Vulvar Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: VLV036 MIFTS: 46	Vulvar Disease Categories: Reproductive diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Vulvar Disease

MalaCards integrated aliases for Vulvar Disease:

Name: Vulvar Disease ¹² ¹⁵

Vulvar Diseases ⁴⁵ ⁷⁴

Vulvar Disorders ⁴⁴

Classifications:

MalaCards categories:
Anatomical: Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:2059

MeSH ⁴⁵ D014845

NCIt ⁵¹ C27631

SNOMED-CT ⁶⁹ 5089007

UMLS ⁷⁴ C0042994

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Summaries for Vulvar Disease

MedlinePlus : ⁴⁴ The vulva is the external part of a woman's genitals. Some problems you can have with the vulvar area include Vaginitis or vulvovaginitis, swelling or infection of the vulva and vagina Skin problems due to allergy Vulvar cancer Vulvodynia, or vulvar pain Symptoms may include redness, itching, pain, or cracks in the skin. Treatment depends on the cause.

MalaCards based summary : Vulvar Disease, also known as vulvar diseases, is related to vulvar dystrophy and vulvitis, and has symptoms including pelvic pain and pruritus vulvae. An important gene associated with Vulvar Disease is CDKN2A (Cyclin Dependent Kinase Inhibitor 2A), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. The drugs Acetylcholine and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include lymph node, skin and cervix, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Disease Ontology : ¹² A female reproductive system diseaes that is located in the vulva.

Wikipedia : ⁷⁷ A vulvar disease is a particular abnormal, pathological condition that affects part or all of the vulva.... more...

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Related Diseases for Vulvar Disease

Diseases related to Vulvar Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 183)

#	Related Disease	Score	Top Affiliating Genes
1	vulvar dystrophy	31.8	CDKN2A LINC01191
2	vulvitis	31.6	KRT7 LINC01191
3	vulvar intraepithelial neoplasia	30.1	KRT7 TP53
4	in situ carcinoma	29.8	CDKN2A EGFR TP53
5	ulceration of vulva	11.0
6	atrophic vulva	11.0
7	cervix small cell carcinoma	10.5	CDKN2A TP53
8	cystic teratoma	10.4	KRT7 TP53
9	epithelial-myoepithelial carcinoma	10.4	KRT7 TP53
10	inverted transitional papilloma	10.4	CDKN2A KRT7
11	bladder squamous cell carcinoma	10.4	CDKN2A TP53
12	keratinizing squamous cell carcinoma	10.4	CDKN2A TP53
13	spitz nevus	10.4	CDKN2A TP53
14	malignant spiradenoma	10.4	KRT7 TP53
15	spiradenoma	10.4	KRT7 TP53
16	scrotal carcinoma	10.4	CDKN2A TP53
17	adenoid basal cell carcinoma	10.4	CDKN2A KRT7
18	bile duct adenoma	10.4	CDKN2A KRT7
19	endocervical carcinoma	10.4	CDKN2A KRT7
20	thyroid lymphoma	10.4	CDKN2A TP53
21	nasal cavity cancer	10.4	CDKN2A KRT7
22	bartholin's gland disease	10.4	CDKN2A TP53
23	anal squamous cell carcinoma	10.4	CDKN2A TP53
24	megaesophagus	10.4	CDKN2A TP53
25	gastric adenosquamous carcinoma	10.4	CDKN2A TP53
26	papillary serous adenocarcinoma	10.3	KRT7 TP53
27	anogenital venereal wart	10.3	CDKN2A TP53
28	anal canal carcinoma	10.3	CDKN2A KRT7
29	female reproductive endometrioid cancer	10.3	KRT7 TP53
30	horseshoe kidney	10.3	EGFR KRT7
31	renal pelvis transitional cell carcinoma	10.3	KRT7 UPK3A
32	non-invasive bladder papillary urothelial neoplasm	10.3	TP53 UPK3A
33	prostate squamous cell carcinoma	10.3	KRT7 TP53
34	meningeal melanomatosis	10.3	CDKN2A TP53
35	invasive bladder transitional cell carcinoma	10.3	TP53 UPK3A
36	glandular cystitis	10.3	KRT7 UPK3A
37	mucinous bronchioloalveolar adenocarcinoma	10.3	CDKN2A KRT7
38	brain ependymoma	10.3	EGFR TP53
39	malignant peritoneal mesothelioma	10.3	CDKN2A EGFR
40	peritoneal mesothelioma	10.3	CDKN2A EGFR
41	suppressor of tumorigenicity 3	10.3	CDKN2A TP53
42	well-differentiated liposarcoma	10.3	CDKN2A KRT7
43	anaplastic oligodendroglioma	10.3	CDKN2A EGFR
44	benign breast adenomyoepithelioma	10.3	EGFR KRT7
45	recurrent respiratory papillomatosis	10.3	EGFR TP53
46	breast papillomatosis	10.3	CCND1 CDKN2A
47	oncocytic breast carcinoma	10.3	EGFR KRT7
48	bladder carcinoma in situ	10.3	CDKN2A KRT7 TP53
49	nasal cavity adenocarcinoma	10.3	CDKN2A KRT7 TP53
50	glycogen-rich clear cell breast carcinoma	10.3	CDKN2A KRT7 TP53

