MCID: VLV009
MIFTS: 26

Vulvar Leiomyoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Vulvar Leiomyoma

MalaCards integrated aliases for Vulvar Leiomyoma:

Name: Vulvar Leiomyoma 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:5142
NCIt 50 C40326
UMLS 70 C1520087

Summaries for Vulvar Leiomyoma

Disease Ontology : 12 A vulvar benign neoplasm that is located in smooth muscle cells.

MalaCards based summary : Vulvar Leiomyoma is related to bizarre leiomyoma and leiomyoma. An important gene associated with Vulvar Leiomyoma is PLAG1 (PLAG1 Zinc Finger), and among its related pathways/superpathways are Cell adhesion molecules and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include smooth muscle cells, smooth muscle and uterus.

Related Diseases for Vulvar Leiomyoma

Diseases related to Vulvar Leiomyoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 279)
# Related Disease Score Top Affiliating Genes
1 bizarre leiomyoma 30.0 PGR ESR1 CALD1
2 leiomyoma 30.0 PGR MME HMGA2 ESR1 CD34
3 intravenous leiomyomatosis 28.9 PGR MME HMGA2 ESR1 CD34 CALD1
4 smooth muscle tumor 28.9 PGR MME HMGA2 ESR1 CD34 CALD1
5 silver-russell syndrome due to a point mutation 10.3 PLAG1 HMGA2
6 salivary gland adenoma, pleomorphic 10.3 PLAG1 HMGA2
7 syringoma 10.3 PLAG1 ESR1
8 chondroid lipoma 10.3 PLAG1 HMGA2
9 pleomorphic adenoma carcinoma 10.3 PLAG1 HMGA2
10 diffuse peritoneal leiomyomatosis 10.3 PGR CALD1
11 vaginal endometrial stromal tumor 10.3 MME CALD1
12 mixed endometrial stromal and smooth muscle tumor 10.3 MME CALD1
13 fallopian tube leiomyoma 10.3 MME CALD1
14 urethra leiomyoma 10.3 MME CALD1
15 fallopian tube benign neoplasm 10.3 MME CALD1
16 subareolar duct papillomatosis 10.3 MME CALD1
17 nipple benign neoplasm 10.3 MME CALD1
18 glassy cell carcinoma of the cervix 10.3 PGR ESR1
19 breast intraductal papillomatosis 10.2 PGR ESR1
20 nipple carcinoma 10.2 PGR ESR1
21 bartholin's gland adenoma 10.2 PGR ESR1
22 bartholin's gland adenoid cystic carcinoma 10.2 PGR ESR1
23 bartholin's gland benign neoplasm 10.2 PGR ESR1
24 eccrine papillary adenoma 10.2 PLAG1 HMGA2
25 chronic tympanitis 10.2 PGR ESR1
26 vestibular gland benign neoplasm 10.2 PGR ESR1
27 granulomatous endometritis 10.2 PGR ESR1
28 vulvar syringoma 10.2 PGR ESR1
29 breast scirrhous carcinoma 10.2 PGR ESR1
30 oncocytic breast carcinoma 10.2 PGR ESR1
31 cervical clear cell adenocarcinoma 10.2 PGR ESR1
32 ovarian seromucinous carcinoma 10.2 PGR ESR1
33 uterus perivascular epithelioid cell tumor 10.2 MME CALD1
34 breast papillary carcinoma 10.2 PGR ESR1
35 vulvar sarcoma 10.2 PLAG1 CD34
36 endometrial stromal nodule 10.2 MME CALD1
37 uterus leiomyosarcoma 10.2 PGR CALD1
38 bartholin's duct cyst 10.2 PLAG1 OCM CALD1
39 comedo carcinoma 10.2 PGR ESR1
40 cellular leiomyoma 10.2 MME CALD1
41 atypical polypoid adenomyoma 10.2 MME CALD1
42 breast adenoid cystic carcinoma 10.2 PGR ESR1
43 glomangiomyoma 10.2 CD34 CALD1
44 intracranial meningioma 10.2 PGR ESR1
45 deep leiomyoma 10.2 CD34 CALD1
46 breast adenoma 10.2 PGR ESR1
47 breast leiomyosarcoma 10.2 CD34 CALD1
48 lipid-rich carcinoma 10.2 PGR ESR1
49 colon leiomyosarcoma 10.2 CD34 CALD1
50 cervical adenomyoma 10.2 PGR MME

Graphical network of the top 20 diseases related to Vulvar Leiomyoma:



Diseases related to Vulvar Leiomyoma

Symptoms & Phenotypes for Vulvar Leiomyoma

Drugs & Therapeutics for Vulvar Leiomyoma

Search Clinical Trials , NIH Clinical Center for Vulvar Leiomyoma

Genetic Tests for Vulvar Leiomyoma

Anatomical Context for Vulvar Leiomyoma

The Foundational Model of Anatomy Ontology organs/tissues related to Vulvar Leiomyoma:

19
Smooth Muscle Cells

MalaCards organs/tissues related to Vulvar Leiomyoma:

40
Smooth Muscle, Uterus

Publications for Vulvar Leiomyoma

Articles related to Vulvar Leiomyoma:

(show all 19)
# Title Authors PMID Year
1
[Metastatic leiomyoma or synchronous lesion of the uteri corpus and vulva?] 61
32096493 2020
2
Vulvar leiomyoma: a case report. 61
31312320 2019
3
Review of the pathophysiology, diagnosis, and therapy of vulvar leiomyoma, a rare gynecological tumor. 61
28875758 2018
4
Differential Diagnosis between Bartholin Cyst and Vulvar Leiomyoma: Case Report. 61
28783860 2017
5
Leiomyoma of the Vulva: A Diagnostic Challenge Case Report. 61
27818815 2016
6
An unusual location of a vulvar leiomyoma. 61
25029096 2015
7
Myxoid Epithelial Leiomyoma of the Vulva: A Case Report and Literature Review. 61
26185695 2015
8
Round ligament of uterus leiomyoma: an unusual cause of dyspareunia. 61
25834749 2015
9
Smooth muscle neoplasms of the vulva masquerading as Bartholin gland duct cysts. 61
24381397 2014
10
Androgen insensitivity syndrome with gynandroblastoma and vulvar leiomyoma: case report and literature review. 61
23552209 2013
11
Vulvar leiomyoma in association with gastrointestinal leiomyoma. 61
21806593 2011
12
[Vulvar leiomyoma. Report of a case]. 61
21966831 2011
13
A clonal translocation (7;8)(p13;q11.2) in a leiomyoma of the vulva. 61
16965956 2006
14
Pleomorphic vulvar leiomyoma with local invasive behavior. 61
12528283 2002
15
Esophageal leiomyomatosis in a woman with a history of vulvar leiomyoma and Barrett's esophagus: a case report and review of the literature. 61
10867474 2000
16
Vulvar leiomyoma associated with estrogen/progestin therapy. A case report. 61
7738927 1995
17
Myxoid leiomyoma of the vulva mimicking aggressive angiomyxoma. 61
8055112 1994
18
Vulvar leiomyoma. 61
8385861 1993
19
[Vulvar leiomyoma]. 61
5043627 1972

Variations for Vulvar Leiomyoma

Expression for Vulvar Leiomyoma

Search GEO for disease gene expression data for Vulvar Leiomyoma.

Pathways for Vulvar Leiomyoma

Pathways related to Vulvar Leiomyoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.51 PECAM1 NCAM1 CD34
2 11.2 NCAM1 MME CD34
3 10.67 NCAM1 MME CD34

GO Terms for Vulvar Leiomyoma

Biological processes related to Vulvar Leiomyoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.46 PLAG1 PGR ESR1 CD34
2 steroid hormone mediated signaling pathway GO:0043401 9.32 PGR ESR1
3 intracellular steroid hormone receptor signaling pathway GO:0030518 9.26 PGR ESR1
4 paracrine signaling GO:0038001 8.96 PGR CD34
5 glomerular endothelium development GO:0072011 8.62 PECAM1 CD34

Molecular functions related to Vulvar Leiomyoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid binding GO:0005496 8.96 PGR ESR1
2 steroid hormone receptor activity GO:0003707 8.62 PGR ESR1

Sources for Vulvar Leiomyoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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