VIN
MCID: VLV044
MIFTS: 44

Vulvar Intraepithelial Neoplasia (VIN)

Categories: Rare diseases, Reproductive diseases

Aliases & Classifications for Vulvar Intraepithelial Neoplasia

MalaCards integrated aliases for Vulvar Intraepithelial Neoplasia:

Name: Vulvar Intraepithelial Neoplasia 59 17
Vulval Intraepithelial Neoplasia 72
Vulvar Intraepithelial Tumor 59
Vin 59

Classifications:



External Ids:

ICD10 via Orphanet 34 D07.1
UMLS via Orphanet 73 C0346210
Orphanet 59 ORPHA137583
UMLS 72 C0346210

Summaries for Vulvar Intraepithelial Neoplasia

MalaCards based summary : Vulvar Intraepithelial Neoplasia, also known as vulval intraepithelial neoplasia, is related to vulva cancer and vulva squamous cell carcinoma, and has symptoms including pruritus and macule. An important gene associated with Vulvar Intraepithelial Neoplasia is TP53 (Tumor Protein P53), and among its related pathways/superpathways are Human cytomegalovirus infection and Development HGF signaling pathway. The drugs Imiquimod and Aminolevulinic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and testes, and related phenotypes are cellular and embryo

Wikipedia : 75 Vulvar intraepithelial neoplasia (VIN) refers to particular changes that can occur in the skin that... more...

Related Diseases for Vulvar Intraepithelial Neoplasia

Diseases related to Vulvar Intraepithelial Neoplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 196)
# Related Disease Score Top Affiliating Genes
1 vulva cancer 33.2 TP53 CDKN2A
2 vulva squamous cell carcinoma 31.5 TP53 CDKN2A
3 cervix uteri carcinoma in situ 31.4 TP53 CDKN2A
4 squamous cell papilloma 31.4 TP53 CDKN2A
5 vulvar disease 31.2 TP53 CDKN2A
6 cervical intraepithelial neoplasia 31.2 CDKN2A BIRC5
7 anogenital venereal wart 31.0 TP53 CDKN2A
8 keratinizing squamous cell carcinoma 30.8 TP53 CDKN2A
9 suppressor of tumorigenicity 3 30.8 TP53 CDKN2A
10 in situ carcinoma 30.6 TP53 CDKN2A CDH1
11 verrucous carcinoma 30.4 TP53 CDKN2A
12 leukemia, acute lymphoblastic 3 29.9 TP53 CDKN2A
13 squamous cell carcinoma 29.6 TP53 CTNNB1 CDKN2A CDH1
14 cervical cancer 28.0 TP53 CTNNB1 CDKN2A CDH1 BIRC5
15 lichen sclerosus 10.9
16 papilloma 10.7
17 bladder transitional cell papilloma 10.4 TP53 BIRC5
18 cervical carcinosarcoma 10.4 TP53 BIRC5
19 male reproductive system disease 10.4 TP53 CDH1
20 keratosis 10.4
21 cerebral convexity meningioma 10.3 TP53 CDH1
22 neutropenia 10.3
23 keratocystic odontogenic tumor 10.3 TP53 BIRC5
24 sarcomatoid renal cell carcinoma 10.3 TP53 CDH1
25 immune deficiency disease 10.3
26 bowenoid papulosis 10.3
27 papillary adenocarcinoma 10.3 TP53 CDH1
28 bile duct adenocarcinoma 10.3 TP53 CDH1
29 bladder squamous cell carcinoma 10.2 TP53 CDKN2A
30 spitz nevus 10.2 TP53 CDKN2A
31 bladder carcinoma in situ 10.2 TP53 CDKN2A
32 scrotal carcinoma 10.2 TP53 CDKN2A
33 bartholin's gland disease 10.2 TP53 CDKN2A
34 nasal cavity adenocarcinoma 10.2 TP53 CDKN2A
35 thyroid lymphoma 10.2 TP53 CDKN2A
36 anal squamous cell carcinoma 10.2 TP53 CDKN2A
37 gastric adenosquamous carcinoma 10.2 TP53 CDKN2A
38 glycogen-rich clear cell breast carcinoma 10.2 TP53 CDKN2A
39 megaesophagus 10.2 TP53 CDKN2A
40 vaginal cancer 10.2
41 mammary paget's disease 10.2
42 lichen planus 10.2
43 48,xyyy 10.2
44 oral leukoplakia 10.2 TP53 CDKN2A
45 uterus carcinoma in situ 10.2 TP53 CDKN2A
46 meningeal melanomatosis 10.2 TP53 CDKN2A
47 dedifferentiated liposarcoma 10.2 TP53 CDKN2A
48 liposarcoma 10.2 TP53 CDKN2A
49 endocervical adenocarcinoma 10.2 TP53 CDKN2A
50 cervical adenocarcinoma 10.2 TP53 CDKN2A