Graphical network of the top 20 diseases related to Vulvar Disease:

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Symptoms & Phenotypes for Vulvar Disease

UMLS symptoms related to Vulvar Disease:

pelvic pain, pruritus vulvae

GenomeRNAi Phenotypes related to Vulvar Disease according to GeneCards Suite gene sharing:

²⁷ (show all 22)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-110	9.7	KRT13
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-116	9.7	KRT13
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-118	9.7	EGFR
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-121	9.7	EGFR
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-126	9.7	CCND1
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-152	9.7	CCND1
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-16	9.7	CCND1
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-163	9.7	CCND1
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-177	9.7	CCND1
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-189	9.7	KRT13
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-190	9.7	EGFR
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-199	9.7	CCND1
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-21	9.7	CCND1 EGFR KRT13
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-210	9.7	CCND1
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-214	9.7	EGFR
16	Increased shRNA abundance (Z-score > 2)	GR00366-A-25	9.7	CCND1
17	Increased shRNA abundance (Z-score > 2)	GR00366-A-30	9.7	KRT13
18	Increased shRNA abundance (Z-score > 2)	GR00366-A-36	9.7	CCND1
19	Increased shRNA abundance (Z-score > 2)	GR00366-A-43	9.7	EGFR
20	Increased shRNA abundance (Z-score > 2)	GR00366-A-50	9.7	KRT13
21	Increased shRNA abundance (Z-score > 2)	GR00366-A-81	9.7	KRT13
22	Increased shRNA abundance (Z-score > 2)	GR00366-A-85	9.7	EGFR

Sources

Drugs & Therapeutics for Vulvar Disease

Drugs for Vulvar Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 223)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Acetylcholine

Approved, Investigational

Phase 4,Phase 3,Phase 2

51-84-3

187

Miconazole

Approved, Investigational, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

22916-47-8

4189

Fluconazole

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1

86386-73-4

3365

Clotrimazole

Approved, Vet_approved

Phase 4,Phase 2,Phase 3,Phase 1

23593-75-1

2812

Dequalinium

Approved, Investigational

Phase 4

6707-58-0

Terconazole

Approved

Phase 4,Phase 3,Not Applicable

67915-31-5

441383

Petrolatum

Approved, Investigational

Phase 4,Phase 2,Not Applicable

8009-03-8

Lidocaine

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

137-58-6

3676

Tamoxifen

Approved

Phase 4

10540-29-1

2733526

Tinidazole

Approved, Investigational

Phase 4

19387-91-8

5479

abobotulinumtoxinA

Phase 4,Phase 3,Phase 2

Acetylcholine Release Inhibitors

Phase 4,Phase 3,Phase 2

Botulinum Toxins

Phase 4,Phase 3,Phase 2

Cholinergic Agents

Phase 4,Phase 3,Phase 2

Botulinum Toxins, Type A

Phase 4,Phase 3,Phase 2

Neurotransmitter Agents

Phase 4,Phase 3,Phase 2,Not Applicable

Antifungal Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Steroid Synthesis Inhibitors

