MCID: VLV020
MIFTS: 37

Vulvar Melanoma

Categories: Cancer diseases, Reproductive diseases, Skin diseases

Aliases & Classifications for Vulvar Melanoma

MalaCards integrated aliases for Vulvar Melanoma:

Name: Vulvar Melanoma 12 15
Malignant Melanoma of Vulva 12 73

Classifications:



External Ids:

Disease Ontology 12 DOID:2093
NCIt 50 C40329
SNOMED-CT 68 254896002
UMLS 73 C0241989

Summaries for Vulvar Melanoma

MalaCards based summary : Vulvar Melanoma, also known as malignant melanoma of vulva, is related to diffuse meningeal melanocytosis and skin melanoma, and has symptoms including dysuria and pruritus. An important gene associated with Vulvar Melanoma is KIT (KIT Proto-Oncogene Receptor Tyrosine Kinase), and among its related pathways/superpathways are Aldosterone synthesis and secretion and MAPK signaling pathway. Affiliated tissues include lymph node and placenta, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Vulvar Melanoma

Diseases related to Vulvar Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Related Disease Score Top Affiliating Genes
1 diffuse meningeal melanocytosis 30.1 MLANA TYR
2 skin melanoma 27.8 HRAS KIT MLANA NRAS TERT TYR
3 thymoma, familial 10.7 HRAS KIT
4 giant congenital nevus 10.7 HRAS NRAS
5 benign struma ovarii 10.6 HRAS NRAS
6 conventional fibrosarcoma 10.6 KIT NRAS
7 schimmelpenning-feuerstein-mims syndrome 10.6 HRAS NRAS
8 aggressive digital papillary adenocarcinoma 10.6 HRAS KIT
9 malignant conjunctival melanoma 10.6 HRAS NRAS
10 melanomatosis 10.6 HRAS NRAS
11 melanoma 10.6
12 marcus gunn phenomenon 10.6 HRAS NRAS
13 amelanotic melanoma 10.5 KIT TYR
14 malignant struma ovarii 10.5 HRAS NRAS
15 lung adenoid cystic carcinoma 10.5 HRAS KIT
16 malignant anus melanoma 10.5 KIT MLANA
17 meningeal melanomatosis 10.4 HRAS NRAS
18 congenital mesoblastic nephroma 10.4 KIT NRAS
19 nevus, epidermal 10.4 HRAS NRAS
20 mixed cell type cancer 10.4 HRAS KIT
21 core binding factor acute myeloid leukemia 10.4 HRAS KIT NRAS
22 renal cell carcinoma, papillary, 1 10.4 HRAS KIT NRAS
23 halo nevi 10.4 MLANA TYR
24 spindle cell liposarcoma 10.3 KIT MLANA
25 melanotic neurilemmoma 10.3 MLANA TYR
26 pigmented basal cell carcinoma 10.3 MLANA TYR
27 undifferentiated pleomorphic sarcoma 10.3 KIT MLANA
28 melanoacanthoma 10.3 MLANA TYR
29 acral lentiginous melanoma 10.3 KIT NRAS TERT
30 plexiform schwannoma 10.3 KIT NF1
31 epithelioid cell melanoma 10.3 MLANA TYR
32 melanocytic nevus syndrome, congenital 10.3 HRAS NRAS TYR
33 acneiform dermatitis 10.2 EIF2AK3 HRAS NRAS
34 dowling-degos disease 1 10.2 KIT TYR
35 small cell sarcoma 10.2 MLANA NRAS
36 meningeal melanocytoma 10.2 MLANA NRAS RREB1
37 melanoma, cutaneous malignant 1 10.1 HRAS NRAS TERT
38 breast angiosarcoma 10.1 KIT MLANA TYR
39 neurofibromatosis, type iv, of riccardi 10.0 HRAS KIT NF1
40 melanoma, uveal 10.0 MLANA NRAS TYR
41 myelodysplastic myeloproliferative cancer 10.0 HRAS NF1 NRAS
42 bone marrow cancer 9.9 HRAS KIT NF1
43 lichen sclerosus 9.9
44 noonan syndrome 1 9.9 HRAS NF1 NRAS
45 sporadic pheochromocytoma 9.9 HRAS NF1
46 respiratory system cancer 9.9 CD274 HRAS TERT
47 peripartum cardiomyopathy 9.8 CD274 NRAS
48 leukemia, acute myeloid 9.8 HRAS KIT NRAS TERT
49 ovarian melanoma 9.8 HRAS KIT MLANA NRAS
50 urethritis 9.7

Graphical network of the top 20 diseases related to Vulvar Melanoma:



Diseases related to Vulvar Melanoma

Symptoms & Phenotypes for Vulvar Melanoma

UMLS symptoms related to Vulvar Melanoma:


dysuria, pruritus

GenomeRNAi Phenotypes related to Vulvar Melanoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.6 HRAS
2 Decreased viability GR00221-A-1 9.6 EIF2AK3 HRAS KIT NF1 NRAS
3 Decreased viability GR00221-A-2 9.6 EIF2AK3 HRAS NF1
4 Decreased viability GR00221-A-3 9.6 HRAS NRAS
5 Decreased viability GR00221-A-4 9.6 EIF2AK3 NF1
6 Decreased viability GR00301-A 9.6 KIT
7 Decreased viability GR00402-S-2 9.6 EIF2AK3 HRAS KIT NF1 NRAS

