MCID: VLV009
MIFTS: 26

Vulvar Leiomyoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Vulvar Leiomyoma

MalaCards integrated aliases for Vulvar Leiomyoma:

Name: Vulvar Leiomyoma 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:5142
NCIt 51 C40326
UMLS 74 C1520087

Summaries for Vulvar Leiomyoma

Disease Ontology : 12 A vulvar benign neoplasm that is located in smooth muscle cells.

MalaCards based summary : Vulvar Leiomyoma is related to leiomyoma and leiomyomatosis. An important gene associated with Vulvar Leiomyoma is PGR (Progesterone Receptor), and among its related pathways/superpathways are Cell cycle Role of SCF complex in cell cycle regulation and Signaling by ERBB4. Affiliated tissues include smooth muscle, ovary and cervix.

Related Diseases for Vulvar Leiomyoma

Diseases related to Vulvar Leiomyoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 91)
# Related Disease Score Top Affiliating Genes
1 leiomyoma 30.8 ESR1 PGR
2 leiomyomatosis 30.0 ESR1 PGR
3 endometrial stromal nodule 10.1 CALD1 PGR
4 myoma 10.1 ESR1 PGR
5 vestibular gland benign neoplasm 10.1 ESR1 PGR
6 bartholin's gland adenoma 10.1 ESR1 PGR
7 vulvar syringoma 10.1 ESR1 PGR
8 lung leiomyoma 10.1 ESR1 PGR
9 glassy cell carcinoma of the cervix 10.1 ESR1 PGR
10 breast myofibroblastoma 10.1 CALD1 ESR1
11 trigonitis 10.1 ESR1 PGR
12 predominantly cortical thymoma 10.1 ESR1 PGR
13 glomangiomyoma 10.1 CALD1 ESR1
14 breast medullary carcinoma 10.1 ESR1 PGR
15 breast scirrhous carcinoma 10.1 ESR1 PGR
16 bartholin's gland benign neoplasm 10.1 ESR1 PGR
17 oncocytic breast carcinoma 10.1 ESR1 PGR
18 progesterone-receptor positive breast cancer 10.1 ESR1 PGR
19 progesterone resistance 10.1 ESR1 PGR
20 endometrial squamous cell carcinoma 10.1 ESR1 PGR
21 cribriform carcinoma 10.1 ESR1 PGR
22 endometrial mucinous adenocarcinoma 10.1 ESR1 PGR
23 adenoid basal cell carcinoma 10.1 ESR1 PGR
24 apocrine adenocarcinoma 10.1 ESR1 PGR
25 gender identity disorder 10.1 ESR1 PGR
26 deep angioma 10.1 ESR1 PGR
27 muscle cancer 10.1 CALD1 PGR
28 synchronous bilateral breast carcinoma 10.1 ESR1 PGR
29 breast adenoid cystic carcinoma 10.1 ESR1 PGR
30 female reproductive endometrioid cancer 10.1 ESR1 PGR
31 cervical carcinosarcoma 10.1 ESR1 PGR
32 estrogen excess 10.1 ESR1 PGR
33 intramuscular hemangioma 10.1 ESR1 PGR
34 glycogen-rich clear cell breast carcinoma 10.1 ESR1 PGR
35 mammographic density 10.1 ESR1 PGR
36 cervical clear cell adenocarcinoma 10.1 ESR1 PGR
37 retinitis pigmentosa 47 10.1 ESR1 PGR
38 inflammatory breast carcinoma 10.1 ESR1 PGR
39 retinitis pigmentosa 20 10.0 ESR1 PGR
40 adenosarcoma 10.0 ESR1 PGR
41 luminal breast carcinoma 10.0 ESR1 PGR
42 endometriosis of ovary 10.0 ESR1 PGR
43 endometriosis 10.0 ESR1 PGR
44 breast benign neoplasm 10.0 ESR1 PGR
45 thoracic benign neoplasm 10.0 ESR1 PGR
46 uterine corpus cancer 10.0 ESR1 PGR
47 lipid-rich carcinoma 10.0 ESR1 PGR
48 smooth muscle tumor 10.0 ESR1 PGR
49 uterine benign neoplasm 10.0 ESR1 PGR
50 endometritis 10.0 ESR1 PGR

Graphical network of the top 20 diseases related to Vulvar Leiomyoma:



Diseases related to Vulvar Leiomyoma

Symptoms & Phenotypes for Vulvar Leiomyoma

Drugs & Therapeutics for Vulvar Leiomyoma

Search Clinical Trials , NIH Clinical Center for Vulvar Leiomyoma

Genetic Tests for Vulvar Leiomyoma

Anatomical Context for Vulvar Leiomyoma

MalaCards organs/tissues related to Vulvar Leiomyoma:

42
Smooth Muscle, Ovary, Cervix

The Foundational Model of Anatomy Ontology organs/tissues related to Vulvar Leiomyoma:

20
Smooth Muscle Cells

Publications for Vulvar Leiomyoma

Articles related to Vulvar Leiomyoma:

# Title Authors Year
1
Review of the pathophysiology, diagnosis, and therapy of vulvar leiomyoma, a rare gynecological tumor. ( 28875758 )
2018
2
Differential Diagnosis between Bartholin Cyst and Vulvar Leiomyoma: Case Report. ( 28783860 )
2017
3
An unusual location of a vulvar leiomyoma. ( 25029096 )
2015
4
Androgen insensitivity syndrome with gynandroblastoma and vulvar leiomyoma: case report and literature review. ( 23552209 )
2013
5
Vulvar leiomyoma in association with gastrointestinal leiomyoma. ( 21806593 )
2011
6
Pleomorphic vulvar leiomyoma with local invasive behavior. ( 12528283 )
2002
7
Esophageal leiomyomatosis in a woman with a history of vulvar leiomyoma and Barrett's esophagus: a case report and review of the literature. ( 10867474 )
2000
8
Vulvar leiomyoma associated with estrogen/progestin therapy. A case report. ( 7738927 )
1995
9
Vulvar leiomyoma. ( 8385861 )
1993

Variations for Vulvar Leiomyoma

Expression for Vulvar Leiomyoma

Search GEO for disease gene expression data for Vulvar Leiomyoma.

Pathways for Vulvar Leiomyoma

Pathways related to Vulvar Leiomyoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.4 ESR1 PGR
2
Show member pathways
10.99 ESR1 PGR
3
Show member pathways
10.58 ESR1 PGR

GO Terms for Vulvar Leiomyoma

Biological processes related to Vulvar Leiomyoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription initiation from RNA polymerase II promoter GO:0006367 9.26 ESR1 PGR
2 steroid hormone mediated signaling pathway GO:0043401 9.16 ESR1 PGR
3 negative regulation of gene expression GO:0010629 9.13 ESR1 PGR PLAG1
4 transcription, DNA-templated GO:0006351 8.62 ESR1 PLAG1

Molecular functions related to Vulvar Leiomyoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity GO:0003700 9.54 ESR1 PGR PLAG1
2 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.43 ESR1 PGR PLAG1
3 ATPase binding GO:0051117 9.32 ESR1 PGR
4 steroid hormone receptor activity GO:0003707 9.16 ESR1 PGR
5 nuclear receptor activity GO:0004879 8.96 ESR1 PGR
6 steroid binding GO:0005496 8.62 ESR1 PGR

Sources for Vulvar Leiomyoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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