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Cytochrome P-450 Enzyme Inhibitors

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Cytochrome P-450 CYP2C9 Inhibitors

Phase 4,Phase 3,Phase 2,Phase 1

Hormones

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Hormone Antagonists

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Anti-Infective Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Cytochrome P-450 CYP2C19 Inhibitors

Phase 4,Phase 3,Phase 2,Phase 1

Estrogens

Phase 4,Phase 2,Not Applicable

Anti-Infective Agents, Local

Phase 4,Phase 3

Cytochrome P-450 CYP3A Inhibitors

Phase 4,Phase 3,Not Applicable

Estrogen Receptor Antagonists

Phase 4

Aromatase Inhibitors

Phase 4

Tea

Phase 4

Estrogen Antagonists

Phase 4

Amitriptyline

Approved

Phase 3

50-48-6

2160

Perphenazine

Approved

Phase 3

58-39-9

4748

Tomato

Approved

Phase 3

Nifedipine

Approved

Phase 3

21829-25-4

4485

Norepinephrine

Approved

Phase 3

51-41-2

439260

Levomilnacipran

Approved, Investigational

Phase 3

96847-54-0

Milnacipran

Approved, Investigational

Phase 3

92623-85-3

65833

Clindamycin

Approved, Vet_approved

Phase 3,Not Applicable

18323-44-9

29029

Butoconazole

Approved

Phase 3,Not Applicable

64872-76-0, 64872-77-1

47472

Ketoconazole

Approved, Investigational

Phase 3

65277-42-1

47576

Tetracycline

Approved, Vet_approved

Phase 3

60-54-8

5353990

Amphotericin B

Approved, Investigational

Phase 3,Phase 2

1397-89-3

5280965 14956

Octreotide

Approved, Investigational

Phase 3

83150-76-9

6400441 383414

Capsaicin

Approved

Phase 2, Phase 3,Phase 1

404-86-4

1548943

Clobetasol

Approved, Experimental, Investigational

Phase 3,Phase 2,Not Applicable

25122-46-7, 25122-41-2

5311051 32798

Cisplatin

Approved

Phase 3,Phase 2,Phase 1

15663-27-1

2767 441203 84093

Calcium

Approved, Nutraceutical

Phase 3,Phase 2

7440-70-2

271

Antipsychotic Agents

Phase 3

Interventional clinical trials:

(show top 50) (show all 241)

