VIN
MCID: VLV044
MIFTS: 44

Vulvar Intraepithelial Neoplasia (VIN)

Categories: Rare diseases, Reproductive diseases

Aliases & Classifications for Vulvar Intraepithelial Neoplasia

MalaCards integrated aliases for Vulvar Intraepithelial Neoplasia:

Name: Vulvar Intraepithelial Neoplasia 58 17
Vulval Intraepithelial Neoplasia 71
Vulvar Intraepithelial Tumor 58
Vin 58

Classifications:

Orphanet: 58  
Rare gynaecological and obstetric diseases


External Ids:

ICD10 via Orphanet 33 D07.1
UMLS via Orphanet 72 C0346210
Orphanet 58 ORPHA137583
UMLS 71 C0346210

Summaries for Vulvar Intraepithelial Neoplasia

MalaCards based summary : Vulvar Intraepithelial Neoplasia, also known as vulval intraepithelial neoplasia, is related to vulva cancer and vulva squamous cell carcinoma, and has symptoms including pruritus and macule. An important gene associated with Vulvar Intraepithelial Neoplasia is TP53 (Tumor Protein P53), and among its related pathways/superpathways are Metabolism of proteins and Signaling by Rho GTPases. The drugs Imiquimod and Aminolevulinic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and breast, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 74 Vulvar intraepithelial neoplasia (VIN) refers to particular changes that can occur in the skin that... more...

Related Diseases for Vulvar Intraepithelial Neoplasia

Diseases related to Vulvar Intraepithelial Neoplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 247)
# Related Disease Score Top Affiliating Genes
1 vulva cancer 32.9 TP53 CDKN2A
2 vulva squamous cell carcinoma 31.3 TP53 CDKN2A
3 cervix uteri carcinoma in situ 31.2 TP53 CDKN2A
4 cervical intraepithelial neoplasia 31.1 CDKN2A BIRC5
5 vulvar disease 31.0 TP53 CDKN2A
6 anogenital venereal wart 30.8 TP53 CDKN2A
7 papilloma 30.7 TP53 CDKN2A CDH1
8 suppressor of tumorigenicity 3 30.6 TP53 CDKN2A
9 keratinizing squamous cell carcinoma 30.6 TP53 CDKN2A
10 in situ carcinoma 30.5 TP53 CDKN2A CDH1
11 vaginal cancer 30.5 TP53 CDKN2A
12 verrucous carcinoma 30.3 TP53 CDKN2A
13 familial retinoblastoma 30.2 TP53 CDKN2A
14 keratosis, seborrheic 30.1 TP53 CDKN2A
15 leukemia, acute lymphoblastic 3 29.9 TP53 CDKN2A
16 squamous cell carcinoma 29.8 TP53 CTNNB1 CDKN2A CDH1
17 skin carcinoma 29.6 TP53 CDKN2A CDH1
18 lichen sclerosus et atrophicus 10.9
19 squamous cell papilloma 10.7
20 keratosis 10.4
21 neutropenia 10.3
22 immune deficiency disease 10.3
23 bowenoid papulosis 10.3
24 bladder transitional cell papilloma 10.2 TP53 BIRC5
25 mammary paget's disease 10.2
26 lichen planus 10.2
27 48,xyyy 10.2
28 keratocystic odontogenic tumor 10.2 TP53 BIRC5
29 uterine adnexa cancer 10.2 TP53 BIRC5
30 sarcomatoid transitional cell carcinoma 10.2 TP53 CDH1
31 gastric diffuse adenocarcinoma 10.2 TP53 CDH1
32 microglandular adenosis 10.2 TP53 CDH1
33 sarcomatoid renal cell carcinoma 10.2 TP53 CDH1
34 ovarian seromucinous carcinoma 10.1 TP53 CDKN2A
35 thoracic benign neoplasm 10.1 TP53 CDH1
36 spitz nevus 10.1 TP53 CDKN2A
37 breast benign neoplasm 10.1 TP53 CDH1
38 microinvasive gastric cancer 10.1 TP53 CDH1
39 chronic cervicitis 10.1 TP53 CDKN2A
40 oral leukoplakia 10.1 TP53 CDKN2A
41 thyroid lymphoma 10.1 TP53 CDKN2A
42 dedifferentiated liposarcoma 10.1 TP53 CDKN2A
43 familial colorectal cancer 10.1 TP53 CDH1
44 cervical mucinous adenocarcinoma 10.1 TP53 CDKN2A
45 mucinous adenocarcinoma 10.1 TP53 CDKN2A
46 adult astrocytic tumour 10.1 TP53 CDKN2A
47 bladder clear cell adenocarcinoma 10.1 TP53 CDKN2A
48 urethra clear cell adenocarcinoma 10.1 TP53 CDKN2A
49 signet ring cell adenocarcinoma 10.1 TP53 CDH1
50 low-grade astrocytoma 10.1 TP53 CDKN2A

Graphical network of the top 20 diseases related to Vulvar Intraepithelial Neoplasia:



Diseases related to Vulvar Intraepithelial Neoplasia

Symptoms & Phenotypes for Vulvar Intraepithelial Neoplasia

UMLS symptoms related to Vulvar Intraepithelial Neoplasia:


pruritus, macule

GenomeRNAi Phenotypes related to Vulvar Intraepithelial Neoplasia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.53 BIRC5 CDKN2A H2AX TP53
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.53 BIRC5 CDKN2A H2AX TP53

MGI Mouse Phenotypes related to Vulvar Intraepithelial Neoplasia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.91 BIRC5 CDH1 CDKN2A CTNNB1 H2AX TP53
2 endocrine/exocrine gland MP:0005379 9.85 BIRC5 CDH1 CDKN2A CTNNB1 H2AX TP53
3 embryo MP:0005380 9.8 BIRC5 CDH1 CDKN2A CTNNB1 TP53
4 homeostasis/metabolism MP:0005376 9.8 BIRC5 CDH1 CDKN2A CTNNB1 H2AX TP53
5 immune system MP:0005387 9.73 BIRC5 CDH1 CDKN2A CTNNB1 H2AX TP53
6 neoplasm MP:0002006 9.55 CDH1 CDKN2A CTNNB1 H2AX TP53
7 no phenotypic analysis MP:0003012 9.26 CDH1 CDKN2A CTNNB1 TP53
8 reproductive system MP:0005389 9.02 CDH1 CDKN2A CTNNB1 H2AX TP53

Drugs & Therapeutics for Vulvar Intraepithelial Neoplasia

Drugs for Vulvar Intraepithelial Neoplasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 53)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Imiquimod Approved, Investigational Phase 4 99011-02-6 57469
2
Aminolevulinic acid Approved Phase 4 106-60-5 137
3 Adjuvants, Immunologic Phase 4
4 Interferon Inducers Phase 4
5 Immunologic Factors Phase 4
6 interferons Phase 4
7 Pharmaceutical Solutions Phase 4
8 Dermatologic Agents Phase 4
9 Photosensitizing Agents Phase 4
10
Aluminum hydroxide Approved, Investigational Phase 3 21645-51-2
11
Aluminum sulfate Approved Phase 3 10043-01-3
12 Anesthetics Phase 3
13
Zinc Approved, Investigational Phase 2 7440-66-6 32051
14
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
15
Omeprazole Approved, Investigational, Vet_approved Phase 2 73590-58-6 4594
16
Indomethacin Approved, Investigational Phase 2 53-86-1 3715
17
Fludarabine Approved Phase 1, Phase 2 21679-14-1, 75607-67-9 30751
18
Aldesleukin Approved Phase 1, Phase 2 110942-02-4, 85898-30-2
19
Digoxin Approved Phase 2 20830-75-5 30322 2724385
20
Furosemide Approved, Vet_approved Phase 2 54-31-9 3440
21 Anti-Bacterial Agents Phase 2
22 Antimicrobial Cationic Peptides Phase 2
23 Interferon-alpha Phase 1, Phase 2
24 Anti-Infective Agents Phase 1, Phase 2
25 Antiviral Agents Phase 1, Phase 2
26 Gastrointestinal Agents Phase 2
27 Vitamins Phase 2
28 Tocolytic Agents Phase 2
29 Alkylating Agents Phase 2
30 Proton Pump Inhibitors Phase 2
31 Anti-Inflammatory Agents Phase 2
32 Cyclooxygenase Inhibitors Phase 2
33 Anti-Ulcer Agents Phase 2
34 Anti-Inflammatory Agents, Non-Steroidal Phase 2
35 Analgesics, Non-Narcotic Phase 2
36 Immunosuppressive Agents Phase 2
37 Antirheumatic Agents Phase 2
38 Analgesics Phase 2
39 Antacids Phase 2
40 Interleukin-2 Phase 1, Phase 2
41 Anti-Retroviral Agents Phase 1, Phase 2
42 Anti-HIV Agents Phase 1, Phase 2
43 Anti-Arrhythmia Agents Phase 2
44 Natriuretic Agents Phase 2
45 Protective Agents Phase 2
46 Sodium Potassium Chloride Symporter Inhibitors Phase 2
47 diuretics Phase 2
48
Artesunate Approved, Investigational Phase 1 88495-63-0 6917864 5464098
49 Antiparasitic Agents Phase 1
50 Antiprotozoal Agents Phase 1

Interventional clinical trials:

(show all 23)
# Name Status NCT ID Phase Drugs
1 An Exploratory, Open-label Study of Sequential Field-directed Treatment of Actinic Keratoses of the Face With Imiquimod 3.75% Cream Followed by Photodynamic Therapy Terminated NCT01203878 Phase 4 Photodynamic therapy;Imiquimod
2 A Study to Evaluate the Efficacy of Quadrivalent HPV Vaccine in Reducing the Incidence of HPV 6-, 11-, 16-, and 18-Related CIN, AIS, and Cervical Cancer, and HPV 6-, 11-, 16-, and 18-Related External Genital Warts, Vulvar Intraepithelial Neoplasia Vaginal Intraepithelial Neoplasia, Vulvar Cancer, and Vaginal Cancer in 16- to 23-Year-Old Women Completed NCT00092521 Phase 3
3 Comparison of Surgical Procedures in Vulvar and Vaginal Dysplasias Completed NCT00394758 Phase 3
4 Topical Imiquimod in Treating Patients With Grade 2/3 Cervical Intraepithelial Neoplasia Completed NCT00941252 Phase 2, Phase 3 Topical imiquimod therapy
5 Primary Imiquimod Treatment Versus Surgery for Vulvar Intraepithelial Neoplasia Recruiting NCT01861535 Phase 3 Imiquimod
6 A Phase III Multicenter, Randomized, Double-Blind, Placebo(Hepatitis E Vaccine)Controlled Study to Evaluate the Efficacy, Immunogenicity and Safety of a Recombinant(E.Coli)Human Papillomavirus Bivalent Vaccine in Healthy Women Active, not recruiting NCT01735006 Phase 3
7 ITIC2 Trial - Topical Imiquimod Versus Conization to Treat Cervical Intraepithelial Neoplasia: Randomised Controlled, Non-inferiority Trial Terminated NCT01283763 Phase 3 Topical Imiquimod
8 TOPical Imiquimod Treatment of High-grade Cervical Intraepithelial Neoplasm: a Randomized Controlled Trial. Terminated NCT02329171 Phase 3 Imiquimod
9 A Phase 2, Randomized, Double-Blind, Parallel-Group Study to Assess the Pharmacodynamics, Safety/Tolerability and Efficacy of Topical Omiganan in Patients With Usual Type Vulvar Intraepithelial Neoplasia Completed NCT02596074 Phase 2 Omiganan (CLS001) topical gel;Vehicle topical gel
10 An Explorative, Single Center and Controlled Study to Analyze the Immune Escape Mechanisms of HPV-associated Lesions and to Evaluate the Efficiency and Mechanisms of Imiquimod Treatment of Vulvar Intraepithelial Neoplasias 2/3 (VIN) and Anogenital Warts Completed NCT00941811 Phase 2 Imiquimod
11 The Impact of the Self-management Intervention "WOMAN-PRO II Program" on Patients With Vulvar Neoplasia to Minimize Post-surgical Symptom Prevalence: A Mixed-Methods Project Completed NCT01986725 Phase 2
12 Therapeutic Vaccination Against Human Papillomavirus Type 16 for the Treatment of Anal Intraepithelial Neoplasia in HIV+ Men Completed NCT01923116 Phase 1, Phase 2 HPV-16 vaccine
13 A Two-Cohort Randomized Phase 2 Trial of the IRX-2 Regimen in Women With Squamous Cervical Intraepithelial Neoplasia 3 (CIN 3) or Vulvar Intraepithelial Neoplasia 3 (VIN 3) Recruiting NCT03267680 Phase 2 Cyclophosphamide;Indomethacin;Omeprazole
14 A Phase I/II Trial of T Cell Receptor Gene Therapy Targeting HPV-16 E7 With or Without PD-1 Blockade for HPV-Associated Cancers Recruiting NCT02858310 Phase 1, Phase 2 Aldesleukin;Fludarabine;Cyclophosphamide
15 A Phase 2, Randomized, Vehicle-controlled, Double-blind Study to Explore the Efficacy, Pharmacodynamics and Safety of Topical Ionic Contra-viral Therapy (ICVT) Comprised of Digoxin and Furosemide in HPV-induced Genital Lesions of Immunocompromised and Immunocompetent Patients Terminated NCT03334240 Phase 2 CLS003;Vehicle
16 A Phase I Proof-of-Concept Study of Artesunate Ointment for the Treatment of Patients With High-Grade Vulvar Intraepithelial Neoplasia (HSIL VIN 2/3) Recruiting NCT03792516 Phase 1 artesunate ointment 40%
17 Creating and Validating a Patient-reported Outcome Instrument to Assess Symptom Experience Related to Surgical Wounds in Women With Vulvar Neoplasms - A Mixed Methods Study Unknown status NCT01300663
18 Interest of the Confocal Microscope in the Diagnosis of Epidermoid Carcinoma of the Vulva and Their Precursors Unknown status NCT02735109
19 A Pilot Study to Assess the Efficacy & Safety of Topical SR-T100 Gel in the Treatment of Human Vulva Pre-cancerous Lesions (Vulvar Intraepithelial Neoplasia; VIN) & Cutaneous Condyloma(External Genital Warts; EGWs) Completed NCT01676792 Early Phase 1 SR-T100 gel with 2.3% of SM in Solanum undatum plant extract
20 A Double Blind Placebo Controlled Trial of Autologous Platelet Rich Plasma (PRP) Intradermal Injections for the Treatment of Vulvar Lichen Sclerosus Completed NCT03045172 Placebo
21 A Randomized Controlled Trial of Ultrasonic Aspiration Versus CO2 Laser Ablation for the Treatment of Vulvar Intraepithelial Neoplasia Recruiting NCT02875561
22 A Long-term Follow-up Registry-based Cohort Study of HPV Vaccine Efficacy Against Cervical Pre-cancerous Lesions and Cervical Cancers in a Cohort of Females Previously Enrolled From Finland in Study HPV-008, as Compared to a Non-intervention Population -Based Reference Cohort of Females From Finland Enrolling by invitation NCT01393470
23 Evaluation of the Role of Vibrational Spectroscopy in the Assessment of Vulval Disease Suspended NCT02223975

Search NIH Clinical Center for Vulvar Intraepithelial Neoplasia

Genetic Tests for Vulvar Intraepithelial Neoplasia

Anatomical Context for Vulvar Intraepithelial Neoplasia

MalaCards organs/tissues related to Vulvar Intraepithelial Neoplasia:

40
Skin, Lung, Breast, T Cells, Thyroid, Ovary, Tongue

Publications for Vulvar Intraepithelial Neoplasia

Articles related to Vulvar Intraepithelial Neoplasia:

(show top 50) (show all 595)
# Title Authors PMID Year
1
Incorporation of differentiated dysplasia improves prediction of oral leukoplakia at increased risk of malignant progression. 61
31896811 2020
2
The human papillomavirus vaccine as a treatment for human papillomavirus-related dysplastic and neoplastic conditions: A literature review. 61
31085272 2020
3
Vulval squamous cell carcinoma and its precursors. 61
31846523 2020
4
Human papillomavirus genotype distribution in genital warts among women in Harare-Zimbabwe. 61
31790323 2019
5
Nail squamous cell carcinoma: A hidden high-risk human papillomavirus reservoir for sexually transmitted infections. 61
30930083 2019
6
The usefulness of high-frequency ultrasonography in the evaluation of vulvar dermatoses in postmenopausal women - a preliminary report. 61
32021710 2019
7
Vulvar malignancies: an interdisciplinary perspective. 61
31829526 2019
8
Efficacy of a New Therapeutic Option for Vulvar Intraepithelial Neoplasia: Superficial Shaving Combined With Photodynamic Therapy. 61
31709596 2019
9
Long term outcomes in patients with sentinel lymph nodes (SLNs) identified by injecting remaining scar after previously excised vulvar cancer. 61
31451293 2019
10
Recurrence patterns identify aggressive form of human papillomavirus-dependent vulvar cancer. 61
31603537 2019
11
Genital Dysplasia and Immunosuppression: Why Organ-Specific Therapy Is Important. 61
31768388 2019
12
Risk of cervical and vaginal dysplasia after surgery for vulvar intraepithelial neoplasia or cancer: A 6 year follow-up study. 61
31375270 2019
13
Proximal Partial Vaginectomy for Vaginal Intraepithelial Neoplasia. 61
31686750 2019
14
Photodynamic therapy for treatment of usual-type vulvar intraepithelial neoplasia: a case report and literature review. 61
31364444 2019
15
Human Papillomavirus-Independent Squamous Lesions of the Vulva. 61
31097103 2019
16
Differentiated Vulvar Intraepithelial Neoplasia: A Brief Review of Clinicopathologic Features. 61
30640512 2019
17
Clinical and molecular classification of vulvar squamous pre-cancers. 61
30737358 2019
18
Atypical fibroxanthoma associated with differentiated-type vulvar intraepithelial neoplasia: Case report of an unusual entity. 61
31192988 2019
19
Superficially invasive stage IA vulvar squamous cell carcinoma-therapy and prognosis. 61
30622111 2019
20
Classic Vulvar Intraepithelial Neoplasia With Superimposed Lichen Simplex Chronicus: A Unique Variant Mimicking Differentiated Vulvar Intraepithelial Neoplasia. 61
29750709 2019
21
Sec62/Ki67 and p16/Ki67 dual-staining immunocytochemistry in vulvar cytology for the identification of vulvar intraepithelial neoplasia and vulvar cancer: a pilot study. 61
30607586 2019
22
Genital lichen sclerosus et atrophicus in females: An update. 61
31143853 2019
23
The Impact of Focality and Centricity on Vulvar Intraepithelial Neoplasia on Disease Progression in HIV+ Patients: A 10-Year Retrospective Study. 61
31256169 2019
24
Systemic adverse events in imiquimod use for cervical intraepithelial neoplasia - A case series. 61
30906696 2019
25
PD-L1 and IDO expression in cervical and vulvar invasive and intraepithelial squamous neoplasias: implications for combination immunotherapy. 61
30067880 2019
26
Differentiated vulvar intraepithelial neoplasia (dVIN): the most helpful histological features and the utility of cytokeratins 13 and 17. 61
30187167 2018
27
Impact of re-excision of residual adjacent vulvar intraepithelial neoplasia (VIN III) and histological tumour-free margin (hTFM) on survival in primary squamous cell carcinoma of vulva. 61
30187190 2018
28
Molecular heterogeneity in human papillomavirus-dependent and -independent vulvar carcinogenesis. 61
30030907 2018
29
Vulvar intraepithelial neoplasia treated with a combination of surgical excision and laser ablation during pregnancy. 61
30214782 2018
30
Human Papillomavirus Genotypes From Vaginal and Vulvar Intraepithelial Neoplasia in Females 15-26 Years of Age. 61
29995724 2018
31
Differential expression patterns of GATA3 in usual and differentiated types of vulvar intraepithelial neoplasia: potential diagnostic implications. 61
29434343 2018
32
Differentiated Vulvar Intraepithelial Neoplasia-like and Lichen Sclerosus-like Lesions in HPV-associated Squamous Cell Carcinomas of the Vulva. 61
29505429 2018
33
Vulvar intraepithelial neoplasia and vulvar squamous cell carcinoma: differential dermoscopic features in a case series, and a progression model. 61
29315730 2018
34
[Vulvar intraepithelial neoplasia]. 61
29761782 2018
35
Vulvar cancer: Two pathways with different localization and prognosis. 61
29555332 2018
36
Epidermodysplasia Verruciformis-like HPV Infection of the Vulva in Immunosuppressed Women. 61
28700430 2018
37
Is Vulvovaginal Lichen Planus Associated With Squamous Cell Carcinoma? 61
29470358 2018
38
Does Differentiated Squamous Intraepithelial Neoplasia Occur in the Cervix? 61
28877072 2018
39
The Role of Photodynamic Therapy in the Treatment of Vulvar Intraepithelial Neoplasia. 61
29393881 2018
40
Dermoscopic features of pigmented vulvar intraepithelial neoplasia. 61
28940726 2018
41
Accentuated p53 staining in usual type vulvar dysplasia-A potential diagnostic pitfall. 61
29254796 2018
42
Vulvar intraepithelial neoplasia: Risk factors for recurrence. 61
29126556 2018
43
HPV-related vulvar diseases and perspectives of p16INK4a immunochemistry: a review of the literature. 61
28574130 2017
44
Normalizers for microRNA quantification in plasma of patients with vulvar intraepithelial neoplasia lesions and vulvar carcinoma. 61
29299981 2017
45
Final efficacy, immunogenicity, and safety analyses of a nine-valent human papillomavirus vaccine in women aged 16-26 years: a randomised, double-blind trial. 61
28886907 2017
46
HPV-independent Differentiated Vulvar Intraepithelial Neoplasia (dVIN) is Associated With an Aggressive Clinical Course. 61
28319571 2017
47
Papillomavirus genotyping on formaldehyde fixed paraffin-embedded tissues in vulvar intraepithelial neoplasia. 61
28795241 2017
48
Decreased NK cell activity after partial vulvectomy in pregnant patient with vulvar intraepithelial neoplasia 3 (VIN3). 61
28954490 2017
49
HPV16 E7 DNA tattooing: safety, immunogenicity, and clinical response in patients with HPV-positive vulvar intraepithelial neoplasia. 61
28451790 2017
50
Vulvar Neoplasms, Benign and Malignant. 61
28778635 2017

