MCID: VLV026
MIFTS: 23

Vulvar Leiomyosarcoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Vulvar Leiomyosarcoma

MalaCards integrated aliases for Vulvar Leiomyosarcoma:

Name: Vulvar Leiomyosarcoma 12 15 17 74

Classifications:



External Ids:

Disease Ontology 12 DOID:5286
NCIt 51 C40318
UMLS 74 C2168304

Summaries for Vulvar Leiomyosarcoma

Disease Ontology : 12 A vulvar sarcoma that has_material_basis in smooth muscle cells.

MalaCards based summary : Vulvar Leiomyosarcoma is related to leiomyosarcoma and motor neuron disease. An important gene associated with Vulvar Leiomyosarcoma is GPX1 (Glutathione Peroxidase 1), and among its related pathways/superpathways are Cellular Senescence (REACTOME) and DNA damage_Role of Brca1 and Brca2 in DNA repair. Affiliated tissues include smooth muscle and spinal cord, and related phenotypes are cellular and growth/size/body region

Related Diseases for Vulvar Leiomyosarcoma

Diseases related to Vulvar Leiomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 leiomyosarcoma 10.4
2 motor neuron disease 9.5 AR SOD2
3 vulvar sarcoma 9.0 AR GPX1 H2AFX PTPRC

Symptoms & Phenotypes for Vulvar Leiomyosarcoma

MGI Mouse Phenotypes related to Vulvar Leiomyosarcoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.85 AR GPX1 H2AFX PTPRC SOD2
2 growth/size/body region MP:0005378 9.8 AR GPX1 H2AFX PTPRC SOD2
3 hematopoietic system MP:0005397 9.77 AR GPX1 H2AFX PTPRC SOD2
4 endocrine/exocrine gland MP:0005379 9.73 AR GPX1 H2AFX PTPRC
5 homeostasis/metabolism MP:0005376 9.72 AR GPX1 H2AFX PTPRC SOD2
6 immune system MP:0005387 9.65 AR GPX1 H2AFX PTPRC SOD2
7 mortality/aging MP:0010768 9.55 AR GPX1 H2AFX PTPRC SOD2
8 neoplasm MP:0002006 9.26 AR H2AFX PTPRC SOD2
9 reproductive system MP:0005389 8.92 AR GPX1 H2AFX SOD2

Drugs & Therapeutics for Vulvar Leiomyosarcoma

Search Clinical Trials , NIH Clinical Center for Vulvar Leiomyosarcoma

Genetic Tests for Vulvar Leiomyosarcoma

Anatomical Context for Vulvar Leiomyosarcoma

MalaCards organs/tissues related to Vulvar Leiomyosarcoma:

42
Smooth Muscle, Spinal Cord

Publications for Vulvar Leiomyosarcoma

Articles related to Vulvar Leiomyosarcoma:

# Title Authors Year
1
MMPs and angiogenesis affect the metastatic potential of a human vulvar leiomyosarcoma cell line. ( 26010680 )
2015
2
Vulvar leiomyosarcoma in Bartholin's gland area: a case report and literature review. ( 18437406 )
2009
3
Vulvar leiomyosarcoma in a cat. ( 17601762 )
2007
4
Vulvar leiomyosarcoma: a case report in a Nigerian woman. ( 12384866 )
2002
5
Vulvar leiomyosarcoma in pregnancy. ( 2301486 )
1990
6
Vulvar leiomyosarcoma metastatic to the spinal cord in a dog. ( 632198 )
1978

Variations for Vulvar Leiomyosarcoma

Expression for Vulvar Leiomyosarcoma

Search GEO for disease gene expression data for Vulvar Leiomyosarcoma.

Pathways for Vulvar Leiomyosarcoma

GO Terms for Vulvar Leiomyosarcoma

Biological processes related to Vulvar Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of MAPK cascade GO:0043410 9.26 AR PTPRC
2 cellular response to oxidative stress GO:0034599 9.16 GPX1 SOD2
3 response to gamma radiation GO:0010332 8.96 GPX1 PTPRC
4 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902176 8.62 GPX1 SOD2

Sources for Vulvar Leiomyosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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