MGI Mouse Phenotypes related to Vulvar Melanoma:

46 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.14 NF1 TYR NRAS KIT FOXP3 CD274
2 homeostasis/metabolism MP:0005376 10.13 NRAS TERT NF1 TYR KIT FOXP3
3 endocrine/exocrine gland MP:0005379 10.1 TERT NF1 TYR NRAS FOXP3 HRAS
4 mortality/aging MP:0010768 10.07 TERT NF1 TYR NRAS KIT FOXP3
5 immune system MP:0005387 10.06 TERT NF1 TYR NRAS KIT FOXP3
6 digestive/alimentary MP:0005381 10.05 TERT NF1 NRAS FOXP3 HRAS EIF2AK3
7 integument MP:0010771 10.03 NF1 TYR NRAS FOXP3 MLANA CD274
8 craniofacial MP:0005382 10 NF1 TYR NRAS KIT FOXP3 HRAS
9 limbs/digits/tail MP:0005371 9.88 NF1 TYR NRAS KIT FOXP3 EIF2AK3
10 no phenotypic analysis MP:0003012 9.86 TYR NRAS FOXP3 MLANA CD274 HRAS
11 neoplasm MP:0002006 9.8 TERT NF1 TYR NRAS HRAS KIT
12 normal MP:0002873 9.7 TERT NF1 TYR NRAS KIT FOXP3
13 pigmentation MP:0001186 9.35 MLANA NF1 TYR NRAS KIT
14 skeleton MP:0005390 9.28 TERT NF1 TYR NRAS CD274 HRAS

Drugs & Therapeutics for Vulvar Melanoma

Search Clinical Trials , NIH Clinical Center for Vulvar Melanoma

Genetic Tests for Vulvar Melanoma

Anatomical Context for Vulvar Melanoma

MalaCards organs/tissues related to Vulvar Melanoma:

41
Lymph Node, Placenta

Publications for Vulvar Melanoma

Articles related to Vulvar Melanoma:

(show all 50)
# Title Authors Year
1
Recurrent vulvar melanoma invading urethra. Clinical case and literature review. ( 29888188 )
2018
2
Vulvar Melanoma with Isolated Metastasis to the Extraocular Muscles: Case Report and Brief Literature Review. ( 29848740 )
2018
3
Boron neutron capture therapy for vulvar melanoma and genital extramammary Paget's disease with curative responses. ( 29914570 )
2018
4
Vulvar melanoma: relevant aspects in therapeutic management. ( 29186258 )
2017
5
Vulvar Melanoma Associated with Lichen Sclerosus in a Child: Case Report and Literature Review. ( 27040997 )
2016
6
Surgical pathology, management and outcome in the vulvar melanoma associated with abdominal mass - a case report. ( 28174807 )
2016
7
Prognostic Factors of Recurrence and Survival in Vulvar Melanoma: Subgroup Analysis of the VULvar CANcer Study. ( 27465889 )
2016
8
Tumor thickness and mitotic rate robustly predict melanoma-specific survival in patients with primary vulvar melanoma: A retrospective review of 100 cases. ( 27864417 )
2016
9
Satellitosis and CD117 immunohistochemical expression correlates with poor outcome in thick vulvar melanoma. ( 27377140 )
2016
10
Vulvar melanoma presenting as postmenopausal bleeding: a case report. ( 29894082 )
2016
11
Vulvar melanoma with urethral invasion and bladder metastases - a case report and review of the literature. ( 25861315 )
2015
12
Amelanotic vulvar melanoma: a case report. ( 25993407 )
2015
13
Malignant Melanoma of Vulva and Vagina: A Histomorphological Review and Mutation Analysis--A Single-Center Study. ( 26225944 )
2015
14
Vulvar melanoma: a 33 years single Italian center experience. ( 25236321 )
2014
15
A clinicopathological review of 33 patients with vulvar melanoma identifies c-KIT as a prognostic marker. ( 24535703 )
2014
16
Vulvar melanoma and endometrial polyp following breast carcinoma: a case report. ( 23781599 )
2013
17
Recurrent vulvar melanoma in 35-year-old pregnant women. ( 23343703 )
2013
18
Vulvar melanoma: a missed opportunity for early intervention? ( 22421122 )
2012
19
Reflectance confocal microscopy for the diagnosis of vulvar melanoma and melanosis: preliminary results. ( 23127153 )
2012
20
Nodular vulvar melanoma: a rare tumor with worse prognosis. ( 24293889 )
2012
21
Amelanotic vulvar melanoma with intratumor histological heterogeneity. ( 20536668 )
2010
22
A rare case of vulvar melanoma in a young woman who frequently tanned in tanning parlors. ( 20231517 )
2010
23
Vulvar melanoma: report on eleven cases and review of the literature. ( 20512279 )
2010
24
Sentinel node detection by lymphoscintigraphy and sentinel lymph node biopsy in vulvar melanoma. ( 20107788 )
2010
25
Vulvar melanoma: a report of 10 cases and review of the literature. ( 18337649 )
2008
26
Amelanotic vulvar melanoma: case report and review of the literature. ( 18516330 )
2008
27
Management of vulvar melanoma and review of the literature. ( 17624092 )
2007
28
Vulvar melanoma: a multivariable analysis of 644 patients. ( 17666603 )
2007
29
Vulvar melanoma in a 10-year-old girl in association with lichen sclerosus. ( 16427997 )
2006
30
Primary vulvar melanoma with satellite metastasis: dermoscopic findings. ( 15057006 )
2004
31
Vulvar melanoma: a report of 20 cases and review of the literature. ( 15034504 )
2004
32
Vulvar melanoma: review of diagnosis, staging, and therapy. ( 15874838 )
2004
33
Vulvar melanoma: diffuse melanosis and metastasis to the placenta. ( 14726891 )
2004
34
Malignant vulvar melanoma: colposcopic evaluation and review of the literature. A case report. ( 14658594 )
2003
35
Vulvar melanoma: is there a role for sentinel lymph node biopsy? ( 11905414 )
2002
36
Vulvar melanoma at the M. D. Anderson Cancer Center: 25 years later. ( 11737466 )
2001
37
The value of tan lines: vulvar melanoma and ultraviolet rays. ( 11466488 )
2001
38
Vulvar melanoma: a retrospective analysis and literature review. ( 11733955 )
2001
39
Successful treatment of pelvic recurrent vulvar melanoma. ( 11102624 )
2000
40
Vulvar melanoma, biologically different from other cutaneous melanomas. ( 10636360 )
1999
41
A survey of hospital management practices for vulvar melanoma. ( 10359360 )
1999
42
Vulvar melanoma in childhood. ( 9080895 )
1997
43
Vulvar melanoma. ( 8723827 )
1996
44
Vulvar melanoma reconsidered. ( 8508398 )
1993
45
Management of vulvar melanoma. ( 1612500 )
1992
46
Current management of vulvar melanoma. ( 2145021 )
1990
47
Prognostic features of vulvar melanoma: a clinicopathologic analysis. ( 3721696 )
1986
48
The recovery pattern of patients with vulvar melanoma treated by combined surgery and radiation therapy. ( 7159003 )
1982
49
Vulvar melanoma: a microstaging study. ( 7095591 )
1982
50
Cutaneous and vulvar melanoma: an update. ( 737922 )
1978