Variations for Vulvar Intraepithelial Neoplasia

Expression for Vulvar Intraepithelial Neoplasia

Search GEO for disease gene expression data for Vulvar Intraepithelial Neoplasia.

Pathways for Vulvar Intraepithelial Neoplasia

Pathways related to Vulvar Intraepithelial Neoplasia according to GeneCards Suite gene sharing:

(show all 38)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.49 TP53 H2AX CTNNB1 CDKN2A BIRC5
2
Show member pathways
12.7 H2AX CTNNB1 CDH1 BIRC5
3
Show member pathways
12.48 TP53 CTNNB1 CDH1
4
Show member pathways
12.44 TP53 CDKN2A CDH1
5
Show member pathways
12.37 TP53 CTNNB1 CDKN2A CDH1
6
Show member pathways
12.36 TP53 CDKN2A BIRC5
7
Show member pathways
12.36 TP53 CTNNB1 BIRC5
8
Show member pathways
12.3 TP53 CTNNB1 CDKN2A CDH1 BIRC5
9 12.27 TP53 H2AX CDKN2A
10
Show member pathways
12.27 TP53 CTNNB1 CDH1
11
Show member pathways
12.13 TP53 H2AX CDKN2A
12 12.1 TP53 CDKN2A CDH1
13 11.96 TP53 CTNNB1 CDH1 BIRC5
14 11.87 TP53 CTNNB1 CDH1
15 11.86 CTNNB1 CDH1 BIRC5
16 11.75 TP53 CTNNB1 CDKN2A CDH1 BIRC5
17 11.69 TP53 CTNNB1 CDKN2A
18 11.65 TP53 CTNNB1 CDKN2A
19 11.47 TP53 CTNNB1 CDH1 BIRC5
20 11.43 TP53 CTNNB1 CDKN2A
21 11.41 TP53 CDKN2A BIRC5
22 11.4 TP53 CDKN2A
23 11.37 TP53 CDKN2A
24 11.37 TP53 BIRC5
25 11.36 TP53 CDKN2A CDH1
26 11.35 TP53 H2AX
27 11.29 CTNNB1 CDH1
28 11.24 CTNNB1 CDH1
29 11.23 CTNNB1 CDH1
30 11.2 TP53 BIRC5
31 11.14 TP53 CTNNB1
32 11.13 CTNNB1 CDH1
33 11.11 TP53 CDKN2A
34 11.09 TP53 BIRC5
35 10.97 CTNNB1 CDH1
36
Show member pathways
10.9 TP53 CDKN2A
37 10.89 TP53 CDKN2A
38 10.59 CTNNB1 CDH1

GO Terms for Vulvar Intraepithelial Neoplasia

Cellular components related to Vulvar Intraepithelial Neoplasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 site of double-strand break GO:0035861 9.37 TP53 H2AX
2 lateral plasma membrane GO:0016328 9.32 CTNNB1 CDH1
3 catenin complex GO:0016342 9.26 CTNNB1 CDH1
4 replication fork GO:0005657 9.16 TP53 H2AX
5 apical junction complex GO:0043296 8.96 CTNNB1 CDH1
6 flotillin complex GO:0016600 8.62 CTNNB1 CDH1

Biological processes related to Vulvar Intraepithelial Neoplasia according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.7 TP53 CTNNB1 CDKN2A
2 response to drug GO:0042493 9.67 TP53 CTNNB1 CDH1
3 cell cycle GO:0007049 9.67 TP53 H2AX CDKN2A BIRC5
4 regulation of apoptotic process GO:0042981 9.65 TP53 CTNNB1 BIRC5
5 positive regulation of transcription, DNA-templated GO:0045893 9.62 TP53 CTNNB1 CDKN2A CDH1
6 positive regulation of neuron apoptotic process GO:0043525 9.54 TP53 CTNNB1
7 adherens junction organization GO:0034332 9.51 CTNNB1 CDH1
8 cellular response to gamma radiation GO:0071480 9.46 TP53 H2AX
9 negative regulation of transcription, DNA-templated GO:0045892 9.46 TP53 CTNNB1 CDKN2A BIRC5
10 T cell differentiation in thymus GO:0033077 9.43 TP53 CTNNB1
11 cellular senescence GO:0090398 9.4 H2AX CDKN2A
12 replicative senescence GO:0090399 9.26 TP53 CDKN2A
13 entry of bacterium into host cell GO:0035635 8.96 CTNNB1 CDH1
14 cellular response to indole-3-methanol GO:0071681 8.62 CTNNB1 CDH1

Molecular functions related to Vulvar Intraepithelial Neoplasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor binding GO:0008134 9.33 TP53 CTNNB1 CDKN2A
2 RNA polymerase II transcription factor binding GO:0001085 9.32 TP53 CTNNB1
3 RNA polymerase II activating transcription factor binding GO:0001102 9.26 TP53 CTNNB1
4 enzyme binding GO:0019899 9.26 TP53 H2AX CTNNB1 BIRC5
5 disordered domain specific binding GO:0097718 8.8 TP53 CTNNB1 CDKN2A

Sources for Vulvar Intraepithelial Neoplasia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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