MCID: VLV009
MIFTS: 26

Vulvar Leiomyoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Vulvar Leiomyoma

MalaCards integrated aliases for Vulvar Leiomyoma:

Name: Vulvar Leiomyoma 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5142
NCIt 50 C40326
UMLS 73 C1520087

Summaries for Vulvar Leiomyoma

Disease Ontology : 12 A vulvar benign neoplasm that is located in smooth muscle cells.

MalaCards based summary : Vulvar Leiomyoma is related to leiomyoma and leiomyomatosis. An important gene associated with Vulvar Leiomyoma is SLC4A1 (Solute Carrier Family 4 Member 1 (Diego Blood Group)), and among its related pathways/superpathways are Signaling by ERBB4 and Nuclear Receptor transcription pathway. Affiliated tissues include smooth muscle, lung and ovary.

Related Diseases for Vulvar Leiomyoma

Diseases related to Vulvar Leiomyoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 88)
# Related Disease Score Top Affiliating Genes
1 leiomyoma 30.7 ESR1 PGR
2 leiomyomatosis 30.0 ESR1 PGR
3 endometrial stromal nodule 10.1 CALD1 PGR
4 myoma 10.1 ESR1 PGR
5 vestibular gland benign neoplasm 10.1 ESR1 PGR
6 bartholin's gland adenoma 10.1 ESR1 PGR
7 vulvar syringoma 10.1 ESR1 PGR
8 glassy cell carcinoma of the cervix 10.1 ESR1 PGR
9 breast myofibroblastoma 10.1 CALD1 ESR1
10 lung leiomyoma 10.1 ESR1 PGR
11 trigonitis 10.0 PGR ESR1
12 glomangiomyoma 10.0 ESR1 CALD1
13 predominantly cortical thymoma 10.0 PGR ESR1
14 breast scirrhous carcinoma 10.0 PGR ESR1
15 breast medullary carcinoma 10.0 PGR ESR1
16 oncocytic breast carcinoma 10.0 PGR ESR1
17 bartholin's gland benign neoplasm 10.0 PGR ESR1
18 progesterone-receptor positive breast cancer 10.0 PGR ESR1
19 cribriform carcinoma 10.0 PGR ESR1
20 endometrial squamous cell carcinoma 10.0 PGR ESR1
21 progesterone resistance 10.0 PGR ESR1
22 apocrine adenocarcinoma 10.0 PGR ESR1
23 breast adenoid cystic carcinoma 10.0 PGR ESR1
24 adenoid basal cell carcinoma 10.0 PGR ESR1
25 endometrial mucinous adenocarcinoma 10.0 PGR ESR1
26 synchronous bilateral breast carcinoma 10.0 PGR ESR1
27 deep angioma 10.0 PGR ESR1
28 gender identity disorder 10.0 PGR ESR1
29 muscle cancer 10.0 CALD1 PGR
30 cervical carcinosarcoma 10.0 PGR ESR1
31 female reproductive endometrioid cancer 10.0 PGR ESR1
32 glycogen-rich clear cell breast carcinoma 10.0 ESR1 PGR
33 intramuscular hemangioma 10.0 PGR ESR1
34 estrogen excess 10.0 PGR ESR1
35 mammographic density 10.0 ESR1 PGR
36 cervical clear cell adenocarcinoma 10.0 ESR1 PGR
37 retinitis pigmentosa 47 10.0 ESR1 PGR
38 inflammatory breast carcinoma 10.0 ESR1 PGR
39 retinitis pigmentosa 20 10.0 ESR1 PGR
40 adenosarcoma 10.0 ESR1 PGR
41 luminal breast carcinoma 10.0 ESR1 PGR
42 endometriosis of ovary 10.0 ESR1 PGR
43 endometriosis 10.0 ESR1 PGR
44 breast benign neoplasm 10.0 ESR1 PGR
45 thoracic benign neoplasm 10.0 ESR1 PGR
46 uterine corpus cancer 10.0 ESR1 PGR
47 lipid-rich carcinoma 10.0 ESR1 PGR
48 smooth muscle tumor 10.0 ESR1 PGR
49 uterine benign neoplasm 10.0 ESR1 PGR
50 endometritis 10.0 ESR1 PGR

Graphical network of the top 20 diseases related to Vulvar Leiomyoma:



Diseases related to Vulvar Leiomyoma

Symptoms & Phenotypes for Vulvar Leiomyoma

Drugs & Therapeutics for Vulvar Leiomyoma

Search Clinical Trials , NIH Clinical Center for Vulvar Leiomyoma

Genetic Tests for Vulvar Leiomyoma

Anatomical Context for Vulvar Leiomyoma

MalaCards organs/tissues related to Vulvar Leiomyoma:

41
Smooth Muscle, Lung, Ovary, Prostate, Cervix

The Foundational Model of Anatomy Ontology organs/tissues related to Vulvar Leiomyoma:

19
Smooth Muscle Cells

Publications for Vulvar Leiomyoma

Articles related to Vulvar Leiomyoma:

# Title Authors Year
1
Review of the pathophysiology, diagnosis, and therapy of vulvar leiomyoma, a rare gynecological tumor. ( 28875758 )
2017
2
Differential Diagnosis between Bartholin Cyst and Vulvar Leiomyoma: Case Report. ( 28783860 )
2017
3
An unusual location of a vulvar leiomyoma. ( 25029096 )
2014
4
Androgen insensitivity syndrome with gynandroblastoma and vulvar leiomyoma: case report and literature review. ( 23552209 )
2013
5
Vulvar leiomyoma in association with gastrointestinal leiomyoma. ( 21806593 )
2011
6
Pleomorphic vulvar leiomyoma with local invasive behavior. ( 12528283 )
2002
7
Esophageal leiomyomatosis in a woman with a history of vulvar leiomyoma and Barrett's esophagus: a case report and review of the literature. ( 10867474 )
2000
8
Vulvar leiomyoma associated with estrogen/progestin therapy. A case report. ( 7738927 )
1995
9
Vulvar leiomyoma. ( 8385861 )
1993

Variations for Vulvar Leiomyoma

Expression for Vulvar Leiomyoma

Search GEO for disease gene expression data for Vulvar Leiomyoma.

Pathways for Vulvar Leiomyoma

Pathways related to Vulvar Leiomyoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.99 ESR1 PGR
2
Show member pathways
10.58 ESR1 PGR

GO Terms for Vulvar Leiomyoma

Biological processes related to Vulvar Leiomyoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid hormone mediated signaling pathway GO:0043401 9.16 ESR1 PGR
2 negative regulation of gene expression GO:0010629 9.13 ESR1 PGR PLAG1
3 transcription, DNA-templated GO:0006351 8.8 ESR1 PGR PLAG1

Molecular functions related to Vulvar Leiomyoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.5 ESR1 PGR PLAG1
2 ATPase binding GO:0051117 9.37 ESR1 PGR
3 steroid hormone receptor activity GO:0003707 9.26 ESR1 PGR
4 nuclear receptor activity GO:0004879 9.16 ESR1 PGR
5 proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001077 9.13 ESR1 PGR PLAG1
6 steroid binding GO:0005496 8.62 ESR1 PGR

Sources for Vulvar Leiomyoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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