Graphical network of the top 20 diseases related to Vulvar Intraepithelial Neoplasia:



Diseases related to Vulvar Intraepithelial Neoplasia

Symptoms & Phenotypes for Vulvar Intraepithelial Neoplasia

UMLS symptoms related to Vulvar Intraepithelial Neoplasia:


pruritus, macule

MGI Mouse Phenotypes related to Vulvar Intraepithelial Neoplasia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.88 BIRC5 CDH1 CDKN2A CTNNB1 HAVCR2 TP53
2 embryo MP:0005380 9.77 BIRC5 CDH1 CDKN2A CTNNB1 TP53
3 immune system MP:0005387 9.73 BIRC5 CDH1 CDKN2A CTNNB1 HAVCR2 TP53
4 endocrine/exocrine gland MP:0005379 9.72 BIRC5 CDH1 CDKN2A CTNNB1 TP53
5 mortality/aging MP:0010768 9.63 BIRC5 CDH1 CDKN2A CTNNB1 HAVCR2 TP53
6 neoplasm MP:0002006 9.26 CDH1 CDKN2A CTNNB1 TP53
7 no phenotypic analysis MP:0003012 8.92 CDH1 CDKN2A CTNNB1 TP53

Drugs & Therapeutics for Vulvar Intraepithelial Neoplasia

Drugs for Vulvar Intraepithelial Neoplasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 56)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Imiquimod Approved, Investigational Phase 4 99011-02-6 57469
2
Aminolevulinic acid Approved Phase 4 106-60-5 137
3 Adjuvants, Immunologic Phase 4
4 Immunologic Factors Phase 4
5 interferons Phase 4
6 Interferon Inducers Phase 4
7 Pharmaceutical Solutions Phase 4
8 Dermatologic Agents Phase 4
9 Photosensitizing Agents Phase 4
10
Aluminum hydroxide Approved, Investigational Phase 3 21645-51-2
11
Aluminum sulfate Approved Phase 3 10043-01-3
12 Anesthetics Phase 3
13
Omeprazole Approved, Investigational, Vet_approved Phase 2 73590-58-6 4594
14
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
15
Indomethacin Approved, Investigational Phase 2 53-86-1 3715
16
Zinc Approved, Investigational Phase 2 7440-66-6 32051
17
Fludarabine Approved Phase 1, Phase 2 21679-14-1, 75607-67-9 30751
18
Aldesleukin Approved Phase 1, Phase 2 85898-30-2, 110942-02-4
19
Digoxin Approved Phase 2 20830-75-5 30322 2724385
20
Furosemide Approved, Vet_approved Phase 2 54-31-9 3440
21 Anti-Bacterial Agents Phase 2
22 Antimicrobial Cationic Peptides Phase 2
23 Interferon-alpha Phase 1, Phase 2
24 Anti-Infective Agents Phase 1, Phase 2
25 Antiviral Agents Phase 1, Phase 2
26 Analgesics Phase 2
27 Alkylating Agents Phase 2
28 Gastrointestinal Agents Phase 2
29 Cyclooxygenase Inhibitors Phase 2
30 Analgesics, Non-Narcotic Phase 2
31 Antacids Phase 2
32 Tocolytic Agents Phase 2
33 Anti-Inflammatory Agents, Non-Steroidal Phase 2
34 Vitamins Phase 2
35 Peripheral Nervous System Agents Phase 2
36 Immunosuppressive Agents Phase 2
37 Anti-Inflammatory Agents Phase 2
38 Proton Pump Inhibitors Phase 2
39 Anti-Ulcer Agents Phase 2
40 Antirheumatic Agents Phase 2
41 Antineoplastic Agents, Alkylating Phase 2
42 Vaccines Phase 1, Phase 2
43 Anti-HIV Agents Phase 1, Phase 2
44 Anti-Retroviral Agents Phase 1, Phase 2
45 Interleukin-2 Phase 1, Phase 2
46 Cardiotonic Agents Phase 2
47 diuretics Phase 2
48 Natriuretic Agents Phase 2
49 Sodium Potassium Chloride Symporter Inhibitors Phase 2
50 Protective Agents Phase 2

