MCID: VLV009
MIFTS: 25

Vulvar Leiomyoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Vulvar Leiomyoma

MalaCards integrated aliases for Vulvar Leiomyoma:

Name: Vulvar Leiomyoma 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:5142
NCIt 49 C40326
UMLS 71 C1520087

Summaries for Vulvar Leiomyoma

Disease Ontology : 12 A vulvar benign neoplasm that is located in smooth muscle cells.

MalaCards based summary : Vulvar Leiomyoma is related to bizarre leiomyoma and leiomyoma. An important gene associated with Vulvar Leiomyoma is PLAG1 (PLAG1 Zinc Finger), and among its related pathways/superpathways are Cell adhesion molecules (CAMs) and Hematopoietic Stem Cells and Lineage-specific Markers. Affiliated tissues include smooth muscle cells, smooth muscle and uterus.

Related Diseases for Vulvar Leiomyoma

Diseases related to Vulvar Leiomyoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 253)
# Related Disease Score Top Affiliating Genes
1 bizarre leiomyoma 29.8 PGR ESR1 CLEC2A CALD1
2 leiomyoma 29.8 PGR MME HMGA2 ESR1 CD34
3 intravenous leiomyomatosis 28.6 PGR MME HMGA2 ESR1 CD34 CALD1
4 smooth muscle tumor 28.6 PGR MME HMGA2 ESR1 CD34 CALD1
5 bartholin's duct cyst 10.5 OCM CALD1
6 cutaneous leiomyosarcoma 10.4 CLEC2A CALD1
7 salivary gland adenoma, pleomorphic 10.4 PLAG1 HMGA2
8 pleomorphic adenoma carcinoma 10.4 PLAG1 HMGA2
9 fat necrosis of breast 10.4 HMGA2 ESR1
10 diffuse peritoneal leiomyomatosis 10.3 PGR CALD1
11 peritoneal benign neoplasm 10.3 PGR CALD1
12 glassy cell carcinoma of the cervix 10.3 PGR ESR1
13 bartholin's gland adenoid cystic carcinoma 10.3 PGR ESR1
14 mixed endometrial stromal and smooth muscle tumor 10.3 MME CALD1
15 vaginal endometrial stromal tumor 10.3 MME CALD1
16 fallopian tube leiomyoma 10.3 MME CALD1
17 chronic tympanitis 10.3 PGR ESR1
18 urethra leiomyoma 10.3 MME CALD1
19 bartholin's gland adenoma 10.3 PGR ESR1
20 granulomatous endometritis 10.3 PGR ESR1
21 fallopian tube benign neoplasm 10.3 MME CALD1
22 bartholin's gland benign neoplasm 10.3 PGR ESR1
23 vestibular gland benign neoplasm 10.3 PGR ESR1
24 vaginal glandular tumor 10.3 PGR ESR1
25 vulvar syringoma 10.3 PGR ESR1
26 trigonitis 10.3 PGR ESR1
27 breast scirrhous carcinoma 10.3 PGR ESR1
28 oncocytic breast carcinoma 10.3 PGR ESR1
29 subareolar duct papillomatosis 10.3 MME CALD1
30 cervical clear cell adenocarcinoma 10.3 PGR ESR1
31 clear cell hidradenoma 10.3 MME CLEC2A
32 nipple benign neoplasm 10.3 MME CALD1
33 hidradenoma 10.3 MME CLEC2A
34 ovarian seromucinous carcinoma 10.3 PGR ESR1
35 breast papillary carcinoma 10.3 PGR ESR1
36 comedo carcinoma 10.3 PGR ESR1
37 mammographic density 10.3 PGR ESR1
38 acanthoma 10.3 OCM CLEC2A
39 uterus perivascular epithelioid cell tumor 10.3 MME CALD1
40 endometrial stromal nodule 10.3 MME CALD1
41 lipid-rich carcinoma 10.3 PGR ESR1
42 cellular leiomyoma 10.3 MME CALD1
43 atypical polypoid adenomyoma 10.3 MME CALD1
44 glomangiomyoma 10.3 CD34 CALD1
45 deep leiomyoma 10.3 CD34 CALD1
46 nephrogenic adenofibroma 10.3 CD34 CALD1
47 syringoma 10.3 PLAG1 ESR1 CLEC2A
48 cervical adenomyoma 10.3 PGR MME
49 wolffian duct adenocarcinoma 10.3 MME ESR1
50 colon leiomyosarcoma 10.2 CD34 CALD1