#	Name	Status	NCT ID	Phase	Drugs
1	Botox on Vulvar Vestibulitis	Unknown status	NCT00119886	Phase 4	Botulinum toxin
2	Epidemiological Study About the Evolution of Patients Treated for an Acute Episode of Vulvovaginal Candidiasis	Completed	NCT02248506	Phase 4
3	Comparative Efficacy Study of 10 mg Dequalinium Chloride (Fluomizin) in the Treatment of Vulvovaginal Candidiasis	Completed	NCT02242695	Phase 4	Fluomizin vaginal tablets;Canesten vaginal tablets
4	Clotrimazole Vaginal Tablet vs Fluconazole for Severe Vulvovaginal Candidiasis	Completed	NCT02180828	Phase 4	Clotrimazole vaginal tablet;Fluconazole
5	Terconazole Vaginal Suppository vs Fluconazole for the Treatment of Severe Vulvovaginal Candidiasis	Completed	NCT02180100	Phase 4	Terconazole Vaginal Suppository;Fluconazole
6	Effect of Exercise on Spread of the Miconozole Nitrate OVULE in the Vagina	Completed	NCT00194324	Phase 4	Miconazole nitrate
7	Topical Treatment for Sexual Pain, Vulvar Pain, in Postmenopausal Women Not Taking Estrogens or Similiar Hormones. Women on Aromatase Inhibitors or Tamoxifen CAN Enter the Clinical Trial	Recruiting	NCT03682601	Phase 4	Sinecatechins Topical
8	Evaluation of Efficacy and Safety of Gynomax® XL Ovule	Not yet recruiting	NCT03839875	Phase 4	Gynomax® XL Vaginal Ovule
9	Physical Therapy as Adjuvant Treatment of Vulvodynia: a Randomized Controled Trial	Unknown status	NCT02871661	Phase 3	Amitriptyline
10	Dysbiosis in Localized Provoked Vulvodynia (LPV)	Unknown status	NCT02393911	Phase 3
11	Efficacy Study of Topical Application of Nifedipine Cream to Treat Vulvar Vestibulitis	Completed	NCT00496184	Phase 3	Nifedipine cream topical application
12	Savella in Treatment for Provoked Vestibulodynia	Completed	NCT01304589	Phase 3	Milnacipran
13	Vaginal Infection Study	Completed	NCT00616330	Phase 3	clindamycin phosphate/butoconazole nitrate;clindamycin phosphate;butoconazole nitrate
14	Radiation Therapy or Surgery in Treating Patients With Previously Untreated Vulva Cancer With Positive Groin Lymph Nodes	Completed	NCT00898352	Phase 3
15	Prospective and Randomized Study to Evaluate Interest of Ultracision Use in Inguinal Lymph Nodes Curage	Completed	NCT00224744	Phase 3
16	Lymphatic Mapping in Treating Patients With Stage I or Stage II Cancer of the Vulva	Completed	NCT00003325	Phase 3
17	Safety and Immunogenicity Study of V503 (GARDASIL™9, 9vHPV Vaccine) Administered to 9- to 26-Year-Old Females and Males in Vietnam	Completed	NCT03546842	Phase 3
18	Immunogenicity and Tolerability of Broad Spectrum Human Papillomavirus (HPV) Vaccine in Adult and Young Adult Women (V503-004)	Completed	NCT03158220	Phase 3
19	ProF-001_Phase IIa	Completed	NCT03115073	Phase 2, Phase 3	Candiplus;Clotrimazole
20	Therapy to Prevent Sexual Pain in Breast Cancer Survivors	Completed	NCT01539317	Phase 3	Topical liquid lidocaine;Topical saline
21	Study of the Efficacy and Tolerance of Intra-vaginal Treatment With a Total Freeze-dried Culture of Lcr Regenerans® in the Prevention of Relapses of Recurrent Vulvovaginal Candidiasis	Completed	NCT02251093	Phase 3	Lcr Regenerans;Placebo
22	The Study Of Fluconazole For Vulvovaginal Candidiasis	Completed	NCT01806623	Phase 3	Fluconazole
23	A Study to Compare the Efficacy and Safety of a Combination of Ketoconazole and Clindamycin Compared to Tetracycline/Amphotericin B Combination Cream for the Treatment of Bacterial Vaginosis and Vaginal Candidiasis (P08077)	Completed	NCT01293643	Phase 3	100 mg clindamycin /800 mg ketoconazole vaginal ovule;100 mg tetracycline hydrochloride /50 mg amphotericin B cream
24	A Study of V503, a 9-valent Human Papillomavirus (9vHPV) Vaccine in Females 12-26 Years of Age Who Have Previously Received GARDASIL™ (V503-006)	Completed	NCT01047345	Phase 3
25	Comparative Efficacy of Ovule vs Tablet	Completed	NCT00755053	Phase 3	Clotrimazole, vaginal ovule;Clotrimazole, vaginal tablet