Variations for Vulvar Melanoma

Expression for Vulvar Melanoma

Search GEO for disease gene expression data for Vulvar Melanoma.

Pathways for Vulvar Melanoma

Pathways related to Vulvar Melanoma according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.69 ATF1 HRAS KIT NRAS TYR
2 12.57 HRAS KIT NF1 NRAS
3
Show member pathways
12.56 HRAS KIT NRAS TERT
4
Show member pathways
12.51 HRAS KIT NF1 NRAS
5 12.18 CD274 FOXP3 KIT MLANA
6 11.96 ATF1 HRAS NRAS TERT
7
Show member pathways
11.86 HRAS NF1 NRAS
8 11.83 EIF2AK3 HRAS NRAS
9
Show member pathways
11.81 HRAS NF1 NRAS
10 11.79 EIF2AK3 HRAS NRAS
11
Show member pathways
11.76 ATF1 HRAS NRAS
12 11.71 HRAS NF1 NRAS
13 11.68 HRAS NF1 NRAS
14
Show member pathways
11.42 HRAS KIT NRAS
15 11.14 HRAS KIT NRAS
16 11.1 HRAS NRAS
17 11.09 HRAS NRAS
18
Show member pathways
11.07 HRAS NRAS
19
Show member pathways
11.02 HRAS NRAS
20 10.95 HRAS NRAS
21 10.94 EIF2AK3 HRAS NRAS
22 10.92 HRAS NRAS
23 10.86 HRAS NRAS
24 10.52 HRAS NRAS
25 10.48 HRAS NF1 NRAS

GO Terms for Vulvar Melanoma

Biological processes related to Vulvar Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.67 EIF2AK3 FOXP3 HRAS KIT
2 response to cadmium ion GO:0046686 9.46 KIT TERT
3 MAPK cascade GO:0000165 9.46 HRAS KIT NF1 NRAS
4 negative regulation of interferon-gamma production GO:0032689 9.43 CD274 FOXP3
5 regulation of long-term neuronal synaptic plasticity GO:0048169 9.4 HRAS NF1
6 negative regulation of interleukin-10 production GO:0032693 9.32 CD274 FOXP3
7 negative regulation of activated T cell proliferation GO:0046007 9.26 CD274 FOXP3
8 pigmentation GO:0043473 9.13 KIT NF1 TYR
9 Ras protein signal transduction GO:0007265 8.92 HRAS NF1 NRAS RREB1

Molecular functions related to Vulvar Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.1 EIF2AK3 EXT2 FOXP3 KIT TERT TYR

Sources for Vulvar Melanoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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