MCID: VLV020
MIFTS: 40

Vulvar Melanoma

Categories: Cancer diseases, Reproductive diseases, Skin diseases

Aliases & Classifications for Vulvar Melanoma

MalaCards integrated aliases for Vulvar Melanoma:

Name: Vulvar Melanoma 12 15
Malignant Melanoma of Vulva 12 74

Classifications:



External Ids:

Disease Ontology 12 DOID:2093
NCIt 51 C40329
UMLS 74 C0241989

Summaries for Vulvar Melanoma

Disease Ontology : 12 A vulva cancer that has_material_basis in melanocytes.

MalaCards based summary : Vulvar Melanoma, also known as malignant melanoma of vulva, is related to neurofibromatosis, type iv, of riccardi and melanoma, and has symptoms including pruritus and dysuria. An important gene associated with Vulvar Melanoma is KIT (KIT Proto-Oncogene, Receptor Tyrosine Kinase), and among its related pathways/superpathways are MAPK signaling pathway and Gastric cancer. Affiliated tissues include skin, thyroid and myeloid, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Vulvar Melanoma

Diseases related to Vulvar Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Related Disease Score Top Affiliating Genes
1 neurofibromatosis, type iv, of riccardi 30.0 HRAS KIT NF1
2 melanoma 10.7
3 thymoma, familial 10.4 HRAS KIT
4 giant congenital nevus 10.4 HRAS NRAS
5 conventional fibrosarcoma 10.3 KIT NRAS
6 benign struma ovarii 10.3 HRAS NRAS
7 schimmelpenning-feuerstein-mims syndrome 10.3 HRAS NRAS
8 aggressive digital papillary adenocarcinoma 10.3 HRAS KIT
9 malignant conjunctival melanoma 10.3 HRAS NRAS
10 melanomatosis 10.3 HRAS NRAS
11 lung adenoid cystic carcinoma 10.3 HRAS KIT
12 marcus gunn phenomenon 10.3 HRAS NRAS
13 malignant struma ovarii 10.2 HRAS NRAS
14 plexiform schwannoma 10.2 KIT NF1
15 amelanotic melanoma 10.2 KIT TYR
16 fetal adenoma 10.2 HRAS NRAS
17 malignant anus melanoma 10.2 KIT MLANA
18 core binding factor acute myeloid leukemia 10.2 HRAS KIT NRAS
19 renal cell carcinoma, papillary, 1 10.2 HRAS KIT NRAS
20 nodular malignant melanoma 10.2 EXT2 HRAS NRAS
21 halo nevi 10.2 MLANA TYR
22 acral lentiginous melanoma 10.2 KIT NRAS TERT
23 lymphoepithelioma-like thymic carcinoma 10.2 CD274 KIT
24 pigmented basal cell carcinoma 10.2 MLANA TYR
25 meningeal melanomatosis 10.2 HRAS NRAS
26 melanocytic nevus syndrome, congenital 10.2 HRAS NRAS TYR
27 melanoacanthoma 10.2 MLANA TYR
28 acneiform dermatitis 10.1 EIF2AK3 HRAS NRAS
29 diffuse meningeal melanocytosis 10.1 MLANA TYR
30 spindle cell liposarcoma 10.1 KIT MLANA
31 epithelioid cell melanoma 10.1 MLANA TYR
32 lichen sclerosus 10.1
33 myelodysplastic myeloproliferative cancer 10.1 HRAS NF1 NRAS
34 meningeal melanocytoma 10.1 MLANA NRAS RREB1
35 breast angiosarcoma 10.1 KIT MLANA TYR
36 bladder urothelial carcinoma 10.1 HRAS KIT NRAS
37 bone marrow cancer 10.0 HRAS KIT NF1
38 differentiated thyroid carcinoma 10.0 CD274 HRAS NRAS
39 small cell sarcoma 10.0 MLANA NRAS
40 melanoma, uveal 10.0 MLANA NRAS TYR
41 undifferentiated pleomorphic sarcoma 10.0 KIT MLANA
42 gastrointestinal system disease 10.0 FOXP3 HRAS KIT
43 melanoma, cutaneous malignant 1 10.0 HRAS KIT NRAS TERT
44 congenital mesoblastic nephroma 10.0 KIT NRAS
45 respiratory system cancer 10.0 CD274 HRAS TERT
46 leukemia, acute myeloid 9.9 HRAS KIT NRAS TERT
47 ovarian melanoma 9.9 HRAS KIT MLANA NRAS
48 mucosal melanoma 9.9 KIT NF1 NRAS TERT
49 thymoma 9.9 CTLA4 HRAS KIT
50 anal canal adenocarcinoma 9.9 CD274 FOXP3 HRAS

Graphical network of the top 20 diseases related to Vulvar Melanoma:



Diseases related to Vulvar Melanoma

Symptoms & Phenotypes for Vulvar Melanoma

UMLS symptoms related to Vulvar Melanoma:


pruritus, dysuria

GenomeRNAi Phenotypes related to Vulvar Melanoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.6 HRAS
2 Decreased viability GR00221-A-1 9.6 EIF2AK3 HRAS KIT NF1 NRAS
3 Decreased viability GR00221-A-2 9.6 EIF2AK3 HRAS NF1
4 Decreased viability GR00221-A-3 9.6 HRAS NRAS
5 Decreased viability GR00221-A-4 9.6 EIF2AK3 NF1
6 Decreased viability GR00301-A 9.6 KIT
7 Decreased viability GR00402-S-2 9.6 EIF2AK3 HRAS KIT NF1 NRAS

MGI Mouse Phenotypes related to Vulvar Melanoma:

47 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.21 CD274 CTLA4 EIF2AK3 FOXP3 HRAS KIT
2 endocrine/exocrine gland MP:0005379 10.18 CTLA4 EIF2AK3 FOXP3 HRAS KIT NF1
3 immune system MP:0005387 10.15 CD274 CTLA4 EIF2AK3 FOXP3 KIT NF1
4 digestive/alimentary MP:0005381 10.14 CTLA4 EIF2AK3 FOXP3 HRAS KIT NF1
5 mortality/aging MP:0010768 10.14 CD274 CTLA4 EIF2AK3 EXT2 FOXP3 HRAS
6 integument MP:0010771 10.13 CD274 CTLA4 FOXP3 HRAS KIT MLANA
7 craniofacial MP:0005382 10.02 FOXP3 HRAS KIT NF1 NRAS TYR
8 limbs/digits/tail MP:0005371 9.93 EIF2AK3 FOXP3 KIT NF1 NRAS TYR
9 no phenotypic analysis MP:0003012 9.92 CD274 EIF2AK3 FOXP3 HRAS KIT MLANA
10 liver/biliary system MP:0005370 9.91 CTLA4 EIF2AK3 FOXP3 KIT NF1 NRAS
11 neoplasm MP:0002006 9.91 EIF2AK3 HRAS KIT NF1 NRAS TERT
12 normal MP:0002873 9.86 CTLA4 FOXP3 HRAS KIT NF1 NRAS
13 pigmentation MP:0001186 9.63 CTLA4 KIT MLANA NF1 NRAS TYR
14 respiratory system MP:0005388 9.43 CTLA4 FOXP3 HRAS KIT NF1 TERT
15 skeleton MP:0005390 9.32 CD274 CTLA4 EIF2AK3 EXT2 HRAS KIT

Drugs & Therapeutics for Vulvar Melanoma

Search Clinical Trials , NIH Clinical Center for Vulvar Melanoma

Genetic Tests for Vulvar Melanoma

Anatomical Context for Vulvar Melanoma

MalaCards organs/tissues related to Vulvar Melanoma:

42
Skin, Thyroid, Myeloid, Lymph Node, Placenta, Brain, Bone Marrow

Publications for Vulvar Melanoma

Articles related to Vulvar Melanoma:

(show top 50) (show all 55)
# Title Authors Year
1
Association of Vulvar Melanoma with Lichen Sclerosus. ( 30521058 )
2019
2
Ringlike pattern as a dermatoscopy sign for vulvar melanosis does not preclude synchronous existence of vulvar melanoma. ( 30897233 )
2019
3
Recurrent vulvar melanoma in a patient with neurofibromatosis and gastrointestinal stromal tumour. ( 30665926 )
2019
4
Boron neutron capture therapy for vulvar melanoma and genital extramammary Paget's disease with curative responses. ( 29914570 )
2018
5
Recurrent vulvar melanoma invading urethra. Clinical case and literature review. ( 29888188 )
2018
6
Vulvar Melanoma with Isolated Metastasis to the Extraocular Muscles: Case Report and Brief Literature Review. ( 29848740 )
2018
7
Satellitosis and CD117 immunohistochemical expression correlates with poor outcome in thick vulvar melanoma. ( 27377140 )
2017
8
Tumor Thickness and Mitotic Rate Robustly Predict Melanoma-Specific Survival in Patients with Primary Vulvar Melanoma: A Retrospective Review of 100 Cases. ( 27864417 )
2017
9
Vulvar melanoma: relevant aspects in therapeutic management. ( 29186258 )
2017
10
Enhanced skin toxicity with concurrent ipilimumab and radiation in vaginal/vulvar melanoma: a case report and literature review. ( 30363303 )
2017
11
Vulvar Melanoma Associated with Lichen Sclerosus in a Child: Case Report and Literature Review. ( 27040997 )
2016
12
Prognostic Factors of Recurrence and Survival in Vulvar Melanoma: Subgroup Analysis of the VULvar CANcer Study. ( 27465889 )
2016
13
Surgical pathology, management and outcome in the vulvar melanoma associated with abdominal mass - a case report. ( 28174807 )
2016
14
Vulvar melanoma presenting as postmenopausal bleeding: a case report. ( 29894082 )
2016
15
Vulvar melanoma: a 33 years single Italian center experience. ( 25236321 )
2015
16
Vulvar melanoma with urethral invasion and bladder metastases - a case report and review of the literature. ( 25861315 )
2015
17
Amelanotic vulvar melanoma: a case report. ( 25993407 )
2015
18
Malignant Melanoma of Vulva and Vagina: A Histomorphological Review and Mutation Analysis--A Single-Center Study. ( 26225944 )
2015
19
A clinicopathological review of 33 patients with vulvar melanoma identifies c-KIT as a prognostic marker. ( 24535703 )
2014
20
Recurrent vulvar melanoma in 35-year-old pregnant women. ( 23343703 )
2013
21
Vulvar melanoma and endometrial polyp following breast carcinoma: a case report. ( 23781599 )
2013
22
Vulvar melanoma: a missed opportunity for early intervention? ( 22421122 )
2012
23
Reflectance confocal microscopy for the diagnosis of vulvar melanoma and melanosis: preliminary results. ( 23127153 )
2012
24
Nodular vulvar melanoma: a rare tumor with worse prognosis. ( 24293889 )
2012
25
Sentinel node detection by lymphoscintigraphy and sentinel lymph node biopsy in vulvar melanoma. ( 20107788 )
2010
26
A rare case of vulvar melanoma in a young woman who frequently tanned in tanning parlors. ( 20231517 )
2010
27
Vulvar melanoma: report on eleven cases and review of the literature. ( 20512279 )
2010
28
Amelanotic vulvar melanoma with intratumor histological heterogeneity. ( 20536668 )
2010
29
Vulvar melanoma: a report of 10 cases and review of the literature. ( 18337649 )
2008
30
Amelanotic vulvar melanoma: case report and review of the literature. ( 18516330 )
2008
31
Management of vulvar melanoma and review of the literature. ( 17624092 )
2007
32
Vulvar melanoma: a multivariable analysis of 644 patients. ( 17666603 )
2007
33
Vulvar melanoma in a 10-year-old girl in association with lichen sclerosus. ( 16427997 )
2006
34
Vulvar melanoma: diffuse melanosis and metastasis to the placenta. ( 14726891 )
2004
35
Vulvar melanoma: a report of 20 cases and review of the literature. ( 15034504 )
2004
36
Primary vulvar melanoma with satellite metastasis: dermoscopic findings. ( 15057006 )
2004
37
Vulvar melanoma: review of diagnosis, staging, and therapy. ( 15874838 )
2004
38
Malignant vulvar melanoma: colposcopic evaluation and review of the literature. A case report. ( 14658594 )
2003
39
Vulvar melanoma: is there a role for sentinel lymph node biopsy? ( 11905414 )
2002
40
The value of tan lines: vulvar melanoma and ultraviolet rays. ( 11466488 )
2001
41
Vulvar melanoma: a retrospective analysis and literature review. ( 11733955 )
2001
42
Vulvar melanoma at the M. D. Anderson Cancer Center: 25 years later. ( 11737466 )
2001
43
Successful treatment of pelvic recurrent vulvar melanoma. ( 11102624 )
2000
44
A survey of hospital management practices for vulvar melanoma. ( 10359360 )
1999
45
Vulvar melanoma, biologically different from other cutaneous melanomas. ( 10636360 )
1999
46
Vulvar melanoma in childhood. ( 9080895 )
1997
47
Vulvar melanoma. ( 8723827 )
1996
48
Vulvar melanoma reconsidered. ( 8508398 )
1993
49
Management of vulvar melanoma. ( 1612500 )
1992
50
Current management of vulvar melanoma. ( 2145021 )
1990

Variations for Vulvar Melanoma

Expression for Vulvar Melanoma

Search GEO for disease gene expression data for Vulvar Melanoma.

Pathways for Vulvar Melanoma

Pathways related to Vulvar Melanoma according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1 12.56 HRAS KIT NF1 NRAS
2
Show member pathways
12.55 HRAS KIT NRAS TERT
3
Show member pathways
12.52 HRAS KIT NF1 NRAS
4 12.01 ATF1 HRAS NRAS TERT
5
Show member pathways
11.85 HRAS NF1 NRAS
6
Show member pathways
11.81 HRAS NF1 NRAS
7 11.79 EIF2AK3 HRAS NRAS
8
Show member pathways
11.76 ATF1 HRAS NRAS
9 11.71 HRAS NF1 NRAS
10 11.68 HRAS NF1 NRAS
11 11.54 CD274 CTLA4 FOXP3 KIT MLANA
12
Show member pathways
11.5 HRAS KIT NRAS
13 11.31 HRAS KIT NRAS
14 11.25 EIF2AK3 HRAS NRAS
15 11.06 ATF1 CTLA4 HRAS NRAS
16
Show member pathways
11.01 HRAS NRAS
17 10.93 HRAS NRAS
18 10.9 HRAS NRAS
19 10.85 HRAS NRAS
20 10.81 HRAS NF1 NRAS
21 10.55 HRAS NRAS

GO Terms for Vulvar Melanoma

Biological processes related to Vulvar Melanoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.8 EIF2AK3 FOXP3 HRAS KIT
2 MAPK cascade GO:0000165 9.56 HRAS KIT NF1 NRAS
3 positive regulation of DNA replication GO:0045740 9.52 ATF1 HRAS
4 response to cadmium ion GO:0046686 9.51 KIT TERT
5 regulation of long-term neuronal synaptic plasticity GO:0048169 9.48 HRAS NF1
6 regulation of regulatory T cell differentiation GO:0045589 9.46 CTLA4 FOXP3
7 negative regulation of immune response GO:0050777 9.43 CTLA4 FOXP3
8 negative regulation of interleukin-10 production GO:0032693 9.4 CD274 FOXP3
9 positive regulation of phospholipase C activity GO:0010863 9.37 HRAS KIT
10 negative regulation of T cell proliferation GO:0042130 9.33 CD274 CTLA4 FOXP3
11 negative regulation of activated T cell proliferation GO:0046007 9.32 CD274 FOXP3
12 pigmentation GO:0043473 9.13 KIT NF1 TYR
13 Ras protein signal transduction GO:0007265 8.92 HRAS NF1 NRAS RREB1

Molecular functions related to Vulvar Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.77 ATF1 CD274 CTLA4 EIF2AK3 EXT2 FOXP3
2 protein homodimerization activity GO:0042803 9.1 EIF2AK3 EXT2 FOXP3 KIT TERT TYR

Sources for Vulvar Melanoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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