Graphical network of the top 20 diseases related to Vulvar Leiomyoma:



Diseases related to Vulvar Leiomyoma

Symptoms & Phenotypes for Vulvar Leiomyoma

Drugs & Therapeutics for Vulvar Leiomyoma

Search Clinical Trials , NIH Clinical Center for Vulvar Leiomyoma

Genetic Tests for Vulvar Leiomyoma

Anatomical Context for Vulvar Leiomyoma

The Foundational Model of Anatomy Ontology organs/tissues related to Vulvar Leiomyoma:

19
Smooth Muscle Cells

MalaCards organs/tissues related to Vulvar Leiomyoma:

40
Smooth Muscle, Uterus

Publications for Vulvar Leiomyoma

Articles related to Vulvar Leiomyoma:

(show all 19)
# Title Authors PMID Year
1
[Metastatic leiomyoma or synchronous lesion of the uteri corpus and vulva?] 61
32096493 2020
2
Vulvar leiomyoma: a case report. 61
31312320 2019
3
Review of the pathophysiology, diagnosis, and therapy of vulvar leiomyoma, a rare gynecological tumor. 61
28875758 2018
4
Differential Diagnosis between Bartholin Cyst and Vulvar Leiomyoma: Case Report. 61
28783860 2017
5
Leiomyoma of the Vulva: A Diagnostic Challenge Case Report. 61
27818815 2016
6
An unusual location of a vulvar leiomyoma. 61
25029096 2015
7
Round ligament of uterus leiomyoma: an unusual cause of dyspareunia. 61
25834749 2015
8
Myxoid Epithelial Leiomyoma of the Vulva: A Case Report and Literature Review. 61
26185695 2015
9
Smooth muscle neoplasms of the vulva masquerading as Bartholin gland duct cysts. 61
24381397 2014
10
Androgen insensitivity syndrome with gynandroblastoma and vulvar leiomyoma: case report and literature review. 61
23552209 2013
11
Vulvar leiomyoma in association with gastrointestinal leiomyoma. 61
21806593 2011
12
[Vulvar leiomyoma. Report of a case]. 61
21966831 2011
13
A clonal translocation (7;8)(p13;q11.2) in a leiomyoma of the vulva. 61
16965956 2006
14
Pleomorphic vulvar leiomyoma with local invasive behavior. 61
12528283 2002
15
Esophageal leiomyomatosis in a woman with a history of vulvar leiomyoma and Barrett's esophagus: a case report and review of the literature. 61
10867474 2000
16
Vulvar leiomyoma associated with estrogen/progestin therapy. A case report. 61
7738927 1995
17
Myxoid leiomyoma of the vulva mimicking aggressive angiomyxoma. 61
8055112 1994
18
Vulvar leiomyoma. 61
8385861 1993
19
[Vulvar leiomyoma]. 61
5043627 1972

Variations for Vulvar Leiomyoma

Expression for Vulvar Leiomyoma

Search GEO for disease gene expression data for Vulvar Leiomyoma.

Pathways for Vulvar Leiomyoma

Pathways related to Vulvar Leiomyoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.5 PECAM1 NCAM1 CD34
2 11.2 NCAM1 MME CD34
3 10.67 NCAM1 MME CD34

GO Terms for Vulvar Leiomyoma

Cellular components related to Vulvar Leiomyoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.92 PECAM1 NCAM1 CLEC2A CD34

Biological processes related to Vulvar Leiomyoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.46 CD34 ESR1 PGR PLAG1
2 paracrine signaling GO:0038001 8.96 CD34 PGR
3 glomerular endothelium development GO:0072011 8.62 CD34 PECAM1

Molecular functions related to Vulvar Leiomyoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 8.92 PLAG1 PGR HMGA2 ESR1

Sources for Vulvar Leiomyoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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