26	Broad Spectrum HPV (Human Papillomavirus) Vaccine Study in 16-to 26-Year-Old Women (V503-001)	Completed	NCT00543543	Phase 3
27	Diabetes Mellitus and Vulvovaginal Candidiasis	Completed	NCT00353561	Phase 3	Boric;Fluconazole
28	Octreotide in Preventing Diarrhea in Patients Who Are Undergoing Radiation Therapy to the Pelvis	Completed	NCT00033605	Phase 3	octreotide acetate
29	Fibrin Sealant in Decreasing Lymphedema Following Surgery to Remove Lymph Nodes in Patients With Cancer of the Vulva	Completed	NCT00028951	Phase 3	fibrin sealant
30	A Pilot Study of the Effects of Botulinum Toxin in the Treatment of Provoked Vestibulodynia	Recruiting	NCT02858219	Phase 3	Botulinum Toxin Type A
31	A Study of the Effects of Topical Capsaicin in the Treatment of Provoked Vestibulodynia	Recruiting	NCT02854670	Phase 2, Phase 3	Capsaicin patch
32	Placebo-controlled RCT of Botulinum Toxin A as a Treatment for Provoked Vestibulodynia	Recruiting	NCT02773641	Phase 3	Botulinum Toxin Type A;Sterile Saline Solution
33	Clobetasol Proprionate Versus Fractionated CO2 Laser for the Treatment of Lichen Sclerosus	Recruiting	NCT02573883	Phase 3	Clobetasol Propionate 0.05% ointment
34	Treatment of Candidal Vulvovaginitis Using Cumin Seed Extract Vaginal Cream.	Recruiting	NCT03005353	Phase 2, Phase 3	Cumin seed extract;clotrimazole
35	Efficacy and Safety of Oral Ibrexafungerp (SCY-078) vs. Placebo in Subjects With Acute Vulvovaginal Candidiasis	Recruiting	NCT03734991	Phase 3	Ibrexafungerp;Placebo
36	A Study of Oral VT-1161 for the Treatment of Acute Vaginal Candidiasis (Yeast Infection) in Patients With Recurrent Vaginal Candidiasis	Recruiting	NCT03840616	Phase 3	VT-1161 150 mg capsule;Fluconazole 150 mg
37	A Study of Oral VT-1161 for the Treatment of Patients With Recurrent Vaginal Candidiasis (Yeast Infection)	Recruiting	NCT03562156	Phase 3	VT-1161;Placebo
38	A Study of Oral VT-1161 for the Treatment of Patients With Recurrent Vaginal Candidiasis (Yeast Infection)	Recruiting	NCT03561701	Phase 3	VT-1161;Placebo
39	Fluorescence for Sentinel Lymph Node Identification in Cancer Surgery	Recruiting	NCT02997553	Phase 3	Indocyanine green;Technetium99
40	A Study of V503 (A Multivalent Human Papillomavirus [HPV] L1 Virus-Like Particle [VLP] Vaccine) in Preadolescents and Adolescents (V503-002)	Active, not recruiting	NCT00943722	Phase 3
41	Ketoconazole Gel Versus Terconazole Cream for Vaginal Candidiasis	Not yet recruiting	NCT03473418	Phase 3	Ketoconazole;Terconazole
42	Radiation Therapy With or Without Cisplatin in Treating Patients With Stage I, Stage II, or Stage III Cancer of the Vulva	Terminated	NCT00006096	Phase 3	cisplatin
43	Flexitouch® Home Maintenance Therapy or Standard Home Maintenance Therapy in Treating Patients With Lower-Extremity Lymphedema Caused by Treatment for Cervical Cancer, Vulvar Cancer, or Endometrial Cancer	Terminated	NCT00577317	Phase 3
44	Efficacy, Safety LactiSal 1% Gel, LactSal 50 mg, Clotrimazole 100 mg Tablet in Treatment Vulvovaginal Candidiasis	Withdrawn	NCT02907307	Phase 3	Clotrimazole vaginal tablet 100mg
45	Bioimpedance Spectroscopy in Detecting Lower-Extremity Lymphedema in Patients With Stage I, Stage II, Stage III, or Stage IV Vulvar Cancer Undergoing Surgery and Lymphadenectomy	Unknown status	NCT01406769	Phase 2
46	Nutritional Supplements in Improving Quality of Life During First-Line Chemotherapy in Patients With Metastatic Gynecological Cancer	Unknown status	NCT00905658	Phase 2
47	Phase I/II Randomized, Placebo-Controlled Study of Capsaicin for Interstitial Cystitis and Vulvar Vestibulitis	Completed	NCT00004316	Phase 1, Phase 2	capsaicin
48	Infiltration of the Vestibulum Vaginae With Botulin Toxin in Patients With Localized Provoked Vulvodynia	Completed	NCT01747161	Phase 2	Botulin toxin;physiological water
49	Enoxaparin as Treatment for Vulvodynia	Completed	NCT00874484	Phase 2	Clexane (enoxaparin)
50	CC-10004 For The Treatment Of Vulvodynia	Completed	NCT00814632	Phase 2	CC-10004

