MCID: VLV044
MIFTS: 43

Vulvar Intraepithelial Neoplasia

Categories: Rare diseases, Reproductive diseases

Aliases & Classifications for Vulvar Intraepithelial Neoplasia

MalaCards integrated aliases for Vulvar Intraepithelial Neoplasia:

Name: Vulvar Intraepithelial Neoplasia 59
Vulval Intraepithelial Neoplasia 73
Vulvar Intraepithelial Tumor 59

Classifications:



External Ids:

Orphanet 59 ORPHA137583
ICD10 via Orphanet 34 D07.1
UMLS via Orphanet 74 C0346210
UMLS 73 C0346210

Summaries for Vulvar Intraepithelial Neoplasia

MalaCards based summary : Vulvar Intraepithelial Neoplasia, also known as vulval intraepithelial neoplasia, is related to vulva cancer and papilloma, and has symptoms including pruritus and macule. An important gene associated with Vulvar Intraepithelial Neoplasia is TP53 (Tumor Protein P53), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Pathways in cancer. The drugs Imiquimod and Aluminum hydroxide have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and lung, and related phenotype is immune system.

Wikipedia : 76 Vulvar intraepithelial neoplasia (VIN) refers to particular changes that can occur in the skin that... more...

Related Diseases for Vulvar Intraepithelial Neoplasia

Diseases related to Vulvar Intraepithelial Neoplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 89)
# Related Disease Score Top Affiliating Genes
1 vulva cancer 32.5 KRT7 TP53
2 papilloma 30.4 KRT7 TP53
3 vulvar disease 30.2 KRT7 TP53
4 squamous cell carcinoma 10.7
5 lichen sclerosus 10.5
6 viral infectious disease 10.3
7 anogenital venereal wart 10.2
8 vaginal cancer 10.2
9 in situ carcinoma 10.2
10 cervical intraepithelial neoplasia 10.2
11 bladder transitional cell papilloma 10.1 BIRC5 TP53
12 cervical carcinosarcoma 10.1 BIRC5 TP53
13 keratocystic odontogenic tumor 10.1 BIRC5 TP53
14 recessive dystrophic epidermolysis bullosa 10.1 MMP1 TP53
15 malignant spiradenoma 10.1 KRT7 TP53
16 spiradenoma 10.1 KRT7 TP53
17 bladder carcinoma in situ 10.1 KRT7 TP53
18 papillary serous adenocarcinoma 10.1 KRT7 TP53
19 nasal cavity adenocarcinoma 10.1 KRT7 TP53
20 female reproductive endometrioid cancer 10.1 KRT7 TP53
21 carcinosarcoma 10.1 KRT7 TP53
22 glycogen-rich clear cell breast carcinoma 10.1 KRT7 TP53
23 prostate squamous cell carcinoma 10.1 KRT7 TP53
24 pleomorphic carcinoma 10.1 KRT7 TP53
25 biliary papillomatosis 10.1 KRT7 TP53
26 endocervical adenocarcinoma 10.1 KRT7 TP53
27 cervical adenocarcinoma 10.1 KRT7 TP53
28 eccrine sweat gland neoplasm 10.1 KRT7 TP53
29 appendix cancer 10.1 KRT7 TP53
30 epithelial-myoepithelial carcinoma 10.1 KRT7 TP53
31 necrotizing sialometaplasia 10.1 KRT7 TP53
32 cystic teratoma 10.1 KRT7 TP53
33 teratoma 10.1 KRT7 TP53
34 basaloid squamous cell carcinoma 10.1 KRT7 TP53
35 biliary tract neoplasm 10.1 KRT7 TP53
36 mixed cell type cancer 10.1 KRT7 TP53
37 granulosa cell tumor of the ovary 10.1 KRT7 TP53
38 hidradenocarcinoma 10.1 KRT7 TP53
39 acinar cell carcinoma 10.1 KRT7 TP53
40 pseudomyxoma peritonei 10.1 KRT7 TP53
41 tonsil cancer 10.1 KRT7 TP53
42 neurofibromatosis, type ii 10.1
43 systemic lupus erythematosus 10.1
44 retinal dystrophy, iris coloboma, and comedogenic acne syndrome 10.1
45 chlamydia 10.1
46 melanoma 10.1
47 vulva squamous cell carcinoma 10.1
48 herpes simplex 10.1
49 lupus erythematosus 10.1
50 amyloidosis 10.1

Graphical network of the top 20 diseases related to Vulvar Intraepithelial Neoplasia:



Diseases related to Vulvar Intraepithelial Neoplasia

Symptoms & Phenotypes for Vulvar Intraepithelial Neoplasia

UMLS symptoms related to Vulvar Intraepithelial Neoplasia:


pruritus, macule

MGI Mouse Phenotypes related to Vulvar Intraepithelial Neoplasia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.02 BIRC5 HAVCR2 KLRC1 MMP1 TP53

Drugs & Therapeutics for Vulvar Intraepithelial Neoplasia

Drugs for Vulvar Intraepithelial Neoplasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Imiquimod Approved, Investigational Phase 2, Phase 3,Phase 3 99011-02-6 57469
2
Aluminum hydroxide Approved, Investigational Phase 3 21645-51-2
3
Aluminum sulfate Approved Phase 3 10043-01-3
4 Immunologic Factors Phase 3,Phase 2,Phase 1
5 Vaccines Phase 3,Phase 2,Phase 1
6 Adjuvants, Immunologic Phase 2, Phase 3,Phase 3
7 Interferon Inducers Phase 2, Phase 3,Phase 3
8 interferons Phase 2, Phase 3,Phase 3
9 Anesthetics Phase 3
10
Omeprazole Approved, Investigational, Vet_approved Phase 2 73590-58-6 4594
11
Cyclophosphamide Approved, Investigational Phase 2,Phase 1 6055-19-2, 50-18-0 2907
12
Zinc Approved, Investigational Phase 2 7440-66-6
13
Indomethacin Approved, Investigational Phase 2 53-86-1 3715
14
Fludarabine Approved Phase 1, Phase 2,Phase 2 75607-67-9, 21679-14-1 30751
15
Aldesleukin Approved Phase 1, Phase 2 85898-30-2, 110942-02-4
16 Anti-Inflammatory Agents, Non-Steroidal Phase 2
17 Antacids Phase 2
18 Antineoplastic Agents, Alkylating Phase 2,Phase 1
19 Cyclooxygenase Inhibitors Phase 2
20 Alkylating Agents Phase 2,Phase 1
21 Anti-Inflammatory Agents Phase 2
22 Analgesics Phase 2,Phase 1
23 Proton Pump Inhibitors Phase 2
24 Anti-Ulcer Agents Phase 2
25 Analgesics, Non-Narcotic Phase 2,Phase 1
26 Immunosuppressive Agents Phase 2,Phase 1
27 Antirheumatic Agents Phase 2,Phase 1
28 Peripheral Nervous System Agents Phase 2,Phase 1
29 Tocolytic Agents Phase 2
30 Gastrointestinal Agents Phase 2
31 Vitamins Phase 2
32 Antiviral Agents Phase 1, Phase 2
33 Anti-HIV Agents Phase 1, Phase 2
34 Anti-Retroviral Agents Phase 1, Phase 2
35 Anti-Infective Agents Phase 1, Phase 2
36 Interleukin-2 Phase 1, Phase 2

Interventional clinical trials:

(show all 31)
# Name Status NCT ID Phase Drugs
1 Cervical Intraepithelial Neoplasm (CIN)-Warts Efficacy Trial in Women (Gardasil)(V501-013)(COMPLETED) Completed NCT00092521 Phase 3
2 A Randomized Trial of Surgical Treatments for Vulvar and Vaginal Dysplasia Completed NCT00394758 Phase 3
3 ITIC (Imiquimod Therapy in Cervical Intraepithelial Neoplasia)-Trial Completed NCT00941252 Phase 2, Phase 3 Topical imiquimod therapy
4 A Bridging Study of a Recombinant Human Papillomavirus 16/18 Bivalent Vaccine in Preadolescent Girls Completed NCT02562508 Phase 3
5 Broad Spectrum HPV (Human Papillomavirus) Vaccine Study in 16-to 26-Year-Old Women (V503-001) Completed NCT00543543 Phase 3
6 A Study to Evaluate the Safety, Immune Response, and Efficacy of Gardasil (V501, qHPV) in Mid-Adult Women (V501-019) Completed NCT00090220 Phase 3
7 A Study of Gardasil (V501) in Preadolescents and Adolescents (V501-018) Completed NCT00092547 Phase 3
8 Primary Imiquimod Treatment Versus Surgery for Vulvar Intraepithelial Neoplasia Recruiting NCT01861535 Phase 3 Imiquimod
9 Efficacy and Immunogenicity Study of Recombinant Human Papillomavirus Bivalent(Type 16/18 )Vaccine Active, not recruiting NCT01735006 Phase 3
10 Imiquimod Treatment of CIN Lesions Terminated NCT02329171 Phase 3 Imiquimod
11 Immunevasion of Human Papillomavirus (HPV) in Vulvar Intraepithelial Neoplasia 2/3 and Anogenital Warts and Efficiency and Mechanisms of Imiquimod Treatment Completed NCT00941811 Phase 2 Imiquimod
12 Pharmacodynamics, Safety/Tolerability and Efficacy of Topical Omiganan in Patients With uVIN Completed NCT02596074 Phase 2 Omiganan (CLS001) topical gel;Vehicle topical gel
13 The Impact of the "WOMAN-PRO II Program" on Patients With Vulvar Neoplasia to Minimize Post-surgical Symptom Prevalence Completed NCT01986725 Phase 2
14 Dose-Ranging Study of Quadrivalent Human Papillomavirus (HPV) (Types 6,11,16,18) L1 Virus-Like Particle (VLP) Vaccine (V501-007)(COMPLETED) Completed NCT00365716 Phase 2
15 V501 Efficacy Study in Women Aged 18 to 26 (V501-027) Completed NCT00378560 Phase 2
16 IRX-2 Regimen in Treating Women With Cervical Squamous Intraepithelial Neoplasia 3 or Squamous Vulvar Intraepithelial Neoplasia 3 Recruiting NCT03267680 Phase 2 Cyclophosphamide;Indomethacin;Omeprazole
17 Evaluation of VGX-3100 and Electroporation Alone or in Combination With Imiquimod for the Treatment of HPV-16 and/or HPV-18 Related Vulvar HSIL (Also Referred as: VIN 2 or VIN 3) Recruiting NCT03180684 Phase 2 Imiquimod 5% cream
18 E7 TCR T Cells for Human Papillomavirus-Associated Cancers Recruiting NCT02858310 Phase 1, Phase 2 Aldesleukin;Fludarabine;Cyclophosphamide
19 Artesunate Ointment for the Treatment of High Grade Vulvar Intraepithelial Neoplasia (HSIL VIN2/3) Not yet recruiting NCT03792516 Phase 1 artesunate ointment 40%
20 Evaluate the Safety and Primary Immunogenicity of 9-valent HPV Recombinant Vaccine in Chinese Healthy Females Not yet recruiting NCT03676101 Phase 1
21 Interest of the Confocal Microscope in the Diagnosis of Epidermoid Carcinoma of the Vulva and Their Precursors Unknown status NCT02735109 Not Applicable
22 A New Patient Reported Outcome Instrument to Assess Symptom Experience in Women With Vulvar Neoplasms (WOMAN-PRO) Unknown status NCT01300663
23 SR-T100 Gel Efficacy & Safety Study for Vulva Pre-cancerous Lesions & Cutaneous Condyloma Completed NCT01676792 Early Phase 1 SR-T100 gel with 2.3% of SM in Solanum undatum plant extract
24 Immuno-persistence Study of a Recombinant Human Papillomavirus 16/18 Bivalent Vaccine in Preadolescent Girls Completed NCT03206255
25 Ultrasonic Aspiration Versus CO2 Laser Ablation for the Treatment of Vulvar Intraepithelial Neoplasia Recruiting NCT02875561 Not Applicable
26 Biospecimen Collection and Testing for the Prevalence of Anal Dysplasia and Anal Cancer in Patients With Cervical, Vaginal and Vulvar Dysplasia and Cancer Recruiting NCT02140021 Not Applicable
27 Evaluation of Long-term HPV Vaccine Efficacy Enrolling by invitation NCT01393470
28 Screening for Anal Cancer in Women With High-grade Vulvar Dysplasia or Vulvar Cancer. Not yet recruiting NCT03061435 Not Applicable
29 OCT-AF Imaging of Pre-cancers of Vulva and Cervix Not yet recruiting NCT03285841
30 Evaluation of the Role of Vibrational Spectroscopy in the Assessment of Vulval Disease Suspended NCT02223975
31 Colposcopy and High Resolution Anoscopy in Screening For Anal Dysplasia in Patients With Cervical, Vaginal, or Vulvar Dysplasia or Cancer Withdrawn NCT01313104 Not Applicable

Search NIH Clinical Center for Vulvar Intraepithelial Neoplasia

Genetic Tests for Vulvar Intraepithelial Neoplasia

Anatomical Context for Vulvar Intraepithelial Neoplasia

MalaCards organs/tissues related to Vulvar Intraepithelial Neoplasia:

41
Skin, T Cells, Lung, Brain, Bone, Ovary, Thymus

Publications for Vulvar Intraepithelial Neoplasia

Articles related to Vulvar Intraepithelial Neoplasia:

(show top 50) (show all 313)
# Title Authors Year
1
Vulvar intraepithelial neoplasia: Risk factors for recurrence. ( 29126556 )
2018
2
Differential expression patterns of GATA3 in usual and differentiated types of vulvar intraepithelial neoplasia: potential diagnostic implications. ( 29434343 )
2018
3
Vulvar intraepithelial neoplasia and vulvar squamous cell carcinoma: differential dermoscopic features in a case series, and a progression model. ( 29315730 )
2018
4
Differentiated Vulvar Intraepithelial Neoplasia-like and Lichen Sclerosus-like Lesions in HPV-associated Squamous Cell Carcinomas of the Vulva. ( 29505429 )
2018
5
Classic Vulvar Intraepithelial Neoplasia With Superimposed Lichen Simplex Chronicus: A Unique Variant Mimicking Differentiated Vulvar Intraepithelial Neoplasia. ( 29750709 )
2018
6
The Role of Photodynamic Therapy in the Treatment of Vulvar Intraepithelial Neoplasia. ( 29393881 )
2018
7
Impact of re-excision of residual adjacent vulvar intraepithelial neoplasia (VIN III) and histological tumour-free margin (hTFM) on survival in primary squamous cell carcinoma of vulva. ( 30187190 )
2018
8
Human Papillomavirus Genotypes From Vaginal and Vulvar Intraepithelial Neoplasia in Females 15-26 Years of Age. ( 29995724 )
2018
9
Differentiated vulvar intraepithelial neoplasia (dVIN): the most helpful histological features and the utility of cytokeratins 13 and 17. ( 30187167 )
2018
10
Vulvar intraepithelial neoplasia treated with a combination of surgical excision and laser ablation during pregnancy. ( 30214782 )
2018
11
Recurrence of vulval intraepithelial neoplasia following treatment with cidofovir or imiquimod: results from a multicentre, randomised, phase II trial (RT3VIN). ( 29336101 )
2018
12
Is cidofovir a better treatment than imiquimod for high-grade vulval intraepithelial neoplasia? ( 29453897 )
2018
13
Yield of Cytology Surveillance After High-Grade Vulvar Intraepithelial Neoplasia or Cancer. ( 28644191 )
2017
14
HPV-independent Differentiated Vulvar Intraepithelial Neoplasia (dVIN) is Associated With an Aggressive Clinical Course. ( 28319571 )
2017
15
Dermoscopic features of pigmented vulvar intraepithelial neoplasia. ( 28940726 )
2017
16
Committee Opinion No. 675: Management of Vulvar Intraepithelial Neoplasia: Correction. ( 28092302 )
2017
17
Papillomavirus genotyping on formaldehyde fixed paraffin-embedded tissues in vulvar intraepithelial neoplasia. ( 28795241 )
2017
18
Decreased NK cell activity after partial vulvectomy in pregnant patient with vulvar intraepithelial neoplasia 3 (VIN3). ( 28954490 )
2017
19
HPV16 E7 DNA tattooing: safety, immunogenicity, and clinical response in patients with HPV-positive vulvar intraepithelial neoplasia. ( 28451790 )
2017
20
Imiquimod cream and C02 laser vaporization in vulvar intraepithelial neoplasia (VIN) 2/3 treatment. ( 29693875 )
2017
21
Human Papillomavirus DNA Methylation Predicts Response to Treatment Using Cidofovir and Imiquimod in Vulval Intraepithelial Neoplasia 3. ( 28600473 )
2017
22
Committee Opinion No.675: Management of Vulvar Intraepithelial Neoplasia. ( 27661656 )
2016
23
Differentiated Vulvar Intraepithelial Neoplasia: What Criteria Do We Use in Practice? ( 27105329 )
2016
24
Committee Opinion No. 675 Summary: Management of Vulvar Intraepithelial Neoplasia. ( 27661648 )
2016
25
Usual-type vulvar intraepithelial neoplasia: report of a case and its dermoscopic features. ( 27419656 )
2016
26
MALDI Mass Spectrometry Imaging Reveals Decreased CK5 Levels in Vulvar Squamous Cell Carcinomas Compared to the Precursor Lesion Differentiated Vulvar Intraepithelial Neoplasia. ( 27399691 )
2016
27
Distinguishing Erosive Lichen Planus From Differentiated Vulvar Intraepithelial Neoplasia. ( 26796658 )
2016
28
Dermoscopic findings of vulvar intraepithelial neoplasia (VIN): a series of 4 cases. ( 27291788 )
2016
29
Assessment of CK17 as a Marker for the Diagnosis of Differentiated Vulvar Intraepithelial Neoplasia. ( 27513074 )
2016
30
Type-specific HPV infection correlates with risk of recurrence of vulvar intraepithelial neoplasia usual type. ( 28006842 )
2016
31
Vulvar intraepithelial neoplasia grade 3 associated with BehAset's disease. ( 26983442 )
2016
32
The Natural History of Vulvar Intraepithelial Neoplasia, Differentiated Type: Evidence for Progression and Diagnostic Challenges. ( 26974999 )
2016
33
Extra-Genital Bowen's Disease on Abdomen Co-existing with Vulvar Intraepithelial Neoplasia. ( 27298533 )
2016
34
Vulvar intraepithelial neoplasia: clinical presentation, management and outcomes in women infected with HIV. ( 26959352 )
2016
35
Medical and Surgical Treatments for Usual-Type Vulvar Intraepithelial Neoplasia. ( 27490514 )
2016
36
Vulvar and Vaginal Cancer, Vulvar Intraepithelial Neoplasia 3 and Vaginal Intraepithelial Neoplasia 3: Experience of a Referral Institute. ( 27430086 )
2016
37
Usual vulval intraepithelial neoplasia in HIV-positive women - a case series. ( 26472432 )
2016
38
Medical and surgical interventions for the treatment of usual-type vulval intraepithelial neoplasia. ( 26728940 )
2016
39
A case series of young women with spontaneous regression of vulval intraepithelial neoplasia: Demographics and associated HPV genotypes. ( 26940977 )
2016
40
Vulvar Intraepithelial Neoplasia (VIN) and Condylomata. ( 26133495 )
2015
41
Imiquimod in cervical, vaginal and vulvar intraepithelial neoplasia: A review. ( 26335596 )
2015
42
Efficacy of 5% imiquimod cream on vulvar intraepithelial neoplasia in Korea: pilot study. ( 25673934 )
2015
43
LASER VAPORIZATION IN VULVAR INTRAEPITHELIAL NEOPLASIA (VIN), VAGINAL INTRAEPITHELIAL NEOPLASIA (VAIN) AND CONDYLOMATA ACUMINATA: IGCS-0093 Vulvar and Vaginal Cancer. ( 25955950 )
2015
44
No viral association found in a set of differentiated vulvar intraepithelial neoplasia cases by human papillomavirus and pan-viral microarray testing. ( 25894343 )
2015
45
Medical interventions for high-grade vulval intraepithelial neoplasia. ( 26284429 )
2015
46
Vulvar intraepithelial neoplasia. ( 25106700 )
2014
47
Expression of coinhibitory receptors on T cells in the microenvironment of usual vulvar intraepithelial neoplasia is related to proinflammatory effector T cells and an increased recurrence-free survival. ( 25220367 )
2014
48
An update on vulvar intraepithelial neoplasia: terminology and a practical approach to diagnosis. ( 24399036 )
2014
49
Surgical treatment of usual type vulvar intraepithelial neoplasia: a study at three academic hospitals. ( 24534242 )
2014
50
Localized amyloidosis of the vulva with and without vulvar intraepithelial neoplasia: report of a series. ( 25149547 )
2014

Variations for Vulvar Intraepithelial Neoplasia

Expression for Vulvar Intraepithelial Neoplasia

Search GEO for disease gene expression data for Vulvar Intraepithelial Neoplasia.

Pathways for Vulvar Intraepithelial Neoplasia

Pathways related to Vulvar Intraepithelial Neoplasia according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.81 BIRC5 HAVCR2 MMP1 TP53
2 12.42 BIRC5 MMP1 TP53
3
Show member pathways
11.56 BIRC5 TP53
4 11.55 BIRC5 MMP1 TP53
5 11.42 MMP1 TP53
6 11.4 BIRC5 TP53
7 11.34 MMP1 TP53
8 11.32 BIRC5 TP53
9
Show member pathways
11.23 BIRC5 MMP1
10 11.19 BIRC5 MMP1 TP53
11 11.03 MMP1 TP53
12 10.89 BIRC5 TP53
13 10.75 BIRC5 TP53
14 10.51 BIRC5 MMP1 TP53

GO Terms for Vulvar Intraepithelial Neoplasia

Biological processes related to Vulvar Intraepithelial Neoplasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.33 KRT7 MMP1 TP53
2 cytokine-mediated signaling pathway GO:0019221 9.13 BIRC5 MMP1 TP53
3 positive regulation of protein oligomerization GO:0032461 8.62 MMP1 TP53

Molecular functions related to Vulvar Intraepithelial Neoplasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chaperone binding GO:0051087 8.62 BIRC5 TP53

Sources for Vulvar Intraepithelial Neoplasia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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