Interventional clinical trials:

(show all 23)
# Name Status NCT ID Phase Drugs
1 An Exploratory, Open-label Study of Sequential Field-directed Treatment of Actinic Keratoses of the Face With Imiquimod 3.75% Cream Followed by Photodynamic Therapy Terminated NCT01203878 Phase 4 Photodynamic therapy;Imiquimod
2 A Study to Evaluate the Efficacy of Quadrivalent HPV Vaccine in Reducing the Incidence of HPV 6-, 11-, 16-, and 18-Related CIN, AIS, and Cervical Cancer, and HPV 6-, 11-, 16-, and 18-Related External Genital Warts, Vulvar Intraepithelial Neoplasia Vaginal Intraepithelial Neoplasia, Vulvar Cancer, and Vaginal Cancer in 16- to 23-Year-Old Women Completed NCT00092521 Phase 3
3 Comparison of Surgical Procedures in Vulvar and Vaginal Dysplasias Completed NCT00394758 Phase 3
4 Topical Imiquimod in Treating Patients With Grade 2/3 Cervical Intraepithelial Neoplasia Completed NCT00941252 Phase 2, Phase 3 Topical imiquimod therapy
5 Primary Imiquimod Treatment Versus Surgery for Vulvar Intraepithelial Neoplasia Recruiting NCT01861535 Phase 3 Imiquimod
6 A Phase III Multicenter, Randomized, Double-Blind, Placebo(Hepatitis E Vaccine)Controlled Study to Evaluate the Efficacy, Immunogenicity and Safety of a Recombinant(E.Coli)Human Papillomavirus Bivalent Vaccine in Healthy Women Active, not recruiting NCT01735006 Phase 3
7 ITIC2 Trial - Topical Imiquimod Versus Conization to Treat Cervical Intraepithelial Neoplasia: Randomised Controlled, Non-inferiority Trial Terminated NCT01283763 Phase 3 Topical Imiquimod
8 TOPical Imiquimod Treatment of High-grade Cervical Intraepithelial Neoplasm: a Randomized Controlled Trial. Terminated NCT02329171 Phase 3 Imiquimod
9 A Phase 2, Randomized, Double-Blind, Parallel-Group Study to Assess the Pharmacodynamics, Safety/Tolerability and Efficacy of Topical Omiganan in Patients With Usual Type Vulvar Intraepithelial Neoplasia Completed NCT02596074 Phase 2 Omiganan (CLS001) topical gel;Vehicle topical gel
10 An Explorative, Single Center and Controlled Study to Analyze the Immune Escape Mechanisms of HPV-associated Lesions and to Evaluate the Efficiency and Mechanisms of Imiquimod Treatment of Vulvar Intraepithelial Neoplasias 2/3 (VIN) and Anogenital Warts Completed NCT00941811 Phase 2 Imiquimod
11 The Impact of the Self-management Intervention "WOMAN-PRO II Program" on Patients With Vulvar Neoplasia to Minimize Post-surgical Symptom Prevalence: A Mixed-Methods Project Completed NCT01986725 Phase 2
12 Therapeutic Vaccination Against Human Papillomavirus Type 16 for the Treatment of Anal Intraepithelial Neoplasia in HIV+ Men Completed NCT01923116 Phase 1, Phase 2 HPV-16 vaccine
