	Fluomizin vaginal tablets;Canesten vaginal tablets
4	Clotrimazole Vaginal Tablet vs Fluconazole for Severe Vulvovaginal Candidiasis	Completed	NCT02180828	Phase 4	Clotrimazole vaginal tablet;Fluconazole
5	Terconazole Vaginal Suppository vs Fluconazole for the Treatment of Severe Vulvovaginal Candidiasis	Completed	NCT02180100	Phase 4	Terconazole Vaginal Suppository;Fluconazole
6	Effect of Exercise on Spread of the Miconozole Nitrate OVULE in the Vagina	Completed	NCT00194324	Phase 4	Miconazole nitrate
7	Topical Treatment for Sexual Pain, Vulvar Pain, in Postmenopausal Women Not Taking Estrogens or Similiar Hormones	Recruiting	NCT03682601	Phase 4	Sinecatechins Topical
8	Physical Therapy as Adjuvant Treatment of Vulvodynia: a Randomized Controled Trial	Unknown status	NCT02871661	Phase 3	Amitriptyline
9	Dysbiosis in Localized Provoked Vulvodynia (LPV)	Unknown status	NCT02393911	Phase 3
10	Efficacy Study of Topical Application of Nifedipine Cream to Treat Vulvar Vestibulitis	Completed	NCT00496184	Phase 3	Nifedipine cream topical application
11	Savella in Treatment for Provoked Vestibulodynia	Completed	NCT01304589	Phase 3	Milnacipran
12	Vaginal Infection Study	Completed	NCT00616330	Phase 3	clindamycin phosphate/butoconazole nitrate;clindamycin phosphate;butoconazole nitrate
13	Radiation Therapy or Surgery in Treating Patients With Previously Untreated Vulva Cancer With Positive Groin Lymph Nodes	Completed	NCT00898352	Phase 3
14	Prospective and Randomized Study to Evaluate Interest of Ultracision Use in Inguinal Lymph Nodes Curage	Completed	NCT00224744	Phase 3
15	Lymphatic Mapping in Treating Patients With Stage I or Stage II Cancer of the Vulva	Completed	NCT00003325	Phase 3
16	Immunogenicity and Tolerability of Broad Spectrum Human Papillomavirus (HPV) Vaccine in Adult and Young Adult Women (V503-004)	Completed	NCT03158220	Phase 3
17	Therapy to Prevent Sexual Pain in Breast Cancer Survivors	Completed	NCT01539317	Phase 3	Topical liquid lidocaine;Topical saline
18	Study of the Efficacy and Tolerance of Intra-vaginal Treatment With a Total Freeze-dried Culture of Lcr Regenerans® in the Prevention of Relapses of Recurrent Vulvovaginal Candidiasis	Completed	NCT02251093	Phase 3	Lcr Regenerans;Placebo
19	The Study Of Fluconazole For Vulvovaginal Candidiasis	Completed	NCT01806623	Phase 3	Fluconazole
20	A Study to Compare the Efficacy and Safety of a Combination of Ketoconazole and Clindamycin Compared to Tetracycline/Amphotericin B Combination Cream for the Treatment of Bacterial Vaginosis and Vaginal Candidiasis (P08077)	Completed	NCT01293643	Phase 3	100 mg clindamycin /800 mg ketoconazole vaginal ovule;100 mg tetracycline hydrochloride /50 mg amphotericin B cream
21	A Study of V503, a 9-valent Human Papillomavirus (9vHPV) Vaccine in Females 12-26 Years of Age Who Have Previously Received GARDASIL™ (V503-006)	Completed	NCT01047345	Phase 3
22	Comparative Efficacy of Ovule vs Tablet	Completed	NCT00755053	Phase 3	Clotrimazole, vaginal ovule;Clotrimazole, vaginal tablet
23	Broad Spectrum HPV (Human Papillomavirus) Vaccine Study in 16-to 26-Year-Old Women (V503-001)	Completed	NCT00543543	Phase 3
24	Diabetes Mellitus and Vulvovaginal Candidiasis	Completed	NCT00353561	Phase 3	Boric;Fluconazole
25	Octreotide in Preventing Diarrhea in Patients Who Are Undergoing Radiation Therapy to the Pelvis	Completed	NCT00033605	Phase 3	octreotide acetate
26	Fibrin Sealant in Decreasing Lymphedema Following Surgery to Remove Lymph Nodes in Patients With Cancer of the Vulva	Completed	NCT00028951	Phase 3	fibrin sealant
27	A Pilot Study of the Effects of Botulinum Toxin in the Treatment of Provoked Vestibulodynia	Recruiting	NCT02858219	Phase 3	Botulinum Toxin Type A
28	A Study of the Effects of Topical Capsaicin in the Treatment of Provoked Vestibulodynia	Recruiting	NCT02854670	Phase 2, Phase 3	Capsaicin patch
29	Placebo-controlled RCT of Botulinum Toxin A as a Treatment for Provoked Vestibulodynia	Recruiting	NCT02773641	Phase 3	Botulinum Toxin Type A;Sterile Saline Solution
30	Clobetasol Proprionate Versus Fractionated CO2 Laser for the Treatment of Lichen Sclerosus	Recruiting	NCT02573883	Phase 3	Clobetasol Propionate 0.05% ointment
31	Treatment of Candidal Vulvovaginitis Using Cumin Seed Extract Vaginal Cream.	Recruiting	NCT03005353	Phase 2, Phase 3	Cumin seed extract;clotrimazole
32	Efficacy and Safety of Oral Ibrexafungerp (SCY-078) vs. Placebo in Subjects With Acute Vulvovaginal Candidiasis	Recruiting	NCT03734991	Phase 3	Ibrexafungerp;Placebo
33	A Study of Oral VT-1161 for the Treatment of Patients With Recurrent Vaginal Candidiasis (Yeast Infection)	Recruiting	NCT03562156	Phase 3	VT-1161;Placebo
34	A Study of Oral VT-1161 for the Treatment of Patients With Recurrent Vaginal Candidiasis (Yeast Infection)	Recruiting	NCT03561701	Phase 3	VT-1161;Placebo
35	ProF-001_Phase IIa	Recruiting	NCT03115073	Phase 2, Phase 3	Candiplus;Clotrimazole
36	Fluorescence for Sentinel Lymph Node Identification in Cancer Surgery	Recruiting	NCT02997553	Phase 3	Indocyanine green;Technetium99
37	Safety and Immunogenicity Study of V503 (GARDASIL™9, 9vHPV Vaccine) Administered to 9- to 26-Year-Old Females and Males in Vietnam	Active, not recruiting	NCT03546842	Phase 3
38	A Study of V503 (A Multivalent Human Papillomavirus [HPV] L1 Virus-Like Particle [VLP] Vaccine) in Preadolescents and Adolescents (V503-002)	Active, not recruiting	NCT00943722	Phase 3
39	Ketoconazole Gel Versus Terconazole Cream for Vaginal Candidiasis	Not yet recruiting	NCT03473418	Phase 3	Ketoconazole;Terconazole
40	Efficacy, Safety LactiSal 1% Gel, LactSal 50 mg, Clotrimazole 100 mg Tablet in Treatment Vulvovaginal Candidiasis	Not yet recruiting	NCT02907307	Phase 3	Clotrimazole vaginal tablet 100mg
41	Radiation Therapy With or Without Cisplatin in Treating Patients With Stage I, Stage II, or Stage III Cancer of the Vulva	Terminated	NCT00006096	Phase 3	cisplatin
42	Flexitouch® Home Maintenance Therapy or Standard Home Maintenance Therapy in Treating Patients With Lower-Extremity Lymphedema Caused by Treatment for Cervical Cancer, Vulvar Cancer, or Endometrial Cancer	Terminated	NCT00577317	Phase 3
43	Nutritional Supplements in Improving Quality of Life During First-Line Chemotherapy in Patients With Metastatic Gynecological Cancer	Unknown status	NCT00905658	Phase 2
44	Phase I/II Randomized, Placebo-Controlled Study of Capsaicin for Interstitial Cystitis and Vulvar Vestibulitis	Completed	NCT00004316	Phase 1, Phase 2	capsaicin
45	Infiltration of the Vestibulum Vaginae With Botulin Toxin in Patients With Localized Provoked Vulvodynia	Completed	NCT01747161	Phase 2	Botulin toxin;physiological water
46	Enoxaparin as Treatment for Vulvodynia	Completed	NCT00874484	Phase 2	Clexane (enoxaparin)
47	CC-10004 For The Treatment Of Vulvodynia	Completed	NCT00814632	Phase 2	CC-10004
48	Safety and Efficacy of Two Vaginal Products Versus Placebo in Patients With Vaginal Discomfort	Completed	NCT00590590	Phase 2	Lidocaine/Diphenhydramine;lidocaine;placebo
49	Safety and Efficacy of Oral Encochleated Amphotericin B (CAMB/MAT2203) in the Treatment of Vulvovaginal Candidiasis (VVC)	Completed	NCT02971007	Phase 2	Oral Encochleated Amphotericin B (CAMB);Fluconazole
50	RADIANT: CD101 vs Standard of Care in Subjects With Acute Vaginal Yeast Infections	Completed	NCT02733432	Phase 2	CD101 Vaginal Gel (3%);CD101 External gel (1%);CD101 Vaginal Ointment (6%);CD101 External ointment (1%);Fluconazole

Search NIH Clinical Center for Vulvar Disease

Cochrane evidence based reviews: vulvar diseases

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Genetic Tests for Vulvar Disease

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Anatomical Context for Vulvar Disease

MalaCards organs/tissues related to Vulvar Disease:

⁴¹

Skin, Lung, Kidney, Liver, Tongue, Ovary, Cervix

The Foundational Model of Anatomy Ontology organs/tissues related to Vulvar Disease:

¹⁹

The Vulva

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Publications for Vulvar Disease

Articles related to Vulvar Disease:

(show top 50) (show all 67)

#	Title	Authors	Year
1	&quot;The Future of Vulvar Disease: New and Ongoing Challenges&quot;: Presidential Lecture - XXIV World Congress 2017, Mendoza, Argentina. ( 29474239 )		2018
2	Lichenoid vulvar disease: A review. ( 28492056 )	Fruchter R....Pomeranz M.K.	2017
3	Evaluation and Management of Vulvar Disease. ( 28778648 )	Venkatesan A.	2017
4	HPV-related vulvar diseases and perspectives of p16INK4a immunochemistry: a review of the literature. ( 28574130 )	Carrone A...Benedetti Panici P	2017
5	Primary extramammary invasive Paget's vulvar disease: what is the standard, what are the challenges and what is the future for radiotherapy? ( 27473174 )	Tolia M...Kyrgias G	2016
6	What Do Patients Want? A Needs Assessment of Vulvodynia Patients Attending a Vulvar Diseases Clinic. ( 27484917 )	LePage K...Selk A	2016
7	Sexual well-being in patients with vulvar disease: results from a preliminary prospective matched case-control study. ( 26342683 )	Wylomanski S....QuAcreux G.	2015
8	Psychosexual Aspects of Vulvar Disease. ( 26125964 )	Rosenbaum T.Y....Wilhite M.	2015
9	Lower Urinary Tract and Functional Bowel Symptoms in Women With Vulvar Diseases and Controls. ( 26052645 )	Swenson CW...Berger MB	2015
10	Paediatric vulvar disease. ( 25134451 )	Simpson R.C....Murphy R.	2014
11	Effect of the human papillomavirus (HPV) quadrivalent vaccine in a subgroup of women with cervical and vulvar disease: retrospective pooled analysis of trial data. ( 22454089 )	Joura E.A....Haupt R.M.	2012
12	Considerations for disease impact and outcome measures in vulvar disease. ( 22659774 )	Simpson R.C....Murphy R.	2012
13	Prevalences of and risk factors for vulvar diseases in Nepal: a hospital-based study. ( 21244379 )	Pathak D...Dhali TK	2011
14	The impact of the latest classification system of benign vulvar diseases on the management of women with chronic vulvar pruritus. ( 21508567 )	Kelekci KH...Kelekci S	2011
15	Human papillomavirus infections and vulvar disease development. ( 19505910 )		2009
16	Vulvar diseases of the tropics: a review. ( 19301568 )	Okoduwa C...Heller DS	2009
17	Bladder and bowel symptoms among women with vulvar disease: are they universal? ( 18210896 )		2007
18	Vulvar disease pearls. ( 16677963 )		2006
19	Vulvar disease update. ( 17249297 )		2006
20	Vulvar disease: a pelvic floor pain disorder? ( 15970821 )	Kennedy C.M....Galask R.P.	2005
21	Vulvar disease. ( 12100817 )	Foster D.C.	2002
22	The serious clinical problem of chronic vulvar disease. ( 12230080 )		2002
23	Adverse behavioral and sexual factors in chronic vulvar disease. ( 10920305 )	Marin M.G....Dennerstein G.J.	2000
24	Vulvar disease in children: a clinical audit of 130 cases. ( 10720979 )		2000
25	Dyspareunia and vulvar disease. ( 9839263 )	Marin M.G....Sfameni S.	1998
26	The commonest causes of symptomatic vulvar disease: a dermatologist's perspective. ( 8936065 )	Fischer G.O.	1996
27	Treatment of human papillomavirus-associated vulvar disease with the CO2-laser. Physical and histological aspects with use of a new scanning device, the SwiftLase. ( 8933926 )	SpAPrri S....Dreher E.	1996
28	Clinicopathologic analysis of 370 cases of vulvar intraepithelial neoplasia. Italian Study Group on Vulvar Disease. ( 8887191 )		1996
29	Vulvar disease in the pediatric population. ( 8723821 )	Ridley C.M.	1996
30	Office gynecology for the primary care physician, part II: pelvic pain, vulvar disease, disorders of menstruation, premenstrual syndrome, and breast disease. ( 8614176 )	Klein T.A.	1996
31	Proceedings of the 11th International Congress of the International Society for the Study of Vulvar Disease. Oxford, England, September 1991. ( 8095071 )		1993
32	International Society for the Study of Vulvar Disease. ( 8441124 )		1993
33	Advances in vulvar disease: lichen sclerosus et atrophicus et al. ( 1739579 )		1992
34	Vulvar diseases. ( 1606758 )		1992
35	General principles in the diagnosis and treatment of vulvar diseases. ( 1606759 )	Turner ML...Marinoff SC	1992
36	Ultrasonic surgical aspiration in the treatment of vulvar disease. ( 2002980 )	Rader J.S....Rosenshein N.B.	1991
37	Ultrasonic surgical aspiration in the treatment of vulvar disease. ( 1876389 )		1991
38	New nomenclature for vulvar disease. Report of the Committee on Terminology of the International Society for the Study of Vulvar Disease. ( 2352242 )		1990
39	Proceedings of the 10th International Congress of the International Society for the Study of Vulvar Disease, Washington, D.C., October 1989. ( 1980515 )		1990
40	Proceedings of the Tenth World Congress of the International Society for the Study of Vulvar Disease, Washington, D.C., October 22-26, 1989. ( 1980928 )		1990
41	Superficial laser vulvectomy. IV. Extended laser vaporization and adjunctive 5-fluorouracil therapy of human papillomavirus-associated vulvar disease. ( 2166264 )	Reid R....Stoler M.	1990
42	Surgical-procedure terminology for the vulva and vagina. Report of an International Society for the Study of Vulvar Disease Task Force. ( 2277365 )		1990
43	The 1989 presidential address. International Society for the Study of Vulvar Disease. ( 2277371 )		1990
44	A critique of current classifications of vulvar diseases. ( 2203271 )	Kiryu H...Ackerman AB	1990
45	New nomenclature for vulvar disease: International Society for the Study of Vulvar Disease. ( 2707802 )	Ridley C.M....Lynch P.J.	1989
46	Proceedings of the ninth world congress of the International Society for the Study of Vulvar Disease. Queensland, Australia, September 1987. ( 3172073 )		1988
47	International Society for the Study of Vulvar Disease--progress report. ( 3395571 )	Ridley CM	1988
48	Proceedings of the Eighth World Congress of the International Society for the Study of Vulvar Disease. Mariehamn, Finland, September 9-15, 1985. ( 3772896 )		1986
49	Selected ISSVD (International Society for the Study of Vulvar Disease) abstracts. ( 3783540 )		1986
50	The carbon dioxide laser in the treatment of vulvar disease. ( 3921303 )	Kaufman R.H....Friedrich E.G.	1985

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Genes for Vulvar Disease

Genes related to Vulvar Disease (0 elite genes):

(show all 11)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	16.36	DISEASES inferred ¹⁵
2	TP53	Tumor Protein P53	Protein Coding	15.9	DISEASES inferred ¹⁵
3	KRT13	Keratin 13	Protein Coding	15.09	DISEASES inferred ¹⁵
4	KRT7	Keratin 7	Protein Coding	15.03	DISEASES inferred ¹⁵
5	PLXDC2	Plexin Domain Containing 2	Protein Coding	14.62	DISEASES inferred ¹⁵
6	SCN10A	Sodium Voltage-Gated Channel Alpha Subunit 10	Protein Coding	14.5	DISEASES inferred ¹⁵
7	UPK3A	Uroplakin 3A	Protein Coding	14.28	DISEASES inferred ¹⁵
8	SERPINB3	Serpin Family B Member 3	Protein Coding	14.17	DISEASES inferred ¹⁵
9	LINC01191	Long Intergenic Non-Protein Coding RNA 1191	RNA Gene	8.72	DISEASES inferred ¹⁵
10	MIR3147	MicroRNA 3147	RNA Gene	5.64	DISEASES inferred ¹⁵
11	GP5	Glycoprotein V Platelet	Protein Coding	4.98	DISEASES inferred ¹⁵

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Variations for Vulvar Disease

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Expression for Vulvar Disease

Search GEO for disease gene expression data for Vulvar Disease.

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Pathways for Vulvar Disease

Pathways related to Vulvar Disease according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Oncogene Induced Senescence ⁶⁶	10.76	CDKN2A TP53
2	Bladder cancer ³⁷ ¹	10.66	CDKN2A TP53 UPK3A
3	Inhibition of Ribosome Biogenesis by p14(ARF) ⁶⁴	10.5	CDKN2A TP53
4	TP53 Network ¹ Show member pathways Activation, translocation and oligomerization of BAX ⁶⁶	10.3	CDKN2A TP53

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GO Terms for Vulvar Disease

Cellular components related to Vulvar Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular exosome	GO:0070062	9.1	GP5 KRT13 KRT7 SCN10A SERPINB3 UPK3A

Biological processes related to Vulvar Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	replicative senescence	GO:0090399	8.62	CDKN2A TP53

Molecular functions related to Vulvar Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	disordered domain specific binding	GO:0097718	8.62	CDKN2A TP53

Sources

Sources for Vulvar Disease

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia