MCID: VLV015
MIFTS: 31

Vulvar Dystrophy

Categories: Reproductive diseases

Aliases & Classifications for Vulvar Dystrophy

MalaCards integrated aliases for Vulvar Dystrophy:

Name: Vulvar Dystrophy 12 15
Dystrophy of Vulva 12 70

Classifications:



External Ids:

Disease Ontology 12 DOID:14292
ICD9CM 34 624.0
NCIt 50 C34565
SNOMED-CT 67 198378001
ICD10 32 N90.4
UMLS 70 C0013426

Summaries for Vulvar Dystrophy

Disease Ontology : 12 A vulvar disease that is characterized as irregular patchy areas of thickened skin and severe itching.

MalaCards based summary : Vulvar Dystrophy, also known as dystrophy of vulva, is related to vulva cancer and squamous cell papilloma. An important gene associated with Vulvar Dystrophy is PGR (Progesterone Receptor), and among its related pathways/superpathways are Degradation of the extracellular matrix and Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include breast, cervix and lung, and related phenotype is integument.

Related Diseases for Vulvar Dystrophy

Diseases related to Vulvar Dystrophy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 162)
# Related Disease Score Top Affiliating Genes
1 vulva cancer 30.4 ZNF652 TP53 KRT13 CDKN2A
2 squamous cell papilloma 30.4 TP53 CDKN2A
3 vulvar intraepithelial neoplasia 30.2 TP53 CDKN2A
4 keratosis 30.2 TP53 KRT17 CDKN2A
5 vulva squamous cell carcinoma 30.1 ZNF652 TP53 CDKN2A
6 lichen planus 29.5 TP53 KRT13 DST COL17A1 CD1A
7 breast leiomyoma 10.4 PGR CD34
8 pulmonary vein leiomyosarcoma 10.4 PGR CD34
9 lung meningioma 10.4 PGR CD34
10 mucocele of appendix 10.4 PGR CD34
11 bartholin's gland adenoma 10.4 TP53 PGR
12 bartholin's gland benign neoplasm 10.4 TP53 PGR
13 vestibular gland benign neoplasm 10.4 TP53 PGR
14 peritoneal benign neoplasm 10.4 PGR CD34
15 polyp of corpus uteri 10.4 PGR MBP
16 basaloid lung carcinoma 10.4 TP53 PGR
17 endometrial squamous cell carcinoma 10.4 PGR CDKN2A
18 liver leiomyoma 10.4 PGR CD34
19 prostate sarcoma 10.4 PGR CD34
20 cervical polyp 10.4 PGR CD34
21 apocrine adenosis of breast 10.4 TP53 PGR
22 small intestine leiomyoma 10.4 MBP CD34
23 intravenous leiomyomatosis 10.4 PGR CD34
24 lichen planus pemphigoides 10.4 DST COL17A1
25 pemphigoid 10.4 DST COL17A1
26 benign pleural mesothelioma 10.4 TP53 CD34
27 multifocal osteogenic sarcoma 10.4 TP53 CD34
28 endometrial mucinous adenocarcinoma 10.3 PGR CDKN2A
29 vaginal endometrial stromal sarcoma 10.3 PGR CD34
30 vulvar leiomyoma 10.3 PGR CD34
31 pediatric angiosarcoma 10.3 TP53 CD34
32 middle ear squamous cell carcinoma 10.3 CDKN2A CD34
33 comedo carcinoma 10.3 TP53 PGR
34 pediatric liposarcoma 10.3 TP53 CD34
35 breast hemangioma 10.3 TP53 CD34
36 pleomorphic lipoma 10.3 PGR CD34
37 neurotic excoriation 10.3 DST COL17A1
38 linear iga disease 10.3 DST COL17A1
39 intracranial meningioma 10.3 PGR CDKN2A
40 pompholyx 10.3 DST COL17A1
41 inflammatory liposarcoma 10.3 CDKN2A CD34
42 esophagus verrucous carcinoma 10.3 TP53 CDKN2A
43 prostate stromal sarcoma 10.3 PGR CD34
44 spitz nevus 10.3 TP53 CDKN2A
45 lichen sclerosus et atrophicus 10.3
46 vagina sarcoma 10.3 PGR CD34
47 glandular cystitis 10.3 TP53 KRT13
48 myoma 10.3 TP53 PGR CD34
49 infiltrating angiolipoma 10.3 CDKN2A CD34
50 breast sarcoma 10.3 TP53 PGR CD34

Comorbidity relations with Vulvar Dystrophy via Phenotypic Disease Network (PDN):


Vulva Cancer

Graphical network of the top 20 diseases related to Vulvar Dystrophy:



Diseases related to Vulvar Dystrophy

Symptoms & Phenotypes for Vulvar Dystrophy

MGI Mouse Phenotypes related to Vulvar Dystrophy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.28 CD109 CD34 CDKN2A HSPG2 IGFBP3 KRT17

Drugs & Therapeutics for Vulvar Dystrophy

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Clinical Study of the CO2RE® Laser Device for Treatment of Vulvar Lichen Sclerosus Completed NCT04148651

Search NIH Clinical Center for Vulvar Dystrophy

Genetic Tests for Vulvar Dystrophy

Anatomical Context for Vulvar Dystrophy

MalaCards organs/tissues related to Vulvar Dystrophy:

40
Breast, Cervix, Lung, Prostate, Thymus, Small Intestine, Liver

Publications for Vulvar Dystrophy

Articles related to Vulvar Dystrophy:

(show top 50) (show all 64)
# Title Authors PMID Year
1
Etiology, Clinical Features, and Diagnosis of Vulvar Lichen Sclerosus: A Scoping Review. 61
32373174 2020
2
The Use of Human Adipose-Derived Stem Cells in the Treatment of Physiological and Pathological Vulvar Dystrophies. 61
26880944 2016
3
The effect of hyaluronic acid (Cicatridine) on healing and regeneration of the uterine cervix and vagina and vulvar dystrophy therapy. 61
21446328 2011
4
High-intensity focused ultrasound treatment for non-neoplastic epithelial disorders of the vulva. 61
20153858 2010
5
[Vulvar dystrophy--morphological, clinical and therapeutical aspects]. 61
20198763 2009
6
[The expression of p16(INK4a) and Ki-67 in atrophic-hyperplastic and dysdysplastic lesions of the vulva]. 61
20198771 2009
7
In defense of Jeffcoate and Woodcock and their "vulvar dystrophy" terminology: the 2006 ISSVD presidential address. 61
17286060 2007
8
Focused ultrasound therapy of vulvar dystrophies: a feasibility study. 61
15516378 2004
9
[Evaluation of white lesions of vulva treated with focused ultrasound]. 61
15312319 2004
10
[Study on the risk factors of 100 cases with vulvar dystrophy]. 61
14575612 2003
11
[Relationship between vulvar dystrophy, malignant tumor and the estrogen progestin receptor]. 61
12515151 2000
12
Clinical observation on electrothermal acupuncture in treatment of 16 cases of vulvar dystrophy. 61
10921135 1999
13
Abnormal expression or mutation of TP53 and HPV in vulvar cancer. 61
10448303 1999
14
Squamous cell carcinoma of the vulva in association with mixed vulvar dystrophy. A brief report with review of literature. 61
9491669 1997
15
Non-neoplastic epithelial alterations of the vulva: recognition assessment and comparisons of terminologies used among the various specialties. 61
9160302 1997
16
Vulvar dystrophy: an evaluation of 285 cases. 61
9105866 1997
17
Human papilloma virus, vulvar dystrophy, and vulvar carcinoma: differential expression of human papillomavirus and vulvar dystrophy in the presence and absence of squamous cell carcinoma of the vulva. 61
8641610 1996
18
Vulvar squamous cell carcinoma. 61
8723825 1996
19
[Modern approach to classification of precancerous conditions and vulvar dystrophy]. 61
8643054 1995
20
[Electron microscope observation on chronic vulvar dystrophy and vulvar carcinoma]. 61
7896259 1994
21
[Gynecologic interventions in the 10th decade of life]. 61
8088488 1994
22
[Lichen sclerosus in girls--risk group for development of vulvar neoplasms in women]. 61
8375705 1993
23
[A case of vulvar dystrophy in a 18-year old patient lasting from her 10th-year of life]. 61
8375706 1993
24
[Vulvar lichen sclerosus]. 61
7951619 1993
25
Epidemiology and etiology of squamous cell carcinoma of the vulva. 61
8387937 1993
26
Vulvar dystrophy: a clinical follow-up. 61
1449423 1992
27
[The results of a selective program to detect intraepithelial neoplasms of the vulva]. 61
1563642 1992
28
[Vulvar dystrophy]. 61
1466686 1992
29
[Pathomorphological studies on vulvar dystrophy]. 61
1782694 1991
30
[Vulvar dystrophies and intraepithelial neoplasms]. 61
1852295 1991
31
[Diagnosis and therapy of vulvar dystrophy]. 61
1790934 1991
32
[Therapeutic proposals in vulvar dystrophy and burning vulva]. 61
2089291 1990
33
A critique of current classifications of vulvar diseases. 61
2203271 1990
34
[Vulvar dystrophy]. 61
2199858 1990
35
[Female urethral stenosis caused by vulvar dystrophy]. 61
2200351 1990
36
[Vulvar dystrophies]. 61
2152519 1990
37
Vulvar dystrophies: an evaluation. 61
2604657 1989
38
Detection of human papillomavirus deoxyribonucleic acid from vulvar dystrophies and vulvar intraepithelial neoplastic lesions. 61
2839984 1988
39
Vulvar dystrophies in young and premenopausal women. 61
3404518 1988
40
Cellular atypia in vulvar dystrophies. 61
3404515 1988
41
Malignant potential of mixed vulvar dystrophy (lichen sclerosus associated with squamous cell hyperplasia). 61
3404517 1988
42
[The measurement of plasma-free testosterone in normal menstrual females, pregnant females, post menopausal females and vulvar dystrophy]. 61
3208920 1988
43
[Treatment of vulvar dystrophy mainly with electrothermo-acupuncture]. 61
3260138 1988
44
Sjögren's syndrome and vulvar cancer. 61
3815841 1987
45
[Diagnosis of vulvar dystrophy]. 61
3808439 1986
46
Vulvar dystrophies. 61
3720066 1986
47
[Oral treatment of vulvar dystrophy with an aromatic retinoid, etretinate]. 61
3710121 1986
48
Vulvar dystrophy. 61
3987128 1985
49
Hormonal receptors in vulvar tissues. 61
4029196 1985
50
Topical testosterone propionate in the therapy of vulvar dystrophies. 61
6698055 1984

Variations for Vulvar Dystrophy

Expression for Vulvar Dystrophy

Search GEO for disease gene expression data for Vulvar Dystrophy.

Pathways for Vulvar Dystrophy

Pathways related to Vulvar Dystrophy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.01 VTN HSPG2 DST COL17A1 A2M
2 11.31 IGFBP3 HSPG2 CD34
3 10.95 VTN TP53 IGFBP3 CDKN2A

GO Terms for Vulvar Dystrophy

Cellular components related to Vulvar Dystrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.92 VTN IGFBP3 HSPG2 ECM1 COL17A1 CD1A
2 extracellular region GO:0005576 9.91 VTN IGFBP3 HSPG2 ECM1 COL17A1 CD34
3 basement membrane GO:0005604 9.54 HSPG2 DST COL17A1
4 cell periphery GO:0071944 9.33 MBP KRT17 CD34
5 collagen-containing extracellular matrix GO:0062023 9.02 VTN HSPG2 ECM1 COL17A1 A2M
6 hemidesmosome GO:0030056 8.96 DST COL17A1

Biological processes related to Vulvar Dystrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-matrix adhesion GO:0007160 9.43 VTN COL17A1 CD34
2 negative regulation of blood coagulation GO:0030195 9.16 VTN CD34
3 hemidesmosome assembly GO:0031581 8.96 DST COL17A1
4 paracrine signaling GO:0038001 8.62 PGR CD34

Molecular functions related to Vulvar Dystrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.13 ZNF652 WDR11 VTN TP53 PGR MBP
2 MDM2/MDM4 family protein binding GO:0097371 8.96 TP53 CDKN2A
3 protease binding GO:0002020 8.92 TP53 MBP ECM1 A2M

Sources for Vulvar Dystrophy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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