13 A Two-Cohort Randomized Phase 2 Trial of the IRX-2 Regimen in Women With Squamous Cervical Intraepithelial Neoplasia 3 (CIN 3) or Vulvar Intraepithelial Neoplasia 3 (VIN 3) Recruiting NCT03267680 Phase 2 Cyclophosphamide;Indomethacin;Omeprazole
14 A Phase I/II Trial of T Cell Receptor Gene Therapy Targeting HPV-16 E7 With or Without PD-1 Blockade for HPV-Associated Cancers Recruiting NCT02858310 Phase 1, Phase 2 Aldesleukin;Fludarabine;Cyclophosphamide
15 A Phase 2, Randomized, Vehicle-controlled, Double-blind Study to Explore the Efficacy, Pharmacodynamics and Safety of Topical Ionic Contra-viral Therapy (ICVT) Comprised of Digoxin and Furosemide in HPV-induced Genital Lesions of Immunocompromised and Immunocompetent Patients Terminated NCT03334240 Phase 2 CLS003;Vehicle
16 A Phase I Proof-of-Concept Study of Artesunate Ointment for the Treatment of Patients With High-Grade Vulvar Intraepithelial Neoplasia (HSIL VIN 2/3) Recruiting NCT03792516 Phase 1 artesunate ointment 40%
17 Creating and Validating a Patient-reported Outcome Instrument to Assess Symptom Experience Related to Surgical Wounds in Women With Vulvar Neoplasms - A Mixed Methods Study Unknown status NCT01300663
18 Interest of the Confocal Microscope in the Diagnosis of Epidermoid Carcinoma of the Vulva and Their Precursors Unknown status NCT02735109
19 A Pilot Study to Assess the Efficacy & Safety of Topical SR-T100 Gel in the Treatment of Human Vulva Pre-cancerous Lesions (Vulvar Intraepithelial Neoplasia; VIN) & Cutaneous Condyloma(External Genital Warts; EGWs) Completed NCT01676792 Early Phase 1 SR-T100 gel with 2.3% of SM in Solanum undatum plant extract
20 A Double Blind Placebo Controlled Trial of Autologous Platelet Rich Plasma (PRP) Intradermal Injections for the Treatment of Vulvar Lichen Sclerosus Completed NCT03045172 Placebo
21 A Randomized Controlled Trial of Ultrasonic Aspiration Versus CO2 Laser Ablation for the Treatment of Vulvar Intraepithelial Neoplasia Recruiting NCT02875561
22 A Long-term Follow-up Registry-based Cohort Study of HPV Vaccine Efficacy Against Cervical Pre-cancerous Lesions and Cervical Cancers in a Cohort of Females Previously Enrolled From Finland in Study HPV-008, as Compared to a Non-intervention Population -Based Reference Cohort of Females From Finland Enrolling by invitation NCT01393470
23 Evaluation of the Role of Vibrational Spectroscopy in the Assessment of Vulval Disease Suspended NCT02223975

Search NIH Clinical Center for Vulvar Intraepithelial Neoplasia

Genetic Tests for Vulvar Intraepithelial Neoplasia

Anatomical Context for Vulvar Intraepithelial Neoplasia

MalaCards organs/tissues related to Vulvar Intraepithelial Neoplasia:

41
Skin, T Cells, Testes, Lymph Node, Endothelial, Lung, Breast

Publications for Vulvar Intraepithelial Neoplasia

Articles related to Vulvar Intraepithelial Neoplasia:

(show top 50) (show all 585)
# Title Authors PMID Year
1
Risk of cervical and vaginal dysplasia after surgery for vulvar intraepithelial neoplasia or cancer: A 6 year follow-up study. 38
31375270 2019
2
Photodynamic therapy for treatment of usual-type vulvar intraepithelial neoplasia: a case report and literature review. 38
31364444 2019
3
Human Papillomavirus-Independent Squamous Lesions of the Vulva. 38
31097103 2019
4
Differentiated Vulvar Intraepithelial Neoplasia: A Brief Review of Clinicopathologic Features. 38
30640512 2019
5
Clinical and molecular classification of vulvar squamous pre-cancers. 38
30737358 2019
6
The Human Papillomavirus Vaccine as a Treatment 1 for HPV-related Dysplastic and Neoplastic Conditions: A Literature Review. 38
31085272 2019
7
Atypical fibroxanthoma associated with differentiated-type vulvar intraepithelial neoplasia: Case report of an unusual entity. 38
31192988 2019
8
Nail Squamous Cell Carcinoma: A Hidden High-risk HPV Reservoir for Sexually Transmitted Infections. 38
30930083 2019
9
Sec62/Ki67 and p16/Ki67 dual-staining immunocytochemistry in vulvar cytology for the identification of vulvar intraepithelial neoplasia and vulvar cancer: a pilot study. 38
30607586 2019
10
Classic Vulvar Intraepithelial Neoplasia With Superimposed Lichen Simplex Chronicus: A Unique Variant Mimicking Differentiated Vulvar Intraepithelial Neoplasia. 38
29750709 2019
11
Superficially invasive stage IA vulvar squamous cell carcinoma-therapy and prognosis. 38
30622111 2019
12
Genital lichen sclerosus et atrophicus in females: An update. 38
31143853 2019
13
The Impact of Focality and Centricity on Vulvar Intraepithelial Neoplasia on Disease Progression in HIV+ Patients: A 10-Year Retrospective Study. 38
31256169 2019
14
PD-L1 and IDO expression in cervical and vulvar invasive and intraepithelial squamous neoplasias: implications for combination immunotherapy. 38
30067880 2019
15
Systemic adverse events in imiquimod use for cervical intraepithelial neoplasia - A case series. 38
30906696 2019
16
Differentiated vulvar intraepithelial neoplasia (dVIN): the most helpful histological features and the utility of cytokeratins 13 and 17. 38
30187167 2018
17
Impact of re-excision of residual adjacent vulvar intraepithelial neoplasia (VIN III) and histological tumour-free margin (hTFM) on survival in primary squamous cell carcinoma of vulva. 38
30187190 2018
18
Molecular heterogeneity in human papillomavirus-dependent and -independent vulvar carcinogenesis. 38
30030907 2018
19
Vulvar intraepithelial neoplasia treated with a combination of surgical excision and laser ablation during pregnancy. 38
30214782 2018
20
Human Papillomavirus Genotypes From Vaginal and Vulvar Intraepithelial Neoplasia in Females 15-26 Years of Age. 38
29995724 2018
21
Differential expression patterns of GATA3 in usual and differentiated types of vulvar intraepithelial neoplasia: potential diagnostic implications. 38
29434343 2018
22
Vulvar intraepithelial neoplasia and vulvar squamous cell carcinoma: differential dermoscopic features in a case series, and a progression model. 38
29315730 2018
23
Differentiated Vulvar Intraepithelial Neoplasia-like and Lichen Sclerosus-like Lesions in HPV-associated Squamous Cell Carcinomas of the Vulva. 38
29505429 2018
24
[Vulvar intraepithelial neoplasia]. 38
29761782 2018
25
Vulvar cancer: Two pathways with different localization and prognosis. 38
29555332 2018
26
Epidermodysplasia Verruciformis-like HPV Infection of the Vulva in Immunosuppressed Women. 38
28700430 2018
27
Is Vulvovaginal Lichen Planus Associated With Squamous Cell Carcinoma? 38
29470358 2018
28
Does Differentiated Squamous Intraepithelial Neoplasia Occur in the Cervix? 38
28877072 2018
29
The Role of Photodynamic Therapy in the Treatment of Vulvar Intraepithelial Neoplasia. 38
29393881 2018
30
Vulvar intraepithelial neoplasia: Risk factors for recurrence. 38
29126556 2018
31
Dermoscopic features of pigmented vulvar intraepithelial neoplasia. 38
28940726 2018
32
Accentuated p53 staining in usual type vulvar dysplasia-A potential diagnostic pitfall. 38
29254796 2018
33
HPV-independent Differentiated Vulvar Intraepithelial Neoplasia (dVIN) is Associated With an Aggressive Clinical Course. 38
28319571 2017
34
HPV-related vulvar diseases and perspectives of p16INK4a immunochemistry: a review of the literature. 38
28574130 2017
35
Final efficacy, immunogenicity, and safety analyses of a nine-valent human papillomavirus vaccine in women aged 16-26 years: a randomised, double-blind trial. 38
28886907 2017
36
Normalizers for microRNA quantification in plasma of patients with vulvar intraepithelial neoplasia lesions and vulvar carcinoma. 38
29299981 2017
37
Papillomavirus genotyping on formaldehyde fixed paraffin-embedded tissues in vulvar intraepithelial neoplasia. 38
28795241 2017
38
HPV16 E7 DNA tattooing: safety, immunogenicity, and clinical response in patients with HPV-positive vulvar intraepithelial neoplasia. 38
28451790 2017
39
Vulvar Neoplasms, Benign and Malignant. 38
28778635 2017
40
p16 Expression and Biological Behavior of Flat Vulvar Low-grade Squamous Intraepithelial Lesions (LSIL). 38
28719486 2017
41
Decreased NK cell activity after partial vulvectomy in pregnant patient with vulvar intraepithelial neoplasia 3 (VIN3). 38
28954490 2017
42
Prevalence and type distribution of human papillomavirus in squamous cell carcinoma and intraepithelial neoplasia of the vulva. 38
28577297 2017
43
Lichen sclerosus in women: a review. 38
28661705 2017
44
Long-Lasting Increased Risk of Human Papillomavirus-Related Carcinomas and Premalignancies After Cervical Intraepithelial Neoplasia Grade 3: A Population-Based Cohort Study. 38
28541790 2017
45
Urologic Dermatology: a Review. 38
28667573 2017
46
Role of Human Papillomavirus in Vulvar Cancer. 38
28590952 2017
47
The Prevalence of Lichen Sclerosus in Patients With Vulvar Squamous Cell Carcinoma. 38
27801760 2017
48
Yield of Cytology Surveillance After High-Grade Vulvar Intraepithelial Neoplasia or Cancer. 38
28644191 2017
49
Assessment of CK17 as a Marker for the Diagnosis of Differentiated Vulvar Intraepithelial Neoplasia. 38
27513074 2017
50
Vulvar and Anal Intraepithelial Neoplasia: Terminology, Diagnosis, and Ancillary Studies. 38
28398952 2017

Variations for Vulvar Intraepithelial Neoplasia

Expression for Vulvar Intraepithelial Neoplasia

Search GEO for disease gene expression data for Vulvar Intraepithelial Neoplasia.

Pathways for Vulvar Intraepithelial Neoplasia

Pathways related to Vulvar Intraepithelial Neoplasia according to GeneCards Suite gene sharing:

(show all 39)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.67 TP53 CTNNB1 CDKN2A BIRC5
2
Show member pathways
12.47 TP53 CTNNB1 CDH1
3
Show member pathways
12.44 TP53 CDKN2A CDH1
4
Show member pathways
12.4 TP53 CTNNB1 CDKN2A CDH1
5
Show member pathways
12.36 TP53 CDKN2A BIRC5
6
Show member pathways
12.36 TP53 CTNNB1 BIRC5
7
Show member pathways
12.3 TP53 CTNNB1 CDKN2A CDH1 BIRC5
8 12.12 TP53 CDKN2A CDH1
9 12.11 TP53 CTNNB1 CDKN2A
10 11.96 TP53 CTNNB1 CDH1 BIRC5
11 11.89 TP53 CTNNB1 CDH1
12 11.87 CTNNB1 CDH1 BIRC5
13 11.8 TP53 CTNNB1 CDKN2A
14 11.74 TP53 CTNNB1 CDKN2A CDH1 BIRC5
15 11.71 TP53 CTNNB1 CDKN2A
16 11.68 TP53 CTNNB1 CDKN2A
17
Show member pathways
11.55 TP53 CTNNB1 CDH1 BIRC5
18 11.54 CTNNB1 CDH1
19
Show member pathways
11.54 TP53 CDKN2A
20 11.52 CTNNB1 CDH1
21 11.47 TP53 CTNNB1 CDH1 BIRC5
22 11.46 TP53 CTNNB1 CDKN2A
23 11.44 TP53 CDKN2A BIRC5
24 11.41 TP53 CDKN2A CDH1
25 11.39 TP53 CDKN2A
26 11.37 TP53 CDKN2A
27 11.36 TP53 BIRC5
28 11.29 CTNNB1 CDH1
29 11.24 CTNNB1 CDH1
30 11.23 CTNNB1 CDH1
31 11.2 TP53 BIRC5
32 11.14 TP53 CTNNB1
33 11.14 CTNNB1 CDH1
34 11.12 TP53 CDKN2A
35 11.1 TP53 BIRC5
36 10.99 CTNNB1 CDH1
37
Show member pathways
10.91 TP53 CDKN2A
38 10.9 TP53 CDKN2A
39 10.61 CTNNB1 CDH1

GO Terms for Vulvar Intraepithelial Neoplasia

Cellular components related to Vulvar Intraepithelial Neoplasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lateral plasma membrane GO:0016328 9.26 CTNNB1 CDH1
2 catenin complex GO:0016342 9.16 CTNNB1 CDH1
3 apical junction complex GO:0043296 8.96 CTNNB1 CDH1
4 flotillin complex GO:0016600 8.62 CTNNB1 CDH1

Biological processes related to Vulvar Intraepithelial Neoplasia according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.65 TP53 CTNNB1 CDKN2A
2 positive regulation of gene expression GO:0010628 9.63 TP53 CTNNB1 CDKN2A
3 positive regulation of transcription, DNA-templated GO:0045893 9.62 TP53 CTNNB1 CDKN2A CDH1
4 positive regulation of apoptotic process GO:0043065 9.61 TP53 CTNNB1 CDKN2A
5 regulation of apoptotic process GO:0042981 9.54 TP53 CTNNB1 BIRC5
6 Ras protein signal transduction GO:0007265 9.49 TP53 CDKN2A
7 negative regulation of transcription, DNA-templated GO:0045892 9.46 TP53 CTNNB1 CDKN2A BIRC5
8 adherens junction organization GO:0034332 9.4 CTNNB1 CDH1
9 replicative senescence GO:0090399 9.26 TP53 CDKN2A
10 entry of bacterium into host cell GO:0035635 8.96 CTNNB1 CDH1
11 cellular response to indole-3-methanol GO:0071681 8.62 CTNNB1 CDH1

Molecular functions related to Vulvar Intraepithelial Neoplasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 9.5 TP53 CTNNB1 CDKN2A
2 enzyme binding GO:0019899 9.33 TP53 CTNNB1 BIRC5
3 RNA polymerase II transcription factor binding GO:0001085 9.26 TP53 CTNNB1
4 transcription factor binding GO:0008134 9.13 TP53 CTNNB1 CDKN2A
5 disordered domain specific binding GO:0097718 8.8 TP53 CTNNB1 CDKN2A

Sources for Vulvar Intraepithelial Neoplasia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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