Search NIH Clinical Center for Vulvar Disease

Cochrane evidence based reviews: vulvar diseases

Sources

Genetic Tests for Vulvar Disease

Sources

Anatomical Context for Vulvar Disease

MalaCards organs/tissues related to Vulvar Disease:

⁴²

Lymph Node, Skin, Cervix, Testes, Brain, Colon, Tonsil

The Foundational Model of Anatomy Ontology organs/tissues related to Vulvar Disease:

²⁰

The Vulva

Sources

Publications for Vulvar Disease

Articles related to Vulvar Disease:

(show top 50) (show all 68)

#	Title	Authors	Year
1	Comparison of Serum Vitamin D Levels in Relation to Bowel and Bladder Symptoms in Women with Vulvar Diseases. ( 30747611 )	Swenson CW...Berger MB	2019
2	"The Future of Vulvar Disease: New and Ongoing Challenges": Presidential Lecture - XXIV World Congress 2017, Mendoza, Argentina. ( 29474239 )	Marchitelli C	2018
3	Lichenoid vulvar disease: A review. ( 28492056 )	Fruchter R...Pomeranz MK	2017
4	Evaluation and Management of Vulvar Disease. ( 28778648 )	Venkatesan A	2017
5	HPV-related vulvar diseases and perspectives of p16INK4a immunochemistry: a review of the literature. ( 28574130 )	Carrone A...Benedetti Panici P	2017
6	Primary extramammary invasive Paget's vulvar disease: what is the standard, what are the challenges and what is the future for radiotherapy? ( 27473174 )	Tolia M...Kyrgias G	2016
7	What Do Patients Want? A Needs Assessment of Vulvodynia Patients Attending a Vulvar Diseases Clinic. ( 27484917 )	LePage K...Selk A	2016
8	Psychosexual Aspects of Vulvar Disease. ( 26125964 )	Rosenbaum TY...Wilhite M	2015
9	Sexual well-being in patients with vulvar disease: results from a preliminary prospective matched case-control study. ( 26342683 )	Wylomanski S...Qu?reux G	2015
10	Lower Urinary Tract and Functional Bowel Symptoms in Women With Vulvar Diseases and Controls. ( 26052645 )	Swenson CW...Berger MB	2015
11	Paediatric vulvar disease. ( 25134451 )	Simpson RC...Murphy R	2014
12	Effect of the human papillomavirus (HPV) quadrivalent vaccine in a subgroup of women with cervical and vulvar disease: retrospective pooled analysis of trial data. ( 22454089 )	Joura EA...FUTURE I and II Study Group	2012
13	Considerations for disease impact and outcome measures in vulvar disease. ( 22659774 )	Simpson RC...Murphy R	2012
14	Prevalences of and risk factors for vulvar diseases in Nepal: a hospital-based study. ( 21244379 )	Pathak D...Dhali TK	2011
15	The impact of the latest classification system of benign vulvar diseases on the management of women with chronic vulvar pruritus. ( 21508567 )	Kelekci KH...Kelekci S	2011
16	Human papillomavirus infections and vulvar disease development. ( 19505910 )	Garland SM...Joura EA	2009
17	Vulvar diseases of the tropics: a review. ( 19301568 )	Okoduwa C...Heller DS	2009
18	Bladder and bowel symptoms among women with vulvar disease: are they universal? ( 18210896 )	Kennedy CM...Galask RP	2007
19	Vulvar disease pearls. ( 16677963 )	Margesson LJ	2006
20	Vulvar disease update. ( 17249297 )	Werlinger KD...Cockerell CJ	2006
21	Vulvar disease: a pelvic floor pain disorder? ( 15970821 )	Kennedy CM...Galask RP	2005
22	Vulvar disease. ( 12100817 )	Foster DC	2002
23	The serious clinical problem of chronic vulvar disease. ( 12230080 )	Dennerstein G	2002
24	Vulvar disease in children: a clinical audit of 130 cases. ( 10720979 )	Fischer G...Rogers M	2000
25	Adverse behavioral and sexual factors in chronic vulvar disease. ( 10920305 )	Marin MG...Dennerstein GJ	2000
26	Dyspareunia and vulvar disease. ( 9839263 )	Marin MG...Sfameni S	1998
27	Office gynecology for the primary care physician, part II: pelvic pain, vulvar disease, disorders of menstruation, premenstrual syndrome, and breast disease. ( 8614176 )	Klein TA	1996
28	Vulvar disease in the pediatric population. ( 8723821 )	Ridley CM	1996
29	Clinicopathologic analysis of 370 cases of vulvar intraepithelial neoplasia. Italian Study Group on Vulvar Disease. ( 8887191 )		1996
30	Treatment of human papillomavirus-associated vulvar disease with the CO2-laser. Physical and histological aspects with use of a new scanning device, the SwiftLase. ( 8933926 )	Sp?rri S...Dreher E	1996
31	The commonest causes of symptomatic vulvar disease: a dermatologist's perspective. ( 8936065 )	Fischer GO	1996
32	Proceedings of the 11th International Congress of the International Society for the Study of Vulvar Disease. Oxford, England, September 1991. ( 8095071 )		1993
33	International Society for the Study of Vulvar Disease. ( 8441124 )	Ridley CM	1993
34	Advances in vulvar disease: lichen sclerosus et atrophicus et al. ( 1739579 )	Krafchik BR	1992
35	Vulvar diseases. ( 1606758 )		1992
36	General principles in the diagnosis and treatment of vulvar diseases. ( 1606759 )	Turner ML...Marinoff SC	1992
37	Ultrasonic surgical aspiration in the treatment of vulvar disease. ( 1876389 )	Adelson MD	1991
38	Ultrasonic surgical aspiration in the treatment of vulvar disease. ( 2002980 )	Rader JS...Rosenshein NB	1991
39	Proceedings of the 10th International Congress of the International Society for the Study of Vulvar Disease, Washington, D.C., October 1989. ( 1980515 )		1990
40	Proceedings of the Tenth World Congress of the International Society for the Study of Vulvar Disease, Washington, D.C., October 22-26, 1989. ( 1980928 )		1990
41	Superficial laser vulvectomy. IV. Extended laser vaporization and adjunctive 5-fluorouracil therapy of human papillomavirus-associated vulvar disease. ( 2166264 )	Reid R...Stoler M	1990
42	Surgical-procedure terminology for the vulva and vagina. Report of an International Society for the Study of Vulvar Disease Task Force. ( 2277365 )		1990
43	The 1989 presidential address. International Society for the Study of Vulvar Disease. ( 2277371 )	Wilkinson EJ	1990
44	New nomenclature for vulvar disease. Report of the Committee on Terminology of the International Society for the Study of Vulvar Disease. ( 2352242 )		1990
45	A critique of current classifications of vulvar diseases. ( 2203271 )	Kiryu H...Ackerman AB	1990
46	New nomenclature for vulvar disease: International Society for the Study of Vulvar Disease. ( 2707802 )	Ridley CM...Lynch PJ	1989
47	Proceedings of the ninth world congress of the International Society for the Study of Vulvar Disease. Queensland, Australia, September 1987. ( 3172073 )		1988
48	International Society for the Study of Vulvar Disease--progress report. ( 3395571 )	Ridley CM	1988
49	Proceedings of the Eighth World Congress of the International Society for the Study of Vulvar Disease. Mariehamn, Finland, September 9-15, 1985. ( 3772896 )		1986
50	Selected ISSVD (International Society for the Study of Vulvar Disease) abstracts. ( 3783540 )		1986

Sources

Genes for Vulvar Disease

Genes related to Vulvar Disease (0 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	16.46	DISEASES inferred ¹⁵
2	TP53	Tumor Protein P53	Protein Coding	16.07	DISEASES inferred ¹⁵
3	KRT7	Keratin 7	Protein Coding	15.09	DISEASES inferred ¹⁵
4	KRT13	Keratin 13	Protein Coding	15.06	DISEASES inferred ¹⁵
5	PLXDC2	Plexin Domain Containing 2	Protein Coding	14.56	DISEASES inferred ¹⁵
6	SCN10A	Sodium Voltage-Gated Channel Alpha Subunit 10	Protein Coding	14.47	DISEASES inferred ¹⁵
7	UPK3A	Uroplakin 3A	Protein Coding	14.25	DISEASES inferred ¹⁵
8	EGFR	Epidermal Growth Factor Receptor	Protein Coding	14.19	DISEASES inferred ¹⁵
9	CCND1	Cyclin D1	Protein Coding	14.15	DISEASES inferred ¹⁵
10	LINC01191	Long Intergenic Non-Protein Coding RNA 1191	RNA Gene	8.69	DISEASES inferred ¹⁵
11	MIR3147	MicroRNA 3147	RNA Gene	5.62	DISEASES inferred ¹⁵
12	GP5	Glycoprotein V Platelet	Protein Coding	4.95	DISEASES inferred ¹⁵

Sources

Variations for Vulvar Disease

Sources

Expression for Vulvar Disease

Search GEO for disease gene expression data for Vulvar Disease.

Sources

Pathways for Vulvar Disease

Pathways related to Vulvar Disease according to GeneCards Suite gene sharing:

(show all 16)

#	Super pathways	Score	Top Affiliating Genes
1	Endometrial cancer ³⁸ Show member pathways Acute myeloid leukemia ³⁸ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁷ Chronic myeloid leukemia ³⁸ Colorectal cancer ³⁸ Pancreatic cancer ³⁸ Prostate cancer ³⁸ Signal transduction PTEN pathway ²³ Thyroid cancer ³⁸	12.6	CCND1 CDKN2A EGFR TP53
2	Pathways in cancer ³⁸	12.56	CCND1 CDKN2A EGFR TP53
3	Gastric cancer ³⁸ Show member pathways Breast cancer ³⁸ Hepatocellular carcinoma ³⁸	12.4	CCND1 CDKN2A EGFR TP53
4	Glioma ³⁸ Show member pathways Endocrine resistance ³⁸ Melanoma ³⁸ Non-small cell lung cancer ³⁸ Signaling Pathways in Glioblastoma ¹	12.39	CCND1 CDKN2A EGFR TP53
5	MicroRNAs in cancer ³⁸	12.03	CCND1 CDKN2A EGFR TP53
6	Colorectal Cancer Metastasis ⁶⁵	11.92	CCND1 EGFR TP53
7	Cellular senescence (KEGG) ³⁸	11.89	CCND1 CDKN2A TP53
8	AKT Signaling Pathway ⁶⁸	11.88	CCND1 EGFR TP53
9	Integrated Breast Cancer Pathway ¹	11.77	CCND1 EGFR TP53
10	Spinal Cord Injury ¹	11.62	CCND1 EGFR TP53
11	DNA Damage Response (only ATM dependent) ¹	11.56	CCND1 CDKN2A TP53
12	Glioblastoma Multiforme ⁶⁵	11.5	CCND1 CDKN2A EGFR TP53
13	Photodynamic therapy-induced AP-1 survival signaling. ¹	10.96	CCND1 CDKN2A EGFR TP53
14	Bladder cancer ¹ ³⁸	10.88	CCND1 CDKN2A EGFR TP53 UPK3A
15	Inhibition of Ribosome Biogenesis by p14(ARF) ⁶⁵	10.82	CDKN2A TP53
16	TP53 Network ¹ Show member pathways Activation, translocation and oligomerization of BAX ⁶⁷	10.8	CDKN2A TP53

Sources

GO Terms for Vulvar Disease

Biological processes related to Vulvar Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	replicative senescence	GO:0090399	9.26	CDKN2A TP53
2	positive regulation of production of miRNAs involved in gene silencing by miRNA	GO:1903800	9.16	EGFR TP53
3	mitotic G1 DNA damage checkpoint	GO:0031571	8.96	CCND1 TP53
4	response to UV-A	GO:0070141	8.62	CCND1 EGFR

Molecular functions related to Vulvar Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein kinase binding	GO:0019901	8.92	CCND1 CDKN2A EGFR TP53

Sources

Sources for Vulvar Disease

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia