MCID: VLV044
MIFTS: 41

Vulvar Intraepithelial Neoplasia

Categories: Reproductive diseases, Rare diseases

Aliases & Classifications for Vulvar Intraepithelial Neoplasia

MalaCards integrated aliases for Vulvar Intraepithelial Neoplasia:

Name: Vulvar Intraepithelial Neoplasia 59
Vulval Intraepithelial Neoplasia 73
Vulvar Intraepithelial Tumor 59

Classifications:



External Ids:

Orphanet 59 ORPHA137583
ICD10 via Orphanet 34 D07.1
UMLS via Orphanet 74 C0346210
UMLS 73 C0346210

Summaries for Vulvar Intraepithelial Neoplasia

MalaCards based summary : Vulvar Intraepithelial Neoplasia, also known as vulval intraepithelial neoplasia, is related to vulva cancer and squamous cell carcinoma, and has symptoms including pruritus and macule. An important gene associated with Vulvar Intraepithelial Neoplasia is TP53 (Tumor Protein P53), and among its related pathways/superpathways are Endometrial cancer and Glioma. The drugs Imiquimod and Aluminum hydroxide have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and cervix.

Wikipedia : 76 Vulvar intraepithelial neoplasia (VIN) refers to particular changes that can occur in the skin that... more...

Related Diseases for Vulvar Intraepithelial Neoplasia

Diseases related to Vulvar Intraepithelial Neoplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 112)
# Related Disease Score Top Affiliating Genes
1 vulva cancer 11.5
2 squamous cell carcinoma 10.7
3 bladder transitional cell papilloma 10.5 BIRC5 TP53
4 cervical carcinosarcoma 10.5 BIRC5 TP53
5 cervicitis 10.4
6 keratocystic odontogenic tumor 10.4 BIRC5 TP53
7 cerebral convexity meningioma 10.4 CDH1 TP53
8 lichen sclerosus 10.4
9 signet ring cell adenocarcinoma 10.3 CDH1 TP53
10 papillary adenocarcinoma 10.3 CDH1 TP53
11 bile duct adenocarcinoma 10.3 CDH1 TP53
12 gastrointestinal system benign neoplasm 10.3 CDH1 TP53
13 intestinal benign neoplasm 10.3 CDH1 TP53
14 pharynx cancer 10.3 CDH1 TP53
15 malignant spiradenoma 10.3 KRT5 TP53
16 actinic keratosis 10.3 MMP2 TP53
17 keratinizing squamous cell carcinoma 10.3 KRT5 TP53
18 ovarian serous cystadenocarcinoma 10.3 BIRC5 TP53
19 serous cystadenocarcinoma 10.3 MMP2 TP53
20 sarcomatoid squamous cell skin carcinoma 10.3 KRT5 TP53
21 breast squamous cell carcinoma 10.3 KRT5 TP53
22 schneiderian carcinoma 10.3 KRT5 TP53
23 cholecystitis 10.3 CDH1 TP53
24 anaplastic thyroid cancer 10.3 CDH1 TP53
25 epidural neoplasm 10.3 KRT5 TP53
26 familial colorectal cancer 10.3 CDH1 TP53
27 prostate squamous cell carcinoma 10.3 KRT5 TP53
28 microcystic meningioma 10.3 CDH1 MMP2
29 cervical squamous cell carcinoma 10.2 CDH1 TP53
30 mixed cell type cancer 10.2 KRT5 TP53
31 necrotizing sialometaplasia 10.2 KRT5 TP53
32 grade iii astrocytoma 10.2 MMP2 TP53
33 optic nerve neoplasm 10.2 KRT5 TP53
34 lung giant cell carcinoma 10.2 CDH1 MMP2
35 hidradenocarcinoma 10.2 KRT5 TP53
36 male reproductive organ cancer 10.2 CDH1 TP53
37 sweat gland cancer 10.2 KRT5 TP53
38 colorectal adenocarcinoma 10.2 CDH1 TP53
39 salivary gland cancer 10.2 BIRC5 MMP2
40 vaginitis 10.2
41 bile duct carcinoma 10.2 CDH1 TP53
42 oral submucous fibrosis 10.2 CDH1 MMP2
43 chordoma 10.2 CDH1 TP53
44 esophageal adenosquamous carcinoma 10.2 CDH1 KRT5
45 breast cystic hypersecretory carcinoma 10.2 CDH1 KRT5
46 adenosquamous carcinoma 10.2 KRT5 TP53
47 oral cavity cancer 10.2 CDH1 TP53
48 breast adenomyoepithelioma 10.1 CDH1 KRT5
49 breast myoepithelial neoplasm 10.1 CDH1 KRT5
50 lymphoepithelioma-like carcinoma 10.1 CDH1 KRT5

Graphical network of the top 20 diseases related to Vulvar Intraepithelial Neoplasia:



Diseases related to Vulvar Intraepithelial Neoplasia

Symptoms & Phenotypes for Vulvar Intraepithelial Neoplasia

UMLS symptoms related to Vulvar Intraepithelial Neoplasia:


pruritus, macule

Drugs & Therapeutics for Vulvar Intraepithelial Neoplasia

Drugs for Vulvar Intraepithelial Neoplasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Imiquimod Approved, Investigational Phase 2, Phase 3,Phase 3 99011-02-6 57469
2
Aluminum hydroxide Approved, Investigational Phase 3 21645-51-2
3
Aluminum sulfate Approved Phase 3 10043-01-3
4 interferons Phase 2, Phase 3,Phase 3
5 Adjuvants, Immunologic Phase 2, Phase 3,Phase 3
6 Vaccines Phase 3,Phase 2,Phase 1
7 Interferon Inducers Phase 2, Phase 3,Phase 3
8 Anesthetics Phase 3
9
Zinc Approved, Investigational Phase 2 7440-66-6 23994
10
Fludarabine Approved Phase 1, Phase 2,Phase 2 21679-14-1, 75607-67-9 30751
11
Omeprazole Approved, Investigational, Vet_approved Phase 2 73590-58-6 4594
12
Cyclophosphamide Approved, Investigational Phase 2,Phase 1 50-18-0, 6055-19-2 2907
13
Indomethacin Approved, Investigational Phase 2 53-86-1 3715
14
Pembrolizumab Approved Phase 1, Phase 2 1374853-91-4
15
Aldesleukin Approved Phase 1, Phase 2 85898-30-2, 110942-02-4
16 Analgesics Phase 2
17 Alkylating Agents Phase 2,Phase 1
18 Gastrointestinal Agents Phase 2
19 Cyclooxygenase Inhibitors Phase 2
20 Analgesics, Non-Narcotic Phase 2
21 Tocolytic Agents Phase 2
22 Antacids Phase 2
23 Peripheral Nervous System Agents Phase 2
24 Vitamins Phase 2
25 Antibodies Phase 1, Phase 2
26 Immunoglobulins Phase 1, Phase 2
27 Antibodies, Monoclonal Phase 1, Phase 2
28 Immunosuppressive Agents Phase 2,Phase 1
29 Anti-Infective Agents Phase 1, Phase 2
30 Anti-HIV Agents Phase 1, Phase 2
31 Anti-Inflammatory Agents Phase 2
32 Proton Pump Inhibitors Phase 2
33 Anti-Retroviral Agents Phase 1, Phase 2
34 Anti-Inflammatory Agents, Non-Steroidal Phase 2
35 Anti-Ulcer Agents Phase 2
36 Antirheumatic Agents Phase 2,Phase 1
37 Antiviral Agents Phase 1, Phase 2
38 Antineoplastic Agents, Alkylating Phase 2,Phase 1

Interventional clinical trials:

(show all 29)
# Name Status NCT ID Phase Drugs
1 Cervical Intraepithelial Neoplasm (CIN)-Warts Efficacy Trial in Women (Gardasil)(V501-013)(COMPLETED) Completed NCT00092521 Phase 3
2 A Randomized Trial of Surgical Treatments for Vulvar and Vaginal Dysplasia Completed NCT00394758 Phase 3
3 ITIC (Imiquimod Therapy in Cervical Intraepithelial Neoplasia)-Trial Completed NCT00941252 Phase 2, Phase 3 Topical imiquimod therapy
4 A Bridging Study of a Recombinant Human Papillomavirus 16/18 Bivalent Vaccine in Preadolescent Girls Completed NCT02562508 Phase 3
5 Broad Spectrum HPV (Human Papillomavirus) Vaccine Study in 16-to 26-Year-Old Women (V503-001) Completed NCT00543543 Phase 3
6 A Study to Evaluate the Safety, Immune Response, and Efficacy of Gardasil (V501, qHPV) in Mid-Adult Women (V501-019) Completed NCT00090220 Phase 3
7 A Study of Gardasil (V501) in Preadolescents and Adolescents (V501-018) Completed NCT00092547 Phase 3
8 Primary Imiquimod Treatment Versus Surgery for Vulvar Intraepithelial Neoplasia Recruiting NCT01861535 Phase 3 Imiquimod
9 Efficacy and Immunogenicity Study of Recombinant Human Papillomavirus Bivalent(Type 16/18 )Vaccine Active, not recruiting NCT01735006 Phase 3
10 Imiquimod Treatment of CIN Lesions Terminated NCT02329171 Phase 3 Imiquimod
11 Immunevasion of Human Papillomavirus (HPV) in Vulvar Intraepithelial Neoplasia 2/3 and Anogenital Warts and Efficiency and Mechanisms of Imiquimod Treatment Completed NCT00941811 Phase 2 Imiquimod
12 Pharmacodynamics, Safety/Tolerability and Efficacy of Topical Omiganan in Patients With uVIN Completed NCT02596074 Phase 2 Omiganan (CLS001) topical gel;Vehicle topical gel
13 The Impact of the "WOMAN-PRO II Program" on Patients With Vulvar Neoplasia to Minimize Post-surgical Symptom Prevalence Completed NCT01986725 Phase 2
14 Dose-Ranging Study of Quadrivalent Human Papillomavirus (HPV) (Types 6,11,16,18) L1 Virus-Like Particle (VLP) Vaccine (V501-007)(COMPLETED) Completed NCT00365716 Phase 2
15 V501 Efficacy Study in Women Aged 18 to 26 (V501-027) Completed NCT00378560 Phase 2
16 IRX-2 Regimen in Treating Women With Cervical Squamous Intraepithelial Neoplasia 3 or Squamous Vulvar Intraepithelial Neoplasia 3 Recruiting NCT03267680 Phase 2 Cyclophosphamide;Indomethacin;Omeprazole
17 Evaluation of VGX-3100 and Electroporation Alone or in Combination With Imiquimod for the Treatment of HPV-16 and/or HPV-18 Related Vulvar HSIL (Also Referred as: VIN 2 or VIN 3) Recruiting NCT03180684 Phase 2 Imiquimod 5% cream
18 E7 TCR T Cells for Human Papillomavirus-Associated Cancers Recruiting NCT02858310 Phase 1, Phase 2 aldesleukin;fludarabine;cyclophosphamide
19 Interest of the Confocal Microscope in the Diagnosis of Epidermoid Carcinoma of the Vulva and Their Precursors Unknown status NCT02735109 Not Applicable
20 A New Patient Reported Outcome Instrument to Assess Symptom Experience in Women With Vulvar Neoplasms (WOMAN-PRO) Unknown status NCT01300663
21 SR-T100 Gel Efficacy & Safety Study for Vulva Pre-cancerous Lesions & Cutaneous Condyloma Completed NCT01676792 Early Phase 1 SR-T100 gel with 2.3% of SM in Solanum undatum plant extract
22 Ultrasonic Aspiration Versus CO2 Laser Ablation for the Treatment of Vulvar Intraepithelial Neoplasia Recruiting NCT02875561 Not Applicable
23 Prevalence of Anal Dysplasia and Anal Cancer in Women With Cervical, Vaginal and Vulvar Dysplasia and Cancer Recruiting NCT02140021 Not Applicable
24 Immuno-persistence Study of a Recombinant Human Papillomavirus 16/18 Bivalent Vaccine in Preadolescent Girls Active, not recruiting NCT03206255
25 Evaluation of Long-term HPV Vaccine Efficacy Enrolling by invitation NCT01393470
26 Screening for Anal Cancer in Women With High-grade Vulvar Dysplasia or Vulvar Cancer. Not yet recruiting NCT03061435 Not Applicable
27 OCT-AF Imaging of Pre-cancers of Vulva and Cervix Not yet recruiting NCT03285841
28 Evaluation of the Role of Vibrational Spectroscopy in the Assessment of Vulval Disease Suspended NCT02223975
29 Colposcopy and High Resolution Anoscopy in Screening For Anal Dysplasia in Patients With Cervical, Vaginal, or Vulvar Dysplasia or Cancer Withdrawn NCT01313104 Not Applicable

Search NIH Clinical Center for Vulvar Intraepithelial Neoplasia

Genetic Tests for Vulvar Intraepithelial Neoplasia

Anatomical Context for Vulvar Intraepithelial Neoplasia

MalaCards organs/tissues related to Vulvar Intraepithelial Neoplasia:

41
Skin, T Cells, Cervix, Testes, Endothelial, Nk Cells, Lung

Publications for Vulvar Intraepithelial Neoplasia

Articles related to Vulvar Intraepithelial Neoplasia:

(show top 50) (show all 249)
# Title Authors Year
1
Vulvar intraepithelial neoplasia: Risk factors for recurrence. ( 29126556 )
2018
2
Differential expression patterns of GATA3 in usual and differentiated types of vulvar intraepithelial neoplasia: potential diagnostic implications. ( 29434343 )
2018
3
Vulvar intraepithelial neoplasia and vulvar squamous cell carcinoma: differential dermoscopic features in a case series, and a progression model. ( 29315730 )
2018
4
Differentiated Vulvar Intraepithelial Neoplasia-like and Lichen Sclerosus-like Lesions in HPV-associated Squamous Cell Carcinomas of the Vulva. ( 29505429 )
2018
5
Classic Vulvar Intraepithelial Neoplasia With Superimposed Lichen Simplex Chronicus: A Unique Variant Mimicking Differentiated Vulvar Intraepithelial Neoplasia. ( 29750709 )
2018
6
The Role of Photodynamic Therapy in the Treatment of Vulvar Intraepithelial Neoplasia. ( 29393881 )
2018
7
Normalizers for microRNA quantification in plasma of patients with vulvar intraepithelial neoplasia lesions and vulvar carcinoma. ( 29299981 )
2017
8
Yield of Cytology Surveillance After High-Grade Vulvar Intraepithelial Neoplasia or Cancer. ( 28644191 )
2017
9
HPV-independent Differentiated Vulvar Intraepithelial Neoplasia (dVIN) is Associated With an Aggressive Clinical Course. ( 28319571 )
2017
10
Dermoscopic features of pigmented vulvar intraepithelial neoplasia. ( 28940726 )
2017
11
Committee Opinion No. 675: Management of Vulvar Intraepithelial Neoplasia: Correction. ( 28092302 )
2017
12
Papillomavirus genotyping on formaldehyde fixed paraffin-embedded tissues in vulvar intraepithelial neoplasia. ( 28795241 )
2017
13
Decreased NK cell activity after partial vulvectomy in pregnant patient with vulvar intraepithelial neoplasia 3 (VIN3). ( 28954490 )
2017
14
HPV16 E7 DNA tattooing: safety, immunogenicity, and clinical response in patients with HPV-positive vulvar intraepithelial neoplasia. ( 28451790 )
2017
15
Imiquimod cream and C02 laser vaporization in vulvar intraepithelial neoplasia (VIN) 2/3 treatment. ( 29693875 )
2017
16
Committee Opinion No.675: Management of Vulvar Intraepithelial Neoplasia. ( 27661656 )
2016
17
Differentiated Vulvar Intraepithelial Neoplasia: What Criteria Do We Use in Practice? ( 27105329 )
2016
18
Committee Opinion No. 675 Summary: Management of Vulvar Intraepithelial Neoplasia. ( 27661648 )
2016
19
Usual-type vulvar intraepithelial neoplasia: report of a case and its dermoscopic features. ( 27419656 )
2016
20
MALDI Mass Spectrometry Imaging Reveals Decreased CK5 Levels in Vulvar Squamous Cell Carcinomas Compared to the Precursor Lesion Differentiated Vulvar Intraepithelial Neoplasia. ( 27399691 )
2016
21
Distinguishing Erosive Lichen Planus From Differentiated Vulvar Intraepithelial Neoplasia. ( 26796658 )
2016
22
Dermoscopic findings of vulvar intraepithelial neoplasia (VIN): a series of 4 cases. ( 27291788 )
2016
23
Assessment of CK17 as a Marker for the Diagnosis of Differentiated Vulvar Intraepithelial Neoplasia. ( 27513074 )
2016
24
Type-specific HPV infection correlates with risk of recurrence of vulvar intraepithelial neoplasia usual type. ( 28006842 )
2016
25
Vulvar intraepithelial neoplasia grade 3 associated with BehAset's disease. ( 26983442 )
2016
26
The Natural History of Vulvar Intraepithelial Neoplasia, Differentiated Type: Evidence for Progression and Diagnostic Challenges. ( 26974999 )
2016
27
Extra-Genital Bowen's Disease on Abdomen Co-existing with Vulvar Intraepithelial Neoplasia. ( 27298533 )
2016
28
Vulvar intraepithelial neoplasia: clinical presentation, management and outcomes in women infected with HIV. ( 26959352 )
2016
29
Medical and Surgical Treatments for Usual-Type Vulvar Intraepithelial Neoplasia. ( 27490514 )
2016
30
Vulvar and Vaginal Cancer, Vulvar Intraepithelial Neoplasia 3 and Vaginal Intraepithelial Neoplasia 3: Experience of a Referral Institute. ( 27430086 )
2016
31
Vulvar Intraepithelial Neoplasia (VIN) and Condylomata. ( 26133495 )
2015
32
Imiquimod in cervical, vaginal and vulvar intraepithelial neoplasia: A review. ( 26335596 )
2015
33
Efficacy of 5% imiquimod cream on vulvar intraepithelial neoplasia in Korea: pilot study. ( 25673934 )
2015
34
LASER VAPORIZATION IN VULVAR INTRAEPITHELIAL NEOPLASIA (VIN), VAGINAL INTRAEPITHELIAL NEOPLASIA (VAIN) AND CONDYLOMATA ACUMINATA: IGCS-0093 Vulvar and Vaginal Cancer. ( 25955950 )
2015
35
No viral association found in a set of differentiated vulvar intraepithelial neoplasia cases by human papillomavirus and pan-viral microarray testing. ( 25894343 )
2015
36
Vulvar intraepithelial neoplasia. ( 25106700 )
2014
37
Expression of coinhibitory receptors on T cells in the microenvironment of usual vulvar intraepithelial neoplasia is related to proinflammatory effector T cells and an increased recurrence-free survival. ( 25220367 )
2014
38
An update on vulvar intraepithelial neoplasia: terminology and a practical approach to diagnosis. ( 24399036 )
2014
39
Surgical treatment of usual type vulvar intraepithelial neoplasia: a study at three academic hospitals. ( 24534242 )
2014
40
Localized amyloidosis of the vulva with and without vulvar intraepithelial neoplasia: report of a series. ( 25149547 )
2014
41
Alterations in classical and nonclassical HLA expression in recurrent and progressive HPV-induced usual vulvar intraepithelial neoplasia and implications for immunotherapy. ( 24415578 )
2014
42
Pathways of vulvar intraepithelial neoplasia and squamous cell carcinoma. ( 23190170 )
2013
43
Treatment of vulvar intraepithelial neoplasia with topical 5% imiquimod cream. ( 23219095 )
2013
44
Treatment of vulvar intraepithelial neoplasia with CO(2) laser vaporization and excision surgery. ( 23609594 )
2013
45
Coexisting high-grade vulvar intraepithelial neoplasia (VIN) and condyloma acuminatum: independent lesions due to different HPV types occurring in immunocompromised patients. ( 23026935 )
2013
46
The use of argon beam coagulation in treating vulvar intraepithelial neoplasia III: a retrospective review. ( 23887037 )
2013
47
Quality of life and female sexual function after skinning vulvectomy with split-thickness skin graft in women with vulvar intraepithelial neoplasia or vulvar Paget disease. ( 24090498 )
2013
48
Immunohistochemical expression of SOX2 in vulvar intraepithelial neoplasia and squamous cell carcinoma. ( 23518916 )
2013
49
Safety and efficacy of topical cidofovir to treat high-grade perianal and vulvar intraepithelial neoplasia in HIV-positive men and women. ( 23032420 )
2013
50
Aberrant staining patterns of E-cadherin and I^-catenin: a potential diagnostic value for distinguishing vulvar intraepithelial neoplasia from non-neoplastic vulvar lesions. ( 23826417 )
2013

Variations for Vulvar Intraepithelial Neoplasia

Expression for Vulvar Intraepithelial Neoplasia

Search GEO for disease gene expression data for Vulvar Intraepithelial Neoplasia.

Pathways for Vulvar Intraepithelial Neoplasia

Pathways related to Vulvar Intraepithelial Neoplasia according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.51 BIRC5 CDH1 TP53
2
Show member pathways
12.38 CDH1 MMP2 TP53
3 12.28 BIRC5 CDH1 MMP2 TP53
4
Show member pathways
12.19 BIRC5 MMP2 TP53
5
Show member pathways
12.09 CDH1 MMP2 TP53
6
Show member pathways
11.56 BIRC5 CDH1 TP53
7 11.49 KRT5 TP53
8 11.48 BIRC5 TP53
9 11.46 CDH1 MMP2
10 11.41 BIRC5 TP53
11 11.39 BIRC5 MMP2 TP53
12
Show member pathways
11.32 BIRC5 MMP2
13 11.22 BIRC5 TP53
14 11.2 MMP2 TP53
15 11.14 BIRC5 CDH1 MMP2 TP53
16 11 CDH1 MMP2 TP53
17 10.97 BIRC5 MMP2
18 10.94 BIRC5 TP53
19 10.81 BIRC5 TP53

GO Terms for Vulvar Intraepithelial Neoplasia

Biological processes related to Vulvar Intraepithelial Neoplasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix disassembly GO:0022617 8.96 CDH1 MMP2
2 cytokine-mediated signaling pathway GO:0019221 8.8 BIRC5 MMP2 TP53

Sources for Vulvar Intraepithelial Neoplasia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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