MCID: VLV009
MIFTS: 27

Vulvar Leiomyoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Vulvar Leiomyoma

MalaCards integrated aliases for Vulvar Leiomyoma:

Name: Vulvar Leiomyoma 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:5142
NCIt 49 C40326
UMLS 71 C1520087

Summaries for Vulvar Leiomyoma

Disease Ontology : 12 A vulvar benign neoplasm that is located in smooth muscle cells.

MalaCards based summary : Vulvar Leiomyoma is related to intravenous leiomyomatosis and leiomyoma. An important gene associated with Vulvar Leiomyoma is PLAG1 (PLAG1 Zinc Finger), and among its related pathways/superpathways are Cell cycle Role of SCF complex in cell cycle regulation and Cell adhesion molecules (CAMs). Affiliated tissues include smooth muscle cells, breast and smooth muscle.

Related Diseases for Vulvar Leiomyoma

Diseases related to Vulvar Leiomyoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 262)
# Related Disease Score Top Affiliating Genes
1 intravenous leiomyomatosis 30.1 PGR ESR1 CALD1
2 leiomyoma 29.8 PGR HMGA2 ESR1 CD34
3 bizarre leiomyoma 29.8 PGR ESR1 CLEC2A CALD1
4 smooth muscle tumor 28.7 PGR HMGA2 ESR1 CD34 CALD1
5 acanthoma 10.4 OCM CLEC2A
6 peritoneal benign neoplasm 10.4 PGR CALD1
7 salivary gland adenoma, pleomorphic 10.4 PLAG1 HMGA2
8 myxoid leiomyosarcoma 10.4 PLAG1 PGR
9 eccrine papillary adenocarcinoma 10.4 PGR CLEC2A
10 cervical adenoma malignum 10.4 HMGA2 CALD1
11 chondroid lipoma 10.4 PLAG1 HMGA2
12 pleomorphic adenoma carcinoma 10.4 PLAG1 HMGA2
13 syringoma 10.3 ESR1 CLEC2A
14 apocrine sweat gland neoplasm 10.3 PGR CLEC2A
15 lung combined type small cell carcinoma 10.3 NCAM1 CALD1
16 glassy cell carcinoma of the cervix 10.3 PGR ESR1
17 bartholin's gland adenoid cystic carcinoma 10.3 PGR ESR1
18 chronic tympanitis 10.3 PGR ESR1
19 bartholin's gland adenoma 10.3 PGR ESR1
20 granulomatous endometritis 10.3 PGR ESR1
21 bartholin's gland benign neoplasm 10.3 PGR ESR1
22 vestibular gland benign neoplasm 10.3 PGR ESR1
23 breast juvenile papillomatosis 10.3 PGR ESR1
24 vulvar syringoma 10.3 PGR ESR1
25 trigonitis 10.3 PGR ESR1
26 breast scirrhous carcinoma 10.3 PGR ESR1
27 oncocytic breast carcinoma 10.3 PGR ESR1
28 breast papillary carcinoma 10.3 PGR ESR1
29 comedo carcinoma 10.3 PGR ESR1
30 breast metaplastic carcinoma 10.3 PGR ESR1
31 mammographic density 10.3 PGR ESR1
32 lipid-rich carcinoma 10.2 PGR ESR1
33 endometrial squamous cell carcinoma 10.2 PGR CDKN2A
34 endometrial mucinous adenocarcinoma 10.2 PGR CDKN2A
35 endosalpingiosis 10.2 PGR ESR1
36 progesterone-receptor negative breast cancer 10.2 PGR ESR1
37 progesterone resistance 10.2 PGR ESR1
38 epithelial-myoepithelial carcinoma 10.2 PLAG1 HMGA2
39 apocrine adenocarcinoma 10.2 PGR ESR1
40 myoepithelial carcinoma 10.2 PLAG1 HMGA2
41 gender identity disorder 10.2 PGR ESR1
42 breast osteosarcoma 10.2 PGR ESR1
43 cribriform carcinoma 10.2 PGR ESR1
44 intraductal breast neoplasm 10.2 PGR ESR1
45 transitional meningioma 10.2 PGR NCAM1
46 bartholin's duct cyst 10.2 OCM HMGA2 CALD1
47 atrophic vulva 10.2 ESR1 CDKN2A
48 intracystic papillary adenoma 10.2 PGR ESR1
49 bladder benign neoplasm 10.2 CDKN2A CALD1
50 ovarian endometrial cancer 10.2 PGR ESR1

Graphical network of the top 20 diseases related to Vulvar Leiomyoma:



Diseases related to Vulvar Leiomyoma

Symptoms & Phenotypes for Vulvar Leiomyoma

Drugs & Therapeutics for Vulvar Leiomyoma

Search Clinical Trials , NIH Clinical Center for Vulvar Leiomyoma

Genetic Tests for Vulvar Leiomyoma

Anatomical Context for Vulvar Leiomyoma

The Foundational Model of Anatomy Ontology organs/tissues related to Vulvar Leiomyoma:

19
Smooth Muscle Cells

MalaCards organs/tissues related to Vulvar Leiomyoma:

40
Breast, Smooth Muscle, Heart, Skin, Ovary, Lung, Uterus

Publications for Vulvar Leiomyoma

Articles related to Vulvar Leiomyoma:

(show all 18)
# Title Authors PMID Year
1
Vulvar leiomyoma: a case report. 61
31312320 2019
2
Review of the pathophysiology, diagnosis, and therapy of vulvar leiomyoma, a rare gynecological tumor. 61
28875758 2018
3
Differential Diagnosis between Bartholin Cyst and Vulvar Leiomyoma: Case Report. 61
28783860 2017
4
Leiomyoma of the Vulva: A Diagnostic Challenge Case Report. 61
27818815 2016
5
An unusual location of a vulvar leiomyoma. 61
25029096 2015
6
Round ligament of uterus leiomyoma: an unusual cause of dyspareunia. 61
25834749 2015
7
Myxoid Epithelial Leiomyoma of the Vulva: A Case Report and Literature Review. 61
26185695 2015
8
Smooth muscle neoplasms of the vulva masquerading as Bartholin gland duct cysts. 61
24381397 2014
9
Androgen insensitivity syndrome with gynandroblastoma and vulvar leiomyoma: case report and literature review. 61
23552209 2013
10
Vulvar leiomyoma in association with gastrointestinal leiomyoma. 61
21806593 2011
11
[Vulvar leiomyoma. Report of a case]. 61
21966831 2011
12
A clonal translocation (7;8)(p13;q11.2) in a leiomyoma of the vulva. 61
16965956 2006
13
Pleomorphic vulvar leiomyoma with local invasive behavior. 61
12528283 2002
14
Esophageal leiomyomatosis in a woman with a history of vulvar leiomyoma and Barrett's esophagus: a case report and review of the literature. 61
10867474 2000
15
Vulvar leiomyoma associated with estrogen/progestin therapy. A case report. 61
7738927 1995
16
Myxoid leiomyoma of the vulva mimicking aggressive angiomyxoma. 61
8055112 1994
17
Vulvar leiomyoma. 61
8385861 1993
18
[Vulvar leiomyoma]. 61
5043627 1972

Variations for Vulvar Leiomyoma

Expression for Vulvar Leiomyoma

Search GEO for disease gene expression data for Vulvar Leiomyoma.

Pathways for Vulvar Leiomyoma

Pathways related to Vulvar Leiomyoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.38 PGR ESR1 CDKN2A
2 10.97 PECAM1 NCAM1 CD34

GO Terms for Vulvar Leiomyoma

Cellular components related to Vulvar Leiomyoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 senescence-associated heterochromatin focus GO:0035985 8.62 HMGA2 CDKN2A

Biological processes related to Vulvar Leiomyoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.67 PLAG1 HMGA2 CDKN2A CD34
2 negative regulation of gene expression GO:0010629 9.56 PLAG1 PGR ESR1 CD34
3 positive regulation of cellular senescence GO:2000774 9.32 HMGA2 CDKN2A
4 paracrine signaling GO:0038001 9.16 PGR CD34
5 glomerular endothelium development GO:0072011 8.96 PECAM1 CD34
6 senescence-associated heterochromatin focus assembly GO:0035986 8.62 HMGA2 CDKN2A

Molecular functions related to Vulvar Leiomyoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.46 PLAG1 PGR HMGA2 ESR1
2 steroid binding GO:0005496 9.26 PGR ESR1
3 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 9.26 PLAG1 PGR HMGA2 ESR1
4 transcription factor binding GO:0008134 8.92 HMGA2 ESR1 CDKN2A CD34

Sources for Vulvar Leiomyoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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